CN108430491A - 肽 - Google Patents

肽 Download PDF

Info

Publication number
CN108430491A
CN108430491A CN201680074733.7A CN201680074733A CN108430491A CN 108430491 A CN108430491 A CN 108430491A CN 201680074733 A CN201680074733 A CN 201680074733A CN 108430491 A CN108430491 A CN 108430491A
Authority
CN
China
Prior art keywords
peptide
amino acid
cells
seq
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201680074733.7A
Other languages
English (en)
Chinese (zh)
Inventor
R·摩根
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hox Treats Co Ltd
Original Assignee
Hox Treats Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hox Treats Co Ltd filed Critical Hox Treats Co Ltd
Publication of CN108430491A publication Critical patent/CN108430491A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201680074733.7A 2015-10-21 2016-10-20 肽 Pending CN108430491A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1518700.8 2015-10-21
GB1518700.8A GB2543550A (en) 2015-10-21 2015-10-21 Peptides
PCT/GB2016/053282 WO2017068353A1 (en) 2015-10-21 2016-10-20 Peptides

Publications (1)

Publication Number Publication Date
CN108430491A true CN108430491A (zh) 2018-08-21

Family

ID=55131441

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680074733.7A Pending CN108430491A (zh) 2015-10-21 2016-10-20 肽

Country Status (13)

Country Link
US (1) US10494412B2 (https=)
EP (2) EP3364992B1 (https=)
JP (1) JP2018533570A (https=)
KR (1) KR20180080217A (https=)
CN (1) CN108430491A (https=)
AU (1) AU2016341494A1 (https=)
BR (1) BR112018008136A2 (https=)
CA (1) CA3002739A1 (https=)
EA (1) EA201890900A1 (https=)
ES (1) ES2775740T3 (https=)
GB (1) GB2543550A (https=)
MX (1) MX2018004930A (https=)
WO (1) WO2017068353A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN121287874A (zh) * 2025-12-12 2026-01-09 广州飞来爱生命科技有限公司 一种治疗前列腺疾病的间充质干细胞组合物及其制备方法和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090030178A1 (en) * 2006-08-02 2009-01-29 Phoenix Pharmaceuticals, Inc. Cell permeable bioactive peptide conjugates
CN102089320A (zh) * 2008-01-24 2011-06-08 埃斯佩兰斯医药公司 溶解结构域融合构建体及其制备和使用方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8607683D0 (en) 1986-03-27 1986-04-30 Ici Plc Anti-tumor agents
US5595756A (en) * 1993-12-22 1997-01-21 Inex Pharmaceuticals Corporation Liposomal compositions for enhanced retention of bioactive agents
AU1681095A (en) * 1994-01-14 1995-08-01 Matthias Rath Hydrophilic signal oligopeptides and methods of therapeutic use
US5608082A (en) 1994-07-28 1997-03-04 Agouron Pharmaceuticals, Inc. Compounds useful as antiproliferative agents and GARFT inhibitors
UA60365C2 (uk) 1998-06-04 2003-10-15 Пфайзер Продактс Інк. Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця
US6682736B1 (en) 1998-12-23 2004-01-27 Abgenix, Inc. Human monoclonal antibodies to CTLA-4
TWI262914B (en) 1999-07-02 2006-10-01 Agouron Pharma Compounds and pharmaceutical compositions for inhibiting protein kinases
UA75055C2 (uk) 1999-11-30 2006-03-15 Пфайзер Продактс Інк. Похідні бензоімідазолу, що використовуються як антипроліферативний засіб, фармацевтична композиція на їх основі
SI1255752T1 (sl) 2000-02-15 2007-12-31 Pharmacia & Upjohn Co Llc S pirolom substituirani zaviralci 2-indolinon protein kinaza
BRPI0116728B1 (pt) 2001-01-05 2018-10-30 Pfizer Inc. anticorpos para receptor de fator de crescimento i semelhante à insulina
AR039067A1 (es) 2001-11-09 2005-02-09 Pfizer Prod Inc Anticuerpos para cd40
WO2004078163A2 (en) 2003-02-28 2004-09-16 Transform Pharmaceuticals, Inc. Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen
PA8580301A1 (es) 2002-08-28 2005-05-24 Pfizer Prod Inc Nuevos derivados de benzoimidazol utiles como agentes antiproliferativos
GB0229151D0 (en) * 2002-12-13 2003-01-15 St Georges Entpr Ltd Product and method
US7259266B2 (en) 2003-03-31 2007-08-21 Pharmacia Corporation Benzopyran compounds useful for treating inflammatory conditions
US20050148627A1 (en) 2003-03-31 2005-07-07 Jeffery Carter Benzopyran compounds for use in the treatment and prevention of inflammation related conditions
WO2007000601A2 (en) * 2005-06-29 2007-01-04 St Georges Enterprises Limited Gene regulation
JP6943759B2 (ja) 2017-12-28 2021-10-06 株式会社東海理化電機製作所 シフト装置

