CN108341821B - Synthesis method of epinastine hydrochloride - Google Patents
Synthesis method of epinastine hydrochloride Download PDFInfo
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- CN108341821B CN108341821B CN201810315907.5A CN201810315907A CN108341821B CN 108341821 B CN108341821 B CN 108341821B CN 201810315907 A CN201810315907 A CN 201810315907A CN 108341821 B CN108341821 B CN 108341821B
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Abstract
The invention discloses a compound of epinastine hydrochlorideThe preparation method relates to the technical field of medicines, and comprises the following steps: with 6-cyano-6, 11-1H-dibenzo [ b, e ]]Aza derivatives
Taking methanol solution of ammonia as solvent in the presence of Raney-Ni, introducing hydrogen to carry out reduction reaction to obtain 6- (aminomethyl) -6, 11-dihydro-1H-dibenzo [ b, e-]Aza derivatives
Reacting 6- (aminomethyl) -6, 11-dihydro-1H-dibenzo [ b, e ]]Aza derivatives
Cyclizing with cyanogen bromide, and neutralizing with alkali to obtain 3-amino-9, 13 b-dihydro-1H-dibenzo [ c, f ]]Imidazo [1,5-a ]]Aza derivatives
Reacting 3-amino-9, 13 b-dihydro-1H-dibenzo [ c, f ]]Imidazo [1,5-a ]]Aza derivatives
Description
Technical Field
The invention relates to the technical field of medicines, in particular to a synthesis method of epinastine hydrochloride.
Background
Epinastine hydrochloride is known as epinastine hydrochloride and has the chemical name of 3-amino-9, 13-dihydro-1H-dibenzo [ c, f]Imidazo [1,5-a ]]Aza derivatives
The hydrochloride has the structure shown in the following formula, is an orally effective antihistamine developed by German Boringer Vargohne company, is further developed together with a Japanese tri-drug combination to develop a market, is first marketed in Japan in 1994, and has the trade name of 'Alesion'.
Epinastine hydrochloride is used for treating bronchial asthma, allergic dermatitis, urticaria, eczema, dermatitis and psoriasis vulgaris (psoriasis), has strong inhibitory effect on bronchoconstriction caused by histamine and bradykinin, has no inhibitory effect on bronchoconstriction caused by other chemical mediators, and is one of histamine H1 receptor antagonists with no sedative effect, which acts on peripheral nerves most effectively.
At present, the preparation method of epinastine hydrochloride mainly comprises the following steps:
with 6, 11-dihydro-5H-dibenzo [ b, e ]]Aza derivatives
Preparing 6-cyano-6, 11-1H-dibenzo [ b, e ] in the presence of DMSO as a starting material]Aza derivatives
Then reducing by lithium aluminum hydride or aluminum hydride to obtain 6- (aminomethyl) -6, 11-dihydro-1H-dibenzo [ b, e]Aza derivatives
And after the fumarate is converted into fumarate, the fumarate is cyclized with cyanogen bromide in ethanol to prepare the 3-amino-9, 13 b-dihydro-1H-dibenzo [ c, f]Imidazo [1,5-a ]]Aza derivatives
Suspending the mixture in methanol, and treating the mixture with HCl-ether solution to obtain epinastine hydrochloride. However, the method has many preparation steps, takes too long time, uses virulent sodium cyanide and expensive and flammable lithium aluminum hydride or aluminum hydride, has low yield in the reduction step, and is not suitable for large-scale industrial production; also 6-cyano-6, 11-1H-dibenzo [ b, e ]]Aza as the starting material, reduced by sodium borohydride, converted into fumarate, and refined to obtain 6- (aminomethyl) -6, 11-dihydro-1H dibenzo [ b, e]Aza derivatives
Then 3-amino-9, 13 b-dihydro-1H-dibenzo [ c, f ] is obtained by cyanogen bromide cyclization]Imidazo [1,5-a ]]Aza derivatives
And the hydrobromide is converted into epinastine by using sodium hydroxide and salified by using a hydrochloric acid ethanol solution, wherein boron is generated by using sodium borohydride as a reducing agent in the process, an impurity phase is introduced, and the yield in the reduction step is not high. Therefore, the application improves the synthesis process.
Disclosure of Invention
Based on the technical problems in the background art, the invention provides a synthesis method of epinastine hydrochloride, which has the advantages of high purity and yield of the epinastine hydrochloride, simple process and short time consumption.
