CN108309319A - A kind of Woundless blood sugar continues to monitor device - Google Patents
A kind of Woundless blood sugar continues to monitor device Download PDFInfo
- Publication number
- CN108309319A CN108309319A CN201810047925.XA CN201810047925A CN108309319A CN 108309319 A CN108309319 A CN 108309319A CN 201810047925 A CN201810047925 A CN 201810047925A CN 108309319 A CN108309319 A CN 108309319A
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- China
- Prior art keywords
- electrode
- layer
- sensor
- blood sugar
- monitor device
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase
Abstract
The invention discloses a kind of Woundless blood sugars to continue to monitor device, including outer housing, the cover board being set on outer housing and the blood sugar test probe for being set on outer housing and being oppositely arranged with cover board, cover board has the accommodating cavity for placing finger, blood sugar test probe includes matrix and is set to the first sensor and second sensor of matrix one end, first sensor includes the first working electrode, first reference electrode and the first auxiliary electrode, second sensor includes the second working electrode, second reference electrode and the second auxiliary electrode, first working electrode includes the first inert electrode layer set gradually, graphene layer, metal nano-particle layer and glucose oxidase layer, second working electrode includes the second inert electrode layer set gradually, graphene layer, metal nano-particle layer and glucose oxidase layer.The Woundless blood sugar of the present invention continues to monitor device, can improve the glucose concentration measurement precision of diabetic.
Description
Technical field
The invention belongs to technical field of medical equipment, specifically, the present invention relates to a kind of Woundless blood sugars to continue to monitor dress
It sets.
Background technology
Diabetes are one of the most important Chronic Non-Communicable Diseases of current threat global human health, according to international sugar
The recent statistics of Niao Bing alliances, up to 3.82 hundred million, wherein China diabetic number is up to global diabetic's number
1.14 hundred million.The harm of diabetes is huge, other than being difficult to thoroughly effect a radical cure, the serious complication such as diabetes caused by diabetes
Nephrosis, diabetic cataract, diabetes etc. seriously threaten the health and lives safety of patient.For patient of diabetes
Person, control blood glucose is currently the only effective treatment means.So the accurate detection of blood sugar for human body be very it is necessary to, to
So that blood glucose measurement device becomes the medical product of each diabetic indispensability, and blood glucose measurement probe is that blood glucose measurement is set
Standby most crucial component.
In the implementation of the present invention, the inventor finds that the existing technology has at least the following problems：Existing Woundless blood sugar
The accuracy of detection of the probe of monitoring device is relatively low, can not achieve the accurate measurement of the concentration of glucose of diabetic.
Invention content
The present invention is directed at least solve one of the technical problems existing in the prior art.For this purpose, the present invention provides a kind of nothing
Wound blood glucose continues to monitor device, it is therefore an objective to improve glucose concentration measurement precision.
To achieve the goals above, the technical solution that the present invention takes is：A kind of Woundless blood sugar continues to monitor device, including
Outer housing, the cover board being set on outer housing and the blood sugar test probe for being set on outer housing and being oppositely arranged with cover board, lid
There is plate the accommodating cavity for placing finger, blood sugar test probe to include matrix and be set to the first sensor of matrix one end and the
Two sensors, first sensor include that the first working electrode, the first reference electrode and the first auxiliary electrode, second sensor include
Second working electrode, the second reference electrode and the second auxiliary electrode, first working electrode include set gradually it is first lazy
Property electrode layer, graphene layer, metal nano-particle layer and glucose oxidase layer, second working electrode include set gradually
The second inert electrode layer, graphene layer, metal nano-particle layer and glucose oxidase layer.
First reference electrode and second reference electrode are Ag/AgCl electrodes.
First auxiliary electrode and second auxiliary electrode are platinum electrode.
Described matrix be equipped with the first insulating layer for surrounding the first sensor and surround the second sensor the
Two insulating layers.
The material of first insulating layer and the second insulating layer is ink.
The Woundless blood sugar of the present invention continues to monitor device, by the way that graphene layer, gold are arranged on the working electrode of sensor
Metal nano-particle layer and glucose oxidase layer enhance the electric conductivity of working electrode, enhance the sensitivity and survey of sensor
Accuracy of measurement, so as to improve the glucose concentration measurement precision of diabetic.
