CN108392679B - Method for antibacterial modification of surface of implant material - Google Patents
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
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- A—HUMAN NECESSITIES
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
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Abstract
The invention discloses an antibacterial modification method for the surface of an implant material, which takes solid zinc oxide as a raw material and modifies the surfaces of metal implant materials (titanium, tantalum, cobalt, chromium and molybdenum) and polymer implant materials (silica gel, polyurethane, polyether ether ketone and polylactic acid) represented by cardiac pacemakers through simple steps. It has the following remarkable advantages: 1. the first proposed two-step method for preparing the solid zinc oxide coating is different from the traditional single-layer material surface coating, has more excellent and lasting antibacterial performance, and can realize long-acting antibacterial. 2. The preparation method is simple and can be widely applied to clinic.
Description
Technical Field
The invention relates to the field of biological materials and multifunctional nano materials, and mainly relates to a method for antibacterial modification of surfaces of implant materials such as cardiac pacemakers and the like.
Background
Due to aging population, sports injury, medical technology improvement and the like, various implantation operation cases increase year by year. However, with the increasing frequency of clinical use of implant materials, the risk of increased postoperative infection cases is also hidden. The infection related to the implanted material is a catastrophic complication of the implantation operation, and is also one of the main reasons for the failure of the implantation operation and even medical disputes. Among them, the infection of an implantation instrument (material) represented by a cardiac pacemaker is a typical example, and the infected patient suffers great economic loss and physical pain when the device is taken out; sometimes even with life risks. However, most of the currently widely used implant materials do not have sufficient antibacterial performance, so that certain surface modification is necessary to improve the antibacterial performance, thereby effectively reducing the infection rate related to the implant materials.
Currently, there is a method to reduce the probability of infection of a pacemaker implant: the pacemaker is wrapped by an absorbable capsule, and the antibiotic is released into the capsule in a certain mode, so that the infection can be prevented within one week. Considering the high manufacturing cost, the product can be selectively used in susceptible people. However, this approach still requires the use of a dose of antibiotic and therefore raises a series of problems such as bacterial resistance. Compared with the traditional antibiotics, the inorganic nano material has the advantages of high antibacterial performance, large surface area, low dosage, good biocompatibility and the like, and is the only nano material which can be applied in vivo through FDA authentication at present, especially the small-size antibacterial material based on zinc oxide. In addition, the synthesis conditions and steps of the zinc oxide are relatively simple, the cost is low, and the zinc oxide can be widely applied to clinic.
Disclosure of Invention
The invention aims to provide a method for modifying zinc oxide on the surface of an implant material, which helps the implant material to remarkably improve long-acting antibacterial effect, thereby reducing the related infection rate of the implant material.
The technical scheme adopted by the invention is as follows:
a method for the surface antibacterial modification of an implant material comprises the following steps:
(1) slowly adding 100ml of 0.03M sodium hydroxide methanol solution into 100ml of 0.01M zinc acetate methanol solution, heating to 60 ℃, and stirring for 2 hours;
(2) repeatedly and uniformly coating the solution prepared in the step (1) on the surface of the material by using a spin coating method, and calcining at 150 ℃ to ensure that solid particles are attached to the surface of the material;
(3) immersing the material prepared in the step (2) in 100ml of mixed solution containing 0.025M zinc nitrate hydrate and 0.025M hexamethylene imine, heating to 90 ℃, and reacting for 0.5-6 h;
(4) after the reaction in the step (3) is finished, naturally cooling the solution to room temperature, then taking out the material, washing with deionized water, and naturally drying;
(5) dissolving 80mM ammonia water, 50mM zinc oxide hydrate and 25mM hexamethylenetetramine in a beaker filled with 100mL deionized water, and stirring for 10min to ensure that a solute is completely dissolved;
(6) sealing the beaker in the step (5) by using tin foil paper, heating to 65 ℃, and reacting for 15 min; continuously heating to 85 ℃, opening the tin foil paper, fully reacting for 10min, sealing again, reacting for 2h, and cooling to room temperature after complete reaction;
(7) taking the solution prepared in the step (6) according to the ratio of 100 mu L/cm2Uniformly dripping the solution on the surface of the material prepared in the step (4), and naturally drying.
