CN108384164A - A kind of preparation method and applications of medical compound package material - Google Patents
A kind of preparation method and applications of medical compound package material Download PDFInfo
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- CN108384164A CN108384164A CN201810173478.2A CN201810173478A CN108384164A CN 108384164 A CN108384164 A CN 108384164A CN 201810173478 A CN201810173478 A CN 201810173478A CN 108384164 A CN108384164 A CN 108384164A
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L31/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an acyloxy radical of a saturated carboxylic acid, of carbonic acid or of a haloformic acid; Compositions of derivatives of such polymers
- C08L31/02—Homopolymers or copolymers of esters of monocarboxylic acids
- C08L31/04—Homopolymers or copolymers of vinyl acetate
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/38—Boron-containing compounds
- C08K2003/387—Borates
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2205/00—Polymer mixtures characterised by other features
- C08L2205/02—Polymer mixtures characterised by other features containing two or more polymers of the same C08L -group
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2205/00—Polymer mixtures characterised by other features
- C08L2205/03—Polymer mixtures characterised by other features containing three or more polymers in a blend
- C08L2205/035—Polymer mixtures characterised by other features containing three or more polymers in a blend containing four or more polymers in a blend
Abstract
The invention discloses a kind of preparation method and applications of medical compound package material, this method is used polyvinyl acetate, coconut oil fatty acid monoethanolamide input reaction kettle high temperature stirs to get primary mix, again with polyglycereol ricinoleate ester, polyethylene glycol (PEG) oleate is added to addition absolute ethyl alcohol in ultrasonic dispersers and is ultrasonically treated jointly, heating and thermal insulation, obtain sub-mixtures, then by boric acid zinc modification, finally sub-mixtures and boric acid modification zinc are put into reaction kettle jointly, nitrile rubber and 2 mercapto benzimidazoles are added, high-temperature stirring under conditions of inert gas shielding, then cools down and toughener and stabilizer is added, stir to get ultimate mixture, then it is sent to twin (double) screw extruder and carries out melt extruded, segmentation, packaging, sterilizing, finished composite material is obtained after cooling.The medical compound package material being prepared, its own high mechanical strength, tolerable steam sterilizing, has a good application prospect on medical device package.
Description
Technical field
The present invention relates to medical material tech fields, and in particular to a kind of preparation method of medical compound package material and its
Using.
Background technology
The guarantee that medical device package material patient obtains medical treatment under the environment of safety can effectively avoid treating
Cheng Zaocheng inside-hospital infections.Common medical device package material should sealed reliable, can be used for sterilizing, be provided simultaneously with resistance bacterium
Property.Currently, common medical device package material is Corvic on the market, it is excellent due to its preferable biocompatibility
Good biologically inert, antibacterial ability and high transparency and good mechanical property, in addition its cheap cost, polyvinyl chloride tree
Fat material occupies the main market share in medical material market.However due to the fault of construction of Corvic, molecule
Chlorine atom in structure is easy to be influenced by external condition, and HCl molecules are easily removed under the conditions of high temperature and inferior illumination,
So as to form double bond structure, and the HCl molecules removed can be catalyzed the thermal decomposition effect of polyvinyl chloride in turn, and aggravation is formed
Double bond structure, and the presence of double bond structure lead to problems such as the performance of material decline, change colour.In addition polychlorostyrene second above-mentioned
Alkene molecule exists due to the chlorine atom of high level so that rigidity is presented with certain polarity, molecular structure in it at normal temperatures
State is not easy activity, the characteristics of to show brittle, poor toughness, limits further applying for polyvinyl chloride.
Invention content
In order to solve the above technical problems, the present invention provides a kind of preparation method and applications of medical compound package material,
This method is used stirs to get primary mixing by polyvinyl acetate, coconut oil fatty acid monoethanolamide input reaction kettle high temperature
Object, then be added to jointly in ultrasonic dispersers with polyglycereol ricinoleate ester, polyethylene glycol (PEG) oleate and add absolute ethyl alcohol progress
It is ultrasonically treated, heating and thermal insulation, sub-mixtures is obtained, then by boric acid zinc modification, finally by sub-mixtures and boric acid modification
Zinc is put into reaction kettle jointly, and nitrile rubber and 2- mercapto benzimidazoles, high temperature under conditions of inert gas shielding is added
Stirring, then cools down and toughener and stabilizer is added, stir to get ultimate mixture, be then sent to twin (double) screw extruder
Melt extruded, segmentation, packaging, sterilizing are carried out, finished composite material is obtained after cooling.The medical composite packaging material being prepared
Material, its own high mechanical strength, tolerable steam sterilizing, has a good application prospect on medical device package.
