CN108405003A - A kind of micro-fluidic chip and application method of the double emulsion droplets shells of stripping - Google Patents
A kind of micro-fluidic chip and application method of the double emulsion droplets shells of stripping Download PDFInfo
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- CN108405003A CN108405003A CN201810221384.8A CN201810221384A CN108405003A CN 108405003 A CN108405003 A CN 108405003A CN 201810221384 A CN201810221384 A CN 201810221384A CN 108405003 A CN108405003 A CN 108405003A
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- emulsion droplets
- double emulsion
- shell
- double
- speed governing
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
Abstract
The invention discloses the micro-fluidic chip and application method of a kind of double emulsion droplets shells of stripping, the double emulsion droplets outlets of shell, shell single emulsion ooze the double emulsion droplets discharge couplings of mouth, double emulsion droplets injection inlets, speed governing traffic ingress, shell, shell single emulsion drop discharge coupling, double emulsion droplets injection inlet interfaces and speed governing traffic ingress interface it is equal based on pore space structure on solid structure.Groove structure based on the double emulsion droplets observation ward of shell, shell single emulsion drop observation ward, outer shroud bypass passage, inner ring bypass passage, shell stripping bifurcation, double emulsion droplets upstream passageways, taper speed governing traffic channel, double emulsion droplets accelerated passages, arc centrifugal channel are equal on solid structure.Mask plate is made, recycles the methods of photoetching, etching that its model etching on solid substrate, is then carried out device encapsulation.When using high molecular material as chip material, finally obtained macromolecule chip is pasted on glass slide to get to micro-fluidic chip provided by the present invention.
Description
Technical field
The present invention relates to the micro-fluidic chips and application method of a kind of double emulsion droplets shells of stripping, belong to based on micro-fluidic core
Drop microfluidic art in piece.
Background technology
Double emulsion droplets are that the highly structural complexity heterogeneous system of the immiscible drop of smaller is enclosed in a kind of discrete phase drop
System, unique nucleocapsid structure can in effective protection kernel sample not by complicated external environmental, pharmaceutical carrier,
The fields such as self-repair technology and photonic crystal all have huge application potential.
Drop microflow control technique is that a kind of research micro-meter scale microlayer model to grow up in recent years is generated, manipulates and applied
New technology.The technology has the characteristics that stable, easy to operate and applied widely, is widely used to medicament transport, disease at present
The numerous areas such as disease protection, cell research and functional material preparation are the research hotspots of domestic and international each related discipline at present.Mesh
Before, the micro-fluidic generating means for preparing double emulsion droplets mainly use the coaxial flow microchannel based on glass micro capillary, due to boundary
The characteristics of face is deformable and limited space, double emulsion droplets monodispersities prepared by the device are good, structure-controllable, ratio of defects are low.
The microcapsules that these drops can generate for modes such as later use chemical polymerization, ultraviolet light solidifications provide the template of high quality.
Existing document points out that the increase of double emulsion droplets shell thicknesses can cause interior drop that relative flow occurs, and cause it in crosslinking curing
It is easier to rupture in the process, to improve the product defects rate of microcapsules.And for the double emulsion droplets of shell, the lubrication of liquid film
Effect can inhibit double emulsion droplets to rupture in the curing process.Therefore, under the premise of ensureing performance, prepared by microcapsules
Personnel are always desirable to reduce the shell thickness of double emulsion droplets.On the other hand, different application scenarios also require microcapsules to answer
It is of different sizes.
It intercouples however, double emulsion droplets its inside and outside drop size in generating process exists, such as reduces interior drop ruler
It is very little would generally be along with the increase of double emulsion droplets shell thickness, and then lead to the defect rate rises of microcapsule product, this so that life is applied alone
It is difficult to meet the needs of some application fields at device, limits microfluidic method and generate double this technology of emulsion droplets in the industry
Further popularize.The present invention is this easy to be reliable by drop breakup and is easy to compatible liquid drop control technology, to double emulsion droplets
Extra shell remove, and in conjunction with the hydrodynamic characteristics inside double emulsion droplets, can realize to the double lotions of different sizes
The shell thickness of drop is effectively reduced.
Invention content
Based on current background, for removing to the extra shell of double emulsion droplets, the present invention combines in double emulsion droplets
The hydrodynamic characteristics in portion realize that the shell thickness to the double emulsion droplets of different sizes is effectively reduced.Pass through above functions
Description, the double emulsion droplets templates being not easily broken in crosslinking curing can be provided for microcapsules related industry, reduce microcapsule product
Ratio of defects.
