CN108329242A - A kind of isopropyl ester technology of threonates - Google Patents
A kind of isopropyl ester technology of threonates Download PDFInfo
- Publication number
- CN108329242A CN108329242A CN201710041705.1A CN201710041705A CN108329242A CN 108329242 A CN108329242 A CN 108329242A CN 201710041705 A CN201710041705 A CN 201710041705A CN 108329242 A CN108329242 A CN 108329242A
- Authority
- CN
- China
- Prior art keywords
- isopropyl ester
- threonates
- good
- sodium hydroxide
- added dropwise
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
A kind of isopropyl ester technology of threonates, isopropyl ester salt are important medicine intermediate, are production malotilates（Drug）Important raw and processed materials, belong to fine chemistry industry, production chains are good, of low cost, and market capacity is big, prepare it is simple, it is good in economic efficiency.For modified technique route of the present invention by the way of sodium hydroxide is added dropwise, it is to reduce labor intensity to improve conversion ratio all.
Description
Technical field
The present invention relates to chemical production fields, especially isopropyl ester salt production field.
Background technology
Isopropyl ester salt is important medicine intermediate, is production malotilate（Drug）Important raw and processed materials, belong to fine
Chemical industry, production chains are good, of low cost, and market capacity is big, prepare simply, good in economic efficiency.The disadvantage of traditional technology：1, anti-
Long between seasonable, raw material reaction is incomplete；2, solvent usage amount is big, and recycling design environmental protection treatment is of high cost；3, product centrifugal process
The middle a large amount of smog of generation, execute-in-place bad environments, labor intensity are big.
Invention content
The present invention uses advanced technologies, and by the way of sodium hydroxide is added dropwise, it is to reduce labor intensity to improve conversion ratio all.
Technological process：The carbon disulfide and Diisopropyl malonate measured is added in a kettle, after stirring and dissolving, in 17~20 DEG C
50% sodium hydroxide solution is added dropwise, after the completion of reaction, obtains product isopropyl ester salt.
Reaction equation：C9H16O4 + 2NaOH+ CS2 → C10H14O4S2Na2 + 2H2O。
Claims (3)
1. the present invention relates to technological processes：The carbon disulfide and Diisopropyl malonate measured is added in a kettle, stirs
After dissolving, 50% sodium hydroxide solution is added dropwise in 17~20 DEG C, after the completion of reaction, obtains product isopropyl ester salt.
2. the material composition and proportioning of claim 1.
3. the reactive mode of the sodium hydroxide solution that 50% is added dropwise in 17~20 DEG C of claim 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710041705.1A CN108329242A (en) | 2017-01-20 | 2017-01-20 | A kind of isopropyl ester technology of threonates |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710041705.1A CN108329242A (en) | 2017-01-20 | 2017-01-20 | A kind of isopropyl ester technology of threonates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108329242A true CN108329242A (en) | 2018-07-27 |
Family
ID=62922135
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710041705.1A Pending CN108329242A (en) | 2017-01-20 | 2017-01-20 | A kind of isopropyl ester technology of threonates |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108329242A (en) |
-
2017
- 2017-01-20 CN CN201710041705.1A patent/CN108329242A/en active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20180727 |
|
| WD01 | Invention patent application deemed withdrawn after publication |