CN108285933A - Using shrimp and crab shells as the ammonia sugar preparation method of raw material - Google Patents
Using shrimp and crab shells as the ammonia sugar preparation method of raw material Download PDFInfo
- Publication number
- CN108285933A CN108285933A CN201810225486.7A CN201810225486A CN108285933A CN 108285933 A CN108285933 A CN 108285933A CN 201810225486 A CN201810225486 A CN 201810225486A CN 108285933 A CN108285933 A CN 108285933A
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- China
- Prior art keywords
- shrimp
- chitin
- crab shells
- ammonia sugar
- raw material
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- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 title claims abstract description 116
- 241000238557 Decapoda Species 0.000 title claims abstract description 90
- 229910021529 ammonia Inorganic materials 0.000 title claims abstract description 58
- 238000002360 preparation method Methods 0.000 title claims abstract description 27
- 239000002994 raw material Substances 0.000 title claims abstract description 27
- 229920002101 Chitin Polymers 0.000 claims abstract description 102
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 45
- 238000001035 drying Methods 0.000 claims abstract description 18
- 238000000605 extraction Methods 0.000 claims abstract description 10
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 9
- 239000003607 modifier Substances 0.000 claims abstract description 7
- 238000000967 suction filtration Methods 0.000 claims abstract description 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 38
- 239000000243 solution Substances 0.000 claims description 37
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 27
- 150000003839 salts Chemical class 0.000 claims description 25
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 24
- 239000007788 liquid Substances 0.000 claims description 20
- 239000000463 material Substances 0.000 claims description 19
- 239000002245 particle Substances 0.000 claims description 16
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 14
- 230000001590 oxidative effect Effects 0.000 claims description 14
- 239000003153 chemical reaction reagent Substances 0.000 claims description 13
- 238000010298 pulverizing process Methods 0.000 claims description 12
- 238000006243 chemical reaction Methods 0.000 claims description 11
- 238000004321 preservation Methods 0.000 claims description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 9
- 108090000526 Papain Proteins 0.000 claims description 9
- 239000004365 Protease Substances 0.000 claims description 9
- -1 hydroxypropyl Chemical group 0.000 claims description 9
- 229940055729 papain Drugs 0.000 claims description 9
- 235000019834 papain Nutrition 0.000 claims description 9
- 239000007800 oxidant agent Substances 0.000 claims description 8
- 239000000725 suspension Substances 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 7
- 239000013049 sediment Substances 0.000 claims description 7
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 6
- 239000000047 product Substances 0.000 claims description 6
- 239000002253 acid Substances 0.000 claims description 5
- 239000013078 crystal Substances 0.000 claims description 5
- 238000004042 decolorization Methods 0.000 claims description 5
- 238000000502 dialysis Methods 0.000 claims description 5
- 239000012153 distilled water Substances 0.000 claims description 5
- 239000000706 filtrate Substances 0.000 claims description 5
- 238000001914 filtration Methods 0.000 claims description 5
- 239000012535 impurity Substances 0.000 claims description 5
- 238000002347 injection Methods 0.000 claims description 5
- 239000007924 injection Substances 0.000 claims description 5
- 239000000843 powder Substances 0.000 claims description 5
- 239000002244 precipitate Substances 0.000 claims description 5
- 238000010992 reflux Methods 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- 238000007654 immersion Methods 0.000 claims description 4
- 239000004115 Sodium Silicate Substances 0.000 claims description 3
- 239000008367 deionised water Substances 0.000 claims description 3
- 229910021641 deionized water Inorganic materials 0.000 claims description 3
- 229960002163 hydrogen peroxide Drugs 0.000 claims description 3
- 229940099596 manganese sulfate Drugs 0.000 claims description 3
- 239000011702 manganese sulphate Substances 0.000 claims description 3
- 235000007079 manganese sulphate Nutrition 0.000 claims description 3
- SQQMAOCOWKFBNP-UHFFFAOYSA-L manganese(II) sulfate Chemical compound [Mn+2].[O-]S([O-])(=O)=O SQQMAOCOWKFBNP-UHFFFAOYSA-L 0.000 claims description 3
- 239000001301 oxygen Substances 0.000 claims description 3
- 229910052760 oxygen Inorganic materials 0.000 claims description 3
- 235000019795 sodium metasilicate Nutrition 0.000 claims description 3
- NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 claims description 3
- 229910052911 sodium silicate Inorganic materials 0.000 claims description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- 239000012752 auxiliary agent Substances 0.000 claims 2
- 230000007062 hydrolysis Effects 0.000 abstract description 3
- 238000006460 hydrolysis reaction Methods 0.000 abstract description 3
- 239000012467 final product Substances 0.000 abstract description 2
- 229920001282 polysaccharide Polymers 0.000 abstract description 2
- 239000005017 polysaccharide Substances 0.000 abstract description 2
