CN108382035B - Five-layer co-extrusion film for transfusion and preparation process thereof - Google Patents
Five-layer co-extrusion film for transfusion and preparation process thereof Download PDFInfo
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/06—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material
- B32B27/08—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
- B29C48/001—Combinations of extrusion moulding with other shaping operations
- B29C48/0018—Combinations of extrusion moulding with other shaping operations combined with shaping by orienting, stretching or shrinking, e.g. film blowing
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
- B29C48/03—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor characterised by the shape of the extruded material at extrusion
- B29C48/09—Articles with cross-sections having partially or fully enclosed cavities, e.g. pipes or channels
- B29C48/10—Articles with cross-sections having partially or fully enclosed cavities, e.g. pipes or channels flexible, e.g. blown foils
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
- B29C48/16—Articles comprising two or more components, e.g. co-extruded layers
- B29C48/18—Articles comprising two or more components, e.g. co-extruded layers the components being layers
- B29C48/21—Articles comprising two or more components, e.g. co-extruded layers the components being layers the layers being joined at their surfaces
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/30—Layered products comprising a layer of synthetic resin comprising vinyl (co)polymers; comprising acrylic (co)polymers
- B32B27/304—Layered products comprising a layer of synthetic resin comprising vinyl (co)polymers; comprising acrylic (co)polymers comprising vinyl halide (co)polymers, e.g. PVC, PVDC, PVF, PVDF
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/32—Layered products comprising a layer of synthetic resin comprising polyolefins
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
- B29L2009/00—Layered products
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
- B29L2023/00—Tubular articles
- B29L2023/001—Tubular films, sleeves
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2307/00—Properties of the layers or laminate
- B32B2307/30—Properties of the layers or laminate having particular thermal properties
- B32B2307/306—Resistant to heat
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2307/00—Properties of the layers or laminate
- B32B2307/40—Properties of the layers or laminate having particular optical properties
- B32B2307/412—Transparent
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B2439/00—Containers; Receptacles
- B32B2439/80—Medical packaging
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- Engineering & Computer Science (AREA)
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Abstract
The invention relates to a five-layer co-extrusion film for transfusion and a preparation process thereof. The outer layer is composed of homopolymerized polypropylene and styrene-ethylene-butadiene hydrogenation block copolymer. The secondary outer layer is composed of ethylene methyl acrylate copolymer and modified linear low-density polyethylene. The middle layer is composed of ethylene-octene copolymer and modified linear low density polyethylene. The secondary inner layer is composed of metallocene low-density polyethylene and linear low-density polyethylene. The inner layer is composed of ethylene-propylene copolymer and styrene-ethylene-butadiene hydrogenation block copolymer. The preparation process comprises the following steps: and respectively sucking the raw materials of each layer into the hoppers of the extruders, filtering impurities through a filter screen after plasticizing, respectively extruding the raw materials through a connecting pipeline and a die head, and laminating the raw materials together at a die head to form a blank. And (5) cooling the blank by primary air, and cooling the blank by water-ring water to obtain a product with high transparency. The invention not only ensures the light transmittance, low-temperature heat sealability, heat seal strength, printability, 121 ℃ cooking resistance and other properties of the film.
Description
Technical Field
The invention relates to a film for packaging intravenous infusion medicines, in particular to a five-layer co-extrusion film for infusion and a preparation process thereof.
Background
The prior widely applied transfusion packages are glass bottles and hard plastic bottles, which have a weakness that an air loop needs to be formed in the using process, thereby increasing the secondary pollution in the transfusion process, and particularly being used in places with more bacteria and poorer sanitary conditions in hospitals. The PVC transfusion soft bag can press the liquid medicine to drip out by means of self tension in the using process, so that the probability of secondary pollution of the liquid medicine is greatly reduced, but the defect is that the plasticizer contained in the PVC transfusion soft bag is a harmful substance and seriously harms human health, and the registration of a PVC transfusion bag is stopped by the national food and drug administration as early as 9 months in 2000. In recent years, non-PVC multilayer co-extruded films are commonly used for transfusion products in developed countries.
