CN108355412A - A kind of clean by laminar flow device and the eyedrops production line using the clean by laminar flow device - Google Patents
A kind of clean by laminar flow device and the eyedrops production line using the clean by laminar flow device Download PDFInfo
- Publication number
- CN108355412A CN108355412A CN201810214535.7A CN201810214535A CN108355412A CN 108355412 A CN108355412 A CN 108355412A CN 201810214535 A CN201810214535 A CN 201810214535A CN 108355412 A CN108355412 A CN 108355412A
- Authority
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- China
- Prior art keywords
- clean
- filter assemblies
- laminar flow
- flow device
- edge
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003889 eye drop Substances 0.000 title claims description 11
- 229940012356 eye drops Drugs 0.000 title claims description 11
- 238000004519 manufacturing process Methods 0.000 title claims description 5
- 230000000712 assembly Effects 0.000 claims abstract description 59
- 238000000429 assembly Methods 0.000 claims abstract description 59
- 239000007788 liquid Substances 0.000 claims abstract description 44
- 238000007789 sealing Methods 0.000 claims abstract description 34
- 238000009434 installation Methods 0.000 claims abstract description 26
- 239000012530 fluid Substances 0.000 claims abstract description 21
- 238000002347 injection Methods 0.000 claims description 19
- 239000007924 injection Substances 0.000 claims description 19
- 238000009826 distribution Methods 0.000 claims description 18
- 238000003860 storage Methods 0.000 claims description 4
- 238000007689 inspection Methods 0.000 claims 1
- 230000003749 cleanliness Effects 0.000 abstract description 10
- 238000010586 diagram Methods 0.000 description 5
- 238000001914 filtration Methods 0.000 description 5
- 238000000746 purification Methods 0.000 description 5
- 238000007664 blowing Methods 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 238000012423 maintenance Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000008859 change Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 208000030533 eye disease Diseases 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D46/00—Filters or filtering processes specially modified for separating dispersed particles from gases or vapours
- B01D46/0002—Casings; Housings; Frame constructions
- B01D46/0005—Mounting of filtering elements within casings, housings or frames
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D46/00—Filters or filtering processes specially modified for separating dispersed particles from gases or vapours
- B01D46/56—Filters or filtering processes specially modified for separating dispersed particles from gases or vapours with multiple filtering elements, characterised by their mutual disposition
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/80—Mixing plants; Combinations of mixers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/181—Preventing generation of dust or dirt; Sieves; Filters
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/22—Mixing of ingredients for pharmaceutical or medical compositions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/2202—Mixing compositions or mixers in the medical or veterinary field
Abstract
The invention discloses a kind of clean by laminar flow devices, including filter assemblies and frame, the frame includes the installation unit that several are provided with mounting groove, the installation unit upper surface circumferentially fixed is equipped with appearance liquid bath along its, the filter assemblies are embedded in mounting groove and filter assemblies periphery is equipped with edge, the edge, which is embedded at, to be held in liquid bath, and sealing fluid is filled in the appearance liquid bath.Edge surrounding is surrounded by sealing fluid, to make around edge and gapless can allow air to be flowed.To make have good leakproofness between filter assemblies and framework, and then make that frame can not be spilt into back to filter assemblies side without filtered air, the space equipped with the purifier is made to have preferable cleanliness factor.
Description
Technical field
The present invention relates to pharmaceutical equipment technical fields, and in particular to a kind of clean by laminar flow device and is filled using the clean by laminar flow
The eyedrops production line set.
Background technology
Eyedrops is a kind of one of most common pharmaceutical dosage form of ophthalmology disease, and for present a variety of eye disease, eyedrops is all
There is direct, efficiently therapeutic effect.Since eyedrops is drug and directly pleasing to the eye, therefore purity requirements are higher when filling.
It is general filling all to be carried out in laminar flow cleaning room.
Such as application No. is the patent of CN200820161619.0, which disclose a kind of laminar flow clean room, including one clean
Clear space, combined type purification air-conditioner and the frame being arranged at the top of clean room, the outlet air of the combined type purification air-conditioner
Mouth is connected to the top of the negative pressure space above frame, the air inlet and the return air on the outside of clean room of combined type purification air-conditioner
Channel is connected to, and is coordinated on the frame and is covered with blower fan filtering component.