- 150000004676 glycans Chemical class 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 description 6
- 238000007254 oxidation reaction Methods 0.000 description 6
- 210000001188 articular cartilage Anatomy 0.000 description 4
- 210000000988 bone and bone Anatomy 0.000 description 4
- 235000019441 ethanol Nutrition 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 3
- 206010003246 arthritis Diseases 0.000 description 3
- 210000000845 cartilage Anatomy 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000010420 shell particle Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- QQONPFPTGQHPMA-UHFFFAOYSA-N Propene Chemical group CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 2
- 238000005299 abrasion Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 230000001050 lubricating effect Effects 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 description 1
- 241000143060 Americamysis bahia Species 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 208000020084 Bone disease Diseases 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 150000004265 D-glucosamines Chemical class 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000012659 Joint disease Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 238000005903 acid hydrolysis reaction Methods 0.000 description 1
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 210000003321 cartilage cell Anatomy 0.000 description 1
- 230000008355 cartilage degradation Effects 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 235000019197 fats Nutrition 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 229960002442 glucosamine Drugs 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 239000002932 luster Substances 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 201000008482 osteoarthritis Diseases 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 235000015170 shellfish Nutrition 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 210000001258 synovial membrane Anatomy 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 239000002351 wastewater Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C13—SUGAR INDUSTRY
- C13K—SACCHARIDES OBTAINED FROM NATURAL SOURCES OR BY HYDROLYSIS OF NATURALLY OCCURRING DISACCHARIDES, OLIGOSACCHARIDES OR POLYSACCHARIDES
- C13K1/00—Glucose; Glucose-containing syrups
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
- C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
- C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
- A23J1/04—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from fish or other sea animals
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J3/00—Working-up of proteins for foodstuffs
- A23J3/30—Working-up of proteins for foodstuffs by hydrolysis
- A23J3/32—Working-up of proteins for foodstuffs by hydrolysis using chemical agents
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J3/00—Working-up of proteins for foodstuffs
- A23J3/30—Working-up of proteins for foodstuffs by hydrolysis
- A23J3/32—Working-up of proteins for foodstuffs by hydrolysis using chemical agents
- A23J3/34—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes
- A23J3/341—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of animal proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/18—Peptides; Protein hydrolysates
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0003—General processes for their isolation or fractionation, e.g. purification or extraction from biomass
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Biochemistry (AREA)
- Food Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Materials Engineering (AREA)
- Mycology (AREA)
- Zoology (AREA)
- Sustainable Development (AREA)
- General Chemical & Material Sciences (AREA)
- Marine Sciences & Fisheries (AREA)
- Emergency Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
The present invention provides a kind of using shrimp and crab shells as the ammonia sugar preparation method of raw material：Include the following steps：The chitin extraction from shrimp and crab shells；With chitin described in hydroxypropylation agent modifier, then the secondary hydrolyzate of chitin is obtained through secondary water solution；Ammonia sugar is obtained after the secondary hydrolyzate of the chitin is concentrated successively, suction filtration and drying.It is of the present invention using shrimp and crab shells as the ammonia sugar preparation method of raw material, the chitin extraction from shrimp and crab shells, to carry out secondary water solution after chitin described in hydroxypropylation agent modifier, increase the water solubility of chitin, to which the macromolecular polysaccharide enhanced in chitin is converted into the percent hydrolysis of ammonia sugar, and then improve the yield for preparing final product ammonia sugar during ammonia sugar using shrimp and crab shells as raw material.
Description
Technical field
The present invention relates to ammonia sugar preparing technical fields, and in particular to a kind of using shrimp and crab shells as the ammonia sugar preparation method of raw material.
Background technology
Glucosamine, full name are D- Glucosamines, and abbreviation ammonia sugar is before human body synthesis articular cartilage tissue is important
Body.The Bones and joints of human body have one layer of cartilage coating in junction, are the neonychiums in joint, and buffer protection function is played to joint.