The purpose of the present invention can be achieved through the following technical solutions：
A kind of preparation method of medical compound package material, includes the following steps：
It (1), will be anti-by in 25-35 parts of 55-65 parts of polyvinyl acetate, coconut oil fatty acid monoethanolamide input reaction kettles
It answers kettle temperature degree to be increased to 100-110 DEG C, is stirred the mixture for equal by mechanical agitation under 150-200 revs/min of rate
It is even, obtain primary mix；
(2) primary mix for obtaining step (1) and 16-20 parts of polyglycereol ricinoleate ester, polyethylene glycol (PEG) oleate
10-15 parts are added in ultrasonic dispersers jointly, the absolute ethyl alcohol of 2 times of quality of mixture are added, then with 0.1mol/L's
HCl solution adjusts pH to 5.0, is ultrasonically treated, and will then be ultrasonically treated mixture and is heated to 90-100 DEG C, keeps the temperature 90-120
Minute, obtain sub-mixtures；
(3) 6-8 parts of zinc borate is dried under the conditions of 80-90 DEG C, drying time is 6-8 hours, will then be dried
Product is cooled to room temperature, then 12-18 parts of epoxidized soybean oil is added into desciccate after cooling, is placed in homogenizer,
It is stirred 20-30 minutes with 800-1200 revs/min of speed, then stops stirring, a concentration of 4% permanganic acid is added dropwise thereto
1-2 parts of potassium solution continues stirring 20-30 minutes, obtains boric acid modification zinc after being added dropwise to complete；
(4) sub-mixtures that step (2) obtains and the boric acid modification zinc that step (3) obtains are put into reaction kettle jointly
In, 6-10 parts of nitrile rubber, 4-6 parts of 2- mercapto benzimidazoles is added, it will be in reaction kettle under conditions of inert gas shielding
Temperature is warming up to 160-180 DEG C, and pyroreaction 3-4 hours under agitation, reactor temperature is then down to 75-85
DEG C, 2-4 parts of toughener, 2-4 parts of stabilizer is added, stirs 30-40 minutes at such a temperature, obtains ultimate mixture；
(5) the ultimate mixture for obtaining step (4) is sent into twin (double) screw extruder and carries out melt extruded, obtains just making compound
Material；
(6) the first composite material processed that step (5) obtains is split, then the material divided is packed, is gone out
Bacterium obtains finished composite material after cooling.
Further, being ultrasonically treated preferably with 40-60 points of the frequency ultrasound of 20-30kHz dispersion in the step (2)
Clock.
Further, the toughener in the step (4) is selected from ethylene-propylene-diene terpolymer, ethylene-vinegar
Any one in sour ethylene copolymer, polyolefin thermoplastic elastomer.
Further, it is different to be selected from 1,1- diisopropoxies trimethylamine, phosphorous acid-benzene two for the stabilizer in the step (4)
Any one in monooctyl ester, calcium stearate.
Further, the draw ratio of twin (double) screw extruder is 40-50 in the step (5):1, each silicon carbide is：First
Section is 160-180 DEG C, and second interval is 180-190 DEG C, and 3rd interval is 195-205 DEG C.
Further, the invention also discloses medical compound package materials made from the preparation method in upper application.
Compared with prior art, the present invention advantage is：
(1) preparation method of medical compound package material of the invention is used polyvinyl acetate, coco-nut oil fatty acid list
Glycollic amide input reaction kettle high temperature stirs to get primary mix, then with polyglycereol ricinoleate ester, polyethylene glycol oleic acid
Ester be added to jointly in ultrasonic dispersers add absolute ethyl alcohol be ultrasonically treated, heating and thermal insulation, obtain sub-mixtures, then
By boric acid zinc modification, finally sub-mixtures and boric acid modification zinc are put into reaction kettle jointly, nitrile rubber and 2- sulphur is added
Alcohol radical benzimidazole, high-temperature stirring under conditions of inert gas shielding then cool down and toughener and stabilizer are added, stirring
Ultimate mixture is obtained, twin (double) screw extruder is then sent to and carries out melt extruded, segmentation, packaging, sterilizing, obtained after cooling
Finished composite material.The medical compound package material being prepared, its own high mechanical strength, tolerable steam sterilizing, is being cured
It treats and has a good application prospect in instrument packaging.
