CN108411173A - A kind of bio-medical Mg-Sn-Zn-Sr magnesium alloys and preparation method thereof - Google Patents

A kind of bio-medical Mg-Sn-Zn-Sr magnesium alloys and preparation method thereof Download PDF

Info

Publication number
CN108411173A
CN108411173A CN201810272939.1A CN201810272939A CN108411173A CN 108411173 A CN108411173 A CN 108411173A CN 201810272939 A CN201810272939 A CN 201810272939A CN 108411173 A CN108411173 A CN 108411173A
Authority
CN
China
Prior art keywords
magnesium
magnesium alloy
bio
medical
pure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201810272939.1A
Other languages
Chinese (zh)
Inventor
张扬
宋雷鹏
陈晓阳
卢雅琳
丛孟启
李小平
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jiangsu University of Technology
Original Assignee
Jiangsu University of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jiangsu University of Technology filed Critical Jiangsu University of Technology
Priority to CN201810272939.1A priority Critical patent/CN108411173A/en
Publication of CN108411173A publication Critical patent/CN108411173A/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22C—ALLOYS
    • C22C23/00—Alloys based on magnesium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/04—Metals or alloys
    • A61L27/047—Other specific metals or alloys not covered by A61L27/042 - A61L27/045 or A61L27/06
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22C—ALLOYS
    • C22C1/00—Making non-ferrous alloys
    • C22C1/02—Making non-ferrous alloys by melting
    • C22C1/03—Making non-ferrous alloys by melting using master alloys
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22F—CHANGING THE PHYSICAL STRUCTURE OF NON-FERROUS METALS AND NON-FERROUS ALLOYS
    • C22F1/00—Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working
    • C22F1/002—Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working by rapid cooling or quenching; cooling agents used therefor
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22F—CHANGING THE PHYSICAL STRUCTURE OF NON-FERROUS METALS AND NON-FERROUS ALLOYS
    • C22F1/00—Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working
    • C22F1/06—Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working of magnesium or alloys based thereon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Materials Engineering (AREA)
  • Mechanical Engineering (AREA)
  • Metallurgy (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Thermal Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Materials For Medical Uses (AREA)

Abstract

The invention belongs to technical field of magnesium alloy material, and in particular to a kind of bio-medical Mg Sn Zn Sr magnesium alloys and preparation method thereof, the magnesium alloy includes following weight percent composition：The total amount of Sn 0.5 1.5%, Zn 0.3 0.7%, Sr 0.05 0.15%, impurity element S i, Fe, Cu and Ni are less than 0.02%, surplus Mg.Its technique is first to carry out mixed smelting to each ingredient, then carries out solution heat treatment, is finally plastically deformed.Magnesium alloy of the present invention selects a variety of the essential trace elements of the human bodys, while controlling alloying element total amount, and material non-toxic has good corrosion resistance and high-strength tenacity, can human body degradation.

