CN108313367A - A kind of vitamin C Yinqiao tablet of filling with inert gas packaging - Google Patents

A kind of vitamin C Yinqiao tablet of filling with inert gas packaging Download PDF

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Publication number
CN108313367A
CN108313367A CN201810163868.1A CN201810163868A CN108313367A CN 108313367 A CN108313367 A CN 108313367A CN 201810163868 A CN201810163868 A CN 201810163868A CN 108313367 A CN108313367 A CN 108313367A
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Prior art keywords
tablet
vitamin
parts
inert gas
filling
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CN201810163868.1A
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Chinese (zh)
Inventor
帅放文
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Hunan Er Kang Pharmaceutical Co Ltd
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Hunan Er Kang Pharmaceutical Co Ltd
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Priority to CN201810163868.1A priority Critical patent/CN108313367A/en
Publication of CN108313367A publication Critical patent/CN108313367A/en
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B31/00—Packaging articles or materials under special atmospheric or gaseous conditions; Adding propellants to aerosol containers
    • B65B31/02—Filling, closing, or filling and closing, containers or wrappers in chambers maintained under vacuum or superatmospheric pressure or containing a special atmosphere, e.g. of inert gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/346—Platycodon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/538—Schizonepeta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/634—Forsythia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone

Abstract

A kind of vitamin C Yinqiao tablet of filling with inert gas packaging, the tablet are protected by the wall material packaging and filling with inert gas of the oxygen that blocks water, can effectively prevent drug oxidation, moisture absorption, increase its stability, extend its shelf-life.