If cartilage degradation, abrasion lose the protective effect to bone, osteoproliferation, osteoarthritis may result in.Ammonia sugar is joint
The core substance of cartilage is considered as so far by medical field, only substance that can prevent, treat bone and joint diseases at all：
Specific manifestation is as follows：
Supplement osteotrophy, strong bone, protection and repairing articular cartilage：Ammonia sugar can consumingly stimulate cartilage cell to synthesize people
Collagen in body and hyaluronic acid repair the articular cartilage being worn, and can generate new articular cartilage and synovial membrane；
Lubricating joint：Ammonia sugar can promote the secretion of joint fluid, to continuous lubricating joint cartilage surface, reduce abrasion, make pass
Save position nimbly and freely；
Arthritis is eliminated, arthralgia is slowed down：Ammonia sugar is " street cleaner " in articular cavity, can not only inhibit non-specific
The inflammatory reaction of the factor blocks the development of arthritis, releases pain, and can eliminate and be harmful to enzyme in articular cavity, improves and closes
The immunity of section and body.The raising that joint immunity is brought by supplementing ammonia sugar is the important prerequisite for eliminating arthritis.
Chitin is also chitin, is being collectively referred to as chitin and chitosan.It is widely present insects, aquatic shell-fish,
Without on spinal animal shell and on Mycophyta cell wall.It is unique existing cation in the nature found so far
Type edible fibers, American-European medical field are set to isolating protein, fat, carbohydrate, vitamin, mineral in early 1990s
" the 6th element of life " except matter.
Ammonia sugar can be obtained the study found that chitin is hydrolyzed in hydrochloric acid；It is existing in the prior art to utilize chitin system
The process of standby ammonia sugar, but due to the intrinsic chemical property of chitin itself, cause chitin degree of hydrolysis in hydrochloric acid not high, from
And greatly reduce the yield that ammonia sugar is prepared with chitin.
Invention content
In order to overcome the deficiencies of existing technologies, the present invention provide it is a kind of using shrimp and crab shells as the ammonia sugar preparation method of raw material, greatly
The big yield for improving ammonia sugar.
In order to reach above-mentioned purpose, the technical solution adopted by the present invention is as follows：
Using shrimp and crab shells as the ammonia sugar preparation method of raw material, include the following steps：
S1 chitin extractions from shrimp and crab shells；
Then S2 obtains the secondary hydrolyzate of chitin with chitin described in hydroxypropylation agent modifier through secondary water solution；
S3：Ammonia sugar is obtained after the secondary hydrolyzate of the chitin is concentrated successively, suction filtration and drying.
Preferably, the step S1 includes：
S1-1 crushes clean shrimp and crab shells, obtains shrimp and crab shells crushed material；
S1-2 is under ultrasonic wave, by the shrimp and crab shells crushed material successively through acidolysis removing inorganic salts and enzymolysis deproteination matter
Afterwards, catabolite is obtained；
The catabolite is carried out centrifugal treating by S1-3, and chitin is obtained after the drying precipitate centrifuged.
Preferably, described crush includes the high pressure crushing carried out successively and Ultrasonic Pulverization；
The high pressure crushes：Clean shrimp and crab shells are crushed into 1-5min in high pressure pulverizer at 1.6-2MPa；
The Ultrasonic Pulverization includes：By the shrimp and crab shells crushed through high pressure in distilled water under the ultrasonic wave of 350-400W into
Row Ultrasonic Pulverization 5-8min；
Preferably, the acidolysis includes：Under the ultrasonic wave of 150-200W power, by the shrimp and crab shells crushed material in quality
Filter liquor after 10-15min is impregnated in the citric acid solution that percentage concentration is 20-25%, and filter residue is washed with water to neutrality, is obtained
To the shrimp and crab shells particle of removing inorganic salts；Preferably, the mass ratio of the shrimp and crab shells crushed material and citric acid solution is：1:1.2-
1.5。
Preferably, the enzymolysis includes：Under the ultrasonic wave of 250-300W power, the shrimp and crab shells particle of inorganic salts will be removed
15-25min is digested in papain under 33-38 degrees Celsius, enzymolysis product is washed with water to neutrality, deproteination is obtained
The shrimp and crab shells particle of matter；The shrimp and crab shells particle of the removing inorganic salts and the mass ratio of papain are 90:1-2.
Preferably, in step S1-3, before the drying sediment, oxidative decoloration processing is carried out to it.
Preferably, the oxidative decoloration, which is handled, includes：The sediment is separated into suspension in deionized water, then
Oxidant is added into the suspension and oxidation promoter carries out the decolorization；The oxidant is that mass percentage concentration is
The hydrogenperoxide steam generator of 10-15%；The oxidation promoter includes that mass ratio is 0.5:The sodium metasilicate and manganese sulfate of 1-1.5；Press body
Product ratio：The suspension：Oxidant：Oxidation promoter=1:0.3-0.5：0.1-0.15；
Preferably, the method for modifying of the chitin includes：
a：After the chitin is crushed, under subzero 5-10 degrees Celsius, in the hydrogen-oxygen that mass percentage concentration is 10-15%
Change in sodium solution and impregnate 4-6h, then thaws under room temperature, be uniformly mixed to obtain chitin water soluble liquid；The sodium hydroxide is molten
The mass ratio of liquid and chitin is 1-2:3-5.
b：Hydroxypropylation reagent will be added in the chitin water soluble liquid, 15-20h is stirred at room temperature, obtains reaction solution, institute
State hydroxypropylation reagent include mass ratio be 1:The propylene oxide and bromopropyl alcohol of 1-2；The chitin water soluble liquid and hydroxypropylation
The volume ratio of reagent is 2:0.1-0.3；
c：The reaction solution is adjusted into pH to 6-7, it is dry after dialysis removal of impurities, obtain hydroxypropyl modified chitin.