The invention provides a synthesis method of epinastine hydrochloride, which comprises the following steps:
s1, 6-cyano-6, 11-1H-dibenzo [ b, e ]]Aza derivatives
Taking methanol solution of ammonia as solvent in the presence of Raney-Ni, introducing hydrogen to carry out reduction reaction to obtain 6- (aminomethyl) -6, 11-dihydro-1H-dibenzo [ b, e-]Aza derivatives
S2, mixing 6- (aminomethyl) -6, 11-dihydro-1H-dibenzo [ b, e]Aza derivatives
Cyclization with cyanogen bromide to give 3-amino-9, 13 b-dihydro-1H-dibenzo [ c, f]Imidazo [1,5-a ]]Aza derivatives
Neutralizing with alkali to obtain 3-amino-9, 13 b-dihydro-1H-dibenzo [ c, f ]]Imidazo [1,5-a ]]Aza derivatives
S3, reacting 3-amino-9, 13 b-dihydro-1H-dibenzo [ c, f]Imidazo [1,5-a ]]Aza derivatives
Salifying with hydrochloric acid to obtain the final product.
Preferably, in S1, 6-cyano-6, 11-1H-dibenzo [ b, e ] is substituted]Aza derivatives
Adding into a high-pressure reaction kettle, adding Raney-Ni and ammonia methanol solution, introducing hydrogen, stirring for reaction, filtering, concentrating the filtrate, recovering methanol, extracting, washing, and drying to obtain 6- (aminomethyl) -6, 11-1H-dibenzo [ b, e ]]Aza derivatives
Preferably, in the S1, 100 parts of 6-cyano-6, 11-1H-dibenzo [ b, e ] are added]Aza derivatives
Adding into a high-pressure reaction kettle, adding 4-8 parts of Raney-Ni and 500 parts of methanol solution of 400-ammonia, introducing hydrogen, stirring and reacting at 25-30 ℃ for 4-7H, filtering, concentrating the filtrate to recover methanol, adding dichloromethane for extraction, washing the extract with saturated saline solution, and drying to obtain 6- (aminomethyl) -6, 11-1H-dibenzo [ b, e ]]Aza derivatives
Preferably, in the S1, hydrogen is introduced, and the pressure in the high-pressure reaction kettle is controlled to be 2.5-3.0 MPa.
Preferably, in S1, the methanol solution of ammonia is prepared as follows: and (3) introducing ammonia gas into methanol in an ice bath until the ammonia gas is saturated, thus obtaining the methanol-methanol fuel.
Preferably, in the S2, 6- (aminomethyl) -6, 11-dihydro-1H-dibenzo [ b, e)]Aza derivatives
Dissolving with dichloromethane, adding cyanogen bromide, stirring for reaction, cooling after the reaction is finished, crystallizing, filtering, dissolving in water to prepare suspension, adjusting pH value to 10-11 with NaOH solution, stirring, cooling, crystallizing, filtering, washing filter cake with water to be neutral, and drying to obtain 3-amino-9, 13 b-dihydro-1H-dibenzo [ c, f ] -l-methyl-l-phenyl-N-methyl-ethyl-l-phenyl-N-methyl-L-phenyl-N-]Imidazo [1,5-a ]]Aza derivatives
Preferably, in S2, 100 parts of 6- (aminomethyl) -6, 11-dihydro-1H-dibenzo [ b, e ] are added]Aza derivatives
Dissolving with 400 parts of dichloromethane of 300-portions, adding 30-40 parts of cyanogen bromide, stirring and reacting for 12-15H at 25-30 ℃, cooling to 0-5 ℃ after the reaction is finished, crystallizing, filtering, dissolving the cyanogen bromide in 300 parts of water of 200-portions to prepare a suspension, adjusting the pH value to 10-11 with 10 percent NaOH solution, stirring for 2-3H, cooling to 0-5 ℃, crystallizing, filtering, washing a filter cake with water to be neutral, and drying to obtain the 3-amino-9, 13 b-dihydro-1H-dibenzo [ c, f ] with water]Imidazo [1,5-a ]]Aza derivatives
Preferably, in S3, 3-amino-9, 13 b-dihydro-1H-dibenzo [ c, f)]Imidazo [1,5-a ]]Aza derivatives
Adding into ethanol, stirring for dissolving, adding dropwise concentrated hydrochloric acid to adjust pH to 2-3, stirring, cooling, crystallizing, filtering, recrystallizing, filtering, and drying.
Preferably, in S3, 100 parts of 3-amino-9, 13 b-dihydro-1H-dibenzo [ c, f ] are added]Imidazo [1,5-a ]]Aza derivatives
Adding into 400-500 parts of ethanol, stirring for dissolving, dropwise adding concentrated hydrochloric acid to adjust the pH value to 2-3, stirring at room temperature for 3-5h, cooling to 0-5 ℃, crystallizing, filtering, and using filter cakeRecrystallizing with 60% ethanol, filtering, and drying.
