CN108320782A - The kit of mental symptom degree of risk occurs for a kind of auxiliary judgment crystal methamphetamine user - Google Patents
The kit of mental symptom degree of risk occurs for a kind of auxiliary judgment crystal methamphetamine user Download PDFInfo
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- CN108320782A CN108320782A CN201810102717.5A CN201810102717A CN108320782A CN 108320782 A CN108320782 A CN 108320782A CN 201810102717 A CN201810102717 A CN 201810102717A CN 108320782 A CN108320782 A CN 108320782A
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- G06Q—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES; SYSTEMS OR METHODS SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES, NOT OTHERWISE PROVIDED FOR
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Abstract
The invention discloses the kits that mental symptom degree of risk occurs for a kind of auxiliary judgment crystal methamphetamine user.It includes parameter acquisition scale and readable carrier；Parameter acquisition scale includes the scale of the parameters involved in the readable carrier of acquisition；The content such as following formula I, y=0.149x are described on readable carrierseverity+0.018xCTQ+0.079xADHD‑0.034xSSSFormula I；xseverityIndicate crystal methamphetamine habituation severity score value；xCTQIndicate that children trauma undergoes total score；xADHDADHD symptom total scores during expression primary school；xSSSIndicate the social support degree total score of subject；Y indicates that the risk of mental symptom occurs for subject；Subject age is 18~60 years old.Y values are calculated in kit through the invention when being 0, indicate that spirit is normal, when y values are calculated by 0 to 1, y values are bigger indicate subject occur mental symptom risk it is bigger.The present invention is easily mastered use；Scientific basis can be provided for the relationship of drug habit and mental disease, and early warning is provided for drug habit patient.
Description
Technical field
The present invention relates to the kits that mental symptom degree of risk occurs for a kind of auxiliary judgment crystal methamphetamine user, belong to
In biologic medical field.
Background technology
Substance addiction is a kind of chronic recurrent encephalopathy, is mainly characterized by mandatory drug use, duration craving state
With the decrease to drug craving control force.Especially the synthetic drugs such as ice (crystal methamphetamine) abuse is presented quick in recent years
Growth trend.There is the psychoactive drug substances such as crystal methamphetamine very strong psychoneural toxic effect, long-time service can cause line
The damage of the aixs cylinder of dopaminergic neuron and nerve endings even nerve fibre denaturation and brain neopallium, sea in shape body
The damage of horse etc. additionally can generate toxicity to histoorgans such as heart, liver, lung, kidney and skeletal muscle.
The more traditional drugs of crystal methamphetamine are compared to various phrenoblabias are more prone to, as psychotic disorders, mood hinder
Hinder, personality disorder etc., mental symptom, which occurs, for addict can lead to the serious social danger such as violence, suicide, compared with being not accompanied by spirit
Addict's social danger of symptom is even more serious.The insanity performance of crystal methamphetamine user and extent of damage difference are very
Greatly, it is significantly affected by h and E.
Before research think, crystal methamphetamine user occur mental symptom mainly by crystal methamphetamine using itself and its
He causes social adverse events.Crystal methamphetamine user's drugs dosage and frequency are higher, and mental symptom occurs for future
Possibility is bigger.Also studies have found that mental symptom whether occurs also uses age, crystal methamphetamine with crystal methamphetamine for the first time
The factors such as usage time are related.In addition, being sent out after crystal methamphetamine user social adverse events and crystal methamphetamine use throughout one's life
Production of sperm god's symptom relationship is close.Addictive Behaviors normally starts from teenager or adult early stage, especially has high risk to suffer from spirit
The individual of disease is easier habituation, and the dangerous higher of mental disease occurs for addict with mental disease risk itself.It grinds
Study carefully and shows the adverse events such as boyhood physical abuse, mental cruelty, parental separation not only and can increase individual adult abuse methylbenzene
The risk of propylamine, and be more prone to mental symptom, and addict whether occur insanity by habituation severity and
The influence of children trauma comprehensive function.In addition, childhood behavioral problem, especially attention deficit hyperactivity disorder (attention
Deficit hyperactivity disorder, ADHD) may be manhood habituation high risk factor.The past studies have shown that
There are have quite high ratio comorbidity ADHD in the teenager of Addictive Behaviors.The personality makings of ADHD and addictive disorders has very big heavy
It is folded, including self-management it is difficult, cannot keep quite, " behavior is out of control " (such as impulsion cannot be adhered to).One system of Addictive Behaviors
List is existing highly relevant with ADHD symptoms, such as behavior (behavioral under control) out of control or behavior disinhibition
(behavioral disinhibition) etc., childhood the above-mentioned performance that occurs be likely to predict the following substance abuse
Occur.Therefore, very dangerous behavior performance and symptom are monitored in the children and youth stage, to the early prevention meaning weight of Addictive Behaviors
Greatly, the generation that mental symptom after habituation is avoided from source that can also be earlier；Meanwhile children trauma and ADHD are at this stage
It can treat in time, these individuals of early intervention can not only reduce the risk of the substance abuses such as crystal methamphetamine, also can
The harm of insanity and other complication caused by reducing habituation as far as possible, equally has certain therapeutic potential.
