CN108338816A - Holder release or its purposes of combination with medical guiding wire in electric thrombus treatment - Google Patents
Holder release or its purposes of combination with medical guiding wire in electric thrombus treatment Download PDFInfo
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- CN108338816A CN108338816A CN201710054112.9A CN201710054112A CN108338816A CN 108338816 A CN108338816 A CN 108338816A CN 201710054112 A CN201710054112 A CN 201710054112A CN 108338816 A CN108338816 A CN 108338816A
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- Prior art keywords
- electric
- purposes
- power supply
- aneurysm
- thrombus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
- A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
- A61B17/12113—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel within an aneurysm
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
Abstract
This application involves holder release or its purposes of combination with medical guiding wire in electric thrombus treatment.Device for electric thrombus treatment includes power supply, output seal wire, input seal wire, wherein output seal wire is connected to the anode of power supply, input seal wire is connected to the cathode of power supply.Holder release may be used as the power supply.The application further relates to purposes of the device in treatment of intracranial aneurysm.In addition, the application further relates to holder release and purposes of the Traxcess series seal wire in electric thrombosis, particularly aneurysm treatment.The application further relates to a kind of power supply being specifically used for electric thrombus.
Description
Technical field
This application involves a set of electricity treatment devices formed for inducing thrombosis and the device in treatment of intracranial aneurysm
In purposes.This application involves holder release (such as Solitaire holders release) and Traxcess series seal wire (such as
Traxcess-14 seal wires) purposes in electric thrombosis, particularly aneurysm treatment.The application further relates to a kind of specific use
In the power supply of electric thrombus.
Background technology
" electric thrombosis " this concept just occurred before twoth century, and principle is to utilize electric conduction material table
The positive charge in face attracts the negatively charged haemocyte in blood, blood platelet, coagulation factor etc. to form blood clot.1824,
Scudamore has found that anode electrode generates thrombus, and cathode electrode does not have thrombosis, has raised the research sequence of electric thrombosis
Curtain.1847, Ciniselli punctured aneurysm inducing thrombosis with Direct Current of Electrotherapy and is formed, and for the first time applies this technology in aneurysm
In the research for the treatment of.
However, with the progress of medical technology and the continuous promotion of human health demand, the limitation of electric thrombosis
Gradually it highlights.Mullan etc. makes in the intracranial aneurysm row check in postoperative 6 months of 12 electric thrombosis treatments of nineteen sixty-five pair
As a result shadow shows that electric thrombosis induced synthesis thrombus cannot be lasting, can only work temporarily, lasting aneurysm embolization is not achieved
Effect；At subsequent 1969, Mullan by research it is further noted that initial intracranial aneurysm inside points electricity thrombus not only
Cannot successfully aneurysm embolization within reasonable time, or even because changing the blood circulation stablized in aneurysm, more hold
Easily lead to aneurysmal subarachnoid hemorrhage.It can be seen that simple electricity thrombosis forms the unstability because of fresh thrombus, and immediately come
Fibrinolysis process, frequently result in the failure of electric thrombosis treatment intracranial aneurysm.To 2004, Henkes H etc. were by grinding
Study carefully Matrix detachable coil surface thrombosis, obtains electric thrombosis formation basic theory in electrolysis spring ring intracranial aneurysms embolization
In do not have certainty effect.Since then, the thinking that aneurysm embolism is realized by electric thrombosis is abandoned gradually in the industry, then
Use simple machinery filling for therapy in the conventional vascular of representative.Various embolization techniques and auxiliary embolism holder later
Rapid development, has more established the dominance of Coil embolization intracranial aneurysm.
Although being that the conventional embolization means of representative are closing artery knurl, inducing thrombosis formation art effect using Coil embolization
Certainly, but problems are also frequently encountered in clinical practice, including but not limited to：
1. small aneurysm (especially microtubular cannot be introduced into the aneurysm for staying chamber) clinically, the interior treatment of conventional vascular
Method is often not satisfactory；
2. for bleeding blister sample aneurysm, embolotherapy is undesirable in conventional vascular, and the expenses such as close net holder are too high and right
Path vascular conditions require high；
3. for large aneurysm, conventional embolization is commonly encountered tumor neck remnants, is difficult to reach Dense embolization, and holder auxiliary is also difficult to
Reach Dense embolization, usually recurs quickly；Close net holder is although feasible, somewhat expensive.