The non-PVC multilayer co-extruded film has the following characteristics: (1) the compatibility is that the material used by the non-PVC multilayer co-extrusion film is an inert material, the drug compatibility is good, and the drug pollution caused by the precipitation of a small molecular auxiliary agent is avoided; (2) the safety is high, the non-PVC multi-layer co-extrusion film material has excellent flexibility, and air can be prevented from permeating; the non-PVC multilayer co-extrusion film material has excellent light transmittance, and is beneficial to detecting visible foreign matters in the medicine; the non-PVC multilayer co-extrusion film material has excellent low-temperature resistance, can meet low-temperature transportation and is not easy to damage; the non-PVC multilayer co-extrusion film material has excellent sterilization adaptability and can meet the requirement of high-temperature sterilization at 121 ℃. The above properties constitute the safety of the whole medication. (3) Environmental protection, and the non-PVC multi-layer co-extrusion film material is mostly degradable material and has no pollution to the environment.
The non-PVC multilayer co-extrusion transfusion film on the market at present is commonly a three-layer co-extrusion transfusion film and a five-layer co-extrusion transfusion film, wherein the three-layer co-extrusion transfusion film has low cost and high strength, but has poor flexibility and is easy to become brittle, and particularly easily causes leakage under the low-temperature condition; the five-layer co-extrusion transfusion film has good flexibility and barrier property, can be used under various conditions, but has high requirements on equipment and high cost for an outer-layer polyester material.
Therefore, the film provided by the invention has the advantages of five-layer co-extrusion transfusion films and three-layer co-extrusion transfusion films, and meets the performance requirements of intravenous transfusion packaging materials.
Disclosure of Invention
Aiming at the problems, the invention provides a five-layer co-extrusion film for transfusion and a preparation process thereof. The film has the advantages of no toxicity, good printing performance, boiling resistance, high light transmittance, high heat-sealing strength, good flexibility and the like.
The five-layer co-extrusion transfusion film disclosed by the invention is a five-layer co-extrusion film, and comprises the following components from the outer layer to the inner layer: the outer layer is composed of homopolymerized polypropylene and styrene-ethylene-butadiene hydrogenation block copolymer;
the secondary outer layer is composed of ethylene methyl acrylate copolymer and modified linear low-density polyethylene;
the middle layer is composed of ethylene-octene copolymer and modified linear low-density polyethylene;
the secondary inner layer is composed of metallocene low-density polyethylene and linear low-density polyethylene;
the inner layer is composed of ethylene-propylene copolymer and styrene-ethylene-butadiene hydrogenation block copolymer.
The outer layer is composed of the following raw materials in percentage by mass: 80-95% of homopolymerized polypropylene and 5-20% of styrene-ethylene-butadiene hydrogenated block copolymer, wherein the thickness is 20-30 mu m;
the secondary outer layer is composed of the following raw materials in percentage by mass: 70-95% of ethylene methyl acrylate copolymer and 5-30% of modified linear low density polyethylene, wherein the thickness is 10-20 μm;
the middle layer is composed of the following raw materials in percentage by mass: 60-80% of ethylene-octene copolymer and 20-40% of modified linear low density polyethylene, wherein the thickness is 120-140 mu m;
the secondary inner layer is composed of the following raw materials in percentage by mass: 50-90% of metallocene low-density polyethylene and 10-50% of linear low-density polyethylene, wherein the thickness is 10-20 mu m;
the inner layer is composed of the following raw materials in percentage by mass: 70-90% of ethylene-propylene copolymer and 10-30% of styrene-ethylene-butadiene hydrogenated block copolymer, and the thickness is 20-40 μm.