Description

A kind of vitamin C Yinqiao tablet of filling with inert gas packaging
Technical field
The invention belongs to field of medicaments, more particularly to a kind of vitamin C Yinqiao tablet of filling with inert gas packaging.
Background technology
Vitamin C Yinqiao tablet is widely used Chinese and Western medicine composite preparation, has the effect of expelling wind to resolve the exterior, clearing heat and detoxicating.It is clinical Influenza caused by upper common-use words treatment affection of exogenous wind-heat, symptoms include fever, have a headache, cough, dry is had sore throat.Due to matching Vitamin C in side is oxidized easily, and paracetamol can be oxidized to quinones substance, and peppermint oil dementholized is volatile, causes to protect Content does not reach requirement during matter, unstable quality.
At present usually there is a certain amount of air in the use ordinary packing of vitamin C Yinqiao tablet, product packaging inside, and the time is grown It easily contacts and reacts with the oxygen in air, the content decline of vitamin C, paracetamol destroys product quality and medicine Phenomena such as imitating, and contacted with air and also easily cause the moisture absorption, the microorganisms hyperplasia such as pathogenic bacteria, mould and anti-oil occurs, causes Tablet is rotten, can cause damages to user's health.2015 editions《Chinese Pharmacopoeia》Provide that every vitamin C Yinqiao tablet contains vitamin C is 49.5mg, paracetamol 105mg, chlorphenamine maleate 1.05mg.Therefore, suitable coating auxiliary material is selected, or logical It is very crucial to cross change packaging raising stability of drug products.
Traditional handicraft mostly uses greatly backward syrup coat technique, adds the auxiliary materials such as talcum powder, sucrose, gelatin that sugar coated tablet is made Agent, sugar coated tablet preparation procedure is complicated, and coating is thick, keeps drug weightening more, sliver easily occurs, piebald, mildew, disintegration time-out, has The shortcomings of effective component content declines, hygroscopicity is strong and not easy to maintain.And this research uses polyvinyl alcohol at film base material, addition is anti- Oxidant ubiquinone10, plasticizer glycerine, the coating film prepared, with antioxidation；Tablet package uses aluminium-plastics pressure The oxygen wall material that blocks water that layer body is constituted, bottom plate are formed by cold forming paillon, are covered with the gold for the metal foil that can be open by tablet thereon Belong to layer closing packaging, one tablet is packed into a blister when packaging, is taken out to blister using nozzle-type vacuum plant Vacuum is used in combination under the atmosphere of gas tube filling with inert gas and packs and seal.The blister of inert gas is filled, has isolation empty Gas prevents tablet oxidation, the moisture absorption, energy effective protection tablet composition from not destroyed by air oxidation, improves the stabilization of vitamin C Yinqiao tablet Property, extend its shelf-life.
Invention content
The present invention provides a kind of vitamin C Yinqiao tablet of filling with inert gas packaging.
The vitamin C Yinqiao tablet is prepared by the Chinese medicine and Western medicine of following weight proportion, 20-40 parts of Honeysuckle flower, Fructus Forsythiae 20-40 parts, 8-16 parts of schizonepeta, 10-20 parts of Fermented Soybean, 8-12 parts of lophatherum gracile, 12-24 parts of great burdock achene, 12-24 parts of reed root, campanulaceae 12-24 parts, 10-20 parts of Radix Glycyrrhizae, 0.117-0.234 parts of chlorphenamine maleate, 11.7-23.4 parts of paracetamol, dimension life Plain C5.5-11 parts and 0.12-0.24 parts of peppermint oil dementholized.
A kind of vitamin C Yinqiao tablet of described filling with inert gas packaging, the tablet blocks water oxygen packaging in loading, through evacuation Gas, after filling with inert gas is packed and sealed, the shelf-life of the tablet is at least 24 months.
The oxygen wall material that blocks water is packaged as blister package.
The blister package is that aluminium-plastics laminate layer body is constituted, and bottom plate is formed by cold forming paillon, and being covered with thereon can be by piece The metal layer closing packaging of the metal foil of agent opening.
The inert gas is one kind in nitrogen, helium, argon gas and carbon dioxide, preferably nitrogen.
The tablet includes disintegrant and diluent, and the disintegrant is croscarmellose sodium, and diluent is dry Starch.
The tablet includes adsorbent, and the adsorbent is light magnesium oxide.
The tablet film coating, the film-coating is by 8% polyvinyl alcohol（PVA）Solution, 1.0% ubiquinone10With 0.7% glycerine Composition.
The manufacturing method of the vitamin C Yinqiao tablet of the filling with inert gas packaging, the blister for the oxygen that each blocks water is interior to place One tablet vacuumizes blister using nozzle-type vacuum plant, is used in combination gas tube to fill under the atmosphere of indifferent gas and packs And it seals.
Usefulness of the present invention：
（1）For light magnesium oxide as tablet adsorbent, large specific surface area is very strong to oily adsorptivity, adsorbs 2 times of amount volatile oil and is still in Powdery is made mixture, is kept with the volatile oil and peppermint oil dementholized extracted in light magnesium oxide absorption Fructus Forsythiae, schizonepeta, Honeysuckle flower Good mobility is conducive to improve particle compressibility, solves the problems, such as tabletting sliver, raising label quality.
（2）Abandoning tradition syrup coat technique uses polyvinyl alcohol at film base material, to add antioxidant ubiquinone10, increase Agent glycerine is moulded, prepares the coating film with antioxidant activity, manufactured Vitaminc lonicera and forsythia Film coated tablets stability is more preferable.
（3）Packaging is using the oxygen wall material that blocks water, and using cold forming paillon as bottom plate, metal foil layer is that covering is constituted, tablet dress After entering blister, through taking out air, after filling with inert gas is packed and sealed, the shelf-life of the tablet is at least 24 months.
Specific implementation mode
Now with reference to following embodiments, the present invention will be further described.
The tablet is prepared as follows.