At work, when the air outlet of combined type purification air-conditioner is sent into air to negative pressure space, the wind on frame
Machine filter assemblies (FFU) are started to work, and since each FFU units are there are one pressure fan, the lower section of pressure fan has filter,
Thus FFU will be constantly sent into after the air filtration in negative pressure space in clean room, form constant clean gas flow, air-flow from
Trepanning on clean room floor enters return air channel, and at the top of return air channel, a part of air-flow passes through negative pressure space side wall
Through-hole enters a part of the negative pressure space as air inlet, and another part is recycled to the air inlet of combined type purification air-conditioner with again
It utilizes, forms airflow circulating.To make room air keep clean.
In actual use, there can be gap between filter assemblies and frame, lead to the air of filtered component filters
It enters in clean room, and then influences the cleanliness factor in clean room.
Invention content
In view of the deficiencies of the prior art, the present invention intends to provide a kind of clean by laminar flow device, make filtering group
There is preferable leakproofness between part and frame, improve the cleanliness factor for being mounted with the purifier space.
To achieve the above object, the present invention provides following technical solutions:
A kind of clean by laminar flow device, including filter assemblies and frame, the frame include the installation list that several are provided with mounting groove
Member, the installation unit upper surface along its it is circumferentially fixed appearance liquid bath is installed, the filter assemblies are embedded in mounting groove and mistake
It filters component periphery and is equipped with edge, the edge, which is embedded at, to be held in liquid bath, and sealing fluid is filled in the appearance liquid bath.
By using above-mentioned technical proposal, edge surrounding is surrounded by sealing fluid, and to make around edge, simultaneously gapless can
Air is allowed to be flowed.To make have good leakproofness between filter assemblies and framework, and then make without filtered air
Frame can not be spilt into back to filter assemblies side, the space equipped with the purifier is made to have preferable cleanliness factor.
The further setting of the present invention is:The sealing fluid is in gel.
By using above-mentioned technical proposal, adsorbable certain dust, while reducing between framework and filter assemblies
Gap, reduce without filtered air can not spill into frame back to filter assemblies side probability.Sealing fluid is in simultaneously
Gel can make edge is more stable to be mounted in sealing fluid.
The further setting of the present invention is:The appearance liquid bath bottom surface is vertically equipped with liquid injection pipe, and the liquid injection pipe connects
Logical installation unit lower face, and the liquid injection pipe is inclined to set, the liquid injection pipe is vertically highly more than and holds liquid in deep
Degree, the interior sealing-plug being equipped with for sealing liquid injection pipe of the liquid injection pipe.
By using above-mentioned technical proposal, pipeline can be penetrated by column liquid pipe and be held in liquid bath, carry out pumping old sealing
Liquid imports new sealing fluid, to which the installation and replacement of sealing fluid, section can be completed under the premise of not dismantling filter assemblies
About maintenance time.
The further setting of the present invention is:The edge section is L-shaped.
By using above-mentioned technical proposal, and then edge is made to be immersed in sealing fluid as far as possible, improves leakproofness.
The further setting of the present invention is:The filter assemblies section is in polygon, and the edge is equipped with a plurality of and one
Edge corresponds to a filter assemblies side.
By using above-mentioned technical proposal, to make filter assemblies by multi-point support, make what it can be more stable to be mounted on
On frame.Also ensure that the edge on each side of filter assemblies is respectively positioned in sealing fluid simultaneously.Make the sky without filtering in turn
Gas can not spill into frame back to filter assemblies side, further ensure the cleanliness factor in the space equipped with the purifier.
The further setting of the present invention is:The mounting groove inner wall is circumferentially with sealing strip along it, and the sealing strip abuts
In filter assemblies.
By using above-mentioned technical proposal, sealing strip can further decrease between mounting groove inner wall and filter assemblies away from
From, and then make that frame can not be spilt into back to filter assemblies side without filtered air, it further ensures net equipped with this
Disguise the cleanliness factor in the space set.
The further setting of the present invention is:It is arranged with flow distribution plate in the mounting groove, is evenly equipped on the flow distribution plate several
Tap hole, the flow distribution plate are located at below filter assemblies and are connected to filter assemblies.
Dispersion is preferably shunted by using above-mentioned technical proposal, and then by the filtered air of filter assemblies, and then is made
Clean air is uniformly covered with entire space as far as possible.
The further setting of the present invention is:The tap hole is hexagonal.