Preferably, the secondary water solution includes：With mass percentage concentration it is the salt acidleach of 20-25% the chitin
Bubble is heated with stirring to 90~110 DEG C of heat preservation 1~10h of reflux, then adds activated carbon and is cooled to 65~80 DEG C of heat preservation 30-
50min；
The mass ratio of the chitin and the hydrochloric acid is 1:2-2.5；
The chitin and quality of activated carbon ratio are 80-100:1-5.
Preferably, the step S3 further comprises：
It is stirred in absolute ethyl alcohol injection addition activated carbon after the filtered filtrate concentration of the secondary hydrolyzate of the chitin
It mixes mixing, stands after 8-10h successively through filtering and drying, obtain clear crystal powder, as ammonia sugar；
The mass ratio of the secondary hydrolyzate of the chitin, activated carbon and absolute ethyl alcohol is 1:0.1-0.3:2-2.5.
With immediate prior art ratio, technical scheme of the present invention has following advantageous effect：
Using shrimp and crab shells as the ammonia sugar preparation method of raw material, the chitin extraction from shrimp and crab shells is tried the present invention with hydroxypropylation
Agent carries out secondary water solution after being modified the chitin, increases the water solubility of chitin, to enhance big point in chitin
Sub- polysaccharide conversion is the percent hydrolysis of ammonia sugar, and then improves the final product ammonia sugar during preparing ammonia sugar using shrimp and crab shells as raw material
Yield.
The present invention is using shrimp and crab shells as the ammonia sugar preparation method of raw material, from shrimp and crab shells during chitin extraction, first
Shrimp and crab shells are carried out high pressure crushing and Ultrasonic Pulverization successively, compared to the prior art, are on the one hand shortened shrimp and crab shells acid subsequently
Solution removing inorganic salts and the time for digesting deproteination matter, improve the production efficiency that ammonia sugar is prepared using shrimp and crab shells as raw material；It is another
Aspect is using shrimp and crab shells in the ammonia sugar preparation process of raw material, to reduce the dosage of acid hydrolysis solution, enzymolysis liquid and washings, from life
For production person's angle, production cost is reduced；For energy-saving and emission-reduction, the generation of technique waste water and waste liquid is reduced, environment is protected
Shield contributes.
The present invention aoxidizes it before the drying sediment by the ammonia sugar preparation method of raw material of shrimp and crab shells
On the other hand decolorization passes through on the one hand so that the indexs such as appearance luster of chitin of extraction meet the requirement of ammonia sugar preparation
The chitin of peroxidating decolorization is easier to be modified with hydroxypropylation reagent, to further improve the ammonia sugar of ammonia sugar
Yield.