The invention takes solid inorganic nano material as basic antibacterial material, and modifies the material on the surface of implant material (including common implant metal materials such as titanium, tantalum, cobalt, chromium and molybdenum, polyurethane, silica gel, polyether ether ketone and polylactic acid high molecular material) by simple steps. The invention has a double-stage release characteristic, which is specifically represented by a short-term (48h) burst release characteristic and a long-term (2 weeks) sustained release characteristic, and in-vitro experimental data suggest that the bacteriostasis rate within 2 weeks can exceed 90%, and the invention has great significance for reducing the related infection of the implant.
Drawings
FIG. 1 is a scanning electron microscope image of a solid zinc oxide material nanorod (comparative example 1).
Fig. 2 is a scanning electron microscope image of solid zinc oxide material nanosheets (comparative example 2).
Fig. 3 is a scanning electron microscope image of solid zinc oxide material nanorod-nanoplate (example 1).
Fig. 4 is the release profile of solid nanorod-nanosheet modification on titanium and tantalum metal surfaces in buffer. FIG. 5 is an in vitro antibacterial experiment in which solid nanorods/nanoplates/nanorods-nanoplates are respectively modified on the surface of titanium or tantalum.
A represents the antibacterial rate of the solid nanorod/nanosheet/nanorod-nanosheet after being respectively modified on the surfaces of titanium and tantalum metal and after escherichia coli is cultured for 8 hours;
b represents the antibacterial rate of the solid nanorod/nanosheet/nanorod-nanosheet after being respectively modified on the surfaces of titanium and tantalum metal and after escherichia coli is cultured for 24 hours;
c represents the antibacterial rate of the solid nanorod/nanosheet/nanorod-nanosheet after being respectively modified on the surfaces of titanium and tantalum metal and subjected to ultrasonic treatment and escherichia coli culture for 48 hours;
d represents the antibacterial rate of the solid nanorod/nanosheet/nanorod-nanosheet after being respectively modified on the surfaces of titanium and tantalum metal and after staphylococcus aureus is cultured for 8 hours;
e represents the antibacterial rate of the solid nanorod/nanosheet/nanorod-nanosheet after being respectively modified on the surfaces of titanium and tantalum metal and after staphylococcus aureus is cultured for 24 hours;
f represents the antibacterial rate of the solid nanorod/nanosheet/nanorod-nanosheet after being respectively modified on the surfaces of titanium and tantalum metal and subjected to ultrasonic treatment and staphylococcus aureus culture for 48 hours.
"US" stands for ultrasound, which is a material simulating the state (titanium/tantalum) of a surface-modified material after long-term implantation in vivo, "e.coli" stands for escherichia coli, "s.aureus" stands for staphylococcus aureus, "Ti" stands for titanium metal, "Ta" stands for tantalum metal, "Nanorods" stands for solid zinc oxide Nanorods, "Nanoslices" stands for solid zinc oxide nanoplatelets, "Nanorods-Nanoslices" stands for solid zinc oxide nanorod-nanoplatelets.
Detailed Description
The present invention will be described in further detail with reference to the following examples and drawings, but it should be understood that the scope of the present invention is not limited to these examples.
