CN108300662A - A kind of immunocyte amplification in vitro kit - Google Patents
A kind of immunocyte amplification in vitro kit Download PDFInfo
- Publication number
- CN108300662A CN108300662A CN201810170624.6A CN201810170624A CN108300662A CN 108300662 A CN108300662 A CN 108300662A CN 201810170624 A CN201810170624 A CN 201810170624A CN 108300662 A CN108300662 A CN 108300662A
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- CN
- China
- Prior art keywords
- box body
- test tube
- loading plate
- plate
- box
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/08—Flask, bottle or test tube
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/48—Holding appliances; Racks; Supports
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Sustainable Development (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Clinical Laboratory Science (AREA)
- Buffer Packaging (AREA)
Abstract
The present invention relates to kit technical fields, especially a kind of immunocyte amplification in vitro kit, including box body, it is hinged with box cover at the top of the box body, the tray interior level is equipped with loading plate, multiple test tube jacks are offered on the loading plate, test tube jack bottom is along the circumferential direction equidistant to be vertically connected with more connecting rods, the more one end of the connecting rod far from loading plate are connected with spacing ring corresponding with test tube jack jointly, and the both ends of the loading plate are arranged with buffer unit.The configuration of the present invention is simple, it is easy to use, there is good damping effect, while effectively being protected to test tube.
Description
Technical field
The present invention relates to kit technical field more particularly to a kind of immunocyte amplification in vitro kits.
Background technology
Natural killer cells is the important immunocyte of body, is not only had with antitumor, viral infection resisting and immunological regulation
It closes, and participates in the generation of hypersensitivity and autoimmune disease in some cases.NK cells are in antiviral and antitumor
Important role is played, because its effect is not required to initial immunity activation, therefore before having prodigious application in adoptive immunotherapy
Scape.Immunization therapy is carried out using NK cells, needing to expand in vitro first largely has NK cells active compared with High Fragmentation.But
Existing NK cell expansion ex vivos reagent cartridge configuration is fixed, and internal Reagent Tube is easy collision in moving process, so as to cause
Reagent Tube is damaged.
Invention content
The purpose of the present invention is to solve the disadvantages that structure fixation exists in the prior art, and the one kind proposed is immune thin
Born of the same parents' amplification in vitro kit.
To achieve the goals above, present invention employs following technical solutions：
A kind of immunocyte amplification in vitro kit, including box body are designed, is hinged with box cover at the top of the box body, feature exists
In the tray interior level is equipped with loading plate, and multiple test tube jacks, test tube jack bottom are offered on the loading plate
Along the circumferential direction equidistant to be vertically connected with more connecting rods, the more one end of the connecting rod far from loading plate are connected with jointly
The both ends of spacing ring corresponding with test tube jack, the loading plate are arranged with buffer unit, and the buffer unit includes perpendicular
Head straight for being located at the sliding slot on inboard wall of cartridge, the sliding slot internal slide is equipped with sliding block, and the loading plate end is fixed with sliding block
The lower horizontal of connection, the loading plate is equipped with support plate, and the support plate is fixedly connected on inboard wall of cartridge, the support plate
Bottom both ends are equipped with T-bar, and one end of the T-bar runs through support plate and end is commonly connected to the bottom of loading plate,
It being arranged respectively on the T-bar there are two rubber spring, two rubber springs are located at the top and bottom of support plate,
Pressurizing unit and lifting apparatus are respectively equipped with above and below the loading plate, the bottom of the box body is equipped with chlorination equipment.
Preferably, the lifting apparatus includes supporting plate, and the both ends of the supporting plate are arranged with sliding equipment, the skate machine
Structure includes two pieces of limiting plates, and two pieces of limiting plates are connected horizontally on the inner wall of box body, between two pieces of limiting plates etc.
Distance is connected with more slide bars, is slidably connected between the supporting plate and multiple slide bars, on the slide bar of the upper and lower ends of the supporting plate
It is arranged with second spring, the second foam-rubber cushion is equipped in the upper surface of the supporting plate.