4. rolling into a ball internal aneurysm for smoke-like blood vessel and arteriovenous malformation (AVM) rolling into a ball internal aneurysm, treated in conventional vascular
It is often difficult to retain tiny feeding artery around in the process, it is postoperative to lead to patient's blood supply insufficiency.
In conclusion even to this day, for the aneurysm that the treatment of traditional interventional therapy method is difficult, still needing one in the industry
Effective, convenient, the lasting thrombus abductive approach of kind, to bring better treatment for such aneurysm patient.
Innovation and creation content
For the aneurysm that the treatment of traditional interventional therapy method is difficult, other are found one after another in other insiders and new is controlled
When treatment approach, present inventor but unexpectedly starts with from the electric thrombosis being abandoned and is improved this,
A kind of method effective for thrombus has been found out, and people's will is carried out out using the material for being originally used for other purposes in the art
The combination of material, to devise the device for preceding method.The method and device are not only able to form thrombus well, and
And it is easy, easy, the problem of the effect of thrombus can be made lasting, well solved aforementioned background art.
In an aspect, this application involves a kind of method being used to form thrombus, this approach includes the following steps：
1. electric thrombus step.Using in a certain range of constant-current dc electric attraction blood leucocyte, blood platelet, blood coagulation because
The negatively charged factor such as son, inducing thrombosis are formed；
2. thrombus organization step.Thrombosis is further promoted to accelerate, be denaturalized, machine using electrocaloric effect, it will be unstable
Thrombus is transformed into stable thrombus.
In another aspect, this application involves a kind of devices for putting into practice the above method.The basic structure of the device
As shown in Figure 1, including power supply and guide wire portion (or being made of power supply and guide wire portion).Power supply 1 provides constant current, by defeated
Go out seal wire 2 and conduct electrical currents to aneurysm from power anode 3 and formed with inducing thrombosis, while so that thrombus is denaturalized using electrocaloric effect
Machine is changed into stable thrombus.Hereafter, electric current flows into power cathode 5 by inputting seal wire 4 again, to be formed into a loop.Power supply 1
The power supply mode of itself is unlimited, can both be powered by the direct current of battery etc, can also be by accessing external communication electricity
The mode that source is then converted to direct current is powered.The apolegamy of taking up an official post of power supply 1 has one or more panels 6 to show the parameters such as electric current, voltage.
The present processes and device convenient material drawing, it is simple and practicable.It can increase due to the stimulation without machinery filling
Blood clot volume is added, to reduce in ruptured aneurysm endovascular treatment art, recurrent bleeding factor；In particular, this Shen
Method and apparatus please make microtubular or micro-wire be confined in aneurysm, reduce because blood flow paths are tortuous, support force not
Risk and difficulty that operation is brought are complicated caused by enough.In addition, on the basis of thrombosis the denaturation of further inducing thrombosis and
Machine, prevents Fibrinolysis process, and stablizing thrombus reduces the chance of ruptured aneurysm secondary rupture haemorrhage in the recent period.Meanwhile
The present processes and device save a large amount of expenses, are even more important for the patient in the weak area of economic force.
Special power supply and seal wire had both may be used in the application, can also use Solitaire holders common on the market
Release and Traxcess-14 seal wires are used separately as power supply and seal wire.Although the purposes of the two script has no bearing on electric thrombus,
But applicant have been surprisingly found that the purpose of electric thrombus can be well realized in the combination of the two.The another aspect of the application relates to
And holder release (such as Solitaire holders release) and Traxcess series seal wire (such as Traxcess-14 seal wires)
And combinations thereof preparing for the purposes in the device of electric thrombus.
In addition, in another embodiment, applicant devises a kind of constant-current supply, it is dedicated as the application electricity blood
Bolt for electric installation.The power supply is the electric current needed for resistance based on human body and electric thrombus and particular design, the prior art
In the electricity that can also export electric current needed for electric thrombus power supply as designed by the application after being connected with human body is also not present
Source.
Description of the drawings
Fig. 1：The schematic device of the application.
Fig. 2：A kind of circuit diagram of power supply for the application.
Fig. 3 A：The radiography figure of case 1 sticked after intracranial stent.