Example 1: a method for the surface antibacterial modification of an implant material comprises the following steps:
(1) slowly adding 100ml of 0.03M sodium hydroxide methanol solution into 100ml of 0.01M zinc acetate methanol solution, heating to 60 ℃, and stirring for 2 hours;
(2) repeatedly and uniformly coating the solution prepared in the step (1) on the surface of a metallic titanium material by using a spin coating method, and calcining at 150 ℃ to ensure that solid particles are attached to the surface of the material;
(3) immersing the material prepared in the step (2) in 100mL of mixed solution containing 0.025M zinc nitrate hydrate and 0.025M hexamethylene diamine, heating to 90 ℃, and reacting for 0.5-6 h;
(4) after the reaction in the step (3) is finished, naturally cooling the solution to room temperature, then taking out the material, washing with deionized water, and naturally drying;
(5) dissolving 80mM ammonia water, 50mM zinc oxide hydrate and 25mM hexamethylenetetramine in a beaker filled with 100mL deionized water, and stirring for 10min to ensure that a solute is completely dissolved;
(6) sealing the beaker in the step (5) by using tin foil paper, heating to 65 ℃, and reacting for 15 min; continuously heating to 85 ℃, opening the tin foil paper, fully reacting for 10min, sealing again, reacting for 2h, and cooling to room temperature after complete reaction;
(7) taking the solution prepared in the step (6) according to the ratio of 100 mu L/cm2Uniformly dripping the solution on the surface of the material prepared in the step (4), and naturally drying.
Example 2: a method for the surface antibacterial modification of an implant material comprises the following steps:
(1) slowly adding 100ml of 0.03M sodium hydroxide methanol solution into 100ml of 0.01M zinc acetate methanol solution, heating to 60 ℃, and stirring for 2 hours;
(2) repeatedly and uniformly coating the solution prepared in the step (1) on the surface of the high molecular polyurethane material by using a spin coating method, and calcining at 150 ℃ to ensure that solid particles are attached to the surface of the material;
(3) immersing the material prepared in the step (2) in 100mL of mixed solution containing 0.025M zinc nitrate hydrate and 0.025M hexamethylene diamine, heating to 90 ℃, and reacting for 0.5-6 h;
(4) after the reaction in the step (3) is finished, naturally cooling the solution to room temperature, then taking out the material, washing with deionized water, and naturally drying;
(5) dissolving 80mM ammonia water, 50mM zinc oxide hydrate and 25mM hexamethylenetetramine in a beaker filled with 100mL deionized water, and stirring for 10min to ensure that a solute is completely dissolved;
(6) sealing the beaker in the step (5) by using tin foil paper, heating to 65 ℃, and reacting for 15 min; continuously heating to 85 ℃, opening the tin foil paper, fully reacting for 10min, sealing again, reacting for 2h, and cooling to room temperature after complete reaction;
(7) taking the solution prepared in the step (6) according to the ratio of 100 mu L/cm2Uniformly dripping the solution on the surface of the material prepared in the step (4), and naturally drying.
Example 3: a method for the surface antibacterial modification of an implant material comprises the following steps:
(1) slowly adding 100ml of 0.03M sodium hydroxide methanol solution into 100ml of 0.01M zinc acetate methanol solution, heating to 60 ℃, and stirring for 2 hours;
(2) repeatedly and uniformly coating the solution prepared in the step (1) on the surface of a metal tantalum material by using a spin coating method, and calcining at 150 ℃ to ensure that solid particles are attached to the surface of the material;
(3) immersing the material prepared in the step (2) in 100mL of mixed solution containing 0.025M zinc nitrate hydrate and 0.025M hexamethylene diamine, heating to 90 ℃, and reacting for 0.5-6 h;
(4) after the reaction in the step (3) is finished, naturally cooling the solution to room temperature, then taking out the material, washing with deionized water, and naturally drying;
(5) dissolving 80mM ammonia water, 50mM zinc oxide hydrate and 25mM hexamethylenetetramine in a beaker filled with 100mL deionized water, and stirring for 10min to ensure that a solute is completely dissolved;
(6) sealing the beaker in the step (5) by using tin foil paper, heating to 65 ℃, and reacting for 15 min; continuously heating to 85 ℃, opening the tin foil paper, fully reacting for 10min, sealing again, reacting for 2h, and cooling to room temperature after complete reaction;
(7) taking the solution prepared in the step (6) according to the ratio of 100 mu L/cm2Uniformly dripping the solution on the surface of the material prepared in the step (4), and naturally drying.