(2) present invention employs coconut oil fatty acid monoethanolamide, polyglycereol ricinoleate ester, polyethylene glycol oleic acid
Ester, the participation of boric acid modification zinc these types raw material prepare medical compound package material, have been carried out effectively to medical compound package material
Performance boost, although these materials are not first Application in medical compound package material, amount combination according to a certain ratio
Afterwards, it is aided with corresponding processing mode, is brought in performance substantially to the medical compound package material being finally prepared
Degree improves, this is never to report in previous research, for realizing that it is conclusive that the technique effect of the present invention plays
Effect.
Specific implementation mode
The technical solution of invention is described in detail with reference to specific embodiment.
Embodiment 1
(1) by 25 parts of 55 parts of polyvinyl acetate, coconut oil fatty acid monoethanolamide input reaction kettles, kettle temperature will be reacted
Degree is increased to 100 DEG C, is stirred the mixture for uniform by mechanical agitation under 150 revs/min of rate, obtains primary mixing
Object；
(2) primary mix for obtaining step (1) and 16 parts of polyglycereol ricinoleate ester, 10 parts of polyethylene glycol (PEG) oleate
It is added in ultrasonic dispersers jointly, adds the absolute ethyl alcohol of 2 times of quality of mixture, then with the HCl solution of 0.1mol/L
PH to 5.0 is adjusted, is disperseed 40 minutes with the frequency ultrasound of 20kHz, mixture will be then ultrasonically treated and be heated to 90 DEG C, heat preservation 90
Minute, obtain sub-mixtures；
(3) 6 parts of zinc borate is dried under the conditions of 80 DEG C, drying time is 6 hours, then cools down desciccate
To room temperature, then 12 parts of epoxidized soybean oil is added into desciccate after cooling, be placed in homogenizer, with 800 revs/min
Speed stir 20 minutes, then stop stirring, a concentration of 4% 1 part of liquor potassic permanganate is added dropwise thereto, after being added dropwise to complete
Continue stirring 20 minutes, obtains boric acid modification zinc；
(4) sub-mixtures that step (2) obtains and the boric acid modification zinc that step (3) obtains are put into reaction kettle jointly
In, 6 parts of nitrile rubber, 4 parts of 2- mercaptos benzimidazole is added, by reactor temperature liter under conditions of inert gas shielding
For temperature to 160 DEG C, pyroreaction 3 hours, are then down to 75 DEG C by reactor temperature under agitation, and ethylene-propylene-is added
2 parts of butadiene terpolymer, 2 parts of 1,1- diisopropoxies trimethylamine stir 30 minutes, obtain ultimate mixing at such a temperature
Object；
(5) the ultimate mixture for obtaining step (4) is sent into twin (double) screw extruder and carries out melt extruded, twin (double) screw extruder
Draw ratio be 40:1, each silicon carbide is：First interval is 160 DEG C, and second interval is 180 DEG C, and 3rd interval is 195 DEG C,
Obtain just composite material processed；
(6) the first composite material processed that step (5) obtains is split, then the material divided is packed, is gone out
Bacterium obtains finished composite material after cooling.
The performance test results of medical compound package material obtained are as shown in table 1.