Fig. 3 B：Case 1 uses the radiography figure of seal wire.
Fig. 3 C：Case 1 is powered 3 radiography figures after six minutes totally through Solitaire holder releases.
Fig. 3 D：The DSA images that case 1 is checked through electricity treatment after 6 months.
Fig. 4 A：The radiography figure of the preoperative basal arteries perforating branches microaneurysm of the electric thrombus of case 2.
Fig. 4 B：Case 2 is powered 3 radiography figures after six minutes totally through Solitaire holder releases.
Fig. 5 A：The preoperative radiography figure of the electric thrombus of case 3.
Fig. 5 B：Case 3 is powered 3 radiography figures after six minutes totally through Solitaire holder releases.
Specific implementation mode
As it was noted above, the device of the application includes power supply and guide wire portion (or being made of power supply and guide wire portion).
Commercially available constant-current supply or constant voltage source may be used in power supply.Applicant has found constant-current supply phase in clinical practice
Than having the advantage of bigger in constant voltage source：Although constant voltage source can provide constant output voltage, due to everyone people
Bulk resistor all has individual difference and cannot keep stable constantly, can influence the stabilization of electric current and controllable output.And Constant Electric Current
Source can directly provide constant electric current, be more conducive to the stability of thrombosis external condition and the controllability of heat.
In a specific embodiment, the output current of the power supply is about 0.1-50mA, 0.2-20mA, 0.5-
10mA, 0.8-5mA.In another embodiment, the output current of the power supply be about 0.8mA, 1mA, 1.5mA,
2mA, 3mA or 5mA.
Applicant has also been unexpectedly found that commercially available holder release may be used as the power supply of the application, such as
Solitaire holder releases.Holder release is mainly used for freeing for holder using electrolysis principle, in general medical practice
In have no to be associated with thrombosis.However, present inventor have been surprisingly found that it can be conducive to the electricity of the application
It is especially relative constant because it has the voltage (for example, about 9V) of stable safety during the energization in thrombosis method
Electric current (for example, about 0.8-1.0mA).Therefore, further aspect of the application is related to holder release (such as Solitaire holders
Release) in the purposes for the purposes in electric thrombus treatment, and in preparing the device for thrombosis.
Other than holder release " part performing " power supply may be used, other suitable power supplys can also be used.For example, this
The inventor of application devises a kind of power supply, which includes following elements：Internal electric source, voltage-stablizer, diode, the first electricity
Resistance, second resistance, 3rd resistor, the first rheostat, ammeter, external electrode and the second rheostat.Wherein internal electric source is constituted
Power pack, voltage-stablizer, diode, first resistor, second resistance and 3rd resistor constitute flow control part, the first rheostat and the
Two rheostats, which are constituted, adjusts part, and ammeter and external electrode constitute output par, c.Adjust in part optionally further includes that gear turns
Parallel operation, so that electric current switches between different stalls, to consistently export corresponding electric current.In view of the subcutaneous resistance of human body
500 Ω are usually no more than, can determine each resistance and rheostatic Standard resistance range as described below.
In power pack, internal electric source can directly use DC power supply, or by the way that external alternating current is converted into direct current
Electricity is powered to form DC power supply.The DC output voltage of power supply can be about 10V, 12V, 14V, 16V, 18V, 20V, 22V,
24V, 26V, 28V, 30V, 32V, 34V, 36V, 38V or 40V, for example, by using 24V DC power supplies.
In flow control part, market may be used for ensuring that output par, c circuit voltage is metastable in voltage-stablizer
Upper common three terminal regulator, such as LM117HVH three terminal regulators.The output end of voltage-stablizer separates two and is separately connected
First resistor for partial pressure and the 3rd resistor for current limliting.Why need setting for current limliting 3rd resistor, be because
It is widely different for different life entity resistance values, it is also possible to cause current variation excessive, therefore for needing to be arranged herein for the sake of safety
Current-limiting resistance.The resistance value of first resistor can be about 200 Ω, 220 Ω, 230 Ω, 250 Ω, 280 Ω, 300 Ω, 320 Ω, 330 Ω,
350 Ω, 380 Ω or 400 Ω.The resistance value of 3rd resistor can be about 500 Ω, 1000 Ω, 1500 Ω, 2000 Ω, 2500 Ω, 3000
Ω, 3500 Ω or 4000 Ω.