Description of the drawings
This specification includes the following drawings, and shown content is respectively：
Fig. 1 is the structural schematic diagram that Woundless blood sugar of the present invention continues to monitor device；
Fig. 2 is the structural schematic diagram of blood sugar test probe；
Fig. 3 is the structural schematic diagram of the end of probe of blood sugar test probe；
Fig. 4 is the structural schematic diagram of the feeder ear of blood sugar test probe；
Fig. 5 is the sectional view of the first working electrode and the second working electrode；
In figure label for：1, the first tera-hertz spectra module；2, matrix；3, first sensor；301, the first working electrode；
302, the first reference electrode；303, the first auxiliary electrode；304, the first inert electrode layer；305, graphene layer；306, metal is received
Rice grain layer；307, glucose oxidase layer；4, second sensor；401, the second working electrode；402, the second reference electrode；
403, the second auxiliary electrode；404, the second inert electrode layer；405, graphene layer；406, metal nano-particle layer；407, grape
Oxidase enzyme layer；5, the second tera-hertz spectra module；6, electrode；7, electrode；8, electrode；9, electrode；10, electrode；11, electrode；
12, electrode；13, electrode；14, electrode；15, electrode；16, controller；17, the first insulating layer；18, second insulating layer；19, shell
Body；20, cover board；21, accommodating cavity.
Specific implementation mode
Below against attached drawing, by the description of the embodiment, making to the specific implementation mode of the present invention further details of
Explanation, it is therefore an objective to those skilled in the art be helped to have more complete, accurate and deep reason to the design of the present invention, technical solution
Solution, and contribute to its implementation.
It should be noted that in embodiment disclosed below, " first ", " second " and " third " does not represent knot
Structure and/or absolute differentiation relationship functionally, do not represent the sequence that executes of priority yet, and merely for convenience of description.
As shown in Figures 1 to 5, the present invention provides a kind of Woundless blood sugars to continue to monitor device, including outer housing 19, control
Device 16, the cover board 20 being set on outer housing 19 and the blood sugar test spy for being set on outer housing 19 and being oppositely arranged with cover board 20
There is the accommodating cavity 21 for placing finger, controller to be integrated on blood sugar test probe for head, cover board 20.The main packet of blood sugar test probe
Include matrix 2, first sensor 3, second sensor 4, the first tera-hertz spectra module 1 and the second tera-hertz spectra module 5, first
Sensor 3 and second sensor 4 are set to one end of matrix 2, and controller 16 is set to the other end of matrix 2, the first Terahertz
Spectroscopic module 1, the second tera-hertz spectra module 5 are set to the same end of matrix 2 with controller.First sensor 3 and second passes
Sensor 4 is electrochemical sensor, and the structure of first sensor 3 and second sensor 4 is essentially identical.First sensor 3 includes the
One working electrode 301, the first reference electrode 302 and the first auxiliary electrode 303, second sensor 4 include the second working electrode
401, the second reference electrode 402 and the second auxiliary electrode 403, the first working electrode 301 include the first inertia electricity set gradually
Pole layer 304, graphene layer 305, metal nano-particle layer 306 and glucose oxidase layer 307, the second working electrode 401 include
The second inert electrode layer 404, graphene layer 405, metal nano-particle layer 406 and the glucose oxidase layer 407 set gradually.
Specifically, as shown in Figure 1, cover board 20 is set to the top of outer housing 19, cover board 20 is rotation with outer housing 19
Connection, cover board 20 can be rotated upwardly and downwardly relative to outer housing 19, and cover board 20 is the structure of one end open and inner hollow, cover board 20
Hollow cavity be the accommodating cavity 21 for accommodating human finger, the opening of the end set of cover board 20 is for making human finger logical
It crosses.Blood sugar test, which is popped one's head in, is set to the inside of outer housing 19, and blood sugar test pops one's head in and is located at the lower section of accommodating cavity 21, blood sugar test
First sensor 3 and second sensor 4 on probe with human finger for contacting.
