CN108440686A - A kind of extraction equipment of heparin sodium - Google Patents

A kind of extraction equipment of heparin sodium Download PDF

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Publication number
CN108440686A
CN108440686A CN201810675066.9A CN201810675066A CN108440686A CN 108440686 A CN108440686 A CN 108440686A CN 201810675066 A CN201810675066 A CN 201810675066A CN 108440686 A CN108440686 A CN 108440686A
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CN
China
Prior art keywords
box body
motor
pot body
magnet
hemisphere
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CN201810675066.9A
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Chinese (zh)
Inventor
蔡秀萍
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Jiangsu Food and Pharmaceutical Science College
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Jiangsu Food and Pharmaceutical Science College
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Priority to CN201810675066.9A priority Critical patent/CN108440686A/en
Publication of CN108440686A publication Critical patent/CN108440686A/en
Pending legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0003General processes for their isolation or fractionation, e.g. purification or extraction from biomass

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Sustainable Development (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Cookers (AREA)

Abstract

The invention discloses a kind of extraction equipments of heparin sodium, including pot body, first motor, second motor, first rotating shaft and blade, the axis activity of first motor is inserted in cylindrical cavity, it is connected with second spring between the axis and cylindrical cavity of first motor, the hinge of several annular arrays is connected on the cylinder of connecting shaft, box body is movably hinged on the outside of hinge, it is provided with gap between adjacent box body, the first spring is connected between adjacent box body, the inside front of box body opens up jagged, hemisphere is fixedly connected on the outside of box body, the second magnet is fixedly connected with below box body, the surface of box body offers several evenly distributed through-holes, the bottom of pot body is connected with the first magnet of several annular arrays, the baffle of several annular arrays is connected on the inner wall of pot body, baffle and hemisphere selective exposure.The present invention can improve the deficiencies in the prior art, have better resin adsorption effect.