In addition, diode is connected to the third end of voltage-stablizer and connects with second resistance, for protecting voltage-stablizer because of output
Terminal voltage is excessively high and damages.Specifically, when output end of voltage stabilizer is connected to very bulky capacitor and input terminal keeps voltage capability smaller
When, the case where output end current potential is higher than input terminal is just will appear after power-off, it is therefore desirable to which diode is set so that its output end is electric
Hold to input terminal and discharge, protects voltage-stablizer.According to adjust electric current needs, can by one or more diodes (such as one,
Two or three) it is cascaded.The resistance value of second resistance can be about 5 Ω, 10 Ω, 15 Ω, 20 Ω, 25 Ω, 30 Ω, 35 Ω or
40Ω。
Adjust in part, the first rheostat connect with 3rd resistor and formed jointly with the second rheostat it is in parallel, described the
One rheostat for adjusting electric current on a large scale between different life entities (such as between different patients).First is rheostatic
Maximum value can be about 5k Ω, 5.5k Ω, 6k Ω, 6.5k Ω, 7k Ω, 7.5k Ω, 8k Ω, 8.5k Ω, 9k Ω, 9.5k
Ω、10kΩ、10.5kΩ、11kΩ、11.5kΩ、12kΩ、12.5kΩ、13kΩ、13.5kΩ、14kΩ、14.5kΩ、15k
Ω.First rheostat can have several (such as three) gears, the resistance value of each gear about can be 0.5k Ω, 1k Ω,
1.5kΩ、2kΩ、2.5kΩ、3kΩ、3.5kΩ、4kΩ、4.5kΩ、5kΩ、5.5kΩ、6kΩ、6.5kΩ、7kΩ、7.5k
Ω、8kΩ、8.5kΩ、9kΩ、9.5kΩ、10kΩ、10.5kΩ、11kΩ、11.5kΩ、12kΩ、12.5kΩ、13kΩ、
13.5kΩ、14kΩ、14.5kΩ、15kΩ。
Second rheostat is used to be finely adjusted electric current when life entity small range fluctuate (such as to same patient progress
When operation).Second rheostatic maximum value can be about 10k Ω, 11k Ω, 12k Ω, 13k Ω, 14k Ω, 15k Ω, 16k
Ω、17kΩ、18kΩ、19kΩ、20kΩ、21kΩ、22kΩ、23kΩ、24kΩ、25kΩ、26kΩ、27kΩ、28kΩ、
29k Ω or 30k Ω.Second rheostat can also have several (such as three) gears, the resistance value of each gear about can be 1k Ω,
2kΩ、3kΩ、4kΩ、5kΩ、6kΩ、7kΩ、8kΩ、9kΩ、10kΩ、11kΩ、12kΩ、13kΩ、14kΩ、15kΩ、
16kΩ、17kΩ、18kΩ、19kΩ、20kΩ、21kΩ、22kΩ、23kΩ、24kΩ、25kΩ、26kΩ、27kΩ、28k
Ω, 29k Ω or 30k Ω.
It includes gear converter to adjust in part, connected with the first rheostat and 3rd resistor, by that will control
Switching toggle processed realizes the function of electric current gear switch to different stalls, gear number can there are two, three, four or five
Etc..Wherein, each gear itself connects certain resistance to adjust electric current in the range of aforementioned output current, the resistance
Resistance value size it is related with 3rd resistor and the first rheostat, it is also related from the resistance of different life entities itself.For example, can will be every
The resistance of a gear connection is for example respectively set to about 0k Ω, 0.3k Ω, 0.5k Ω, 1k Ω, 2k Ω, 3k Ω, 4k Ω, 5k
Ω、6kΩ、7kΩ、8kΩ、9kΩ、10kΩ、11kΩ、12kΩ、13kΩ、14kΩ、15kΩ、16kΩ、17kΩ、18kΩ、
19k Ω, 20k Ω, 21k Ω, 22k Ω, 23k Ω, 24k Ω, 25k Ω, 26k Ω, 27k Ω, 28k Ω, 29k Ω or 30k Ω, to
Output current is controlled in about 0.5mA, 1mA, 1.5mA, 2mA, 2.5mA, 3mA, 3.5mA, 4mA, 4.5mA or 5mA.
