CN108430586B - 用于增强的牙齿美白的过氧化氢增效剂系统 - Google Patents
用于增强的牙齿美白的过氧化氢增效剂系统 Download PDFInfo
- Publication number
- CN108430586B CN108430586B CN201580085351.XA CN201580085351A CN108430586B CN 108430586 B CN108430586 B CN 108430586B CN 201580085351 A CN201580085351 A CN 201580085351A CN 108430586 B CN108430586 B CN 108430586B
- Authority
- CN
- China
- Prior art keywords
- composition
- whitening
- sodium
- agent
- bleach activator
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 230000002087 whitening effect Effects 0.000 title claims abstract description 195
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 title claims description 73
- 239000000203 mixture Substances 0.000 claims abstract description 146
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 93
- 239000007844 bleaching agent Substances 0.000 claims abstract description 80
- 239000012190 activator Substances 0.000 claims abstract description 77
- 230000002272 anti-calculus Effects 0.000 claims abstract description 16
- QSKQNALVHFTOQX-UHFFFAOYSA-M sodium nonanoyloxybenzenesulfonate Chemical compound [Na+].CCCCCCCCC(=O)OC1=CC=CC=C1S([O-])(=O)=O QSKQNALVHFTOQX-UHFFFAOYSA-M 0.000 claims description 48
- -1 pentose sugars Chemical class 0.000 claims description 19
- 239000011734 sodium Substances 0.000 claims description 11
- 229910052708 sodium Inorganic materials 0.000 claims description 10
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 claims description 9
- 235000019818 tetrasodium diphosphate Nutrition 0.000 claims description 9
- 239000002562 thickening agent Substances 0.000 claims description 9
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 7
- 239000002253 acid Substances 0.000 claims description 7
- 235000019832 sodium triphosphate Nutrition 0.000 claims description 7
- 229910019142 PO4 Inorganic materials 0.000 claims description 6
- 229940043256 calcium pyrophosphate Drugs 0.000 claims description 6
- 235000011180 diphosphates Nutrition 0.000 claims description 6
- 235000000346 sugar Nutrition 0.000 claims description 5
- RYCLIXPGLDDLTM-UHFFFAOYSA-J tetrapotassium;phosphonato phosphate Chemical compound [K+].[K+].[K+].[K+].[O-]P([O-])(=O)OP([O-])([O-])=O RYCLIXPGLDDLTM-UHFFFAOYSA-J 0.000 claims description 5
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 claims description 4
- 235000019821 dicalcium diphosphate Nutrition 0.000 claims description 4
- JBKVHLHDHHXQEQ-UHFFFAOYSA-N epsilon-caprolactam Chemical compound O=C1CCCCCN1 JBKVHLHDHHXQEQ-UHFFFAOYSA-N 0.000 claims description 4
- 229920000098 polyolefin Polymers 0.000 claims description 4
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 3
- 239000011575 calcium Substances 0.000 claims description 3
- 229910052791 calcium Inorganic materials 0.000 claims description 3
- 235000001465 calcium Nutrition 0.000 claims description 3
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 2
- 125000003047 N-acetyl group Chemical group 0.000 claims description 2
- BPPGLUCINRNKQV-UHFFFAOYSA-N [Na].CC(=O)OOS(=O)(=O)C1=CC=CC=C1 Chemical compound [Na].CC(=O)OOS(=O)(=O)C1=CC=CC=C1 BPPGLUCINRNKQV-UHFFFAOYSA-N 0.000 claims description 2
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims description 2
- 229960005069 calcium Drugs 0.000 claims description 2
- 239000001506 calcium phosphate Substances 0.000 claims description 2
- RBLGLDWTCZMLRW-UHFFFAOYSA-K dicalcium;phosphate;dihydrate Chemical compound O.O.[Ca+2].[Ca+2].[O-]P([O-])([O-])=O RBLGLDWTCZMLRW-UHFFFAOYSA-K 0.000 claims description 2
- 239000001177 diphosphate Substances 0.000 claims description 2
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 claims description 2
- PATMLLNMTPIUSY-UHFFFAOYSA-N phenoxysulfonyl 7-methyloctanoate Chemical compound CC(C)CCCCCC(=O)OS(=O)(=O)OC1=CC=CC=C1 PATMLLNMTPIUSY-UHFFFAOYSA-N 0.000 claims description 2
- 239000010452 phosphate Substances 0.000 claims description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 2
- 229940045916 polymetaphosphate Drugs 0.000 claims description 2
- 229920001184 polypeptide Polymers 0.000 claims description 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 2
- 229940045919 sodium polymetaphosphate Drugs 0.000 claims description 2
- MIKSWWHQLZYKGU-UHFFFAOYSA-M sodium;2-benzoyloxybenzenesulfonate Chemical compound [Na+].[O-]S(=O)(=O)C1=CC=CC=C1OC(=O)C1=CC=CC=C1 MIKSWWHQLZYKGU-UHFFFAOYSA-M 0.000 claims description 2
- PEVPCUFZCODDGN-UHFFFAOYSA-M sodium;2-dodecanoyloxybenzenesulfonate Chemical compound [Na+].CCCCCCCCCCCC(=O)OC1=CC=CC=C1S([O-])(=O)=O PEVPCUFZCODDGN-UHFFFAOYSA-M 0.000 claims description 2
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 2
- 229910000391 tricalcium phosphate Inorganic materials 0.000 claims description 2
- 235000019731 tricalcium phosphate Nutrition 0.000 claims description 2
- 229940078499 tricalcium phosphate Drugs 0.000 claims description 2
- VSJRDSLPNMGNFG-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate;trihydrate Chemical compound O.O.O.[Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O VSJRDSLPNMGNFG-UHFFFAOYSA-H 0.000 claims description 2
- 229940085658 zinc citrate trihydrate Drugs 0.000 claims description 2
- IRLPACMLTUPBCL-KQYNXXCUSA-N 5'-adenylyl sulfate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OS(O)(=O)=O)[C@@H](O)[C@H]1O IRLPACMLTUPBCL-KQYNXXCUSA-N 0.000 claims 1
- 229940005740 hexametaphosphate Drugs 0.000 claims 1
- 239000004615 ingredient Substances 0.000 description 28
- 238000003860 storage Methods 0.000 description 26
- 150000002978 peroxides Chemical class 0.000 description 23
- 241000283690 Bos taurus Species 0.000 description 20
- 239000000499 gel Substances 0.000 description 16
- 238000000034 method Methods 0.000 description 16
- 238000011282 treatment Methods 0.000 description 15
- 210000003298 dental enamel Anatomy 0.000 description 14
- 239000000796 flavoring agent Substances 0.000 description 14
- 235000013355 food flavoring agent Nutrition 0.000 description 14
- 239000000606 toothpaste Substances 0.000 description 14
- 238000002156 mixing Methods 0.000 description 13
- 229940034610 toothpaste Drugs 0.000 description 13
- 238000009472 formulation Methods 0.000 description 12
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 11
- 239000000872 buffer Substances 0.000 description 11
- 239000000126 substance Substances 0.000 description 11
- 239000010410 layer Substances 0.000 description 10
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 9
- 239000003082 abrasive agent Substances 0.000 description 9
- 230000008859 change Effects 0.000 description 9
- 235000003599 food sweetener Nutrition 0.000 description 9
- 239000000047 product Substances 0.000 description 9
- 239000003765 sweetening agent Substances 0.000 description 9
- 239000007788 liquid Substances 0.000 description 8
