CN108294774A

CN108294774A - A kind of PET correct scans method, apparatus and equipment

Info

Publication number: CN108294774A
Application number: CN201810007740.6A
Authority: CN
Inventors: 付长青; 孙智鹏
Original assignee: Neusoft Medical Systems Co Ltd
Current assignee: Neusoft Medical Systems Co Ltd
Priority date: 2018-01-04
Filing date: 2018-01-04
Publication date: 2018-07-20

Abstract

This application discloses a kind of PET correct scans methods, in the method, are corrected scanning to die body, obtain raw scanning data, the raw scanning data is the set for changing over time corresponding scan data with the activity of radioactive solution in the die body；It is transferred respectively from the raw scanning data and meets the scan datas of different PET alignment requirements and carry out different types of PET corrections, obtain PET scan correction factor corresponding with the different types of PET corrections.As it can be seen that this method injects primary emission solution only in die body, you can easy to operate, not error-prone, it is ensured that the accuracy of the PET scan correction factor obtained to obtain multiple PET scan correction factors.In addition, disclosed herein as well is a kind of PET correct scans device and equipment.

Description

A kind of PET correct scans method, apparatus and equipment

Technical field

This application involves data processing fields, and in particular to a kind of PET (Positron Emission Tomography, Positron emission tomography images) correct scan method, apparatus and equipment.

Background technology

PET device is a kind of advanced molecular imaging equipment.PET device can set PET after data acquisition The data of standby acquisition carry out image reconstruction, to obtain PET image.In practical applications, the number that PET device can be acquired first According to being corrected, image reconstruction is carried out using the data after correction, can achieve the purpose that export the preferable PET image of quality.

In the related art, the data that PET scan correction factor can be utilized to acquire PET device are corrected.PET is swept Retouching correction factor can be obtained by advance correct scan, PET scan correction factor can there are many.In the related art, Each PET scan correction factor in order to obtain needs to inject radioactive solution in die body, carries out a correct scan and obtains A kind of PET scan correction factor, then radioactive solution is injected in die body again, it carries out another secondary correct scan and obtains another kind PET scan correction factor, until obtaining each PET scan correction factor.But this kind of mode is cumbersome, can increase behaviour Make the operating time of personnel and be easy error, the situation of the PET scan correction factor inaccuracy obtained may be caused, influence PET The quality of image.

Invention content

In view of this, a kind of PET correct scans method, apparatus of the application offer and equipment, to solve PET in the prior art Correct scan technical problem complicated for operation.

To solve the above problems, technical solution provided by the embodiments of the present application is as follows：

In a first aspect, the embodiment of the present application provides a kind of positron emission tomography imaging PET correct scan methods, it is described Method includes：

Scanning is corrected to die body, obtains raw scanning data, includes radioactive solution in the die body, it is described original Scan data is that the set of corresponding scan data is changed over time with the activity of the radioactive solution；

Transfer the scan data progress different type for meeting different PET alignment requirements respectively from the raw scanning data PET corrections, obtain PET scan correction factor corresponding with the different types of PET corrections.

Optionally, described to transfer the scan data for meeting different PET alignment requirements respectively from the raw scanning data It carries out different types of PET corrections, obtains PET scan correction factor corresponding with the different types of PET corrections, wrap It includes：

It transfers to meet from the raw scanning data and meets the scan data of time adjustment requirement and carry out meeting time school Just, it obtains and meets time sweep correction factor；

The regular correction of scan data progress for meeting regular alignment requirements is transferred from the raw scanning data, is obtained Obtain regular scanning correction factor；

The scan data progress counting loss school for meeting counting loss alignment requirements is transferred from the raw scanning data Just, it obtains counting loss and scans correction factor；

The scan data progress active concentration school for meeting active concentration alignment requirements is transferred from the raw scanning data Just, it obtains active concentration and scans correction factor；

The scan data progress standard intake for meeting standard uptake value test request is transferred from the raw scanning data Value test, obtains standard uptake value test result.

Optionally,

It is described transferred from the raw scanning data meet meet time adjustment scanning require scan data accorded with Time adjustment is closed, acquisition meets the time adjustment scanning factor, including：

It determines during being corrected scanning to the die body, the activity of radioactive solution meets symbol in the die body Close the first time period of activity needed for time adjustment；From the scanning transferred in the raw scanning data in the first time period Data carry out meeting time adjustment, and acquisition meets the time adjustment scanning factor；

It is described that the regular school of scan data progress for meeting regular alignment requirements is transferred from the raw scanning data Just, normalization scanning correction factor is obtained, including：

It determines during being corrected scanning to the die body, the activity of radioactive solution meets just in the die body The second time period of activity needed for ruleization correction；From the scanning number transferred in the raw scanning data in the second time period According to regular correction is carried out, the regular correct scan factor is obtained；

It is described transferred from the raw scanning data meet counting loss alignment requirements scan data carry out count lose Correction is lost, counting loss is obtained and scans correction factor, including：

It determines during being corrected scanning to the die body, the activity of radioactive solution meets meter in the die body The third period of activity needed for number loss correction；From the scanning transferred in the raw scanning data in the third period Data carry out counting loss correction, obtain the counting loss correct scan factor；

It is described transferred from the raw scanning data meet active concentration alignment requirements scan data carry out activity it is dense Degree correction obtains active concentration and scans correction factor, including：

It determines during being corrected scanning to the die body, the activity of radioactive solution, which meets, in the die body lives 4th period of activity needed for property concentration correction；From the scanning transferred in the raw scanning data in the 4th period Data carry out active concentration correction, obtain the active concentration correct scan factor；

It is described that the scan data progress standard for meeting standard uptake value test request is transferred from the raw scanning data Uptake values are tested, and standard uptake value test result is obtained, including：

It determines during being corrected scanning to the die body, the activity of radioactive solution meets mark in the die body 5th period of activity needed for quasi- uptake values test；From transferring sweeping in the 5th period in the raw scanning data It retouches data and carries out standard uptake value test, obtain standard uptake value test result.