Description

A kind of extraction equipment of heparin sodium
Technical field
The present invention relates to a kind of extraction element, especially a kind of extraction equipment of heparin sodium.
Background technology
Heparin is a kind of glutinous polysaccharide being widely present in mammalian tissues, is primarily present with mast cell, has Blood coagulation resisting function is widely used in the treatment of operation and cerebral thrombus, myocardial infarction etc..Heparin sodium is the sodium salt of heparin.Heparin sodium Paid attention to by countries in the world as natural anticoagulative substance.It is also one of main outlet drug in China.With the depth of research Enter, it has been found that heparin sodium not only plays the role of anti-freezing, antithrombus formation and adjusts blood fat, also has anti-inflammatory, antiallergy, disease-resistant The functions such as poison, anticancer.Currently, heparin sodium is mainly extracted from pig, small sheep intestines mucous membrane and ox lung, doze casing brine etc..Research Show that heparin sodium is the content highest in pig intestinal mucosa.202953971 U of Chinese utility model patent CN disclose a kind of liver The absorption pot of plain sodium extraction.The absorption pot of this structure includes motor, agitating shaft and stirring wing, when heparin sodium dissolves in brine After, liquid enters in absorption pot, added with resin in pot, is stirred, makes in resin adsorption brine to brine and resin Heparin sodium, to obtain heparin sodium, but the adsorption effect of this device is general, and resin utilization rate is relatively low, to limit Its scope of application.
Invention content
The technical problem to be solved in the present invention is to provide a kind of extraction equipments of heparin sodium, can solve the prior art not Foot has better resin adsorption effect.
In order to solve the above technical problems, the technical solution used in the present invention is as follows.
A kind of extraction equipment of heparin sodium, including cylindrical pot body, the bottom of the pot body is connected with first motor, pot It is connected with the second motor at the top of body, first rotating shaft is connected with below the second motor, blade is fixedly connected in first rotating shaft, Pot nside further includes connecting shaft, and cylindrical cavity is offered below connecting shaft, and the axis activity of first motor is inserted in cylindricality sky Intracavitary is connected with second spring between the axis and cylindrical cavity of first motor, several annulars are connected on the cylinder of connecting shaft The hinge of arrangement is movably hinged with box body on the outside of hinge, gap is provided between adjacent box body, is connected between adjacent box body It is connected to the first spring, the inside front of box body opens up jagged, and hemisphere, the lower section of box body are fixedly connected on the outside of box body It is fixedly connected with the second magnet, the surface of box body offers several evenly distributed through-holes, and the bottom of pot body is connected with several First magnet of a annular array, the baffle of several annular arrays is connected on the inner wall of pot body, and baffle is selected with hemisphere Property contact.
Preferably, offering lid at the top of the box body.
Preferably, if the tray interior is provided with dried layer partition board.
Preferably, being also associated with sealing ring between the axis of the first motor and the bottom surface of pot body.
A kind of extracting method of the extraction equipment of above-mentioned heparin sodium, includes the following steps, pot nside places dissolving heparin Resin is placed in the inside of the brine of sodium, box body, and the second motor is rotated by first rotating shaft band movable vane piece, makes the salt flow in pot body Dynamic, first motor drives each box body to rotate by connecting shaft, accelerates to the saline flow in pot body, box surface is opened If through-hole, make the heparin sodium in the resin adsorption brine of box body, on the hemisphere and internal wall pot body when box body rotates on the outside of it Baffle contact with each other, hemisphere generates deformation, when hemisphere and baffle contact, stops the normal rotation compression the of the box body One spring makes hemisphere generate deformation and by baffle, loses interference effect after the first spring generates deformation to a certain extent Box body resetted under the action of the first spring spring-return power, so that box body is vibrated repeatedly in the horizontal direction, the rotation of box body makes The first magnet on the second magnet and pot body of lower section is repeatedly close and separation, when close to when close side be homopolarity, second Magnet and the first magnet close to when one upward active force is generated to box body, the upward active force of each box body is mutually stacked Add, each box body and connecting shaft is made integrally to move up, repeatedly, realizes the up-down vibration of box body.