As shown in Figures 2 to 4, first sensor 3 and second sensor 4 are set to the end of probe of matrix 2, the first Terahertz
Spectroscopic module 1 and the second tera-hertz spectra module 5 are set to the feeder ear of matrix 2, end of probe and the length that feeder ear is matrix 2
Opposite end on direction, the first tera-hertz spectra module 1 and the second tera-hertz spectra module 5 are for generating THz wave.Base
Body 2 is also equipped with electrode 6, electrode 7, electrode 8, electrode 9, electrode 10, electrode 11, electrode 12, electrode 13, electrode 14 and electrode
15, electrode 10 is electrically connected by conducting wire with the first reference electrode 302, and electrode 11 is electrically connected by conducting wire and the first working electrode 301
It connects, electrode 12 is electrically connected by conducting wire with the first auxiliary electrode 303, and electrode 13 is electrically connected by conducting wire and the second reference electrode 402
It connects, electrode 14 is electrically connected by conducting wire with the second working electrode 401, and electrode 15 is electrically connected by conducting wire and the second auxiliary electrode 403
It connects.Electrode 6, electrode 7, electrode 8, electrode 9, electrode 10, electrode 11, electrode 12, electrode 13, electrode 14 and electrode 15 and with control
Device is electrical connection, and electrode 6 and electrode 7 connect with the first tera-hertz spectra module 1, electrode 8 and electrode 9 and the second tera-hertz spectra
Module 5 connects, and the structure of the first tera-hertz spectra module 1 and the second tera-hertz spectra module 5 is such as those skilled in the art institute
As known, therefore details are not described herein.The operation principle of blood sugar test probe is consistent with the prior art, blood sugar test probe work
When making, the detection end in contact human skin of matrix 2, electrode 12 is set to load positive operating voltage, the load of electrode 15 is born operating voltage, driven
It is dynamic to work the first auxiliary electrode 303 and the second auxiliary electrode 403, carry out the Portugal in reverses iontophoresis transdermal extraction tissue fluid
Grape sugar.After first tera-hertz spectra module 1 and the second tera-hertz spectra module 5 are powered, the THz wave of specific frequency is generated, and
Human skin surface is acted on, the reverses iontophoresis sampling enhanced based on Terahertz is completed.
As shown in Figure 3 and Figure 5, the first auxiliary electrode 303 is C-shaped, and the first working electrode 301 is circle, the first work electricity
Pole 301 is located at the center of the first auxiliary electrode 303, and the first auxiliary electrode 303 surrounds the first working electrode 301, the first reference
Electrode 302 is located at the indentation, there of the first auxiliary electrode 303 and the first reference electrode 302 is located at the first auxiliary electrode 303 and first
Between working electrode 301.Preferably, the first working electrode 301 is stepped construction, set successively on the first working electrode 301
It is equipped with graphene layer 305, metal nano-particle layer 306 and glucose oxidase layer 307, the spirit of first sensor 3 can be improved
Sensitivity and accuracy of detection.First inert electrode layer 304 is modified using graphene layer 305 and metal nano-particle layer 306,
Achieve the purpose that improve sensor accuracy class and sensitivity.Graphene layer 305 is will to be sunk using microwave plasma chemical gas phase
The graphene that product method obtains moves on on the surface of the first inert electrode layer 304, obtains the graphene layer in three-dimensional porous structure
305.Metal nano-particle layer 306 is to be immersed in the electrolyte containing corresponding metal salt to utilize electrochemical deposition by electrode
What method obtained, and be grown on the surface of graphene layer 305.Graphene layer 305 is in three-dimensional porous structure, is nano particle
Deposition provides good condition.Glucose oxidase layer 307 is solidificated on the surface of metal nano-particle layer 306, can
Realize that the specificity of glucose measures, glucose oxidase layer 307 is by being immersed in electrode containing glucose oxidase
It is obtained using the method for electrochemical deposition in electrolyte.First reference electrode 302 is Ag/AgCl electrodes, the first auxiliary electrode
303 be platinum electrode.
As shown in Figure 3 and Figure 5, the second auxiliary electrode 403 is C-shaped, and the second working electrode 401 is circle, the second work electricity
Pole 401 is located at the center of the second auxiliary electrode 403, and the second auxiliary electrode 403 surrounds the second working electrode 401, the second reference
Electrode 402 is located at the indentation, there of the second auxiliary electrode 403 and the second reference electrode 402 is located at the second auxiliary electrode 403 and second
Between working electrode 401.Preferably, the second working electrode 401 is stepped construction, set successively on the second working electrode 401
It is equipped with graphene layer 405, metal nano-particle layer 406 and glucose oxidase layer 407, the spirit of second sensor 4 can be improved
Sensitivity and accuracy of detection.Second inert electrode layer 404 is modified using graphene layer 405 and metal nano-particle layer 406,
Achieve the purpose that improve sensor accuracy class and sensitivity.Graphene layer 405 is will to be sunk using microwave plasma chemical gas phase
The graphene that product method obtains moves on on the surface of the second inert electrode layer 404, obtains the graphene layer in three-dimensional porous structure
405.Metal nano-particle layer 406 is to be immersed in the electrolyte containing corresponding metal salt to utilize electrochemical deposition by electrode
What method obtained, and be grown on the surface of graphene layer 405.Graphene layer 405 is in three-dimensional porous structure, is nano particle
Deposition provides good condition.Glucose oxidase layer 407 is solidificated on the surface of metal nano-particle layer 406, can
Realize that the specificity of glucose measures, glucose oxidase layer 407 is by being immersed in electrode containing glucose oxidase
It is obtained using the method for electrochemical deposition in electrolyte.Second reference electrode 402 is Ag/AgCl electrodes, the second auxiliary electrode
403 be platinum electrode.
