CN108404226A - A kind of preparation method of high-compatibility coating bracket material - Google Patents
A kind of preparation method of high-compatibility coating bracket material Download PDFInfo
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- CN108404226A CN108404226A CN201810514700.0A CN201810514700A CN108404226A CN 108404226 A CN108404226 A CN 108404226A CN 201810514700 A CN201810514700 A CN 201810514700A CN 108404226 A CN108404226 A CN 108404226A
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- coating bracket
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- mass ratio
- bracket material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/082—Inorganic materials
- A61L31/086—Phosphorus-containing materials, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/146—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
Abstract
The present invention relates to a kind of preparation methods of high-compatibility coating bracket material, belong to medical material tech field.Technical solution of the present invention uses nano-calcium carbonate as raw material and prepares porous hydroxyapatite particles,Bovine serum albumin liquid is coated and loaded by Apatite materials porous hole and cladding is formed to coating bracket surface by vacuum atomizing,The surface of timbering material is adsorbed on by modified gel liquid,Then pass through the change of protein molecular conformation,Enhance boundary lubrication,Greatly reduce the compatibility performance between holder surface layer and human body,Effectively extend the service life of implantation prosthese,And technical solution of the present invention is used using chitosan etc. as carrier,Cover the outside of coating bracket,Form the outer wall layer of bracket coating,Holder is realized when being contacted with contacting blood and tissue,With excellent compatibility performance,Simultaneously because the sustained release performance of phosphorus lime material,The protein material compatible with human body can be released effectively,Make coating bracket that there is excellent compatibility performance.
Description
Technical field
The present invention relates to a kind of preparation methods of high-compatibility coating bracket material, belong to medical material tech field.
Background technology
Coating stent of medicine also known as bracket for eluting medicament carry drug using polymer support, keep drug locally slow
On The Drug Release.Sirolimus-eluting stents and Paclitaxel-Eluting have obtained U.S.'s FAD certifications.SE passes through contained Xi Luomo
Department prevents cell G1 phases to the S phases from converting inhibition cell Proliferation, to inhibit neointimal hyperplasia and then preventing in-stent restenosis.
Have researcher to after implantation left main coronary 4 years SES angiographies and intravascular ultrasound observation find that holder is without apparent
ISR phenomenons, and had been found that serious ISR in the continuation follow-up after the 7th year.According to pertinent literature, the advanced thrombus of SES
Rate is less than 0.6%, and pole advanced thrombus rate is about 0.9%, but case fatality rate is up to 40%, so the safety of the SES of the first generation and remote
Phase curative effect receives query.PES makes cell division arrest in G2/ mainly by the formation of the taxol interference cell micro-pipe of release
The M phases.Compared with BMS, significantly reduced compared to PES restenosis rates.To undergoing the ST sections property raised of percutaneous coronary intervention (pci)
Myocardial infarction patient is carried out in long term follow-up, and PES can reduce lesion vessels revascularization rate, finds the death rate of PES patient
With internal stent thrombosis incidence compared with being implanted into bare bracket patient without significant difference, but pole advanced thrombus incidence increases.
Different coating process strong influence coating productions include physical method and chemical method.Physical method has
It impregnates, dipping, spray, layer-by-layer.First three spraying method is conventional spraying technology, and dip coating is easy to operate,
But coating is uneven；Spray coating method recoating efficiency is low；Painting method coating uniformity is poor.Simultaneously existing coating bracket material due to
Compatibility is poor, causes the binding performance of material not high, so how to carry out effective modification to it is prior art research
Emphasis where.
Invention content
The technical problems to be solved by the invention：The poor while recoating efficiency for existing coating bracket material compatible performance
Relatively low problem provides a kind of preparation method of high-compatibility coating bracket material.
In order to solve the above technical problems, the technical solution adopted by the present invention is：
（1）In mass ratio 1:5, bovine serum albumin liquid is added in absolute ethyl alcohol, after being stirred, collects to obtain colloidal solution juxtaposition
In bag filter, bag filter is placed in deionized water, dialysis treatment is stood, collects to obtain dialyzate；
（2）In mass ratio 1:10, nano-calcium carbonate is added in deionized water, is stirred and ultrasonic disperse obtains suspension simultaneously
In mass ratio 1:8, disodium phosphate soln is added dropwise in suspension, simultaneously insulation reaction is stirred after being added dropwise to complete, it is quiet
It sets and is cooled to room temperature, adjust pH to 10.5, it is still aging and filter, it collects filter residue and washs dry dried powder；
（3）In mass ratio 1:5, dialyzate and dried powder are stirred and are placed in mortar, grinding distribution collects to obtain dispersion
Slurries；
（4）It counts in parts by weight, weighs 45~50 parts of deionized waters, 10~15 parts of chitosans and 25~35 parts of dispersion slurries respectively
It is placed in mortar, grinding distribution is placed in Ultrasonic spraying device, and ultrasonic atomizatio handles and is sprayed into 316L stainless steel branch
Frame tube chamber layer surface, the high-compatibility coating bracket material can be prepared by standing solidification.
