CN108324843A - Chinese medicine composition and preparation method thereof for treating nephrosis - Google Patents
Chinese medicine composition and preparation method thereof for treating nephrosis Download PDFInfo
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- CN108324843A CN108324843A CN201810474211.7A CN201810474211A CN108324843A CN 108324843 A CN108324843 A CN 108324843A CN 201810474211 A CN201810474211 A CN 201810474211A CN 108324843 A CN108324843 A CN 108324843A
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Abstract
The present invention relates to a kind of Chinese medicine compositions and preparation method thereof for treating nephrosis, and the raw material components of Chinese medicine composition include Radix Notoginseng, rhizoma alismatis, radix rehmanniae preparata, Radix Codonopsis, earthworm, umbellate pore furgus, Chinese yam, safflower, radix pseudostellariae, Wu Dou, fructus corni, Cortex Phellodendri, leech, Radix Ophiopogonis, stone reed and Sculellaria barbata etc.；Preparation method includes step：It is mixed after earthworm, radix pseudostellariae, Cortex Phellodendri and leech are crushed, is then placed in water and impregnates, mixture after being impregnated；Other surplus stock components are crushed, mixture after impregnating then are added, then extract；It is filtered after extraction, collects filtrate；Filtrate is concentrated, Chinese medicine composition is obtained.The Chinese medicine composition that the present invention is prepared has effects that treat nephrosis, the especially significant effect for the treatment of diabetic nephropathy, easy to use, and without side-effects, the use of conventional medicament that can be larger to avoid side effect and undesirable therapeutic effect of safety；Preparation method is simple, and production cost is low.
Description
Technical field
The present invention relates to field of medicine preparing technology, and in particular to a kind of Chinese medicine composition and its system for treating nephrosis
Preparation Method.
Background technology
Nephrosis is the general designation of all kidney troubles, and there are many kinds of kidney troubles, can behave as the different lassitude and weak of degree,
Hypertension, albuminuria, the puffiness of the eyes, anaemia, pruitus, nausea and vomiting, electrolyte disturbance, acid poisoning, serum creatinine, urea nitrogen
Increase etc..The uremia later stage can involve the vital organs of the human body, or even hydropericardium and pleural effusion occur, cause the heart, lung, kidney three dirty
Functional failure.Moreover the easy sing misdiagnosis and mistreatment of this sickly look makes the state of an illness more delay refractory.The type of nephrosis is various, as acute and chronic kidney is small
Ball ephritis, concealment type ephritis, anaphylactoid purpura kidney, pyelonephritis etc. and various nephrosis, such as IgA nephrosis, membranous type nephrosis, renal is high
Blood pressure, lupus erythematosus kidney, gout kidney, diabetic nephropathy, nephrotic syndrome and uronephrosis, renal cyst, congenital polycystic kidney etc..
Later stage can develop into renal failure uremia.This disease in traditional medicine more to be belonged to strangurias, quenches one's thirst, consumptive disease, oedema, obstruction and rejection
Scope.Treatment to nephrosis, at present treatment of the doctor trained in Western medicine to various ephritis, nephrosis, nephrotic syndrome, mostly uses hormonotherapy, but
Hormone is stronger to the masking property of the state of an illness, and side effect is apparent, and easily recurrence；And responding well to treatment for Chinese medicine is slow, curative effect is undesirable.Cause
This, it is also necessary to develop novel drug.
Invention content
For the defects in the prior art, present invention aims at provide it is a kind of for treat nephrosis Chinese medicine composition and
Preparation method, as raw material and to carry out scientific matching using Radix Notoginseng, rhizoma alismatis, radix rehmanniae preparata etc., the Chinese medicine composition being prepared
Have effects that treat nephrosis, especially treats the significant effect of diabetic nephropathy, it is easy to use, and safety is without side-effects, it can
To avoid the use for the conventional medicament that side effect is larger and therapeutic effect is undesirable.
