CN108403722A - It is a kind of using yellow blood height oily silkworm as the preparation method of the silkworm powder of raw material - Google Patents
It is a kind of using yellow blood height oily silkworm as the preparation method of the silkworm powder of raw material Download PDFInfo
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- CN108403722A CN108403722A CN201810249160.8A CN201810249160A CN108403722A CN 108403722 A CN108403722 A CN 108403722A CN 201810249160 A CN201810249160 A CN 201810249160A CN 108403722 A CN108403722 A CN 108403722A
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Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/033—Rearing or breeding invertebrates; New breeds of invertebrates
- A01K67/04—Silkworms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Environmental Sciences (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Insects & Arthropods (AREA)
- Epidemiology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of using yellow blood height oily silkworm as the preparation method of the silkworm powder of raw material, includes the following steps：After silkworm room, rearing instrument and mulberry field are carried out disinfection with the Dioxygen difluoride of 100~200mg/L, chooses yellow blood height oily silkworm and raised, the high mulberry leaf of 1 1-Deoxynojirimycin content of feeding to the 3rd day 4 ages, starvation makes it empty excrement for 12 hours；Choose the almost the same healthy silkworm of size, remove silkworm faeces sundries, with 20~200mg/L chlorine dioxide impregnate 5~after ten minutes, washing, dry body surface moisture, 20 DEG C of low temperature pre-freezes 12 hours or more, it after vacuum freeze drying to dry weight and fresh weight of plant seedlings ratio about 15%, is crushed in the environment of 5~0 DEG C of low temperature nitrogen charging, crosses 200 mesh or more and sieve, the silkworm powder of gained is subjected to radioactivity irradiation sterilization, is stored at a temperature of being packaged and placed on 20~4 DEG C.The present invention is the raw material for preparing silkworm powder using yellow blood height oily silkworm, can significantly reduce the content of lithate in product.
Description
Technical field
The present invention relates to drug preparation fields, and in particular to a kind of using yellow blood height oily silkworm as the preparation of the silkworm powder of raw material
Method.
Background technology
Sericulture is the great invention of Chinese nation ancients.Found that silk as weaving dress ornament material before more than 5000 years
The utility value of material, and the greatness for creating silk industry is brilliant, forms long-term monopoly position in world markets.With
Multi-functional utilize of the transition in epoch, silkworm is being risen.Production biological product more higher than silk added value, excavates silkworm
Potentiality are improved the quality of life of the mankind using its nutrition and functional activity substance, and are increased farmers' income with this, it has also become popular
Research topic.Wherein, silkworm larva is direction more outstanding in the utilization of hypoglycemic aspect.Asia state including South Korea
In family, the silkworm powder prepared by silkworm five-age larva is favored by diabetic for a long time.
Diabetes are a kind of genetic diseases of complexity, become in the world after tumour, cardiovascular disease the 3rd it is tight
The disease of human health is endangered again, and has the tendency that extension and rejuvenation.According to the research report of International Diabetes Federation (IDF)
Announcement is pointed out, 2.46 hundred million maturity-onset diabetes patients are had more than in worldwide, it is contemplated that by 2025, this number was possible to be changed
It is written as 3.80 hundred million.3 countries are India, China and the U.S. respectively before diabetes prevalence.Diabetes and its complication are controlled,
It has to strictly control the blood glucose level in human body.At present clinically, the control of type-1 diabetes mellitus is based on insulin injection, II
The control of patients with type Ⅰ DM is also required to insulin injection based on oral drugs when effect is bad.But side effects of pharmaceutical drugs and must
Palpus medication throughout one's life influences the quality of life of patient, using the hypoglycemic harm that can cause hypoglycemia of drug or insulin strengthening, and
And research finds have a small number of type 2 diabetes patients that allergic reaction can occur using insulin, especially animal insulin allergy is anti-
Answer incidence height.People are also seeking other treatment means in recent years, to improve the quality of life of diabetic, wherein utilizing
It is a good example that silkworm powder (SP), which inhibits type-2 diabetes mellitus,.