Step（1）The bag filter is the bag filter of 8000~14000 molecular weight.
Step（2）The disodium phosphate soln drop rate is 2~3mL/min.
Step（4）The described ultrasonic atomizatio processing is 3~5MPa not adjust pressure, nozzle and holder distance for 3~
5cm, spray treatment.
Compared with other methods, advantageous effects are the present invention：
（1）Technical solution of the present invention uses nano-calcium carbonate as raw material and prepares porous hydroxyapatite particles, passes through apatite
Material porous hole coats and loads bovine serum albumin liquid and forms cladding to coating bracket surface, by changing by vacuum atomizing
Property coagulant liquid be adsorbed on the surface of timbering material, then by the change of protein molecular conformation, enhance boundary lubrication, substantially reduce
Compatibility performance between holder surface layer and human body effectively extends the service life of implantation prosthese；
（2）Technical solution of the present invention uses the outside that coating bracket is covered using chitosan etc. as carrier, forms bracket coating
Outer wall layer, realize holder when being contacted with contacting blood and tissue, have excellent compatibility performance, simultaneously because phosphorus lime
The sustained release performance of material can be released effectively the protein material compatible with human body, and coating bracket is made to have excellent compatibility performance.
Specific implementation mode
In mass ratio 1:5,5% bovine serum albumin liquid of mass fraction is added in absolute ethyl alcohol, 2~3h is stirred
Afterwards, collect colloidal solution is placed in the bag filter of 8000~14000 molecular weight, bag filter is placed in deionized water, stand
30~35h of dialysis treatment collects to obtain dialyzate and in mass ratio 1:5, dialyzate is stirred to be placed in dried powder and is ground
In alms bowl, grinding distribution collects to obtain dispersion slurries；In mass ratio 1:10, nano-calcium carbonate is added in deionized water, stirring is mixed
Merge ultrasonic disperse and obtains suspension and in mass ratio 1:8,10% disodium phosphate soln of mass fraction is added dropwise in suspension,
Control drop rate is 2~3mL/min, is stirred after being added dropwise to complete and is placed in 2~3h of insulation reaction at 55~65 DEG C, quiet
It sets and is cooled to room temperature, pH to 10.5 is adjusted with 5% sodium hydroxide solution of mass fraction, it is still aging and filter, collect filter residue simultaneously
It is rinsed 3~5 times with absolute ethyl alcohol, vacuum freeze drying obtains dried powder；Count in parts by weight, respectively weigh 45~50 parts go from
Sub- water, 10~15 parts of chitosans, 6~8 parts of dried powders and 25~35 parts of dispersion slurries are placed in mortar, and grinding distribution is placed in
In Ultrasonic spraying device, adjusting pressure is 3~5MPa, and nozzle is 3~5cm with holder distance, is sprayed into 316L stainless steels
Stand tube cavity layer surface, the high-compatibility coating bracket material can be prepared by standing solidification.
Example 1
In mass ratio 1:5,5% bovine serum albumin liquid of mass fraction is added in absolute ethyl alcohol, after being stirred 2h, is collected
Colloidal solution is placed in the bag filter of 8000 molecular weight, and bag filter is placed in deionized water, stands dialysis treatment 30h, is collected
Obtain dialyzate and in mass ratio 1:5, dialyzate and dried powder are stirred and are placed in mortar, grinding distribution collects score
Dissipate slurries；In mass ratio 1:10, nano-calcium carbonate is added in deionized water, is stirred and ultrasonic disperse obtains suspension simultaneously
In mass ratio 1:8,10% disodium phosphate soln of mass fraction is added dropwise in suspension, control drop rate is 2mL/min,
It is stirred after being added dropwise to complete and is placed in insulation reaction 2h, standing at 55 DEG C and is cooled to room temperature, with 5% hydroxide of mass fraction
Sodium solution adjusts pH to 10.5, still aging and filter, and collects filter residue and is simultaneously rinsed 3 times with absolute ethyl alcohol, vacuum freeze drying obtains
Dried powder；It counts in parts by weight, weighs 45 parts of deionized waters, 10 parts of chitosans, 6 parts of dried powders and 25 parts of dispersion pulps respectively
Liquid is placed in mortar, and grinding distribution is placed in Ultrasonic spraying device, and adjusting pressure is 3MPa, and nozzle is with holder distance
3cm is sprayed into 316L stainless steel stent tube chamber layer surfaces, and the high-compatibility coating bracket material can be prepared by standing solidification
Material.