To achieve the above object, solution of the invention is a kind of micro-fluidic core that double emulsion droplets shell strippings can be achieved
Piece, the micro-fluidic chip include that the double emulsion droplets outlet 1 of shell, shell single emulsion ooze mouth 2, shell double emulsion droplets observation ward 3, shells
Layer single emulsion drop observation ward 4, outer shroud bypass passage 5, inner ring bypass passage 6, shell stripping bifurcation 7, double emulsion droplets are injected into
Mouth 8, speed governing traffic ingress 9, double emulsion droplets upstream passageways 10, taper speed governing traffic channel 11, double emulsion droplets accelerated passages 12, arc
The double emulsion droplets discharge couplings 14 of shape centrifugal channel 13, shell, shell single emulsion drop discharge coupling 15, double emulsion droplets injection inlets connect
Mouth 16, speed governing traffic ingress interface 17, bottom plate 18 and main body solid structure 19.
Preferably, in the micro-fluidic chip provided by the invention that double emulsion droplets shell strippings can be achieved, the double breasts of the shell
Drop outlets 1, shell single emulsion ooze the double emulsion droplets outlets of mouth 2, double emulsion droplets injection inlets 8, speed governing traffic ingress 9, shell
Interface 14, shell single emulsion drop discharge coupling 15, double emulsion droplets injection inlet interfaces 16 and speed governing traffic ingress interface 17 are
Pore space structure on main body solid structure 19.The double emulsion droplets observation ward 3 of shell, shell single emulsion drop observation ward 4, outer shroud branch are logical
Road 5, inner ring bypass passage 6, shell stripping bifurcation 7, double emulsion droplets upstream passageways 10, taper speed governing traffic channel 11, double breasts
Groove structure based on drop accelerated passage 12, arc centrifugal channel 13 are equal on solid structure 19.Pore space structure and groove knot
Structure is the flow region of fluid when micro-fluidic chip works.
Preferably, in the micro-fluidic chip provided by the invention that double emulsion droplets shell strippings can be achieved, bottom plate 18 is placed in master
Under body solid structure 19, bottom plate 18 is to supportive body solid structure 19 and is closed the groove knot on 19 surface of main body solid structure
Structure forms closed fluid flow region.
Preferably, in the micro-fluidic chip provided by the invention that double emulsion droplets shell strippings can be achieved, the double breasts of the shell
Drop outlets interface 14, shell single emulsion drop discharge coupling 15, double emulsion droplets injection inlet interfaces 16, speed governing traffic ingress interface
17 are used for connecting conduit, and double emulsion droplets injection inlet interfaces 16 to inject the double emulsion droplets prepared, inject by double emulsion droplets
Ingress interface 16 is connected with double emulsion droplets injection inlets 8, and double emulsion droplets injection inlets 8 directly connect with double emulsion droplets upstream passageways 10
It connects, double emulsion droplets injection inlets 8 are used to double emulsion droplets being transported to be led to by taper speed governing traffic channel 11 and double emulsion droplets upstreams
The speed governing river conjunction position that road 10 forms.
Preferably, in the micro-fluidic chip provided by the invention that double emulsion droplets shell strippings can be achieved, speed governing traffic ingress
Interface 17 injects continuous phase liquid for connecting conduit, and speed governing traffic ingress interface 17 is connected with speed governing traffic ingress 9, speed governing stream
Amount entrance 9 is directly connected to taper speed governing traffic channel 11, and taper speed governing traffic channel 11 accesses double emulsion droplets upstream passageways 10.
Preferably, in the micro-fluidic chip provided by the invention that double emulsion droplets shell strippings can be achieved, double emulsion droplets upstreams
Channel 10 is connected directly with double emulsion droplets accelerated passages 12, and double 12 downstreams of emulsion droplets accelerated passage are arc centrifugal channels 13.
Preferably, in the micro-fluidic chip provided by the invention that double emulsion droplets shell strippings can be achieved, arc centrifugal channel
13 downstreams are shell stripping bifurcations 7, shell remove bifurcation 7 arc centrifugal channel 13 is divided for outer shroud bypass passage 5 and
6 two branches of inner ring bypass passage.
Preferably, in the micro-fluidic chip provided by the invention that double emulsion droplets shell strippings can be achieved, outer shroud bypass passage 5
Observation ward 4 connect with shell single emulsion drop, and inner ring bypass passage 6 is connect with shell pair emulsion droplets observation ward 3.