By using above-mentioned technical proposal, to make flow distribution plate have better structural strength, reduce its deformation can
It can property.
The further setting of the present invention is:The installation unit lower face is rotatably connected to support plate in the horizontal direction, institute
It states support plate and is connected to flow distribution plate.
It is rotatable to prop up after being all installed to filter assemblies and flow distribution plate in mounting groove by using above-mentioned technical proposal
Fagging makes support plate be connected to flow distribution plate.And then making filter assemblies that can preferably be supported, installation is more stable.
Another object of the present invention is to provide a kind of eyedrops producing lines, and filling room is made to have higher cleanliness factor, improve
The safety of yields and eyedrops.
To achieve the above object, the present invention provides following technical solutions:
The further setting of the present invention is:A kind of eyedrops producing line, successively include storage compartment, proportioning room, liquor room, control laboratory,
Filling room and packer's bay, the filling indoor location is just like the clean by laminar flow device described in any one of claim 1-9.
The present invention has the following advantages:1, make that there is preferable leakproofness between filter assemblies and frame, improve installation
The cleanliness factor in the purifier space;2, maintenance efficiency is higher, and filter assemblies are easy for installation.
Description of the drawings
Fig. 1 is the structural schematic diagram of embodiment one;
Fig. 2 is the structural schematic diagram of installation unit in embodiment one;
Fig. 3 is the vertical view of installation unit in embodiment one;
Fig. 4 is that installation unit is holding the sectional view at liquid bath in embodiment one;
Fig. 5 is the structural schematic diagram of flow distribution plate in embodiment one;
Fig. 6 is the structural schematic diagram of embodiment two;
Fig. 7 is the structural schematic diagram of filling room in embodiment two.
Reference numeral:1, filter assemblies;2, frame;3, mounting groove;4, installation unit;5, blowing unit;6, filter element;
7, hold liquid bath;8, edge;9, transverse slat;10, riser;11, sealing strip;12, sealing fluid;13, liquid injection pipe;14, sealing-plug;15, divide
Flowing plate;16, tap hole;17, support plate;18, storage compartment;19, proportioning room;20, liquor room;21, control laboratory;22, filling room;
23, packer's bay;24, clean by laminar flow device;25, cavity;26, air inlet;27, exhaust outlet.
Specific implementation mode
With reference to attached drawing, the present invention will be further described.
Embodiment one:
As shown in Figure 1, a kind of clean by laminar flow device, including filter assemblies 1 and frame 2.As depicted in figs. 1 and 2, frame 2 includes
Several are provided with the installation unit 4 of mounting groove 3.As shown in Fig. 2, 1 section of filter assemblies is in polygon, and filter assemblies 1 are embedded
In in mounting groove 3.Filter assemblies 1 include blowing unit 5 and the filter element 6 positioned at 5 lower section of blowing unit.
As shown in Fig. 2, in order to make what filter assemblies 1 can be more stable to be mounted in mounting groove 3,4 upper surface edge of installation unit
Its circumferentially fixed is equipped with holds liquid bath 7.As shown in Figures 2 and 3,1 periphery of filter assemblies is fixedly installed edge 8, and edge 8 is equipped with
An a plurality of and edge 8 corresponds to 1 side of filter assemblies.Also it is in be fixedly connected between adjacent edge 8.Edge 8 includes along water
Square to setting transverse slat 9 and riser 10 vertically, riser is fixedly connected on transverse slat 9.That is 8 section of edge is L-shaped.Card
Side 8 is fixedly connected on filter assemblies 1, and is constantly in downward opening state.
As shown in Fig. 2, in order to improve the leakproofness between filter assemblies 1 and frame 2,3 inner wall of mounting groove is set along its circumferential direction
There are sealing strip 11, sealing strip 11 to be connected to filter assemblies 1.Hold simultaneously and be filled with sealing fluid 12 in liquid bath 7, sealing fluid 12 is in gel
Shape.Edge 8 is immersed in sealing fluid 12.Hold liquid bath 7 to more easily inject sealing fluid 12, holds 7 bottom surface of liquid bath along perpendicular
Histogram is to equipped with liquid injection pipe 13.As shown in Figure 2 and Figure 4, liquid injection pipe 13 is connected to 4 lower face of installation unit, and liquid injection pipe 13 is in incline
Tiltedly setting.Vertically height is more than appearance liquid in depth to liquid injection pipe 13.It is equipped in liquid injection pipe 13 for sealing liquid injection pipe 13
Sealing-plug 14.Sealing-plug 14 is fabricated from a flexible material, such as rubber.