Specific implementation mode
Technical scheme of the present invention is described further with reference to specific embodiment：
Embodiment 1
Using shrimp and crab shells as the ammonia sugar preparation method of raw material, include the following steps：
S1 chitin extractions from shrimp and crab shells；
S1-1 carries out high pressure crushing successively to clean shrimp and crab shells and Ultrasonic Pulverization crushes, and obtains shrimp and crab shells crushed material；
The high pressure crushes：Clean shrimp and crab shells are crushed into 1min in high pressure pulverizer at 1.6MPa；
The Ultrasonic Pulverization includes：The shrimp and crab shells crushed through high pressure are surpassed in distilled water under the ultrasonic wave of 350W
Sound crushes 5min；
S1-2 is under ultrasonic wave, by the shrimp and crab shells crushed material successively through acidolysis removing inorganic salts and enzymolysis deproteination matter
Afterwards, catabolite is obtained；
The acidolysis includes：Under the ultrasonic wave of 150W power, it is in mass percentage concentration by the shrimp and crab shells crushed material
Filter liquor after immersion 10min in 20% citric acid solution, and filter residue is washed with water to neutrality, obtain the shrimp of removing inorganic salts
Crab shell particle；Preferably, the mass ratio of the shrimp and crab shells crushed material and citric acid solution is：1:1.2；
The enzymolysis includes：Under the ultrasonic wave of 250W power, the shrimp and crab shells particle of inorganic salts will be removed in 33 degrees Celsius
Under 15min is digested in papain, enzymolysis product is washed with water to neutrality, the shrimp and crab shells particle of deproteination matter is obtained；
The shrimp and crab shells particle of the removing inorganic salts and the mass ratio of papain are 90:1；
The catabolite is carried out centrifugal treating by S1-3, and chitin is obtained after the drying precipitate centrifuged；
Then S2 obtains the secondary hydrolyzate of chitin with chitin described in hydroxypropylation agent modifier through secondary water solution；
The method of modifying of chitin described in S2-1 includes：
a：After the chitin is crushed, under subzero 10 degrees Celsius, the sodium hydroxide for being 10% in mass percentage concentration
4h is impregnated in solution, is then thawed under room temperature, and chitin water soluble liquid is uniformly mixed to obtain；The sodium hydroxide solution and first
The mass ratio of shell element is 1:3；
b：Hydroxypropylation reagent will be added in the chitin water soluble liquid, 15h is stirred at room temperature, obtains reaction solution, it is described
Hydroxypropylation reagent includes that mass ratio is 1:1 propylene oxide and bromopropyl alcohol；The chitin water soluble liquid and hydroxypropylation reagent
Volume ratio be 2:0.1；
c：The reaction solution is adjusted into pH to 6, it is dry after dialysis removal of impurities, obtain hydroxypropyl modified chitin；
Secondary water solution described in S2-2 includes：The salt acid soak for being 20% with mass percentage concentration the chitin, stirring
90 DEG C of heat preservation reflux 1h are heated to, activated carbon is then added and is cooled to 65 DEG C of heat preservation 30min；
The mass ratio of the chitin and the hydrochloric acid is 1:2；
The chitin and quality of activated carbon ratio are 80:1；
S3 is concentrated successively the secondary hydrolyzate of the chitin, filters and obtained after dry ammonia sugar, specifically includes:
It is stirred in absolute ethyl alcohol injection addition activated carbon after the filtered filtrate concentration of the secondary hydrolyzate of the chitin
It mixes mixing, stands after 8h successively through filtering and drying, obtain clear crystal powder, as ammonia sugar；
The mass ratio of the secondary hydrolyzate of the chitin, activated carbon and absolute ethyl alcohol is 1:0.1:2.
Embodiment 2
Using shrimp and crab shells as the ammonia sugar preparation method of raw material, include the following steps：
S1 chitin extractions from shrimp and crab shells；
Clean shrimp and crab shells are carried out high pressure crushing and Ultrasonic Pulverization by S1-1 successively, obtain shrimp and crab shells crushed material；
The high pressure crushes：Clean shrimp and crab shells are crushed into 5min in high pressure pulverizer at 2MPa；
The Ultrasonic Pulverization includes：The shrimp and crab shells crushed through high pressure are surpassed in distilled water under the ultrasonic wave of 400W
Sound crushes 8min；
S1-2 is under ultrasonic wave, by the shrimp and crab shells crushed material successively through acidolysis removing inorganic salts and enzymolysis deproteination matter
Afterwards, catabolite is obtained；
The acidolysis includes：Under the ultrasonic wave of 200W power, it is in mass percentage concentration by the shrimp and crab shells crushed material
Filter liquor after immersion 15min in 25% citric acid solution, and filter residue is washed with water to neutrality, obtain the shrimp of removing inorganic salts
Crab shell particle；The mass ratio of the shrimp and crab shells crushed material and citric acid solution is：1:1.5；
The enzymolysis includes：Under the ultrasonic wave of 300W power, the shrimp and crab shells particle of inorganic salts will be removed in 38 degrees Celsius
Under 25min is digested in papain, enzymolysis product is washed with water to neutrality, the shrimp and crab shells particle of deproteination matter is obtained；
The shrimp and crab shells particle of the removing inorganic salts and the mass ratio of papain are 90:2；
The catabolite is carried out centrifugal treating by S1-3, and chitin is obtained after the drying precipitate centrifuged；
Then S2 obtains the secondary hydrolyzate of chitin with chitin described in hydroxypropylation agent modifier through secondary water solution；
The method of modifying of chitin described in S2-1 includes：
a：After the chitin is crushed, under subzero 5 degrees Celsius, the sodium hydroxide for being 15% in mass percentage concentration is molten
6h is impregnated in liquid, is then thawed under room temperature, and chitin water soluble liquid is uniformly mixed to obtain；The sodium hydroxide solution and crust
The mass ratio of element is 2:3；
b：Hydroxypropylation reagent will be added in the chitin water soluble liquid, 20h is stirred at room temperature, obtains reaction solution, it is described
Hydroxypropylation reagent includes that mass ratio is 1:2 propylene oxide and bromopropyl alcohol；The chitin water soluble liquid and hydroxypropylation reagent
Volume ratio be 2:0.3；
c：The reaction solution is adjusted into pH to 7, it is dry after dialysis removal of impurities, obtain hydroxypropyl modified chitin；
Secondary water solution described in S2-2 includes：The salt acid soak for being 25% with mass percentage concentration the chitin, stirring
110 DEG C of heat preservation reflux 10h are heated to, activated carbon is then added and is cooled to 80 DEG C of heat preservation 50min；
The mass ratio of the chitin and the hydrochloric acid is 2-2.5；
The chitin and quality of activated carbon ratio are 100:5；
S3：Ammonia sugar is obtained after the secondary hydrolyzate of the chitin is concentrated successively, suction filtration and drying, is specifically included：
It is stirred in absolute ethyl alcohol injection addition activated carbon after the filtered filtrate concentration of the secondary hydrolyzate of the chitin
It mixes mixing, stands after 10h successively through filtering and drying, obtain clear crystal powder, as ammonia sugar；
The mass ratio of the secondary hydrolyzate of the chitin, activated carbon and absolute ethyl alcohol is 1:0.3:2.5.