The homo-polypropylene used for the outer layer of the five-layer co-extrusion transfusion film has a melting point of 155-175 ℃ and a density of 0.87-0.92 g/cm3The melt index is 4.0-9.0 g/10 min. A hydrogenated styrene-ethylene-butadiene block copolymer having a density of 0.87 to 0.92g/cm3Melting ofThe index is 2.0-5.0 g/10 min. The main function of this layer is to provide weatherability, barrier properties and heat resistance during high temperature sterilization and heat sealing of the bag.
The ethylene methyl acrylate copolymer used for the secondary outer layer of the five-layer co-extrusion transfusion film has a melting point of 80-100 ℃ and a density of 0.9-1.1 g/cm3The melt index is 2-10 g/10 min. The modified linear low-density polyethylene has a melting point of 100-130 ℃ and a density of 0.9-0.92 g/cm3The melt index is 0.5 to 3g/10 min. The main function of this layer is adhesion intermediate level and outer effect.
The ethylene-octene copolymer used in the middle layer of the five-layer co-extrusion transfusion film has a melting point of 90-120 ℃ and a density of 0.89-0.92 g/cm3The melt index is 0.5 to 1.5g/10 min. The modified linear low-density polyethylene has a melting point of 100-130 ℃ and a density of 0.9-0.92 g/cm3The melt index is 0.5 to 3g/10 min. The main functions of the layer are barrier property, flexibility, good transparency and good low-temperature performance.
The metallocene low-density polyethylene used for the five-layer co-extrusion transfusion film secondary inner layer has a melting point of 60-120 ℃ and a density of 0.85-0.94 g/cm3The melt index is 0.5 to 3.0g/10 min. Linear low density polyethylene with melting point of 100-130 deg.C and density of 0.9-0.92 g/cm3The melt index is 0.5 to 3g/10 min. The layer mainly plays a role in adhering the inner layer and the middle layer.
The ethylene-propylene copolymer used in the five-layer co-extrusion film inner layer for transfusion has a melting point of 120-145 ℃ and a density of 0.85-0.93 g/cm3The melt index is 0.5 to 3.0g/10 min. A hydrogenated styrene-ethylene-butadiene block copolymer having a density of 0.87 to 0.92g/cm3The melt index is 2.0-5.0 g/10 min. The main functions of the layer are to improve good drug compatibility, low suction, low adsorption and a wider sealing temperature range.
The total thickness of the five-layer co-extrusion film is 160-220 mu m.
The invention also provides a preparation process of the five-layer co-extruded film, which comprises the following steps:
step SO1, respectively sucking the raw materials of each layer into each extruder hopper, feeding the raw materials by a hopper feeding screw according to the preset mass percentage, conveying the plastic particles to a mixing hopper, mixing, then feeding the mixture into each heating section of the extruder, and melting and plasticizing the plastic particles by controlling the heating temperature of each section of the extruder to respectively obtain a molten mixture;
and SO2, filtering impurities from the fully plasticized mixture through a filter screen, extruding the mixture through a connecting pipeline and a die head respectively, controlling the rotating speed of an extruder respectively, and laminating the five layers together at a die head to form a five-layer co-extruded film blank.
Further, in step SO1, the heating temperature in the zone of the outer layer extruder 9 is respectively: 30-60 ℃, 160-190 ℃, 170-200 ℃, 190-220 ℃, 200-230 ℃, 200-235 ℃ and 200-235 ℃.
Further, in step SO1, the heating temperatures in the zone of the secondary outer layer extruder 9 are respectively: 30-60 ℃, 100-150 ℃, 130-180 ℃, 190-220 ℃, 200-230 ℃, 200-235 ℃ and 200-235 ℃.
Further, in step SO1, the heating temperatures in the zone of the middle layer extruder 8 are respectively: 30-60 ℃, 100-150 ℃, 130-180 ℃, 170-220 ℃, 200-230 ℃, 200-235 ℃ and 200-235 ℃.
Further, in step SO1, the heating temperatures in the zone of the secondary inner layer extruder 9 are respectively: 30-60 ℃, 100-150 ℃, 130-180 ℃, 190-220 ℃, 200-230 ℃, 200-235 ℃ and 200-235 ℃.