Description

A kind of bio-medical Mg-Sn-Zn-Sr magnesium alloys and preparation method thereof
Technical field
The invention belongs to technical field of magnesium alloy material, and in particular to a kind of bio-medical Mg-Sn-Zn-Sr magnesium alloys and Preparation method.
Background technology
The metals such as traditional stainless steel, titanium alloy biological implantation material also exposes while obtaining extensive clinical application Go out some drawbacks：(1) stainless steel, titanium alloy etc materials and skeleton have a long way to go on elasticity modulus, generate and answer after implantation Power occlusion effect influences knitting process or leads to osteoporosis, or even causes secondary fracture；(2) although stainless steel, titanium alloy The chemical property of equal materials is stablized relatively, but may still release part harmful ion during being chronically implanted, and there is initiation Inflammation, the risk of allergy；(3) due to stainless steel, titanium alloy etc materials non-degradable in vivo, tissue functional rehabilitation it After need to take out by second operation, increase the pain, second operation risk and medical treatment cost of patient.With traditional stainless steel, The metal materials such as titanium alloy are compared, and magnesium alloy has a series of unique advantages as biological implantation material.In recent years, magnesium closes Golden material has become the research hotspot in biological implantation material field, and domestic and foreign scholars have carried out largely around Biological magnesium alloy material Research, but there are still a certain distance, major obstacle to be between clinical application at present：(1) alloy in the magnesium alloy of part There are genotoxic potentials for element；(2) in fluid environment, the degradation rate of magnesium alloy is too fast, is easy to happen serious local corrosion. Rational composition design and processing method selection, are exploitation new bio magnesium alloy materials, improve magnesium alloy in fluid environment Corrosion resistance, while improving the potential approach of its mechanical property.
In recent years, magnesium tin (Mg-Sn) is that alloy is used as a kind of potential Biological magnesium alloy material, gradually causes to learn both at home and abroad The attention of person.Sn belongs to the essential trace elements of the human body, and zoopery proves that Sn element toxicity is very low, meets biocompatibility It is required that.From the point of view of mechanical property angle, addition Sn elements can improve the intensity and plasticity of magnesium alloy.Zhen et al. is by Mg- 3Sn-0.5Mn (wt.%) alloys and the WE43 alloys of most study in current Biological magnesium alloy compare, and find the corrosion of the alloy Rate is less than WE43 alloys, and corrodes more uniformly (Zhen Z, Xi T, Zheng Y, et al.In vitro study on Mg-Sn-Mn alloy as biodegradable metals[J].Journal of Materials Science& Technology,2014,30(7):675-685.).J.Kub á sek et al. compared different-alloy constituent content Mg-Sn, Mg-Ga and Mg-In three classes cast bianry alloy, are examined from many-sided synthesis such as corrosion rate, cytotoxicity, mechanical property and cost Consider, it is believed that Mg-1Sn alloys are more suitable Biological magnesium alloy material (Kub á sek J, Vojt ě ch D, Lipov J, et al.Structure,mechaniSrl properties,corrosion behavior and cytotoxicity of Biodegradable Mg-X (X=Sn, Ga, In) alloys [J] .Materials Science and Engineering:C, 2013,33(4):2421-2432.)。
Invention content
Invention broadly provides a kind of bio-medical Mg-Sn-Zn-Sr magnesium alloys and preparation method thereof, the alloy materials Nontoxicity has good corrosion resistance and high-strength tenacity, can human body degradation.Its technical solution is as follows：
A kind of bio-medical Mg-Sn-Zn-Sr magnesium alloys comprising following weight percent composition：Sn 0.5-1.5%, The total amount of Zn 0.3-0.7%, Sr 0.05-0.15%, impurity element S i, Fe, Cu and Ni are less than 0.02%, surplus Mg.
A kind of preparation method of above-mentioned bio-medical Mg-Sn-Zn-Sr magnesium alloys, includes the following steps：
(1) it is carried out under gas shield using pure magnesium ingot, pure tin ingot, pure zinc ingot and Mg-Sr intermediate alloys according to formula ratio Melting obtains Mg-Sn-Zn-Sr systems magnesium alloy ingot；
