CN108434330A - A kind of nail covers and pharmaceutical composition for treating onychomycosis - Google Patents
A kind of nail covers and pharmaceutical composition for treating onychomycosis Download PDFInfo
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- CN108434330A CN108434330A CN201810597566.5A CN201810597566A CN108434330A CN 108434330 A CN108434330 A CN 108434330A CN 201810597566 A CN201810597566 A CN 201810597566A CN 108434330 A CN108434330 A CN 108434330A
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- Prior art keywords
- nail
- parts
- nail covers
- agent
- covers
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- 208000010195 Onychomycosis Diseases 0.000 title claims abstract description 39
- 201000005882 tinea unguium Diseases 0.000 title claims abstract description 39
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 16
- 239000003814 drug Substances 0.000 claims abstract description 53
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 34
- 229940079593 drug Drugs 0.000 claims abstract description 31
- 230000003139 buffering effect Effects 0.000 claims abstract description 13
- 241000723346 Cinnamomum camphora Species 0.000 claims abstract description 9
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims abstract description 8
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 claims abstract description 8
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 8
- 229930008380 camphor Natural products 0.000 claims abstract description 8
- 229960000846 camphor Drugs 0.000 claims abstract description 8
- 239000000470 constituent Substances 0.000 claims abstract description 8
- 229940041616 menthol Drugs 0.000 claims abstract description 8
- OCAPBUJLXMYKEJ-UHFFFAOYSA-N 1-[biphenyl-4-yl(phenyl)methyl]imidazole Chemical compound C1=NC=CN1C(C=1C=CC(=CC=1)C=1C=CC=CC=1)C1=CC=CC=C1 OCAPBUJLXMYKEJ-UHFFFAOYSA-N 0.000 claims abstract description 4
- 244000025254 Cannabis sativa Species 0.000 claims abstract description 4
- 229940037003 alum Drugs 0.000 claims abstract description 4
- 229960002206 bifonazole Drugs 0.000 claims abstract description 4
- CPKVUHPKYQGHMW-UHFFFAOYSA-N 1-ethenylpyrrolidin-2-one;molecular iodine Chemical compound II.C=CN1CCCC1=O CPKVUHPKYQGHMW-UHFFFAOYSA-N 0.000 claims description 12
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 claims description 12
- 229920000153 Povidone-iodine Polymers 0.000 claims description 12
- 229960001621 povidone-iodine Drugs 0.000 claims description 12
- 239000000463 material Substances 0.000 claims description 11
- 239000000843 powder Substances 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 7
- 229920001296 polysiloxane Polymers 0.000 claims description 7
- 230000008569 process Effects 0.000 claims description 7
- 239000011347 resin Substances 0.000 claims description 7
- 229920005989 resin Polymers 0.000 claims description 7
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 6
- 239000006071 cream Substances 0.000 claims description 6
- 239000003349 gelling agent Substances 0.000 claims description 6
- 238000009434 installation Methods 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 6
- 239000002390 adhesive tape Substances 0.000 claims description 5
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims description 3
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 claims description 3
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 3
- 239000005864 Sulphur Substances 0.000 claims description 3
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 claims description 3
- 229940116229 borneol Drugs 0.000 claims description 3
- 238000001816 cooling Methods 0.000 claims description 3
- 229910052802 copper Inorganic materials 0.000 claims description 3
- 239000010949 copper Substances 0.000 claims description 3
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 3
- 238000003958 fumigation Methods 0.000 claims description 3
- 238000002844 melting Methods 0.000 claims description 3
- 230000008018 melting Effects 0.000 claims description 3
- 235000015927 pasta Nutrition 0.000 claims description 3
- 238000012216 screening Methods 0.000 claims description 3
- 210000000582 semen Anatomy 0.000 claims description 3
- 239000011780 sodium chloride Substances 0.000 claims description 3
- 239000007779 soft material Substances 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 239000012780 transparent material Substances 0.000 claims description 3
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 claims 2
- IIUZTXTZRGLYTI-UHFFFAOYSA-N Dihydrogriseofulvin Natural products COC1CC(=O)CC(C)C11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 IIUZTXTZRGLYTI-UHFFFAOYSA-N 0.000 claims 1
- UXWOXTQWVMFRSE-UHFFFAOYSA-N Griseoviridin Natural products O=C1OC(C)CC=C(C(NCC=CC=CC(O)CC(O)C2)=O)SCC1NC(=O)C1=COC2=N1 UXWOXTQWVMFRSE-UHFFFAOYSA-N 0.000 claims 1
- DDUHZTYCFQRHIY-UHFFFAOYSA-N Negwer: 6874 Natural products COC1=CC(=O)CC(C)C11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 DDUHZTYCFQRHIY-UHFFFAOYSA-N 0.000 claims 1
- 239000003205 fragrance Substances 0.000 claims 1
- DDUHZTYCFQRHIY-RBHXEPJQSA-N griseofulvin Chemical compound COC1=CC(=O)C[C@@H](C)[C@@]11C(=O)C(C(OC)=CC(OC)=C2Cl)=C2O1 DDUHZTYCFQRHIY-RBHXEPJQSA-N 0.000 claims 1
- 229960002867 griseofulvin Drugs 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 28
- 230000000857 drug effect Effects 0.000 abstract description 4
- DOMXUEMWDBAQBQ-WEVVVXLNSA-N terbinafine Chemical compound C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 DOMXUEMWDBAQBQ-WEVVVXLNSA-N 0.000 abstract description 3
- 229960002722 terbinafine Drugs 0.000 abstract description 3
- 230000004888 barrier function Effects 0.000 abstract description 2
- 230000000903 blocking effect Effects 0.000 abstract description 2