Has the advantages that: the invention uses 6, 11-dihydro-5H-dibenzo [ b, e]Aza derivatives
The raw material is the initial raw material, the use of virulent sodium cyanide is avoided, Raney-Ni is used as a catalyst in the reduction step, the catalytic hydrogenation reaction is carried out in a methanol solution of ammonia, the reaction condition is mild, the reaction time is short, the yield of the reduction product can reach more than 90 percent, the whole synthesis process is stable, the reaction steps are simple, the time consumption is short, and the purity and the yield of the prepared epinastine hydrochloride are high.
Detailed Description
The technical solution of the present invention will be described in detail below with reference to specific examples.
Example 1
The invention provides a synthesis method of epinastine hydrochloride, which comprises the following steps:
s1, 6-cyano-6, 11-1H-dibenzo [ b, e ]]Aza derivatives
Taking methanol solution of ammonia as solvent in the presence of Raney-Ni, introducing hydrogen to carry out reduction reaction to obtain 6- (aminomethyl) -6, 11-dihydro-1H-dibenzo [ b, e-]Aza derivatives
S2, mixing 6- (aminomethyl) -6, 11-dihydro-1H-dibenzo [ b, e]Aza derivatives
Cyclization with cyanogen bromide to give 3-amino-9, 13 b-dihydro-1H-dibenzo [ c, f]Imidazo [1,5-a ]]Aza derivatives
Neutralizing with alkali to obtain 3-amino-9, 13 b-dihydro-1H-dibenzo [ c, f ]]Imidazo [1,5-a ]]Aza derivatives
S3, reacting 3-amino-9, 13 b-dihydro-1H-dibenzo [ c, f]Imidazo [1,5-a ]]Aza derivatives
Salifying with hydrochloric acid to obtain the final product.
Example 2
The invention provides a synthesis method of epinastine hydrochloride, which comprises the following steps:
s1, mixing 100 parts of 6-cyano-6, 11-1H-dibenzo [ b, e ]]Aza derivatives
Adding into a high-pressure reaction kettle, adding 4 parts of Raney-Ni and 400 parts of methanol solution of ammonia, introducing hydrogen, controlling the pressure in the high-pressure reaction kettle to be 2.5MPa, stirring and reacting at 25 ℃ for 4H, filtering, concentrating the filtrate to recover methanol, adding dichloromethane for extraction, washing the extract with saturated saline solution, and drying to obtain 6- (aminomethyl) -6, 11-1H-dibenzo [ b, e ]]Aza derivatives
Purifying by a chromatographic column to obtain the yield of 90.1 percent; the methanol solution of ammonia is prepared as follows: introducing ammonia gas into methanol in ice bath until saturation to obtain the product;
s2, mixing 100 shares of 6- (aminomethyl) -6, 11-dihydro-1H-dibenzo [ b, e ]]Aza derivatives
Dissolving with 300 parts of dichloromethane, adding 30 parts of cyanogen bromide, stirring and reacting at 25 ℃ for 12H, cooling to 0 ℃ after the reaction is finished, crystallizing, filtering, dissolving the cyanogen bromide in 200 parts of water to prepare a suspension, adjusting the pH value to 10 with 10% NaOH solution, stirring for 2H, cooling to 0 ℃, crystallizing, filtering, washing a filter cake to be neutral with water, and drying to obtain 3-amino-9, 13 b-dihydro-1H-dibenzo [ c, f ] dibenzo]Imidazo [1,5-a ]]Aza derivatives
S3, mixing 100 parts of 3-amino-9, 13 b-dihydro-1H-dibenzo [ c, f ]]Imidazo [1,5-a ]]Aza derivatives
Adding into 400 parts of ethanol, stirring for dissolving, dropwise adding concentrated hydrochloric acid to adjust the pH value to 2, stirring for 3h at room temperature, cooling to 0 ℃, crystallizing, filtering, recrystallizing a filter cake with 60% ethanol, filtering, and drying to obtain the product.