In conclusion the mental symptom state of an illness that addict occurs is various, childhood Trauma and suffer from caused by child psychosis
Adult after to suffer from Addictive Behaviors mechanism altogether complicated, be related to heredity, nervous physiology and psychological development, formation of personality and deviation and
The reciprocation of social environmental factor, not yet illustrates completely so far, does not also have systematic method to carry out EARLY RECOGNITION in real work
The population at risk of mental symptom occurs for crystal methamphetamine user's future.
Invention content
The object of the present invention is to provide mental symptom degree of risk occurs after a kind of auxiliary judgment crystal methamphetamine use
Kit, the present invention are easily mastered use；Can be that the relationship of drug habit and mental disease provide scientific basis, and be drug at
Addiction patient provides early warning.
The kit of mental symptom degree of risk occurs for a kind of auxiliary judgment crystal methamphetamine user provided by the invention,
It includes parameter acquisition scale and readable carrier；
The parameter acquisition scale includes the scale of the parameters involved in the acquisition readable carrier；
The content such as following formula I is described on the readability carrier,
Y=0.149xseverity+0.018xCTQ+0.079xADHD-0.034xSSSFormula I；
xseverityIndicate crystal methamphetamine habituation severity score value；
xCTQIndicate that children trauma undergoes total score；
xADHDADHD symptom total scores during expression primary school；
xSSSIndicate the social support degree total score of subject；
Y indicates that the risk of mental symptom occurs for subject；
The subject age is 18~60 years old.
In above-mentioned kit, the parameter acquisition assessment scale includes crystal methamphetamine habituation clinical severity scale, child
Term wound undergoes scale, attention deficit-hyperactivity disorder Research advancement on measuring scale and social support degree scale；
The kit further includes equipments of recording and/or calculating instrument；The equipments of recording include pen and/or computer；
The calculating instrument includes calculator and/or the computer.
In above-mentioned kit, the readability carrier is kit specification；The print matter of the formula I is in card
On.
In above-mentioned kit, the readability carrier is computer readable carrier.
The present invention also provides the suits that mental symptom occurs for a kind of auxiliary judgment crystal methamphetamine user comprising first
Base amphetamine addiction clinical severity scale, children trauma experience scale, attention deficit-hyperactivity disorder Research advancement on measuring scale, social support
Degree scale and the computing device for being provided with parameter computing module；The parameter computing module can carry out the operation such as following formula I：
Y=0.149xseverity+0.018xCTQ+0.079xADHD-0.034xSSSFormula I；
xseverityIndicate crystal methamphetamine habituation severity score value；
xCTQIndicate that children trauma undergoes total score；
xADHDADHD symptom total scores during expression primary school；
xSSSIndicate the social support degree total score of subject；
Y indicates that the risk of mental symptom occurs for subject.
The present invention also provides the uses that the kit of mental symptom occurs for the auxiliary judgment crystal methamphetamine user
Method includes the following steps：
1) during crystal methamphetamine habituation severity score value, children trauma the experience total score of measurement subject, primary school
The social support degree total score of ADHD symptoms total score and subject, and recorded；
2) operation is carried out according to such as following formula I：
Y=0.149xseverity+0.018xCTQ+0.079xADHD-0.034xSSSFormula I；
xseverityIndicate crystal methamphetamine habituation severity score value；
xCTQIndicate that children trauma undergoes total score；
xADHDADHD symptom total scores during expression primary school；
xSSSIndicate the social support degree total score of subject；
Y indicates that the risk of mental symptom occurs for subject.