- 210000000282 nail Anatomy 0.000 description 156
- 210000003371 toe Anatomy 0.000 description 24
- 238000000465 moulding Methods 0.000 description 9
- 230000001225 therapeutic effect Effects 0.000 description 9
- 241000209094 Oryza Species 0.000 description 7
- 235000007164 Oryza sativa Nutrition 0.000 description 7
- 235000009566 rice Nutrition 0.000 description 7
- 230000009471 action Effects 0.000 description 6
- 230000003796 beauty Effects 0.000 description 5
- 230000003902 lesion Effects 0.000 description 5
- 239000002674 ointment Substances 0.000 description 5
- 230000002045 lasting effect Effects 0.000 description 4
- VIKNJXKGJWUCNN-XGXHKTLJSA-N norethisterone Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 VIKNJXKGJWUCNN-XGXHKTLJSA-N 0.000 description 4
- 241000233866 Fungi Species 0.000 description 3
- 230000017531 blood circulation Effects 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 210000004905 finger nail Anatomy 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 206010061876 Obstruction Diseases 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 238000005452 bending Methods 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 238000007596 consolidation process Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000009966 trimming Methods 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 238000005336 cracking Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000036651 mood Effects 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
-
- A—HUMAN NECESSITIES
- A45—HAND OR TRAVELLING ARTICLES
- A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
- A45D31/00—Artificial nails
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
- A61K31/125—Camphor; Nuclear substituted derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
- A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
- A61K31/79—Polymers of vinyl pyrrolidone
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- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/68—Plantaginaceae (Plantain Family)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Emergency Medicine (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention belongs to pharmacy and its device fields, disclose a kind of pharmaceutical composition, including the A agent and B agent successively used, the constituent content of the A agent includes 13 parts of Terbinafine, 23 parts of bifonazole, 36 parts of sealwort, the constituent content of B agent includes 13 parts of car fare grass, 2 3.5 parts of alum；A kind of nail covers, including nail covers ontology, the arc-shaped laminated structure of width direction of the nail covers are also disclosed, length direction both sides of the edge are provided with to curve inwardly and be hooked for accommodating the slot of nail；The nail covers inner surface is bonded with the buffering medicine pad for the treatment of onychomycosis；Pharmaceutical composition of the present invention can be more quickly by drug effect skin permeation and nail cover cuticula by adding menthol and camphor, quickly act on affected part, evade in the prior art, due to the blocking of nail cover, it is difficult to arrive at affected part to lead to curative effect of medication, lead to weak curative effect, slowly effect, refractory technical barrier more.
Description
Technical field
The invention belongs to technical field of pharmaceuticals, more particularly, to treat the drug of onychomycosis and the auxiliary using the drug
A kind of device, and in particular to nail covers and pharmaceutical composition for treating onychomycosis.
Background technology
Nail covers are a kind of small device or auxiliary tool for protecting nail, are all usually using the crowd of nail covers
It is engaged in the people of particular job or particular demands.Such as：Some are engaged in Chinese zither, and the musical instruments such as guitar can make due to carrying out the process of playing
Nail bears very big external force, is easy to cause inordinate wear or the cracking of nail；In order to avoid such case, typically band
Special nail covers or one layer of Protection glue band of package on finger.On the one hand, the work of the protection to nail and finger can be played
With another aspect can avoid having skidded phenomenon when playing.There is no others treatment function and effects, relatively very
It is single.
And the pain that current onychomycosis is brought to patient is clearly, first, be that appearance is plain, after suffering from onychomycosis,
Nail can become color；Second, nail is since lesion can occur for the influence of fungi, nail cover ontology can become very thick very lopsided,
Often nail can be repaired during treatment, it is moulding；Serious or even also need to pull out nail cover, this is not only to suffering from
Person brings apparent influence, while can also bring and very expensive pull out expense and pain.In view of certain treatment onychomycosis
The overall process of disease, the problem of highlighting clearly, have following：One, due to the influence of onychomycosis fungi, nail is produced
Sick change causes nail needs to be pulled out, and entire toe or finger is made to expose, and is easy to grow and infect new bacterium；And
And it is very painful.Secondly, existing onychomycosis drug therapy be typically that drug is directly applied to affected part, but due to the work of people
It is dynamic, drug will soon be wiped, seriously affect therapeutic effect, not obtain effective protection.Thirdly, onychomycosis treating
In the process due to the deformation of nail itself, it is easy to cause patient and generates mood of feeling oneself inferior, be reluctant to go out, the psychology such as sandals dare not be worn and asked
Topic etc..