To achieve the above object, technical solution provided by the invention is：
The present invention provides a kind of for treating the Chinese medicine composition of nephrosis, raw material components by weight, including：Radix Notoginseng
20~30 parts by weight, 10~25 parts by weight of rhizoma alismatis, 20~30 parts by weight of radix rehmanniae preparata, 15~20 parts by weight of Radix Codonopsis, 20~30 weight of earthworm
Measure part, 10~20 parts by weight of umbellate pore furgus, 20~30 parts by weight of Chinese yam, 10~20 parts by weight of safflower, 20~30 parts by weight of radix pseudostellariae, crow
10~15 parts by weight of beans, 20~30 parts by weight of fructus corni, 25~35 parts by weight of Cortex Phellodendri, 10~25 parts by weight of leech, Radix Ophiopogonis 15~25
25~35 parts by weight of parts by weight, 15~25 parts by weight of stone reed and Sculellaria barbata.
Preferably, the raw material components of Chinese medicine composition further include：20~30 parts by weight of Radix Astragali, 10~30 parts by weight of dry toad,
20~30 parts by weight of Rhizoma Atractylodis Macrocephalae, 20~30 parts by weight of 15~25 parts by weight of RADIX MORINDAE OFFICINALIS, 20~30 parts by weight of Herba Lespedezae Cuneatae and Radix Glycyrrhizae.
Preferably, the raw material components of Chinese medicine composition by weight, including：25 parts by weight of Radix Notoginseng, 17 parts by weight of rhizoma alismatis,
23 parts by weight of radix rehmanniae preparata, 17 parts by weight of Radix Codonopsis, 24 parts by weight of earthworm, 16 parts by weight of umbellate pore furgus, 23 parts by weight of Chinese yam, 16 weight of safflower
Part, 27 parts by weight of radix pseudostellariae, 11 parts by weight of black beans, 22 parts by weight of fructus corni, 30 parts by weight of Cortex Phellodendri, 19 parts by weight of leech, Radix Ophiopogonis 21
Parts by weight, 17 parts by weight of stone reed, 31 parts by weight of Sculellaria barbata, 26 parts by weight of Radix Astragali, 20 parts by weight of dry toad, 24 parts by weight of Rhizoma Atractylodis Macrocephalae, bar
27 parts by weight of 19 parts by weight of halberd meat, 24 parts by weight of Herba Lespedezae Cuneatae and Radix Glycyrrhizae.
The present invention also provides the preparation methods of Chinese medicine composition, including step：By earthworm, radix pseudostellariae, Cortex Phellodendri and leech
It is mixed after crushing, is then placed in water and impregnates, mixture after being impregnated；Other surplus stock components are crushed, are then added
Mixture after immersion, then extract；It is filtered after extraction, collects filtrate；Filtrate is concentrated, Chinese medicine composition is obtained.
Preferably, in the preparation method of Chinese medicine composition, it is extracted as refluxing extraction, time of refluxing extraction is 160~
180min。
Preferably, in the preparation method of Chinese medicine composition, the temperature of immersion is 45~50 DEG C, time of immersion is 120~
150h。
Preferably, in the preparation method of Chinese medicine composition, the addition of water is the 25~30 of all raw material components gross masses
Times.
Preferably, in the preparation method of Chinese medicine composition, when Chinese medicine composition is measured at 25 DEG C relative density be 1.05~
1.10。
The present invention also protects application of the Chinese medicine composition in the drug and/or medicated premix for preparing treatment nephrosis.
It should be noted that the application method of the Chinese medicine composition for the treatment nephrosis that the present invention is prepared is preferably：Often
It is secondary to take 10~15g, it takes in the morning and evening daily, it is directly oral；Time of Administration can be adjusted according to the state of an illness.
Chinese medicine composition prepared by the above method can be further prepared into pharmaceutically acceptable dosage form as needed.This
Outside, protection scope of the present invention is also belonged to as drug made of active constituent using above-mentioned Chinese medicine composition.By by said medicine
Composition is prepared after directly preparing or being added pharmaceutically acceptable auxiliary material, can be made into any pharmaceutically acceptable dosage form.
Include by taking external preparation as an example：Solution, patch, vina, tincture, gelling agent, liniment, aerosol, spray, ointment and painting
Film.The drug of above-mentioned various dosage forms can be prepared according to the conventional method of pharmaceutical field.
