CN108310016A - A kind of preparation method of external application cream for arthralgia - Google Patents
A kind of preparation method of external application cream for arthralgia Download PDFInfo
- Publication number
- CN108310016A CN108310016A CN201810424865.9A CN201810424865A CN108310016A CN 108310016 A CN108310016 A CN 108310016A CN 201810424865 A CN201810424865 A CN 201810424865A CN 108310016 A CN108310016 A CN 108310016A
- Authority
- CN
- China
- Prior art keywords
- arthralgia
- termite
- preparation
- external application
- mud
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
Abstract
The invention discloses it is a kind of for arthralgia external application cream preparation method, the specific steps are：Termite mud is dried, is then crushed, the termite mud powder after drying is immersed in acetum, and the acetum mass concentration is 60~65%, impregnates 8~10g termite muds in every 1ml acetums；Termite mud is taken out after immersion, termite mud after taking-up is placed in the water that temperature is 40~50 DEG C, then hydrogen peroxide is added dropwise thereto, the concentration of hydrogen peroxide is 3.0~3.5%, and the rate of addition of the hydrogen peroxide is 1~2 drop/sec, while dropwise addition, and termite mud is stirred repeatedly, while pH value is detected, when pH value is 6, stop that hydrogen peroxide is added dropwise, continues to stir；Then it is evaporated, sodium carboxymethylcellulose, maltodextrin is added into the residue after evaporation and stirs evenly to get to being applied with cream.
Description
Technical field
The invention belongs to biotechnologies, and in particular to a kind of preparation method of external application cream for arthralgia.
Background technology
Arthritis or arthropathy involve that range is very extensive, and type is various, and the cause of disease is different, and universal clinical symptoms can table
Existing arthralgia.Arthritis caused by any reason, as can seeing a doctor in time, symptomatic treatment generally can cure or alleviate.It is controlling
While treatment, it is also desirable to a kind of drug that can help to alleviate arthralgia in time.
Termitarium is commonly called as " termite mud ", is the loose mud block of brown or brown, is that worker ant builds the sand moved out out of nest when nest
Mud, the substance processed plus excreta and saliva.Long-pending thing of row is usually deposited in the periphery of nest.Such as doorframe both sides, beam or column and wall
Ground junction.Base is near the ground slightly has ant nest down for big tree base portion or tree.On trunk or branch crotch often just has the row of termite
Product object.
Fungus garden in termitarium is the excreta by termite, is gone out Archon bacterium made of through careful processing and through inoculated and cultured
Porous block object is that termite depends on for existence and indispensable, and the ant colony lacked in then nest will be dead.Fungus garden nutrition is rich
Richness is the optimal medium of Termitomyces albuminosus growth and development.According to《Compendium of Materia Medica》Described in：Termitomyces albuminosus smell " sweet flat, nontoxic ".It cures mainly
" beneficial stomach, controls hemorrhoid at clear god ".Research in recent years has shown that, 16 kinds of amino acid are contained in Termitomyces albuminosus bacterium, is very precious drug.
According to analysis, containing 16.5% protein, 4% pentosan, 20.91% ash content in fungus garden, and contain leucine, figured silk fabrics ammonia
10 kinds of amino acid such as acid, tyrosine, proline, alanine, threonine, arginine, lysine, glutamic acid, asparatate.This
A little amino acid have immeasurable medical value to treatment disease.However, in the prior art, the application about termitarium is not
It is more.
Invention content
Goal of the invention：Aiming at the deficiencies in the prior art, the present invention provides a kind of external applications for arthralgia
The preparation method of cream.
Technical solution：The present invention provides it is a kind of for arthralgia external application cream preparation method, the specific steps are：
Termite mud is dried, is then crushed, the termite mud powder after drying is immersed in acetum, the acetic acid
Concentration of polymer solution is 60~65%, impregnates 8~10g termite muds in every 1ml acetums；Termite mud is taken out after immersion, it will
Termite mud after taking-up is placed in the water that temperature is 40~50 DEG C, and hydrogen peroxide, the hydrogen peroxide are then added dropwise thereto
A concentration of 3.0~3.5%, the rate of addition of the hydrogen peroxide is 1~2 drop/sec, while dropwise addition, and to termite mud into
Row stirs repeatedly, while detecting pH value, when pH value is 6, stops that hydrogen peroxide is added dropwise, continues to stir；Then it is evaporated, to
Sodium carboxymethylcellulose, maltodextrin are added in residue after evaporation to stir evenly to get to being applied with cream.
Specifically, the termite mud is the loose mud block of brown or brown.
Specifically, the addition of the sodium carboxymethylcellulose, maltodextrin is 2~3% of residue after evaporating.
Specifically, the immersion, soaking time is 6~8 hours.The stirring, mixing time are 10~12 hours.