Optionally, described that scanning is corrected to die body, raw scanning data is obtained, including：

Multiple acquisition durations and the corresponding execution number of each acquisition duration are preset, scanning is corrected to die body, acquisition is every The scan data that a acquisition duration generates every time.

Optionally,

Described transferred from the raw scanning data meets when meeting the scan data of time adjustment requirement and being met Between correct, acquisition meet time sweep correction factor, including：

Meet from the activity for transferring radioactive solution in the die body in the scan data of acquisition and meets needed for time adjustment The scan data of activity, as the first raw scanning data；First raw scanning data is carried out meeting time adjustment, is obtained Time sweep correction factor must be met；

Meet from the activity for transferring radioactive solution in the die body in the scan data of acquisition living needed for normalization correction The scan data of degree, as the second raw scanning data；Regular correction is carried out to second raw scanning data, is obtained just Ruleization scan correction factor；

Meet needed for counting loss correction from the activity for transferring radioactive solution in the die body in the scan data of acquisition The scan data of activity, as third raw scanning data；Counting loss correction is carried out to the third raw scanning data, is obtained It obtains counting loss and scans correction factor；

Meet needed for active concentration correction from the activity for transferring radioactive solution in the die body in the scan data of acquisition The scan data of activity, as the 4th raw scanning data；Active concentration correction is carried out to the 4th raw scanning data, is obtained It obtains active concentration and scans correction factor；

Meet standard uptake value from the activity for transferring radioactive solution in the die body in the scan data of acquisition and tests institute The scan data for needing activity, as the 5th raw scanning data；Standard uptake value survey is carried out to the 5th raw scanning data Examination obtains standard uptake value test result.

Second aspect, the embodiment of the present application provides a kind of positron emission tomography imaging PET correct scan devices, described Device includes：

Obtaining unit obtains raw scanning data, includes radioactivity in the die body for being corrected scanning to die body Solution, the raw scanning data are the collection that corresponding scan data is changed over time with the activity of the radioactive solution It closes；

Unit is corrected, for transferring the scanning number for meeting different PET alignment requirements respectively from the raw scanning data According to different types of PET corrections are carried out, PET scan correction factor corresponding with the different types of PET corrections is obtained.

Optionally, the correction unit includes：

First correction subelement meets the scanning for meeting time adjustment requirement for being transferred from the raw scanning data Data carry out meeting time adjustment, and acquisition meets time sweep correction factor；

Second correction subelement, for transferring the scanning number for meeting regular alignment requirements from the raw scanning data According to regular correction is carried out, normalization scanning correction factor is obtained；

Third corrects subelement, for transferring the scanning for meeting counting loss alignment requirements from the raw scanning data Data carry out counting loss correction, obtain counting loss and scan correction factor；

4th correction subelement, for transferring the scanning for meeting active concentration alignment requirements from the raw scanning data Data carry out active concentration correction, obtain active concentration and scan correction factor；

5th correction subelement, meets sweeping for standard uptake value test request for being transferred from the raw scanning data It retouches data and carries out standard uptake value test, obtain standard uptake value test result.

Optionally,

The first correction subelement is specifically used for：

The second correction subelement is specifically used for：

The third correction subelement is specifically used for：

The 4th correction subelement is specifically used for：

The 5th correction subelement is specifically used for：

Optionally, the obtaining unit is specifically used for：

Optionally,

The first correction subelement is specifically used for：

The second correction subelement is specifically used for：

The third correction subelement is specifically used for：

The 4th correction subelement is specifically used for：

The 5th correction subelement is specifically used for：

The third aspect, the embodiment of the present application provide a kind of terminal device, and the terminal device includes：

Processor and memory；

The memory is transferred to the processor for storing program code, and by said program code；

The processor, for calling the positive electron described in the instruction execution claim 1-5 any one in memory Emission type tomography PET correct scan methods.

It can be seen that the embodiment of the present application has the advantages that：

The embodiment of the present application carries out primary correct scan incessantly to die body, obtains raw scanning data, described original Scan data is that the set of corresponding scan data is changed over time with the activity of radioactive solution in the die body；By from The scan data for meeting different PET alignment requirements is transferred in raw scanning data respectively, carries out different types of PET corrections, with Obtain PET scan correction factor corresponding with different types of PET corrections.The embodiment of the present application is injected once only in die body Radioactive solution, you can easy to operate, not error-prone, it is ensured that be obtained to obtain multiple PET scan correction factors The accuracy of PET scan correction factor.

Description of the drawings

Fig. 1 is a kind of Sample Scenario figure of PET correct scans method provided by the embodiments of the present application；

Fig. 2 is a kind of flow diagram of PET correct scans method provided by the embodiments of the present application；

Fig. 3 transfers raw scanning data result schematic diagram to be provided by the embodiments of the present application；

Fig. 4 is a kind of structure diagram of PET correct scans device provided by the embodiments of the present application.

Specific implementation mode

In order to make the above objects, features, and advantages of the present application more apparent, below in conjunction with the accompanying drawings and it is specific real Mode is applied to be described in further detail the embodiment of the present application.

In order to solve PET correct scans set forth above technical problem complicated for operation, the embodiment of the present application provides a kind of PET correct scan methods, this method inject primary emission solution only in die body, by once correct scan incessantly, Multiple PET scan correction factors can be obtained, it is easy to operate, not error-prone, it is ensured that the correction of the PET scan that is obtained because The accuracy of son.

For example, the method that the embodiment of the present application is provided can be applied to scene as shown in Figure 1.In the scene Under, user 101 can interact with the main controller 102 in Medical Devices, that is, user 101 can operate main controller 102, The operation and control Medical Devices that main controller 102 can respond user 101 execute corresponding action, such as can control Medical Devices It can be PET device to execute and be corrected actions, the Medical Devices such as scanning, acquisition raw scanning data to die body 103.