Comparative example 1: a method for the surface antibacterial modification of an implant material comprises the following steps:
(1) slowly adding 100ml of 0.03M sodium hydroxide methanol solution into 100ml of 0.01M zinc acetate methanol solution, heating to 60 ℃, and stirring for 2 hours;
(2) repeatedly and uniformly coating the solution prepared in the step (1) on the surface of the material by using a spin coating method, and calcining at 150 ℃ to ensure that solid particles are attached to the surface of the material;
(3) immersing the material prepared in the step (2) in a mixed solution of 100mL0.025M zinc nitrate hydrate and 0.025M hexamethylene imine, heating to 90 ℃, and reacting for 0.5-6 h;
(4) and (4) after the reaction in the step (3) is finished, naturally cooling the solution to room temperature, taking out the material, washing with deionized water, and naturally drying.
Comparative example 2: a method for the surface antibacterial modification of an implant material comprises the following steps:
(1) dissolving 80mM ammonia water, 50mM zinc oxide hydrate and 25mM hexamethylenetetramine in a beaker filled with 100mL deionized water, and stirring for 10min to ensure that a solute is completely dissolved;
(2) sealing the beaker in the step (1) by using tin foil paper, heating to 65 ℃, and reacting for 15 min; continuously heating to 85 ℃, opening the tin foil paper, fully reacting for 10min, sealing again and reacting for 2h, and cooling to room temperature after the solution completely reacts;
(3) taking the solution prepared in the step (2) according to the ratio of 100 mu L/cm2The dosage of the active components is uniformly dropped on the surface of the material and naturally dried.
Claims (2)
1. A method for the surface antibacterial modification of an implant material is characterized by comprising the following steps: the method comprises the following steps:
(1) slowly adding 100ml of 0.03M sodium hydroxide methanol solution into 100ml of 0.01M zinc acetate methanol solution, heating to 60 ℃, and stirring for 2 hours;
(2) repeatedly and uniformly coating the solution prepared in the step (1) on the surface of the material by using a spin coating method, and calcining at 150 ℃ to ensure that solid particles are attached to the surface of the material;
(3) immersing the material prepared in the step (2) in 100ml of mixed solution containing 0.025M zinc nitrate hydrate and 0.025M hexamethylene imine, heating to 90 ℃, and reacting for 0.5-6 h;
(4) after the reaction in the step (3) is finished, naturally cooling the solution to room temperature, then taking out the material, washing with deionized water, and naturally drying;
(5) dissolving 80mM ammonia water, 50mM zinc oxide hydrate and 25mM hexamethylenetetramine in a beaker filled with 100mL deionized water, and stirring for 10min to ensure that a solute is completely dissolved;
(6) sealing the beaker in the step (5) by using tin foil paper, heating to 65 ℃, and reacting for 15 min; continuously heating to 85 ℃, opening the tin foil paper, fully reacting for 10min, sealing again, reacting for 2h, and cooling to room temperature after complete reaction;
(7) taking the solution prepared in the step (6) according to the ratio of 100 mu L/cm2Uniformly dripping the solution on the surface of the material prepared in the step (4), and naturally drying.