- 239000000463 material Substances 0.000 description 8
- 210000000214 mouth Anatomy 0.000 description 8
- 150000004965 peroxy acids Chemical class 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 7
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 7
- 239000004094 surface-active agent Substances 0.000 description 7
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 6
- 239000006172 buffering agent Substances 0.000 description 6
- 238000006243 chemical reaction Methods 0.000 description 6
- 239000003975 dentin desensitizing agent Substances 0.000 description 6
- 150000002148 esters Chemical class 0.000 description 6
- 229920000642 polymer Polymers 0.000 description 6
- 150000003839 salts Chemical class 0.000 description 6
- 125000000217 alkyl group Chemical group 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 229910021485 fumed silica Inorganic materials 0.000 description 5
- 239000006072 paste Substances 0.000 description 5
- 235000021317 phosphate Nutrition 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 102000004190 Enzymes Human genes 0.000 description 4
- 108090000790 Enzymes Proteins 0.000 description 4
- 239000004480 active ingredient Substances 0.000 description 4
- 239000002260 anti-inflammatory agent Substances 0.000 description 4
- 229940121363 anti-inflammatory agent Drugs 0.000 description 4
- 239000004599 antimicrobial Substances 0.000 description 4
- 239000002585 base Substances 0.000 description 4
- 239000004075 cariostatic agent Substances 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 239000000551 dentifrice Substances 0.000 description 4
- 229920001600 hydrophobic polymer Polymers 0.000 description 4
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 4
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 4
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 4
- 235000019345 sodium thiosulphate Nutrition 0.000 description 4
- 239000003381 stabilizer Substances 0.000 description 4
- AQLJVWUFPCUVLO-UHFFFAOYSA-N urea hydrogen peroxide Chemical compound OO.NC(N)=O AQLJVWUFPCUVLO-UHFFFAOYSA-N 0.000 description 4
- 239000011782 vitamin Substances 0.000 description 4
- 229940088594 vitamin Drugs 0.000 description 4
- 229930003231 vitamin Natural products 0.000 description 4
- 235000013343 vitamin Nutrition 0.000 description 4
- FEVALTJSQBFLEU-UHFFFAOYSA-N 1-methyl-4-methylsulfinylbenzene Chemical compound CC1=CC=C(S(C)=O)C=C1 FEVALTJSQBFLEU-UHFFFAOYSA-N 0.000 description 3
- 239000000120 Artificial Saliva Substances 0.000 description 3
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 3
- 208000006558 Dental Calculus Diseases 0.000 description 3
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 3
- 239000004264 Petrolatum Substances 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 3
- 230000032683 aging Effects 0.000 description 3
- 239000003513 alkali Substances 0.000 description 3
- 150000001342 alkaline earth metals Chemical class 0.000 description 3
- 125000000129 anionic group Chemical group 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 229920001525 carrageenan Polymers 0.000 description 3
- 239000003086 colorant Substances 0.000 description 3
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 3
- 239000003623 enhancer Substances 0.000 description 3
- 230000003287 optical effect Effects 0.000 description 3
- 239000007800 oxidant agent Substances 0.000 description 3
- 125000000864 peroxy group Chemical group O(O*)* 0.000 description 3
- 229940066842 petrolatum Drugs 0.000 description 3
- 235000019271 petrolatum Nutrition 0.000 description 3
- 239000000049 pigment Substances 0.000 description 3
- 229920001296 polysiloxane Polymers 0.000 description 3
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 239000003755 preservative agent Substances 0.000 description 3
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 3
- 239000008377 tooth whitener Substances 0.000 description 3
- 239000000080 wetting agent Substances 0.000 description 3
- DTOUUUZOYKYHEP-UHFFFAOYSA-N 1,3-bis(2-ethylhexyl)-5-methyl-1,3-diazinan-5-amine Chemical compound CCCCC(CC)CN1CN(CC(CC)CCCC)CC(C)(N)C1 DTOUUUZOYKYHEP-UHFFFAOYSA-N 0.000 description 2
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 239000004322 Butylated hydroxytoluene Substances 0.000 description 2
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 240000001238 Gaultheria procumbens Species 0.000 description 2
- 235000007297 Gaultheria procumbens Nutrition 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 244000024873 Mentha crispa Species 0.000 description 2
- 235000014749 Mentha crispa Nutrition 0.000 description 2
- 244000246386 Mentha pulegium Species 0.000 description 2
- 235000016257 Mentha pulegium Nutrition 0.000 description 2
- 235000004357 Mentha x piperita Nutrition 0.000 description 2
- FZERHIULMFGESH-UHFFFAOYSA-N N-phenylacetamide Chemical compound CC(=O)NC1=CC=CC=C1 FZERHIULMFGESH-UHFFFAOYSA-N 0.000 description 2
- XCOJIVIDDFTHGB-UEUZTHOGSA-N Perillartine Chemical compound CC(=C)[C@H]1CCC(\C=N\O)=CC1 XCOJIVIDDFTHGB-UEUZTHOGSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 229920000388 Polyphosphate Polymers 0.000 description 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- INVGWHRKADIJHF-UHFFFAOYSA-N Sanguinarin Chemical compound C1=C2OCOC2=CC2=C3[N+](C)=CC4=C(OCO5)C5=CC=C4C3=CC=C21 INVGWHRKADIJHF-UHFFFAOYSA-N 0.000 description 2
- 229920002125 Sokalan® Polymers 0.000 description 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- 238000004061 bleaching Methods 0.000 description 2
- 235000010354 butylated hydroxytoluene Nutrition 0.000 description 2
- 229940095259 butylated hydroxytoluene Drugs 0.000 description 2
- 235000010418 carrageenan Nutrition 0.000 description 2
- 239000000679 carrageenan Substances 0.000 description 2
- 229940113118 carrageenan Drugs 0.000 description 2
- ULDHMXUKGWMISQ-UHFFFAOYSA-N carvone Chemical compound CC(=C)C1CC=C(C)C(=O)C1 ULDHMXUKGWMISQ-UHFFFAOYSA-N 0.000 description 2
- 239000007795 chemical reaction product Substances 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 210000004268 dentin Anatomy 0.000 description 2
- VTIIJXUACCWYHX-UHFFFAOYSA-L disodium;carboxylatooxy carbonate Chemical compound [Na+].[Na+].[O-]C(=O)OOC([O-])=O VTIIJXUACCWYHX-UHFFFAOYSA-L 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 229960004867 hexetidine Drugs 0.000 description 2
- 238000004128 high performance liquid chromatography Methods 0.000 description 2
- 239000007970 homogeneous dispersion Substances 0.000 description 2
- 239000012456 homogeneous solution Substances 0.000 description 2
- 235000001050 hortel pimenta Nutrition 0.000 description 2
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 2
- 239000011630 iodine Substances 0.000 description 2