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090030178A1 (en) * 2006-08-02 2009-01-29 Phoenix Pharmaceuticals, Inc. Cell permeable bioactive peptide conjugates
CN102089320A (zh) * 2008-01-24 2011-06-08 埃斯佩兰斯医药公司 溶解结构域融合构建体及其制备和使用方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ROBERTO BESSALLE等: "Structure-Function Studies of Amphiphilic Antibacterial Peptides", 《JOURNAL OF MEDICINAL CHEMISTRY》 *
杨蕾等: "PBX1在肿瘤中的研究进展", 《实用肿瘤杂志》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN121287874A (zh) * 2025-12-12 2026-01-09 广州飞来爱生命科技有限公司 一种治疗前列腺疾病的间充质干细胞组合物及其制备方法和应用

Also Published As

Publication number Publication date
EP3364992A1 (en) 2018-08-29
GB201518700D0 (en) 2015-12-02
US10494412B2 (en) 2019-12-03
CA3002739A1 (en) 2017-04-27
GB2543550A (en) 2017-04-26
KR20180080217A (ko) 2018-07-11
EP3364992B1 (en) 2019-12-04
AU2016341494A1 (en) 2018-05-24
ES2775740T8 (es) 2020-08-06
WO2017068353A1 (en) 2017-04-27
US20180282384A1 (en) 2018-10-04
ES2775740T3 (es) 2020-07-28
MX2018004930A (es) 2018-11-09
EP3610883A1 (en) 2020-02-19
JP2018533570A (ja) 2018-11-15
EA201890900A1 (ru) 2018-10-31
BR112018008136A2 (pt) 2018-11-06

Similar Documents

Publication Publication Date Title
AU2005286190A1 (en) Therapeutic combinations comprising poly(ADP-ribose) polymerases inhibitor
AU2016370846B2 (en) Combinations for the treatment of cancer
MXPA06014021A (es) Procedimiento para tratar crecimiento celular anormal.
WO2010033771A2 (en) Modulators of hsp70/dnak function and methods of use thereof
JP2022520997A (ja) イミプリドンを使用する方法
Impicciatore et al. Nutlins and ionizing radiation in cancer therapy
JP2019524851A (ja) がんを治療するための組み合わせ
MX2008012791A (es) Terapia de combinacion de (2r,z)-2-amino-2-ciclohexil-n-(5-(1-meti l-1h-pirazol-4-il)-1-oxo-2,6-dihidro-1h-[1,2]diazepinos[4,5,6-cd[ indol-8-il)acetamida.
EP3364992B1 (en) Peptides
WO2012117224A1 (en) Dipyridinium derivatives
US20190256502A1 (en) Organic compounds
CN120365366A (zh) 一组广谱杀死肿瘤细胞并引起肿瘤细胞免疫原性死亡的多肽及其制备方法、给药系统和应用
CN120349384A (zh) 一种能引起肿瘤细胞免疫原性死亡的多肽及其制备方法、给药系统和应用
CN120349383A (zh) 能引起肿瘤细胞免疫原性死亡，广谱杀死肿瘤细胞的多肽及其制备方法、给药系统和应用
CN120365375A (zh) 有效杀死肿瘤细胞并引起肿瘤细胞免疫原性死亡的多肽及其制备方法、给药系统和应用
CN101384264B (zh) 含有聚（adp-核糖）聚合酶抑制剂的治疗组合物
Hay et al. 258 POSTER Tricyclic triazin 1, 4-dioxides: a new class of hypoxia-selective cytotoxins with improved extravascular transport compared to tirapazamine
WO2020160221A2 (en) Macrocyclic peptides for targeted inhibition of autophagy
AU2011253816A1 (en) Therapeutic combinations comprising poly(ADP-ribose) polymerases inhibitor
HK1127956A (en) Therapeutic combinations comprising poly(adp-ribose) polymerases inhibitor

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20180821

WD01 Invention patent application deemed withdrawn after publication