Example 2
In mass ratio 1:5,5% bovine serum albumin liquid of mass fraction is added in absolute ethyl alcohol, after being stirred 2h, is collected
Colloidal solution is placed in the bag filter of 9000 molecular weight, and bag filter is placed in deionized water, stands dialysis treatment 32h, is collected
Obtain dialyzate and in mass ratio 1:5, dialyzate and dried powder are stirred and are placed in mortar, grinding distribution collects score
Dissipate slurries；In mass ratio 1:10, nano-calcium carbonate is added in deionized water, is stirred and ultrasonic disperse obtains suspension simultaneously
In mass ratio 1:8,10% disodium phosphate soln of mass fraction is added dropwise in suspension, control drop rate is 2mL/min,
It is stirred after being added dropwise to complete and is placed in insulation reaction 2h, standing at 57 DEG C and is cooled to room temperature, with 5% hydroxide of mass fraction
Sodium solution adjusts pH to 10.5, still aging and filter, and collects filter residue and is simultaneously rinsed 4 times with absolute ethyl alcohol, vacuum freeze drying obtains
Dried powder；It counts in parts by weight, weighs 47 parts of deionized waters, 12 parts of chitosans, 7 parts of dried powders and 30 parts of dispersion pulps respectively
Liquid is placed in mortar, and grinding distribution is placed in Ultrasonic spraying device, and adjusting pressure is 4MPa, and nozzle is with holder distance
4cm is sprayed into 316L stainless steel stent tube chamber layer surfaces, and the high-compatibility coating bracket material can be prepared by standing solidification
Material.
Example 3
In mass ratio 1:5,5% bovine serum albumin liquid of mass fraction is added in absolute ethyl alcohol, after being stirred 3h, is collected
Colloidal solution is placed in the bag filter of 14000 molecular weight, and bag filter is placed in deionized water, stands dialysis treatment 35h, is collected
Obtain dialyzate and in mass ratio 1:5, dialyzate and dried powder are stirred and are placed in mortar, grinding distribution collects score
Dissipate slurries；In mass ratio 1:10, nano-calcium carbonate is added in deionized water, is stirred and ultrasonic disperse obtains suspension simultaneously
In mass ratio 1:8,10% disodium phosphate soln of mass fraction is added dropwise in suspension, control drop rate is 3mL/min,
It is stirred after being added dropwise to complete and is placed in insulation reaction 3h, standing at 65 DEG C and is cooled to room temperature, with 5% hydroxide of mass fraction
Sodium solution adjusts pH to 10.5, still aging and filter, and collects filter residue and is simultaneously rinsed 5 times with absolute ethyl alcohol, vacuum freeze drying obtains
Dried powder；It counts in parts by weight, weighs 50 parts of deionized waters, 15 parts of chitosans, 8 parts of dried powders and 35 parts of dispersion pulps respectively
Liquid is placed in mortar, and grinding distribution is placed in Ultrasonic spraying device, and adjusting pressure is 5MPa, and nozzle is with holder distance
5cm is sprayed into 316L stainless steel stent tube chamber layer surfaces, and the high-compatibility coating bracket material can be prepared by standing solidification
Material.
Example 1,2,3 prepared by the present invention is tested for the property, specific test result is as follows shown in table table 1：
1 performance test table of table
As seen from the above table, the coating bracket material that prepared by the present invention has excellent compatibility performance.
Claims (4)
1. a kind of preparation method of high-compatibility coating bracket material, it is characterised in that specifically preparation process is：
（1）In mass ratio 1:5, bovine serum albumin liquid is added in absolute ethyl alcohol, after being stirred, collects to obtain colloidal solution juxtaposition
In bag filter, bag filter is placed in deionized water, dialysis treatment is stood, collects to obtain dialyzate；
（2）In mass ratio 1:10, nano-calcium carbonate is added in deionized water, is stirred and ultrasonic disperse obtains suspension simultaneously
In mass ratio 1:8, disodium phosphate soln is added dropwise in suspension, simultaneously insulation reaction is stirred after being added dropwise to complete, it is quiet
It sets and is cooled to room temperature, adjust pH to 10.5, it is still aging and filter, it collects filter residue and washs dry dried powder；
（3）In mass ratio 1:5, dialyzate and dried powder are stirred and are placed in mortar, grinding distribution collects to obtain dispersion
Slurries；
（4）It counts in parts by weight, weighs 45~50 parts of deionized waters, 10~15 parts of chitosans and 25~35 parts of dispersion slurries respectively
It is placed in mortar, grinding distribution is placed in Ultrasonic spraying device, and ultrasonic atomizatio handles and is sprayed into 316L stainless steel branch
Frame tube chamber layer surface, the high-compatibility coating bracket material can be prepared by standing solidification.