Example 3
The invention provides a synthesis method of epinastine hydrochloride, which comprises the following steps:
s1, mixing 100 parts of 6-cyano-6, 11-1H-dibenzo [ b, e ]]Aza derivatives
Adding into a high-pressure reaction kettle, adding 5 parts of Raney-Ni and 420 parts of methanol solution of ammonia, introducing hydrogen, controlling the pressure in the high-pressure reaction kettle to be 2.6MPa, stirring and reacting at 27 ℃ for 5H, filtering, concentrating the filtrate to recover methanol, adding dichloromethane for extraction, washing the extract with saturated saline solution, and drying to obtain 6- (aminomethyl) -6, 11-1H-dibenzo [ b, e ]]Aza derivatives
Purifying by a chromatographic column to obtain the yield of 91.8 percent; the methanol solution of ammonia is prepared as follows: introducing ammonia gas into methanol in ice bath until saturation to obtain the product;
s2, mixing 100 shares of 6- (aminomethyl) -6, 11-dihydro-1H-dibenzo [ b, e ]]Aza derivatives
Dissolving with 320 parts of dichloromethane, adding 32 parts of cyanogen bromide, stirring and reacting at 25 ℃ for 13H, cooling to 2 ℃ after the reaction is finished, crystallizing, filtering, dissolving the cyanogen bromide in 230 parts of water to prepare a suspension, adjusting the pH value to 10 with 10% NaOH solution, stirring for 2H, cooling to 2 ℃, crystallizing, filtering, washing a filter cake to be neutral with water, and drying to obtain 3-amino-9, 13 b-dihydro-1H-dibenzo [ c, f ] l]Imidazo [1,5-a ]]Aza derivatives
S3, mixing 100 parts of 3-amino-9, 13 b-dihydro-1H-dibenzo [ c, f ]]Imidazo [1,5-a ]]Aza derivatives
Adding into 420 parts of ethanol, stirring for dissolving, dropwise adding concentrated hydrochloric acid to adjust the pH value to 2, stirring at room temperature for 3.5h, cooling to 2 ℃, crystallizing, filtering, recrystallizing the filter cake with 60% ethanol, filtering, and drying to obtain the final product.
Example 4
The invention provides a synthesis method of epinastine hydrochloride, which comprises the following steps:
s1, mixing 100 parts of 6-cyano-6, 11-1H-dibenzo [ b, e ]]Aza derivatives
Adding into a high-pressure reaction kettle, adding 6 parts of Raney-Ni and 450 parts of methanol solution of ammonia, introducing hydrogen, controlling the pressure in the high-pressure reaction kettle to be 2.8MPa, stirring and reacting at 28 ℃ for 6H, filtering, concentrating the filtrate to recover methanol, adding dichloromethane for extraction, washing the extract with saturated saline solution, and drying to obtain 6- (aminomethyl) -6, 11-1H-dibenzo [ b, e ]]Aza derivatives
Purifying by a chromatographic column to obtain the yield of 93.3 percent; the methanol solution of ammonia is prepared as follows: introducing ammonia gas into methanol in ice bath until saturation to obtain the product;
s2, mixing 100 shares of 6- (aminomethyl) -6, 11-dihydro-1H-dibenzo [ b, e ]]Aza derivatives
Dissolving with 350 parts of dichloromethane, adding 35 parts of cyanogen bromide, stirring and reacting at 28 ℃ for 14h, cooling to 3 ℃ after the reaction is finished, crystallizing, filtering, dissolving the cyanogen bromide in 250 parts of water to prepare a suspension, adjusting the pH value to 10.5 with 10% NaOH solution, stirring for 2.5h, cooling to 3 ℃, crystallizing, filtering, washing a filter cake to be neutral with water, drying,to obtain 3-amino-9, 13 b-dihydro-1H-dibenzo [ c, f]Imidazo [1,5-a ]]Aza derivatives
S3, mixing 100 parts of 3-amino-9, 13 b-dihydro-1H-dibenzo [ c, f ]]Imidazo [1,5-a ]]Aza derivatives
Adding into 450 parts of ethanol, stirring for dissolving, dropwise adding concentrated hydrochloric acid to adjust the pH value to 2.5, stirring at room temperature for 4h, cooling to 3 ℃, crystallizing, filtering, recrystallizing a filter cake with 60% ethanol, filtering, and drying to obtain the product.