Embodiment 2
(1) by 30 parts of 60 parts of polyvinyl acetate, coconut oil fatty acid monoethanolamide input reaction kettles, kettle temperature will be reacted
Degree is increased to 105 DEG C, is stirred the mixture for uniform by mechanical agitation under 175 revs/min of rate, obtains primary mixing
Object；
(2) primary mix for obtaining step (1) and 18 parts of polyglycereol ricinoleate ester, 12 parts of polyethylene glycol (PEG) oleate
It is added in ultrasonic dispersers jointly, adds the absolute ethyl alcohol of 2 times of quality of mixture, then with the HCl solution of 0.1mol/L
PH to 5.0 is adjusted, is disperseed 50 minutes with the frequency ultrasound of 25kHz, mixture will be then ultrasonically treated and be heated to 95 DEG C, heat preservation
105 minutes, obtain sub-mixtures；
(3) 7 parts of zinc borate is dried under the conditions of 85 DEG C, drying time is 7 hours, then cools down desciccate
To room temperature, then 15 parts of epoxidized soybean oil is added into desciccate after cooling, be placed in homogenizer, with 1000 revs/min
The speed of clock stirs 25 minutes, then stops stirring, a concentration of 4% 1.5 parts of liquor potassic permanganate is added dropwise thereto, drips
Continue stirring 25 minutes after, obtains boric acid modification zinc；
(4) sub-mixtures that step (2) obtains and the boric acid modification zinc that step (3) obtains are put into reaction kettle jointly
In, 8 parts of nitrile rubber, 5 parts of 2- mercaptos benzimidazole is added, by reactor temperature liter under conditions of inert gas shielding
For temperature to 170 DEG C, pyroreaction 3.5 hours, are then down to 80 DEG C by reactor temperature under agitation, and ethylene-vinegar is added
3 parts of sour ethylene copolymer, 3 parts of Phenyl Di-2-ethyl Hexyl Phosphite stir 35 minutes, obtain ultimate mixture at such a temperature；
(5) the ultimate mixture for obtaining step (4) is sent into twin (double) screw extruder and carries out melt extruded, twin (double) screw extruder
Draw ratio be 45:1, each silicon carbide is：First interval is 170 DEG C, and second interval is 185 DEG C, and 3rd interval is 200 DEG C,
Obtain just composite material processed；
(6) the first composite material processed that step (5) obtains is split, then the material divided is packed, is gone out
Bacterium obtains finished composite material after cooling.
The performance test results of medical compound package material obtained are as shown in table 1.
Embodiment 3
(1) by 35 parts of 65 parts of polyvinyl acetate, coconut oil fatty acid monoethanolamide input reaction kettles, kettle temperature will be reacted
Degree is increased to 110 DEG C, is stirred the mixture for uniform by mechanical agitation under 200 revs/min of rate, obtains primary mixing
Object；
(2) primary mix for obtaining step (1) and 20 parts of polyglycereol ricinoleate ester, 15 parts of polyethylene glycol (PEG) oleate
It is added in ultrasonic dispersers jointly, adds the absolute ethyl alcohol of 2 times of quality of mixture, then with the HCl solution of 0.1mol/L
PH to 5.0 is adjusted, is disperseed 60 minutes with the frequency ultrasound of 30kHz, mixture will be then ultrasonically treated and be heated to 100 DEG C, heat preservation
120 minutes, obtain sub-mixtures；
(3) 8 parts of zinc borate is dried under the conditions of 90 DEG C, drying time is 8 hours, then cools down desciccate
To room temperature, then 18 parts of epoxidized soybean oil is added into desciccate after cooling, be placed in homogenizer, with 1200 revs/min
The speed of clock stirs 30 minutes, then stops stirring, a concentration of 4% 2 parts of liquor potassic permanganate is added dropwise thereto, is added dropwise to complete
After continue stirring 30 minutes, obtain boric acid modification zinc；
(4) sub-mixtures that step (2) obtains and the boric acid modification zinc that step (3) obtains are put into reaction kettle jointly
In, 10 parts of nitrile rubber, 6 parts of 2- mercaptos benzimidazole is added, by reactor temperature under conditions of inert gas shielding
180 DEG C are warming up to, under agitation pyroreaction 4 hours, reactor temperature is then down to 85 DEG C, polyolefin heat is added
4 parts of thermoplastic elastic, 4 parts of calcium stearate stir 40 minutes, obtain ultimate mixture at such a temperature；
(5) the ultimate mixture for obtaining step (4) is sent into twin (double) screw extruder and carries out melt extruded, twin (double) screw extruder
Draw ratio be 50:1, each silicon carbide is：First interval is 180 DEG C, and second interval is 190 DEG C, and 3rd interval is 205 DEG C,
Obtain just composite material processed；
(6) the first composite material processed that step (5) obtains is split, then the material divided is packed, is gone out
Bacterium obtains finished composite material after cooling.
The performance test results of medical compound package material obtained are as shown in table 1.