(2) solution heat treatment being carried out to Mg-Sn-Zn-Sr systems magnesium alloy ingot, solid solution temperature is 350-450 DEG C, when Between be 12-24h, water quenching is to room temperature after solid solution；
(3) the Mg-Sn-Zn-Sr systems magnesium alloy after solution heat treatment is plastically deformed, using mixing yoghurt skill Art, stirring-head rotating speed are 400-1600r/min, feed speed 40-200mm/min.
Preferably, protective gas is SF in step (1)6With CO2Mixed gas.
Preferably, method of smelting is in step (1)：First pure magnesium is melted, pure tin is added when temperature rises to 720-740 DEG C With pure zinc, 8-12min is stirred after its fusing；Mg-10Sr intermediate alloys are then added, continuing stirring 8-12min keeps alloy first Element is evenly distributed, and is cooled to 710-720 DEG C of heat preservation 10min, removes surface scum, be poured into and be preheated to 180-220 DEG C of metal In pattern tool.
Each alloys producing is as follows in magnesium alloy：
Sn is one of the essential trace elements of the human body, and toxicity is minimum, and the adult of weight 70kg need to take in about 7.0mg daily Sn.Sn can improve the temperature-room type plasticity and intensity of magnesium alloy.
Zn is one of the essential trace elements of the human body, and participation forms follicle-stimulating hormone (FSH) and leuteinization hormone (LH), simultaneously The synthesis for participating in being formed DNA component zinc finger proteins, participates in the formation of a variety of enzymes.Zn can also promote the tensile strength of magnesium alloy And yield strength.
Sr also contributes to improve bone strength and bone mineral density, can be used for treating sclerotin shrinkage porosite disease.In addition, Sr also by It proves that osteoclast activity can be reduced and promotes the breeding of osteoblast, the suction of sclerotin is reduced while stimulating New bone formation It receives.Sr has strong Grain Refinement Effect in magnesium alloy crowd.
Plastic deformation can induce the recrystallization of magnesium alloy, and crystal grain thinning realizes refined crystalline strengthening, and crystal grain refinement is to improving magnesium The corrosion resistance of alloy also has very great help.
Using the above scheme, the present invention has the following advantages：
(1) a kind of degradable biological medical Mg- having both nontoxicity, good corrosion resistance and high-strength tenacity of the present invention Sn-Zn-Sr systems magnesium alloy and preparation method thereof, using nontoxic composition design, involved Sn, Zn and Sr element is all human body Required trace element；
(2) Mg-Sn-Zn-Sr systems of the present invention magnesium alloy, is designed using multicomponent microalloying, can be better The effect of each alloying element in the alloy is played, the corrosion resistance of alloy is improved, and improves its mechanical property；
(3) Mg-Sn-Zn-Sr systems of the present invention magnesium alloy controls alloying element total amount, cast, solid solution and plasticity Single-phase magnesium alloy is obtained after deformation, substantially eliminates the second phase, significantly inhibits the generation of galvanic corrosion, improves the corrosion resistant of alloy Corrosion energy, while ensuring can be degradable after the implantation organism of alloy is interior；
(4) Mg-Sn-Zn-Sr systems of the present invention magnesium alloy, after plastic deformation, crystal grain is refined, alloy it is resistance to Corrosive nature and mechanical property are improved.
Specific implementation mode
Experimental method in following embodiment is conventional method unless otherwise required, involved experiment reagent and material Material is conventional biochemical reagent and material unless otherwise required.
Embodiment 1
Magnesium alloy described in the present embodiment is made of Mg, Sn, Zn and Sr element, and each component mass percentage is：0.5% The total amount of Sn, 0.3%Zn, 0.15%Sr, impurity element S i, Fe, Cu and Ni are less than 0.02%, surplus Mg.
The preparation method of the alloy includes three melting, solution heat treatment and plastic deformation technique processes.