As shown in figure 3, preferably, matrix 2 is equipped with the first insulating layer 17 for surrounding first sensor 3 and surrounds the
The second insulating layer 18 of two sensors 4.First insulating layer 17 is set on the end face of matrix 2, and the first insulating layer 17 and first passes
Sensor 3 is set to the same end of matrix 2, and the first insulating layer 17 is with certain thickness, the first insulating layer 17 and is circular ring shape knot
Structure, first sensor 3 are located at the center of the first insulating layer 17, and the first insulating layer 17 surrounds first sensor 3, to avoid tissue
Liquid stream is lost.Second insulating layer 18 is set on the end face of matrix 2, and second insulating layer 18 and second sensor 4 are set to matrix 2
The same end, second insulating layer 18 is with certain thickness, second insulating layer 18 and is cirque structure, and second sensor 4 is located at
At the center of second insulating layer 18, second insulating layer 18 surrounds second sensor 4, is lost in avoid tissue fluid.First insulating layer
17 and the material of second insulating layer 18 be preferably ink, insulation effect is good.The setting of first insulating layer 17 and second insulating layer 18,
It can be interfered with each other to avoid between first sensor 3 and second sensor 4, it is ensured that measurement accuracy.
The present invention is exemplarily described above in association with attached drawing.Obviously, present invention specific implementation is not by above-mentioned side
The limitation of formula.As long as using the improvement of the various unsubstantialities of inventive concept and technical scheme of the present invention progress；Or not
It is improved, the above-mentioned design of the present invention and technical solution are directly applied into other occasions, in protection scope of the present invention
Within.
Claims (5)
1. a kind of Woundless blood sugar continues to monitor device, including outer housing, the cover board that is set on outer housing and it is set to outer housing
Blood sugar test that is upper and being oppositely arranged with cover board is popped one's head in, and cover board has the accommodating cavity for placing finger, and blood sugar test probe includes base
Body and the first sensor and second sensor for being set to matrix one end, first sensor include the first working electrode, first
Reference electrode and the first auxiliary electrode, second sensor include the second working electrode, the second reference electrode and the second auxiliary electrode,
It is characterized in that：First working electrode includes the first inert electrode layer, graphene layer, the metal nanoparticle set gradually
Layer and glucose oxidase layer, second working electrode include the second inert electrode layer, graphene layer, the metal set gradually
Nano-particle layer and glucose oxidase layer.
2. Woundless blood sugar according to claim 1 continues to monitor device, it is characterised in that：First reference electrode and institute
It is Ag/AgCl electrodes to state the second reference electrode.
3. Woundless blood sugar according to claim 2 continues to monitor device, it is characterised in that：First auxiliary electrode and institute
It is platinum electrode to state the second auxiliary electrode.
4. Woundless blood sugar according to any one of claims 1 to 3 continues to monitor device, it is characterised in that：It is set in described matrix
There is the first insulating layer for surrounding the first sensor and surrounds the second insulating layer of the second sensor.
5. Woundless blood sugar according to claim 4 continues to monitor device, it is characterised in that：First insulating layer and described
The material of second insulating layer is ink.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810047925.XA CN108309319A (en) | 2018-01-18 | 2018-01-18 | A kind of Woundless blood sugar continues to monitor device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810047925.XA CN108309319A (en) | 2018-01-18 | 2018-01-18 | A kind of Woundless blood sugar continues to monitor device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108309319A true CN108309319A (en) | 2018-07-24 |
Family
ID=62895047
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810047925.XA Withdrawn CN108309319A (en) | 2018-01-18 | 2018-01-18 | A kind of Woundless blood sugar continues to monitor device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108309319A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2587656A (en) * | 2019-10-04 | 2021-04-07 | Etouch Medical Inc | Non-Invasive system for testing blood sugar and method of the same |
-
2018
- 2018-01-18 CN CN201810047925.XA patent/CN108309319A/en not_active Withdrawn
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2587656A (en) * | 2019-10-04 | 2021-04-07 | Etouch Medical Inc | Non-Invasive system for testing blood sugar and method of the same |
| GB2587656B (en) * | 2019-10-04 | 2021-09-22 | Etouch Medical Inc | Non-Invasive system for testing blood glucose and method of the same |
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Application publication date: 20180724 |