CN108339157A - 一种可组装生物支架数字设计与3d打印制备方法 - Google Patents

一种可组装生物支架数字设计与3d打印制备方法 Download PDF

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CN108339157A
CN108339157A CN201710417024.0A CN201710417024A CN108339157A CN 108339157 A CN108339157 A CN 108339157A CN 201710417024 A CN201710417024 A CN 201710417024A CN 108339157 A CN108339157 A CN 108339157A
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孙玉春
周永胜
刘云松
王勇
陈科龙
李榕
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Nanjing Profeta Intelligent Technology Co ltd
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Peking University School of Stomatology
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Abstract

本发明涉及一种可组装生物支架数字设计与3D打印制备方法，有以下步骤：1)用CAD软件设计支架的整体外形；2)将支架整体分解为多个子部分；3)子部分设计为多孔结构；4)各子部分用3D打印机打印；5)将各子部分打印体分别消毒，然后分别加入不同细胞、生长因子；6)在无菌环境中，利用嵌套连接结构将各子部分连接为整体支架外形；7)将组装完成的支架在组织缺损区模型进行就位，即完成需要修复的组织缺损区的制备。本发明适于各类软硬组织的组织工程支架的3D打印制造，可规避直接活性细胞、生长因子打印时对活性的损伤，并可实现多种材料、多种结构以及多种活性因子的灵活组合应用。

Description

一种可组装生物支架数字设计与3D打印制备方法
技术领域
本发明涉及一种软硬组织的组织工程支架的3D打印制造，具体涉及一种可组装生物支架数字设计与3D打印制备方法。
背景技术
既往研究多采用多喷头打印机一体化设计与打印，往往只能打印一种性状的材料，不适合于形状差异很大的多材料打印，例如金属与PCL，金属需要用激光烧结，而PCL需要熔积成形，原理上无法统一到单次打印过程中。
发明内容
为了克服以上不足，本发明专利提供一种可组装生物支架数字设计与3D打印制备方法，适于各类软硬组织的组织工程支架的3D打印制造，可规避直接活性细胞、生长因子打印时打印过程对活性的损伤，并可实现多种材料、多种结构以及多种活性因子的灵活组合应用。
为了达到上述目的，本发明有如下技术方案：
本发明的一种可组装生物支架数字设计与3D打印制备方法，有以下步骤：
1)扫描组织缺损区获取组织缺损区的形态数据，根据组织缺损区的形态，用CAD软件设计支架的整体外形；
2)将支架整体分解为多个子部分，各子部分之间设计嵌套连接结构；
3)子部分设计为多孔结构，设计为不同的孔隙率、孔隙直径和孔隙特征；
4)各子部分能应用不同的材料，用3D打印机和对应的材料分别打印各个子部分；
5)将各子部分打印体分别消毒，然后分别加入不同细胞、生长因子；
6)在无菌环境中，利用嵌套连接结构将各子部分连接为整体支架外形，将血管安装于各子部分预留的血管通道中，或将流动性血管支架材料直接注射入各子部分预留的血管通道中；
7)将组装完成的支架在组织缺损区模型进行就位精度检查，针对微细差别，对支架进行研磨调整或补缺调整，即完成需要修复的组织缺损区的制备。
其中，所述嵌套连接结构是各子部分上的若干个凸起和凹坑，将相邻的一个子部分的凸起插入另一个子部分的凹坑，形成嵌套连接结构，从而将各子部分连接为整体支架。
其中，所述孔隙特征是指孔隙的形状，孔隙的立体结构。
其中，所述孔隙的形状包括正方形、五边形、六边形、三角形或多边形；所述孔隙的立体结构包括若干个横梁制件和竖梁制件，横梁制件与竖梁制件之间，通过通过重叠黏附在一起；或者，横梁制件与竖梁制件之间，通过相互穿通交叉连接在一起；若干个横梁制件与竖梁制件连接在一起后，横梁制件与竖梁制件之间形成孔隙。
本发明的优点在于：
本发明适于各类软硬组织的组织工程支架的3D打印制造，可规避直接活性细胞、生长因子打印时打印过程对活性的损伤，并可实现多种材料、多种结构以及多种活性因子的灵活组合应用。
附图说明
图1为本发明相邻子部分嵌套连接结构的横截面示意图。
图中，1、凸起；2.凹坑；3、子部分一；4、子部分二。
具体实施方式
以下实施例用于说明本发明，但不用来限制本发明的范围。
参见图1，本发明的一种可组装生物支架数字设计与3D打印制备方法，有以下步骤：
1)扫描组织缺损区获取组织缺损区的形态数据，根据组织缺损区的形态，用CAD软件设计支架的整体外形；
2)将支架整体分解为多个子部分，各子部分之间设计嵌套连接结构；
3)子部分设计为多孔结构，设计为不同的孔隙率、孔隙直径和孔隙特征，各子部分设计留有能贯通各子部分的血管通道；
4)各子部分能应用不同的材料，用3D打印机和对应的材料分别打印各个子部分，以及与各子部分相适应的血管；
5)将各子部分打印体分别消毒，然后分别加入不同细胞、生长因子；
6)在无菌环境中，利用嵌套连接结构将各子部分连接为整体支架外形，将血管安装于各子部分预留的血管通道中；
7)将组装完成的支架在组织缺损区模型进行就位精度检查，针对微细差别，对支架进行研磨调整或补缺调整，即完成需要修复的组织缺损区的制备。
所述各子部分包括用3D打印机打印的骨、皮肤、粘膜、血管及神经各类软硬组织支架。
所述嵌套连接结构是各子部分上的若干个凸起和凹坑，将相邻的一个子部分的凸起插入另一个子部分的凹坑，形成嵌套连接结构，从而将各子部分连接为整体支架。
所述孔隙特征是指孔隙的形状，孔隙的立体结构。
所述孔隙的形状包括正方形、五边形、六边形、三角形或多边形；所述孔隙的立体结构包括若干个横梁制件和竖梁制件，横梁制件与竖梁制件之间，通过通过重叠黏附在一起；或者，横梁制件与竖梁制件之间，通过相互穿通交叉连接在一起；若干个横梁制件与竖梁制件连接在一起后，横梁制件与竖梁制件之间形成孔隙。
CAD：计算机辅助设计。
细胞、生长因子：根据修复缺损组织类型选择细胞及对应的生长因子。例如骨组织缺损修复时，常用的为脂肪间充质干细胞，骨髓间充质干细胞，骨形态发生蛋白(BMP)，血管内皮生长因子(VEGF)等。各子部分加入的量和种类根据诱导组织的种类决定。其中，脂肪间充质干细胞，骨髓间充质干细胞，骨形态发生蛋白(BMP)，血管内皮生长因子(VEGF)，既可以在市场上购置，也可以使用患者自身的细胞进行制备。
PCL，中文意思是聚己内酯，用作药物缓释系统。
聚己内酯具有良好的生物降解性、生物相容性和无毒性，而被广泛用作医用生物降解材料及药物控制释放体系，可运用于组织工程已经作为药物缓释系统。
步骤4)所述各子部分能应用不同的材料，包括钛合金、纯钛；PCL+HA；PLA+TCP，等等。其中，PCL+HA：聚己内酯+羟基磷灰石；PLA+TCP：聚乳酸+磷酸三钙。
步骤5)是将各子部分浸泡在细胞、生长因子的液体中，从而使各子部分分别获取细胞、生长因子。
如上所述，便可较为充分的实现本发明。以上所述仅为本发明的较为合理的实施实例，本发明的保护范围包括但并不局限于此，本领域的技术人员任何基于本发明技术方案上非实质性变性变更均包括在本发明包括范围之内。