Specifically, first, user 101 can control PET device by main controller 102 and be corrected scanning to die body 103, And obtain raw scanning data.Wherein, may include radioactive solution in die body 103, the radioactive solution can be user 101 injection die bodys 103.Then, main controller 102 can respectively be transferred from the raw scanning data meets the different schools PET The scan data just required carries out different types of PET corrections, to obtain PET corresponding with different types of PET corrections Scan correction factor.

It should be noted that above application scene is merely for convenience of understanding the application and showing, the embodiment party of the application Formula is unrestricted in this regard.On the contrary, presently filed embodiment can be applied to applicable any scene.

Below in conjunction with the accompanying drawings, it is described in detail how the embodiment of the present application carries out PET correct scans.

Referring to Fig. 2, Fig. 2 is a kind of flow diagram of PET correct scans method provided by the embodiments of the present application, this method Including：

S201, it is corrected scanning to die body, obtains raw scanning data, include radioactive solution, institute in the die body It is the set that corresponding scan data is changed over time with the activity of the radioactive solution to state raw scanning data.

User can make PET device be corrected scanning to die body by main controller, to allow main controller to obtain PET device is corrected die body the raw scanning data after scanning, so that main controller carries out subsequently the raw scanning data Processing.

It should be noted that die body can be the model for simulating human body.Since the scanning to human body of PET device can be people Body brings radiation, and prolonged scanning may damage human body, therefore, in many cases, in particular for it is long when Between scanning, carry out situations such as PET device test, die body can be used to substitute human body and receive the scanning of PET device.

For example, during correcting acquisition PET scan correction factor by PET in the present embodiment, in this course, The activity comprising radioactive solution can be at any time in die body passage and constantly decay, and the speed to decay also can constantly become Slowly, in order to obtain the scan data for meeting different PET alignment requirements, need to make the activity of radioactive solution to decay from higher activity To very little activity, this just needs long time.And the raw scanning data is exactly opposite with the activity of the radioactive solution The set for the scan data answered, therefore, in order to obtain the corresponding scan data of activity different from the radioactive solution, It may need to carry out prolonged scanning correct scan to die body in S201.

It should be noted that the present embodiment is during entire correct scan, it is only necessary to inject primary emission into die body Property solution, you can with according to the radioactive solution activity variation obtain meet different PET alignment requirements scan data carry out Different types of PET corrections, to obtain multiple PET scan correction factors.

Referring in Fig. 1 103, the shape of the die body can be cylinder, and the material of the die body can be transparent organic The diameter of glass, the die body can be selected according to PET device or different effects, such as in the present embodiment, described The diameter of die body can be 200mm.In addition, needing the radioactive solution for including default activity, the radioactivity in the die body Solution for example can be fluorodeoxyglucose (F18-FDG).

The activity refers to the radioactive intensity of radioactive solution, during correct scan, the activity of radioactive solution It can change with the time of correct scan.

The default activity can be determined according to the difference of PET device.

S202, transferred respectively from the raw scanning data meet different PET alignment requirements scan data carry out not The PET of same type is corrected, and obtains PET scan correction factor corresponding with the different types of PET corrections.

Due to raw scanning data for only in die body inject primary emission solution be corrected scanning obtain with The activity of the radioactive solution changes over time the set of corresponding scan data, each in the raw scanning data Scan data may meet different PET alignment requirements, in this way, for each PET alignment requirements, the original scan number There may be the scan datas for meeting the PET alignment requirements in, then, main controller can will meet the PET alignment requirements Scan data takes out, for obtaining PET scan correction factor corresponding with the PET alignment requirements.

It should be noted that under normal circumstances, PET scan correction factor may include meet time sweep correction factor, Normalization scanning correction factor, counting loss scanning correction factor, active concentration scanning correction factor and standard uptake value test As a result etc..For each PET scan correction factor, which can be according to from raw scanning data The scan data for meeting PET alignment requirements transferred obtains, wherein PET alignment requirements and the PET scan correction factor phase It is corresponding.

In this case, in order to obtain different PET scan correction factors, S202 is specifically as follows：

It transfers to meet from the raw scanning data and meets the scan data of time adjustment requirement and carry out meeting time school Just, it obtains and meets time sweep correction factor；The scanning for meeting regular alignment requirements is transferred from the raw scanning data Data carry out regular correction, obtain normalization scanning correction factor；Satisfaction is transferred from the raw scanning data and is counted loses The scan data for losing alignment requirements carries out counting loss correction, obtains counting loss and scans correction factor；From the original scan The scan data progress active concentration correction for meeting active concentration alignment requirements is transferred in data, obtains active concentration scanning correction The factor；The scan data progress standard uptake value survey for meeting standard uptake value test request is transferred from the raw scanning data Examination obtains standard uptake value test result.

In the present embodiment, primary emission solution is injected only in die body, the main controller in Medical Devices can pass through The raw scanning data that once correct scan obtains incessantly, which respectively obtains, meets time sweep correction factor, normalization scanning Correction factor, counting loss scanning correction factor, active concentration scanning correction factor and standard uptake value test result.

It should be noted that the present embodiment is by the way that once correct scan obtains all raw scanning datas incessantly, The data volume of the raw scanning data is larger, and a large amount of space can be occupied during transimission and storage, therefore, in order to meet this Raw scanning data transimission and storage requirement, can by the raw scanning data using optical fiber be transferred to solid-state disk array into Row storage.