Specifically, the concentration of hydrogen peroxide is preferably 30%.The rate of addition of the hydrogen peroxide is preferably 1
Drop/sec.
Further to improve, the acetic acid soaking process is in ultrasound environments, and the ultrasound condition is：Ultrasonic work(
Rate is 60~100W；Ultrasonic temperature is 40~65 DEG C.
Advantageous effect, the present invention provides a kind of new ancillary drug for arthralgia, can be with while normal therapeutic
It is aided with external application cream provided by the present invention, can effectively alleviates arthralgia, while this product is naturally without side-effects.In addition, this
Invention also improves preparation method, effectively raises the efficiency of extraction, reduces preparation time.
Specific implementation mode：
Embodiment 1
Termite mud is dried, is then crushed, the termite mud powder after drying is immersed in acetum, the acetic acid
Concentration of polymer solution is 60~65%, and 8~10g termite muds are impregnated in every 1ml acetums, and soaking time is 8 hours；
Termite mud is taken out after immersion, the termite mud after taking-up is placed in the water that temperature is 40~50 DEG C, then to it
Middle dropwise addition hydrogen peroxide (a concentration of 3.0~3.5%), rate of addition are 1~2 drop/sec, while dropwise addition, and to termite mud into
Row stirs repeatedly, while detecting pH value, when pH value is 6, stops that hydrogen peroxide is added dropwise, continues to stir, and mixing time is 12 small
When；
It is evaporated, sodium carboxymethylcellulose is added into the residue after evaporation, maltodextrin stirs evenly, carboxymethyl
Sodium cellulosate, maltodextrin addition be evaporation after residue 2~3% to get to be applied with cream.
Embodiment 2
Basic step is roughly the same with embodiment 1, the difference is that, soaking time is changed to 6 hours.
Embodiment 3
Basic step is roughly the same with embodiment 2, the difference is that, soaking time is changed to 4 hours.
Embodiment 4
Basic step is roughly the same with embodiment 2, the difference is that, soaking time is changed to 3 hours.
Embodiment 5
Basic step is roughly the same with embodiment 2, the difference is that, soaking time is changed to 2 hours.
The quality of termite mud with the quality of the residue after evaporation and after drying is divided by calculate recovery rate, and difference is impregnated
The influence of time and mixing time to recovery rate, data are as shown in the table：
| Soaking time (h) | Recovery rate (%) | |
| Embodiment 1 | 8 | 71 |
| Embodiment 2 | 6 | 70 |
| Embodiment 3 | 4 | 68 |
| Embodiment 4 | 3 | 46 |
| Embodiment 5 | 2 | 33 |
It can be seen that when soaking time is reduced from above-described embodiment and data, recovery rate continuously decreases.When less than
After 4 hours, there will be prodigious wastes
Embodiment 6
Termite mud is dried, is then crushed, the termite mud powder after drying is immersed in acetum, the acetic acid
Concentration of polymer solution is 60~65%, and 8~10g termite muds are impregnated in every 1ml acetums, and soaking time is 8 hours；It impregnated
Journey is in ultrasound environments, and ultrasound condition is：Ultrasonic power is 60~100W；Ultrasonic temperature is 40~65 DEG C.Mixing time is 4
Hour；
Termite mud is taken out after immersion, the termite mud after taking-up is placed in the water that temperature is 40~50 DEG C, then to it
Middle dropwise addition hydrogen peroxide (a concentration of 3.0~3.5%), rate of addition are 1~2 drop/sec, while dropwise addition, and to termite mud into
Row stirs repeatedly, while detecting pH value, when pH value is 6, stops that hydrogen peroxide is added dropwise, continues to stir, and mixing time is 12 small
When；
It is evaporated, sodium carboxymethylcellulose is added into the residue after evaporation, maltodextrin stirs evenly, carboxymethyl
Sodium cellulosate, maltodextrin addition be evaporation after residue 2~3% to get to be applied with cream.
Embodiment 7
Basic step is roughly the same with embodiment 6, the difference is that, soaking time is changed to 6 hours.
Embodiment 8
Basic step is roughly the same with embodiment 6, the difference is that, soaking time is changed to 4 hours.
Embodiment 9
Basic step is roughly the same with embodiment 6, the difference is that, soaking time is changed to 3 hours.
Embodiment 10
Basic step is roughly the same with embodiment 6, the difference is that, soaking time is changed to 2 hours.
| Soaking time (h) | Recovery rate (%) | |
| Embodiment 6 | 8 | 80 |
| Embodiment 7 | 6 | 76 |
| Embodiment 8 | 4 | 70 |
| Embodiment 9 | 3 | 68 |
| Embodiment 10 | 2 | 65 |
It can be seen that under ultrasound environments from above-described embodiment and experimental result, can effectively reduce soaking time, and
Greatly improve the efficiency of extraction.