- 229910052740 iodine Inorganic materials 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- SUMDYPCJJOFFON-UHFFFAOYSA-N isethionic acid Chemical compound OCCS(O)(=O)=O SUMDYPCJJOFFON-UHFFFAOYSA-N 0.000 description 2
- WWOYCMCZTZTIGU-UHFFFAOYSA-L magnesium;2-carboxybenzenecarboperoxoate;hexahydrate Chemical compound O.O.O.O.O.O.[Mg+2].OOC(=O)C1=CC=CC=C1C([O-])=O.OOC(=O)C1=CC=CC=C1C([O-])=O WWOYCMCZTZTIGU-UHFFFAOYSA-L 0.000 description 2
- VHILIAIEEYLJNA-UHFFFAOYSA-N methyl p-tolyl sulfide Chemical compound CSC1=CC=C(C)C=C1 VHILIAIEEYLJNA-UHFFFAOYSA-N 0.000 description 2
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 2
- 239000000178 monomer Substances 0.000 description 2
- FBUKVWPVBMHYJY-UHFFFAOYSA-N nonanoic acid Chemical compound CCCCCCCCC(O)=O FBUKVWPVBMHYJY-UHFFFAOYSA-N 0.000 description 2
- 239000002736 nonionic surfactant Substances 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- ZVVSSOQAYNYNPP-UHFFFAOYSA-N olaflur Chemical compound F.F.CCCCCCCCCCCCCCCCCCN(CCO)CCCN(CCO)CCO ZVVSSOQAYNYNPP-UHFFFAOYSA-N 0.000 description 2
- 229960001245 olaflur Drugs 0.000 description 2
- 230000001590 oxidative effect Effects 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 239000001205 polyphosphate Substances 0.000 description 2
- 235000011176 polyphosphates Nutrition 0.000 description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 2
- NROKBHXJSPEDAR-UHFFFAOYSA-M potassium fluoride Chemical compound [F-].[K+] NROKBHXJSPEDAR-UHFFFAOYSA-M 0.000 description 2
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 description 2
- XXQBEVHPUKOQEO-UHFFFAOYSA-N potassium superoxide Chemical compound [K+].[K+].[O-][O-] XXQBEVHPUKOQEO-UHFFFAOYSA-N 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 239000011775 sodium fluoride Substances 0.000 description 2
- 235000013024 sodium fluoride Nutrition 0.000 description 2
- 229960000414 sodium fluoride Drugs 0.000 description 2
- 229960004711 sodium monofluorophosphate Drugs 0.000 description 2
- 229940045872 sodium percarbonate Drugs 0.000 description 2
- 229940048086 sodium pyrophosphate Drugs 0.000 description 2
- MZSDGDXXBZSFTG-UHFFFAOYSA-M sodium;benzenesulfonate Chemical compound [Na+].[O-]S(=O)(=O)C1=CC=CC=C1 MZSDGDXXBZSFTG-UHFFFAOYSA-M 0.000 description 2
- 235000013599 spices Nutrition 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 description 2
- 229960002799 stannous fluoride Drugs 0.000 description 2
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 2
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 2
- 238000004448 titration Methods 0.000 description 2
- RUVINXPYWBROJD-ONEGZZNKSA-N trans-anethole Chemical compound COC1=CC=C(\C=C\C)C=C1 RUVINXPYWBROJD-ONEGZZNKSA-N 0.000 description 2
- 239000000341 volatile oil Substances 0.000 description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
- LCPVQAHEFVXVKT-UHFFFAOYSA-N 2-(2,4-difluorophenoxy)pyridin-3-amine Chemical compound NC1=CC=CN=C1OC1=CC=C(F)C=C1F LCPVQAHEFVXVKT-UHFFFAOYSA-N 0.000 description 1
- GEZAUFNYMZVOFV-UHFFFAOYSA-J 2-[(2-oxo-1,3,2$l^{5},4$l^{2}-dioxaphosphastannetan-2-yl)oxy]-1,3,2$l^{5},4$l^{2}-dioxaphosphastannetane 2-oxide Chemical compound [Sn+2].[Sn+2].[O-]P([O-])(=O)OP([O-])([O-])=O GEZAUFNYMZVOFV-UHFFFAOYSA-J 0.000 description 1
- TYBHZVUFOINFDV-UHFFFAOYSA-N 2-bromo-6-[(3-bromo-5-chloro-2-hydroxyphenyl)methyl]-4-chlorophenol Chemical compound OC1=C(Br)C=C(Cl)C=C1CC1=CC(Cl)=CC(Br)=C1O TYBHZVUFOINFDV-UHFFFAOYSA-N 0.000 description 1
- UBLAMKHIFZBBSS-UHFFFAOYSA-N 3-Methylbutyl pentanoate Chemical compound CCCCC(=O)OCCC(C)C UBLAMKHIFZBBSS-UHFFFAOYSA-N 0.000 description 1
- XSLBWJPPWWFTQY-UHFFFAOYSA-N 3-hydroperoxypropane-1,2-diol Chemical compound OCC(O)COO XSLBWJPPWWFTQY-UHFFFAOYSA-N 0.000 description 1
- MHKLKWCYGIBEQF-UHFFFAOYSA-N 4-(1,3-benzothiazol-2-ylsulfanyl)morpholine Chemical compound C1COCCN1SC1=NC2=CC=CC=C2S1 MHKLKWCYGIBEQF-UHFFFAOYSA-N 0.000 description 1
- DDFHBQSCUXNBSA-UHFFFAOYSA-N 5-(5-carboxythiophen-2-yl)thiophene-2-carboxylic acid Chemical compound S1C(C(=O)O)=CC=C1C1=CC=C(C(O)=O)S1 DDFHBQSCUXNBSA-UHFFFAOYSA-N 0.000 description 1
- GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- 108010011485 Aspartame Proteins 0.000 description 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- 241000416162 Astragalus gummifer Species 0.000 description 1
- 239000004342 Benzoyl peroxide Substances 0.000 description 1
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 description 1
- 229940123208 Biguanide Drugs 0.000 description 1
- 239000004343 Calcium peroxide Substances 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 239000005973 Carvone Substances 0.000 description 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
- 241000206575 Chondrus crispus Species 0.000 description 1
- 244000223760 Cinnamomum zeylanicum Species 0.000 description 1
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 1
- 235000005979 Citrus limon Nutrition 0.000 description 1
- 244000131522 Citrus pyriformis Species 0.000 description 1
- 240000000560 Citrus x paradisi Species 0.000 description 1
- UDIPTWFVPPPURJ-UHFFFAOYSA-M Cyclamate Chemical compound [Na+].[O-]S(=O)(=O)NC1CCCCC1 UDIPTWFVPPPURJ-UHFFFAOYSA-M 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 229930182827 D-tryptophan Natural products 0.000 description 1
- QIVBCDIJIAJPQS-SECBINFHSA-N D-tryptophane Chemical compound C1=CC=C2C(C[C@@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-SECBINFHSA-N 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- FCEXWTOTHXCQCQ-UHFFFAOYSA-N Ethoxydihydrosanguinarine Natural products C12=CC=C3OCOC3=C2C(OCC)N(C)C(C2=C3)=C1C=CC2=CC1=C3OCO1 FCEXWTOTHXCQCQ-UHFFFAOYSA-N 0.000 description 1
- 244000004281 Eucalyptus maculata Species 0.000 description 1
- 102100022624 Glucoamylase Human genes 0.000 description 1
- 108050008938 Glucoamylases Proteins 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 239000004705 High-molecular-weight polyethylene Substances 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- SPAGIJMPHSUYSE-UHFFFAOYSA-N Magnesium peroxide Chemical compound [Mg+2].[O-][O-] SPAGIJMPHSUYSE-UHFFFAOYSA-N 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 244000227633 Ocotea pretiosa Species 0.000 description 1
- 235000004263 Ocotea pretiosa Nutrition 0.000 description 1
- 235000011203 Origanum Nutrition 0.000 description 1
- 241001529744 Origanum Species 0.000 description 1
- 239000005643 Pelargonic acid Substances 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 229910006069 SO3H Inorganic materials 0.000 description 1
- WINXNKPZLFISPD-UHFFFAOYSA-M Saccharin sodium Chemical compound [Na+].C1=CC=C2C(=O)[N-]S(=O)(=O)C2=C1 WINXNKPZLFISPD-UHFFFAOYSA-M 0.000 description 1
- 240000001058 Sterculia urens Species 0.000 description 1
- 235000015125 Sterculia urens Nutrition 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 239000005844 Thymol Substances 0.000 description 1