In output par, c, ammeter is ammeter commonly used in the trade, the electric current being used to indicate in electric thrombus operation, Ke Yizuo
For a part for panel 6 described previously.Its range ability is consistent with the common current range of electric thrombus, for example, 0-5mA, 0-
10mA, 0-20mA or 0-50mA etc., when use, can adjust the first rheostat and/or the second variable resistance according to the registration of ammeter
Device.External electrode then corresponds to aforesaid anode 3 and cathode 5.Ammeter and external electrode and the first rheostat and 3rd resistor string
Connection.
For aforementioned power source, Fig. 2 gives a kind of specific embodiment.Internal electric source is 24V DC power supplies, and output end connects
Two concatenated LM117HVH three terminal regulators U1 and U2 are met, the output end of U2 separates two and is separately connected first resistor R1 (330
Ω) and 3rd resistor R6 (2000 Ω).In addition one end of U2 is connected in series with two diode D1 and D2 and second resistance R5 (20
Ω), current feedback is made to enter U1, to play protective action to U1 and U2.First rheostat R2, gear converter, ammeter
XMM1 and external electrode are connected with 3rd resistor R6, and the series circuit forms in parallel, the first rheostat with the second rheostat R3
The maximum value of R2 is that the maximum value of 10k Ω, the second rheostat R3 are 20k Ω.Gear converter divides third gear, every grade of difference
Resistance R4, R7, R8 are connected, to make output current be respectively about 1mA, 2mA and 5mA.
In addition, clinically used seal wire may be used in the output seal wire of the application.Preferably, which has energization performance
Well, heat production is moderate and the head end of resistance to electrolysis.
Present inventor is surprisingly it has been found that commercially available Traxcess series seal wire, such as Traxcess-14 are led
Silk, is highly suitable as the output seal wire of the application.Traxcess seal wires are only used in the blood vessels coordinating in general manner micro- originally
Conduit is diagnosed or is treated, but without any report for using it for thrombosis.Since it is with good energization performance
And resistance to electrolysis ability is superpower, and (such as 140cm of the Traxcess-14 guidewire proximals in addition to tail end about 3cm has insulating coating, profit
Concentrated in positive charge head-end, the covering of head end inertia platinum coil), it is consequently adapted to be used as in the electric thrombosis method of the application
The seal wire of energization.Therefore, further aspect of the application be related to Traxcess seal wires, particularly Traxcess-14 seal wires with
Purposes in electric thrombus treatment, and preparing for the purposes in the device of electric thrombus.
Testing temperature optionally is installed in the output seal wire (such as in head end) of the application or for the device of temperature alarming,
And/or the auxiliary device for introducing microtubular.
Clinically used seal wire, such as common Medical power or holder solution may be used in input seal wire used herein
The conducting wire carried on the electrode of de- device may act as input seal wire.The syringe needle that input seal wire can connect metal is pricked in people
Body is subcutaneous (such as thigh is subcutaneous), or input seal wire is tied up in the appropriate location of human body, can also be attached to skin by patch
On, to realize circuit communication, forming circuit with human body.It is subcutaneous in the case that not penetrating, it should be noted that the resistance of human body itself
Value can become larger, and to ensure appropriate electric current, should correspondingly adjust the parameter of power supply, such as voltage and internal resistance etc..
The application further relates to Solitaire holders release and the combination of Traxcess-14 seal wires is used for electric thrombus treatment
In purposes, and the purposes in preparing thrombosis device.
Embodiment
Following case is treated using the present processes and device, is conventional treatments aneurysm difficult to treat,
Postoperative immediate effect and check effect are very ideal.
Material and method
Using a commercially available Traxcess-14 seal wire as output seal wire, tail end (i.e. uncoated conductive one end) connects
On the anode of Solitaire holder releases, the super choosing of seal wire head end to aneurysm cavity, tumor neck is with nearly all guide wire portions in vivo
It is isolated in except blood circulation range by microtubular；A piece syringe needle (is capable of the metal needle of conduction, such as commonly in thigh
Syringe needle) it is pierced into subcutaneously, and (serve as input to lead with the conducting wire on the power cathode of Solitaire holder releases
Silk) it connects, such positive charge collects at aneurysm cavity, and electric current returns to release by the subcutaneous resistance of human body through thigh syringe needle
Cathode, to form complete circuit (identical with holder principle is freed).