Wherein, preceding smelting technology process is in SF6And CO2It is carried out under the conditions of mixed gas protected, steps are as follows：It will be pure Magnesium melts in crucible electrical resistance furnace, and pure tin and pure zinc are added when temperature rises to 730 DEG C, and 10min is stirred after its fusing；Then Mg-10Sr intermediate alloys are added, continuing stirring 10min keeps alloying elements distribution uniform.720 DEG C of heat preservation 10min are cooled to, fishing is gone Surface scum is poured into and is preheated in 200 DEG C of metal type dies.
Subsequent solution heat treatment process is：The alloy cast ingot that melting is obtained is kept the temperature for 24 hours at 350 DEG C, subsequent water It quenches to room temperature.
Subsequent plastic deformation process process is：Mg-Sn-Zn-Sr alloys after solution treatment are plastically deformed, are adopted With mixing yoghurt technology, stirring-head rotating speed is 400r/min, feed speed 200mm/min.
The room temperature tensile intensity of acquired alloy is 257MPa, elongation percentage 21%.
Embodiment 2
Magnesium alloy described in the present embodiment is made of Mg, Sn, Zn and Sr element, and each component mass percentage is：1.0% The total amount of Sn, 0.5%Zn, 0.1%Sr, impurity element S i, Fe, Cu and Ni are less than 0.02%, surplus Mg.
The preparation method of the alloy includes three melting, solution heat treatment and plastic deformation technique processes.
Wherein, preceding smelting technology process is in SF6And CO2It is carried out under the conditions of mixed gas protected, steps are as follows：It will be pure Magnesium melts in crucible electrical resistance furnace, and pure tin and pure zinc are added when temperature rises to 730 DEG C, and 10min is stirred after its fusing；Then Mg-10Sr intermediate alloys are added, continuing stirring 10min keeps alloying elements distribution uniform.720 DEG C of heat preservation 10min are cooled to, fishing is gone Surface scum is poured into and is preheated in 200 DEG C of metal type dies.
Subsequent solution heat treatment process is：The alloy cast ingot that melting is obtained keeps the temperature 16h, subsequent water at 400 DEG C It quenches to room temperature.
Subsequent plastic deformation process process is：Mg-Sn-Zn-Sr alloys after solution treatment are plastically deformed, are adopted With mixing yoghurt technology, stirring-head rotating speed is 1000r/min, feed speed 120mm/min.
The room temperature tensile intensity of acquired alloy is 289MPa, elongation percentage 19%.
Embodiment 3
Magnesium alloy described in the present embodiment is made of Mg, Sn, Zn and Sr element, and each component mass percentage is：1.5% The total amount of Sn, 0.7%Zn, 0.05%Sr, impurity element S i, Fe, Cu and Ni are less than 0.02%, surplus Mg.
The preparation method of the alloy includes three melting, solution heat treatment and plastic deformation technique processes.
Wherein, preceding smelting technology process is in SF6And CO2It is carried out under the conditions of mixed gas protected, steps are as follows：It will be pure Magnesium melts in crucible electrical resistance furnace, and pure tin and pure zinc are added when temperature rises to 730 DEG C, and 10min is stirred after its fusing；Then Pure calcium is added, continuing stirring 10min keeps alloying elements distribution uniform.720 DEG C of heat preservation 10min are cooled to, fishing is removed surface scum, poured It notes and is preheated in 200 DEG C of metal type dies.
Subsequent solution heat treatment process is：The alloy cast ingot that melting is obtained keeps the temperature 12h, subsequent water at 450 DEG C It quenches to room temperature.
Subsequent plastic deformation process process is：Mg-Sn-Zn-Sr alloys after solution treatment are plastically deformed, are adopted With mixing yoghurt technology, stirring-head rotating speed is 1600r/min, feed speed 40mm/min.
The room temperature tensile intensity of acquired alloy is 299MPa, elongation percentage 22%.
It will be apparent to those skilled in the art that technical solution that can be as described above and design, make various other Corresponding change and deformation, and all these changes and deformation should all belong to the protection domain of the claims in the present invention Within.