- 235000011941 Tilia x europaea Nutrition 0.000 description 1
- 240000006909 Tilia x europaea Species 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 1
- 241000219793 Trifolium Species 0.000 description 1
- 229920001807 Urea-formaldehyde Polymers 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- CANRESZKMUPMAE-UHFFFAOYSA-L Zinc lactate Chemical compound [Zn+2].CC(O)C([O-])=O.CC(O)C([O-])=O CANRESZKMUPMAE-UHFFFAOYSA-L 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 229960001413 acetanilide Drugs 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 229960001138 acetylsalicylic acid Drugs 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- LFVVNPBBFUSSHL-UHFFFAOYSA-N alexidine Chemical compound CCCCC(CC)CNC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NCC(CC)CCCC LFVVNPBBFUSSHL-UHFFFAOYSA-N 0.000 description 1
- 229950010221 alexidine Drugs 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- SNAAJJQQZSMGQD-UHFFFAOYSA-N aluminum magnesium Chemical compound [Mg].[Al] SNAAJJQQZSMGQD-UHFFFAOYSA-N 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 235000019826 ammonium polyphosphate Nutrition 0.000 description 1
- 239000002280 amphoteric surfactant Substances 0.000 description 1
- 229940011037 anethole Drugs 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- 229940027983 antiseptic and disinfectant quaternary ammonium compound Drugs 0.000 description 1
- 239000000605 aspartame Substances 0.000 description 1
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 1
- 235000010357 aspartame Nutrition 0.000 description 1
- 229960003438 aspartame Drugs 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 229910052788 barium Inorganic materials 0.000 description 1
- DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 description 1
- ZJRXSAYFZMGQFP-UHFFFAOYSA-N barium peroxide Chemical compound [Ba+2].[O-][O-] ZJRXSAYFZMGQFP-UHFFFAOYSA-N 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 235000019400 benzoyl peroxide Nutrition 0.000 description 1
- 235000019445 benzyl alcohol Nutrition 0.000 description 1
- 229960004217 benzyl alcohol Drugs 0.000 description 1
- 150000004283 biguanides Chemical class 0.000 description 1
- IISBACLAFKSPIT-UHFFFAOYSA-N bisphenol A Chemical class C=1C=C(O)C=CC=1C(C)(C)C1=CC=C(O)C=C1 IISBACLAFKSPIT-UHFFFAOYSA-N 0.000 description 1
- 230000001680 brushing effect Effects 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- WUKWITHWXAAZEY-UHFFFAOYSA-L calcium difluoride Chemical compound [F-].[F-].[Ca+2] WUKWITHWXAAZEY-UHFFFAOYSA-L 0.000 description 1
- 229910001634 calcium fluoride Inorganic materials 0.000 description 1
- LHJQIRIGXXHNLA-UHFFFAOYSA-N calcium peroxide Chemical compound [Ca+2].[O-][O-] LHJQIRIGXXHNLA-UHFFFAOYSA-N 0.000 description 1
- 235000019402 calcium peroxide Nutrition 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 150000007942 carboxylates Chemical class 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 229960001927 cetylpyridinium chloride Drugs 0.000 description 1
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 1
- 229960003260 chlorhexidine Drugs 0.000 description 1
- 235000017803 cinnamon Nutrition 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical group CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 description 1
- 229940073507 cocamidopropyl betaine Drugs 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000007859 condensation product Substances 0.000 description 1
- 150000001879 copper Chemical class 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 229920006037 cross link polymer Polymers 0.000 description 1
- 239000000625 cyclamic acid and its Na and Ca salt Substances 0.000 description 1
- 239000012933 diacyl peroxide Substances 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- LRCFXGAMWKDGLA-UHFFFAOYSA-N dioxosilane;hydrate Chemical compound O.O=[Si]=O LRCFXGAMWKDGLA-UHFFFAOYSA-N 0.000 description 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-N diphosphoric acid Chemical compound OP(O)(=O)OP(O)(O)=O XPPKVPWEQAFLFU-UHFFFAOYSA-N 0.000 description 1
- IRXRGVFLQOSHOH-UHFFFAOYSA-L dipotassium;oxalate Chemical compound [K+].[K+].[O-]C(=O)C([O-])=O IRXRGVFLQOSHOH-UHFFFAOYSA-L 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- 235000019820 disodium diphosphate Nutrition 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- GYQBBRRVRKFJRG-UHFFFAOYSA-L disodium pyrophosphate Chemical compound [Na+].[Na+].OP([O-])(=O)OP(O)([O-])=O GYQBBRRVRKFJRG-UHFFFAOYSA-L 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000010494 dissociation reaction Methods 0.000 description 1
- GVGUFUZHNYFZLC-UHFFFAOYSA-N dodecyl benzenesulfonate;sodium Chemical compound [Na].CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 GVGUFUZHNYFZLC-UHFFFAOYSA-N 0.000 description 1
- 125000006575 electron-withdrawing group Chemical group 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000002191 fatty alcohols Chemical class 0.000 description 1
- 230000009969 flowable effect Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 229960002390 flurbiprofen Drugs 0.000 description 1
- SYTBZMRGLBWNTM-UHFFFAOYSA-N flurbiprofen Chemical compound FC1=CC(C(C(O)=O)C)=CC=C1C1=CC=CC=C1 SYTBZMRGLBWNTM-UHFFFAOYSA-N 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 229940083124 ganglion-blocking antiadrenergic secondary and tertiary amines Drugs 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 150000002432 hydroperoxides Chemical class 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 229960001680 ibuprofen Drugs 0.000 description 1
- 125000005462 imide group Chemical group 0.000 description 1
- 229960000905 indomethacin Drugs 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 239000004571 lime Substances 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- HPGPEWYJWRWDTP-UHFFFAOYSA-N lithium peroxide Chemical compound [Li+].[Li+].[O-][O-] HPGPEWYJWRWDTP-UHFFFAOYSA-N 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- ORUIBWPALBXDOA-UHFFFAOYSA-L magnesium fluoride Chemical compound [F-].[F-].[Mg+2] ORUIBWPALBXDOA-UHFFFAOYSA-L 0.000 description 1
- 229910001635 magnesium fluoride Inorganic materials 0.000 description 1
- 229960004995 magnesium peroxide Drugs 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical group C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 description 1
- 229960000282 metronidazole Drugs 0.000 description 1
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000002324 mouth wash Substances 0.000 description 1
- 229940051866 mouthwash Drugs 0.000 description 1
- 229920001206 natural gum Polymers 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 229960001774 octenidine Drugs 0.000 description 1