In view of the presence for the partial technical problems that above-mentioned onychomycosis generates under the effect of existing therapeutic modality, need a kind of same
When take into account the device for the treatment of and defencive function, while being also avoided that the patients ' psychological obstacle caused by nail variation deformation is asked
Topic.
Applicant provides several below and this case belongs to the patent document of same domain, for auditor's notification reference, and provides
Information and abstract are as follows：
The prior art 1：
Chinese utility model patent, application number 201620578021.6, abstract：A kind of false nail set comprising adjustable
When fingerstall and plectrum, the fingerstall includes fixed part and two adjustable sections, and the fixed part is human body finger tip cooperation
Arc-like sheet, and two adjustable sections are the soft metal piece being arranged at fixed part both ends respectively, and one is provided on the fixed part
Arc covers form the cavity that can be inserted into plectrum between the arc covers and fixed part outer surface, positioning is provided in the cavity and is fixed
Structure.Fingerstall is divided into fixed part and adjustable section by the present invention, wherein adjustable section using can be deformed by manually exerting a force from
And reach adjusting purpose, and fixed part is indeformable metal arc-like sheet simultaneously, effectively avoids existing knowing generally soft metal
It is made and causes the defect of overall deformation in adjustment process；Meanwhile it is real by positioning clamping structure cooperation between fingerstall and plectrum
The stability that connection is improved while existing Fast Installation, to improve the physical life of product.
The prior art 2：
Chinese utility model patent, application number：200820081484.7 abstract：A kind of nail covers, including traditional Chinese zither
Nail or play the musical instrument nail and fingerstall two parts, it is important to Plectra on finger for playing zheng or nail of playing the musical instrument are fixed on fingerstall and constituted, nail covers
Inner diameter size is adjustable, and cuff has good stability on finger, is more advantageous to Zither playing activity, and reduction is wrapped up with adhesive plaster
Trouble.
The prior art 3：
Chinese utility model patent, application number：201220074889.4 abstract：The invention discloses a kind of nail covers, it
Including finger-stall, the finger-stall is provided with nail, does not specially have the people of nail or uncomfortable foster nail to use to some, puts on
It after nail covers, can scratch, or some food pericarps are peeled off with nail, pull open drawing lid of some beverages etc., the present invention is directed to carry
For a kind of simple in structure, easy to manufacture, easy to use, lower-cost nail covers.
Above-mentioned is in the prior art to solve existing the problems in play and set up, can not be to existing onychomycosis
Relevant issues generate any effect.
Invention content
Present invention aims at a kind of nail covers and pharmaceutical composition for treating onychomycosis are provided, in order to solve background
Existing nail covers present in technology cannot cannot carry out technology existing for effective protection to drug and ask to the treatment of onychomycosis
Topic.Pharmaceutical composition provided by the invention can than the existing more quick skin permeation of drug for treating onychomycosis and
Nail, fungi existing for the region covered to nail are killed, and to significantly more efficient treatment, Medicated Permeation ability is strong,
Shorten treatment cycle；Meanwhile pharmaceutical composition of the present invention can perfectly coordinate nail covers, and provided using nail covers
Fixation and protection is lasting acts on affected part, improve the effect for the treatment of, avoid artificial activity and lead to the erasing of drug, sternly
It affects the treatment again；Further, the slot hook that devises of nail covers creativeness of the present invention can be good at being mounted on nail
It covers, and realizes and securely fasten, provide good stationarity and aesthetics；The oolemma being arranged in the present invention can be
The problem of removing finger nail and securely installed on the toe head covered, will not being fallen.
The technical solution adopted in the present invention is：
A kind of pharmaceutical composition, including the A agent and B agent that successively use, the constituent content of the A agent are：Terbinafine 1-3
Part, 2-3 parts of bifonazole, 3-6 parts of sealwort, 2-5 parts of folium artemisiae argyi, 1 part of contribution root, 1-2 parts of menthol, 1-2 parts of camphor, povidone iodine
0.2-0.6 parts, 0.1-0.4 parts of brufen；
The constituent content of B agent is：1-3 parts of car fare grass, 2-3.5 parts of alum, 1-2 parts of borneol, 1-4 parts of sodium chloride, sallow is mould
0.5-1.2 parts of plain piece, 1-2 parts of sulphur, 3-5 parts of SEMEN AESCULI；
The preparation method of the A agent is：All A agent components in addition to povidone iodine and brufen are claimed according to mass parts
All medicine materials are implanted into progress physics in broken cup after weight to be crushed, obtain the drug block that area is not more than one square centimeter
Shape carries out hand-crushed using medicinal material plug-in strip；Then by the Bulk drug of acquisition as crushing acquisition powder in grinder
The Chinese medicine of last shape, and thick matter medicinal material is carried out by screening and filtering by filter screen, obtain pure medicinal powder mixture；
It is as high temperature fumigation, stifling condition is carried out in steam copper by medicinal powder mixture：95-100 °C of temperature continues
Time 2-3 hour obtains drug solution, then by the povidone iodine of corresponding mass part and brufen as melting in drug solution
Change, and stir evenly, place into gelling agent when being cooled to 40-50 DEG C, be stirred continuously to cooling, and according to solidifying in whipping process
Gluey state is continuously added gelling agent, is subject to the cream drug for obtaining unnatural trickling；
The preparation method of the B agent is：According to the crushing of A agent, smoked after B agent all components are weighed according to corresponding mass part
It steams and gel step carries out, obtain pasta B agent.