Example 5
The invention provides a synthesis method of epinastine hydrochloride, which comprises the following steps:
s1, mixing 100 parts of 6-cyano-6, 11-1H-dibenzo [ b, e ]]Aza derivatives
Adding into a high-pressure reaction kettle, adding 7 parts of Raney-Ni and 480 parts of ammonia methanol solution, introducing hydrogen, controlling the pressure in the high-pressure reaction kettle to be 3.0MPa, stirring and reacting at 30 ℃ for 6H, filtering, concentrating the filtrate to recover methanol, adding dichloromethane for extraction, washing the extract with saturated saline solution, and drying to obtain 6- (aminomethyl) -6, 11-1H-dibenzo [ b, e ]]Aza derivatives
Purifying by a chromatographic column to obtain the yield of 93.5 percent; the methanol solution of ammonia is prepared as follows: introducing ammonia gas into methanol in ice bath until saturation to obtain the product;
s2, mixing 100 shares of 6- (aminomethyl) -6, 11-dihydro-1H-dibenzo [ b, e ]]Aza derivatives
Dissolving with 350 parts of dichloromethane, adding 38 parts of cyanogen bromide, stirring and reacting at 25 ℃ for 14 hours, cooling to 3 ℃ after the reaction is finished, crystallizing, filtering, dissolving in 250 parts of water to prepare suspension, and adjusting the pH value with 10% NaOH solutionStirring for 3H to 10.5, cooling to 2 deg.C, crystallizing, filtering, washing filter cake to neutral with water, and drying to obtain 3-amino-9, 13 b-dihydro-1H-dibenzo [ c, f ]]Imidazo [1,5-a ]]Aza derivatives
S3, mixing 100 parts of 3-amino-9, 13 b-dihydro-1H-dibenzo [ c, f ]]Imidazo [1,5-a ]]Aza derivatives
Adding into 450 parts of ethanol, stirring for dissolving, dropwise adding concentrated hydrochloric acid to adjust the pH value to 3, stirring for 4 hours at room temperature, cooling to 2 ℃, crystallizing, filtering, recrystallizing a filter cake with 60% ethanol, filtering, and drying to obtain the product.
Example 6
The invention provides a synthesis method of epinastine hydrochloride, which comprises the following steps:
s1, mixing 100 parts of 6-cyano-6, 11-1H-dibenzo [ b, e ]]Aza derivatives
Adding into a high-pressure reaction kettle, adding 8 parts of Raney-Ni and 500 parts of ammonia methanol solution, introducing hydrogen, controlling the pressure in the high-pressure reaction kettle to be 3.0MPa, stirring and reacting at 30 ℃ for 7H, filtering, concentrating the filtrate to recover methanol, adding dichloromethane for extraction, washing the extract with saturated saline solution, and drying to obtain 6- (aminomethyl) -6, 11-1H-dibenzo [ b, e ] dibenzo]Aza derivatives
Purifying by a chromatographic column to obtain the yield of 93.0 percent; the methanol solution of ammonia is prepared as follows: introducing ammonia gas into methanol in ice bath until saturation to obtain the product;
s2, mixing 100 shares of 6- (aminomethyl) -6, 11-dihydro-1H-dibenzo [ b, e ]]Aza derivatives
Dissolving with 400 parts of dichloromethane, adding 40 parts of cyanogen bromide, stirring and reacting at 30 ℃ for 15 hours, and cooling to the temperature ofCrystallizing at 5 deg.C, vacuum filtering, dissolving in 300 parts of water to obtain suspension, adjusting pH to 11 with 10% NaOH solution, stirring for 3 hr, cooling to 5 deg.C, crystallizing, filtering, washing filter cake with water to neutrality, and drying to obtain 3-amino-9, 13 b-dihydro-1H-dibenzo [ c, f ] dibenzo [ e]Imidazo [1,5-a ]]Aza derivatives
S3, mixing 100 parts of 3-amino-9, 13 b-dihydro-1H-dibenzo [ c, f ]]Imidazo [1,5-a ]]Aza derivatives
Adding into 500 parts of ethanol, stirring for dissolving, dropwise adding concentrated hydrochloric acid to adjust the pH value to 3, stirring at room temperature for 5h, cooling to 5 ℃, crystallizing, filtering, recrystallizing a filter cake with 60% ethanol, filtering, and drying to obtain the product.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (22)
1. A synthetic method of epinastine hydrochloride is characterized by comprising the following steps:
s1, 6-cyano-6, 11-1H-dibenzo [ b, e ]]Aza derivatives
Taking methanol solution of ammonia as solvent in the presence of Raney-Ni, introducing hydrogen to carry out reduction reaction to obtain 6- (aminomethyl) -6, 11-dihydro-1H-dibenzo [ b, e-]Aza derivatives
S2, mixing 6- (aminomethyl) -6, 11-dihydro-1H-dibenzo [ b, e]Aza derivatives
Cyclization with cyanogen bromide to give 3-amino-9, 13 b-dihydro-1H-dibenzo [ c, f]Imidazo [1,5-a ]]Aza derivatives
Neutralizing with alkali to obtain 3-amino-9, 13 b-dihydro-1H-dibenzo [ c, f ]]Imidazo [1,5-a ]]Aza derivatives
S3, reacting 3-amino-9, 13 b-dihydro-1H-dibenzo [ c, f]Imidazo [1,5-a ]]Aza derivatives
Salifying with hydrochloric acid to obtain the final product.