- SMGTYJPMKXNQFY-UHFFFAOYSA-N octenidine dihydrochloride Chemical compound Cl.Cl.C1=CC(=NCCCCCCCC)C=CN1CCCCCCCCCCN1C=CC(=NCCCCCCCC)C=C1 SMGTYJPMKXNQFY-UHFFFAOYSA-N 0.000 description 1
- 239000011368 organic material Substances 0.000 description 1
- 150000004967 organic peroxy acids Chemical class 0.000 description 1
- MPQXHAGKBWFSNV-UHFFFAOYSA-N oxidophosphanium Chemical group [PH3]=O MPQXHAGKBWFSNV-UHFFFAOYSA-N 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- RARSHUDCJQSEFJ-UHFFFAOYSA-N p-Hydroxypropiophenone Chemical compound CCC(=O)C1=CC=C(O)C=C1 RARSHUDCJQSEFJ-UHFFFAOYSA-N 0.000 description 1
- 238000010422 painting Methods 0.000 description 1
- RUVINXPYWBROJD-UHFFFAOYSA-N para-methoxyphenyl Natural products COC1=CC=C(C=CC)C=C1 RUVINXPYWBROJD-UHFFFAOYSA-N 0.000 description 1
- 125000005342 perphosphate group Chemical group 0.000 description 1
- JRKICGRDRMAZLK-UHFFFAOYSA-L persulfate group Chemical group S(=O)(=O)([O-])OOS(=O)(=O)[O-] JRKICGRDRMAZLK-UHFFFAOYSA-L 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 229920005646 polycarboxylate Polymers 0.000 description 1
- ODGAOXROABLFNM-UHFFFAOYSA-N polynoxylin Chemical compound O=C.NC(N)=O ODGAOXROABLFNM-UHFFFAOYSA-N 0.000 description 1
- 229920000056 polyoxyethylene ether Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229960003975 potassium Drugs 0.000 description 1
- AVTYONGGKAJVTE-OLXYHTOASA-L potassium L-tartrate Chemical compound [K+].[K+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O AVTYONGGKAJVTE-OLXYHTOASA-L 0.000 description 1
- 235000015497 potassium bicarbonate Nutrition 0.000 description 1
- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 1
- 239000011736 potassium bicarbonate Substances 0.000 description 1
- 229940094025 potassium bicarbonate Drugs 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 229960002816 potassium chloride Drugs 0.000 description 1
- 239000001508 potassium citrate Substances 0.000 description 1
- 229960002635 potassium citrate Drugs 0.000 description 1
- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 description 1
- 235000011082 potassium citrates Nutrition 0.000 description 1
- 239000011698 potassium fluoride Substances 0.000 description 1
- 235000003270 potassium fluoride Nutrition 0.000 description 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
- 235000010333 potassium nitrate Nutrition 0.000 description 1
- 239000004323 potassium nitrate Substances 0.000 description 1
- 239000001472 potassium tartrate Substances 0.000 description 1
- 229940111695 potassium tartrate Drugs 0.000 description 1
- 235000011005 potassium tartrates Nutrition 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- FBCQUCJYYPMKRO-UHFFFAOYSA-N prop-2-enyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCC=C FBCQUCJYYPMKRO-UHFFFAOYSA-N 0.000 description 1
- 239000011241 protective layer Substances 0.000 description 1
- 229940048084 pyrophosphate Drugs 0.000 description 1
- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000012744 reinforcing agent Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 235000002020 sage Nutrition 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 229940084560 sanguinarine Drugs 0.000 description 1
- YZRQUTZNTDAYPJ-UHFFFAOYSA-N sanguinarine pseudobase Natural products C1=C2OCOC2=CC2=C3N(C)C(O)C4=C(OCO5)C5=CC=C4C3=CC=C21 YZRQUTZNTDAYPJ-UHFFFAOYSA-N 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229960004029 silicic acid Drugs 0.000 description 1
- 229960001866 silicon dioxide Drugs 0.000 description 1
- 229960001462 sodium cyclamate Drugs 0.000 description 1
- 229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 description 1
- PFUVRDFDKPNGAV-UHFFFAOYSA-N sodium peroxide Chemical compound [Na+].[Na+].[O-][O-] PFUVRDFDKPNGAV-UHFFFAOYSA-N 0.000 description 1
- CHQMHPLRPQMAMX-UHFFFAOYSA-L sodium persulfate Substances [Na+].[Na+].[O-]S(=O)(=O)OOS([O-])(=O)=O CHQMHPLRPQMAMX-UHFFFAOYSA-L 0.000 description 1
- UGTZMIPZNRIWHX-UHFFFAOYSA-K sodium trimetaphosphate Chemical compound [Na+].[Na+].[Na+].[O-]P1(=O)OP([O-])(=O)OP([O-])(=O)O1 UGTZMIPZNRIWHX-UHFFFAOYSA-K 0.000 description 1
- YKOLYTVUIVUUDY-UHFFFAOYSA-K sodium;zinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Na+].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O YKOLYTVUIVUUDY-UHFFFAOYSA-K 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 159000000008 strontium salts Chemical class 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 150000003871 sulfonates Chemical class 0.000 description 1
- 150000003462 sulfoxides Chemical class 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- FRPJTGXMTIIFIT-UHFFFAOYSA-N tetraacetylethylenediamine Chemical compound CC(=O)C(N)(C(C)=O)C(N)(C(C)=O)C(C)=O FRPJTGXMTIIFIT-UHFFFAOYSA-N 0.000 description 1
- 229960000790 thymol Drugs 0.000 description 1
- 235000019505 tobacco product Nutrition 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- UNXRWKVEANCORM-UHFFFAOYSA-I triphosphate(5-) Chemical compound [O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O UNXRWKVEANCORM-UHFFFAOYSA-I 0.000 description 1
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
- 239000011746 zinc citrate Substances 0.000 description 1
- 235000006076 zinc citrate Nutrition 0.000 description 1
- 229940068475 zinc citrate Drugs 0.000 description 1
- 229940071566 zinc glycinate Drugs 0.000 description 1
- 239000011576 zinc lactate Substances 0.000 description 1
- 235000000193 zinc lactate Nutrition 0.000 description 1
- 229940050168 zinc lactate Drugs 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- 229960001296 zinc oxide Drugs 0.000 description 1
- 235000014692 zinc oxide Nutrition 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- 229960001763 zinc sulfate Drugs 0.000 description 1
- 229910000368 zinc sulfate Inorganic materials 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
- UOXSXMSTSYWNMH-UHFFFAOYSA-L zinc;2-aminoacetate Chemical compound [Zn+2].NCC([O-])=O.NCC([O-])=O UOXSXMSTSYWNMH-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/22—Peroxides; Oxygen; Ozone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/26—Aluminium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/38—Percompounds, e.g. peracids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- A61Q11/02—Preparations for deodorising, bleaching or disinfecting dentures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/88—Two- or multipart kits
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/95—Involves in-situ formation or cross-linking of polymers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Emergency Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dispersion Chemistry (AREA)
- Cosmetics (AREA)
Abstract
本发明提供一种牙齿美白组合物,其包含至少一种美白剂、至少一种漂白活化剂、至少一种研磨剂和至少一种抗牙结石剂。
Description
背景技术
本文公开了包含用于增强美白的漂白活化剂的新型组合物,诸如牙齿美白组合物。