Claims (4)

1. a kind of bio-medical Mg-Sn-Zn-Sr magnesium alloys comprising following weight percent composition：Sn 0.5-1.5%, Zn The total amount of 0.3-0.7%, Sr 0.05-0.15%, impurity element S i, Fe, Cu and Ni are less than 0.02%, surplus Mg.
2. a kind of preparation method of bio-medical Mg-Sn-Zn-Sr magnesium alloys described in claim 1, it is characterised in that：Including Following steps：
(1) melting is carried out under gas shield using pure magnesium ingot, pure tin ingot, pure zinc ingot and Mg-Sr intermediate alloys according to formula ratio, Obtain Mg-Sn-Zn-Sr systems magnesium alloy ingot；
(2) solution heat treatment is carried out to Mg-Sn-Zn-Sr systems magnesium alloy ingots, solid solution temperature is 350-450 DEG C, and the time is 12-24h, water quenching is to room temperature after solid solution；
(3) the Mg-Sn-Zn-Sr systems magnesium alloy after solution heat treatment is plastically deformed, using mixing yoghurt technology, Stirring-head rotating speed is 400-1600r/min, feed speed 40-200mm/min.
3. the heat treatment method of bio-medical Mg-Sn-Zn-Sr magnesium alloys according to claim 2, it is characterised in that：Step Suddenly protective gas is SF in (1)6With CO2Mixed gas.
4. the heat treatment method of bio-medical Mg-Sn-Zn-Sr magnesium alloys according to claim 2, it is characterised in that：Step Suddenly method of smelting is in (1)：First pure magnesium is melted, pure tin and pure zinc are added when temperature rises to 720-740 DEG C, after its fusing Stir 8-12min；Mg-10Sr intermediate alloys are then added, continuing stirring 8-12min keeps alloying elements distribution uniform, is cooled to 710-720 DEG C of heat preservation 10min, removes surface scum, is poured into the metal type dies for being preheated to 180-220 DEG C.
CN201810272939.1A 2018-03-29 2018-03-29 A kind of bio-medical Mg-Sn-Zn-Sr magnesium alloys and preparation method thereof Pending CN108411173A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810272939.1A CN108411173A (en) 2018-03-29 2018-03-29 A kind of bio-medical Mg-Sn-Zn-Sr magnesium alloys and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201810272939.1A CN108411173A (en) 2018-03-29 2018-03-29 A kind of bio-medical Mg-Sn-Zn-Sr magnesium alloys and preparation method thereof

Publications (1)

Publication Number Publication Date
CN108411173A true CN108411173A (en) 2018-08-17

Family

ID=63133885

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201810272939.1A Pending CN108411173A (en) 2018-03-29 2018-03-29 A kind of bio-medical Mg-Sn-Zn-Sr magnesium alloys and preparation method thereof

Country Status (1)

Country Link
CN (1) CN108411173A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110042289A (en) * 2019-04-18 2019-07-23 北京大学 A kind of magnesium alloy containing Sr
CN111676390A (en) * 2020-08-03 2020-09-18 北京科技大学 Zn-Ga alloy, preparation method and application thereof
CN114164370A (en) * 2021-12-09 2022-03-11 辽宁科技大学 Mg-based biological material based on high-entropy alloy theory and preparation method and application thereof
CN116024471A (en) * 2022-12-01 2023-04-28 中南大学 High-strength plastic multi-water-soluble channel magnesium alloy and preparation method thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101831580A (en) * 2010-04-19 2010-09-15 哈尔滨工程大学 Biomedical Mg-Sn-Mn series magnesium alloy and plate rolling process thereof
CN101869726A (en) * 2010-06-08 2010-10-27 东北大学 Mg-Zn-Sr alloy biomaterial of hydroxyapatite coating and preparation method thereof
CN102552973A (en) * 2012-02-17 2012-07-11 浙江海圣医疗器械有限公司 Medical degradable and absorbable Mg-Sr-Ca series magnesium alloy implant and preparation method thereof
CN102978495A (en) * 2012-12-13 2013-03-20 北京大学 Mg-Sr-Zn alloy and preparation method thereof
CN104328318A (en) * 2014-10-20 2015-02-04 东北大学 Preparation method of high-corrosion-resistance biodegradable magnesium alloy
CN105671391A (en) * 2016-01-19 2016-06-15 周倩 Full-degradable magnesium alloy and preparation method thereof

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101831580A (en) * 2010-04-19 2010-09-15 哈尔滨工程大学 Biomedical Mg-Sn-Mn series magnesium alloy and plate rolling process thereof
CN101869726A (en) * 2010-06-08 2010-10-27 东北大学 Mg-Zn-Sr alloy biomaterial of hydroxyapatite coating and preparation method thereof
CN102552973A (en) * 2012-02-17 2012-07-11 浙江海圣医疗器械有限公司 Medical degradable and absorbable Mg-Sr-Ca series magnesium alloy implant and preparation method thereof
CN102978495A (en) * 2012-12-13 2013-03-20 北京大学 Mg-Sr-Zn alloy and preparation method thereof
CN104328318A (en) * 2014-10-20 2015-02-04 东北大学 Preparation method of high-corrosion-resistance biodegradable magnesium alloy
CN105671391A (en) * 2016-01-19 2016-06-15 周倩 Full-degradable magnesium alloy and preparation method thereof