When being operated, seal wire head end is surpassed and is selected into aneurysm cavity, tumor neck proximal end whole process is protected with microtubular, is connected
To realize that electric thrombus operates, interruption is powered the power supply of Solitaire holder releases, and current control is in 1mA or so when energization.3
Secondary is a stage, radiography after a stage, until good results.
Case describes
Case 1：Male, 15 years old, tumble injury by motorcycle.The multiple dissecting aneurysm of bilateral carotid arteries, false aneurysm.Using
Aforesaid operations, for the unapproachable simple electricity treatment of false aneurysm row of microtubular.
Therapeutic process is as shown in figs. 3 a-3d.Fig. 3 A are shown at ophthalmic artery section false aneurysm stick intracranial stent after still
Development, and conventional microtubular can not pass through mesh.Fig. 3 B, which are shown, uses Traxcess-14 seal wires, and head end can reach tumor chamber, micro-
Conduit also can be at stent mesh.Fig. 3 C show that Solitaire holder releases are powered 3 times and show tumor chamber after totally six minutes
Development unobvious, show to form electric thrombus well.Fig. 3 D are the DSA images that electricity treatment is checked after 6 months, show electric thrombus
Be kept as very well, illustrate the device and method of the application be formed by thrombus have the effect of it is lasting.
Case 2：Male, 49 years old, because subarachnoid hemorrhage (SAH) is admitted to hospital.As the radiography of Fig. 4 A shows there is base at arrow
The small false aneurysm of bottom perforator artery.Since aneurysm is small, conventional microtubular is difficult to enter, therefore uses aforesaid operations
Carry out electricity treatment.Solitaire holder releases, which are powered 3 times, shows tumor chamber development unobvious totally after six minutes, as shown in Figure 4 B,
Show equally well to form electric thrombus.
Case 3：Women, 51 years old, headache, vomiting 10 days.Head CT shows bridge forebay, cisterna ambiens, Fourth ventricule hematocele；Head
CTA shows that there are basal arteries to do extremely small aneurysm.The aneurysmal radiography is as shown in Figure 5A.Solitaire holder solutions
De- device, which is powered 3 times, shows that tumor chamber development unobvious show equally well to form electric blood as shown in Figure 5 B totally after six minutes
Bolt.
Above-described embodiment is only used for illustrating or illustrating the technical solution of the application, should not be construed as appointing the composition of the application
What is limited.If making any improvement and modification for not spending creative work to the application, also should be regarded as falling the model in the application
Within enclosing.
Claims (6)
1. holder release is being prepared for the purposes in the device of electric thrombus treatment.
2. the combination of holder release and medical guiding wire is being prepared for the purposes in the device of electric thrombus treatment.
3. the purposes of claim 2, wherein the medical guiding wire is Traxcess seal wires.
4. the purposes of Claims 2 or 3, wherein the medical guiding wire is Traxcess-14 seal wires.
5. the purposes of any one of claim 1-4, wherein the holder release is Solitaire holder releases.
6. the purposes of any one of claim 1-5, wherein the electricity thrombus treatment is for treating aneurysm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710054112.9A CN108338816B (en) | 2017-01-22 | 2017-01-22 | Use of stent releasers or their combination with medical guide wires in the treatment of electro-thrombosis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710054112.9A CN108338816B (en) | 2017-01-22 | 2017-01-22 | Use of stent releasers or their combination with medical guide wires in the treatment of electro-thrombosis |
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| Publication Number | Publication Date |
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| CN108338816A true CN108338816A (en) | 2018-07-31 |
| CN108338816B CN108338816B (en) | 2020-06-26 |
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| US20080312645A1 (en) * | 2007-02-05 | 2008-12-18 | Boston Scientific Scimed, Inc. | Vascular Sealing Device and Method Using Clot Enhancing Balloon and Electric Field Generation |
| CN104665965A (en) * | 2013-11-29 | 2015-06-03 | 赛诺医疗科学技术有限公司 | Medical instrument release device and medical instrument release method |
| CN105363117A (en) * | 2014-08-08 | 2016-03-02 | 柯惠有限合伙公司 | Electrolytic detachment elements for implant delivery systems |
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