Comparative example 1
(1) by 60 parts of input reaction kettles of polyvinyl acetate, temperature of reaction kettle is increased to 105 DEG C, at 175 revs/min
Rate under mechanical agitation to uniform, obtain primary reaction object；
(2) the primary reaction object for obtaining step (1) and 18 parts of polyglycereol ricinoleate ester, 12 parts of polyethylene glycol (PEG) oleate
It is added in ultrasonic dispersers jointly, adds the absolute ethyl alcohol of 2 times of quality of mixture, then with the HCl solution of 0.1mol/L
PH to 5.0 is adjusted, is disperseed 50 minutes with the frequency ultrasound of 25kHz, mixture will be then ultrasonically treated and be heated to 95 DEG C, heat preservation
105 minutes, obtain sub-mixtures；
(3) 7 parts of zinc borate is dried under the conditions of 85 DEG C, drying time is 7 hours, then cools down desciccate
To room temperature, then 15 parts of epoxidized soybean oil is added into desciccate after cooling, be placed in homogenizer, with 1000 revs/min
The speed of clock stirs 25 minutes, then stops stirring, a concentration of 4% 1.5 parts of liquor potassic permanganate is added dropwise thereto, drips
Continue stirring 25 minutes after, obtains boric acid modification zinc；
(4) sub-mixtures that step (2) obtains and the boric acid modification zinc that step (3) obtains are put into reaction kettle jointly
In, 8 parts of nitrile rubber, 5 parts of 2- mercaptos benzimidazole is added, by reactor temperature liter under conditions of inert gas shielding
For temperature to 170 DEG C, pyroreaction 3.5 hours, are then down to 80 DEG C by reactor temperature under agitation, and ethylene-vinegar is added
3 parts of sour ethylene copolymer, 3 parts of Phenyl Di-2-ethyl Hexyl Phosphite stir 35 minutes, obtain ultimate mixture at such a temperature；
(5) the ultimate mixture for obtaining step (4) is sent into twin (double) screw extruder and carries out melt extruded, twin (double) screw extruder
Draw ratio be 45:1, each silicon carbide is：First interval is 170 DEG C, and second interval is 185 DEG C, and 3rd interval is 200 DEG C,
Obtain just composite material processed；
(6) the first composite material processed that step (5) obtains is split, then the material divided is packed, is gone out
Bacterium obtains finished composite material after cooling.
The performance test results of medical compound package material obtained are as shown in table 1.
Comparative example 2
(1) by 30 parts of 60 parts of polyvinyl acetate, coconut oil fatty acid monoethanolamide input reaction kettles, kettle temperature will be reacted
Degree is increased to 105 DEG C, is stirred the mixture for uniform by mechanical agitation under 175 revs/min of rate, obtains primary mixing
Object；
(2) primary mix that step (1) obtains is added to ultrasonic dispersers jointly with 12 parts of polyethylene glycol (PEG) oleate
In, the absolute ethyl alcohol of 2 times of quality of mixture is added, pH to 5.0 is then adjusted with the HCl solution of 0.1mol/L, with 25kHz's
Frequency ultrasound disperses 50 minutes, will then be ultrasonically treated mixture and is heated to 95 DEG C, keeps the temperature 105 minutes, obtain sub-mixtures；
(3) 7 parts of zinc borate is dried under the conditions of 85 DEG C, drying time is 7 hours, then cools down desciccate
To room temperature, then 15 parts of epoxidized soybean oil is added into desciccate after cooling, be placed in homogenizer, with 1000 revs/min
The speed of clock stirs 25 minutes, then stops stirring, a concentration of 4% 1.5 parts of liquor potassic permanganate is added dropwise thereto, drips
Continue stirring 25 minutes after, obtains boric acid modification zinc；
(4) sub-mixtures that step (2) obtains and the boric acid modification zinc that step (3) obtains are put into reaction kettle jointly
In, 8 parts of nitrile rubber, 5 parts of 2- mercaptos benzimidazole is added, by reactor temperature liter under conditions of inert gas shielding
For temperature to 170 DEG C, pyroreaction 3.5 hours, are then down to 80 DEG C by reactor temperature under agitation, and ethylene-vinegar is added
3 parts of sour ethylene copolymer, 3 parts of Phenyl Di-2-ethyl Hexyl Phosphite stir 35 minutes, obtain ultimate mixture at such a temperature；
(5) the ultimate mixture for obtaining step (4) is sent into twin (double) screw extruder and carries out melt extruded, twin (double) screw extruder
Draw ratio be 45:1, each silicon carbide is：First interval is 170 DEG C, and second interval is 185 DEG C, and 3rd interval is 200 DEG C,
Obtain just composite material processed；
(6) the first composite material processed that step (5) obtains is split, then the material divided is packed, is gone out
Bacterium obtains finished composite material after cooling.