As shown in Fig. 2, being also arranged with flow distribution plate 15 in mounting groove 3.As shown in figure 5, being evenly equipped with several points on flow distribution plate 15
Discharge orifice 16, tap hole 16 are hexagonal.As shown in Fig. 2, flow distribution plate 15 is located at 1 lower section of filter assemblies and is connected to filter assemblies 1.
More stable in order to make filter assemblies 1 install, 4 lower face of installation unit is rotatably connected to support plate 17 in the horizontal direction, support
Plate 17 is connected to flow distribution plate 15.
The principle of the clean by laminar flow device is as follows:
When mounted, when mounted, it needs that first the installation card of filter assemblies 1 from top to down is set in mounting groove 3, then by frame 2
It is installed to interior.Then flow distribution plate 15 is caught in mounting groove 3, is rotated further by support plate 17, it is made to be connected to flow distribution plate 15.
It so repeats, until all filter assemblies 1 are mounted in frame 2.
Finally by liquid injection pipe 13 sealing fluid 12 is injected into appearance liquid bath 7.Also interior can be installed in frame 2
Before, sealing fluid 12 is just injected in holding tank 7, then frame 2 is installed to interior.
It when being worked due to edge 8, is immersed in sealing fluid 12, therefore there is the sealing added between filter assemblies 1 and frame 2
Property.The air of 2 top of frame can then flow into 2 lower section of frame after the filtering of filter assemblies 1, and then ensure and use the laminar flow
The cleanliness factor in the space of purifier.
If needing to change filter assemblies 1, support plate 17 only need to be turned on, takes out flow distribution plate 15, finally by filter assemblies 1 from installation
It extracts in slot 3, the step of when repeating installation, new filter assemblies 1 is installed in mounting groove 3.It replaces convenient and efficient.
Embodiment two:
A kind of eyedrops production line includes storage compartment 18, proportioning room 19, liquor room 20, control laboratory 21, filling room 22 and packet successively
Room 23 is filled, 22 top of filling room is equipped with the clean by laminar flow device 24 as described in embodiment one.Clean by laminar flow device 24 and filling
When top surface formed cavity 25,25 inner wall of cavity be equipped with air inlet 26.22 lower end of filling room, four side side wall is equipped with exhaust outlet 27.
At work, air is entered from air inlet 26 in cavity 25, is endlessly into crossing after filter assemblies 1 filter
Filling room 22 provides fresh air.Exhaust gas is then discharged from exhaust outlet 27.And then to ensure the cleanliness factor of filling room 22.
The above is only a preferred embodiment of the present invention, protection scope of the present invention is not limited merely to above-mentioned implementation
Example, all technical solutions belonged under thinking of the present invention all belong to the scope of protection of the present invention.It should be pointed out that for the art
Those of ordinary skill for, several improvements and modifications without departing from the principles of the present invention, these improvements and modifications
It should be regarded as protection scope of the present invention.
Claims (10)
1. a kind of clean by laminar flow device, including filter assemblies(1)And frame(2), it is characterized in that:The frame(2)Including several
It is a to be provided with mounting groove(3)Installation unit(4), the installation unit(4)Upper surface circumferentially fixed is equipped with appearance liquid bath along its
(7), the filter assemblies(1)It is embedded at mounting groove(3)Interior and filter assemblies(1)Periphery is equipped with edge(8), the edge(8)
It is embedded at appearance liquid bath(7)It is interior, the appearance liquid bath(7)It is interior to be filled with sealing fluid(12).
2. a kind of clean by laminar flow device according to claim 1, it is characterized in that:The sealing fluid(12)In gel.
3. a kind of clean by laminar flow device according to claim 1, it is characterized in that:The appearance liquid bath(7)Bottom surface is along vertical side
To equipped with liquid injection pipe(13), the liquid injection pipe(13)It is connected to installation unit(4)Lower face, and the liquid injection pipe(13)It is inclined to set
It sets, the liquid injection pipe(13)It is in depth, the liquid injection pipe that vertically height, which is more than and holds liquid,(13)It is interior to be equipped with for sealing note
Liquid pipe(13)Sealing-plug(14).