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110042289A (en) * 2019-04-18 2019-07-23 北京大学 A kind of magnesium alloy containing Sr
CN111676390A (en) * 2020-08-03 2020-09-18 北京科技大学 Zn-Ga alloy, preparation method and application thereof
CN114164370A (en) * 2021-12-09 2022-03-11 辽宁科技大学 Mg-based biological material based on high-entropy alloy theory and preparation method and application thereof
CN114164370B (en) * 2021-12-09 2022-05-27 辽宁科技大学 Mg-based biological material based on high-entropy alloy theory and preparation method and application thereof
CN116024471A (en) * 2022-12-01 2023-04-28 中南大学 High-strength plastic multi-water-soluble channel magnesium alloy and preparation method thereof

Similar Documents

Publication Publication Date Title
CN109097629B (en) Biodegradable Zn-Mo series zinc alloy and preparation method thereof
CN109972007B (en) Anastomosis nail material capable of degrading Mg-Zn-Ca-M in organism and preparation method thereof
CN108425051A (en) A kind of bio-medical Mg-Sn-Zn-Ca magnesium alloys and preparation method thereof
CN108411173A (en) A kind of bio-medical Mg-Sn-Zn-Sr magnesium alloys and preparation method thereof
CN107236886B (en) A kind of polynary Mg-Zn-Y-Ca-Zr alloys of medical degradable high-strength anticorrosion and preparation method thereof
CN108754232B (en) High-strength high-plasticity biodegradable Zn-Mn-Li series zinc alloy and application thereof
CN106702212A (en) Medical degradable Zn-Cu-X alloy material and preparation method thereof
CN102433477A (en) Biomedical Mg-Sn-Zn-Mn magnesium alloy and preparation method thereof
CN104762542B (en) Biomedical degradable absorption Mg-Sr-Cu alloy material, preparation method and application
CN105986146B (en) A kind of degradable medical is metal material embedded and preparation method thereof
CN103740982A (en) Metastable beta titanium alloy with low elastic modulus and preparing method thereof
CN109602960B (en) Preparation method of medical zinc alloy bar with superplasticity
CN104498790A (en) Degradable magnesium alloy bio-implantation material and preparation method thereof
CN105401033B (en) High strength and toughness anti-corrosion biomedical magnesium alloy
CN102258806B (en) Degradable magnesium-base biomedical material for implantation in orthopaedics, and preparation method thereof
CN108677074A (en) A kind of medical degradable corrosion-resistant magnesium alloy bracket and preparation method thereof of implantation heart
CN104120320A (en) Degradable rare earth magnesium alloy medical biomaterial and preparation method thereof
CN103184379A (en) Biodegradable Mg-Gd-Zn-Ag-Zr series magnesium alloy and preparation method thereof
CN107541631A (en) A kind of biological medical degradable corrosion-proof and high-strength tough magnesium alloy and preparation method thereof
CN100372574C (en) Multi-elements magnesium alloy contg. Mg-Zn-Ca-Fe of bio-absorbable type
CN106282664A (en) Biodegradable medical zinc lithium binary alloy material and preparation method and application
WO2020042745A1 (en) Mg-zn-sn series magnesium alloy with controllable degradation rate, preparation method and application thereof
CN114318187B (en) Biomedical high-purity high-strength corrosion-resistant Mg-Zn-Mn magnesium alloy wire and preparation method thereof
CN108359868A (en) It is a kind of to be used to be implanted into magnesium alloy of bone and preparation method thereof
CN108277407A (en) A kind of intravascular stent degradable corrosion-resistant magnesium alloy and preparation method thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20180817

RJ01 Rejection of invention patent application after publication