The performance test results of medical compound package material obtained are as shown in table 1.
Comparative example 3
(1) by 30 parts of 60 parts of polyvinyl acetate, coconut oil fatty acid monoethanolamide input reaction kettles, kettle temperature will be reacted
Degree is increased to 105 DEG C, is stirred the mixture for uniform by mechanical agitation under 175 revs/min of rate, obtains primary mixing
Object；
(2) primary mix that step (1) obtains is added to ultrasonic disperse jointly with 18 parts of polyglycereol ricinoleate ester
In device, the absolute ethyl alcohol of 2 times of quality of mixture is added, pH to 5.0 is then adjusted with the HCl solution of 0.1mol/L, with 25kHz
Frequency ultrasound disperse 50 minutes, will then be ultrasonically treated mixture and be heated to 95 DEG C, keep the temperature 105 minutes, obtain secondary mixing
Object；
(3) 7 parts of zinc borate is dried under the conditions of 85 DEG C, drying time is 7 hours, then cools down desciccate
To room temperature, then 15 parts of epoxidized soybean oil is added into desciccate after cooling, be placed in homogenizer, with 1000 revs/min
The speed of clock stirs 25 minutes, then stops stirring, a concentration of 4% 1.5 parts of liquor potassic permanganate is added dropwise thereto, drips
Continue stirring 25 minutes after, obtains boric acid modification zinc；
(4) sub-mixtures that step (2) obtains and the boric acid modification zinc that step (3) obtains are put into reaction kettle jointly
In, 8 parts of nitrile rubber, 5 parts of 2- mercaptos benzimidazole is added, by reactor temperature liter under conditions of inert gas shielding
For temperature to 170 DEG C, pyroreaction 3.5 hours, are then down to 80 DEG C by reactor temperature under agitation, and ethylene-vinegar is added
3 parts of sour ethylene copolymer, 3 parts of Phenyl Di-2-ethyl Hexyl Phosphite stir 35 minutes, obtain ultimate mixture at such a temperature；
(5) the ultimate mixture for obtaining step (4) is sent into twin (double) screw extruder and carries out melt extruded, twin (double) screw extruder
Draw ratio be 45:1, each silicon carbide is：First interval is 170 DEG C, and second interval is 185 DEG C, and 3rd interval is 200 DEG C,
Obtain just composite material processed；
(6) the first composite material processed that step (5) obtains is split, then the material divided is packed, is gone out
Bacterium obtains finished composite material after cooling.
The performance test results of medical compound package material obtained are as shown in table 1.
Comparative example 4
(1) by 30 parts of 60 parts of polyvinyl acetate, coconut oil fatty acid monoethanolamide input reaction kettles, kettle temperature will be reacted
Degree is increased to 105 DEG C, is stirred the mixture for uniform by mechanical agitation under 175 revs/min of rate, obtains primary mixing
Object；
(2) primary mix for obtaining step (1) and 18 parts of polyglycereol ricinoleate ester, 12 parts of polyethylene glycol (PEG) oleate
It is added in ultrasonic dispersers jointly, adds the absolute ethyl alcohol of 2 times of quality of mixture, then with the HCl solution of 0.1mol/L
PH to 5.0 is adjusted, is disperseed 50 minutes with the frequency ultrasound of 25kHz, mixture will be then ultrasonically treated and be heated to 95 DEG C, heat preservation
105 minutes, obtain sub-mixtures；
(3) in the common input reaction kettle of 7 parts of sub-mixtures and zinc borate obtained step (2), nitrile rubber 8 is added
Part, 5 parts of 2- mercaptos benzimidazole, are warming up to 170 DEG C by reactor temperature under conditions of inert gas shielding, are stirring
Under the conditions of pyroreaction 3.5 hours, reactor temperature is then down to 80 DEG C, be added 3 parts of ethylene-vinyl acetate copolymer,
3 parts of Phenyl Di-2-ethyl Hexyl Phosphite stirs 35 minutes, obtains ultimate mixture at such a temperature；
(4) the ultimate mixture for obtaining step (3) is sent into twin (double) screw extruder and carries out melt extruded, twin (double) screw extruder
Draw ratio be 45:1, each silicon carbide is：First interval is 170 DEG C, and second interval is 185 DEG C, and 3rd interval is 200 DEG C,
Obtain just composite material processed；
(5) the first composite material processed that step (4) obtains is split, then the material divided is packed, is gone out
Bacterium obtains finished composite material after cooling.