Take 20 parts of Fructus Forsythiae, 8 parts of schizonepeta, 20 parts of Honeysuckle flower, extraction by steam distillation volatile oil spare；The dregs of a decoction and henon bamboo 8 parts of leaf, 10 parts of Fermented Soybean, 12 parts of reed root, 12 parts of campanulaceae, 10 parts of Radix Glycyrrhizae add water to cook, and obtain extracting solution；12 parts of great burdock achene is taken, is set It in microwave radiation exaraction device, is extracted with 60% ethyl alcohol, filtering, filtrate recycling ethanol, paraffin, which is added, makes dissolving, and it is floating to be cooled to paraffin In liquid level, paraffin layer is removed；By volatile oil and 0.12 part of mixing of peppermint oil dementholized, with the adsorbent light magnesium oxide of 0.6 times of quality Adsorb into mixture of volatile oil；Merge above-mentioned liquid, concentrate, be dried to dried cream powder, mixture of volatile oil, appropriate diluent is added Dried starch collapses agent agent croscarmellose sodium and water, mixing, granulation；Add 11.7 parts of paracetamol, maleic acid chlorobenzene That quick 0.117 part and 5.5 parts of vitamin C, appropriate glidant superfine silica gel powder, mixing, tabletting are wrapped thin with antioxidant activity Film clothing, it is 0.25g/ piece vitamin C Yinqiao tablets to obtain specification.
Gained tablet is packaged in blister package：Contain one tablet in each blister, in nozzle-type vacuum plant Blister is vacuumized, is used in combination under the atmosphere of gas tube inflated with nitrogen and packs and seal, obtain vitamin C Yinqiao tablet product.
Comparative example 1
Vitamin C Yinqiao tablet is prepared by patent CN104189588A methods, and uses ordinary packing.
Comparative example 2
Vitamin C Yinqiao tablet is prepared by patent CN104888021A methods, and uses ordinary packing.
Test example 1
The assay of vitamin C, paracetamol and chlorphenamine maleate in vitamin C Yinqiao tablet
（1）The preparation of mixed reference substance solution：Precision weighs paracetamol, chlorphenamine maleate and vitamin C control Appropriate product add methanol that every 1mL is made mixed containing 0 μ g of 80 μ g of paracetamol, 40 μ g of chlorphenamine maleate and Catergen Close solution to get.
（2）Test solution：Vitamin C Yinqiao tablet of the embodiment of the present invention 5 is taken, coating is removed, it is accurately weighed, fine powder 01g is taken, It sets in 50mL measuring bottles, adds methanol dilution to scale, be ultrasonically treated 20min（Frequency 50KHz）, shake up, supplemented with methanol after letting cool To scale, supernatant is taken to cross miillpore filter, take subsequent filtrate to obtain the final product.
（3）Chromatographic condition：Chromatographic column is ypersil NH2(250nm×4.6mm, 5µm)；With -0.05% trifluoro of acetonitrile Acetic acid is mobile phase（70:30）, flow velocity 1.0mL/min, Detection wavelength 245nm, column temperature is 30 DEG C, 10 μ L of sample size.
（4）The drafting of standard curve：1.0,2.5,5.0,7.5,10.0,13.0 μ L of mixed reference substance solution are drawn respectively, It is analyzed according to above-mentioned chromatographic condition, with reference substance sample size (μ g) for abscissa, chromatographic peak peak area is ordinate, is drawn Standard curve.
（3）Assay：Test solution is taken, sample introduction is analyzed by above-mentioned chromatographic condition, measures chromatographic peak peak area, respectively Paracetamol, chlorphenamine maleate and ascorbic content are calculated by respective standard curve.
（4）Experimental result：It is 50.2mg, acetparaminosalol that result of calculation, which show that averagely every vitamin C Yinqiao tablet contains vitamin C, Phenol 106.4mg, chlorphenamine maleate 1.12mg, meets standards of pharmacopoeia.
Test example 2
Vitamin C Yinqiao tablet dissolution determination
The Vitaminc lonicera and forsythia for the known Determination Paracetamol in Paracetamol that respectively prepared by Example, comparative example 1, comparative example 2 Piece, using paracetamol as the dissolution rate of index determining vitamin C Yinqiao tablet.According to the existing quality in China of paracetamol tablets Standard, using Rotating shaker, rotating speed 100r/min, with dilute hydrochloric acid（Hydrochloric acid 234mL is diluted to 1000mL）24mL is added water to 1000mL is dissolving medium.Subsequent filtrate sample introduction is taken through miillpore filter respectively at 20,40,60min samplings 10mL, by test example 1 Chromatographic condition measure, measure the peak area of paracetamol, substitute into calibration curve equation, acquire corresponding dissolution rate, such as Shown in following table.
The measurement result of 1 embodiment of table and comparative example 1-2 dissolution rates
It is above-mentioned the experimental results showed that, the embodiment of the present invention prepare vitamin C Yinqiao tablet dissolve out 80% at 20 minutes, compared to comparison implementation Example 1 and 2, dissolution rate significantly improves, and illustrates vitamin C Yinqiao tablet dissolution prepared by the vitamin C Yinqiao tablet preparation method that this research provides Performance is good.
Test example 3
Vitamin C Yinqiao tablet stability is studied
The embodiment of the present invention and comparative example are stored in normal temperature condition, the 0th after producing respectively, 3,6,9,12,24 monthly tests The content for surveying vitamin C and paracetamol, as a result as shown in table 2 and table 3.
2 Vitaminc lonicera and forsythia product Vitamin C content study on the stability result of table
3 Vitaminc lonicera and forsythia product Determination Paracetamol in Paracetamol study on the stability result of table
It is above-mentioned the experimental results showed that, vitamin C Yinqiao tablet prepared by the present invention adds ubiquinone using polyvinyl alcohol10The tool prepared with glycerine There is the film coating of antioxidant activity so that the stability of vitamin C Yinqiao tablet improves；And further using the packaging material pair for the oxygen that blocks water Tablet vacuumizes rear inflated with nitrogen packaging, further ensures that drug is not oxidized, moisture absorption, increases its stability, embodiment is being made The 24th month after standby, the content of vitamin C and paracetamol influenced very little, and the vitamin C of comparative example and to second The content of acylamino- phenol is substantially reduced, and causes drug effect and quality decline, therefore, the packet of the nitrogen charging gas shielded of offer of the invention Dress method can improve the stability of vitamin C Yinqiao tablet, extend its shelf-life.