In recent years, there is a large amount of research to confirm both at home and abroad, have with the silkworm powder that silkworm, tussah or oily silkworm larva make aobvious
The hypoglycemic effect of work.China since 2000, is ground by the research of the hypoglycemic or other drug action of silkworm powder so far
Send out Zhenjiang silkworm powder, the hypoglycemic capsule of silkworm powder (for clinical test), antihypelipidemic preparation QHL3 (silkworm powder), golden silkworm treasured, Ningxia
Silkworm powder, the snow products such as silkworm capsule, and published thesis nearly 50, content be concentrated mainly on silkworm powder composition measurement, animal experiment,
Clinical research, processing technology etc..
Silkworm powder be a kind of high protein, low fat, it is nontoxic, rationally enriched without allergy, nutritional ingredient, and there is good drop
Sugar, lipid-loweringing enhance immune function, the good merchantable brand of medicine-food two-purpose.And the blood sugar decreasing effect of silkworm powder is influenced by many factors, it is domestic
Outer scholar has been carried out this some significant explorations.It was found that its hypoglycemic mechanism is mainly by inhibiting α-sugar on mucous membrane of small intestine
The activity of glycosides enzyme (monosaccharide is changed into small enteral disaccharides and plays catalytic action), to delay blood or organize the suction to glucose
It receives, reduces or delay the speed that maltose and glucose are decomposed to realize.Research shows that the activity of α-maltoside enzyme
Inhibiting rate reaches 41.22%, reaches 46.33% to the maximum inhibition of α glucuroides, to cellobiase and galactase
Vigor be 0.This acting on the time for glycosidase of inhibition shows as temporary, further pharmacokinetic study table
Bright, body is constant to the absorption total amount of glucose, that is, blood glucose value reduces rapidly after the 30min that ingests, and gradually restores to inhale after 60min
It receives, the later stage, which absorbs, accelerates.
At present it has been investigated that it is 1-DNJ (1- that silkworm powder, which inhibits the principle active component of blood glucose value,
Deoxynojiri-mycin, DNJ) and flavone compound].The research of Asano etc. has shown that in silkworm powder except the 1- deoxidations contained
Nojirimycin is other than main active blood sugar-lowering substances, also includes other about 4 kinds of hypoglycemic substances.DNJ chemistry it is entitled (2R,
3R, 4R, 5s) -2- (methylol -3,4,5- trihydroxies) pyridine, be it is a kind of cannot be in the azasugar of body metabolism.To inducing glycosuria
The test mice of disease continuously adds food after the DNJ extracted in silkworm powder, and the 4th day starts, and the blood glucose value of mouse reduces 47.1%
Left and right declined 51.6% to the 11st day blood glucose value, and stopped within the 12nd~14 day after adding food DNJ, and the blood sugar concentration of mouse is then restored
To original state.Studies have shown that the blood sugar decreasing effect of the DNJ extracted from silkworm powder is no less than Remedies for diabetes Ah Ka
Wave sugar (acarbose).Recent study finds that DNJ and its derivative as efficient glycosidase inhibitor, can be used as control sugar
The drug of numerous diseases such as urine disease, virus infection, metastases and lysosome storage disorder, with the 7, mulberry of August part in plant
Leaf content highest is one of the pest-resistant substance generated in plant.Silkworm itself cannot generate DNJ, but be the family eaten with mulberry leaf
Rearing instrument has the function being enriched with to DNJ in mulberry leaf, with the DNJ content highests in the 3rd day 5 ages blood.In addition, different cultivars, difference
DNJ contents are variant in the silkworm powder of the silkworm of method for breeding and distinct methods processing.
Flavone compound is with α-chromone in a series of structures for basic parent nucleus, and 2 phenyl ring (A- and B- rings) pass through
The compound that central three carbon keys are connected with each other.In addition to inhibiting on mucous membrane of small intestine other than alpha-glucosidase activity, flavone compound can also
By removing machine interior free yl, anti peroxidation of lipid and promotion insulin B cells secrete insulin, to play reduction glycosuria
(machine interior free yl is increased has close relationship, model induced by alloxan glycosuria to the blood glucose level of patient with blood glucose value raising
The mechanism of disease is exactly to generate OH-, 0+2 free radical in body internal oxidition using it, to cause cell membrane to generate lipid peroxidation
Act on and insulin receptor made to destroy or reduce), and the effects that prevent complication from occurring.Flavone compound or one kind are effectively
Aldose reductase inhibitor, diabetic's polyalcohols metabolic pathway, capilary and abnormal hemodynamics can be effectively improved
Restore nerve conduction with the shortage of neurotrophic factor, prevents the protein abnormal permeation in retinal tissue, mitigate glomerulus
The expansion of parteriole keeps glomerular filtration functional rehabilitation normal, to prevent and delay diabetic keratopathy lesion and complication.This
Outside, flavone compound has the effects that antiallergy, anti-inflammatory, antibacterial, anti-mutation, antitumor, liver protection, estrogen-like simultaneously, very
It is mostly used as food additives or nutritional supplement in foreign countries, and has been developed into improvement insulin resistance, hypertension and hyperlipemia, has controlled
Treat the drug of diabetes.Jin Jie's etc. studies have shown that silkworm larva body is rich in flavone compound, and with the increase of age
And increase, and reached highest with the 3rd day 5 ages, up to 11.107~27.705mg/g.