The present invention also provides parameter acquisition scales and readable carrier to prepare auxiliary judgment crystal methamphetamine user
The application in the kit of mental symptom occurs, wherein the parameter acquisition scale includes acquiring to relate in the readable carrier
And parameters scale；
The content such as following formula I is described on the readability carrier,
Y=0.149xseverity+0.018xCTQ+0.079xADHD-0.034xSSSFormula I；
xseverityIndicate crystal methamphetamine habituation severity score value；
xCTQIndicate that children trauma undergoes total score；
xADHDADHD symptom total scores during expression primary school；
xSSSIndicate the social support degree total score of subject；
Y indicates that the risk of mental symptom occurs for subject.
In above-mentioned application, the parameter acquisition assessment scale includes crystal methamphetamine habituation clinical severity scale, childhood
Phase wound undergoes scale, attention deficit-hyperactivity disorder Research advancement on measuring scale and social support degree scale.
In above-mentioned application, the readability carrier is kit specification；The print matter of the formula I is on card.
Invention further provides crystal methamphetamine habituation clinical severity scale, children trauma experience scale, pay attention to
It power defect hyperactivity Research advancement on measuring scale, social support degree scale and is provided with the computing device of parameter computing module and assists preparing
Judge that the application in the suit of mental symptom occurs for crystal methamphetamine user, wherein the parameter computing module of being provided with
Computing device can carry out the operation such as following formula I：
Y=0.149xseverity+0.018xCTQ+0.079xADHD-0.034xSSSFormula I；
xseverityIndicate crystal methamphetamine habituation severity score value；
xCTQIndicate that children trauma undergoes total score；
xADHDADHD symptom total scores during expression primary school；
xSSSIndicate the social support degree total score of subject；
Y indicates that the risk of mental symptom occurs for subject.
The present invention uses psychological cognition and other behaviouristics methods, its habituation is investigated being grown up in crystal methamphetamine user
A situation arises and other critical events for feature, psychiatric symptoms, and its childhood Trauma of Retrospective review experience and mental disease
Sample symptom analyzes habituation and the relevant risk factors of psychiatric symptoms.And a set of Research advancement on measuring scale is integrated based on result, establish first
The regression model of mental symptom occurs for base amphetamine user, using tool prediction subject using after crystal methamphetamine whether
The new application of mental symptom occurs.
The present invention has the following advantages：
The present invention is for professional spirit disease doctor, community volunteer, crystal methamphetamine user family members even methylbenzene third
Amine user grasps and uses；Scientific basis can be provided for the relationship of drug habit and mental disease, and be exploitation habituation
The early warning strategy of patient provides academic support.
Description of the drawings
Fig. 1 is that mental symptom risk factors regression analysis occurs for crystal methamphetamine user.
Fig. 2 is to predict whether crystal methamphetamine user occurs the prediction model efficiency point of mental symptom using risk factors
Analysis.
Fig. 3 is that crystal methamphetamine uses obstacle severity Diagnostic Scale.
The course of growth scale of childhood that Fig. 4 is (before 16 years old) (i.e. children trauma undergoes scale).
Fig. 5 is attention deficit-hyperactivity disorder Research advancement on measuring scale.
Fig. 6 is social support degree scale.
Specific implementation mode
Experimental method used in following embodiments is conventional method unless otherwise specified.
The materials, reagents and the like used in the following examples is commercially available unless otherwise specified.
This experiment acquires essential information interview, habituation feature and scale evaluation, assessment subject's essence by subjects recruitment
Associated Variable Factors occur for refreshing disease sample symptom and experience of life, clear and crystal methamphetamine habituation mental symptom.