Claims (9)

1. a kind of vitamin C Yinqiao tablet of filling with inert gas packaging, which is characterized in that the tablet is packed and filled by the wall material for the oxygen that blocks water Inert gas shielding.
2. a kind of vitamin C Yinqiao tablet of filling with inert gas packaging according to claim 1, which is characterized in that the Vitaminc lonicera and forsythia Piece is prepared by the Chinese medicine and Western medicine of following weight proportion, 20-40 parts of Honeysuckle flower, 20-40 parts of Fructus Forsythiae, 8-16 parts of schizonepeta, light 10-20 parts of fermented soya bean, 8-12 parts of lophatherum gracile, 12-24 parts of great burdock achene, 12-24 parts of reed root, 12-24 parts of campanulaceae, 10-20 parts of Radix Glycyrrhizae, horse Sour chlorphenamine 0.117-0.234 parts next, 11.7-23.4 parts of paracetamol, 5.5-11 parts of vitamin C and peppermint oil dementholized 0.12-0.24 parts.
3. a kind of vitamin C Yinqiao tablet of filling with inert gas packaging according to claim 1, which is characterized in that described to block water Oxygen wall material is packaged as blister package.
4. a kind of vitamin C Yinqiao tablet of filling with inert gas packaging according to claim 4, which is characterized in that the blister pack Dress is that aluminium-plastics laminate layer body is constituted, and bottom plate is formed by cold forming paillon, is covered with the gold for the metal foil that can be open by tablet thereon Belong to layer closing packaging.
5. a kind of vitamin C Yinqiao tablet of filling with inert gas packaging according to claim 1, which is characterized in that the indifferent gas Body is one kind in nitrogen, helium, argon gas and carbon dioxide, preferably nitrogen.
6. a kind of vitamin C Yinqiao tablet of filling with inert gas packaging according to claim 1, which is characterized in that the tablet packet Containing disintegrant and diluent, the disintegrant is croscarmellose sodium, and diluent is dried starch.
7. a kind of vitamin C Yinqiao tablet of filling with inert gas packaging according to claim 1, which is characterized in that the tablet packet Containing adsorbent, the adsorbent is light magnesium oxide.
8. a kind of vitamin C Yinqiao tablet of filling with inert gas packaging according to claim 1, which is characterized in that the tablet can Film coating, optional 8% polyvinyl alcohol of film-coating constitutive material（PVA）Solution, 1.0% ubiquinone10With 0.7% glycerine.
9. according to the preparation method of the vitamin C Yinqiao tablet of the filling with inert gas packaging described in any of the above one, which is characterized in that every One tablet is placed in the blister of a oxygen that blocks water, and blister is vacuumized using nozzle-type vacuum plant, is used in combination and fills Tracheae, which fills under the atmosphere of indifferent gas, to be packed and seals.
CN201810163868.1A 2018-02-27 2018-02-27 A kind of vitamin C Yinqiao tablet of filling with inert gas packaging Pending CN108313367A (en)

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