The performance test results of medical compound package material obtained are as shown in table 1.
Medical compound package material made from embodiment 1-3 and comparative example 1-4 is subjected to tensile strength (GB/T respectively
1040), elongation at break (GB/T 1040), anti-vapor permeability (GB/T10010) this several performance tests.
Table 1
| Tensile strength (MPa) | Elongation at break (%) | Resist vapor permeability (%) | |
| Embodiment 1 | 18.9 | 363 | 2.3 |
| Embodiment 2 | 19.1 | 378 | 2.4 |
| Embodiment 3 | 18.8 | 370 | 2.2 |
| Comparative example 1 | 16.4 | 350 | 3.6 |
| Comparative example 2 | 17.3 | 339 | 3.0 |
| Comparative example 3 | 17.6 | 348 | 2.7 |
| Comparative example 4 | 18.5 | 325 | 2.9 |
The preparation method of the medical compound package material of the present invention is used polyvinyl acetate, coco-nut oil fatty acid monoethanol
Amide input reaction kettle high temperature stirs to get primary mix, then total with polyglycereol ricinoleate ester, polyethylene glycol (PEG) oleate
Be added in ultrasonic dispersers add absolute ethyl alcohol be ultrasonically treated, heating and thermal insulation, sub-mixtures are obtained, then by boron
Sour zinc modification finally puts into sub-mixtures and boric acid modification zinc in reaction kettle jointly, and nitrile rubber and 2- mercaptos is added
Benzimidazole, high-temperature stirring under conditions of inert gas shielding then cool down and toughener and stabilizer are added, stir to get
Ultimate mixture is then sent to twin (double) screw extruder and carries out melt extruded, segmentation, packaging, sterilizing, finished product is obtained after cooling
Composite material.The medical compound package material being prepared, its own high mechanical strength, tolerable steam sterilizing, in Medical treatment device
It has a good application prospect in tool packaging.Also, present invention employs coconut oil fatty acid monoethanolamide, polyglycereol castor-oil plants
Oleate, polyethylene glycol (PEG) oleate, the participation of boric acid modification zinc these types raw material prepare medical compound package material, to medical compound
Packaging material has carried out effective performance boost, although these materials are not first Application in medical compound package material,
According to a certain ratio after amount combination, it is aided with corresponding processing mode, is brought to the medical compound package material being finally prepared
Increasing substantially in performance, this is never to report in previous research, for realizing the technology of the present invention
Effect plays the role of conclusive.
Example the above is only the implementation of the present invention is not intended to limit the scope of the invention, every to utilize this hair
Equivalent structure or equivalent flow shift made by bright description is applied directly or indirectly in other relevant technology necks
Domain is included within the scope of the present invention.