1, subject recruitment (1838 crystal methamphetamine users)
(1) process is recruited：
1) information publication is recruited：Recruitment information is issued from project team member to suitable crystal methamphetamine user (to pass through
It is underground to recruit information for the forms such as phone, SMS or wechat), information can will be recruited when necessary posts up community's drug rehabilitation work
It stands etc. and to be confined to the place of habituation personnel activity.
2) informed consent process：To ensure that subject is not influenced by known social worker or people's police, voluntary participation research,
Informed consent is studied to carry out whole process by project team member and the one-to-one interview of subject.
3) subject's secret protection：Since this experiment is related to personal tender subject, questionnaire is carried out using anonymous way.
The personal information page of case report form replaces name with coding, additionally sets up the archives of the content of a name and coding, separates
Keeping.Information is recruited to be not released publicly.It is only that scientific research uses, and promises to undertake that this data, which is described in detail, to subject before investigation
Subject information is maintained secrecy, and illustrates the risk that possible privacy is divulged a secret.
(2) inclusion criteria：
1) Han nationality；
2) age is more than 18 years old and is less than 60 years old；
3) diagnostic criteria that p-Methylamphetamine in DSM-V uses obstacle need to be met, there is urine examination positive record；
4) Clear consciousness, cognitive ability is normal, and mandarin is linked up and write accessible；
5) informed consent form, this project of voluntary participation be endorsed.
(3) exclusion criteria：
1) alcohol addiction (person screens scale screening with concise alcohol dependence first if there is alcohol drinking patterns), non-excitant class habituation
(use addictive drug in addition to crystal methamphetamine, head-shaking pill, cocaine, ephedrine, caffeine is used continuously in nearly 1 year
More than 1 month, use 3 times or more weekly) and smoking capacity is more than 40 persons daily；
2) compliance is poor：Except researcher think can not compatibility test subject.
(4) standard is rejected：It finds to lie about data in the course of the research or conceals its people truth person.
2, essential information acquisition and habituation collection apparatus
Essential information include the age, gender, subject source, the length of education enjoyed, mental disease Genetic history, situation of drinking and
Tobacco smoking status.Crystal methamphetamine use information includes whether that multiple drug abuse, crystal methamphetamine occupation mode, first suction is felt, head inhales
It age, frequency of use, dosage, crystal methamphetamine usage time, last crystal methamphetamine dosage and gives up the time；
Habituation severity uses in mental disease diagnostic ＆ statistical manual the 5th edition (DSM-V) about crystal methamphetamine habituation degree
Diagnostic criteria.
3, psychiatric symptoms and sociology variable evaluative
By self-appraisal questionnaire survey (including mental symptom inventory (Symptom checklist 90, SCL-90), childhood
Phase wound undergoes scale (Childhood trauma questionnaire, CTQ), attention deficit-hyperactivity disorder Research advancement on measuring scale
(ADHD ratingscale- IV, ADHD) and social support degree scale (SocialSupportRatingScale, SSS)) it surveys
Measure the recent mental symptom of subject (SCL-90screening), children trauma undergoes ADHD symptoms during (CTQ), primary school
(ADHD), the social support degree (SSS) of subject.The particular content of 4 Research advancement on measuring scale, as seen in figures 3-6.Fig. 3 is methyl
Amphetamine uses obstacle severity Diagnostic Scale, and whether totally 11 topic, have situation described in table according to crystal methamphetamine user
Scoring, each case count 1 point if meeting, seek total score.Course of growth scale (the i.e. childhood of childhood that Fig. 4 is (before 16 years old)
Phase wound undergoes scale), it totally 28 inscribes, according to course of growth childhood crystal methamphetamine user (before 16 years old) from " always
There is no this phenomenon (1 point), once in a while (2 points), sometimes (3 points), often (4 points), always (5 points) " select in five options it is most suitable
The answer of conjunction, seeks total score.Fig. 5 is attention deficit-hyperactivity disorder Research advancement on measuring scale, totally 18 topic, and crystal methamphetamine user is according to primary school
The performance of period belongs to any situation (without=1 point, once in a while=2 point, usually=3 point, always=4 point) score, seeks total score.Fig. 6
For social support degree scale, totally 10 topic, the specific requirement of each problem score is：~7 topic of 1 topic, 10 topic option serial numbers are
Score (1 point~4 points)；8 topics, 9 topics：Without any source=0 point, there is source person's option number i.e. goals for, seek total score.