The embodiment of the present application is corrected scanning to die body, obtains raw scanning data, the raw scanning data be with The activity of radioactive solution changes over time the set of corresponding scan data in the die body；By from raw scanning data It is middle to transfer the scan data for meeting different PET alignment requirements respectively, different types of PET corrections are carried out, with acquisition and inhomogeneity The PET of type corrects corresponding PET scan correction factor.The embodiment of the present application injects primary emission solution only in die body, Multiple PET scan correction factors can be obtained, it is easy to operate, not error-prone, it is ensured that the correction of the PET scan that is obtained because The accuracy of son.In the present embodiment, under the premise of injecting primary emission solution only in die body, in correct scan process In, various ways may be used and obtain raw scanning data, wherein a kind of mode can be：Primary school is carried out to the die body Positive scanning, which continues one complete time, such as a correct scan continues 15 hours, and main controller can be adopted Collect the complete file in 15 hours.Another way can be：During carrying out a correct scan to die body, preset more A acquisition duration and the corresponding execution number of each acquisition duration acquire the scan data that each acquisition duration generates every time, to Multi collect is carried out to scan data.The purpose for the scan data that each acquisition duration of acquisition generates every time is that medical treatment is made to set Main controller in standby can obtain segmental file, and all segmental files can be used for preserving into raw scanning data, consequently facilitating Main controller in Medical Devices can transfer corresponding scan data according to different PET alignment requirements.For the Medical Devices For, what which carried out is single pass, does not need to repeat die body during being corrected scanning Such as the operation of injection radioactive solution, the acquisition of data is only taken multiple scan during correct scan to be segmented File.

For each PET scan correction factor, it is corresponding to it to obtain the PET scan correction factor PET correction, and the PET correction need radioactive solution activity meet the PET correction needed for activity when could carry out.But It is due to the growth with the correct scan time, the activity of radioactive solution can change in die body, under normal circumstances, radiation Property solution activity can reduce as the time increases, this may result in whithin a period of time, the activity of radioactive solution satisfaction Activity needed for PET corrections, exceeds this time, and the activity of radioactive solution cannot be satisfied activity needed for PET corrections, because This, can obtain the PET scan correction factor by the raw scanning data in this time.

In this case, the mode according to a correct scan obtains PET scan correction factor, can will obtain every Activity is as PET alignment requirements needed for the PET corrections that kind PET scan correction factor is carried out.

Therefore, it transfers and meets when meeting the scan data of time adjustment requirement and being met from the raw scanning data Between correct, acquisition meet time adjustment scanning the factor, may include：It determines in the process for being corrected scanning to the die body In, the activity of radioactive solution meets the first time period for meeting activity needed for time adjustment in the die body；From described original The scan data in the first time period is transferred in scan data to carry out meeting time adjustment, meets time adjustment to obtain Scan the factor.Wherein, the activity satisfaction of radioactive solution meets activity needed for time adjustment and can be wanted as time adjustment is met It asks.

The regular correction of scan data progress for meeting regular alignment requirements is transferred from the raw scanning data, is obtained Regular scanning correction factor is obtained, may include：It determines during being corrected scanning to the die body, in the die body The activity of radioactive solution meets the second time period of activity needed for normalization correction；Institute is transferred from the raw scanning data It states the scan data in second time period and carries out regular correction, to obtain the regular correct scan factor.Wherein, radioactivity The activity of solution, which meets activity needed for normalization correction, can be used as regular alignment requirements.

The scan data progress counting loss school for meeting counting loss alignment requirements is transferred from the raw scanning data Just, it obtains counting loss and scans correction factor, may include：It determines during being corrected scanning to the die body, institute The activity for stating radioactive solution in die body meets the third period of activity needed for counting loss correction；From the original scan number Transfer scan data in the third period in and carry out counting loss correction, to obtain counting loss correct scan because Son.Wherein, the activity of radioactive solution, which meets activity needed for counting loss correction, can be used as counting loss alignment requirements.

The scan data progress active concentration school for meeting active concentration alignment requirements is transferred from the raw scanning data Just, it obtains active concentration and scans correction factor, may include：It determines during being corrected scanning to the die body, institute The activity for stating radioactive solution in die body meets the 4th period of activity needed for active concentration correction；From the original scan number Transfer scan data in the 4th period in and carry out active concentration correction, to obtain active concentration correct scan because Son.Wherein, the activity of radioactive solution, which meets activity needed for active concentration correction, can be used as active concentration alignment requirements.

The scan data progress standard intake for meeting standard uptake value test request is transferred from the raw scanning data Value test, obtains standard uptake value test result, may include：It determines during being corrected scanning to the die body, The activity of radioactive solution meets the 5th period of activity needed for standard uptake value test in the die body；It original is swept from described It retouches the scan data transferred in data in the 5th period and carries out standard uptake value test, surveyed to obtain standard uptake value Test result.Wherein, the activity of radioactive solution, which meets activity needed for standard uptake value test, to be used as standard uptake value to test It is required that.

For example, the correct scan carried out to die body continues 15 hours, within this 15 hours, radioactive solution Activity can reduce as the time increases, and can be recorded to the activity of radioactive solution in scanning process, so that it is determined that The activity of radioactive solution meets the period of activity needed for different PET correction, to obtain corresponding PET scan correction because Son.In 15 hours, whether the activity based on radioactive solution meets activity needed for corresponding PET corrections, the different PET determined The correction corresponding period can be as shown in table 1.

The difference PET corrections corresponding period in table 1 15 hours

PET corrects type	Meet the period of PET alignment requirements
		Meet time adjustment	Timing node 1- timing nodes 2
Normalization correction	Timing node 3- timing nodes 4
		Counting loss corrects	Timing node 5- timing nodes 6
Active concentration corrects	Timing node 7- timing nodes 8
		Standard uptake value is tested	Timing node 9- timing nodes 10

From table 1 it follows that from timing node 1- timing nodes 2, the activity of radioactive solution decays to a certain numerical value, Numerical value satisfaction meets activity needed for time adjustment, then timing node 1- timing nodes 2 are used as first time period, using from original Scan data, which can obtain, in the first time period transferred in scan data meets the time adjustment scanning factor；It is similar, from when The activity of intermediate node 3- timing nodes 4, radioactive solution meets activity needed for normalization correction, then timing node 3- timing nodes 4 be used as second time period, using out of second time period that transferred in raw scanning data scan data can obtain normalization The correct scan factor；From timing node 5- timing nodes 6, the activity of radioactive solution meets activity needed for counting loss correction, Then timing node 5- timing nodes 6 are used as the third period, are swept using out of the third period that transferred in raw scanning data The counting loss correct scan factor can be obtained by retouching data；From timing node 7- timing nodes 8, the activity of radioactive solution meets Activity needed for active concentration correction, then timing node 7- timing nodes 8 are as the 4th period, using from raw scanning data Scan data can obtain the active concentration correct scan factor in the 4th period transferred；From timing node 9- timing nodes 10, the activity of radioactive solution meets activity needed for standard uptake value test, then timing node 9- timing nodes 10 are used as the 5th Period, using out of the 5th period that transferred in raw scanning data scan data can obtain standard uptake value test knot Fruit.