Preferably, the pressurizing unit includes U-shaped pull rod, and the both ends of the U-shaped pull rod run through box cover and end is common
It is connected with pressing plate, the both ends of the U-shaped pull rod are arranged with the first spring, and the both ends of first spring are connected to box cover
Bottom end and pressing plate upper surface are equipped with the first foam-rubber cushion in the pressing plate bottom.
Preferably, the chlorination equipment includes the disinfection box not bound, and the disinfection box is fixedly connected on box body bottom, and
The disinfection box is connected to tray interior, and more sterilization pipes are equipped with inside the disinfection box.
Preferably, the outside of the disinfection box is equipped with charging interface, passes through conducting wire between the charging interface and sterilization pipe
Connection.
Preferably, the box body bottom four corners are installed with foot pad.
Preferably, the both ends of U-shaped pull rod have been connected through a screw thread adjusting nut at the top of the box cover.
Preferably, it is mounted on rubber ring on the inside of the test tube jack.
A kind of immunocyte amplification in vitro kit proposed by the present invention, advantageous effect are：By immunocyte test tube into
Row is inserted into inside test tube jack, is limited by spacing ring, inclined to effectively avoid test tube, then is distinguished
In the process of moving, test tube can be subtracted to be clamped fixation to test tube by pressurizing unit and lifting apparatus
Shake buffering, reduces the possibility mutually collided between test tube.The configuration of the present invention is simple, it is easy to use, there is good damping
Effect, while effectively test tube is protected.
Description of the drawings
Fig. 1 is a kind of structural schematic diagram of immunocyte amplification in vitro kit proposed by the present invention；
Fig. 2 is a kind of slide bar of immunocyte amplification in vitro kit proposed by the present invention and support board structure schematic diagram；
Fig. 3 is enlarged structure schematic diagram at A in Fig. 1；
Fig. 4 is a kind of loading plate overlooking structure diagram of immunocyte amplification in vitro kit proposed by the present invention.
In figure：Box body 1, support plate 2, sliding block 3, sliding slot 4, loading plate 5, box cover 6, pressing plate 7, adjusting nut 8, the first sponge
Pad 9, U-shaped pull rod 10, the first spring 11, test tube jack 12, rubber spring 13, T-bar 14, limiting plate 15, foot pad 16, spacing ring
17, connecting rod 18, supporting plate 19, disinfection box 20, sterilization pipe 21, charging interface 22, slide bar 23, second spring 24, rubber ring 25,
Two foam-rubber cushions 26.
Specific implementation mode
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation describes, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.
Referring to Fig.1-4, a kind of immunocyte amplification in vitro kit, including box body 1, the fixed peace of 1 bottom four corners of box body
Equipped with foot pad 16, the top of box body 1 is hinged with box cover 6, and 1 inner horizontal of box body is equipped with loading plate 5, is offered on loading plate 5 more
A test tube jack 12,12 inside of test tube jack are mounted on rubber ring 25, and 12 bottom of test tube jack is along the circumferential direction equidistant to hang down
Direct-connected to be connected to more connecting rods 18, the more one end of connecting rod 18 far from loading plate 5 are connected with opposite with test tube jack 12 jointly
The both ends of the spacing ring 17 answered, loading plate 5 are arranged with buffer unit, and buffer unit includes being opened on 1 inner wall of box body vertically
Sliding slot 4,4 internal slide of sliding slot is equipped with sliding block 3, and 5 end of loading plate is fixedly connected with sliding block 3, the lower horizontal of loading plate 5
Equipped with support plate 2, support plate 2 is fixedly connected on 1 inner wall of box body, and 2 bottom both ends of support plate are equipped with T-bar 14, T-bar 14
One end run through the bottom that support plate 2 and end are commonly connected to loading plate 5, be arranged that there are two rubber on T-bar 14 respectively
Spring 13, two rubber springs 13 are located at 2 top and bottom of support plate, are respectively equipped with above and below loading plate 5
The bottom of pressurizing unit and lifting apparatus, box body 1 is equipped with chlorination equipment, and chlorination equipment includes the disinfection box 20 not bound, disinfection
Box 20 is fixedly connected on 1 bottom of box body, and disinfection box 20 is connected to 1 inside of box body, and more disinfections are equipped with inside disinfection box 20
The outside of pipe 21, disinfection box 20 is equipped with charging interface 22, is connected to by conducting wire between charging interface 22 and sterilization pipe 21；It will be immunized
Cell test tube be inserted into inside test tube jack 12, is limited by spacing ring 17, is in effectively avoid test tube
Heeling condition, by rubber ring 25, so as to prevent loading plate 5 from causing to damage to test tube, by rubber spring 13, so as to
Box cover 6 is covered after test tube is placed to play the role of preliminary damping to test tube, by charging interface 22, to sterilization pipe
21 are powered, to the sterilizing that carries out disinfection inside box body 1.