4, statistical analysis
The statistical analysis of data is carried out using 22.0 softwares of SPSS.It counts crystal methamphetamine user's drugs and uses spy
Sign, each social mentality's events incidence and degree, filter out the crystal methamphetamine patient for the sample symptom that is mentally ill.It utilizes
The drugs of two groups of crowds of Logistic analysis of regression model inquire into crystal methamphetamine using feature and the difference of social mentality's event
There are the risk factors of mental symptom in user, according to the AUC curve assessments prediction model efficiency.Prediction model cycle 10000
It is secondary with ensure result stablize.
As shown in table 1, basic condition, crystal methamphetamine usage behavior feature and the sociology scale score 1838 being tested
Do not do correlation analysis with recent mental symptom, by table 1 the result shows that with whether the significantly correlated variable of mental symptom occurring
Including clinical center, gender, whether multiple drug abuse, each crystal methamphetamine dosage, crystal methamphetamine just inhale age, methyl
The correlation of ADHD performances and social support situation during amphetamine usage time, children trauma, primary school.
1 crystal methamphetamine user's mental symptom correlation analysis of table
Note：* correlations notable (bilateral) on 0.01；* correlation notable (bilateral) on 0.05.
Logistics regression analyses are done using the above significantly correlated project as candidate independent variable, find crystal methamphetamine
Whether user occurs the risk factors of mental symptom, the results showed that is controlling clinical center (center), gender
(gender) and after situation of drinking (drinking) data, whether crystal methamphetamine user occurs mental symptom (SCL-
90screening) significant risk factor includes crystal methamphetamine habituation severity (severity), children trauma experience
(CTQ), ADHD shows (ADHD) and social support situation (SSS) during primary school, and the results are shown in Figure 1.By Fig. 1 the result shows that first
Whether base amphetamine user occurs mental symptom not only to crystal methamphetamine using itself is related, also with other above-mentioned sociologys
Variable is related.
Using crystal methamphetamine habituation severity score, ADHD symptoms are total during children trauma undergoes total score, primary school
Divide and the social support degree total score of subject can build whether prediction crystal methamphetamine user's future occurs mental symptom
Model.The crystal methamphetamine habituation severity of this 1838 subjects, children trauma experience, ADHD performances, society during primary school
Situation and recent mental symptom data can be supported to be randomly divided into 10 parts, take the training set of 9 parts of models that give a forecast at random, 1 part do it is pre-
The test set of model is surveyed to build prediction model, this process repeats 10000 times to ensure that result is stablized.
The logistic regression models of mental symptom occur for auxiliary judgment crystal methamphetamine user as shown in following formula I：
Y=0.149xseverity+0.018xCTQ+0.079xADHD-0.034xSSSFormula I；
xseverityIndicate crystal methamphetamine habituation severity score value；
xCTQIndicate that children trauma undergoes total score；
xADHDADHD symptom total scores during expression primary school；
xSSSIndicate the social support degree total score of subject；
Y indicates that the risk of mental symptom occurs for subject；
Subject age is 18~60 years old.
AUC is 0.74 (95%CI=0.713~0.764) after the mold cycle 10000 times, as shown in Fig. 2, being said by Fig. 2
The prediction efficiency of bright model of the present invention is preferable.
It therefore, being capable of auxiliary judgment crystal methamphetamine addict generation psychosis using the kit for recording above-mentioned model
The risk of shape indicates that spirit is normal when it is 0 that y values, which are calculated, when y values are calculated by 0 to 1, y values are bigger indicate by
The risk that mental symptom occurs in examination person is bigger.
Claims (10)
1. the kit of mental symptom degree of risk occurs after a kind of auxiliary judgment crystal methamphetamine use comprising parameter acquisition
Scale and readable carrier；
The parameter acquisition scale includes the scale of the parameters involved in the acquisition readable carrier；
The content such as following formula I is described on the readability carrier,
Y=0.149xseverity+0.018xCTQ+0.079xADHD-0.034xSSSFormula I；
xseverityIndicate crystal methamphetamine habituation severity score value；
xCTQIndicate that children trauma undergoes total score；
xADHDADHD symptom total scores during expression primary school；
xSSSIndicate the social support degree total score of subject；
Y indicates that the risk of mental symptom occurs for subject；
The subject age is 18~60 years old.