Embodiment 3
Using shrimp and crab shells as the ammonia sugar preparation method of raw material, include the following steps：
S1 chitin extractions from shrimp and crab shells；
Clean shrimp and crab shells are carried out high pressure crushing and Ultrasonic Pulverization by S1-1 successively, obtain shrimp and crab shells crushed material；
The high pressure crushes：Clean shrimp and crab shells are crushed into 3min in high pressure pulverizer at 1.8MPa；
The Ultrasonic Pulverization includes：The shrimp and crab shells crushed through high pressure are surpassed in distilled water under the ultrasonic wave of 380W
Sound crushes 6min；
S1-2 is under ultrasonic wave, by the shrimp and crab shells crushed material successively through acidolysis removing inorganic salts and enzymolysis deproteination matter
Afterwards, catabolite is obtained；
The acidolysis includes：Under the ultrasonic wave of 175W power, it is in mass percentage concentration by the shrimp and crab shells crushed material
Filter liquor after immersion 13min in 22% citric acid solution, and filter residue is washed with water to neutrality, obtain the shrimp of removing inorganic salts
Crab shell particle；The mass ratio of the shrimp and crab shells crushed material and citric acid solution is：1:1.3；
The enzymolysis includes：Under the ultrasonic wave of 280 power, the shrimp and crab shells particle of inorganic salts will be removed under 35 degrees Celsius
20min is digested in papain, enzymolysis product is washed with water to neutrality, obtains the shrimp and crab shells particle of deproteination matter；Institute
The mass ratio of the shrimp and crab shells particle and papain of stating removing inorganic salts is 90:1.5；
The catabolite is carried out centrifugal treating by S1-3, and chitin is obtained after the drying precipitate centrifuged；
Then S2 obtains the secondary hydrolyzate of chitin with chitin described in hydroxypropylation agent modifier through secondary water solution；
The method of modifying of chitin described in S2-1 includes：
a：After the chitin is crushed, under subzero 7 degrees Celsius, the sodium hydroxide for being 12% in mass percentage concentration is molten
5h is impregnated in liquid, is then thawed under room temperature, and chitin water soluble liquid is uniformly mixed to obtain；The sodium hydroxide solution and crust
The mass ratio of element is 1.5:4；
b：Hydroxypropylation reagent will be added in the chitin water soluble liquid, 18h is stirred at room temperature, obtains reaction solution, it is described
Hydroxypropylation reagent includes that mass ratio is 1:1.5 propylene oxide and bromopropyl alcohol；The chitin water soluble liquid and hydroxypropylation examination
The volume ratio of agent is 2:0.2；
c：The reaction solution is adjusted into pH to 6.5, it is dry after dialysis removal of impurities, obtain hydroxypropyl modified chitin；
Secondary water solution described in S2-2 includes：The salt acid soak for being 23% with mass percentage concentration the chitin, stirring
100 DEG C of heat preservation reflux 5h are heated to, activated carbon is then added and is cooled to 75 DEG C of heat preservation 40min；
The mass ratio of the chitin and the hydrochloric acid is 1.5-2.5；
The chitin and quality of activated carbon ratio are 90:3；
S3：Ammonia sugar is obtained after the secondary hydrolyzate of the chitin is concentrated successively, suction filtration and drying, is specifically included：
It is stirred in absolute ethyl alcohol injection addition activated carbon after the filtered filtrate concentration of the secondary hydrolyzate of the chitin
It mixes mixing, stands after 9h successively through filtering and drying, obtain clear crystal powder, as ammonia sugar；
The mass ratio of the secondary hydrolyzate of the chitin, activated carbon and absolute ethyl alcohol is 1:0.2:2.3.