It is using advantageous effect caused by above-mentioned technical proposal:The pot body of the present invention, inside is for placing dissolving liver The inside of the brine of plain sodium, box body passes through first rotating shaft band movable vane piece and turns for placing resin, the second motor rotation of pot body top Dynamic, so as to drive the saline flow in pot body, first motor rotation drives connecting shaft rotation, and then each box body is driven also to turn It is dynamic, the saline flow in pot body is further speeded up, the through-hole of box surface opened up can enable the resin of box body adsorb brine In heparin sodium, further, when box body rotates, on the outside of hemisphere can be contacted with each other with the baffle on internal wall pot body, half Sphere is rubber material, can generate certain deformation, when hemisphere is contacted with baffle, can stop the normal rotation of the box body simultaneously The first spring is compressed, after the first spring generates deformation to a certain extent, hemisphere is made to generate deformation and by baffle, lose dry Relate to effect box body can under the action of the first spring spring-return power Rapid reset, reach what box body horizontal direction was vibrated repeatedly Effect, further, the first magnet of the base circle arrangement of pot body, quantity is consistent with the quantity of box body, the rotation meeting of box body Keep the first magnet on the second magnet and pot body of lower section repeatedly close and separation, the second magnet and the first magnet are symmetrically to put Set, when close to when close side be homopolarity, due to the characteristic of magnet homopolar-repulsion, the second magnet and the first magnet close to when meeting One upward active force is generated to box body, the upward active force of each box body is mutually superimposed, makes each box body and connecting shaft It can integrally move up, repeatedly, achieve the effect that box body up-down vibration, so shaking by horizontal direction and vertical mode Dynamic and brine flowing drives, and enables the resin fully activity of tray interior, to reach better adsorption effect.Box body The lid that opens up of top, convenient for being placed and taken out resin, the partition board of tray interior, for resin to be carried out subregion placement, energy It further prevents pitch deposition and promotes adsorption area, sealing ring ensures close between the axis and the bottom surface of pot body of first motor Feng Xing.
Description of the drawings
Fig. 1 is the structure chart of a specific implementation mode of the invention.
Fig. 2 is the overlooking structure figure of multiple box bodys in a specific implementation mode of the invention.
Fig. 3 is the structure chart of box body in a specific implementation mode of the invention.
Fig. 4 is the structure chart of partition board in a specific implementation mode of the invention.
Fig. 5 is the structure chart of the first magnet in a specific implementation mode of the invention.
In figure:1, first motor;2, the second motor;3, pot body;4, connecting shaft;5, hinge;6, box body;7, hemisphere;8、 Baffle;9, bristle;10, arc frame;11, lid;12, first rotating shaft;13, blade;14, holder;15, the first spring;16, Gap;17, hairbrush;18, notch;19, cylindrical cavity;20, second spring;21, the first magnet;22, the second magnet;23, through-hole; 24, partition board;25, sealing ring.
Specific implementation mode
The standardized element used in the present invention can commercially, and shaped piece is according to specification and attached drawing Record can carry out customized, and the specific connection type of each part is all made of bolt ripe in the prior art, rivet, weldering The conventional means such as connect, paste, this will not be detailed here.
Referring to Fig.1-5, a specific implementation mode of the invention includes cylindrical pot body 1, and the bottom of pot body 1 is connected with the The top of one motor 1, pot body 1 is connected with the second motor 2, and the lower section of the second motor 2 is connected with first rotating shaft 12, first rotating shaft 12 On be fixedly connected with blade 13, further include connecting shaft 4 inside pot body 1, the lower section of connecting shaft 4 offers cylindrical cavity 19, first The axis activity of motor 1 is inserted in cylindrical cavity 19, and second spring is connected between the axis and cylindrical cavity 19 of first motor 1 20, the hinge 5 of several annular arrays is connected on the cylinder of connecting shaft 4, the outside of hinge 5 is movably hinged with box body 6, adjacent Box body 6 between be provided with gap 16, the first spring 15 is connected between adjacent box body 6, the inside front of box body 6 offers The outside of notch 18, box body 6 is fixedly connected with hemisphere 7, and the lower section of box body 6 is fixedly connected with the second magnet 22, box body 6 Surface offers several evenly distributed through-holes 23, and the bottom of pot body 1 is connected with the first magnet 21 of several annular arrays, The baffle 8 of several annular arrays, baffle 8 and 7 selective exposure of hemisphere are connected on the inner wall of pot body 1.The pot of the present invention Body 1, brine of the inside