2. A method for the surface antibacterial modification of an implant material is characterized by comprising the following steps: the method comprises the following steps:
(1) slowly adding 100ml of 0.03M sodium hydroxide methanol solution into 100ml of 0.01M zinc acetate methanol solution, heating to 60 ℃, and stirring for 2 hours;
(2) repeatedly and uniformly coating the solution prepared in the step (1) on the surface of a metallic titanium material by using a spin coating method, and calcining at 150 ℃ to ensure that solid particles are attached to the surface of the material;
(3) immersing the material prepared in the step (2) in 100ml of mixed solution containing 0.025M zinc nitrate hydrate and 0.025M hexamethylene imine, heating to 90 ℃, and reacting for 0.5-6 h;
(4) after the reaction in the step (3) is finished, naturally cooling the solution to room temperature, then taking out the material, washing with deionized water, and naturally drying;
(5) dissolving 80mM ammonia water, 50mM zinc oxide hydrate and 25mM hexamethylenetetramine in a beaker filled with 100mL deionized water, and stirring for 10min to ensure that a solute is completely dissolved;
(6) sealing the beaker in the step (5) by using tin foil paper, heating to 65 ℃, and reacting for 15 min; continuously heating to 85 ℃, opening the tin foil paper, fully reacting for 10min, sealing again, reacting for 2h, and cooling to room temperature after complete reaction;
(7) taking the solution prepared in the step (6) according to the ratio of 100 mu L/cm2Uniformly dripping the solution on the surface of the material prepared in the step (4), and naturally drying.
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| CN111646495A (en) * | 2020-06-24 | 2020-09-11 | 南昌大学 | Double-light response type zinc oxide, preparation method thereof and photosensitive coating with antibacterial osteogenesis property |
| CN112853328B (en) * | 2021-01-05 | 2022-05-10 | 中国科学院上海硅酸盐研究所 | Iron ion modified zinc oxide antibacterial coating for surface of implant and preparation method thereof |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19915378A1 (en) * | 1999-04-06 | 2000-10-12 | Inst Neue Mat Gemein Gmbh | Household appliances with a catalytic composition |
| CN102531034A (en) * | 2011-12-16 | 2012-07-04 | 天津大学 | Method for preparing zinc oxide nano sheet array |
| CN102898921A (en) * | 2012-10-25 | 2013-01-30 | 陕西科技大学 | Preparation method of antibacterial leather coating material |
| CN103481345A (en) * | 2013-09-22 | 2014-01-01 | 东北林业大学 | Microwave hydro-thermal synthesis method of zinc oxide nanostructure modified timber |
| CN105417574A (en) * | 2014-09-05 | 2016-03-23 | 天津工业大学 | Preparation method of three-dimensional layered porous zinc oxide microspheres assembled from nano-sheets |
| CN106142243A (en) * | 2016-07-05 | 2016-11-23 | 国际竹藤中心 | A kind of antimicrobial form bamboo composite and preparation method |
| CN106860911A (en) * | 2017-03-16 | 2017-06-20 | 湖北大学 | A kind of surface of metal titanium antimicrobial composite coating and preparation method thereof |
-
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- 2018-01-16 CN CN201810039391.6A patent/CN108392679B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19915378A1 (en) * | 1999-04-06 | 2000-10-12 | Inst Neue Mat Gemein Gmbh | Household appliances with a catalytic composition |
| CN102531034A (en) * | 2011-12-16 | 2012-07-04 | 天津大学 | Method for preparing zinc oxide nano sheet array |
| CN102898921A (en) * | 2012-10-25 | 2013-01-30 | 陕西科技大学 | Preparation method of antibacterial leather coating material |
| CN103481345A (en) * | 2013-09-22 | 2014-01-01 | 东北林业大学 | Microwave hydro-thermal synthesis method of zinc oxide nanostructure modified timber |
| CN105417574A (en) * | 2014-09-05 | 2016-03-23 | 天津工业大学 | Preparation method of three-dimensional layered porous zinc oxide microspheres assembled from nano-sheets |
| CN106142243A (en) * | 2016-07-05 | 2016-11-23 | 国际竹藤中心 | A kind of antimicrobial form bamboo composite and preparation method |
| CN106860911A (en) * | 2017-03-16 | 2017-06-20 | 湖北大学 | A kind of surface of metal titanium antimicrobial composite coating and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 《氧化锌纳米棒阵列涂层的制备及其抗菌性能研究》;张恋等;《武汉工程大学学报》;20160630;第38卷(第3期);第236-239页 * |
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