Lifting apparatus includes supporting plate 19, and the both ends of supporting plate 19 are arranged with sliding equipment, and sliding equipment includes two pieces of limits
Plate 15, two pieces of limiting plates 15 are connected horizontally on the inner wall of box body 1, equidistant between two pieces of limiting plates 15 to be connected with more cunnings
Bar 23 is slidably connected between supporting plate 19 and multiple slide bars 23, and the second bullet is arranged on the slide bar 23 of the upper and lower ends of supporting plate 19
Spring 24 is equipped with the second foam-rubber cushion 26 in the upper surface of supporting plate 19, and pressurizing unit includes U-shaped pull rod 10, the both ends of U-shaped pull rod 10
Run through box cover 6 and end is connected with pressing plate 7 jointly, the both ends of U-shaped pull rod 10 are arranged with the first spring 11, the first spring 11
Both ends be connected to 7 upper surface of 6 bottom end of box cover and pressing plate, the both ends of the U-shaped pull rod in 6 top of box cover 10 are connected through a screw thread
There is adjusting nut 8, the first foam-rubber cushion 9 is equipped in 7 bottom of pressing plate；When test tube is placed on test tube 12 inside of jack, 19 meeting of supporting plate
The bottom of test tube is lifted, while the second foam-rubber cushion 26 can prevent supporting plate 19 from causing to damage to test tube, cover box cover 6, pressed
Plate 7 moves down, while squeezing test tube, and the first spring 11 is in compressive state, by supporting plate 19 and pressing plate 7, thus will
Test tube is clamped fixation, effectively avoids and mutually collides between test tube, while by second spring 24 and the first spring 11,
To carry out bumper and absorbing shock to test tube again, by adjusting nut 8, so as to the height according to the length of test tube to pressing plate 7
It is adjusted, the extruding force for avoiding pressing plate 7 excessive causes to damage to test tube.
Embodiment：Immunocyte test tube be inserted into inside test tube jack 12, is limited by spacing ring 17,
It is inclined to effectively avoid test tube, then respectively by pressurizing unit and lifting apparatus, to be pressed from both sides to test tube
It fastens, in the process of moving, damping, buffering can be carried out to test tube, reduce the possibility mutually collided between test tube.
The foregoing is only a preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto,
Any one skilled in the art in the technical scope disclosed by the present invention, according to the technique and scheme of the present invention and its
Inventive concept is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.
Claims (8)
1. a kind of immunocyte amplification in vitro kit, including box body（1）, the box body（1）Top be hinged with box cover（6）,
It is characterized in that, the box body（1）Inner horizontal is equipped with loading plate（5）, the loading plate（5）On offer multiple test tube jacks
（12）, the test tube jack（12）Bottom is along the circumferential direction equidistant to be vertically connected with more connecting rods（18）, the more companies
Extension bar（18）Far from loading plate（5）One end be connected with jointly and test tube jack（12）Corresponding spacing ring（17）, described to hold
Support plate（5）Both ends be arranged with buffer unit, the buffer unit includes being opened in box body vertically（1）Sliding slot on inner wall
（4）, the sliding slot（4）Internal slide is equipped with sliding block（3）, the loading plate（5）End and sliding block（3）It is fixedly connected, it is described
Loading plate（5）Lower horizontal be equipped with support plate（2）, the support plate（2）It is fixedly connected on box body（1）On inner wall, the branch
Fagging（2）Bottom both ends are equipped with T-bar（14）, the T-bar（14）One end run through support plate（2）And end connects jointly
It is connected on loading plate（5）Bottom, the T-bar（14）It is upper to be arranged respectively there are two rubber spring（13）, two rubber bullets
Spring（13）It is located at support plate（2）Top and bottom, in the loading plate（5）Above and below be respectively equipped with pressurizing unit
And lifting apparatus, the box body（1）Bottom be equipped with chlorination equipment.