Preferably, in the micro-fluidic chip provided by the invention that double emulsion droplets shell strippings can be achieved, shell single emulsion drop
Observation ward 4 oozes mouth 2 with shell single emulsion and connect, and the double emulsion droplets observation ward 3 of shell export 1 with the double emulsion droplets of shell and connect.Shell
Layer single emulsion oozes mouth 2 and is connected with shell single emulsion drop discharge coupling 15, the double emulsion droplets outlets 1 of shell and the double emulsion droplets of shell
Discharge coupling 14 is connected.The shell pair emulsion droplets completed are removed to flow into and shell pair by shell pair emulsion droplets discharge coupling 14
The conduit that emulsion droplets discharge coupling 14 is connected, into liquid storage tank.
The main body solid structure 19 and bottom plate 18 are completed to be bonded by plasma cleaning technology.
The main body solid structure 19 and bottom plate 18 match curing agent by dimethyl silicone polymer and stir evenly, and
It is cast in silicon chip template, is heating and curing and is made.The micro-fluidic chip that this method is made has the good transparency, side
Just double emulsion droplets inside microscopic micro-fluidic chip is utilized to remove situation.
Compared with prior art, the present invention has the advantages that：
1, the advantage of the invention is that process is automatic, the high-throughput production of the double emulsion droplets of shell can be realized.
2, the advantage of the invention is that various sizes of double emulsion droplets can be suitable for, there is good compatibility.
Description of the drawings
Technical solution in implementing in order to illustrate more clearly of the present invention below makees required applicable attached drawing in embodiment
Simple declaration.Obviously, described attached drawing be the present invention a part of the embodiment rather than whole embodiments, related field
Technical staff without creative efforts, can also be obtained according to these attached drawings the design side of other similar characteristics
Case and design scheme attached drawing.
Fig. 1 is the three-dimensional perspective schematic diagram of the micro-fluidic chip provided by the invention that double emulsion droplets shell strippings can be achieved.
Fig. 2 is the floor map of the micro-fluidic chip provided by the invention that double emulsion droplets shells strippings can be achieved and double
The schematic diagram of emulsion droplets shell stripping process.
Specific implementation mode
The technique effect of the design of the present invention, concrete outcome and generation is carried out below with reference to embodiment and attached drawing clear
Chu, complete description, to be completely understood by the purpose of the present invention, feature and effect.Obviously, described attached drawing is this hair
Bright a part of the embodiment rather than whole embodiments, those skilled in the relevant art are without creative efforts
The other embodiment obtained, and the invention design with similar characteristics combination, all belong to the scope of protection of the present invention.This hair
Each technical characteristic in bright creation, can be with other creative feature combination of interactions under the premise of not conflicting conflict.
Embodiment 1：
The manufacture craft of micro-fluidic chip is the technology of current comparative maturity, and those skilled in the art can be according to its tool
Special, the suitable technique of industry knowledge-chosen having are realized, glass, silicon materials or each high molecular material such as poly dimethyl silicon can be used
The material as micro-fluidic chip such as oxygen alkane, epoxy resin and polyurethane.Preferably, using the object with waterproof or grease proofness
Material of the matter as micro-fluidic chip.When doing chip using glass material, mask plate is made first, recycles photoetching, etching etc.
Method etches its model on solid substrate, then carries out device encapsulation.When using high molecular material as chip material, system
It is as process：Mask blank, photoetching replicate template and bottom plate bonding, obtained macromolecule chip are finally pasted load glass
On piece is to get to micro-fluidic chip provided by the present invention.Each interface on the micro-fluidic chip passes through plastic tube, glass tube
It is connected Deng with fluid pump, flow rate of liquid is controlled by fluid pump.
Fig. 1 is the three-dimensional perspective schematic diagram of the micro-fluidic chip provided by the invention that double emulsion droplets shell strippings can be achieved.
The micro-fluidic chip includes that the double emulsion droplets outlet 1 of shell, shell single emulsion ooze mouth 2, shell double emulsion droplets observation ward 3, shells
Single emulsion drips observation ward 4, outer shroud bypass passage 5, inner ring bypass passage 6, shell stripping bifurcation 7, double emulsion droplets injection inlets
8, speed governing traffic ingress 9, double emulsion droplets upstream passageways 10, taper speed governing traffic channel 11, double emulsion droplets accelerated passages 12, arc
The double emulsion droplets discharge couplings 14 of centrifugal channel 13, shell, shell single emulsion drop discharge coupling 15, double emulsion droplets injection inlet interfaces
16, speed governing traffic ingress interface 17, bottom plate 18, main body solid structure 19.