Technical solution provided by the invention has following advantageous effect：(1) present invention is using Radix Notoginseng, rhizoma alismatis, radix rehmanniae preparata etc.
As raw material and scientific matching is carried out, the Chinese medicine composition being prepared has effects that treat nephrosis, especially treats glycosuria
The significant effect of sick nephrosis, it is convenient to take, any Western medicine hormonal components are not added, and safety is without side-effects, can make to avoid pair
With the use of larger and undesirable therapeutic effect conventional medicament；(2) Chinese medicine composition that the present invention is prepared, stability
By force, long shelf-life, drug effect will not be affected after preserving several years；(3) preparation method provided by the invention can be released fully
The active ingredient in raw medicinal material is put, so that the Chinese medicine composition being prepared possesses good drug effect, and is easy to absorb；
Preparation method is simple, and production cost is low, solves the problems, such as that treatment nephrosis is difficult, has good application prospect.
The additional aspect and advantage of the present invention will be set forth in part in the description, and will partly become from the following description
Obviously, or practice through the invention is recognized.
Specific implementation mode
Below in conjunction with the embodiment of the present invention, technical scheme of the present invention is clearly and completely described.Implement below
Example is only used for clearly illustrating technical scheme of the present invention, therefore be intended only as example, and cannot limit this hair with this
Bright protection domain.
Experimental method in following embodiments is unless otherwise specified conventional method.Examination as used in the following examples
Material is tested, is to be commercially available from regular shops unless otherwise specified.Quantitative test in following embodiment, is respectively provided with three
Secondary to repeat to test, data are the average value or mean+SD of three repeated experiments.
Radix Notoginseng as used in the following examples, rhizoma alismatis, radix rehmanniae preparata, Radix Codonopsis, earthworm, umbellate pore furgus, Chinese yam, safflower, radix pseudostellariae, crow
During beans, fructus corni, Cortex Phellodendri, leech, Radix Ophiopogonis, stone reed, Sculellaria barbata, Radix Astragali, dry toad, Rhizoma Atractylodis Macrocephalae, RADIX MORINDAE OFFICINALIS, Herba Lespedezae Cuneatae and Radix Glycyrrhizae meet
Pertinent regulations under each medicinal material item of one text of state's pharmacopeia.Before feeding intake, by identification, ingredients material object is consistent with title, matter
Amount complies with standard.
The present invention provide it is a kind of for treating the Chinese medicine composition of nephrosis, raw material components by weight, including：Radix Notoginseng 20
~30 parts by weight, 10~25 parts by weight of rhizoma alismatis, 20~30 parts by weight of radix rehmanniae preparata, 15~20 parts by weight of Radix Codonopsis, 20~30 weight of earthworm
Part, 10~20 parts by weight of umbellate pore furgus, 20~30 parts by weight of Chinese yam, 10~20 parts by weight of safflower, 20~30 parts by weight of radix pseudostellariae, Wu Dou
10~15 parts by weight, 20~30 parts by weight of fructus corni, 25~35 parts by weight of Cortex Phellodendri, 10~25 parts by weight of leech, 15~25 weight of Radix Ophiopogonis
Measure part, 25~35 parts by weight of 15~25 parts by weight of stone reed and Sculellaria barbata.
Preferably, raw material components further include：20~30 parts by weight of Radix Astragali, 10~30 parts by weight of dry toad, 20~30 weight of Rhizoma Atractylodis Macrocephalae
Measure part, 20~30 parts by weight of 15~25 parts by weight of RADIX MORINDAE OFFICINALIS, 20~30 parts by weight of Herba Lespedezae Cuneatae and Radix Glycyrrhizae.