It should be noted that numerical value included in aforesaid time node, such as 1,2 ... 10, not to each time Time sequencing of node during entire correct scan is defined, and is only distinguished to each timing node.

During obtaining PET scan correction factor by a correct scan, for the ease of raw scanning data It transfers, raw scanning data can be segmented by multi collect scan data, make main controller in Medical Devices can be with Obtain segmental file.Wherein, a kind of can be swept according to correction in such a way that multi collect scan data obtains segmental file It retouches duration to be segmented, for example, being corrected scanning to die body, presets multiple acquisition durations and the corresponding execution of each acquisition duration Number acquires the scan data that each acquisition duration generates every time, until scanning total duration reaches default scanning total duration.It is another Kind can be divided according to collected scan data quantity in such a way that multi collect scan data obtains segmental file Section presets multiple acquisition durations and the corresponding execution number of each acquisition duration for example, being corrected scanning to die body, and acquisition is every The scan data that a acquisition duration generates every time, duration is acquired when one, and once collected scan data quantity is less than the acquisition When the corresponding predetermined threshold value of duration, the scan data acquisition of next acquisition duration is carried out.This two kinds are scanned by multi collect Data obtain concrete methods of realizing of the mode of segmental file during correct scan and will subsequently describe in detail.

It should be noted that during above two is in such a way that multi collect scan data obtains segmental file, due to putting The activity of penetrating property solution can reduce as the time increases, and with the growth of time, the variation of the activity of radioactive solution It can be gradually slack-off, in some instances it may even be possible to which the activity of radioactive solution will not change significantly within some time.Therefore, default more When a acquisition duration, the acquisition duration of the correct scan first carried out can shorter than after the acquisition duration of correct scan that carries out, with The passage of time, acquisition duration can be appropriately extended.

It should be noted that obtaining PET scan school by way of obtaining segmental file multi collect scan data When positive divisor, corresponding scan data is transferred when obtaining PET scan correction factor for convenience, it can be by the phase of multi collect Scan data with acquisition time saves as a file, and the scan data acquired every time can also be saved as to a file. In addition, when the activity using radioactive solution meets the required activity of PET corrections as PET alignment requirements, obtain for convenience The activity of radioactive solution, to transferring required scan data according to activity, can when each acquisition scans data are completed, The activity for recording Today radiation solution, required scan data is transferred according to activity to facilitate.

Above two will be introduced respectively below to sweep in correction in such a way that multi collect scan data obtains segmental file Concrete methods of realizing during retouching.

Can be acquisition every time in advance when using being segmented to multi collect scan data according to correct scan duration Setting acquisition duration, and determine the preset times being acquired with the acquisition duration, it is swept when completing the multiple of the preset times When retouching data acquisition, acquisition duration can be reset again, and determines that the acquisition duration reset with this is scanned number According to the preset times of acquisition, and so on.By taking table 2 as an example, table 2 shows that multi collect scan data obtains segmental file side Formula.From Table 2, it can be seen that in the present embodiment, first, setting is 15 minutes a length of when acquiring, preset times are 16 times, i.e., often Secondary acquisition continues 15 minutes, carries out 16 acquisitions within a length of 15 minutes when acquiring.Then, 25 minutes a length of when setting acquisition, in advance If number is 20 times, i.e., acquisition continues 25 minutes every time, carries out 20 acquisitions within a length of 25 minutes when acquiring.Finally, setting is adopted A length of 50 minutes when collection, preset times are 3 times, i.e., acquisition continues 50 minutes every time, adopt for 3 times within a length of 50 minutes when acquiring Collection, then terminate correct scan, obtains the raw scanning data that the multiple correct scan process generates.

2 multi collect scan data of table obtains segmental file mode

Preset times	Acquire duration
		16 times	15 minutes
20 times	25 minutes
		3 times	50 minutes

According to aforementioned discussion, in the present embodiment, the acquisition duration can be according to the activity of radioactive solution at any time Situation of change be configured, the preset times can be configured according to scanning total duration, under normal circumstances, at default time The total duration of multi collect process is carried out under the premise of number and acquisition duration should be equal or close to scanning total duration.For example, really Surely scanning total duration is 15 hours, and the preset times and acquisition duration are as shown in table 2, and the total duration which passes through is 16 × 15+20 × 25+3 × 50, the total duration which passes through was close to 15 hours.

In the present embodiment, the scan data collected every time can be saved as to a file, and acquired every time When scan data is completed, the activity of Today radiation solution is recorded, to conveniently transfer required scan data.

Can be that the acquisition of each scan data is set in advance when using being segmented according to collected scan data quantity Acquisition duration is set, after completing the scan data acquisition of the primary acquisition duration, judges this collected scan data quantity Whether it is less than predetermined threshold value, if this collected scan data quantity is less than predetermined threshold value, carries out other acquisition durations Scan data acquisition.

It should be noted that the predetermined threshold value is corresponding with the acquisition duration, i.e., different acquisition durations is corresponding pre- If threshold value can be different.So, if this collected scan data quantity is more than predetermined threshold value, continue the acquisition The scan data next time of duration acquires, if this collected scan data quantity is less than predetermined threshold value, carries out other The scan data acquisition of duration is acquired, and so on.