Further, in step SO1, the heating temperatures in the zone of the inner layer extruder 9 are respectively: 30-60 ℃, 100-150 ℃, 130-180 ℃, 190-220 ℃, 200-230 ℃, 200-235 ℃ and 200-235 ℃.
Further, the step SO2 specifically includes the step of respectively controlling the rotation speed of the extruder: an outer layer extruder: 25-40 rpm, secondary outer layer extruder: 30-50 rpm, middle layer extruder: 45-75 rpm, secondary inner layer extruder: 40-70 r/min, inner layer extruder: 30-60 rpm.
Further, the raw materials in the step SO2 are extruded by a screw of an extruder, and then are redistributed and extruded by a die head, and then are extruded by the die head to form lower blown film bubbles by clean wind, wherein the blow-up ratio is 1.5-3, the blowing pressure is 0.4-0.8 MPa, the cooling water temperature is 10-35 ℃, and the flow rate is 1500-4000L/h. The film bubble is cooled by clean air and purified water, is clamped flat by a herringbone clamping plate and then enters a winding machine for winding.
Compared with the prior multilayer co-extrusion transfusion film, the invention has the beneficial effects that:
(1) the invention continues the flexibility and the self-shrinking property of the PVC transfusion soft bag, avoids secondary pollution and overcomes the hidden health trouble of people caused by a PVC plasticizer.
(2) The inner layer material has low absorption, low adsorption, wide drug compatibility and wider sealing temperature range. Is suitable for 50-5000 ml transfusion packages.
(3) Compared with a three-layer co-extrusion transfusion film, the five-layer co-extrusion transfusion film has better flexibility, and has good flexibility, puncture resistance and impact resistance even in an environment below 0 ℃.
(4) Compared with the traditional five-layer co-extrusion transfusion film, the five-layer co-extrusion transfusion film has better mechanical strength and lower cost.
(5) The five-layer co-extrusion transfusion film adopts a five-layer structure, the middle layer adopts the ethylene-octene copolymer and the outer layer adopts the homopolymerized polypropylene, so that the transfusion film has more excellent barrier property of oxygen, nitrogen and water vapor than other five-layer co-extrusion transfusion films.
(6) The high temperature sterilization temperature can reach 121 ℃, 30min, and no deformation is caused.
Drawings
Fig. 1 is a schematic structural view of the present invention.
Detailed Description
As shown in FIG. 1, the distribution of the layers of the five-layer coextruded film of the invention is shown. As shown in figure 1, the five-layer co-extruded film comprises an outer layer, a secondary outer layer, a middle layer, a secondary inner layer and an inner layer from the structural composition.
The total thickness of the five-layer co-extruded film is 160-220 mu m.