在哺乳动物中,牙齿包括内牙本质层和外硬牙釉质层,所述外硬牙釉质层是牙齿的保护层。牙齿的牙釉质层生来是不透明的白色或稍微灰白色。牙釉质层可能着色或脱色,但牙本质层也可能着色,经证实,这种情况会随着时间的推移而自然发生。牙齿的牙釉质层由在某种程度上产生多孔表面的羟基磷灰石矿物晶体组成。这些羟基磷灰石晶体形成细微的六角形棒条体或棱柱体来组成牙釉质表面。因此,牙釉质层的表面在棱柱体之间存在细微空间或气孔。据信牙釉质层的此多孔性质允许着色剂和脱色物质渗入牙釉质并使牙齿脱色。这些残留物质可占据细微空间并最终改变牙齿的颜色。
人们每天碰到或接触的许多物质可能使其牙齿着色或减小其牙齿的洁白度。具体地说,一个人摄入的食物、烟草产品和流体易于使其牙齿着色。这些产品或物质易于积累在牙齿的牙釉质层上并且在牙齿上形成菌膜。
这些着色和脱色物质然后可以渗入牙釉质层。此问题在许多年内逐渐发生,但致使人们牙齿的牙釉质明显变色。只要脱色的牙齿仍然健康并且不会造成任何健康风险或问题,那么会使脱色的牙齿美白的产品或物质将是有利的。消费者在家或私下使用的牙齿美白产品还必须是安全的并容易使用的并且在其零售架上保存期间以及在消费者使用时间段内是稳定的,并且保持其美白功效。
目前可用于使牙齿美白的产品和物质(称为牙齿美白组合物)可包含被配制成液体、糊剂或凝胶载体的多种不同成分。此类产品和物质中提供美白作用的主要活性成分(称为美白剂)是通过氧化牙齿的有机基质而使牙齿美白的过氧化物。
本领域需要相比传统牙齿美白剂增强美白作用。因此,本领域需要改进的牙齿美白组合物,其与目前的商业产品相比可以提供优异的美白益处,并且需要用于储存和提供此类改进的牙齿美白组合物的牙齿美白系统。
发明内容
在一个实施方案中,存在一种牙齿美白组合物,该牙齿美白组合物包含至少一种美白剂和至少一种漂白活化剂。
在另一个实施方案中,存在使牙齿表面美白的方法。该方法包括:使牙齿表面与牙齿美白组合物接触足以使牙齿表面美白的持续时间。该组合物包含至少一种美白剂和至少一种漂白活化剂。
在另一个实施方案中,存在一种用于制备牙齿美白组合物的方法。该方法包括:将至少一种美白剂和至少一种包含活化酯的漂白活化剂在基本上无水混合物中组合。
本发明的其他适用领域从下文提供的详细说明中将变得显而易见。应了解,详细说明和特定实例虽然指示本发明的优选实施方案,但旨在仅用于说明的目的而无意限制本发明的范围。
具体实施方式
以下对优选实施方案的描述在本质上仅是示例性的,并且决不意图限制本发明、本发明的应用或用途。
如通篇所用,范围用作描述范围内的每个值的简略表达方式。范围内的任何值都可选为范围终点。另外,本文引用的所有参考文献据此全文以引用方式并入。在本公开内容中的定义和所引用参考文献的定义冲突的情况下,以本公开内容为准。
除非另外规定,否则本文和在本说明书中其他处表达的所有百分比和量应理解为是指重量百分比。给定的量是基于材料的有效重量计。
本文公开了包含至少一种美白剂和至少一种包含活化酯的漂白活化剂的牙齿美白组合物。本文还公开了可包含作为第一组分的美白剂和作为第二组分的漂白活化剂的多组分(例如双组分)牙齿美白系统。第一组分和第二组分可以保持分离,例如设置在分开的储存腔室中,例如设置在多组分产品分配器的分开的腔室中。在组合第一组分和第二组分后,可以形成牙齿美白组合物。在一个实施方案中,牙齿美白系统还可以包括连接到第一储存腔室和第二储存腔室两者的混合腔室,该混合腔室接收来自第一储存腔室和第二储存腔室的内容物并将它们充分地混合。与包含美白剂但不含漂白活化剂的牙齿组合物相比,这种牙齿美白组合物可以提供优异和更快的美白作用。本文公开的牙齿美白组合物还可包含其他额外成分,所述额外成分包括本领域技术人员已知的那些成分,包括以下组分中的一种或多种:氟离子源、表面活性剂、调味剂、甜味剂、脱敏剂、抗微生物剂、抗龋剂、抗牙结石剂、牙垢控制剂、抗炎剂、缓冲剂、维生素、颜料和脱敏剂、防腐剂以及酶类,如将在下文中更详细地讨论的。
在一些实施方案中,本文公开的牙齿美白组合物、第一组分、第二组分、漂白活化剂和美白剂是粘性液体,诸如凝胶,从而使得产品能够诸如使用软涂敷器笔或刷或牙托施加于牙齿表面。在一个实施方案中,美白剂和漂白活化剂中的至少一种可以与口腔可接受的媒介物组合,然后进一步相互组合以形成可包含洁齿剂的牙齿美白组合物。此类洁齿剂可包括牙科用片剂、牙膏(牙齿乳膏)、牙粉或凝胶或本领域技术人员已知的任何其他形式。如本文所用,“口腔可接受的媒介”是指能安全用于本公开的组合物中、与合理的效险比相称的材料或材料组合,而美白剂和其他所需的活性成分可与它们相结合同时保持显著的功效。
在一些实施方案中,本文公开的牙齿美白组合物是基本上无水的,这意味着基本上不添加水。实施方案的牙齿美白组合物可包含来自成分或产品制造的痕量水平的水;然而,此类痕量水平是少量的并且不会干扰牙齿美白组合物的稳定性。在一个实施方案中,媒介物是低水含量的口腔可接受的媒介物并且可包含任何已知成分或添加剂。例如,媒介物可包括甘油和山梨糖醇的液体混合物。
牙齿美白组合物可以通过混合美白剂和漂白活化剂而形成。美白剂可以是第一组分,而漂白活化剂可以是多组分牙齿美白系统的第二组分,例如本文所述的多组分牙齿美白系统。在该方法中,美白剂和漂白活化剂可以例如通过组合从其分开的储存腔室提供的美白剂和漂白活化剂而混合,以形成牙齿美白组合物。在一个实例中,美白剂和漂白活化剂在诸如牙托之类的涂敷器之中或之上混合。
如下面进一步详述的那样,美白剂和漂白活化剂可以分开储存直至使用时间,例如直至将它们混合在一起以形成牙齿美白组合物。在使用时间之前(例如在它们被混合以形成牙齿美白组合物之前),两种组分(即设置在分开的储存腔室中的美白剂和漂白活化剂)的分开使美白剂过氧化物和漂白活化剂每一者的稳定性增加。
本文所述的牙齿美白组合物可包含第一组分,如至少一种美白剂;以及第二组分,如至少一种漂白活化剂。漂白活化剂可以包含活化酯。第一组分和第二组分中的每一者还可包含其他额外成分,所述额外成分包括本领域技术人员已知的那些成分,包括以下组分中的一种或多种:氟离子源、表面活性剂、调味剂、甜味剂、脱敏剂、抗微生物剂、抗龋剂、抗牙结石剂、牙垢控制剂、抗炎剂、缓冲剂、维生素、颜料和脱敏剂、防腐剂以及酶类,如将在下文中更详细地讨论的。可以将缓冲剂与美白剂和/或与漂白活化剂一起添加到它们各自的分开的储存腔室中,或经由另外的储存腔室添加,使得混合第一组分和第二组分形成具有适当的pH(例如碱性pH)的牙齿美白组合物,以实现美白剂与漂白活化剂之间的最大反应。在一个实施方案中,可将至少一种缓冲剂分别添加到第一储存腔室和第二储存腔室中的美白剂和/或漂白活化剂,并且第一储存腔室中的美白剂所含的至少一种缓冲剂可以与第二储存腔室中随漂白活化剂添加的至少一种缓冲剂不同。这些额外成分中的任何一种或多种可以包含在含有牙齿美白剂的第一组分和/或含有漂白活化剂的第二组分中。第一组分中可以包含与第二组分中相同或不同的一种或多种这些额外成分。
美白剂
在多种实施方案中,本文公开的牙齿美白组合物包含至少一种美白剂作为主要活性成分。在某些实施方案中,所述至少一种美白剂是过氧化物化合物。如下文中进一步讨论的,“美白剂”是使施加它的牙齿表面实现美白的材料。
如本文所提及的,“过氧化物化合物”是包含二价氧-氧基团的氧化化合物。过氧化物化合物包括过氧化物和氢过氧化物,诸如过氧化氢、碱金属和碱土金属的过氧化物、有机过氧化合物、过氧酸、其药学上可接受的盐及其混合物。碱金属和碱土金属的过氧化物包括过氧化锂、过氧化钾、过氧化钠、过氧化镁、过氧化钙、过氧化钡及其混合物。有机过氧化合物包括过氧化脲(也称为脲过氧化氢)、甘油基过氧化氢、烷基过氧化氢、二烷基过氧化物、烷基过氧酸、过氧酯、二酰基过氧化物、过氧化苯甲酰以及单过氧邻苯二甲酸盐及其混合物。过氧酸及其盐包括有机过氧酸诸如烷基过氧酸,以及单过氧邻苯二甲酸盐及其混合物,以及无机过氧酸盐,诸如碱金属和碱土金属诸如锂、钾、钠、镁、钙和钡的过硫酸盐、二过硫酸盐、过碳酸盐、过磷酸盐、过硼酸盐和过硅酸盐,及其混合物。在多种实施方案中,过氧化物化合物包括过氧化氢、过氧化脲、过碳酸钠及其混合物。
可提及用于本文公开的牙齿美白组合物中的过氧化物释放化合物包括含有过氧化物的化合物,诸如过氧化脲、过碳酸钠、过硫酸钠以及聚乙烯吡咯烷酮-H2O2复合物(在下文中为“PVP-H2O2”)。聚乙烯吡咯烷酮也称为聚-N-乙烯基-聚-2-吡咯烷酮并且通常缩写为“PVP”。PVP通常是指含有乙烯基吡咯烷酮(也称为N-乙烯基吡咯烷酮、N-乙烯基-2-吡咯烷酮和N-乙烯基-2-吡咯烷酮)作为单体单元的聚合物。该单体单元由一个极性酰亚胺基团、四个非极性亚甲基基团和一个非极性甲烷基团组成。
PVP-H2O2的线性和交联复合物是本领域中已知的,并且PVP-H2O2被认为在无水环境中是稳定的。在暴露于高度水性环境时,诸如在口腔中,PVP-H2O2解离成单独物质(PVP聚合物和H2O2)。在一个实施方案中,PVP-H2O2复合物按重量计80%是聚乙烯吡咯烷酮并且按重量计20%是H2O2。
在本文公开的替代性实施方案中,所述至少一种美白剂包括液体过氧化物溶液。美白组合物的疏水性聚合物载体提供足够的稳定性以允许使用液体过氧化氢。液体过氧化氢包含H2O2,其通常包含在水性水基溶液中。在一些实施方案中,液体过氧化氢具有的过氧化物与总溶液的浓度范围为按重量计约0.035%至约17.5%,诸如约3%至约10%,其例如可通过添加以下浓度的35重量%水性H2O2溶液来实现:约0.1重量%至约50重量%,诸如约8重量%至约29重量%或约15重量%至约25重量%。在一个实施方案中,实施方案的牙齿美白组合物包含1%的美白剂,其可以是PVP-H2O2复合物的形式。
另外,至少一种稳定剂可以与包含美白剂的组合物一起存在。例如,可使用具有约0.1%至约0.5%的至少一种稳定剂的3%过氧化氢溶液。也可使用乙酰苯胺或类似有机材料以及焦磷酸盐稳定剂诸如酸式焦磷酸钠,所述稳定剂存在的量的范围为约0.1%至约1.0%,诸如约0.5%。
在某些实施方案中,牙齿美白组合物还可包含增强过氧化物作为过氧化物组分美白剂的一部分在口腔中释放的至少一种试剂。在一个实施方案中,增强口腔中过氧化物释放的所述至少一种试剂可以在第一容器中与牙齿美白剂一起提供,在第二容器中或在第三容器中与漂白活化剂一起提供,它们在使用牙齿美白组合物时与美白剂和/或漂白活化剂混合。可得自Amcol health&Beauty Solutions,Inc.的Polypore(一种甲基丙烯酸烯丙酯交联聚合物)是示例性增强剂。
在多种实施方案中,所述至少一种美白剂存在于牙齿美白组合物中的量相对于牙齿美白组合物的总重量按重量计为最高约35%,包括约0.035%至17.5%,诸如低于或等于约10%且大于约0%,包括约0%至约0.1%、约0.1%至约10%或约0.1%至约6%,包括约1%。因此,可以预先选择设置在第一储存腔室中的第一组分中的牙齿美白剂的浓度,和/或可以在从第一储存腔室排出时控制第一组分的体积,从而在通过组合牙齿美白剂和漂白活化剂而形成的牙齿美白组合物中提供上述量的美白剂。
在本文所公开的实施方案中,所述至少一种美白剂可以是过氧化氢,并且在某些示例性实施方案中,过氧化氢可存在于牙齿美白组合物中的量的范围为相对于组合物总重量按重量计约0.1%至约10%,例如约0.1%至约3%,包括约1%和2%。因此,可以预先选择设置在第一储存腔室中的第一组分中的过氧化氢的浓度,和/或可以在从第一储存腔室排出时控制第一组分的体积,从而在通过组合过氧化氢和漂白活化剂而形成的牙齿美白组合物中提供上述量的过氧化氢。
漂白活化剂
过酸是比过氧化氢更好的氧化剂,并因此提供优异的美白益处。可以作为实施方案的牙齿美白组合物的主要活性成分的美白剂(如上述过氧化物)因此可以与漂白活化剂(如活化酯)反应以形成牙齿美白组合物,漂白活化剂可以是过酸并且可以用于增强漂白效果。
在一个实施方案中,牙齿美白组合物(可以是无水的)可以暴露于含水环境中,例如在将牙齿美白组合物施用于口腔中期间。
在一个实施方案中,牙齿美白组合物因此可通过将可包含美白剂的第一组分和可包含漂白活化剂的第二组分组合而形成。为了保持美白剂和漂白活化剂中的每一者稳定,或使它们彼此不发生反应,可以将它们各自保持在分开的储存容器中直至使用时间,此时它们被组合以形成牙齿美白组合物。然而,为了实现形成牙齿美白组合物的美白剂与漂白活化剂之间的最大反应,第一组分、第二组分或第一组分和第二组分两者可以分别单独包含除美白剂和漂白活化剂外的至少一种缓冲剂。美白剂也可以作为含水组合物提供。因此,当将包含美白剂(可能还有至少一种第一缓冲剂)的含水组合物的第一组分与包含漂白活化剂(可能还有可与第一缓冲剂相同或不同的至少一种第二缓冲剂)的第二组分组合,该组合可以在合适的pH下进行以使反应产物(例如牙齿美白组合物)最大化。暴露于另外的含水环境例如口腔可以进一步提供合适的pH值,以在组合两种组分后使反应产物最大化并由此增强美白作用。
漂白活化剂可以在适当的pH下(例如在3pH至12pH的范围内)与美白剂反应。示例性pH值可以包括大于约5.5pH且小于或等于约9pH的pH,例如在约5.5pH至约6pH的范围内,包括大于约6pH且小于或等于约9pH的pH。在一个实施方案中,漂白活化剂可以在约6pH至约8pH范围内的pH下(例如约7.5pH的pH下)与过氧化物反应。当储存在例如第一储存腔室中时,包含美白剂的第一组分可保持在酸性pH下(即,小于约7pH)。同时,包含漂白活化剂的第二组合物可以是无水的,并因此可能不基于相应的pH来表征。然而,第二组分还可以包含缓冲剂,在混合第一组分和第二组分以形成牙齿美白组合物时,该缓冲剂与储存在第一储存腔室中的第一组分的pH相比提供牙齿美白组合物的更高的pH。
漂白活化剂可以根据一般反应方案1与过氧化物反应:
其中L可以是任何离去基团,包括-O-R'或-NR”R’,其中R可以是任何烷基或芳基,其中烷基可以包括C1至C30例如C1至C8的重复单元,而R”可以是氢或任何烷基或芳基,其中烷基可以包括C1至C30例如C1至C8的重复单元。另外,在式(I)中,R可以是支链或直链烷基,包括C1至C30例如C1至C8的重复单元,并且X可以包括O、N或S。例如,实施方案的漂白活化剂可以由式II表示:
其中R如上面关于式(I)所述,并且X′可以是包含抗衡离子如金属或有机抗衡离子的吸电子基团(ewg)。在实例中,X′可以选自-COOH、-COONa、-SO3H和-SO3Na。
因此,示例性漂白活化剂可以包括N-或O-酰基化合物、四乙酰甘脲、N-乙酰基N-[4-(三乙基氨甲基)苯甲酰基]己内酰胺氯化物、乙酰氧基苯磺酸钠、苯甲酰氧基苯磺酸钠、月桂酰氧基苯磺酸钠、异壬酰氧基苯磺酸钠、酰化糖衍生物、戊糖、四乙酰乙二胺和壬酰氧基苯磺酸钠(SNOBS或简称NOBS)。在一个实施方案中,漂白活化剂可以是壬酸磺苯酯钠盐(可得自Batesville,AR的FutureFuel ChemicalCompany)。
在一个实例中,漂白活化剂包含壬酰氧基苯磺酸钠,因此与过氧化物的反应形成过氧化壬酸(也称为过壬酸)(PNA),如反应方案2所示:
实施方案的漂白活化剂可存在于牙齿美白组合物中的量的范围为相对于组合物总重量按重量计约0.1%至约25%,诸如约1.5%至约5%,例如约2.5%。因此,可以预先选择设置在第二储存腔室中的第二组分中的漂白活化剂的浓度,和/或可以在从第二储存腔室排出时控制第二组分的体积,从而在通过组合过美白剂和漂白活化剂而形成的牙齿美白组合物中提供上述量的漂白活化剂。
缓冲剂
如上所述,为了实现形成牙齿美白组合物的美白剂与漂白活化剂之间的最大反应,第一组分、第二组分或第一组分和第二组分两者可以单独包含除美白剂和漂白活化剂外的至少一种缓冲剂。在一个实施方案中,第二组分包含缓冲剂。缓冲剂可以以为组合物提供更高pH的任何组合物提供。缓冲剂可以与抗牙结石剂(例如下文针对实施方案的抗牙石剂所述的材料)相同或不同。例如,缓冲剂可以是选自TSPP、TKPP、STPP、磷酸氢二钠和氢氧化钠中的一种或多种。
额外的成分