Embodiment 4
The present embodiment 4 is on the basis of embodiment 1-3, in step S1-3, before the drying sediment, to its into
The processing of row oxidative decoloration；
The oxidative decoloration is handled：The sediment is separated into suspension in deionized water, then to described
Oxidant is added in suspension and oxidation promoter carries out the decolorization；The oxidant is that mass percentage concentration is 10-
15% hydrogenperoxide steam generator；The oxidation promoter includes that mass ratio is 0.5:The sodium metasilicate and manganese sulfate of 1-1.5；By volume
Than：The suspension：Oxidant：Oxidation promoter=1:0.3-0.5：0.1-0.15.
The ammonia sugar preparation method of embodiment 1-4 and the comparison of existing ammonia sugar preparation method technological parameter are as follows:
Table 1：
The above embodiments are merely illustrative of the technical scheme of the present invention and are not intended to be limiting thereof, although with reference to above-described embodiment pair
The present invention is described in detail, those of ordinary skill in the art still can to the present invention specific implementation mode into
Row modification either equivalent replacement these without departing from any modification of spirit and scope of the invention or equivalent replacement, applying
Within the claims of the pending present invention.
Claims (10)
1. using shrimp and crab shells as the ammonia sugar preparation method of raw material, which is characterized in that include the following steps：
S1 chitin extractions from shrimp and crab shells；
Then S2 obtains the secondary hydrolyzate of chitin with chitin described in hydroxypropylation agent modifier through secondary water solution；
S3：Ammonia sugar is obtained after the secondary hydrolyzate of the chitin is concentrated successively, suction filtration and drying.
2. as described in claim 1 using shrimp and crab shells as the ammonia sugar preparation method of raw material, which is characterized in that the step S1 packets
It includes：
S1-1 crushes clean shrimp and crab shells, obtains shrimp and crab shells crushed material；
S1-2, by the shrimp and crab shells crushed material successively through acidolysis removing inorganic salts and enzymolysis deproteination matter, is obtained under ultrasonic wave
Catabolite；
The catabolite is carried out centrifugal treating by S1-3, and chitin is obtained after the drying precipitate centrifuged.
3. as claimed in claim 2 using shrimp and crab shells as the ammonia sugar preparation method of raw material, which is characterized in that it is described crushing include according to
The high pressure of secondary progress crushes and Ultrasonic Pulverization；
The high pressure crushes：Clean shrimp and crab shells are crushed into 1-5min in high pressure pulverizer at 1.6-2MPa；
The Ultrasonic Pulverization includes：The shrimp and crab shells crushed through high pressure are surpassed in distilled water under the ultrasonic wave of 350-400W
Sound crushes 5-8min.
4. as claimed in claim 2 using shrimp and crab shells as the ammonia sugar preparation method of raw material, which is characterized in that the acidolysis includes：
It is under the ultrasonic wave of 150-200W power, the shrimp and crab shells crushed material is molten in the citric acid that mass percentage concentration is 20-25%
Filter liquor after immersion 10-15min in liquid, and filter residue is washed till neutrality, obtain the shrimp and crab shells particle of removing inorganic salts.
5. as claimed in claim 4 using shrimp and crab shells as the ammonia sugar preparation method of raw material, which is characterized in that the enzymolysis includes：
Under the ultrasonic wave of 250-300W power, the shrimp and crab shells particles of inorganic salts will be removed under 33-38 degrees Celsius in papain
Middle enzymolysis 15-25min, neutrality is washed till by enzymolysis product, obtains the shrimp and crab shells particle of deproteination matter.
6. as claimed in claim 2 using shrimp and crab shells as the ammonia sugar preparation method of raw material, which is characterized in that in step S1-3,
Before the dry sediment, oxidative decoloration processing is carried out to it.
7. as claimed in claim 6 using shrimp and crab shells as the ammonia sugar preparation method of raw material, which is characterized in that at the oxidative decoloration
Reason includes：The sediment is separated into suspension in deionized water, oxidant and oxygen are then added into the suspension
Change auxiliary agent and carries out the decolorization；The oxidant is the hydrogenperoxide steam generator that mass percentage concentration is 10-15%；The oxygen
Change auxiliary agent includes that mass ratio is 0.5:The sodium metasilicate and manganese sulfate of 1-1.5.