The outer layer is prepared from the following raw materials in percentage by mass: 80% of homopolymerized polypropylene and 20% of styrene-ethylene-butadiene hydrogenated block copolymer; wherein the melt flow rate of the homopolymerized polypropylene at 230 ℃/2.16Kg is 7.0g/10min according to GB-T3682; the styrene-ethylene-butadiene hydrogenated block copolymer had a melt flow rate of 3.0g/10min at 230 ℃/2.16Kg measured according to GB-T3682; the thickness is 20-30 μm;
the secondary outer layer is prepared from the following raw materials in percentage by mass: 90% of ethylene methyl acrylate copolymer and 10% of modified linear low-density polyethylene; wherein the ethylene methyl acrylate copolymer has a melt flow rate of 3.0g/10min at 190 ℃/2.16Kg as measured according to GB-T3682; the modified linear low density polyethylene has a melt flow rate of 2.5g/10min at 190 ℃/2.16Kg measured according to GB-T3682; the thickness is 10-20 μm;
the intermediate layer is prepared from the following raw materials in percentage by mass: 80% of ethylene-octene copolymer and 20% of modified linear low density polyethylene; wherein the ethylene-octene copolymer has a melt flow rate of 3.0g/10min at 190 ℃/2.16Kg measured according to GB-T3682; the modified linear low density polyethylene has a melt flow rate of 2.5g/10min at 190 ℃/2.16Kg measured according to GB-T3682; the thickness is 100 to 140 μm;
the preparation of the secondary inner layer comprises the following raw materials in percentage by mass: 90% of metallocene low-density polyethylene and 10% of linear low-density polyethylene; wherein the metallocene low density polyethylene has a melt flow rate of 2.0g/10min at 190 ℃/2.16Kg measured according to GB-T3682; the linear low density polyethylene has a melt flow rate of 1.5g/10min at 190 ℃/2.16Kg measured according to GB-T3682; the thickness is 10-20 μm;
the inner layer is prepared from the following raw materials in percentage by mass: 70% of ethylene-propylene copolymer and 30% of styrene-ethylene-butadiene hydrogenated block copolymer; wherein the ethylene-propylene copolymer has a melt flow rate of 2.0g/10min at 230 ℃/2.16Kg measured according to GB-T3682; the styrene-ethylene-butadiene hydrogenated block copolymer had a melt flow rate of 3.0g/10min at 230 ℃/2.16Kg measured according to GB-T3682; the thickness is 20 to 40 μm. The specific implementation is shown in table 1.
TABLE 1
Outer layer (mum) | Second outer layer (mum) | Middle layer (mum) | Inner sublayer (mum) | Inner layer (mum) | |
Example 1 | 20 | 10 | 100 | 10 | 20 |
Example 2 | 20 | 10 | 120 | 10 | 20 |
Example 3 | 20 | 10 | 140 | 10 | 20 |
Example 4 | 30 | 20 | 120 | 20 | 30 |
The performance of the film part is tested according to the national standard YBB00112005-2015, and the related performance is as follows:
the above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and it will be apparent to those skilled in the art that any modifications, equivalent substitutions, improvements and the like that are within the spirit and principle of the present invention are included within the scope of the present invention.
Claims (7)
1. A preparation process of a five-layer co-extrusion film for transfusion is characterized by comprising the following steps:
step SO1, respectively sucking five layers of raw materials into 5 extruder hoppers, feeding the five layers of raw materials by a hopper feeding screw according to preset mass percentage, conveying plastic particles to a mixing hopper, mixing the materials, then feeding the mixture into each heating section of an extruder, melting and plasticizing the plastic particles by controlling the heating temperature of each section of the extruder to respectively obtain a molten mixture, wherein the temperature of the 5 extruders is that of an outer layer extruder: 170-240 ℃, secondary outer layer extruder: 100-240 ℃, middle layer extruder: 100-230 ℃, secondary inner layer extruder: 100-230 ℃, inner layer extruder: 170-240 ℃;
step SO2, filtering impurities from the fully plasticized mixture through a filter screen, redistributing and extruding through a connecting pipeline and a die head, and laminating five layers together at a die head to form a five-layer co-extruded film blank; five layers of co-extruded films are formed,
the outer layer is composed of homopolymerized polypropylene and styrene-ethylene-butadiene hydrogenation block copolymer;
the secondary outer layer is composed of ethylene methyl acrylate copolymer and modified linear low-density polyethylene;
the middle layer is composed of ethylene-octene copolymer and modified linear low-density polyethylene;
the secondary inner layer is composed of metallocene low-density polyethylene and linear low-density polyethylene;
the inner layer is composed of ethylene-propylene copolymer and styrene-ethylene-butadiene hydrogenation block copolymer;
the outer layer is composed of the following raw materials in percentage by mass: 80-95% of homo-polypropylene, 5-20% of styrene-ethylene-butadiene hydrogenated block copolymer and 20-30 μm thick;
the secondary outer layer is composed of the following raw materials in percentage by mass: 70-95% of ethylene methyl acrylate copolymer, 5-30% of modified linear low-density polyethylene and 10-20 mu m in thickness;
the middle layer is composed of the following raw materials in percentage by mass: 60-80% of ethylene-octene copolymer, 20-40% of modified linear low-density polyethylene and 120-140 μm in thickness;
the secondary inner layer is composed of the following raw materials in percentage by mass: 50-90% of metallocene low-density polyethylene, 10-50% of linear low-density polyethylene and 10-20 μm in thickness;
the inner layer is composed of the following raw materials in percentage by mass: 70-90% of ethylene-propylene copolymer, 10-30% of styrene-ethylene-butadiene hydrogenated block copolymer and 20-40 μm in thickness;
the die head temperature is 160-250 ℃, a planar superposition die head is adopted, after extrusion through the die head, a lower blown film bubble is formed by clean air, the blow-up ratio is 1.5-3, the blowing pressure is 0.4-0.8 MPa, the cooling water temperature is 10-35 ℃, and the flow rate is 1500-4000L/h;
the film bubble is cooled by clean air and purified water, and is folded and leveled by a herringbone clamping plate, and then enters a winding machine for winding.