如先前所述的,在本发明的美白组合物中还可包含许多其他成分,并且这些成分包括例如表面活性剂、调味剂、甜味剂、脱敏剂、抗微生物剂、抗龋剂、抗牙结石剂、抗炎剂、维生素、颜料和着色剂、酶类、防腐剂、研磨剂以及牙垢控制剂。此类额外成分中的任何一种或多种可以包含在含有牙齿美白剂的第一组分和/或含有漂白活化剂的第二组分中。可包含在第一组分中的一种或多种额外的成分可以与第二组分中的一种或多种额外的成分中相同或不同。
可使用任何口腔可接受的表面活性剂,它们大部分是阴离子型、非离子型或两性离子型的。合适的阴离子型表面活性剂包括但不限于C8-20烷基硫酸酯、磺化的C8-20脂肪酸甘油单酯的水溶性盐、肌氨酸盐、牛磺酸盐等。这些和其他种类的例示性实例包括十二烷基硫酸钠、椰油基甘油单酯磺酸钠、月桂基肌氨酸钠、月桂基羟乙基磺酸钠(sodium laurylisoethionate)、月桂醇聚醚羰酸钠(sodium laureth carboxylate)和十二烷基苯磺酸钠。合适的非离子表面活性剂包括但不限于泊洛沙姆、聚氧乙烯失水山梨糖醇酯、脂肪醇聚氧乙烯醚、烷基酚聚氧乙烯醚、叔胺氧化物、叔膦氧化物、二烷基亚砜等。合适的两性型表面活性剂包括但不限于具有阴离子基团(诸如羰酸根、硫酸根、磺酸根、磷酸根或膦酸根)的C8-20脂肪族仲胺和叔胺的衍生物。合适的实例为椰油酰胺基丙基甜菜碱。
在一些实施方案中,一种或多种表面活性剂的存在总量可以为约1.8%至约2%w/w。在一些实施方案中,一种或多种表面活性剂的存在总量可以为约1.9%至约2%w/w。在一些实施方案中,一种或多种表面活性剂的存在总量可以为约2%w/w。
在一些实施方案中,组合物任选包含增稠剂。可以使用任何口腔可接受的增稠剂,其包括但不限于也称为羧乙烯基聚合物的卡波姆、也称为爱尔兰藓并且更具体地为角叉菜胶(ι-卡拉胶)的角叉菜胶、高分子量聚乙二醇(诸如CARBOWAX,可得自Dow ChemicalCompany)、纤维素聚合物(诸如羟乙基纤维素、羧甲基纤维素(CMC)及其盐,例如CMC钠)、天然树胶(诸如刺梧桐胶、黄原胶、阿拉伯树胶和黄蓍胶)、胶体硅酸铝镁以及胶体和/或热解二氧化硅及其混合物。在一些实施方案中,一种或多种任选的增稠剂以约0.1%至约90%w/w的总量存在。在一些实施方案中,一种或多种任选的增稠剂的存在总量为约1%至约50%w/w。在一些实施方案中,一种或多种任选的增稠剂的存在总量为约5%至约35%w/w。
在本文公开的某些实施方案中,牙齿美白组合物还可包含至少一种调味剂。作为实例,至少一种调味剂可以包含在含有牙齿美白剂的第一组分和/或含有漂白活化剂的第二组分中。第一组分中包含的至少一种调味剂可以与第二组分中的相同或不同。
所述至少一种调味剂可例如选自精油以及各种调味醛类、酯类、醇类以及类似材料。精油的实例包括留兰香、胡椒薄荷、冬青、黄樟、三叶草、鼠尾草、桉树、牛至属植物、肉桂、柠檬、酸橙、柚子和橙的油。诸如薄荷醇、香芹酮以及茴香脑等化学品也适用。在这些中,最常采用的是胡椒薄荷、绿薄荷和冬青的油。调味剂可掺入在本文公开的牙齿美白组合物中的浓度的范围为按重量计0.01%至约2%,诸如按重量计约0.1%至约0.6%。
在其中使牙齿美白组合物增甜的实施方案中,至少一种甜味剂可用作至少一种调味剂的替代物或补充物。适合的甜味剂可以是水溶性的并且包括例如糖精钠、环己氨基磺酸钠、木糖醇、紫苏糖(perillartien)、D-色氨酸、阿斯巴甜、二氢查尔酮以及类似物。至少一种甜味剂可存在于牙齿美白组合物中的量的范围为按重量计约0.01%至约1%,诸如约0.3%。
示例性抗微生物剂可包括口腔护理组合物中通常使用的那些,诸如百里香酚;苯甲醇;三氯生;氯己定;亚锡盐,包括铜盐、锌盐和亚锡盐,诸如氧化锌、乳酸锌、柠檬酸锌、硫酸锌、甘氨酸锌、柠檬酸钠锌和焦磷酸亚锡;血根碱提取物;灭滴灵;季铵化合物,诸如氯化十六烷吡啶;双胍类,诸如二葡萄糖酸氯己定、合克替啶(hexetidine)、奥替尼啶、阿立西定;以及卤化双酚化合物,诸如2,2′亚甲基双(4-氯-6-溴苯酚)。
本公开的一些实施方案包括牙齿研磨剂或牙齿研磨药剂的组合。如本文所用,术语“研磨剂”或“研磨药剂”还包括常常称之为“抛光剂”的材料。可使用任何口腔可接受的研磨剂,但是通常应选择研磨剂的类型、细度(粒度)和量使得牙齿釉质在正常使用组合物中不被过度地磨损。合适的研磨剂包括但不限于二氧化硅(呈硅胶、水合二氧化硅或沉淀二氧化硅的形式)、氧化铝、不溶性磷酸盐、碳酸钙、树脂的研磨剂诸如脲醛缩合产物等。
在不溶性磷酸盐中可用作研磨剂的是正磷酸盐、聚偏磷酸盐和焦磷酸盐。示例性实例为正磷酸二钙二水合物、焦磷酸钙、焦磷酸n-钙(n-calciumpyrophosphate)、磷酸三钙、聚偏磷酸钙和不溶性聚偏磷酸钠。
如果存在,则研磨剂的平均粒度通常为约0.1μm至约30μm,例如约1μm至约20μm或约5μm至约15μm。在一些实施方案中,一种或多种研磨剂的存在总量为约0.1%至约40%w/w。在一些实施方案中,研磨剂为焦磷酸钙。在一些实施方案中,焦磷酸钙的存在量为约5%至约50%w/w。
在本公开的多种实施方案中,稳定的美白洁齿剂组合物包含抗牙结石剂。合适的抗牙结石剂非限制地包括磷酸盐和聚磷酸盐(例如焦磷酸盐)、聚氨基丙磺酸(AMPS)、六偏磷酸盐、柠檬酸锌三水合物、多肽、聚烯烃磺酸盐、聚烯烃磷酸盐、二磷酸盐。在一些实施方案中,抗牙结石剂的存在量为约0.1%至约30%w/w。在一些实施方案中,稳定的美白洁齿剂组合物包含抗牙结石剂的混合物。在一些实施方案中,将焦磷酸四钾(TKPP)、焦磷酸四钠(TSPP)和三聚磷酸钠(STPP)用作抗牙结石剂。在一些实施方案中,抗牙结石剂包含约1%至约2%w/w的TSPP和约0%至约7%w/w的STPP。
本发明组合物的另一所需组分为合成的阴离子聚合物聚羧酸盐(SAPP),其充当聚磷酸盐抗牙垢剂的稳定剂并且可帮助阻挡令人不快的或引起疼痛的材料诸如糖到进入牙神经。
示例性抗炎剂可包括口腔护理组合物中通常使用的那些,诸如布洛芬、氟比洛芬、阿司匹林和吲哚美辛。示例性抗龋剂可包括诸如以下的成分:氟化钠、氟化钙、氟化镁和氟化亚锡、氟化胺、单氟磷酸钠以及三偏磷酸钠。示例性维生素可包括诸如维生素C的成分。示例性脱敏剂可包括诸如以下的成分:柠檬酸钾、氯化钾、酒石酸钾、碳酸氢钾、草酸钾、硝酸钾以及锶盐。示例性抗牙结石剂可包括诸如以下的成分:包括单、二、三和四碱金属的焦磷酸盐和焦磷酸铵及三聚磷酸盐。示例性酶可包括葡糖淀粉酶。
一些实施方案提供组合物,其中成分中的至少一种是选自以下各项的氟离子源:氟化亚锡、氟化钠、氟化钾、单氟磷酸钠、氟硅酸钠、氟硅酸铵、氟化胺以及氟化铵。
本文还公开了用于使人或其他动物受试者的口腔中的牙齿表面美白的方法。一种这样的方法包括(a)将如本文所公开的牙齿美白组合物施加到待美白的牙齿表面,每天数分钟;以及(b)重复步骤(a)多天,从而美白牙齿。本文还公开了一种用于美白牙齿表面的方法,该方法包括:向牙齿表面施加包含至少一种美白剂和至少一种漂白活化剂(包含活化酯)的组合物。另一种这样的方法包括(a)将设置在第一储存腔室中的牙齿美白剂与设置在第二储存腔室中的漂白活化剂组合以形成牙齿美白组合物,(b)将如本文公开的牙齿美白组合物施加到待美白的牙齿表面,每天数分钟;以及(c)重复步骤(a)-(b)多天,从而美白牙齿。本文还公开了用于美白牙齿表面的方法,该方法包括:将设置在第一储存腔室中的牙齿美白剂与设置在第二储存腔室中的漂白活化剂组合以形成牙齿美白组合物;向牙齿表面施加包含至少一种美白剂和至少一种漂白活化剂的牙齿美白组合物
本文公开的示例性方法包括使牙齿美白组合物与牙齿表面接触。接触可持续足以满意地实现牙齿美白的持续时间。因此,接触发生足以至少部分美白牙齿的时间段。所述接触的时间段可以范围为约1分钟至约2小时或更长。在某些实施方案中,所述接触持续的时间段范围为约1分钟至约5分钟、约1分钟至约45分钟、约5分钟至约45分钟或约5分钟至约30分钟。
在本文公开的某些实施方案中,可以为基本上非水性的或可以为水性的牙齿美白组合物可在更长的时间段内有效,因为在处理期间它并未在口腔中显著稀释或洗去。牙齿美白组合物可按需要并在需要时随意地通过采用标准口腔卫生程序诸如刷牙或通过用醇类漱口水冲洗来去除。当在适当位置时,组合物可以缓慢的、相对恒定的速率并以足以实现从牙齿去除着色或足以美白牙齿的浓度释放其中含有的试剂。
本文还公开了制备牙齿美白组合物的方法。在一个实例中,实施方案的牙齿美白组合物可通过在合适的容器诸如设置有混合器的不锈钢罐中添加组合物的各成分并进行混合来制备。在牙齿美白组合物的制备中,成分可以按以下顺序添加到混合器中:疏水性聚合物组分,诸如硅酮基压敏性聚合物;过氧化物美白剂;粘附增强剂,包括煅制二氧化硅和矿脂;以及任何希望的调味剂或甜味剂。然后可将所述成分混合以形成均匀分散体/溶液。在另一个实例中,实施方案的牙齿美白组合物可以通过在合适的容器诸如设置有混合器的不锈钢罐中分别添加包含美白剂的第一组分和/或包含漂白剂的第二组分各自的成分并进行混合来制备。在制备包含美白剂的第一组分和/或包含漂白活化剂的第二组分时,可将第一组分和第二组分各自的成分分别加到混合器中:i)对于第一组分:疏水性聚合物组分,如基于硅酮的压敏聚合物;过氧化物美白剂;粘附增强剂,包括煅制二氧化硅和凡士林;和任何所需的调味剂或甜味剂;以及ii)对于第二组分:疏水性聚合物组分,如基于硅酮的压敏聚合物;漂白活化剂;粘附增强剂,包括煅制二氧化硅和凡士林;和任何所需的调味剂或甜味剂。然后可以分别混合第一组分和第二组分各自的成分以形成第一组分和/或第二组分的均匀分散体/溶液。
实施方案的包含至少一种美白剂和至少一种漂白活化剂(例如包含美白剂的第一组分、包含漂白活化剂的第二组分)的牙齿美白组合物可以以可流动的粘性液体分散体如凝胶的形式制备,其中牙齿美白组合物通过将第一组分和第二组分组合而形成。在一个实例中,可以将牙齿美白组合物直接施加到使用者的牙齿上,例如通过用软涂敷器涂抹牙齿或通过牙托施加,包括将第一组分和第二组分置于牙托上然后插入使用者的嘴里。使用者施加后在牙齿上留下组合物涂层。与适当pH下的水性环境(诸如包含美白剂的第一组分的水性组合物中的水或诸如使用者嘴里的唾液)接触使得至少一种美白剂(例如H2O2)解离并与至少一种漂白活化剂反应,从而延长牙齿部位的美白处理。
实施例
实施例1-常规牙齿美白组合物(12%过氧化氢、0%壬酰氧基苯磺酸钠)
通过混合下表1的组分在没有实施方案的任何漂白活化剂的情况下制备了具有12%过氧化氢美白剂的常规牙齿美白组合物。表1中提供了所得的配方,包括按重量%列出的成分列表。
表1
实施例2-制备含有5%漂白活化剂的组合物
为了评估SNOBS增强过氧化氢的美白效力的能力,根据表2的组成制备了包含漂白活化剂壬酰氧基苯磺酸钠的第一种基于SNOBS的组合物。
表2
实施例3-形成包含美白剂和漂白活化剂(6%美白剂、2.5%漂白活化剂)的混合凝胶组合物
通过将等量的12%过氧化氢含水凝胶与5%SNOBS凝胶组合以形成混合后具有6%过氧化氢和2.5%SNOBS浓度的组合物来制备混合凝胶组合物。实施例4-测量过酸浓度与时间的关系。
实施例4-过酸生成
为了对通过混合过氧化物凝胶和SNOBS凝胶产生的过壬酸(PNA)的量进行定量,使用了Karst测定法(Karst等人,Anal.Chem.1997,69,3623-3627)。简而言之,将等份的12%过氧化氢凝胶和5%SNOBS凝胶混合。将20μl混合物以定时的间隔加入磷酸溶液中以停止过酸的生成,结果汇总在表3中。然后使该溶液与过量的甲基对甲苯硫醚(MTS)反应生成甲基对甲苯基亚砜(MTSO)。然后通过HPLC对MTSO定量,并反算PNA的浓度。表4显示了所生成的PNA的浓度。
表3
时间/min | 0 | 2 | 5 | 15 | 30 |
%PNA | 0 | 0.32 | 0.53 | 0.43 | 0.59 |
结果显示通过将SNOBS凝胶与过氧化氢凝胶混合产生了显著量(在30分钟时为0.6%)的壬酸。过酸是比过氧化氢更好的氧化剂,并因此导致改善的美白。
实施例5-体外牛牙釉质试验
将牛牙(安装在丙烯酸树脂上)用研磨牙膏刷洗以达到60与65之间的基线L值。将八颗牛牙分成两组,并使用手持式分光光度计记录基线L*a*b*值。将每颗牙齿置于24孔板中,并在人造唾液中浸泡30分钟。将100μg实施例2的混合凝胶组合物涂布在牛牙表面周围并放置30分钟。然后从牛牙表面擦去凝胶。
收集牛牙的Lab值。这些值用于计算处理后每颗牛牙与基线(W*基线)相比的白度变化。然后将牛牙在人造唾液中浸泡20分钟。该过程重复7次,以模仿每天使用一次持续一周。这里根据W*值报告计算出的白度变化,W*值是相对于纯白色的总体颜色变化的量度。应该注意的是,ΔW*值越负,牙齿颜色越接近白色,其中W*被确定为:
W*=((a*-0)2+(b*-0)2+(L*-100)2)1/2并且
ΔW*=W*处理后-W*基线。
使用具有2.5重量%壬酰氧基苯磺酸钠(SNOBS)的样品与具有0重量%SNOBS的样品相比测试了美白功效。在牛牙上进行7次处理后,获得了美白功效的显著差异。与仅含过氧化氢的组合物相比,含有2.5%SNOBS的改良牙齿美白组合物以更快的速率实现了优异的美白作用。如表4所示,使用6%HP的七次处理具有与2.5%SNOBS配方存在下大约3次处理等效的结果。
表4总结了用2.5重量%的含SNOBS的组合物糊剂处理的牛牙样品相对于具有6%过氧化氢的对照美白糊剂(0%SNOBS)在7次处理过程中增强的美白(ΔW*)效果。
表4
实施例6-SNOBS稳定性
根据基于表5中所示成分的组成,将SNOBS包含在无水配方中。
表5
成分 | % |
非离子型表面活性剂 | 33 |
增稠剂 | 40 |
湿润剂 | 10 |
研磨剂(煅制二氧化硅) | 5 |
TSPP | 2 |
SNOBS | 10 |
将表5的组合物分别在40℃和室温下老化8周和13周。通过HPLC对剩余的SNOBS的百分比进行定量。表6中的结果表明,在室温和40℃下老化之后,组合物中剩余的足够的SNOBS能有效用作牙齿美白组合物中过氧化物组分的增效剂。
表6
时间/老化温度 | %SNOBS | SNOBS的损失% |
初始 | 9.6 | - |
4周/40℃ | 936 | 3.1 |
8周/40℃ | 8.99 | 6.4 |
13周/室温(RT) | 9.21 | 4.06 |
实施例7-常规牙齿美白组合物(0%壬酰氧基苯磺酸钠)
通过混合下表1的组分在没有任何漂白活化剂的情况下制备了具有1%过氧化氢美白剂的常规牙齿美白牙膏。表7中提供了所得的配方,包括按重量%列出的成分列表。
表7
实施例8-具有漂白活化剂的牙齿美白牙膏(1%美白剂、2.5%漂白活化剂)
通过降低丙二醇的量,将漂白活化剂壬酰氧基苯磺酸钠(SNOBS)加入表1的2.5%下的市售(1%过氧化氢)牙齿美白配方中,以得到表8中列出的配方。
表8
成分 | 重量% |
湿润剂 | 41.66 |
研磨剂系统II | 18.38 |
增稠剂 | 23.38 |
与过氧化氢络合的交联PVP | 5.500 |
微量组分(着色剂、香料、风味剂) | 适量 |
焦磷酸四钠-细FCC | 2.000 |
月桂基硫酸钠粉末 | 2.000 |
酸式焦磷酸钠 | 0.900 |
单氟磷酸钠-USP | 0.760 |
丁基化羟基甲苯,FCC级 | 0.030 |
壬酸磺苯酯钠盐(1∶1) | 2.500 |
总计 | 100.000 |
实施例9-体外牛牙釉质试验
将牛牙(安装在丙烯酸树脂上)用研磨牙膏刷洗以达到60与65之间的基线L值。将牛牙分成3组,并使用手持式分光光度计记录基线L*a*b*值。将每组牛牙置于指定的玻璃烧杯中,以分别用含有0%(常规牙齿美白配方)、2.5%(表8的牙齿美白配方)和如表9所示的5%SNOBS(向表8的配方进一步添加漂白活化剂同时减少丙二醇的量)的牙膏进行后续处理。
表9
成分 | 重量% |
湿润剂 | 39.16 |
研磨剂 | 18.38 |
增稠剂 | 23.38 |
与过氧化氢络合的交联PVP | 5.50 |
微量组分(着色剂、香料、风味剂) | 适量 |