Claims (6)
1. a kind of preparation method of medical compound package material, which is characterized in that include the following steps：
(1) by 25-35 parts of 55-65 parts of polyvinyl acetate, coconut oil fatty acid monoethanolamide input reaction kettles, by reaction kettle
Temperature is increased to 100-110 DEG C, is stirred the mixture for uniform, is obtained by mechanical agitation under 150-200 revs/min of rate
To primary mix；
(2) primary mix for obtaining step (1) and 16-20 parts of polyglycereol ricinoleate ester, polyethylene glycol (PEG) oleate 10-15
Part is added in ultrasonic dispersers jointly, adds the absolute ethyl alcohol of 2 times of quality of mixture, then molten with the HCl of 0.1mol/L
Liquid adjusts pH to 5.0, is ultrasonically treated, and will then be ultrasonically treated mixture and is heated to 90-100 DEG C, keeps the temperature 90-120 minutes,
Obtain sub-mixtures；
(3) 6-8 parts of zinc borate is dried under the conditions of 80-90 DEG C, drying time is 6-8 hours, then by desciccate
It is cooled to room temperature, then adds 12-18 parts of epoxidized soybean oil into desciccate after cooling, be placed in homogenizer, with
800-1200 revs/min of speed stirs 20-30 minutes, then stops stirring, a concentration of 4% potassium permanganate is added dropwise thereto
1-2 parts of solution continues stirring 20-30 minutes, obtains boric acid modification zinc after being added dropwise to complete；
(4) sub-mixtures that step (2) obtains and the boric acid modification zinc that step (3) obtains are put into reaction kettle jointly, is added
Enter 6-10 parts of nitrile rubber, 4-6 parts of 2- mercapto benzimidazoles, by reactor temperature liter under conditions of inert gas shielding
Temperature is to 160-180 DEG C, pyroreaction 3-4 hours under agitation, and reactor temperature is then down to 75-85 DEG C, is added
2-4 parts of toughener, 2-4 parts of stabilizer stir 30-40 minutes, obtain ultimate mixture at such a temperature；
(5) the ultimate mixture for obtaining step (4) is sent into twin (double) screw extruder and carries out melt extruded, obtains just composite wood processed
Material；
(6) the first composite material processed that step (5) obtains is split, then the material divided is packed, is sterilized, it is cold
But finished composite material is obtained afterwards.
2. the preparation method of medical compound package material according to claim 1, which is characterized in that in the step (2)
Be ultrasonically treated preferably with the frequency ultrasound of 20-30kHz disperse 40-60 minutes.
3. the preparation method of medical compound package material according to claim 1, which is characterized in that in the step (4)
Toughener be selected from ethylene-propylene-diene terpolymer, ethylene-vinyl acetate copolymer, polyolefin thermoplastic elastomer
In any one.
4. the preparation method of medical compound package material according to claim 1, which is characterized in that in the step (4)
Any one in 1,1- diisopropoxies trimethylamine, Phenyl Di-2-ethyl Hexyl Phosphite, calcium stearate of stabilizer.
5. the preparation method of medical compound package material according to claim 1, which is characterized in that in the step (5)
The draw ratio of twin (double) screw extruder is 40-50:1, each silicon carbide is：First interval is 160-180 DEG C, second interval 180-
190 DEG C, 3rd interval is 195-205 DEG C.
6. according to medical compound package material made from any one of the claim 1-5 preparation methods on medical device package
Application.
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| CN201810173478.2A CN108384164A (en) | 2018-03-02 | 2018-03-02 | A kind of preparation method and applications of medical compound package material |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1974635A (en) * | 2005-11-26 | 2007-06-06 | 兰爱克谢斯德国有限责任公司 | New polymer concentrates with improved processability |
| CN103724732A (en) * | 2013-01-25 | 2014-04-16 | 周良文 | Environment-friendly NBR (Nitrile Butadiene Rubber) rubber and plastic thermal insulation material |
| CN103910913A (en) * | 2013-01-08 | 2014-07-09 | 周良文 | Environment-friendly rubber plastic heat-insulating material and its preparation method |
| CN106009447A (en) * | 2016-07-07 | 2016-10-12 | 中广核三角洲（苏州）高聚物有限公司 | Irradiation crosslinking low-temperature-resistant flexible oil-resistant halogen-free flame-retardant cable material for locomotive cables at 125 DEG C |
-
2018
- 2018-03-02 CN CN201810173478.2A patent/CN108384164A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1974635A (en) * | 2005-11-26 | 2007-06-06 | 兰爱克谢斯德国有限责任公司 | New polymer concentrates with improved processability |
| CN103910913A (en) * | 2013-01-08 | 2014-07-09 | 周良文 | Environment-friendly rubber plastic heat-insulating material and its preparation method |
| CN103724732A (en) * | 2013-01-25 | 2014-04-16 | 周良文 | Environment-friendly NBR (Nitrile Butadiene Rubber) rubber and plastic thermal insulation material |
| CN106009447A (en) * | 2016-07-07 | 2016-10-12 | 中广核三角洲（苏州）高聚物有限公司 | Irradiation crosslinking low-temperature-resistant flexible oil-resistant halogen-free flame-retardant cable material for locomotive cables at 125 DEG C |
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