The present invention also provides a kind of nail covers for treating onychomycosis, including nail covers ontology, the width of the nail covers
The arc-shaped laminated structure in direction is spent, length direction both sides of the edge are provided with to curve inwardly and be hooked for accommodating the slot of nail；The finger
First set inner surface is bonded with the buffering medicine pad for the treatment of onychomycosis, the pharmaceutical composition obtained with aforesaid way in the buffering medicine pad
Object.
Action principle：Selection with nail cover size in need for the treatment of be adapted nail covers size, by nail upper shield and
On nail cover, and nail covers are firmly pressed, so that the slot is hooked and fasten the both sides of the edge of nail cover, to reach fixed mesh
's；At this point, the buffering medicine pad on the nail covers inner surface can naturally be filled under compressed state the nail covers with
Gap between nail cover, so that being bonded more consolidation between nail covers and nail cover.Buffer the work that medicine pad can continue
For affected part, therapeutic effect is carried out to onychomycosis.
In order to further fix the nail covers, and the patient suitable for having removed finger nail lid, it is preferable that described
Multiple through-holes are both provided with close to the both sides that the slot hooks on nail covers, straight line where the through-hole is parallel with slot hook, and
It it is 1.5-3 millimeters apart from slot crisperding edge air line distance；It is described to tighten through the band of tightening for being connected with transparent material in the through-hole
Band uses elastic resin adhesive tape or silicone band.Due to many onychomycosis patients since the abnormal shape of nail cover increases, become bended,
It thickens, or even serious obstruction treatment, in this case, it will usually the nail cover of lesion is pulled out, once it is removed by handle
After falling, the slot hook of nail covers cannot hook on nail cover, be fixed to be hooked by slot；In this case can
In a manner of using band fastening is tightened, due to using transparent silicone band or resin tape, it is skin attachement state in this way
There is down preferable hiding, do not affect the appearance effect, while can realize fixed effect again.Silicone band or resin tape
Elasticity it is weaker for rubber adhesive tape, not will produce very tight effect and influence the blood circulation of toe head.
It is excellent in order under the action of meeting fixed, have the wider array of scope of application, and the effect of realization beauty as possible
Selection of land, the width for tightening band are 5 millimeters -10 millimeters, and thickness is 0.2 millimeter -0.6 millimeter, and length is 35 millimeter of -72 milli
Rice.Since the infection scope of onychomycosis is likely to be on toe, it may be possible to which on finger, therefore, the toe head of different people can
There can be difference in size, then there is no need to different length, the size for tightening band of different in width, to meet the need of different patients
It asks.It was verified that when being installed to nail covers, the matching of length and width can very easily be bonded the toe of patient
Therefore thickness limit at 0.2-0.6 millimeters is appearance effect by head, but the difference of thickness can significantly affect the effect of appearance
The best thickness of fruit, in principle under the premise of pursuing appearance, the area of nail covers is bigger, and thickness increases therewith；But it is no matter thick
Degree number do not interfere with the normal performance of therapeutic effect.
In order to expand the scope of application of nail covers, it is preferable that a diameter of 0.8 millimeter of -2 milli of section flexure that the slot hooks
Rice, the central angle that slot hooks crooked radian are 160 ° -180 °.Since the thickness of the nail in sufferer state is not no standard,
Usually over the course for the treatment of, need to carry out nail cover it is certain moulding, nail cover edge thickness generally according to toe head
Situation can carry out certain moulding, to be hooked to slot according to the difference of the crooked radian of moulding thickness difference and nail cover itself need
Seek also different from, but it is usually moulding after the thickness of nail cover all do not exceed 1.5 millimeters, therefore, the bending that slot is hooked is straight
Diameter is set as the maximum 2 millimeters patient demands that disclosure satisfy that the current overwhelming majority, if excessively lopsided nail cover only needs suitably
Trimming can install nail covers and carry out treatment protection.The radian central angle of nail cover under normal circumstances is usually spent at 20 degree -35
Between, that is to say, that the case where being easy for slipping when the radian that slot hooks is less than 150 °, therefore slot is hooked into crooked radian
Central angle is 160 ° -180 °；But it is easy for the problem of slot hook influences whether skin histology occur after more than 180 °.
In order to further make the stickiness of nail covers and toe head, it is preferable that the nail covers are close in installation condition
Toe root end edge, which is connected with, is connected edge strip made of soft material, the section wedgewise of the linking edge strip and with it is described
One end of nail covers connection is compared with big end.Since nail covers have certain thickness, the edge of nail covers is skin contact
During can affect to skin and uncomfortable.It, can be by skin and nail covers shape under the setting of linking edge strip
At naturally seamlessly transitting；The discomfort generated relative to the changing of the relative positions that toe hair is given birth to because of nail covers is avoided, and improves appearance
Compactness and aesthetics.