2. a kind of immunocyte amplification in vitro kit according to claim 1, which is characterized in that the lifting apparatus packet
Include supporting plate（19）, the supporting plate（19）Both ends be arranged with sliding equipment, the sliding equipment includes two pieces of limiting plates（15）,
Two pieces of limiting plates（15）It is connected horizontally on box body（1）Inner wall on, two pieces of limiting plates（15）Between equidistant company
It is connected to more slide bars（23）, the supporting plate（19）With multiple slide bars（23）Between be slidably connected, the supporting plate（19）Up and down two
The slide bar at end（23）On be arranged with second spring（24）, in the supporting plate（19）Upper surface be equipped with the second foam-rubber cushion
（26）.
3. a kind of immunocyte amplification in vitro kit according to claim 1, which is characterized in that the pressurizing unit packet
Include U-shaped pull rod（10）, the U-shaped pull rod（10）Both ends run through box cover（6）And end is connected with pressing plate jointly（7）, the U
Type pull rod（10）Both ends be arranged with the first spring（11）, first spring（11）Both ends be connected to box cover（6）
Bottom end and pressing plate（7）Upper surface, in the pressing plate（7）Bottom is equipped with the first foam-rubber cushion（9）.
4. a kind of immunocyte amplification in vitro kit according to claim 1, which is characterized in that the chlorination equipment packet
Include the disinfection box not bound（20）, the disinfection box（20）It is fixedly connected on box body（1）Bottom, and the disinfection box（20）With box
Body（1）Inside connection, the disinfection box（20）Inside is equipped with more sterilization pipes（21）.
5. a kind of immunocyte amplification in vitro kit according to claim 4, which is characterized in that the disinfection box（20）
Outside be equipped with charging interface（22）, the charging interface（22）With sterilization pipe（21）Between be connected to by conducting wire.
6. a kind of immunocyte amplification in vitro kit according to claim 1, which is characterized in that the box body（1）Bottom
Portion quadrangle is installed with foot pad（16）.
7. a kind of immunocyte amplification in vitro kit according to claim 3, which is characterized in that the box cover（6）Top
The U-shaped pull rod in portion（10）Both ends be connected through a screw thread adjusting nut（8）.
8. a kind of immunocyte amplification in vitro kit according to claim 1, which is characterized in that the test tube jack
（12）Inside is mounted on rubber ring（25）.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810170624.6A CN108300662A (en) | 2018-03-01 | 2018-03-01 | A kind of immunocyte amplification in vitro kit |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810170624.6A CN108300662A (en) | 2018-03-01 | 2018-03-01 | A kind of immunocyte amplification in vitro kit |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108300662A true CN108300662A (en) | 2018-07-20 |
Family
ID=62849224
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810170624.6A Withdrawn CN108300662A (en) | 2018-03-01 | 2018-03-01 | A kind of immunocyte amplification in vitro kit |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108300662A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113335723A (en) * | 2021-05-22 | 2021-09-03 | 袁二红 | Fruit transport case |
| CN113399012A (en) * | 2021-06-30 | 2021-09-17 | 东莞现代产品整理服务有限公司 | Food microorganism detection sampling method and sampling box thereof |
-
2018
- 2018-03-01 CN CN201810170624.6A patent/CN108300662A/en not_active Withdrawn
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113335723A (en) * | 2021-05-22 | 2021-09-03 | 袁二红 | Fruit transport case |
| CN113335723B (en) * | 2021-05-22 | 2024-05-03 | 昌嘉控股集团有限公司 | Fruit transport case |
| CN113399012A (en) * | 2021-06-30 | 2021-09-17 | 东莞现代产品整理服务有限公司 | Food microorganism detection sampling method and sampling box thereof |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20180720 |