2. The method of synthesizing epinastine hydrochloride according to claim 1, wherein 6-cyano-6, 11-1H-dibenzo [ b, e ] is used in S1]Aza derivatives
Adding into a high-pressure reaction kettle, adding Raney-Ni and ammonia methanol solution, introducing hydrogen, stirring for reaction, filtering, concentrating the filtrate, recovering methanol, extracting, washing, and drying to obtain 6- (aminomethyl) -6, 11-1H-dibenzo [ b, e ]]Aza derivatives
3. The method for synthesizing epinastine hydrochloride according to claim 1 or 2, wherein 100 parts of 6-cyano-6, 11-1H-dibenzo [ b, e ] in S1]Aza derivatives
Adding into a high-pressure reaction kettle, adding 4-8 parts of Raney-Ni and 500 parts of ammonia methanol solution, introducing hydrogen, stirring and reacting at 25-30 ℃ for 4-7h, filtering, concentrating the filtrateCollecting methanol, extracting with dichloromethane, washing the extractive solution with saturated saline, and drying to obtain 6- (aminomethyl) -6, 11-1H-dibenzo [ b, e ]]Aza derivatives
4. The method for synthesizing epinastine hydrochloride according to claim 1 or 2, wherein hydrogen is introduced into the S1, and the pressure in the autoclave is controlled to be 2.5 to 3.0 MPa.
5. The method for synthesizing epinastine hydrochloride according to claim 3, wherein hydrogen is introduced into S1, and the pressure in the autoclave is controlled to be 2.5-3.0 MPa.
6. The method for synthesizing epinastine hydrochloride according to claim 1 or 2, wherein the methanol solution of ammonia in S1 is prepared as follows: and (3) introducing ammonia gas into methanol in an ice bath until the ammonia gas is saturated, thus obtaining the methanol-methanol fuel.
7. The method for synthesizing epinastine hydrochloride according to claim 3, wherein the methanol solution of ammonia in S1 is prepared as follows: and (3) introducing ammonia gas into methanol in an ice bath until the ammonia gas is saturated, thus obtaining the methanol-methanol fuel.
8. The method for synthesizing epinastine hydrochloride according to claim 4, wherein the methanol solution of ammonia in S1 is prepared as follows: and (3) introducing ammonia gas into methanol in an ice bath until the ammonia gas is saturated, thus obtaining the methanol-methanol fuel.
9. The method for synthesizing epinastine hydrochloride according to claim 1 or 2, wherein in S2, 6- (aminomethyl) -6, 11-dihydro-1H-dibenzo [ b, e ] is reacted with]Aza derivatives
With dichloromethaneDissolving, adding cyanogen bromide, stirring for reaction, cooling after the reaction is finished, crystallizing, filtering, dissolving the cyanogen bromide in water to prepare a suspension, adjusting the pH value to 10-11 by using NaOH solution, stirring, cooling, crystallizing, filtering, washing a filter cake to be neutral by using water, and drying to obtain the 3-amino-9, 13 b-dihydro-1H-dibenzo [ c, f ] 2]Imidazo [1,5-a ]]Aza derivatives
10. The method for synthesizing epinastine hydrochloride according to claim 1 or 2, wherein 100 parts of 6- (aminomethyl) -6, 11-dihydro-1H-dibenzo [ b, e ] is used in S2]Aza derivatives
Dissolving with 400 parts of dichloromethane of 300-portions, adding 30-40 parts of cyanogen bromide, stirring and reacting for 12-15H at 25-30 ℃, cooling to 0-5 ℃ after the reaction is finished, crystallizing, filtering, dissolving the cyanogen bromide in 300 parts of water of 200-portions to prepare a suspension, adjusting the pH value to 10-11 with 10 percent NaOH solution, stirring for 2-3H, cooling to 0-5 ℃, crystallizing, filtering, washing a filter cake with water to be neutral, and drying to obtain the 3-amino-9, 13 b-dihydro-1H-dibenzo [ c, f ] with water]Imidazo [1,5-a ]]Aza derivatives
11. The method for synthesizing epinastine hydrochloride according to claim 3, wherein 100 parts of 6- (aminomethyl) -6, 11-dihydro-1H-dibenzo [ b, e ] is used in S2]Aza derivatives