2. a kind of preparation method of high-compatibility coating bracket material according to claim 1, it is characterised in that：Step
（1）The bag filter is the bag filter of 8000~14000 molecular weight.
3. a kind of preparation method of high-compatibility coating bracket material according to claim 1, it is characterised in that：Step
（2）The disodium phosphate soln drop rate is 2~3mL/min.
4. a kind of preparation method of high-compatibility coating bracket material according to claim 1, it is characterised in that：Step
（4）The ultrasonic atomizatio processing is 3~5MPa not adjust pressure, and nozzle is 3~5cm, spray treatment with holder distance.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810514700.0A CN108404226A (en) | 2018-05-25 | 2018-05-25 | A kind of preparation method of high-compatibility coating bracket material |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810514700.0A CN108404226A (en) | 2018-05-25 | 2018-05-25 | A kind of preparation method of high-compatibility coating bracket material |
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| Publication Number | Publication Date |
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| CN108404226A true CN108404226A (en) | 2018-08-17 |
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| CN201810514700.0A Withdrawn CN108404226A (en) | 2018-05-25 | 2018-05-25 | A kind of preparation method of high-compatibility coating bracket material |
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008077248A1 (en) * | 2006-12-22 | 2008-07-03 | Miv Therapeutics Inc. | Coatings for implantable medical devices for liposome delivery |
| JP2009067669A (en) * | 2007-08-20 | 2009-04-02 | Council Of Scientific & Industrial Research | Process for preparation of protein mediated calcium hydroxyapatite (hap) coating on metal substrate |
| CN101703798A (en) * | 2009-11-05 | 2010-05-12 | 上海纳米技术及应用国家工程研究中心有限公司 | Nano hydroxyapatite coating and preparation method thereof and electrostatic atomization device |
| CN101829358A (en) * | 2010-03-31 | 2010-09-15 | 苏州普霖生物科技有限公司 | Preparation method of calcium phosphate ceramics/chitosan-hydroxyapatite composite coating porous material |
| CN103705324A (en) * | 2013-12-31 | 2014-04-09 | 先健科技(深圳)有限公司 | Blood vessel coating support and preparation method for blood vessel coating support |
| CN104524647A (en) * | 2014-12-30 | 2015-04-22 | 马艳荣 | Biodegradable polymer coating drug-loaded magnesium alloy-eluting stent |
| CN105862095A (en) * | 2016-06-02 | 2016-08-17 | 中南大学 | Bioactive coating and preparation method thereof |
-
2018
- 2018-05-25 CN CN201810514700.0A patent/CN108404226A/en not_active Withdrawn
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008077248A1 (en) * | 2006-12-22 | 2008-07-03 | Miv Therapeutics Inc. | Coatings for implantable medical devices for liposome delivery |
| JP2009067669A (en) * | 2007-08-20 | 2009-04-02 | Council Of Scientific & Industrial Research | Process for preparation of protein mediated calcium hydroxyapatite (hap) coating on metal substrate |
| CN101703798A (en) * | 2009-11-05 | 2010-05-12 | 上海纳米技术及应用国家工程研究中心有限公司 | Nano hydroxyapatite coating and preparation method thereof and electrostatic atomization device |
| CN101829358A (en) * | 2010-03-31 | 2010-09-15 | 苏州普霖生物科技有限公司 | Preparation method of calcium phosphate ceramics/chitosan-hydroxyapatite composite coating porous material |
| CN103705324A (en) * | 2013-12-31 | 2014-04-09 | 先健科技(深圳)有限公司 | Blood vessel coating support and preparation method for blood vessel coating support |
| CN104524647A (en) * | 2014-12-30 | 2015-04-22 | 马艳荣 | Biodegradable polymer coating drug-loaded magnesium alloy-eluting stent |
| CN105862095A (en) * | 2016-06-02 | 2016-08-17 | 中南大学 | Bioactive coating and preparation method thereof |
Non-Patent Citations (4)
| Title |
|---|
| V. WAGENER等: "Protein-adsorption and Ca-phosphate formation on chitosan-bioactive glass composite coatings", 《APPLIED SURFACE SCIENCE》 * |
| 杨辉等: "多孔球形羟基磷灰石生物材料的制备", 《硅酸盐学报》 * |
| 王国卿等: "微弧氧化法制备钛基 HA/CS 涂层及其生物学特性", 《稀有金属材料与工程》 * |
| 褚振华等: "Ti合金表面沉积羟基磷灰石-牛血清蛋白生物活性涂层", 《功能材料》 * |
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Application publication date: 20180817 |
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