2. kit according to claim 1, it is characterised in that：The parameter acquisition assessment scale includes crystal methamphetamine
Habituation clinical severity scale, children trauma experience scale, attention deficit-hyperactivity disorder Research advancement on measuring scale and social support degree amount
Table；
The kit further includes equipments of recording and/or calculating instrument；The equipments of recording include pen and/or computer；It is described
Calculating instrument includes calculator and/or the computer.
3. kit according to claim 1 or 2, it is characterised in that：The readability carrier is kit specification；Institute
The print matter of formula I is stated on card.
4. kit according to claim 1 or 2, it is characterised in that：The readability carrier is computer readable carrier.
5. the suit of mental symptom occurs for a kind of auxiliary judgment crystal methamphetamine user comprising crystal methamphetamine habituation is serious
Degree scale, children trauma undergo scale, attention deficit-hyperactivity disorder Research advancement on measuring scale, social support degree scale and are provided with
The computing device of parameter computing module；The parameter computing module can carry out the operation such as following formula I：
Y=0.149xseverity+0.018xCTQ+0.079xADHD-0.034xSSSFormula I；
xseverityIndicate crystal methamphetamine habituation severity score value；
xCTQIndicate that children trauma undergoes total score；
xADHDADHD symptom total scores during expression primary school；
xSSSIndicate the social support degree total score of subject；
Y indicates that the risk of mental symptom occurs for subject.
6. the application method of the kit of mental symptom occurs for auxiliary judgment crystal methamphetamine user described in claim 1-4,
Include the following steps：
1) the crystal methamphetamine habituation severity score value of subject is measured, children trauma undergoes ADHD during total score, primary school
The social support degree total score of symptom total score and subject, and recorded；
2) operation is carried out according to such as following formula I：
Y=0.149xseverity+0.018xCTQ+0.079xADHD-0.034xSSSFormula I；
xseverityIndicate crystal methamphetamine habituation severity score value；
xCTQIndicate that children trauma undergoes total score；
xADHDADHD symptom total scores during expression primary school；
xSSSIndicate the social support degree total score of subject；
Y indicates that the risk of mental symptom occurs for subject.
7. parameter acquisition scale and readable carrier are in the examination for preparing auxiliary judgment crystal methamphetamine user generation mental symptom
Application in agent box, wherein the parameter acquisition scale includes the amount of the parameters involved in the acquisition readable carrier
Table；
The content such as following formula I is described on the readability carrier,
Y=0.149xseverity+0.018xCTQ+0.079xADHD-0.034xSSSFormula I；
xseverityIndicate crystal methamphetamine habituation severity score value；
xCTQIndicate that children trauma undergoes total score；
xADHDADHD symptom total scores during expression primary school；
xSSSIndicate the social support degree total score of subject；
Y indicates that the risk of mental symptom occurs for subject.
8. application according to claim 7, it is characterised in that：Parameter acquisition assessment scale include crystal methamphetamine at
Addiction clinical severity scale, children trauma experience scale, attention deficit-hyperactivity disorder Research advancement on measuring scale and social support degree scale.
9. application according to claim 7 or 8, it is characterised in that：The readability carrier is kit specification；It is described
The print matter of formula I is on card.
10. crystal methamphetamine habituation clinical severity scale, children trauma undergo scale, attention deficit-hyperactivity disorder test and appraisal amount
It table, social support degree scale and is provided with the computing device of parameter computing module and uses preparing auxiliary judgment crystal methamphetamine
Application in the suit of mental symptom occurs for person, wherein the computing device for being provided with parameter computing module can carry out such as
The operation of following formula I：
Y=0.149xseverity+0.018xCTQ+0.079xADHD-0.034xSSSFormula I；
xseverityIndicate crystal methamphetamine habituation severity score value；
xCTQIndicate that children trauma undergoes total score；
xADHDADHD symptom total scores during expression primary school；
xSSSIndicate the social support degree total score of subject；
Y indicates that the risk of mental symptom occurs for subject.
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