In addition, the present invention also provides the preparation method of above-mentioned Chinese medicine composition, include the following steps：
It is mixed after earthworm, radix pseudostellariae, Cortex Phellodendri and leech are crushed, water is then added, 45~50 DEG C are impregnated 120~150h,
Mixture after being impregnated；Wherein, the addition of water is 25~30 times of all raw material components gross masses；
Other surplus stock components are crushed, mixture after impregnating, then 160~180min of refluxing extraction is then added；
It is filtered after extraction, collects filtrate；Filtrate is concentrated, obtain at 25 DEG C measure when relative density be 1.05~
1.10 Chinese medicine composition.
Chinese medicine composition provided by the invention and preparation method thereof is described further with reference to specific embodiment.
Embodiment one
The present embodiment provides a kind of for treating the Chinese medicine composition of nephrosis, raw material components by weight, including：Radix Notoginseng
25 parts by weight, 17 parts by weight of rhizoma alismatis, 23 parts by weight of radix rehmanniae preparata, 17 parts by weight of Radix Codonopsis, 24 parts by weight of earthworm, 16 parts by weight of umbellate pore furgus, mountain
23 parts by weight of medicine, 16 parts by weight of safflower, 27 parts by weight of radix pseudostellariae, 11 parts by weight of black beans, 22 parts by weight of fructus corni, 30 weight of Cortex Phellodendri
Part, 19 parts by weight of leech, 31 parts by weight of 21 parts by weight of Radix Ophiopogonis, 17 parts by weight of stone reed and Sculellaria barbata.
Chinese medicine composition is prepared using preparation method provided by the invention by above-mentioned raw material：
It is mixed after leech, centipede and Radix Codonopsis are crushed, water, 48 DEG C of immersion 135h, mixture after being impregnated then is added；
Wherein, the addition of water is 27 times of all raw material components gross masses；
Other surplus stock components are crushed, mixture after impregnating then is added, then decoct extraction 170min；
It is filtered after extraction, collects filtrate；Filtrate is concentrated, during relative density is 1.10 when obtaining measuring at 25 DEG C
Drug composition.
Embodiment two
The present embodiment provides a kind of for treating the Chinese medicine composition of nephrosis, raw material components by weight, including：Radix Notoginseng
25 parts by weight, 17 parts by weight of rhizoma alismatis, 23 parts by weight of radix rehmanniae preparata, 17 parts by weight of Radix Codonopsis, 24 parts by weight of earthworm, 16 parts by weight of umbellate pore furgus, mountain
23 parts by weight of medicine, 16 parts by weight of safflower, 27 parts by weight of radix pseudostellariae, 11 parts by weight of black beans, 22 parts by weight of fructus corni, 30 weight of Cortex Phellodendri
Part, 19 parts by weight of leech, 21 parts by weight of Radix Ophiopogonis, 17 parts by weight of stone reed, 31 parts by weight of Sculellaria barbata, 26 parts by weight of Radix Astragali, dry toad 20
Parts by weight, 24 parts by weight of Rhizoma Atractylodis Macrocephalae, 27 parts by weight of 19 parts by weight of RADIX MORINDAE OFFICINALIS, 24 parts by weight of Herba Lespedezae Cuneatae and Radix Glycyrrhizae.
Chinese medicine composition is prepared using preparation method provided by the invention by above-mentioned raw material：
It is mixed after leech, centipede and Radix Codonopsis are crushed, water, 48 DEG C of immersion 135h, mixture after being impregnated then is added；
Wherein, the addition of water is 27 times of all raw material components gross masses；
Other surplus stock components are crushed, mixture after impregnating then is added, then decoct extraction 170min；
It is filtered after extraction, collects filtrate；Filtrate is concentrated, during relative density is 1.10 when obtaining measuring at 25 DEG C
Drug composition.
Embodiment three
The present embodiment provides a kind of for treating the Chinese medicine composition of nephrosis, raw material components by weight, including：Radix Notoginseng
20 parts by weight, 25 parts by weight of rhizoma alismatis, 20 parts by weight of radix rehmanniae preparata, 20 parts by weight of Radix Codonopsis, 20 parts by weight of earthworm, 20 parts by weight of umbellate pore furgus, mountain
20 parts by weight of medicine, 20 parts by weight of safflower, 20 parts by weight of radix pseudostellariae, 15 parts by weight of black beans, 20 parts by weight of fructus corni, 35 weight of Cortex Phellodendri
Part, 10 parts by weight of leech, 25 parts by weight of Radix Ophiopogonis, 15 parts by weight of stone reed, 35 parts by weight of Sculellaria barbata, 20 parts by weight of Radix Astragali, dry toad 30
Parts by weight, 20 parts by weight of Rhizoma Atractylodis Macrocephalae, 30 parts by weight of 25 parts by weight of RADIX MORINDAE OFFICINALIS, 20 parts by weight of Herba Lespedezae Cuneatae and Radix Glycyrrhizae.