By taking table 3 as an example, table 3 shows that multi collect scan data obtains segmental file mode.From table 3 it is observed that In the present embodiment, first, 15 minutes a length of when setting acquisition, when completing primary acquisition, a length of 15 minutes scan datas are adopted After collection, judge whether collected scan data quantity is more than 1500/Kcps, if more than when then continuing to acquire next time A length of 15 minutes scan datas acquisition, and so on, a length of 15 minutes scan datas acquisition when having carried out a acquisition Afterwards, collected scan data quantity is not more than 1500/Kcps after the completion of a times scan data acquisition, then carries out next adopt A length of 25 minutes scan datas acquisition judges when completing primary acquisition after a length of 25 minutes scan datas acquisition when collection Whether collected scan data quantity is more than 50/Kcps, if more than a length of 25 minutes when then continuing to acquire next time Scan data acquires, and so on, when having carried out b acquisition after a length of 25 minutes scan datas acquisition, the b times scanning Collected scan data quantity is not more than 50/Kcps after the completion of data acquisition, then carries out when next acquisition a length of 50 minutes Scan data acquisition judge collected scanning number when completing primary acquisition after a length of 50 minutes scan datas acquisition Whether data bulk is more than 10/Kcps, if more than, then a length of 50 minutes scan datas acquisition when continuing to acquire next time, And so on, when having carried out c acquisition after a length of 50 minutes scan datas acquisition, the c times scan data acquisition is completed Collected scan data quantity is not more than 10/Kcps afterwards, then terminates all scan data acquisitions, obtain the original of the multi collect Beginning scan data.

3 multi collect scan data of table obtains segmental file mode

The instant counting of scanning at that time	Acquire duration	Scan total degree
			>1500/Kcps	15 minutes	A times
>50/Kcps	25 minutes	B times
			>10/Kcps	50 minutes	C times

In the present embodiment, the scan data that each scan data collects can save as to a file, and When each scan data acquisition is completed, the activity of Today radiation solution is recorded, to conveniently transfer required scan data.

After obtaining raw scanning data by way of obtaining segmental file multi collect scan data, for one kind PET is corrected, and the activity for the radioactive solution that the when of completing records is acquired according to each scan data, it may be determined which time scan data The activity of radioactive solution meets activity needed for the PET corrections when acquisition, and then determines and meet sweeping for activity needed for PET corrections Data are retouched, PET scan correction factor corresponding with PET corrections is obtained.

Therefore, in one implementation, it is described transfer satisfaction from the raw scanning data and meet time adjustment want The scan data asked carries out meeting time adjustment, and acquisition meets time sweep correction factor, including：From the scan data of acquisition The activity for transferring radioactive solution in the die body meets the scan data for meeting activity needed for time adjustment, original as first Scan data；First raw scanning data is carried out to meet time adjustment, acquisition meets time sweep correction factor.

It is described that the regular school of scan data progress for meeting regular alignment requirements is transferred from the raw scanning data Just, normalization scanning correction factor is obtained, including：From the work for transferring radioactive solution in the die body in the scan data of acquisition Degree meets the scan data of activity needed for normalization correction, as the second raw scanning data；To the second original scan number According to regular correction is carried out, normalization scanning correction factor is obtained.

It is described transferred from the raw scanning data meet counting loss alignment requirements scan data carry out count lose Correction is lost, counting loss is obtained and scans correction factor, including：From being transferred in the scan data of acquisition, radioactivity in the die body is molten The activity of liquid meets the scan data of activity needed for counting loss correction, as third raw scanning data；To third original Beginning scan data carries out counting loss correction, obtains counting loss and scans correction factor.

It is described transferred from the raw scanning data meet active concentration alignment requirements scan data carry out activity it is dense Degree correction obtains active concentration and scans correction factor, including：From being transferred in the scan data of acquisition, radioactivity in the die body is molten The activity of liquid meets the scan data of activity needed for active concentration correction, as the 4th raw scanning data；It is former to the described 4th Beginning scan data carries out active concentration correction, obtains active concentration and scans correction factor.

It is described that the scan data progress standard for meeting standard uptake value test request is transferred from the raw scanning data Uptake values are tested, and standard uptake value test result is obtained, including：From transferring radioactivity in the die body in the scan data of acquisition The activity of solution meets the scan data of activity needed for standard uptake value test, as the 5th raw scanning data；To described Five raw scanning datas carry out standard uptake value test, obtain standard uptake value test result.

It is understood that after obtaining each PET scan correction factor, obtained PET scan can be corrected because In some region of son write-in PET device, such as in the registration table of PET device, in practical application PET device, to utilize The data that the PET scan correction factor being written in the registration table of PET device acquires PET device are corrected.

It is introduced by taking table 2 as an example below and how to obtain PET scan correction factor.It is scanned according to the multi collect shown in table 2 After the mode of data acquisition segmental file obtains raw scanning data, if the activity satisfaction of radioactive solution meets time adjustment institute When needing activity, when corresponding scan data is acquisition when a length of 25 minutes the 4th, 5,6 collected raw scanning datas, then The the 4th, 5,6 collected scan data for transferring a length of 25 minutes when acquisition, as the first raw scanning data, to the first original The execution of beginning scan data meets time adjustment, then obtains meeting the time adjustment scanning factor, and be written into registration table；If radiation Property solution activity satisfaction when meeting activity needed for normalization correction, corresponding scan data be the of a length of 25 minutes when acquiring 2, it collected is swept for the 2nd, 3,4,5,6 time of a length of 25 minutes when 3,4,5,6 collected scan datas, then when transferring acquisition Data are retouched as the second raw scanning data, normalization correction is executed to the second raw scanning data, then obtains regular correction The factor is scanned, and is written into registration table；It is corresponding if the activity of radioactive solution meets activity needed for counting loss correction Scan data be each time collected scan data when, then transfer all scan datas as third raw scanning data, it is right Third raw scanning data executes counting loss correction, then obtains the counting loss correct scan factor, and be written into registration table； If the activity satisfaction of radioactive solution meets activity needed for active concentration correction, a length of 25 when corresponding scan data is acquisition When the 4th, the 5 collected scan data of minute, then a length of 25 minutes when acquisition the 4th, 5 collected scanning numbers are transferred According to as the 4th raw scanning data, active concentration correction is executed to the 4th raw scanning data, then obtains active concentration correction The factor is scanned, and is written into registration table；If the activity satisfaction of radioactive solution complies with standard activity needed for uptake values test, When corresponding scan data is acquisition when a length of 25 minutes the 5th, 6 collected scan datas, then transfer a length of when acquisition 25 minutes the 5th, 6 collected scan datas execute mark as the 5th raw scanning data to the 5th raw scanning data Quasi- uptake values test, then obtain standard uptake value test result, and be written into registration table.