In order to avoid causing turning over time for nail covers in use, scratch, it is further preferred that the nail covers are opposite
The opposite end of linking edge strip is provided with arc-shaped side, and the section edges of the arc-shaped side are at arc-shaped, and surface is coated with wearing layer.
Due to the material of nail covers generally use relative harder, but hardness generally remains similar to true nail, and this hardness is in reality
Border is lived during use, and scratch is easy tod produce, therefore the arc-shaped side for being easiest to touch other substances in use applies
Coating rubbing-layer can effectively avoid the scuffing of nail covers.
In order to enable ointment it is more lasting act on affected part, obtain better therapeutic effect, the buffering medicine pad is
Coated with cream drug and it is bonded in the sponge of the nail covers inner surface, the thickness of the sponge is 2 millis in its natural state
- 3.5 millimeters of rice.Since onychomycosis illness can directly result in the deformation of nail cover, although people can be to color-changeable shape-changeable after an action of the bowels
Nail cover carry out certain reparation, but still cannot directly be formed with nail covers it is complete be bonded, therefore, in nail cover
The even sponge of surface bonding, can ensure that ointment can be firmly attached on sponge always and continuingly act on affected part, and can
Nail cover and nail covers is set to be bonded well.
Beneficial effects of the present invention are：
(1) pharmaceutical composition of the present invention can more quickly be made drug by adding menthol and camphor
With skin permeation and nail cover cuticula, affected part is quickly acted on, has been evaded in the prior art, due to the blocking of nail cover,
It is difficult to arrive at affected part to lead to curative effect of medication, leads to weak curative effect, slowly effect, refractory technical barrier more.
(2) nail covers of the present invention are hooked by using slot and oolemma can be respectively suitable for nail cover and refer to
The patient that first lid has been pulled out, and can realize reliable fixation, make ointment that can be protected always, lasting effect
In affected part.
(3) present invention is fixed using the silicone band for having elasticity transparent, does not interfere with vision in use
Beauty, and there is good fastening effect, can according to the oolemma of different toe head size selection different models and size
Ensure the blood circulation of fastness and toe head, and by the covering of nail covers, the beauty of external toe can be embodied.
(4) present invention is seamless applying well by that can be realized with toe skin in the linking edge strip of setting, by nail
Set is perfectly bonded with toe head, has better vivid effect, to realize the beauty for ensureing nail covers during treatment
Property, it avoids bringing psychological pressure, especially female patient to patient.
Description of the drawings
Fig. 1 is nail covers structure top view of the present invention；
Fig. 2 is sectional views of the Fig. 1 along A-A；
Fig. 3 is sectional views of the Fig. 1 along B-B nail covers ontologies；
Fig. 4 is whole sectional views of the Fig. 1 along B-B；
Fig. 5 is the structure chart of nail covers in embodiment 3；
Fig. 6 is D plot structures enlarged drawing in Fig. 5；
Fig. 7 is the preferred embodiment structure chart of nail covers in embodiment 3；
Fig. 8 is the scheme of installation of nail covers in embodiment 2；
Fig. 9 is the scheme of installation of nail covers in embodiment 3；
In figure：1- nail covers；2- slots hook；3- buffers medicine pad；4- is connected edge strip；5- arc-shaped sides；6- tightens band；7- toes.
Specific implementation mode
Below in conjunction with the accompanying drawings and specific embodiment the present invention is further elaborated.
Embodiment 1：
A kind of pharmaceutical composition, including the A agent and B agent that successively use, the constituent content of the A agent are：Terbinafine 1-3
Part, 2-3 parts of bifonazole, 3-6 parts of sealwort, 2-5 parts of folium artemisiae argyi, 1 part of contribution root, 1-2 parts of menthol, 1-2 parts of camphor, povidone iodine
0.2-0.6 parts, 0.1-0.4 parts of brufen；
The constituent content of B agent is：1-3 parts of car fare grass, 2-3.5 parts of alum, 1-2 parts of borneol, 1-4 parts of sodium chloride, sallow is mould
0.5-1.2 parts of plain piece, 1-2 parts of sulphur, 3-5 parts of SEMEN AESCULI；
The preparation method of the A agent is：All A agent components in addition to povidone iodine and brufen are claimed according to mass parts
All medicine materials are implanted into progress physics in broken cup after weight to be crushed, obtain the drug block that area is not more than one square centimeter
Shape carries out hand-crushed using medicinal material plug-in strip；Then by the Bulk drug of acquisition as crushing acquisition powder in grinder
The Chinese medicine of last shape, and thick matter medicinal material is carried out by screening and filtering by filter screen, obtain pure medicinal powder mixture；
It is as high temperature fumigation, stifling condition is carried out in steam copper by medicinal powder mixture：95-100 DEG C of temperature continues
Time 2-3 hour obtains drug solution, then by the povidone iodine of corresponding mass part and brufen as melting in drug solution
Change, and stir evenly, place into gelling agent when being cooled to 40-50 DEG C, be stirred continuously to cooling, and according to solidifying in whipping process
Gluey state is continuously added gelling agent, is subject to the cream drug for obtaining unnatural trickling；
The preparation method of the B agent is：According to the crushing of A agent, smoked after B agent all components are weighed according to corresponding mass part
It steams and gel step carries out, obtain pasta B agent.