Chinese medicine composition is prepared using preparation method provided by the invention by above-mentioned raw material：
It is mixed after earthworm, radix pseudostellariae, Cortex Phellodendri and leech are crushed, water, 45 DEG C of immersion 120h, after obtaining immersion is then added
Mixture；Wherein, the addition of water is 25 times of all raw material components gross masses；
Other surplus stock components are crushed, mixture after impregnating, then refluxing extraction 160min is then added；
It is filtered after extraction, collects filtrate；Filtrate is concentrated, during relative density is 1.05 when obtaining measuring at 25 DEG C
Drug composition.
Example IV
The present embodiment provides a kind of for treating the Chinese medicine composition of nephrosis, raw material components by weight, including：Radix Notoginseng
30 parts by weight, 10 parts by weight of rhizoma alismatis, 30 parts by weight of radix rehmanniae preparata, 15 parts by weight of Radix Codonopsis, 30 parts by weight of earthworm, 10 parts by weight of umbellate pore furgus, mountain
30 parts by weight of medicine, 10 parts by weight of safflower, 30 parts by weight of radix pseudostellariae, 10 parts by weight of black beans, 30 parts by weight of fructus corni, 25 weight of Cortex Phellodendri
Part, 25 parts by weight of leech, 15 parts by weight of Radix Ophiopogonis, 25 parts by weight of stone reed, 25 parts by weight of Sculellaria barbata, 30 parts by weight of Radix Astragali, dry toad 10
Parts by weight, 30 parts by weight of Rhizoma Atractylodis Macrocephalae, 20 parts by weight of 15 parts by weight of RADIX MORINDAE OFFICINALIS, 30 parts by weight of Herba Lespedezae Cuneatae and Radix Glycyrrhizae.
Chinese medicine composition is prepared using preparation method provided by the invention by above-mentioned raw material：
It is mixed after earthworm, radix pseudostellariae, Cortex Phellodendri and leech are crushed, water, 50 DEG C of immersion 150h, after obtaining immersion is then added
Mixture；Wherein, the addition of water is 30 times of all raw material components gross masses；
Other surplus stock components are crushed, mixture after impregnating, then refluxing extraction 180min is then added；
It is filtered after extraction, collects filtrate；Filtrate is concentrated, during relative density is 1.10 when obtaining measuring at 25 DEG C
Drug composition.
The Chinese medicine composition that the embodiment of the present invention one to example IV is prepared, its work(of progress clinical laboratory evaluations
Effect.
1, the effect of diabetic nephropathy is treated
It is diagnosed as the patient totally 160 of diabetic nephropathy, the age is to be randomly divided into 4 groups, every group 40 between 45~65 years old
Example.4 groups in gender, age and state of an illness etc., (the P that is statistically analyzed that there was no significant difference>0.05) it, is comparable.
Therapy：Everyone has the Chinese medicine group for treating nephrosis each taking corresponding group (every group of correspondence one embodiment)
Object 15g is closed, it is sooner or later each daily directly oral primary, it takes 20 days.
Curative effect determinate standard：It is effective：Clinical symptoms improve apparent, soreness and weakness of waist and knees, fatigue and weak, dry mouth and throat, enuresis nocturna frequency
The disappear or mostly disappears such as more, blood glucose level fluctuate in normal range (NR), blood pressure≤128/80mmHg, for 24 hours Urine proteins<30mg,
Blood urea nitrogen and creatinine are down to normal level；
Effectively：Clinical symptom relief, soreness and weakness of waist and knees, fatigue and weak, dry mouth and throat, night pollakiuria etc. be improved significantly,
Fasting blood-glucose control is ideal, and fluctuation of blood pressure has decline in 140/90mmHg or so, for 24 hours Urine proteins and blood urea nitrogen creatinine, but
It does not improve completely；
In vain：Clinical symptoms improve unobvious, and blood pressure and blood glucose are without declining or having decline but undesirable, and Urine proteins are fixed for 24 hours
Amount and blood urea nitrogen creatinine do not decline, or decline and be not up to effective standard.