Dissolving with 400 parts of 300-portion of dichloromethane, adding 30-40 parts of cyanogen bromide, stirring and reacting at 25-30 ℃ for 12-15h, cooling to 0-5 ℃ after the reaction is finished, crystallizing, filtering, dissolving the cyanogen bromide in 300 parts of water of 200-portion of dichloromethane to prepare a suspension, adjusting the pH value to 10-11 with 10% NaOH solution, stirring for 2-3h, cooling to 0-5 ℃, crystallizing, filtering, washing a filter cake with water to be neutralDrying to obtain 3-amino-9, 13 b-dihydro-1H-dibenzo [ c, f ]]Imidazo [1,5-a ]]Aza derivatives
12. The method for synthesizing epinastine hydrochloride according to claim 4, wherein 100 parts of 6- (aminomethyl) -6, 11-dihydro-1H-dibenzo [ b, e ] is used in S2]Aza derivatives
Dissolving with 400 parts of dichloromethane of 300-portions, adding 30-40 parts of cyanogen bromide, stirring and reacting for 12-15H at 25-30 ℃, cooling to 0-5 ℃ after the reaction is finished, crystallizing, filtering, dissolving the cyanogen bromide in 300 parts of water of 200-portions to prepare a suspension, adjusting the pH value to 10-11 with 10 percent NaOH solution, stirring for 2-3H, cooling to 0-5 ℃, crystallizing, filtering, washing a filter cake with water to be neutral, and drying to obtain the 3-amino-9, 13 b-dihydro-1H-dibenzo [ c, f ] with water]Imidazo [1,5-a ]]Aza derivatives
13. The method for synthesizing epinastine hydrochloride according to claim 6, wherein 100 parts of 6- (aminomethyl) -6, 11-dihydro-1H-dibenzo [ b, e ] is used in S2]Aza derivatives
Dissolving with 400 parts of dichloromethane of 300-portions, adding 30-40 parts of cyanogen bromide, stirring and reacting for 12-15H at 25-30 ℃, cooling to 0-5 ℃ after the reaction is finished, crystallizing, filtering, dissolving the cyanogen bromide in 300 parts of water of 200-portions to prepare a suspension, adjusting the pH value to 10-11 with 10 percent NaOH solution, stirring for 2-3H, cooling to 0-5 ℃, crystallizing, filtering, washing a filter cake with water to be neutral, and drying to obtain the 3-amino-9, 13 b-dihydro-1H-dibenzo [ c, f ] with water]Imidazo [1,5-a ]]Aza derivatives
14. The method for synthesizing epinastine hydrochloride according to claim 9, wherein 100 parts of 6- (aminomethyl) -6, 11-dihydro-1H-dibenzo [ b, e ] is used in S2]Aza derivatives
Dissolving with 400 parts of dichloromethane of 300-portions, adding 30-40 parts of cyanogen bromide, stirring and reacting for 12-15H at 25-30 ℃, cooling to 0-5 ℃ after the reaction is finished, crystallizing, filtering, dissolving the cyanogen bromide in 300 parts of water of 200-portions to prepare a suspension, adjusting the pH value to 10-11 with 10 percent NaOH solution, stirring for 2-3H, cooling to 0-5 ℃, crystallizing, filtering, washing a filter cake with water to be neutral, and drying to obtain the 3-amino-9, 13 b-dihydro-1H-dibenzo [ c, f ] with water]Imidazo [1,5-a ]]Aza derivatives
15. The method for synthesizing epinastine hydrochloride according to claim 1 or 2, wherein in the step S3, 3-amino-9, 13 b-dihydro-1H-dibenzo [ c, f ] is reacted]Imidazo [1,5-a ]]Aza derivatives
Adding into ethanol, stirring for dissolving, adding dropwise concentrated hydrochloric acid to adjust pH to 2-3, stirring, cooling, crystallizing, filtering, recrystallizing, filtering, and drying.
16. The method for synthesizing epinastine hydrochloride according to claim 1 or 2, wherein 100 parts of 3-amino-9, 13 b-dihydro-1H-dibenzo [ c, f ] is used in S3]Imidazo [1,5-a ]]Aza derivatives
Adding into 400-500 parts of ethanol, stirring for dissolving, dropwise adding concentrated hydrochloric acid to adjust the pH value to 2-3, stirring at room temperature for 3-5h, cooling to 0-5 ℃, crystallizing, filtering, recrystallizing the filter cake with 60% ethanol, filtering, and dryingAnd (5) obtaining the product.