for placing dissolving heparin sodium, the inside of box body 6 is for placing resin, 12 turns of the second motor in top of pot body It is dynamic, it is rotated with movable vane piece 13 by first rotating shaft 12, so as to drive the saline flow in pot body 1, the rotation of first motor 1 to drive Connecting shaft 4 rotates, and then each box body 6 is driven also to rotate, and further speeds up the saline flow in pot body 1,6 surface of box body is opened If through-hole 23, the resin of box body 6 can be enable to adsorb the heparin sodium in brine, further, box body 6 rotate when, outside Hemisphere 7 can be contacted with each other with the baffle 8 on 1 inner wall of pot body, hemisphere 7 be rubber material, certain deformation can be generated, when When hemisphere 7 is contacted with baffle 8, it can stop the normal rotation of the box body 6 and compress the first spring 15, when the first spring 15 generates After deformation to a certain extent, so that hemisphere 7 is generated deformation and by baffle 8, the box body 6 for losing interference effect can be in the first spring Rapid reset under the action of 15 spring-return power achievees the effect that 6 horizontal direction of box body is vibrated repeatedly, further, pot body 1 First magnet 21 of base circle arrangement, quantity is consistent with the quantity of box body 6, and the rotation of box body 6 can make the second magnet of lower section 22 and pot body 1 on the first magnet 21 is repeatedly close and separation, the second magnet 22 and the first magnet 21 are symmetrically placed, when close When close side be homopolarity, due to the characteristic of magnet homopolar-repulsion, the second magnet 22 and the first magnet 21 close to when can be to box Body 6 generates a upward active force, and the upward active force of each box body 6 is mutually superimposed, makes each box body 6 and connecting shaft 4 It can integrally move up, repeatedly, achieve the effect that 6 up-down vibration of box body, so pass through horizontal direction and vertical mode Vibration and the flowing of brine drive, and enable the resin fully activity inside box body 6, to reach better adsorption effect.Institute The top for stating box body 6 offers lid 11.The lid 11 that the top of box body 6 opens up, convenient for being placed and taken out resin, the box body If 6 are internally provided with dried layer partition board 24.Partition board 24 inside box body 6 can further be prevented for resin to be carried out subregion placement Only pitch deposition and adsorption area is promoted, sealing ring 25 is also associated between the axis and the bottom surface of pot body 3 of the first motor 1. Sealing ring 25 ensures the leakproofness between the axis and the bottom surface of pot body 3 of first motor 1.
In addition, in order to reach the better using effect of the present invention, multiple notches 18 of the inside of box body 6 constitute one and half Spherical cavity is connected with holder 14 in the first rotating shaft 12, and the both sides of holder 14 are connected separately with arc frame 10, arc frame 10 outside is connected with bristle 9, and bristle 9 and the inside of box body 6 contact with each other, several rings are also associated on the inner wall of pot body 1 The hairbrush 17 of shape arrangement, hairbrush 17 and the outer wall of box body 6 contact with each other, and by above structure, bristle 9 and hairbrush 17 can be to boxes The surface of body 6 carries out brush and sweeps, and prevents foreign matter from showing to accumulate in box body 6, blocks through-hole 23, and then ensure better adsorption effect.
Wherein, sufficient public affairs have been carried out in the resin etc. used in the present invention in the patent document that background technology is quoted It opens, belongs to the ripe prior art, this will not be detailed here its concrete structure.
In the description of the present invention, it is to be understood that, term " longitudinal direction ", " transverse direction ", "upper", "lower", "front", "rear", The orientation or positional relationship of the instructions such as "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outside" is based on attached drawing institute The orientation or positional relationship shown is merely for convenience of the description present invention, does not indicate or imply the indicated device or element must There must be specific orientation, with specific azimuth configuration and operation, therefore be not considered as limiting the invention.
The above shows and describes the basic principles and main features of the present invention and the advantages of the present invention.The technology of the industry Personnel are it should be appreciated that the present invention is not limited to the above embodiments, and the above embodiments and description only describe this The principle of invention, without departing from the spirit and scope of the present invention, various changes and improvements may be made to the invention, these changes Change and improvement all fall within the protetion scope of the claimed invention.The claimed scope of the invention by appended claims and its Equivalent thereof.