As a result：Statistical procedures carry out data processing using SPSS statistical softwares, and clinical efficacy result is specifically shown in Table 1 institute
Show.
The different group patient clinical curative effects of table 1 compare
| Group | Effective (example) | Effectively (example) | (example) in vain | Total effective rate |
| Embodiment one | 16 | 20 | 4 | 90.0% |
| Embodiment two | 35 | 5 | 0 | 100% |
| Embodiment three | 33 | 7 | 0 | 100% |
| Example IV | 32 | 7 | 1 | 97.5% |
In addition, continue follow-up 3 years to above-mentioned patient, the patient after recovery from illness is without recurrence, and caused by there is not it
Side effect illustrates that Chinese medicine composition provided by the invention is without side-effects, can take safely.
2, model case
(1) Zhang, man 48 years old, are examined as diabetic nephropathy, spiritlessness and weakness, soreness and weakness of waist and knees, dim complexion in March, 2013,
Dizziness and tinnitus；Check Urine proteins (++), glucose in urine (++), fasting blood-glucose 12.3mmol/L.After begin to use the embodiment of the present invention two
The Chinese medicine composition being prepared, each taking 15g, sooner or later each daily oral primary, after taking 5 days, conditions of patients starts to subtract
Gently, hypourocrinia, spirit improve, and fatiguability symptom has improvement；To adhere to taking to 25 days, symptom all disappears, Urine proteins (-),
Glucose in urine (-), fasting blood-glucose 6.8mmol/L.Not there is recurrence in continuous follow-up 5 years afterwards, also without there is any secondary work
With.
(2) Chen, female, 56 years old, in May, 2014 was diagnosed as Type II diabetic nephropathy；It has type II diabetes medical history 8
Year, there is double lower limb oedema, Urine proteins (+) in two years ago patient, and serum creatinine increases, and rear double lower limb oedema aggravates, dim complexion, week
Body is weak, occasionally there is nausea, sleeps and feels unwell, and tongue is dark, tongue is greasy in vain, deep thready pulse；Urine proteins 5.6g/24h, 196 μm of ol/L of serum creatinine, urea
Nitrogen 16mmol/L.The Chinese medicine composition for beginning to use the embodiment of the present invention two to be prepared afterwards, each taking 15g, sooner or later daily
Each oral primary, after taking 7 days, conditions of patients starts to mitigate, and adheres to taking to 30 days, and symptom disappears substantially, serum creatinine and urine
Cellulose content returns to normal.Not there is recurrence in continuous follow-up 2 years afterwards, also without there is any side effect.
It should be noted that unless otherwise indicated, technical term or scientific terminology used in this application should be this hair
The ordinary meaning that bright one of ordinary skill in the art are understood.Unless specifically stated otherwise, it otherwise illustrates in these embodiments
Component and opposite step, numerical expression and the numerical value of step are not limit the scope of the invention.It is illustrated and described herein
In all examples, unless otherwise prescribed, any occurrence should be construed as merely illustrative, not as limitation, because
This, other examples of exemplary embodiment can have different values.
In the description of the present invention, it is to be understood that, term " first ", " second " are used for description purposes only, and cannot
It is interpreted as indicating or implies relative importance or implicitly indicate the quantity of indicated technical characteristic.Define as a result, " the
One ", the feature of " second " can explicitly or implicitly include one or more this feature.In the description of the present invention,
The meaning of " plurality " is two or more, unless otherwise specifically defined.