Drug effect cycle experimental data：
Experiment sample takes 15 people onychomycosis patients to be carried out at the same time experiment, and every group of 3 people, totally 5 groups, the age is 20-40 year
Between.Except the content of menthol, camphor, povidone iodine, brufen is different outer, other drugs component all same.
| Group | Menthol | Camphor | Povidone iodine | Brufen | It averagely takes effect the period | Symptom improves the period |
| A groups | 0 | 0 | 0 | 0 | 45 days | 102 days |
| B groups | 0 | 0 | 0.2 | 0.1 | 42 days | 76 days |
| C groups | 1 | 1 | 0.2 | 0.1 | 27 days | 54 days |
| D groups | 2 | 2 | 0.6 | 0.4 | 18 days | 48 days |
By upper data it is found that above-mentioned menthol and camphor can significantly improve drug effect in week time in affected part
Phase, and the effect of povidone iodine and brufen has certain auxiliary but there is no menthols and camphor tree for the shortening of time cycle
The facilitation of brain is apparent.Here it is now why the externally applied drug of most treatment onychomycosis takes effect especially slow original at present
Cause is exactly usually to be reformed just for the therapeutic efficiency in lesion, has ignored drug to a certain extent and arrives at the suitable of lesion
Smooth degree causes drug effect that cannot act on affected part completely.
Embodiment 2：
The width direction of a kind of nail covers for treating onychomycosis, including 1 ontology of nail covers, the nail covers 1 is in arc
Shape laminated structure, length direction both sides of the edge are provided with to curve inwardly hooks 2 for accommodating the slot of nail；Table in the nail covers 1
Face is bonded with the buffering medicine pad 3 for the treatment of onychomycosis, has pharmaceutical composition described in claim 1 in the buffering medicine pad 3.
Action principle：Selection with nail cover size in need for the treatment of be adapted 1 size of nail covers, by nail covers 1 lid and
On nail cover, and nail covers 1 are firmly pressed, so that the slot is hooked 2 and fasten the both sides of the edge of nail cover, it is fixed to reach
Purpose；At this point, the buffering medicine pad 3 on 1 inner surface of nail covers can fill the nail naturally under compressed state
Gap between set 1 and nail cover, so that being bonded more consolidation between nail covers 1 and nail cover.Buffering medicine pad 3 can be held
Continuous acts on affected part, and therapeutic effect is carried out to onychomycosis.
Embodiment 3：
As the preferred embodiment of the present invention, for the further fixed nail covers on the basis of embodiment 2
1, and the patient suitable for having removed finger nail lid, it is preferable that it is respectively provided with close to the both sides of slot hook 2 on the nail covers 1
There are multiple through-holes, straight line is parallel with slot hook 2 where the through-hole, and it is 1.5-3 millis to hook 2 edge lines distance apart from slot
Rice；Band 6 is tightened through be connected with transparent material in the through-hole, and the band 6 of tightening uses elastic resin adhesive tape or silica gel
Band.It due to many onychomycosis patients since the abnormal shape of nail cover increases, becomes bended, thickens, or even serious obstruction treatment, at this
In the case of kind, it will usually the nail cover of lesion be pulled out, once by after removing, the slot of nail covers 1, which hooks 2, to be hooked
On nail cover, it is fixed to which 2 cannot be hooked by slot；In this case can using tighten band fastening by the way of,
Due to using transparent silicone band or resin tape, it is that there is preferable hiding under skin attachement state in this way, not shadow
Aesthetic effect is rung, while can realize fixed effect again.The elasticity of silicone band or resin tape relative to rubber adhesive tape and
Speech is weaker, not will produce very tight effect and influences the blood circulation of toe head.
It is excellent in order under the action of meeting fixed, have the wider array of scope of application, and the effect of realization beauty as possible
Selection of land, the width for tightening band 6 are 5 millimeters -10 millimeters, and thickness is 0.2 millimeter -0.6 millimeter, and length is 35 millimeter of -72 milli
Rice.Since the infection scope of onychomycosis is likely to be on toe, it may be possible to which on finger, therefore, the toe head of different people can
There can be difference in size, then there is no need to different length, the size for tightening band 6 of different in width, to meet different patients'
Demand.It was verified that when being installed to nail covers 1, the matching of length and width can very easily be bonded patient's
Therefore thickness limit at 0.2-0.6 millimeters is appearance by toe head, but the difference of thickness can significantly affect the effect of appearance
The thickness of best results, in principle under the premise of pursuing appearance, the area of nail covers 1 is bigger, and thickness increases therewith；But no matter
The number of thickness does not interfere with the normal performance of therapeutic effect.