17. The method for synthesizing epinastine hydrochloride according to claim 3, wherein 100 parts of 3-amino-9, 13 b-dihydro-1H-dibenzo [ c, f ] is used in S3]Imidazo [1,5-a ]]Aza derivatives
Adding into 400-500 parts of ethanol, stirring for dissolving, dropwise adding concentrated hydrochloric acid to adjust the pH value to 2-3, stirring at room temperature for 3-5h, cooling to 0-5 ℃, crystallizing, filtering, recrystallizing a filter cake with 60% ethanol, filtering, and drying to obtain the product.
18. The method for synthesizing epinastine hydrochloride according to claim 4, wherein 100 parts of 3-amino-9, 13 b-dihydro-1H-dibenzo [ c, f ] is used in S3]Imidazo [1,5-a ]]Aza derivatives
Adding into 400-500 parts of ethanol, stirring for dissolving, dropwise adding concentrated hydrochloric acid to adjust the pH value to 2-3, stirring at room temperature for 3-5h, cooling to 0-5 ℃, crystallizing, filtering, recrystallizing a filter cake with 60% ethanol, filtering, and drying to obtain the product.
19. The method for synthesizing epinastine hydrochloride according to claim 6, wherein 100 parts of 3-amino-9, 13 b-dihydro-1H-dibenzo [ c, f ] is used in S3]Imidazo [1,5-a ]]Aza derivatives
Adding into 400-500 parts of ethanol, stirring for dissolving, dropwise adding concentrated hydrochloric acid to adjust the pH value to 2-3, stirring at room temperature for 3-5h, cooling to 0-5 ℃, crystallizing, filtering, recrystallizing a filter cake with 60% ethanol, filtering, and drying to obtain the product.
20. The method for synthesizing epinastine hydrochloride according to claim 9, wherein 100 parts of 3-amino-9, 13 b-dihydro-1H-dibenzo [ c, f ] is used in S3]Imidazo [1,5-a ]]Aza derivatives
Adding into 400-500 parts of ethanol, stirring for dissolving, dropwise adding concentrated hydrochloric acid to adjust the pH value to 2-3, stirring at room temperature for 3-5h, cooling to 0-5 ℃, crystallizing, filtering, recrystallizing a filter cake with 60% ethanol, filtering, and drying to obtain the product.
21. The method for synthesizing epinastine hydrochloride according to claim 10, wherein 100 parts of 3-amino-9, 13 b-dihydro-1H-dibenzo [ c, f ] is used in S3]Imidazo [1,5-a ]]Aza derivatives
Adding into 400-500 parts of ethanol, stirring for dissolving, dropwise adding concentrated hydrochloric acid to adjust the pH value to 2-3, stirring at room temperature for 3-5h, cooling to 0-5 ℃, crystallizing, filtering, recrystallizing a filter cake with 60% ethanol, filtering, and drying to obtain the product.
22. The method for synthesizing epinastine hydrochloride according to claim 15, wherein 100 parts of 3-amino-9, 13 b-dihydro-1H-dibenzo [ c, f ] is used in S3]Imidazo [1,5-a ]]Aza derivatives
Adding into 400-500 parts of ethanol, stirring for dissolving, dropwise adding concentrated hydrochloric acid to adjust the pH value to 2-3, stirring at room temperature for 3-5h, cooling to 0-5 ℃, crystallizing, filtering, recrystallizing a filter cake with 60% ethanol, filtering, and drying to obtain the product.
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| WO2006044504A1 (en) * | 2004-10-13 | 2006-04-27 | Merck & Co., Inc. | Cgrp receptor antagonists |
| CN103172638A (en) * | 2013-03-13 | 2013-06-26 | 杨军 | Preparation method of epinastine hydrochloride |
| CN103509025A (en) * | 2012-06-29 | 2014-01-15 | 重庆药友制药有限责任公司 | Preparation method of epinastine hydrochloride and intermediate thereof |
| CN105153169A (en) * | 2014-11-27 | 2015-12-16 | 兆科药业（广州）有限公司 | Synthesis method for epinastine hydrochloride |
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| WO2006044504A1 (en) * | 2004-10-13 | 2006-04-27 | Merck & Co., Inc. | Cgrp receptor antagonists |
| CN103509025A (en) * | 2012-06-29 | 2014-01-15 | 重庆药友制药有限责任公司 | Preparation method of epinastine hydrochloride and intermediate thereof |
| CN103172638A (en) * | 2013-03-13 | 2013-06-26 | 杨军 | Preparation method of epinastine hydrochloride |
| CN105153169A (en) * | 2014-11-27 | 2015-12-16 | 兆科药业（广州）有限公司 | Synthesis method for epinastine hydrochloride |
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