2. The preparation process of the five-layer co-extrusion transfusion film as claimed in claim 1, wherein the homo-polypropylene used in the outer layer has a melting point of 155-175 ℃ and a density of 0.87-0.92 g/cm3The melt index is 4.0-9.0 g/10 min; a hydrogenated styrene-ethylene-butadiene block copolymer having a density of 0.87 to 0.92g/cm3The melt index is 2.0-5.0 g/10 min.
3. The preparation process of the five-layer co-extrusion transfusion film as claimed in claim 1, wherein the ethylene methyl acrylate copolymer used in the secondary outer layer has a melting point of 80-100 ℃ and a density of 0.9-1.1 g/cm3The melt index is 2-10 g/10 min; the modified linear low-density polyethylene has a melting point of 100-130 ℃ and a density of 0.9-0.92 g/cm3The melt index is 0.5 to 3g/10 min.
4. The preparation process of the five-layer co-extrusion transfusion film as claimed in claim 1, wherein the ethylene-octene copolymer used in the intermediate layer has a melting point of 90-120 ℃ and a density of 0.89-0.92 g/cm3The melt index is 0.5-1.5 g/10 min; the modified linear low-density polyethylene has a melting point of 100-130 ℃ and a density of 0.9-0.92 g/cm3The melt index is 0.5 to 3g/10 min.
5. The preparation process of the five-layer co-extrusion transfusion film as claimed in claim 1, wherein the metallocene low density polyethylene used in the secondary inner layer has a melting point of 60-120 ℃ and a density of 0.85-0.94 g/cm3The melt index is 0.5-3.0 g/10 min; linear low density polyethylene with melting point of 100-130 deg.C and density of 0.9-0.92 g/cm3The melt index is 0.5 to 3g/10 min.
6. The preparation process of the five-layer co-extrusion transfusion film as claimed in claim 1, wherein the ethylene-propylene copolymer used in the inner layer has a melting point of 120-145 ℃ and a density of 0.85-0.93 g/cm3The melt index is 0.5-3.0 g/10 min; a hydrogenated styrene-ethylene-butadiene block copolymer having a density of 0.87 to 0.92g/cm3The melt index is 2.0-5.0 g/10 min.
7. The preparation process of the five-layer co-extrusion transfusion film as claimed in claim 1, wherein the step of separately controlling the rotation speed of the extruder in SO2 specifically comprises the following steps: an outer layer extruder: 25-40 rpm, secondary outer layer extruder: 30-50 rpm, middle layer extruder: 45-75 rpm, secondary inner layer extruder: 40-70 r/min, inner layer extruder: 30-60 rpm.
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CN102837475A (en) * | 2012-08-31 | 2012-12-26 | 瑞安市高分子材料研究院有限公司 | Pharmaceutical package based five-layer co-extruded composite film |
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