In the micro-fluidic chip provided by the invention that double emulsion droplets shell strippings can be achieved, 19 He of main body solid structure
Bottom plate 18 can be completed to be bonded by plasma cleaning technology, and bottom plate 18 is placed under main body solid structure 19, to supportive body
Solid structure 19 and the groove structure for being closed 19 surface of main body solid structure, form closed fluid flow region.The main body
Solid structure 19 and bottom plate 18 can match curing agent by dimethyl silicone polymer and stir evenly, and be cast in silicon chip template
On, it is heating and curing and is made.The micro-fluidic chip of the present invention that this method is made has the good transparency, can facilitate
Situation is removed using double emulsion droplets inside microscopic micro-fluidic chip.
Preferably, glass micro capillary may be used and carry out double emulsion droplets preparations.Preferably, working material can be：It is interior
Portion's water phase is the glycerine water solution of 5wt%, and intermediate oil phase is silicone oil and dimethione is 7 by volume:3 mixing is molten
Liquid, outer water phase are polyvinyl alcohol (PVA, 87% -89%) aqueous solution of 5wt%.
During generating double emulsion droplets, physical parameter, flow-rate ratio of three-phase liquid etc. have a significant impact its flow pattern.
Preferably, internal water phase flow rate Q1=60~600 μ L/h, the middle oil phase flow rate μ of Q2=300~3600 L/h and outer can be adjusted
The portion water phase flow μ of Q3=1200~18000 L/h.At this point, about 300-500 μm of the size of double emulsion droplets outer diameters.
In the micro-fluidic chip provided by the invention that double emulsion droplets shell strippings can be achieved, double emulsion droplets injection inlet interfaces
16 can be to inject the double emulsion droplets prepared, double emulsion droplets injection inlet interfaces 16 and double 8 phases of emulsion droplets injection inlet
Even, double emulsion droplets injection inlets 8 are directly connected to double emulsion droplets upstream passageways 10, for being transported to double emulsion droplets by taper speed governing
The speed governing river conjunction position of traffic channel 11 and double 10 compositions of emulsion droplets upstream passageway.
In the micro-fluidic chip provided by the invention that double emulsion droplets shell strippings can be achieved, speed governing traffic ingress interface 17 is used
Continuous phase liquid is injected in connecting conduit, speed governing traffic ingress interface 17 is connected with speed governing traffic ingress 9, speed governing traffic ingress 9
It is directly connected to taper speed governing traffic channel 11, taper speed governing traffic channel 11 accesses double emulsion droplets upstream passageways 10.Taper speed governing
The conical opening design of traffic channel 11 can improve local flow resistance, and on the other hand, cone mouth is sized to be less than usual pair
The size of emulsion droplets can be made in terms of flow resistance and geometry two for avoiding double emulsion droplets from entering taper speed governing traffic channel 11
At rupturing in advance.
Preferably, in the micro-fluidic chip provided by the invention that double emulsion droplets shell strippings can be achieved, double emulsion droplets upstreams
Channel 10 is connected directly with double emulsion droplets accelerated passages 12, and double 12 downstreams of emulsion droplets accelerated passage are arc centrifugal channels 13.Through
The continuous phase flow rate of injection of taper speed governing traffic channel 11 is crossed, double emulsion droplets improve movement speed in double emulsion droplets accelerated passages 12
Degree passes through arc centrifugal channel 13 with higher speed, and outer drop inner loop stream, interior drop will be tight caused by centrifugal action
Internal face by arc centrifugal channel 13 is excessively curved, as shown in Figure 2.According to various sizes of double emulsion droplets, due to quality and it is limited
Degree is different, preferably changes the continuous phase uninterrupted of the injection of taper speed governing traffic channel 11, ensures that interior drop can abut arc
13 inside of centrifugal channel.
When higher motion speed, and interior drop removes bifurcation 7, double breasts against double emulsion droplets contact shell of internal face
Drop will be stripped as single emulsion drop and the double emulsion droplets of a shell, respectively enter outer shroud bypass passage 5 and inner ring branch
6 two branches of paths.In the micro-fluidic chip provided by the invention that double emulsion droplets shell strippings can be achieved, outer shroud bypass passage
5 and 6 two branches of inner ring bypass passage be separately connected shell single emulsion drop observation ward 4 and the double emulsion droplets observation ward of shell 3.By
It is reduced in cross-sectional area expansion flow velocity, drop can be double by shell single emulsion drop observation ward 4 and shell with lower movement velocity
Emulsion droplets observation ward 3, at this point, implement personnel can the double emulsion droplets of aspect observation be stripped after form and extent of exfoliation.