In addition, secondary strive etc. in osmanthus uses RLA analytic approach, Preliminary detection is found, contains triiodo thryonine in silkworm powder
(T3), content 0.913ng/g, and thyroxine (T4) is not detected, and point out other approach such as thyroid hormone analogs
T3 isoreactivities substance may play a role to insulin level and its receptor.In addition, some scholars propose protein and peptide, steroid
The substances such as race's hormone, sbombycin, moulting hormone may all have the function of adjusting blood glucose in various degree.With different growth and development ranks
Section and various dose grub freeze-drying powder carry out mouse test the result shows that, in feed add 3 days 500mg/kg5 ages larva freeze
Dry powder is reduced the most pronounced effects of mouse blood sugar, and the freeze-dried powder prepared with the 3rd day larva of 5 ages gone on a hunger strike for 24 hours, drops blood
Sugared effect becomes apparent from, and compared with control group diabetic mice, the blood glucose value of test group mouse reduces 26%.Utilize full silkworm
The extract of powder (the 3rd day 5 ages grub freeze-drying powder, the same below) carries out enzymatic assay, the results showed that it can inhibit alpha-glucosaccharase
The activity of enzyme and prevent steeply rising for postprandial blood sugar.Silkworm powder inhibits glycolytic pharmacy principle in animal body to be identified,
So the postprandial best results for taking silkworm powder at once.To 3 parts of mouse small intestine point of feeding silkworm powder and carbohydrate
The inhibitory activity for carrying out absorption mode and alpha-glucosidase compares, it is known that certain ingredients are to small intestine first half α-in silkworm powder
The inhibitory activity of glucuroide is most strong, more arrives that its inhibitory activity of end is lower, and small intestine is also more to the absorption of carbohydrate.
It can be seen that the use of silkworm powder can prevent steeply rising for postprandial blood sugar, and preventing hunger and hypoglycemia on an empty stomach
Aspect is also effective.Though by inhibiting alpha-glucosidase to have thermal loss adjusting blood glucose or generating gas in the intestine, do not have
There is big side effect.
However common silkworm larva body wall contains a large amount of urate crystal, there is the possibility for inducing gout, is poorly suitable for straight
Connect utilization.
Invention content
To solve the above problems, the present invention provides a kind of using yellow blood height oily silkworm as the preparation side of the silkworm powder of raw material
Method is the raw material for preparing silkworm powder using yellow blood height oily silkworm, significantly reduces the content of lithate in product.
To achieve the above object, the technical solution that the present invention takes is：
It is a kind of using yellow blood height oily silkworm as the preparation method of the silkworm powder of raw material, include the following steps：
S1, after silkworm room, rearing instrument and mulberry field are carried out disinfection with the chlorine dioxide of 100~200mg/L, yellow blood height oil is chosen
Silkworm is raised, and the high mulberry leaf of feeding 1-DNJ content to the 3rd day 4 ages, starvation makes it empty excrement for 12 hours；
S2, the almost the same healthy silkworm of size is chosen, removes silkworm faeces sundries, impregnate 5 with the chlorine dioxide of 20~200mg/L
~after ten minutes, body surface moisture is dried in washing, and -20 DEG C of low temperature pre-freezes 12 hours or more are placed on the cold of vacuum freeze drier
In well, it is evacuated to 0.035Pa, and dries 36 hours with up to dry weight and fresh weight of plant seedlings ratio about 15% or so；
S3, the raw material after vacuum drying is crushed in the environment of -5~0 DEG C of low temperature nitrogen charging, it is (thinner crosses 200 mesh or more
It is better) sieve, obtain silkworm powder；The silkworm powder of gained is subjected to radioactivity irradiation sterilization, is packaged and placed at a temperature of -20~4 DEG C
Storage.