Claims (5)

1. a kind of extraction equipment of heparin sodium, including cylindrical pot body(1), it is characterised in that:The pot body(1)Bottom connect It is connected to first motor(1), pot body(1)Top be connected with the second motor(2), the second motor(2)Lower section be connected with first turn Axis(12), first rotating shaft(12)On be fixedly connected with blade(13), pot body(1)Inside further includes connecting shaft(4), connecting shaft(4) Lower section offer cylindrical cavity(19), first motor(1)Axis activity be inserted in cylindrical cavity(19)It is interior, first motor(1) Axis and cylindrical cavity(19)Between be connected with second spring(20), connecting shaft(4)Cylinder on be connected with several ring rows The hinge of row(5), hinge(5)Outside be movably hinged with box body(6), adjacent box body(6)Between be provided with gap(16), phase Adjacent box body(6)Between be connected with the first spring(15), box body(6)Inside front open up it is jagged(18), box body(6) Outside is fixedly connected with hemisphere(7), box body(6)Lower section be fixedly connected with the second magnet(22), box body(6)Surface open up There are several evenly distributed through-holes(23), pot body(1)Bottom be connected with the first magnet of several annular arrays(21), pot Body(1)Inner wall on be connected with the baffles of several annular arrays(8), baffle(8)With hemisphere(7)Selective exposure.
2. the extraction equipment of heparin sodium according to claim 1, it is characterised in that:The box body(6)Top offer Lid(11).
3. the extraction equipment of heparin sodium according to claim 1, it is characterised in that:The box body(6)If being internally provided with Dried layer partition board(24).
4. the extraction equipment of heparin sodium according to claim 1, it is characterised in that:The first motor(1)Axis and pot Body(3)Bottom surface between be also associated with sealing ring(25).
5. a kind of extracting method of the extraction equipment of the heparin sodium described in claim 1-4 any one, it is characterised in that including Following steps:Pot body(1)Place the brine of dissolving heparin sodium, box body in inside(6)Inside place resin, the second motor(2)It is logical Cross first rotating shaft(12)Band movable vane piece(13)Rotation, makes pot body(1)Interior saline flow, first motor(1)Pass through connecting shaft(4) Drive each box body(6)Rotation, to pot body(1)Interior saline flow is accelerated, box body(6)The through-hole opened up on surface (23), make box body(6)Resin adsorption brine in heparin sodium, box body(6)Hemisphere when rotation on the outside of it(7)With pot body (1)Baffle on inner wall(8)It contacts with each other, hemisphere generates deformation, works as hemisphere(7)With baffle(8)When contact, stop the box Body(6)Normal rotation compress the first spring(15), when the first spring(15)After generating deformation to a certain extent, make hemisphere (7)It generates deformation and passes through baffle(8), lose the box body of interference effect(6)In the first spring(15)The effect of spring-return power Lower reset, makes box body(6)It vibrates repeatedly in the horizontal direction, box body(6)Rotation make lower section the second magnet(22)And pot body(1) On the first magnet(21)Repeatedly close and separation, close side is homopolarity, the second magnet when close(22)With the first magnetic Iron(21)To box body when close(6)Generate a upward active force, each box body(6)Upward active force it is mutually superimposed, Make each box body(6)And connecting shaft(4)Entirety moves up, and repeatedly, realizes box body(6)Up-down vibration.
CN201810675066.9A 2018-06-27 2018-06-27 A kind of extraction equipment of heparin sodium Pending CN108440686A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810675066.9A CN108440686A (en) 2018-06-27 2018-06-27 A kind of extraction equipment of heparin sodium

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Application Number Priority Date Filing Date Title
CN201810675066.9A CN108440686A (en) 2018-06-27 2018-06-27 A kind of extraction equipment of heparin sodium

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CN108440686A true CN108440686A (en) 2018-08-24

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110639237A (en) * 2019-10-29 2020-01-03 江苏千牧生物科技股份有限公司 Raw material separation device for sodium heparin processing

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN202953971U (en) * 2012-08-30 2013-05-29 资阳市开良天然畜产有限公司 Adsorption pot for extracting heparin sodium
CN204058317U (en) * 2014-10-11 2014-12-31 重庆三腾食品有限公司 A kind of salt solution heparin sodium resin clean tank
CN206188698U (en) * 2016-10-25 2017-05-24 江苏久辉畜产品有限公司 Liquaemin processing is with resin adsorption and filtration system
CN206980616U (en) * 2017-05-15 2018-02-09 骆雪娥 A kind of oscillatory type Chinese medicine agitator tank
CN107777799A (en) * 2017-11-30 2018-03-09 薛春红 A kind of New foul water disposal facility

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN202953971U (en) * 2012-08-30 2013-05-29 资阳市开良天然畜产有限公司 Adsorption pot for extracting heparin sodium
CN204058317U (en) * 2014-10-11 2014-12-31 重庆三腾食品有限公司 A kind of salt solution heparin sodium resin clean tank
CN206188698U (en) * 2016-10-25 2017-05-24 江苏久辉畜产品有限公司 Liquaemin processing is with resin adsorption and filtration system
CN206980616U (en) * 2017-05-15 2018-02-09 骆雪娥 A kind of oscillatory type Chinese medicine agitator tank
CN107777799A (en) * 2017-11-30 2018-03-09 薛春红 A kind of New foul water disposal facility

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110639237A (en) * 2019-10-29 2020-01-03 江苏千牧生物科技股份有限公司 Raw material separation device for sodium heparin processing

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Application publication date: 20180824

RJ01 Rejection of invention patent application after publication