In the micro-fluidic chip provided by the invention that double emulsion droplets shell strippings can be achieved, shell single emulsion drips observation ward 4
It is directly connected to shell single emulsion respectively with shell pair emulsion droplets observation ward 3 and oozes mouth 2 and shell pair emulsion droplets outlet 1.It is corresponding,
Shell single emulsion oozes mouth 2 and the double emulsion droplets of shell export 1 and drip discharge coupling 15 and the double lotions of shell with shell single emulsion respectively
Drop discharge coupling 14 is connected.The double emulsion droplets of shell for removing completion are flowed by shell pair emulsion droplets discharge coupling 14 and shell
The conduit that double emulsion droplets discharge couplings 14 are connected is processed into liquid storage tank for subsequent cure.
The preferable embodiment of the present invention is illustrated above.It is emphasized that but the invention simultaneously
It is not limited to the embodiment, those skilled in the art can also make various under the premise of without prejudice to spirit of that invention
Equivalent modifications or replacement, these modifications or replacement with similar characteristics are all contained in model defined by the application claim
In enclosing.
Claims (3)
1. a kind of micro-fluidic chip of the double emulsion droplets shells of stripping, it is characterised in that：The micro-fluidic chip includes the double lotions of shell
Ooze mouth (1), shell single emulsion oozes the double emulsion droplets observation ward (3) of mouth (2), shell, shell single emulsion drips observation ward (4), outer
Ring bypass passage (5), inner ring bypass passage (6), shell stripping bifurcation (7), double emulsion droplets injection inlets (8), speed governing flow
Entrance (9), double emulsion droplets upstream passageways (10), taper speed governing traffic channel (11), double emulsion droplets accelerated passages (12), arc from
Heart channel (13), the double emulsion droplets discharge couplings (14) of shell, shell single emulsion drop discharge coupling (15), double emulsion droplets injection inlets
Interface (16), speed governing traffic ingress interface (17), bottom plate (18) and main body solid structure (19)；
The double emulsion droplets outlets (1) of the shell, shell single emulsion ooze mouth (2), double emulsion droplets injection inlets (8), speed governing flow
The double emulsion droplets discharge couplings (14) of entrance (9), shell, shell single emulsion drop discharge coupling (15), double emulsion droplets injection inlets connect
Pore space structure based on mouthful (16) and speed governing traffic ingress interface (17) are equal on solid structure (19)；The double emulsion droplets observations of shell
Room (3), shell single emulsion drop observation ward (4), outer shroud bypass passage (5), inner ring bypass passage (6), shell remove bifurcation
(7), double emulsion droplets upstream passageways (10), taper speed governing traffic channel (11), double emulsion droplets accelerated passages (12), arc centrifugation are logical
Groove structure based on road (13) is equal on solid structure (19)；Pore space structure and groove structure are that micro-fluidic chip flows when working
The flow region of body；
Bottom plate (18) is placed under main body solid structure (19), and bottom plate (18) is to supportive body solid structure (19) and is closed master
The groove structure on body solid structure (19) surface, forms closed fluid flow region；
The double emulsion droplets discharge couplings (14) of the shell, shell single emulsion drop discharge coupling (15), double emulsion droplets injection inlets connect
Mouth (16), speed governing traffic ingress interface (17) are used for connecting conduit, and double emulsion droplets injection inlet interfaces (16) have been made to inject
The double emulsion droplets got ready, double emulsion droplets injection inlet interfaces (16) are connected with double emulsion droplets injection inlets (8), double emulsion droplets injections
Entrance (8) is directly connect with double emulsion droplets upstream passageways (10), and double emulsion droplets for being transported to by double emulsion droplets injection inlets (8)
The speed governing river conjunction position being made of taper speed governing traffic channel (11) and double emulsion droplets upstream passageways (10)；
Speed governing traffic ingress interface (17) injects continuous phase liquid, speed governing traffic ingress interface (17) and speed governing for connecting conduit
Traffic ingress (9) is connected, and speed governing traffic ingress (9) is directly connected to taper speed governing traffic channel (11), taper speed governing traffic channel
(11) double emulsion droplets upstream passageways (10) are accessed；
Double emulsion droplets upstream passageways (10) are connected directly with double emulsion droplets accelerated passages (12), under double emulsion droplets accelerated passages (12)
Trip is arc centrifugal channel (13)；
Arc centrifugal channel (13) downstream is shell stripping bifurcation (7), and shell removes bifurcation (7) by arc centrifugal channel
(13) it is divided into (6) two branches of outer shroud bypass passage (5) and inner ring bypass passage；
Outer shroud bypass passage (5) is connect with shell single emulsion drop observation ward (4), inner ring bypass passage (6) and the double emulsion droplets of shell
Observation ward (3) connects.