Claims (4)

1.一种可组装生物支架数字设计与3D打印制备方法，其特征在于有以下步骤：
1)扫描组织缺损区获取组织缺损区的形态数据，根据组织缺损区的形态，用CAD软件设计支架的整体外形；
2)将支架整体分解为多个子部分，各子部分之间设计嵌套连接结构；
3)子部分设计为多孔结构，设计为不同的孔隙率、孔隙直径和孔隙特征；
4)各子部分能应用不同的材料，用3D打印机和对应的材料分别打印各个子部分；
5)将各子部分打印体分别消毒，然后分别加入不同细胞、生长因子；
6)在无菌环境中，利用嵌套连接结构将各子部分连接为整体支架外形，将血管支架安装于各子部分预留的血管通道中，或将流动性血管支架材料直接注射入各子部分预留的血管通道中；
7)将组装完成的支架在组织缺损区模型进行就位精度检查，针对微细差别，对支架进行研磨调整或补缺调整，即完成需要修复的组织缺损区的制备。
2.根据权利要求1所述的一种可组装生物支架数字设计与3D打印制备方法，其特征在于：所述嵌套连接结构是各子部分上的若干个凸起和凹坑，将相邻的一个子部分的凸起插入另一个子部分的凹坑，形成嵌套连接结构，从而将各子部分连接为整体支架。
3.根据权利要求1所述的一种可组装生物支架数字设计与3D打印制备方法，其特征在于：所述孔隙特征是指孔隙的形状，孔隙的立体结构。
4.根据权利要求3所述的一种可组装生物支架数字设计与3D打印制备方法，其特征在于：所述孔隙的形状包括正方形、五边形、六边形、三角形或多边形；所述孔隙的立体结构包括若干个横梁制件和竖梁制件，横梁制件与竖梁制件之间，通过通过重叠黏附在一起；或者，横梁制件与竖梁制件之间，通过相互穿通交叉连接在一起；若干个横梁制件与竖梁制件连接在一起后，横梁制件与竖梁制件之间形成孔隙。
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CN112957523A (zh) * 2021-02-09 2021-06-15 浙江大学 一种用于同步修复软硬组织缺损的仿生复合支架及其基于3d打印的成型方法

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WO2015103149A1 (en) * 2013-12-30 2015-07-09 The New York Stem Cell Foundation Tissue grafts and methods of making and using the same

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112957523A (zh) * 2021-02-09 2021-06-15 浙江大学 一种用于同步修复软硬组织缺损的仿生复合支架及其基于3d打印的成型方法
WO2022170820A1 (zh) * 2021-02-09 2022-08-18 浙江大学 一种用于同步修复软硬组织缺损的仿生复合支架的3d打印成型方法

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