Wherein, executing the transferred scan data result of each PET corrections can be as shown in Figure 3." √ " indicates quilt in Fig. 3 The scanning of acquisition duration corresponding to the scan data transferred.Above-mentioned scan data of transferring may be according to different equipment calls Correct scan number have difference, can arbitrarily transfer correct scan several times therein as needed.

After obtaining raw scanning data in such a way that the multi collect scan data shown in table 3 obtains segmental file, obtain The method for obtaining each PET scan correction factor may refer to the aforementioned method introduced by taking table 2 as an example, and details are not described herein again.

Based on a kind of PET correct scans method that previous embodiment provides, the embodiment of the present application also provides a kind of schools PET Positive scanning means shows that a kind of structure diagram of PET correct scans device, described device include referring to Fig. 4, Fig. 4：It obtains single Member 401 and correction unit 402.

The obtaining unit 401 obtains raw scanning data, is wrapped in the die body for being corrected scanning to die body Containing radioactive solution, the raw scanning data is to change over time corresponding scanning number with the activity of the radioactive solution According to set；

The correction unit 402 meets different PET alignment requirements for being transferred respectively from the raw scanning data Scan data carries out different types of PET corrections, obtains PET scan correction corresponding with the different types of PET corrections The factor.

Optionally, the correction unit 402 includes：

Optionally, the first correction subelement is specifically used for：

The second correction subelement is specifically used for：

The third correction subelement is specifically used for：

The 4th correction subelement is specifically used for：

The 5th correction subelement is specifically used for：

Optionally, the obtaining unit 401 is specifically used for：

Optionally, the first correction subelement is specifically used for：

The second correction subelement is specifically used for：

The third correction subelement is specifically used for：

The 4th correction subelement is specifically used for：

The 5th correction subelement is specifically used for：

Based on a kind of PET correct scans method and apparatus that previous embodiment provides, the embodiment of the present application also provides one Kind terminal device, the terminal device include：

Processor and memory；

The processor, for calling the schools PET described in any one of instruction execution previous embodiment in memory Positive scan method.

The embodiment of the present application is corrected scanning to die body, obtains raw scanning data, the raw scanning data be with The activity of radioactive solution changes over time the set of corresponding scan data in the die body；By from raw scanning data It is middle to transfer the scan data for meeting different PET alignment requirements respectively, different types of PET corrections are carried out, with acquisition and inhomogeneity The PET of type corrects corresponding PET scan correction factor.The embodiment of the present application injects primary emission solution only in die body, Multiple PET scan correction factors can be obtained, it is easy to operate, not error-prone, it is ensured that the correction of the PET scan that is obtained because The accuracy of son.

It should be noted that each embodiment is described by the way of progressive in this specification, each embodiment emphasis is said Bright is all difference from other examples, and just to refer each other for identical similar portion between each embodiment.For reality For applying system or device disclosed in example, since it is corresponded to the methods disclosed in the examples, so fairly simple, the phase of description Place is closed referring to method part illustration.

It should also be noted that, herein, relational terms such as first and second and the like are used merely to one Entity or operation are distinguished with another entity or operation, without necessarily requiring or implying between these entities or operation There are any actual relationship or orders.Moreover, the terms "include", "comprise" or its any other variant are intended to contain Lid non-exclusive inclusion, so that the process, method, article or equipment including a series of elements is not only wanted including those Element, but also include other elements that are not explicitly listed, or further include for this process, method, article or equipment Intrinsic element.In the absence of more restrictions, the element limited by sentence "including a ...", it is not excluded that There is also other identical elements in process, method, article or equipment including the element.

The step of method described in conjunction with the examples disclosed in this document or algorithm, can directly be held with hardware, processor The combination of capable software module or the two is implemented.Software module can be placed in random access memory (RAM), memory, read-only deposit Reservoir (ROM), electrically programmable ROM, electrically erasable ROM, register, hard disk, moveable magnetic disc, CD-ROM or technology In any other form of storage medium well known in field.

The foregoing description of the disclosed embodiments enables professional and technical personnel in the field to realize or use the application. Various modifications to these embodiments will be apparent to those skilled in the art, as defined herein General Principle can in other embodiments be realized in the case where not departing from spirit herein or range.Therefore, the application It is not intended to be limited to the embodiments shown herein, and is to fit to and the principles and novel features disclosed herein phase one The widest range caused.

Claims

1. a kind of positron emission tomography images PET correct scan methods, which is characterized in that the method includes：

Scanning is corrected to die body, obtains raw scanning data, includes radioactive solution, the original scan in the die body Data are that the set of corresponding scan data is changed over time with the activity of the radioactive solution；

Transferred respectively from the raw scanning data meet different PET alignment requirements scan data carry out it is different types of PET is corrected, and obtains PET scan correction factor corresponding with the different types of PET corrections.

2. according to the method described in claim 1, it is characterized in that, described transfer satisfaction respectively from the raw scanning data The scan data of different PET alignment requirements carries out different types of PET corrections, obtains and corrects phase with the different types of PET Corresponding PET scan correction factor, including：

It transfers to meet from the raw scanning data and meets the scan data of time adjustment requirement and carry out meeting time adjustment, obtain Time sweep correction factor must be met；

The regular correction of scan data progress for meeting regular alignment requirements is transferred from the raw scanning data, is obtained just Ruleization scan correction factor；

The scan data progress counting loss correction for meeting counting loss alignment requirements is transferred from the raw scanning data, is obtained It obtains counting loss and scans correction factor；

The scan data progress active concentration correction for meeting active concentration alignment requirements is transferred from the raw scanning data, is obtained It obtains active concentration and scans correction factor；

The scan data progress standard uptake value survey for meeting standard uptake value test request is transferred from the raw scanning data Examination obtains standard uptake value test result.