4. a kind of clean by laminar flow device according to claim 1, it is characterized in that:The edge(8)Section is L-shaped.
5. a kind of clean by laminar flow device according to claim 4, it is characterized in that:The filter assemblies(1)Section is in polygon
Shape, the edge(8)Equipped with an a plurality of and edge(8)A corresponding filter assemblies(1)Side.
6. a kind of clean by laminar flow device according to claim 4, it is characterized in that:The mounting groove(3)Inner wall is along its circumferential direction
Equipped with sealing strip(11), the sealing strip(11)It is connected to filter assemblies(1).
7. a kind of clean by laminar flow device according to claim 4, it is characterized in that:The mounting groove(3)Inside it is arranged with shunting
Plate(15), the flow distribution plate(15)On be evenly equipped with several tap holes(16), the flow distribution plate(15)Positioned at filter assemblies(1)Lower section
And it is connected to filter assemblies(1).
8. a kind of clean by laminar flow device according to claim 7, it is characterized in that:The tap hole(16)It is hexagonal.
9. a kind of clean by laminar flow device according to claim 7, it is characterized in that:The installation unit(4)Lower face Yan Shui
Square to being rotatably connected to support plate(17), the support plate(17)It is connected to flow distribution plate(15).
10. a kind of eyedrops production line, it is characterized in that:Include storage compartment successively(18), proportioning room(19), liquor room(20), inspection
Test room(21), filling room(22)The packer's bay and(23), the filling room(22)Interior installation is just like any one of claim 1-9
The clean by laminar flow device(24).
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810214535.7A CN108355412A (en) | 2018-03-15 | 2018-03-15 | A kind of clean by laminar flow device and the eyedrops production line using the clean by laminar flow device |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810214535.7A CN108355412A (en) | 2018-03-15 | 2018-03-15 | A kind of clean by laminar flow device and the eyedrops production line using the clean by laminar flow device |
Publications (1)
Publication Number | Publication Date |
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CN108355412A true CN108355412A (en) | 2018-08-03 |
Family
ID=63000289
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN201810214535.7A Pending CN108355412A (en) | 2018-03-15 | 2018-03-15 | A kind of clean by laminar flow device and the eyedrops production line using the clean by laminar flow device |
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CN (1) | CN108355412A (en) |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5926118A (en) * | 1982-08-02 | 1984-02-10 | Fujita Corp | Apparatus for attaching filter |
FR2561537A1 (en) * | 1984-03-20 | 1985-09-27 | Poelman Sofiltra | Filtering structure with laminar air flow with incorporated lighting |
DE10204505A1 (en) * | 2002-02-05 | 2003-09-04 | Mann & Hummel Filter | Forming a seal at a filter, an upper mold section is placed over a molding groove at the filter, giving a hollow zone to be filled with an injected sealant |
CN1517089A (en) * | 2003-01-15 | 2004-08-04 | 珊 赵 | Indometacin eyedrops |
CN204093191U (en) * | 2014-08-26 | 2015-01-14 | 张建清 | The double-deck laminar flow hood of a kind of steady type |
CN104671175A (en) * | 2015-02-15 | 2015-06-03 | 桂林华诺威基因药业有限公司 | Laminar flow protecting system of eye drop filling machine |
-
2018
- 2018-03-15 CN CN201810214535.7A patent/CN108355412A/en active Pending
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5926118A (en) * | 1982-08-02 | 1984-02-10 | Fujita Corp | Apparatus for attaching filter |
FR2561537A1 (en) * | 1984-03-20 | 1985-09-27 | Poelman Sofiltra | Filtering structure with laminar air flow with incorporated lighting |
DE10204505A1 (en) * | 2002-02-05 | 2003-09-04 | Mann & Hummel Filter | Forming a seal at a filter, an upper mold section is placed over a molding groove at the filter, giving a hollow zone to be filled with an injected sealant |
CN1517089A (en) * | 2003-01-15 | 2004-08-04 | 珊 赵 | Indometacin eyedrops |
CN204093191U (en) * | 2014-08-26 | 2015-01-14 | 张建清 | The double-deck laminar flow hood of a kind of steady type |
CN104671175A (en) * | 2015-02-15 | 2015-06-03 | 桂林华诺威基因药业有限公司 | Laminar flow protecting system of eye drop filling machine |
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Application publication date: 20180803 |
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