In order to expand the scope of application of nail covers 1, it is preferable that the slot hooks 2 a diameter of 0.8 millimeter of -2 milli of section flexure
Rice, the central angle that slot hooks 2 crooked radians are 160 ° -180 °.Since the thickness of the nail in sufferer state is not no standard,
Usually over the course for the treatment of, need to carry out nail cover it is certain moulding, nail cover edge thickness generally according to toe head
Situation can carry out it is certain moulding, according to moulding thickness is different and the difference of the crooked radian of nail cover itself hooks 2 to slot
Demand also different from, but it is usually moulding after the thickness of nail cover all do not exceed 1.5 millimeters, therefore, slot is hooked to 2 bending
Diameter is set as the maximum 2 millimeters patient demands that disclosure satisfy that the current overwhelming majority, if excessively lopsided nail cover only needs to fit
Treatment protection is carried out when trimming can install nail covers 1.The radian central angle of nail cover under normal circumstances is usually at 20 degree -35
Between degree, that is to say, that the case where being easy for slipping when the radian of slot hook 2 is less than 150 °, therefore slot is hooked into 2 arc of curvature
The central angle of degree is 160 ° -180 °；But it is easy for the problem of slot hook 2 influences whether skin histology occur after more than 180 °.
In order to further make the stickiness of nail covers 1 and toe head, it is preferable that the nail covers 1 are leaned in installation condition
Nearly 7 root end edge of toe, which is connected with, is connected edge strip 4 made of soft material, the section wedgewise of the linking edge strip 4 and
The one end being connect with the nail covers 1 is compared with big end.Since nail covers 1 have certain thickness, the edge of nail covers 1 exists
It can affect to skin during skin contact and uncomfortable.It, can be by skin under the setting of linking edge strip 4
It is formed with nail covers 1 and is naturally seamlessly transitted；It avoids because of the discomfort that nail covers 1 are generated relative to the changing of the relative positions that toe hair is given birth to,
And improve the compactness and aesthetics of appearance.
In order to avoid causing turning over time for nail covers 1 in use, scratch, it is further preferred that 1 phase of the nail covers
Opposite end to being connected edge strip 4 is provided with arc-shaped side 5, and the section edges of the arc-shaped side 5 are at arc-shaped, and surface is coated with resistance to
Grind layer.Due to the material of 1 generally use relative harder of nail covers, but hardness generally remain it is similar to true nail, it is this hard
Degree easy tos produce scratch, therefore be easiest to touch the arc of other substances in use during real life use
Shape side 5, which applies coating rubbing-layer, can effectively avoid the scuffing of nail covers 1.
In order to enable ointment it is more lasting act on affected part, obtain better therapeutic effect, the buffering medicine pad 3 is
Coated with cream drug and it is bonded in the sponge of 1 inner surface of the nail covers, the thickness of the sponge is 2 millis in its natural state
- 3.5 millimeters of rice.Since onychomycosis illness can directly result in the deformation of nail cover, although people can be to color-changeable shape-changeable after an action of the bowels
Nail cover carry out certain reparation, but still cannot directly be formed with nail covers 1 it is complete be bonded, therefore, in nail cover
The even sponge of inner surface bonding, can ensure that ointment can be firmly attached on sponge always and continuingly act on affected part, and energy
Nail cover and nail covers 1 is enough set to be bonded well.
The present invention is not limited to above-mentioned optional embodiment, anyone can show that other are various under the inspiration of the present invention
The product of form, however, make any variation in its shape or structure, it is every to fall into the claims in the present invention confining spectrum
Technical solution, be within the scope of the present invention.
Claims (9)
1. a kind of pharmaceutical composition, which is characterized in that including the A agent successively used and B agent, the constituent content of the A agent is：It is special
Than 1-3 parts of naphthalene sweet smell, 2-3 parts of bifonazole, 3-6 parts of sealwort, 2-5 parts of folium artemisiae argyi, 1 part of contribution root, 1-2 parts of menthol, camphor 1-2
Part, 0.2-0.6 parts of povidone iodine, 0.1-0.4 parts of brufen；
The constituent content of B agent is：1-3 parts of car fare grass, 2-3.5 parts of alum, 1-2 parts of borneol, 1-4 parts of sodium chloride, griseofulvin tablet
0.5-1.2 parts, 1-2 parts of sulphur, 3-5 parts of SEMEN AESCULI；
The preparation method of the A agent is：After all A agent components in addition to povidone iodine and brufen are weighed according to mass parts
All medicine materials are implanted into be crushed in cup and carries out physics and is crushed, obtain area it is blocky no more than one square centimeter of drug or
Person carries out hand-crushed using medicinal material plug-in strip；Then the Bulk drug of acquisition is powdered as acquisition is crushed in grinder
Chinese medicine, and by filter screen by thick matter medicinal material carry out screening and filtering, obtain pure medicinal powder mixture；
It is as high temperature fumigation, stifling condition is carried out in steam copper by medicinal powder mixture：95-100 DEG C of temperature, duration
2-3 hours, drug solution is obtained, then by the povidone iodine of corresponding mass part and brufen as melting in drug solution, and
It stirs evenly, gelling agent is placed into when being cooled to 40-50 DEG C, be stirred continuously to cooling, and according to gel in whipping process
State is continuously added gelling agent, is subject to the cream drug for obtaining unnatural trickling；
The preparation method of the B agent is：After B agent all components are weighed according to corresponding mass part according to the crushing of A agent, it is stifling and
Gel step carries out, and obtains pasta B agent.