3. according to the method described in claim 2, it is characterized in that,

It is described transfer to meet from the raw scanning data meet scan data that time adjustment scanning requires when being met Between correct, acquisition meet time adjustment scanning the factor, including：

It determines during being corrected scanning to the die body, when the activity satisfaction of radioactive solution meets in the die body Between correct needed for activity first time period；From the scan data transferred in the raw scanning data in the first time period It carries out meeting time adjustment, acquisition meets the time adjustment scanning factor；

It is described that the regular correction of scan data progress for meeting regular alignment requirements is transferred from the raw scanning data, it obtains Regular scanning correction factor is obtained, including：

It determines during being corrected scanning to the die body, the activity of radioactive solution meets normalization in the die body The second time period of activity needed for correction；From the scan data transferred in the raw scanning data in the second time period into Row normalization correction, obtains the regular correct scan factor；

It is described that the scan data progress counting loss school for meeting counting loss alignment requirements is transferred from the raw scanning data Just, it obtains counting loss and scans correction factor, including：

It determines during being corrected scanning to the die body, the activity of radioactive solution meets to count and lose in the die body Lose the third period of activity needed for correction；From the scan data transferred in the raw scanning data in the third period Counting loss correction is carried out, the counting loss correct scan factor is obtained；

It is described that the scan data progress active concentration school for meeting active concentration alignment requirements is transferred from the raw scanning data Just, it obtains active concentration and scans correction factor, including：

It determines during being corrected scanning to the die body, it is dense to meet activity for the activity of radioactive solution in the die body 4th period of activity needed for degree correction；From the scan data transferred in the raw scanning data in the 4th period Active concentration correction is carried out, the active concentration correct scan factor is obtained；

It is described that the scan data progress standard intake for meeting standard uptake value test request is transferred from the raw scanning data Value test obtains standard uptake value test result, including：

It determines during being corrected scanning to the die body, the activity of radioactive solution meets standard and takes the photograph in the die body 5th period of activity needed for value test；From the scanning number transferred in the raw scanning data in the 5th period According to standard uptake value test is carried out, standard uptake value test result is obtained.

4. according to the method described in claim 2, it is characterized in that, described be corrected scanning, acquisition original scan to die body Data, including：

Multiple acquisition durations and the corresponding execution number of each acquisition duration are preset, scanning is corrected to die body, acquisition is each adopted The scan data that collection duration generates every time.

5. according to the method described in claim 4, it is characterized in that,

It is described transfer to meet from the raw scanning data meet the scan data of time adjustment requirement and carry out meeting time school Just, it obtains and meets time sweep correction factor, including：

Meet from the activity for transferring radioactive solution in the die body in the scan data of acquisition and meets activity needed for time adjustment Scan data, as the first raw scanning data；First raw scanning data is carried out meeting time adjustment, is accorded with Close time sweep correction factor；

Meet activity needed for normalization correction from the activity for transferring radioactive solution in the die body in the scan data of acquisition Scan data, as the second raw scanning data；Regular correction is carried out to second raw scanning data, obtains normalization Scan correction factor；

Meet activity needed for counting loss correction from the activity for transferring radioactive solution in the die body in the scan data of acquisition Scan data, as third raw scanning data；Counting loss correction is carried out to the third raw scanning data, is counted Number loses scanning correction factor；

Meet activity needed for active concentration correction from the activity for transferring radioactive solution in the die body in the scan data of acquisition Scan data, as the 4th raw scanning data；Active concentration correction is carried out to the 4th raw scanning data, is lived Property concentration scan correction factor；

Meet from the activity for transferring radioactive solution in the die body in the scan data of acquisition living needed for standard uptake value test The scan data of degree, as the 5th raw scanning data；Standard uptake value test is carried out to the 5th raw scanning data, is obtained Obtain standard uptake value test result.

6. a kind of positron emission tomography images PET correct scan devices, which is characterized in that described device includes：

Obtaining unit obtains raw scanning data, includes that radioactivity is molten in the die body for being corrected scanning to die body Liquid, the raw scanning data are the set that corresponding scan data is changed over time with the activity of the radioactive solution；

Correct unit, for transferred respectively from the raw scanning data meet the scan datas of different PET alignment requirements into Row different types of PET correction obtains PET scan correction factor corresponding with the different types of PET corrections.

7. device according to claim 6, which is characterized in that the correction unit includes：

First correction subelement meets the scan data for meeting time adjustment requirement for being transferred from the raw scanning data It carries out meeting time adjustment, acquisition meets time sweep correction factor；

Second correction subelement, for transferred from the raw scanning data meet the scan datas of regular alignment requirements into Row normalization correction obtains normalization scanning correction factor；

Third corrects subelement, for transferring the scan data for meeting counting loss alignment requirements from the raw scanning data Counting loss correction is carried out, counting loss is obtained and scans correction factor；

4th correction subelement, for transferring the scan data for meeting active concentration alignment requirements from the raw scanning data Active concentration correction is carried out, active concentration is obtained and scans correction factor；

5th correction subelement, for transferring the scanning number for meeting standard uptake value test request from the raw scanning data According to standard uptake value test is carried out, standard uptake value test result is obtained.

8. device according to claim 7, which is characterized in that

The first correction subelement is specifically used for：

The second correction subelement is specifically used for：

The third correction subelement is specifically used for：

The 4th correction subelement is specifically used for：

The 5th correction subelement is specifically used for：

9. device according to claim 7, which is characterized in that the obtaining unit is specifically used for：

10. device according to claim 9, which is characterized in that

The first correction subelement is specifically used for：

The second correction subelement is specifically used for：

The third correction subelement is specifically used for：

The 4th correction subelement is specifically used for：

The 5th correction subelement is specifically used for：

11. a kind of terminal device, the terminal device include：

Processor and memory；

The processor, for calling the positron emission described in the instruction execution claim 1-5 any one in memory Type tomography PET correct scan methods.