8. as described in claim 2 or 6 using shrimp and crab shells as the ammonia sugar preparation method of raw material, which is characterized in that the chitin
Method of modifying include：
a：After the chitin is crushed, under subzero 5-10 degrees Celsius, in the sodium hydroxide that mass percentage concentration is 10-15%
4-6h is impregnated in solution, is then thawed under room temperature, and chitin water soluble liquid is uniformly mixed to obtain；
b：Hydroxypropylation reagent will be added in the chitin water soluble liquid, 15-20h is stirred at room temperature, obtains reaction solution；
c：The reaction solution is adjusted into pH to 6-7, it is dry after dialysis removal of impurities, obtain hydroxypropyl modified chitin.
9. as claimed in claim 8 using shrimp and crab shells as the ammonia sugar preparation method of raw material, which is characterized in that the secondary water unpacks
It includes：With mass percentage concentration it is the salt acid soak of 20-25% the chitin, is heated with stirring to 90~110 DEG C of heat preservation reflux 1
Then~10h adds activated carbon and is cooled to 65~80 DEG C of heat preservation 30-50min；
The mass ratio of the chitin and the hydrochloric acid is 1:2-2.5；
The chitin and quality of activated carbon ratio are 80-100:1-5.
10. as claimed in claim 9 using shrimp and crab shells as the ammonia sugar preparation method of raw material, which is characterized in that the step S3 into
One step includes：
It is stirred in absolute ethyl alcohol injection addition activated carbon after the filtered filtrate concentration of the secondary hydrolyzate of the chitin mixed
It is even, after standing 8-10h clear crystal powder, as ammonia sugar are obtained through filtering and drying successively.
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| CN201810225486.7A CN108285933B (en) | 2018-03-19 | 2018-03-19 | Method for preparing glucosamine from shrimp and crab shells |
| PCT/CN2018/116358 WO2019179148A1 (en) | 2018-03-19 | 2018-11-20 | Method for preparing glucosamine by using shrimp and crab shells as raw materials |
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|---|---|---|---|---|
| CN109457060A (en) * | 2018-11-20 | 2019-03-12 | 扬州日兴生物科技股份有限公司 | It is a kind of using shrimp and crab shells as the ammonia sugar preparation method of raw material |
| WO2019179148A1 (en) * | 2018-03-19 | 2019-09-26 | 扬州日兴生物科技股份有限公司 | Method for preparing glucosamine by using shrimp and crab shells as raw materials |
| CN111227026A (en) * | 2020-03-09 | 2020-06-05 | 中国海洋大学 | Method for preparing meat preservative film by using shrimp and crab shells |
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| CN112521426B (en) * | 2020-12-15 | 2022-01-11 | 山东润德生物科技有限公司 | Method for preparing glucosamine |
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| CN1858069A (en) * | 2006-05-30 | 2006-11-08 | 武汉大学 | Method for preparing Chitosan double quaternary ammonium salt |
| CN101288482A (en) * | 2008-05-23 | 2008-10-22 | 海南京润珍珠生物技术股份有限公司 | Pearl safflower capsules |
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| CN101225126B (en) * | 2008-02-14 | 2011-08-31 | 中国林业科学研究院资源昆虫研究所 | Method for extracting chitin and chitin thereof |
| CN104480228A (en) * | 2014-11-25 | 2015-04-01 | 荣成宏业海洋科技有限公司 | Method for preparing glucosamine by utilizing shrimp and crab shells |
| CN108285933B (en) * | 2018-03-19 | 2021-06-04 | 扬州日兴生物科技股份有限公司 | Method for preparing glucosamine from shrimp and crab shells |
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| CN1858069A (en) * | 2006-05-30 | 2006-11-08 | 武汉大学 | Method for preparing Chitosan double quaternary ammonium salt |
| CN101288482A (en) * | 2008-05-23 | 2008-10-22 | 海南京润珍珠生物技术股份有限公司 | Pearl safflower capsules |
| KR20140123301A (en) * | 2013-04-12 | 2014-10-22 | 조선대학교산학협력단 | Preparation method of saccharification products from cellulose or alginate by radical initiator and metal catalyzed reactions |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019179148A1 (en) * | 2018-03-19 | 2019-09-26 | 扬州日兴生物科技股份有限公司 | Method for preparing glucosamine by using shrimp and crab shells as raw materials |
| CN109457060A (en) * | 2018-11-20 | 2019-03-12 | 扬州日兴生物科技股份有限公司 | It is a kind of using shrimp and crab shells as the ammonia sugar preparation method of raw material |
| CN111227026A (en) * | 2020-03-09 | 2020-06-05 | 中国海洋大学 | Method for preparing meat preservative film by using shrimp and crab shells |
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