2. a kind of nail covers for treating onychomycosis, including nail covers (1) ontology, it is characterised in that：The nail covers (1)
The arc-shaped laminated structure of width direction, length direction both sides of the edge are provided with to curve inwardly hooks (2) for accommodating the slot of nail；Institute
The buffering medicine pad (3) that nail covers (1) inner surface is bonded with treatment onychomycosis is stated, there is claim 1 in the buffering medicine pad (3)
The pharmaceutical composition.
3. a kind of nail covers for treating onychomycosis according to claim 2, it is characterised in that：The nail covers (1)
The upper both sides that (2) are hooked close to the slot are both provided with multiple through-holes, straight line where the through-hole hooked with the slot (2) it is parallel, and
It is 1.5-3 millimeters to hook (2) edge line distance apart from slot；It is described through the band of tightening for being connected with transparent material in the through-hole
It tightens band and uses elastic resin adhesive tape or silicone band.
4. a kind of nail covers for treating onychomycosis according to claim 3, it is characterised in that：The width for tightening band
Degree is 5 millimeters -10 millimeters, and thickness is 0.2 millimeter -0.6 millimeter, and length is 35 millimeters -72 millimeters.
5. a kind of nail covers for treating onychomycosis according to claim 3, it is characterised in that：The slot hooks (2)
A diameter of 0.8 millimeter -2 millimeters of section flexure, the central angle that slot hooks (2) crooked radian are 160 ° -180 °.
6. a kind of nail covers for treating onychomycosis according to claim 2 or 3, it is characterised in that：The nail covers
(1) linking edge strip (4), the linking made of soft material are connected with close to toe (7) root end edge in installation condition
The section wedgewise of edge strip (4) and one end for being connect with the nail covers (1) are compared with big end.
7. a kind of nail covers for treating onychomycosis according to claim 6, it is characterised in that：The nail covers (1)
The opposite end of opposite linking edge strip (4) is provided with arc-shaped side (5), and the section edges of the arc-shaped side (5) are at arc-shaped, and surface
Coated with wearing layer.
8. a kind of nail covers for treating onychomycosis according to claim 2, it is characterised in that：The buffering medicine pad
(3) it is coated with cream drug and to be bonded in the sponge of the nail covers (1) inner surface, the thickness of the sponge is in nature
It is 2 millimeters -3.5 millimeters down.
9. pharmaceutical composition according to claim 1, which is characterized in that be used for external application for curing onychomycosis.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810597566.5A CN108434330A (en) | 2018-06-11 | 2018-06-11 | A kind of nail covers and pharmaceutical composition for treating onychomycosis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810597566.5A CN108434330A (en) | 2018-06-11 | 2018-06-11 | A kind of nail covers and pharmaceutical composition for treating onychomycosis |
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| Publication Number | Publication Date |
|---|---|
| CN108434330A true CN108434330A (en) | 2018-08-24 |
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|---|---|---|---|
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| CN (1) | CN108434330A (en) |
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| CN102974029A (en) * | 2012-11-27 | 2013-03-20 | 王加庆 | Fingernail cover for treating onychomycosis |
| CN103142564A (en) * | 2013-03-01 | 2013-06-12 | 邵武市美菰林卫生用品有限公司 | Pharmaceutical composition for treating tinea pedis and preparation method thereof |
| JP6025184B1 (en) * | 2015-09-25 | 2016-11-16 | 株式会社日本総合研究所 | Artificial nails and artificial nails set |
| CN208852045U (en) * | 2018-06-11 | 2019-05-14 | 王琴 | It is a kind of for treating the nail covers of onychomycosis |
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2018
- 2018-06-11 CN CN201810597566.5A patent/CN108434330A/en active Pending
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| CN101564426A (en) * | 2009-05-27 | 2009-10-28 | 徐光丽 | Medicament for external use for treating onychomycosis |
| CN202478397U (en) * | 2011-12-29 | 2012-10-10 | 武汉市思泰利医疗器械发展有限公司 | Administration finger cot for treatment of onychomycosis |
| CN102974029A (en) * | 2012-11-27 | 2013-03-20 | 王加庆 | Fingernail cover for treating onychomycosis |
| CN103142564A (en) * | 2013-03-01 | 2013-06-12 | 邵武市美菰林卫生用品有限公司 | Pharmaceutical composition for treating tinea pedis and preparation method thereof |
| JP6025184B1 (en) * | 2015-09-25 | 2016-11-16 | 株式会社日本総合研究所 | Artificial nails and artificial nails set |
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