The present invention is the raw material for preparing silkworm powder using yellow blood height oily silkworm, and yellow blood height oily silkworm deoxidation containing 1- open country buttocks is mould
Element, carotenoid are higher than white blood silkworm content, and lithate is lower than common silkworm content, and the silkworm powder effect of preparation is more preferable, and side effect is more
It is low.
Specific implementation mode
In order to make objects and advantages of the present invention be more clearly understood, the present invention is carried out with reference to embodiments further
It is described in detail.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not used to limit this hair
It is bright.
Embodiment 1
It is a kind of using yellow blood height oily silkworm as the preparation method of the silkworm powder of raw material, include the following steps：
S1, after silkworm room, rearing instrument and mulberry field are carried out disinfection with the chlorine dioxide of 100~200mg/L, yellow blood height oil is chosen
Silkworm is raised, and feeding " new one rapids " mulberry leaf to the 3rd day 4 ages, starvation makes it empty excrement for 12 hours；
S2, the almost the same healthy silkworm of size is chosen, removes silkworm faeces sundries, impregnate 5 with the chlorine dioxide of 20~200mg/L
~after ten minutes, body surface moisture is dried in washing, and -20 DEG C of low temperature pre-freezes 12 hours or more are placed on the cold of vacuum freeze drier
In well, it is evacuated to 0.035Pa, and dries 36 hours with up to dry weight and fresh weight of plant seedlings ratio about 15% or so；
S3, the raw material after vacuum drying is crushed in the environment of -5~0 DEG C of low temperature nitrogen charging, crosses 200 mesh or more and sieve, obtains
Silkworm powder；The silkworm powder of gained is subjected to radioactivity irradiation sterilization, is stored at a temperature of being packaged and placed on -20~4 DEG C.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, without departing from the principle of the present invention, it can also make several improvements and retouch, these improvements and modifications are also answered
It is considered as protection scope of the present invention.
Claims (1)
1. a kind of using yellow blood height oily silkworm as the preparation method of the silkworm powder of raw material, which is characterized in that include the following steps：
S1, after silkworm room, rearing instrument and mulberry field are carried out disinfection with the chlorine dioxide of 100~200mg/L, choose yellow blood height oily silkworm into
Row raising, the high mulberry leaf of feeding 1-DNJ content to the 3rd day 4 ages, starvation make it empty excrement for 12 hours；
S2, the almost the same healthy silkworm of size is chosen, removes silkworm faeces sundries, impregnate 5~10 with the chlorine dioxide of 20~200mg/L
After minute, body surface moisture is dried in washing, and -20 DEG C of low temperature pre-freezes 12 hours or more are placed on the cold well of vacuum freeze drier
In, it is evacuated to 0.035Pa, and dry 36 hours with up to dry weight and fresh weight of plant seedlings ratio about 15%；
S3, the raw material after vacuum drying is crushed in the environment of -5~0 DEG C of low temperature nitrogen charging, crosses 200 mesh or more and sieve, obtains full silkworm
Powder；The silkworm powder of gained is subjected to radioactivity irradiation sterilization, is stored at a temperature of being packaged and placed on -20~4 DEG C.
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| CN201810249160.8A CN108403722A (en) | 2018-03-13 | 2018-03-13 | It is a kind of using yellow blood height oily silkworm as the preparation method of the silkworm powder of raw material |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1535620A (en) * | 2003-04-08 | 2004-10-13 | 上海梅山生物技术有限责任公司 | Preparation method of silkworm powder health-care food |
| CN101199553A (en) * | 2007-12-11 | 2008-06-18 | 徐先旭 | Preparing method for treating diabetes whole silkworm powder |
-
2018
- 2018-03-13 CN CN201810249160.8A patent/CN108403722A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1535620A (en) * | 2003-04-08 | 2004-10-13 | 上海梅山生物技术有限责任公司 | Preparation method of silkworm powder health-care food |
| CN101199553A (en) * | 2007-12-11 | 2008-06-18 | 徐先旭 | Preparing method for treating diabetes whole silkworm powder |
Non-Patent Citations (1)
| Title |
|---|
| 何行健等: ""全蚕粉用黄血高度油蚕品种的选育初报"", 《中国蚕业》 * |
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Application publication date: 20180817 |