Finally it should be noted that：The above embodiments are only used to illustrate the technical solution of the present invention., rather than its limitations；To the greatest extent
Present invention has been described in detail with reference to the aforementioned embodiments for pipe, it will be understood by those of ordinary skill in the art that：Its according to
So can with technical scheme described in the above embodiments is modified, either to which part or all technical features into
Row equivalent replacement；And these modifications or replacements, various embodiments of the present invention technology that it does not separate the essence of the corresponding technical solution
The range of scheme should all cover in protection scope of the present invention.
Claims (9)
1. a kind of for treating the Chinese medicine composition of nephrosis, which is characterized in that raw material components by weight, including：
20~30 parts by weight of Radix Notoginseng, 10~25 parts by weight of rhizoma alismatis, 20~30 parts by weight of radix rehmanniae preparata, 15~20 parts by weight of Radix Codonopsis, earthworm
20~30 parts by weight, 10~20 parts by weight of umbellate pore furgus, 20~30 parts by weight of Chinese yam, 10~20 parts by weight of safflower, radix pseudostellariae 20~30
Parts by weight, 10~15 parts by weight of black beans, 20~30 parts by weight of fructus corni, 25~35 parts by weight of Cortex Phellodendri, 10~25 parts by weight of leech, wheat
25~35 parts by weight of 15~25 parts by weight of winter, 15~25 parts by weight of stone reed and Sculellaria barbata.
2. according to claim 1 for treating the Chinese medicine composition of nephrosis, which is characterized in that raw material components further include：
20~30 parts by weight of Radix Astragali, 10~30 parts by weight of dry toad, 20~30 parts by weight of Rhizoma Atractylodis Macrocephalae, 15~25 parts by weight of RADIX MORINDAE OFFICINALIS, snake
Fall back 20~30 parts by weight and 20~30 parts by weight of Radix Glycyrrhizae.
3. the Chinese medicine composition according to claim 2 for treating nephrosis, which is characterized in that raw material components are by weight
Meter, including：
25 parts by weight of Radix Notoginseng, 17 parts by weight of rhizoma alismatis, 23 parts by weight of radix rehmanniae preparata, 17 parts by weight of Radix Codonopsis, 24 parts by weight of earthworm, 16 weight of umbellate pore furgus
Measure part, 23 parts by weight of Chinese yam, 16 parts by weight of safflower, 27 parts by weight of radix pseudostellariae, 11 parts by weight of black beans, 22 parts by weight of fructus corni, Cortex Phellodendri
30 parts by weight, 19 parts by weight of leech, 21 parts by weight of Radix Ophiopogonis, 17 parts by weight of stone reed, 31 parts by weight of Sculellaria barbata, 26 parts by weight of Radix Astragali,
20 parts by weight of dry toad, 24 parts by weight of Rhizoma Atractylodis Macrocephalae, 27 parts by weight of 19 parts by weight of RADIX MORINDAE OFFICINALIS, 24 parts by weight of Herba Lespedezae Cuneatae and Radix Glycyrrhizae.
4. the preparation method of claim 1-3 any one of them Chinese medicine compositions, which is characterized in that including step：
It is mixed after earthworm, radix pseudostellariae, Cortex Phellodendri and leech are crushed, is then placed in water and impregnates, mixture after being impregnated；
Other surplus stock components are crushed, mixture after the immersion are then added, then extract；
It is filtered after extraction, collects filtrate；The filtrate is concentrated, the Chinese medicine composition is obtained.
5. the preparation method of Chinese medicine composition according to claim 4, it is characterised in that：
Described to be extracted as refluxing extraction, the time of the refluxing extraction is 160~180min.
6. the preparation method of Chinese medicine composition according to claim 4, it is characterised in that：
The temperature of the immersion is 45~50 DEG C, and the time of the immersion is 120~150h.
7. the preparation method of Chinese medicine composition according to claim 4, it is characterised in that：
The addition of the water is 25~30 times of all raw material components gross masses.
8. the preparation method of Chinese medicine composition according to claim 4, it is characterised in that：
Relative density is 1.05~1.10 when the Chinese medicine composition is measured at 25 DEG C.
9. claim 1-3 any one of them Chinese medicine composition is in the drug and/or medicated premix for preparing treatment nephrosis
Application.
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