Embodiment 11 (application)
The external application cream that 1~embodiment of embodiment, 10 the method is prepared is supplied to the patient of arthralgia to carry out
It is applied with, after 12 hours, patient pain is substantially reduced.
Claims (8)
1. a kind of preparation method of external application cream for arthralgia, it is characterised in that include the following steps：
Termite mud is dried, is then crushed, the termite mud powder after drying is immersed in acetum, the acetum
Mass concentration is 60~65%, impregnates 8~10g termite muds in every 1ml acetums；Termite mud is taken out after immersion, will be taken out
Termite mud afterwards is placed in the water that temperature is 40~50 DEG C, and hydrogen peroxide, the concentration of hydrogen peroxide are then added dropwise thereto
It is 3.0~3.5%, the rate of addition of the hydrogen peroxide is 1~2 drop/sec, while dropwise addition, and is carried out to termite mud anti-
Multiple stirring, while pH value is detected, when pH value is 6, stops that hydrogen peroxide is added dropwise, continue to stir；Then it is evaporated, to evaporation
Sodium carboxymethylcellulose, maltodextrin are added in residue afterwards to stir evenly to get to being applied with cream.
2. the preparation method of the external application cream according to claim 1 for arthralgia, it is characterised in that the termite
Mud is the loose mud block of brown or brown.
3. the preparation method of the external application cream according to claim 1 for arthralgia, it is characterised in that carboxymethyl cellulose
Plain sodium, maltodextrin addition be evaporation after residue 2~3%.
4. the preparation method of the external application cream according to claim 1 for arthralgia, it is characterised in that the immersion,
Soaking time is 6~8 hours.
5. the preparation method of the external application cream according to claim 1 for arthralgia, it is characterised in that the stirring,
Mixing time is 10~12 hours.
6. the preparation method of the external application cream according to claim 1 for arthralgia, it is characterised in that the peroxide
It is 30% to change hydrogen concentration.
7. the preparation method of the external application cream according to claim 1 for arthralgia, it is characterised in that the peroxide
The rate of addition for changing hydrogen is 1 drop/sec.
8. the preparation method of the external application cream according to claim 1 for arthralgia, it is characterised in that the acetic acid
Soaking process is in ultrasound environments, and the ultrasound condition is：Ultrasonic power is 60~100W；Ultrasonic temperature is 40~65
℃。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810424865.9A CN108310016A (en) | 2018-05-07 | 2018-05-07 | A kind of preparation method of external application cream for arthralgia |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810424865.9A CN108310016A (en) | 2018-05-07 | 2018-05-07 | A kind of preparation method of external application cream for arthralgia |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108310016A true CN108310016A (en) | 2018-07-24 |
Family
ID=62895678
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810424865.9A Pending CN108310016A (en) | 2018-05-07 | 2018-05-07 | A kind of preparation method of external application cream for arthralgia |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4282489A (en) * | 1988-10-10 | 1990-04-12 | Robert Loxton | Medical remedial uses of termites and their nests |
| CN101757614A (en) * | 2010-02-22 | 2010-06-30 | 苏州汇涵医用科技发展有限公司 | Hemostat and preparation method thereof |
| CN106727920A (en) * | 2016-12-23 | 2017-05-31 | 江苏苏南药业实业有限公司 | A kind of preparation method of compound termitarium particle |
| CN107137488A (en) * | 2017-05-27 | 2017-09-08 | 江苏苏南药业实业有限公司 | A kind of compound termitarium particle of anti-osteoarthritis |
| CN107245429A (en) * | 2017-08-11 | 2017-10-13 | 句容市森林白蚁防治研究所 | A kind of termitarium vinegar and its preparation method and application |
-
2018
- 2018-05-07 CN CN201810424865.9A patent/CN108310016A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4282489A (en) * | 1988-10-10 | 1990-04-12 | Robert Loxton | Medical remedial uses of termites and their nests |
| CN101757614A (en) * | 2010-02-22 | 2010-06-30 | 苏州汇涵医用科技发展有限公司 | Hemostat and preparation method thereof |
| CN106727920A (en) * | 2016-12-23 | 2017-05-31 | 江苏苏南药业实业有限公司 | A kind of preparation method of compound termitarium particle |
| CN107137488A (en) * | 2017-05-27 | 2017-09-08 | 江苏苏南药业实业有限公司 | A kind of compound termitarium particle of anti-osteoarthritis |
| CN107245429A (en) * | 2017-08-11 | 2017-10-13 | 句容市森林白蚁防治研究所 | A kind of termitarium vinegar and its preparation method and application |
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Application publication date: 20180724 |
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| RJ01 | Rejection of invention patent application after publication |