Shell single emulsion drop observation ward (4) oozes mouth (2) with shell single emulsion and connect, shell pair emulsion droplets observation ward (3) with it is thin
Double emulsion droplets outlet (1) connections of shell；Shell single emulsion oozes mouth (2) and is connected with shell single emulsion drop discharge coupling (15), thin
The double emulsion droplets outlets (1) of shell are connected with the double emulsion droplets discharge couplings (14) of shell；The double emulsion droplets of the shell completed are removed to pass through
The double emulsion droplets discharge couplings (14) of shell flow into the conduit being connected with the double emulsion droplets discharge couplings (14) of shell, into liquid storage
Pond.
2. a kind of micro-fluidic chip of the double emulsion droplets shells of stripping according to claim 1, it is characterised in that：The main body
Solid structure (19) and bottom plate (18) are completed to be bonded by plasma cleaning technology.
3. a kind of micro-fluidic chip of the double emulsion droplets shells of stripping according to claim 1, it is characterised in that：The main body
Solid structure (19) and bottom plate (18) match curing agent by dimethyl silicone polymer and stir evenly, and are cast in silicon chip mould
On plate, it is heating and curing and is made.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810221384.8A CN108405003B (en) | 2018-03-17 | 2018-03-17 | Micro-fluidic chip for stripping double emulsion drop shells and use method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810221384.8A CN108405003B (en) | 2018-03-17 | 2018-03-17 | Micro-fluidic chip for stripping double emulsion drop shells and use method |
Publications (2)
| Publication Number | Publication Date |
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| CN108405003A true CN108405003A (en) | 2018-08-17 |
| CN108405003B CN108405003B (en) | 2019-12-27 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201810221384.8A Active CN108405003B (en) | 2018-03-17 | 2018-03-17 | Micro-fluidic chip for stripping double emulsion drop shells and use method |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110496657A (en) * | 2019-09-11 | 2019-11-26 | 苏州大学 | A kind of micro-fluidic chip and preparation method thereof forming liquid metal droplet |
| CN113413936A (en) * | 2021-08-24 | 2021-09-21 | 北京寻因生物科技有限公司 | Flow regulation structure and microfluid chip |
| CN114292734A (en) * | 2021-12-22 | 2022-04-08 | 上海前瞻创新研究院有限公司 | Full-process integrated droplet digital PCR chip, preparation method and application |
| CN114870916A (en) * | 2022-05-06 | 2022-08-09 | 中新国际联合研究院 | Microfluid liquid drop moving, stripping and separating stripping structure and method |
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| ANTOINE VIAN等: "Reducing the shell thickness of double emulsions using microfluidics", 《MICROFLUID NANOFLUID》 * |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110496657A (en) * | 2019-09-11 | 2019-11-26 | 苏州大学 | A kind of micro-fluidic chip and preparation method thereof forming liquid metal droplet |
| CN110496657B (en) * | 2019-09-11 | 2022-04-22 | 苏州大学 | Microfluidic chip capable of forming liquid metal droplets and preparation method thereof |
| CN113413936A (en) * | 2021-08-24 | 2021-09-21 | 北京寻因生物科技有限公司 | Flow regulation structure and microfluid chip |
| CN114292734A (en) * | 2021-12-22 | 2022-04-08 | 上海前瞻创新研究院有限公司 | Full-process integrated droplet digital PCR chip, preparation method and application |
| CN114292734B (en) * | 2021-12-22 | 2023-08-18 | 上海前瞻创新研究院有限公司 | Full-flow integrated liquid drop digital PCR chip, preparation method and application |
| CN114870916A (en) * | 2022-05-06 | 2022-08-09 | 中新国际联合研究院 | Microfluid liquid drop moving, stripping and separating stripping structure and method |
| CN114870916B (en) * | 2022-05-06 | 2023-12-05 | 中新国际联合研究院 | Micro-fluid droplet moving, stripping and separating stripping structure and method |
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| Publication number | Publication date |
|---|---|
| CN108405003B (en) | 2019-12-27 |
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