焦磷酸四钠-细FCC | 2.00 |
月桂基硫酸钠粉末 | 2.00 |
酸式焦磷酸钠 | 0.90 |
单氟磷酸钠-USP | 0.76 |
丁基化羟基甲苯,FCC级 | 0.03 |
壬酸磺苯酯钠盐(1∶1) | 5.00 |
总计 | 100.00 |
通过与7ml人造唾液混合分别制备了含有7g具有0重量%、2.5重量%和5重量%SNOBS漂白活化剂的Optic White牙膏的样品。将样品迅速混合并倒入装有上述牛牙的指定烧杯中。将烧杯置于摇动器中并摇动2分钟。然后用水冲洗每个烧杯的牛牙,直到牙膏被洗掉。对于每个烧杯,重复振动和冲洗步骤14次以模拟使用一周牙膏(即14次处理)。在第7次和第14次处理后收集牛牙的L a b值(W*处理)。这些值用于计算处理后每颗牛牙与基线(W*基线)相比的白度变化。这里根据W*值报告计算出的白度变化,W*值是相对于纯白色的总体颜色变化的量度。应该注意的是,ΔW*值越负,牙齿颜色越接近白色,其中W*被确定为:
W*=((a*-0)2+(b*-0)2+(L*-100)2)1/2并且
ΔW*=W*处理后-W*基线。
使用将2.5重量%壬酰氧基苯磺酸钠(SNOBS)加到常规的商业牙齿美白牙膏(1%过氧化氢)中的样品来测试美白功效。在牛牙上进行14次的两分钟处理后,获得了美白效果的显著差异。如表10所示,含有2.5%SNOBS的改良的牙齿美白牙膏显示出,与不含任何SNOBS的商业牙齿美白牙膏相比,美白增加64%。总的来说,表10中的数据显示SNOBS是增强美白的大有希望的候选物。
表10总结了用5%和2.5重量%的含SNOBS的美白糊剂处理的牛牙样品相对于具有0%SNOBS的对照美白糊剂增强的美白(ΔW*)效果。
表10
7次处理 | 14次处理 | |
0%SNOBS | -1.14 | -2.38 |
2.5%SNOBS | -2.66 | -3.91 |
5%SNOBS | -2.31 | -4.37 |
实施例10-在60℃老化中Optic White(OW)与2.5%SNOBS牙膏的稳定性
将数批市售牙齿美白系统(Optic White 1%HP,可得自Colgate-Palmolive)和包含2.5%壬酰氧基苯磺酸钠(SNOBS)漂白活化剂的实施方案的牙齿美白系统置于60℃烘箱中。起初、1周后和2周后测量过氧化氢含量。
通过使牙膏中的过氧化氢与酸性介质中的碘化钾反应释放碘来测定每个样品中剩余的过氧化氢的量。然后通过手动滴定用标准硫代硫酸钠对释放的碘进行滴定。如下用等式1计算过氧化氢百分比:
过氧化氢%=[(A x N x C)/(D)]x100/样品体积(mL),
其中A是硫代硫酸钠的体积(以mL计),N是硫代硫酸钠溶液的当量浓度,C是氧化剂的毫当量重量(例如标准硫代硫酸钠滴定中过氧化氢的毫当量重量为0.01701),而D是样品体积(以mL计)。
1周后,不含漂白活化剂的对比性Optic White(OW)配方显示过氧化物含量略有下降(从最初的约1.0%到第1周的约0.91%),在第2周几乎没有后续变化(从第1周的约0.91%到第2周的约0.905%)。类似地,具有2.5%SNOBS的示例性OW配方显示过氧化物量的可接受的降低(从最初的约0.950%到第1周的约0.800%),以及在第2周可接受的后续变化(从第1周的约0.800%到第2周的约0.730%)。该60℃老化研究表明,即使在实施方案的牙齿美白配方中存在2.5%SNOBS的情况下,过氧化氢仍可保持在可接受的水平。
Claims (6)
1.一种牙齿美白组合物,包含:
至少一种美白剂,其中所述至少一种美白剂是聚乙烯吡咯烷酮-过氧化氢交联复合物;
至少一种漂白活化剂,其中所述至少一种漂白活化剂选自四乙酰甘脲、N-乙酰基N-[4-(三乙基氨甲基)苯甲酰基]己内酰胺氯化物、乙酰氧基苯磺酸钠、苯甲酰氧基苯磺酸钠、月桂酰氧基苯磺酸钠、异壬酰氧基苯磺酸钠、酰化糖衍生物、戊糖和壬酰氧基苯磺酸钠;
至少一种研磨剂,其中所述至少一种研磨剂选自正磷酸二钙二水合物、焦磷酸钙、焦磷酸n-钙、磷酸三钙、聚偏磷酸钙和不溶性聚偏磷酸钠及其混合物;
至少一种抗牙结石剂,其中所述至少一种抗牙结石剂选自焦磷酸四钾(TKPP)、焦磷酸四钠(TSPP)、三聚磷酸钠(STPP)、聚氨基丙磺酸(AMPS)、六偏磷酸盐、柠檬酸锌三水合物、多肽、聚烯烃磺酸盐、聚烯烃磷酸盐、二磷酸盐、及其混合物;
增稠剂;并且
其中所述组合物的pH大于7.5且小于或等于9。
2.根据权利要求1所述的组合物,其中所述至少一种漂白活化剂以大于所述至少一种美白剂的量的量存在。
3.根据权利要求1所述的组合物,其中所述至少一种美白剂以大于0重量%且小于10%的量存在。
4.根据权利要求1所述的组合物,其中所述至少一种美白剂以大于2重量%且小于6重量%的量存在。
5.根据权利要求4所述的组合物,其中所述组合物无水。
6.根据权利要求5所述的组合物,其中所述组合物是凝胶。
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2015/066282 WO2017105455A1 (en) | 2015-12-17 | 2015-12-17 | Hydrogen peroxide booster system for enhanced teeth whitening |
Publications (2)
Publication Number | Publication Date |
---|---|
CN108430586A CN108430586A (zh) | 2018-08-21 |
CN108430586B true CN108430586B (zh) | 2021-07-23 |
Family
ID=55077656
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201580085351.XA Active CN108430586B (zh) | 2015-12-17 | 2015-12-17 | 用于增强的牙齿美白的过氧化氢增效剂系统 |
Country Status (11)
Country | Link |
---|---|
US (1) | US20180369087A1 (zh) |
EP (1) | EP3383503B1 (zh) |
CN (1) | CN108430586B (zh) |
AU (1) | AU2015417676B2 (zh) |
BR (1) | BR112018011560B1 (zh) |
CA (1) | CA3000809A1 (zh) |
IL (1) | IL259553A (zh) |
MX (1) | MX2018007049A (zh) |
RU (1) | RU2018122117A (zh) |
WO (1) | WO2017105455A1 (zh) |
ZA (1) | ZA201803099B (zh) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108128797B (zh) * | 2017-12-29 | 2019-10-08 | 王崇 | 一种插层水滑石及其制备方法和牙齿美白凝胶 |
US20230129930A1 (en) * | 2021-10-22 | 2023-04-27 | Zest Ip Holdings, Llc | Teeth whitening compositions, kits, and systems |
CN115919685B (zh) * | 2022-11-18 | 2024-03-22 | 杭州纳美智康科技有限公司 | 双管美白牙膏及其制备方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005089360A (ja) * | 2003-09-17 | 2005-04-07 | Sun Medical Co Ltd | 歯牙用漂白剤組成物 |
CN1764433A (zh) * | 2003-02-05 | 2006-04-26 | 考里安国际公司 | 用于牙齿增白的水凝胶组合物 |
CN102429829A (zh) * | 2011-12-10 | 2012-05-02 | 江西炫尼诗科技有限公司 | 牙科诊室用强效牙齿漂白凝胶 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030228264A1 (en) * | 2002-06-06 | 2003-12-11 | Perna Salvatore F. | Dissolvable teeth whitening apparatus |
DE10260903A1 (de) * | 2002-12-20 | 2004-07-08 | Henkel Kgaa | Neue Perhydrolasen |
US20060062744A1 (en) * | 2004-09-17 | 2006-03-23 | Jeffrey Lokken | Composition for whitening teeth and method of making the same |
CA2822648A1 (en) * | 2004-12-21 | 2006-06-29 | Corium International, Inc. | Sustained release tooth whitening formulations and systems |
US20070071696A1 (en) * | 2005-09-27 | 2007-03-29 | Colgate-Palmolive Company | Dual phase whitening dentifrice |
US20090311198A1 (en) * | 2006-03-03 | 2009-12-17 | Concar Edward M | Perhydrolase for Tooth Whitening |
MX354223B (es) * | 2011-12-19 | 2018-02-19 | Colgate Palmolive Co | Sistema que provee una reaccion catalizada por perhidrolasas. |
-
2015
- 2015-12-17 AU AU2015417676A patent/AU2015417676B2/en active Active
- 2015-12-17 BR BR112018011560-6A patent/BR112018011560B1/pt active IP Right Grant
- 2015-12-17 EP EP15821225.8A patent/EP3383503B1/en active Active
- 2015-12-17 MX MX2018007049A patent/MX2018007049A/es unknown
- 2015-12-17 CN CN201580085351.XA patent/CN108430586B/zh active Active
- 2015-12-17 CA CA3000809A patent/CA3000809A1/en not_active Abandoned
- 2015-12-17 US US16/062,134 patent/US20180369087A1/en not_active Abandoned
- 2015-12-17 RU RU2018122117A patent/RU2018122117A/ru unknown
- 2015-12-17 WO PCT/US2015/066282 patent/WO2017105455A1/en active Application Filing
-
2018
- 2018-05-11 ZA ZA2018/03099A patent/ZA201803099B/en unknown
- 2018-05-23 IL IL259553A patent/IL259553A/en unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1764433A (zh) * | 2003-02-05 | 2006-04-26 | 考里安国际公司 | 用于牙齿增白的水凝胶组合物 |
JP2005089360A (ja) * | 2003-09-17 | 2005-04-07 | Sun Medical Co Ltd | 歯牙用漂白剤組成物 |
CN102429829A (zh) * | 2011-12-10 | 2012-05-02 | 江西炫尼诗科技有限公司 | 牙科诊室用强效牙齿漂白凝胶 |
Also Published As
Publication number | Publication date |
---|---|
AU2015417676B2 (en) | 2019-07-25 |
EP3383503B1 (en) | 2022-07-27 |
CA3000809A1 (en) | 2017-06-22 |
CN108430586A (zh) | 2018-08-21 |
RU2018122117A (ru) | 2020-01-17 |
EP3383503A1 (en) | 2018-10-10 |
ZA201803099B (en) | 2022-12-21 |
RU2018122117A3 (zh) | 2020-01-17 |
US20180369087A1 (en) | 2018-12-27 |
BR112018011560A2 (pt) | 2018-11-27 |
IL259553A (en) | 2018-07-31 |
AU2015417676A1 (en) | 2018-05-31 |
WO2017105455A1 (en) | 2017-06-22 |
BR112018011560B1 (pt) | 2021-06-08 |
MX2018007049A (es) | 2018-08-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US9498425B2 (en) | Oral care compositions | |
TW201534339A (zh) | 美白口腔保健組成物 | |
CN106572951B (zh) | 牙齿色斑去除和预防 | |
US9974634B2 (en) | Methods for whitening teeth | |
CN108430586B (zh) | 用于增强的牙齿美白的过氧化氢增效剂系统 | |
EP3383357B1 (en) | Hydrogen peroxide booster system for enhanced teeth whitening | |
CA3080470A1 (en) | Whitening compositions and methods for increasing stability of the same | |
US10925818B2 (en) | Oral care compositions and methods for increasing stability of the same | |
AU2017441067B2 (en) | Oral care compositions and methods for increasing stability of the same | |
KR20150087845A (ko) | 구강 위생 미백 조성물 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant |