CN108261190A - Continuous BP measurement method, apparatus and equipment - Google Patents

Continuous BP measurement method, apparatus and equipment Download PDF

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CN108261190A
CN108261190A CN201611270183.4A CN201611270183A CN108261190A CN 108261190 A CN108261190 A CN 108261190A CN 201611270183 A CN201611270183 A CN 201611270183A CN 108261190 A CN108261190 A CN 108261190A
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wave
pulse
pulse wave
heart beat
beat cycle
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CN108261190B (en
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林宛华
李光林
林闯
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Shenzhen Institute of Advanced Technology of CAS
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Shenzhen Institute of Advanced Technology of CAS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/021—Measuring pressure in heart or blood vessels
    • A61B5/02108—Measuring pressure in heart or blood vessels from analysis of pulse wave characteristics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/021—Measuring pressure in heart or blood vessels
    • A61B5/02108—Measuring pressure in heart or blood vessels from analysis of pulse wave characteristics
    • A61B5/02116—Measuring pressure in heart or blood vessels from analysis of pulse wave characteristics of pulse wave amplitude
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6802—Sensor mounted on worn items
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Physiology (AREA)
  • Vascular Medicine (AREA)
  • Artificial Intelligence (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Psychiatry (AREA)
  • Signal Processing (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)

Abstract

The invention discloses a kind of continuous BP measurement method, apparatus and equipment.The method includes：1) link is calibrated：The pulse wave of measurand is sampled to obtain sample pulse characteristics parameter, and obtain the reference pressure value of measurand, pulse characteristics parameter is the characteristic parameter of pulse wave of the measurand in heart beat cycle, pulse characteristics parameter includes the first pulse characteristics parameter, and the first pulse characteristics parameter includes：The slope of ascending branch, the amplitude difference of ascending branch, the area coverage of ascending branch, the slope of decent, the amplitude difference of decent and decent at least one of area coverage；According to the figure parameters that blood pressure appraising model is calculated with reference to pressure value and sample pulse characteristics parameter；2) measurement links：The pulse wave of measurand measure in real time so as to obtain real-time pulse characteristics parameter；Figure parameters and real-time pulse characteristics parameter are inputted into blood pressure appraising model, so as to estimate the continuous blood pressure value of often fighting in real time of measurand.

Description

Continuous BP measurement method, apparatus and equipment
Technical field
The present invention relates to medical instruments field more particularly to a kind of continuous BP measurement method, apparatus and equipment.
Background technology
The blood of people, which is transported to each position of whole body, needs certain pressure, this pressure is exactly blood pressure.Blood pressure is that blood exists During intravascular flow, the pressure of vasoactive wall, it is the power that blood is pushed to flow in the blood vessels.Ventricular contraction, blood Flow into artery from ventricle, blood is to the pressure highest of artery at this time, referred to as systolic pressure (systolic blood pressure, SBP).Ventricular diastole, arteries elastical retraction, blood still slowly continues flow forward, but blood pressure declines, when blood pressure drops to most During low value, pressure at this time is known as diastolic pressure (diastolic blood pressure, DBP).Blood pressure is health state An important indicator, in various medical treatment situations, be required in real time measuring the blood pressure of patient.But traditional water The precision of silver-colored blood pressure measuring amount is higher, unsuitable real-time continuous measurement blood pressure, and existing real-time continuous measurement blood pressure side The measurement accuracy of method is not high.
Invention content
Technical problem to be solved of the embodiment of the present invention is, provide a kind of continuous BP measurement method, apparatus and Equipment effectively can simply realize the real-time measurement to continuous blood pressure of often fighting.
First aspect present invention provides a kind of continuous BP measurement method, includes the following steps：
Continuous BP measurement equipment samples the pulse wave of measurand to obtain sample pulse characteristics parameter, and obtains The reference pressure value of the measurand is taken, wherein, the pulse characteristics parameter is the measurand in heart beat cycle The characteristic parameter of pulse wave, the pulse characteristics parameter include the first pulse characteristics parameter, the first pulse characteristics parameter packet It includes：The slope of ascending branch, the amplitude difference of ascending branch, the area coverage of ascending branch, the slope of decent, decent amplitude difference with And at least one of area coverage of decent, the reference pressure value of the measurand is by accurate blood pressure measuring instrument Measure what is obtained；
Blood is calculated with reference to pressure value and the sample pulse characteristics parameter according to described in continuous BP measurement equipment Press the figure parameters of appraising model；
Continuous BP measurement equipment to the pulse wave of the measurand measure in real time special so as to obtain real-time pulse Levy parameter；
The figure parameters and the real-time pulse characteristics parameter are inputted the blood pressure and estimated by continuous BP measurement equipment Model is calculated, so as to estimate the continuous blood pressure value of often fighting in real time of the measurand.
Wherein, the slope of the ascending branchWherein, IPMain wave for pulse wave in heart beat cycle The amplitude of wave crest point, IV1For the amplitude of the starting trough point of pulse wave in heart beat cycle, TPMaster for pulse wave in heart beat cycle The corresponding moment value of wave wave crest point, TV1The corresponding moment value of starting trough point for pulse wave in heart beat cycle；
The amplitude difference PPG_AID=of the ascending branch | IP-IV1|, wherein, IPMain wave wave for pulse wave in heart beat cycle The amplitude of peak dot, IV1Amplitude for the starting trough point of pulse wave in heart beat cycle；
The area coverage of the ascending branchWherein, P is the master of pulse wave in heart beat cycle Wave wave crest point, V1For the starting trough point of pulse wave in heart beat cycle, i is free variable, IiFor the amplitude of i points,To terminate wave Valley point V1Amplitude；
The slope of the decentWherein, IPMain wave wave crest point for pulse wave in heart beat cycle Amplitude, IV2For the amplitude of the terminal trough point of pulse wave in heart beat cycle, TPMain wave wave crest for pulse wave in heart beat cycle The corresponding moment value of point, TV2The corresponding moment value of terminal trough point for pulse wave in heart beat cycle；
The amplitude difference PPG_DID=of the decent | IP-IV2|, wherein, IPMain wave wave for pulse wave in heart beat cycle The amplitude of peak dot, IV2Amplitude for the terminal trough point of pulse wave in heart beat cycle；
The covering surface of the decent andWherein, P is the master of pulse wave in heart beat cycle Wave wave crest point, V2For the end trough point of pulse wave in heart beat cycle, i is free variable, IiFor the amplitude of i points,To terminate Trough point V2Amplitude.
Wherein, the blood pressure appraising model includes linear regression model (LRM), nonlinear regression model (NLRM) or machine learning model (such as multilayer perceptron neural network, random forest, support vector machines, deep learning).
Wherein, the linear regression model (LRM) is y=Ax+B, wherein, A and B are the figure parameters of linear regression model (LRM), x For pulse characteristics parameter, y is pressure value.
Wherein, the pulse characteristics parameter further includes the second pulse wave characteristic parameters, second pulse wave characteristic parameters Including：Pulse wave transmission time, pulse wave wave crest and trough Amplitude Ratio, main wave height, dicrotic notch height, dicrotic notch are relatively high Degree, dicrotic pulse wave height, dicrotic wave relative altitude, the minimum of pulse wave data waveform, the pulsation period, diastole it is lasting when Between, the time ratios of systole phase and diastole, area ratio, the pulse wave data of main wave rise time, systole phase and diastole At least one of rate of climb of the area of waveform, the slope of pulse wave wave crest to dicrotic notch and pulse wave.
Wherein, the linear regression model (LRM) is c=k1a+k2b+k3, wherein, k1、k2And k3It is that linear regression model (LRM) is Number parameter, a are the first pulse characteristics parameter, and b is the second pulse characteristics parameter, and c is pressure value.
Second aspect of the present invention provides a kind of continuous blood pressure measurer, including acquisition module, computing module, actual measurement mould Block and estimation block,
The acquisition module is used to sample the pulse wave of measurand to obtain sample pulse characteristics parameter, and obtain The reference pressure value of the measurand is taken, wherein, the pulse characteristics parameter is the measurand in heart beat cycle The characteristic parameter of pulse wave, the pulse characteristics parameter include the first pulse characteristics parameter, the first pulse characteristics parameter packet It includes：The slope of ascending branch, the amplitude difference of ascending branch, the area coverage of ascending branch, the slope of decent, decent amplitude difference with And at least one of area coverage of decent, the reference pressure value of the measurand is by accurate blood pressure measuring instrument Measure what is obtained；
The computing module is used to that blood to be calculated with reference to pressure value and the sample pulse characteristics parameter according to described Press the figure parameters of appraising model；
The actual measurement module is used to that the pulse wave of the measurand measure in real time special so as to obtain real-time pulse Levy parameter；
The estimation block is used to estimate the figure parameters and the real-time pulse characteristics parameter input blood pressure Model is calculated, so as to estimate the continuous blood pressure value of often fighting in real time of the measurand.
Wherein, the slope of the ascending branchWherein, IPMain wave for pulse wave in heart beat cycle The amplitude of wave crest point, IV1For the amplitude of the starting trough point of pulse wave in heart beat cycle, TPMaster for pulse wave in heart beat cycle The corresponding moment value of wave wave crest point, TV1The corresponding moment value of starting trough point for pulse wave in heart beat cycle；
The amplitude difference PPG_AID=of the ascending branch | IP-IV1|, wherein, IPMain wave wave for pulse wave in heart beat cycle The amplitude of peak dot, IV1Amplitude for the starting trough point of pulse wave in heart beat cycle；
The area coverage of the ascending branchWherein, P is the master of pulse wave in heart beat cycle Wave wave crest point, V1For the starting trough point of pulse wave in heart beat cycle, i is free variable, IiFor the amplitude of i points,To terminate wave Valley point V1Amplitude；
The slope of the decentWherein, IPMain wave wave crest point for pulse wave in heart beat cycle Amplitude, IV2For the amplitude of the terminal trough point of pulse wave in heart beat cycle, TPMain wave wave crest for pulse wave in heart beat cycle The corresponding moment value of point, TV2The corresponding moment value of terminal trough point for pulse wave in heart beat cycle；
The amplitude difference PPG_DID=of the decent | IP-IV2|, wherein, IPMain wave wave for pulse wave in heart beat cycle The amplitude of peak dot, IV2Amplitude for the terminal trough point of pulse wave in heart beat cycle；
The area coverage of the decentWherein, P is the master of pulse wave in heart beat cycle Wave wave crest point, V2For the end trough point of pulse wave in heart beat cycle, i is free variable, IiFor the amplitude of i points,To terminate Trough point V2Amplitude.
Wherein, the blood pressure appraising model includes linear regression model (LRM), nonlinear regression model (NLRM) or machine learning mould Type.
Wherein, the linear regression model (LRM) is y=Ax+B, wherein, A and B are the figure parameters of linear regression model (LRM), x For pulse characteristics parameter, y is pressure value.
Wherein, the pulse characteristics parameter further includes the second pulse wave characteristic parameters, second pulse wave characteristic parameters Including：Pulse wave transmission time, pulse wave wave crest and trough Amplitude Ratio, main wave height, dicrotic notch height, dicrotic notch are relatively high Degree, dicrotic pulse wave height, dicrotic wave relative altitude, the minimum of pulse wave data waveform, the pulsation period, diastole it is lasting when Between, the time ratios of systole phase and diastole, area ratio, the pulse wave data of main wave rise time, systole phase and diastole At least one of rate of climb of the area of waveform, the slope of pulse wave wave crest to dicrotic notch and pulse wave.
Wherein, the linear regression model (LRM) is c=k1a+k2b+k3, wherein, k1、k2And k3It is that linear regression model (LRM) is Number parameter, a are the first pulse characteristics parameter, and b is the second pulse characteristics parameter, and c is pressure value.
Third aspect present invention provides a kind of continuous BP measurement equipment, and the equipment includes interface circuit, memory And processor, wherein, batch processing code is stored in memory, and processor is used to call the program generation stored in memory Code, for performing the following operations：
The pulse wave of measurand is sampled to obtain sample pulse characteristics parameter, and obtain the measurand With reference to pressure value, wherein, the pulse characteristics parameter is the characteristic parameter of pulse wave of the measurand in heart beat cycle, The pulse characteristics parameter includes the first pulse characteristics parameter, and the first pulse characteristics parameter includes：The slope of ascending branch, on The amplitude difference of ascending branch, the area coverage of ascending branch, the slope of decent, the amplitude difference of decent and decent area coverage At least one of, the reference pressure value of the measurand is obtained by accurate blood pressure measuring instrument measurement；
According to the coefficient that blood pressure appraising model is calculated with reference to pressure value and the sample pulse characteristics parameter Parameter；
The pulse wave of the measurand measure in real time so as to obtain real-time pulse characteristics parameter；
The figure parameters and the real-time pulse characteristics parameter are inputted into the blood pressure appraising model, so as to estimate State the continuous blood pressure value of often fighting in real time of measurand.
In above-described embodiment, the slope of ascending branch, the amplitude difference of ascending branch, the area coverage of ascending branch, decline are employed At least one pulse characteristics parameter calculates real-time survey in the slope of branch, the amplitude difference of decent and the area coverage of decent Amount measurand is often fought continuous blood pressure value in real time, and experimental data proves, using the slope of ascending branch, ascending branch amplitude difference, The area coverage of ascending branch, the slope of decent, the amplitude difference of decent and the area coverage of decent these pulse characteristics Parameter can detect pulse wave by photoelectric sensor and can be calculated, and continuous BP measurement can be realized without cuff, Electrocardio need not be measured, is easy to implement the comfortable wearable design of miniaturization, moreover, experimental data proves, using these pulses spy It is higher to calculate the precision of blood pressure to levy parameter, the use demand of various medical treatment situations can be met.
Description of the drawings
In order to illustrate more clearly about the embodiment of the present invention or technical scheme of the prior art, to embodiment or will show below There is attached drawing needed in technology description to be briefly described, it should be apparent that, the accompanying drawings in the following description is only this Some embodiments of invention, for those of ordinary skill in the art, without creative efforts, can be with Other attached drawings are obtained according to these attached drawings.
Fig. 1 is the schematic diagram of an embodiment of the pulse wave of heart beat cycle disclosed in the present invention is implemented；
Fig. 2 is a kind of flow chart of continuous BP measurement method disclosed in the present invention is implemented；
Fig. 3 is a kind of flow chart of the embodiment one of continuous BP measurement method disclosed in the present invention is implemented；
Fig. 4 is a kind of flow chart of the embodiment two of continuous BP measurement method disclosed in the present invention is implemented；
Fig. 5 is a kind of flow chart of the embodiment three of continuous BP measurement method disclosed in the present invention is implemented；
Fig. 6 a to d are the experimental result pictures obtained using a kind of continuous BP measurement method disclosed in present invention implementation；
Fig. 7 is a kind of structure diagram of continuous blood pressure measurer disclosed in the present invention is implemented；
Fig. 8 is a kind of structure diagram of continuous BP measurement equipment disclosed in the present invention is implemented.
Specific embodiment
Although it should be understood that may have been used term " first ", " second " etc. herein to describe each unit, But these units should not be limited by these terms.The use of these items is only for by a unit and another unit It distinguishes.For example, in the case of the range without departing substantially from exemplary embodiment, it is single that first unit can be referred to as second Member, and similarly second unit can be referred to as first unit.Term "and/or" used herein above include one of them or The arbitrary and all combination of more listed associated items.
Term used herein above is not intended to limit exemplary embodiment just for the sake of description specific embodiment.Unless Context clearly refers else, otherwise singulative used herein above "one", " one " also attempt to include plural number.Should also When understanding, term " comprising " and/or "comprising" used herein above provide stated feature, integer, step, operation, The presence of unit and/or component, and do not preclude the presence or addition of other one or more features, integer, step, operation, unit, Component and/or a combination thereof.
In multiple heart beat cycles, the pulse wave form of each heart beat cycle is substantially similar, so, below with one The pulse wave of heart beat cycle is introduced.As shown in Figure 1, when x-axis is the time, when y-axis is the range value of pulse wave, a heartbeat The pulse wave in period is as shown in Figure 1.Wherein, the A points in figure are main wave wave crest point, and B points is originate trough point, C point terminal troughs Point.It is known as ascending branch from B points to A points, is known as decent from A points to C points.Pulse wave shown in Fig. 1 is intended only as one kind and shows Example rather than specific restriction, for different human bodies, the shape of pulse wave is usually different, still, can all have main wave Wave crest point, starting trough point and feature as terminal trough point.
Pulse characteristics parameter is parameter the characteristics of can reflecting pulse wave, for example, the width of the main wave wave crest point of pulse wave Value is a pulse characteristics parameter of pulse wave, it can reflect the maximum value of pulse wave；The width of the starting trough point of pulse wave Value is a pulse characteristics parameter of pulse wave, it can reflect minimum value of the pulse wave in ascending branch, the terminal wave of pulse wave The amplitude of valley point is a pulse characteristics parameter of pulse wave, it can reflect pulse wave in minimum value of decent etc..Arteries and veins Fight characteristic parameter quantity to be multiple, in embodiments of the present invention, pulse characteristics parameter is artificially divided into the first pulse spy Levy parameter and the second pulse characteristics parameter.Wherein, the first pulse characteristics parameter is new discovery and the pulse applied in the present invention Characteristic parameter, the second pulse characteristics parameter are more common pulse characteristics parameters.First pulse characteristics parameter is the oblique of ascending branch Rate, the amplitude difference of ascending branch, the area coverage of ascending branch, the slope of decent, the amplitude difference of decent and decent cover One or more combination in capping product.Second pulse characteristics parameter is pulse wave transmission time, pulse wave wave crest and wave Paddy Amplitude Ratio, main wave height, dicrotic notch height, dicrotic notch relative altitude, dicrotic pulse wave height, dicrotic wave relative altitude, pulse wave Minimum, pulsation period, the duration of diastole, systole phase and the time ratios of diastole of data waveform, main wave rise Time, the area ratio in systole phase and diastole, the area of pulse wave data waveform, pulse wave wave crest to dicrotic notch slope with And the combination of one or more in rate of climb of pulse wave etc..It is understood that since length is limited, herein only Part the second pulse characteristics parameter is listed, also more second pulse characteristics parameters just do not list one by one herein.
Since the first pulse characteristics parameter is to find in the present invention and apply first, so, below in conjunction with Fig. 1 pairs Six the first pulse characteristics parameters (slope of ascending branch, the amplitude difference of ascending branch, the area coverage of ascending branch, decent it is oblique The area coverage of rate, the amplitude difference of decent and decent) emphasis is introduced, and in the prior art existing second Pulse characteristics parameter will not be introduced specifically in literary, referring specifically to existing literature.
The slope of the ascending branchWherein, IPIt fights for heart beat cycle middle arteries in Fig. 1 the main wave of wave The amplitude of wave crest point A, IV1It fights for heart beat cycle middle arteries in Fig. 1 the amplitude of the starting trough point B of wave, TPFor heart beat cycle in Fig. 1 The corresponding moment values of main wave wave crest point A of middle pulse wave, TV1For heart beat cycle middle arteries in Fig. 1 fight wave starting trough point B correspond to At the time of value.
The amplitude difference PPG_AID=of the ascending branch | IP-IV1|, wherein, IPFight the master of wave for heart beat cycle middle arteries in Fig. 1 The amplitude of wave wave crest point A, IV1It fights for heart beat cycle middle arteries in Fig. 1 the amplitude of the starting trough point B of wave.
The area coverage of the ascending branchWherein, P fights wave for heart beat cycle middle arteries in Fig. 1 Main wave wave crest point A, V1Starting trough point B, i for pulse wave in heart beat cycle are free variable, IiFor the amplitude of i points,For Terminate trough point V1Amplitude.It is understood that the area coverage of ascending branch is " 1 " region shown in Fig. 1.
The slope of the decentWherein, IPIt fights for heart beat cycle middle arteries in Fig. 1 the main wave of wave The amplitude of wave crest point A, IV2It fights for heart beat cycle middle arteries in Fig. 1 the amplitude of the terminal trough point C of wave, TPFor heart beat cycle in Fig. 1 The corresponding moment values of main wave wave crest point A of middle pulse wave, TV2For heart beat cycle middle arteries in Fig. 1 fight wave terminal trough point C correspond to At the time of value.
The amplitude difference PPG_DID=of the decent | IP-IV2|, wherein, IPFight the master of wave for heart beat cycle middle arteries in Fig. 1 The amplitude of wave wave crest point A, IV2It fights for heart beat cycle middle arteries in Fig. 1 the amplitude of the terminal trough point C of wave.
The area coverage of the decentWherein, P fights for heart beat cycle middle arteries in Fig. 1 Main wave the wave crest point A, V of wave2End trough point C, i for pulse wave in heart beat cycle are free variable, IiFor the amplitude of i points, To terminate trough point V2Amplitude.It is understood that the area coverage of decent is " 2 " region shown in Fig. 1.
In order to real-time continuous blood pressure is measured, the present invention proposes a kind of continuous BP measurement equipment, this is continuous Blood pressure measurement device is able to carry out a kind of blood pressure measuring method disclosed by the embodiments of the present invention, the specific step of the blood pressure measuring method Suddenly it sees below, first is not unfolded to describe herein.The continuous BP measurement equipment real-time continuously can measure blood pressure Principle be：Blood pressure appraising model is established in the continuous BP measurement equipment, which can reflect tested First pulse characteristics parameter of the pulse wave of object and the relationship of pressure value.Continuous BP measurement equipment passes through real-time to pulse wave It continuously measures so as to obtain real-time first pulse characteristics parameter, and real-time pulse characteristics parameter is input to blood pressure and is estimated Calculate model, it is possible to obtain the real-time pressure value of measurand real-time continuously.Wherein, pressure value can be diastolic pressure and contraction In pressure any one or both combination.Continuous BP measurement equipment can be real to the first pulse characteristics parameter of pulse wave When the reason of continuously measuring be that continuous BP measurement equipment is by being placed on the external measuring point of measurand Photoelectric sensor measurement obtains pulse wave, photoelectric sensor will measure again obtained pulse wave be sent to processor calculate and It analyzes to obtain pulse wave characteristic parameters.Wherein, measuring point can be that finger tip artery, ear-lobe artery, wrist artery etc. are any The superficial artery of pulse wave can be measured.Since pulse wave can be measured by being placed on the external photoelectric sensor of measurand It arrives, so, continuous BP measurement equipment of the invention is noninvasive (will not cause wound to human body), moreover, photoelectric sensing Device can acquire the pulse wave of measurand real-time continuously, so, blood pressure measurement device real-time continuous can estimate naturally The pressure value of measurand.More specific process see a kind of continuous BP measurement method hereinafter.
In embodiments of the present invention, six the first pulse characteristics parameters can be used alone, can also be by six the first arteries and veins Characteristic parameter of fighting is some or all of to join together to use.Moreover, by linear regression model (LRM), nonlinear regression model (NLRM) or Machine learning model, by six the first pulse characteristics argument sections or whole effects used of joining together than being used alone six The estimation accuracy higher of any one in a first pulse characteristics parameter.It is understood that since length is limited, herein Department pattern is only listed, also more regressive prediction models just do not list one by one herein.
As shown in Fig. 2, the embodiment of the present invention proposes a kind of continuous BP measurement method.The continuous blood of the embodiment of the present invention Pressure measuring method includes the following steps：
210：Continuous BP measurement equipment samples the pulse wave of measurand to obtain sample pulse characteristics parameter, And obtain the reference pressure value of the measurand.
In the embodiment of the present invention, the pulse characteristics parameter is the spy of pulse wave of the measurand in heart beat cycle Parameter is levied, the pulse characteristics parameter includes the first pulse characteristics parameter, and the first pulse characteristics parameter includes：Ascending branch Slope, the amplitude difference of ascending branch, the area coverage of ascending branch, the slope of decent, the amplitude difference of decent and decent At least one of area coverage.In an alternate embodiment of the invention, pulse characteristics parameter further includes the second pulse characteristics parameter, described Second pulse characteristics parameter includes pulse wave transmission time, pulse wave wave crest and trough Amplitude Ratio, main wave height, dicrotic notch height Degree, dicrotic notch relative altitude, dicrotic pulse wave height, dicrotic wave relative altitude, the minimum of pulse wave data waveform, the pulsation period, The time ratios of duration of diastole, systole phase and diastole, the area ratio of main wave rise time, systole phase and diastole In the rate of climb of value, the area of pulse wave data waveform, the slope of pulse wave wave crest to dicrotic notch and pulse wave at least It is a kind of.
In embodiments of the present invention, the sampling pulse characteristics parameter of measurand is sampled by continuous BP measurement equipment It obtains.Wherein, continuous BP measurement equipment is noninvasive blood pressure measuring instrument, and is the measuring instrument of no cuff type.Even Continuous blood pressure measurement device be designed to it is wearable, in order to which user carries out blood pressure measurement, and will not be because of quilt whenever and wherever possible It surveys object movement or movement and continuous BP measurement equipment is caused to be detached with measurand.
In the embodiment of the present invention, the reference pressure value of the measurand is measured by accurate blood pressure measuring instrument It arrives, and continuous BP measurement equipment is sent to by wireless or wired mode.In another embodiment, measurand Reference pressure value can be that medical worker etc. is manually entered into continuous BP measurement equipment.Wherein, accurate survey meter of blood pressure Device can be invasive instrument or noninvasive instrument.For example, when accurate blood pressure measuring instrument is invasive instrument, The precision blood pressure measuring instrument can be the vessel measurement blood pressure measuring apparatus that the conduit of pressure sensor is inserted directly into patient Device etc.；When accurate blood pressure measuring instrument is noninvasive instrument, the precision blood pressure measuring instrument can be mercurial sphygmomanometer or Promote association (AAMI, The Association for the Advancement of Medical by American Medical instrument ) etc. Instrumentation authoritative Medical Instruments certification authority's certification by ripe business machine etc..In addition, accurate blood It can be the measuring instrument of cuff type or the measuring instrument without cuff type to press measuring instrument.
It is understood that the pressure value of human body may change with the variation of time, in order to ensure in step 220 The accuracy of the figure parameters of blood pressure appraising model being calculated needs to ensure continuous BP measurement equipment sampling measurand Sampling pulse characteristics parameter and accurate blood pressure measuring instrument measure the reference blood pressure of measurand and be carried out at the same time.For example, In synchronization, continuous BP measurement equipment is in the sampling pulse characteristics of the right hand index finger tip sampling measurand of measurand Parameter, accurate blood pressure measuring instrument measure the reference blood pressure of measurand in the right arm of measurand.Alternatively, in synchronization, Continuous BP measurement equipment is in the sampling pulse characteristics parameter of the left wrist sampling measurand of measurand, accurate survey meter of blood pressure Device measures the reference blood pressure of measurand in the left arm of measurand.
220：Continuous BP measurement equipment is calculated according to described with reference to pressure value and the sample pulse characteristics parameter To the figure parameters of blood pressure appraising model.
In embodiments of the present invention, for different measurands, the blood pressure appraising model of different measurands Figure parameters it is typically different, so, formally using continuous BP measurement equipment to the real-time blood pressure of measurand Before value measures, need to join using the reference pressure value acquired in step 210 and the sample pulse characteristics Number calculates the figure parameters of blood pressure appraising model.Wherein, blood pressure appraising model includes linear regression model (LRM), nonlinear regression mould Type or machine learning model.It is understood that since length is limited, department pattern is only listed herein, also more Regressive prediction model does not just list one by one herein.
230：Continuous BP measurement equipment to the pulse wave of the measurand measure in real time every in real time so as to estimate It fights continuous pulse characteristics parameter.
240：The figure parameters and the real-time pulse characteristics parameter are inputted the blood by continuous BP measurement equipment Appraising model is pressed, so as to estimate the continuous blood pressure value of often fighting in real time of the measurand.
Continuous BP measurement method of the present invention is illustrated below by several specific embodiments, it is to be understood that Following several embodiments are intended merely to for understand explanation, and it is not intended that specific limit.
Embodiment one：The pulse characteristics parameter of measurand only takes first pulse characteristics parameter (for example, ascending branch Slope), at this point, blood pressure appraising model is linear regression model (LRM) y=Ax+B, wherein, A and B are the coefficient of linear regression model (LRM) Parameter, x are the slope of ascending branch, and y is pressure value.As shown in figure 3,
310：Continuous BP measurement equipment samples the slope of the ascending branch of measurand to obtain on two samples The slope x of ascending branch1, x2, meanwhile, obtain the measurand two refer to pressure value y1, y2。
320：Continuous BP measurement equipment is according to described with reference to pressure value y1, y2And the slope x of the sample ascending branch1, x2The figure parameters A and B of blood pressure appraising model is calculated.It specifically, can be by described with reference to pressure value y1, y2It is and described The slope x of sample ascending branch1, x2It is in y=Ax+B, so as to obtain equation group (1) to be updated to linear regression model (LRM) respectively：
Solving equations (1) can obtain,So linear regression model (LRM) can be expressed as
It is understood that it is calculated a figure parameters A's and figure parameters B above by double sampling Value, and in practical applications, can figure parameters A using being the rules such as least square fitting, be calculated by multiple repairing weld With the value of figure parameters B, to improve the accuracy of figure parameters A and B.
330：Continuous BP measurement equipment carries out measuring to obtain in real time in real time to the pulse wave of the measurand The slope x of ascending branchi。
340：Continuous BP measurement equipment is by the figure parametersIt is and described real-time The slope x of ascending branchiThe blood pressure appraising model is inputted, so as to estimate the continuous blood pressure value of often fighting in real time of the measurand
Embodiment two：The pulse characteristics parameter of measurand takes two the first pulse characteristics parameters (for example, ascending branch is oblique The slope of rate and decent), at this point, it is y=A that blood pressure appraising model, which is linear regression model (LRM),1xi1+A2xi2+ B. wherein, A1、A2 It is the figure parameters of linear regression model (LRM) with B, xi1For the slope of ascending branch, xi2For the slope of decent, y is pressure value, i For sampling instant.As shown in figure 4,
410：Continuous BP measurement equipment carries out the slope of the ascending branch of measurand and the slope of decent respectively Sampling is to obtain the slope (x of the slope of 3 groups of sample ascending branch and sample decent11, x12), (x21, x22) and (x31, x32), and obtain 3 reference pressure value (y of the measurand1, y2, y3).Wherein, x11, x21, x31It is the oblique of sample ascending branch The sampled value of rate, x12, x22, x32It is the sampled value of the slope of sample decent.
420：Continuous BP measurement equipment slope of the slope of sample ascending branch and the sample decent according to 3 groups (x11, x12), (x21, x22), (x31, x32) and 3 reference pressure value (y1, y2, y3) the coefficient ginseng of blood pressure appraising model is calculated Number A1、A2And B.It specifically, can be by the slope of sample ascending branch described in 3 groups and the slope (x of the sample decent11, x12), (x21, x22), (x31, x32) and 3 reference pressure value (y1, y2, y3) it is updated to linear regression model (LRM) respectively as y=A1xi1+ A2xi2In+B, so as to obtain equation group (2)：
Solving equations (2) can obtain, A1、A2And the value of B.
It is understood that a figure parameters A is calculated above by secondary sampling three times1, a figure parameters A2With The value of one figure parameters B, and in practical applications, it, using rules such as least square fittings, can be calculated by multiple repairing weld Obtain figure parameters A1、A2With the value of figure parameters B, to improve figure parameters A1、A2And the accuracy of B.
430：Continuous BP measurement equipment carries out measuring to obtain in real time in real time to the pulse wave of the measurand The slope x of ascending branchk1And the slope x of real-time decentk2。
440：Continuous BP measurement equipment is by the figure parameters A1、A2And the slope of B and the real-time ascending branch xi1And the slope x of real-time decenti2The blood pressure appraising model is inputted, so as to estimate often fighting in real time for the measurand Continuous blood pressure value yk=A1xk1+A2xk2+B。
Embodiment three：The pulse characteristics parameter of measurand takes a first pulse characteristics parameter (for example, ascending branch is oblique Rate) and a second pulse characteristics parameter (for example, pulse wave transmission time), at this point, blood pressure appraising model is linear regression Model c=k1a+k2b+k3, wherein, k1、k2And k3It is the figure parameters of linear regression model (LRM), a is the slope of the ascending branch, B is the pulse wave transmission time, and c is pressure value.As shown in figure 5,
510：Continuous BP measurement equipment to the slope and pulse wave transmission time of the ascending branch of measurand respectively into Row samples the slope and sample pulse wave transmission time (a to obtain 3 groups of sample ascending branch1, b1), (a2, b2) and (a3, b3), and obtain 3 reference pressure value (c of the measurand1, c2, c3).Wherein, a1, a2, a3It is the slope of sample ascending branch Sampled value, b1, b2, b3It is the sampled value of sample pulse wave transmission time.
520：Continuous BP measurement equipment is when the slope of sample ascending branch and the sample pulse wave transmit according to 3 groups Between (a1, b1), (a2, b2) and (a3, b3) and 3 reference pressure value (c1, c2, c3) coefficient of blood pressure appraising model is calculated Parameter k1, k2And k3.It specifically, can be by the slope of sample ascending branch described in 3 groups and the sample pulse wave transmission time (a1, b1), (a2, b2) and (a3, b3) and 3 reference pressure value (c1, c2, c3) it is updated to linear regression model (LRM) respectively as c= k1a+k2b+k3In, so as to obtain equation group (3)：
Solving equations (3) can obtain, k1, k2, k3Value.
It is understood that a figure parameters k is calculated above by sampling three times1, a figure parameters k2With one A figure parameters k3Value, and in practical applications, can be calculated by multiple repairing weld using rules such as least square fittings To figure parameters k1、k2And k3Value, to improve figure parameters k1, k2, k3Accuracy.
530：Continuous BP measurement equipment carries out measuring to obtain in real time in real time to the pulse wave of the measurand The slope a of ascending branchiAnd real-time pulse wave transmission time bi。
540：Continuous BP measurement equipment is by the figure parameters k1, k2, k3And the slope a of the real-time ascending branchiWith And real-time pulse wave transmission time biThe blood pressure appraising model is inputted, so as to estimate that often fighting in real time for the measurand is continuous Pressure value ci=k1ai+k2bi+k3。
In order to prove to carry out what real-time continuous pressure value measured using the first pulse wave characteristic parameters proposed by the present invention The precision that ratio of precision carries out real-time continuous pressure value measurement using the second pulse wave characteristic parameters used in the prior art is high, The continuous blood pressure data that experimenter acquires 22 volunteers are tested, so as to obtain the experimental result such as Fig. 6.
As shown in Figure 6 a, what region (a) represented in figure is using single first pulse wave characteristic parameters proposed by the present invention The experimental result of systolic pressure error mean that real-time continuous pressure value measurement obtains is carried out respectively；Region (b) represents in figure It is to carry out pressure value measurement real-time continuous respectively using single second pulse wave characteristic parameters that the prior art uses to obtain The experimental result of systolic pressure error mean；What region (c) represented in figure is using single first pulse baud proposed by the present invention Pulse wave transmission time in the second pulse wave characteristic parameters that the sign parametric joint prior art uses carries out real-time continuous respectively The obtained experimental result of systolic pressure error mean of pressure value measurement.Dark region is bigger in figure, represents that error is bigger, effect Fruit is poorer.It can be seen from the figure that the darker regions in region (b) are most in figure, the darker regions in region (a) are taken second place, region (c) Darker regions it is minimum.The longitudinal axis represents the sample number for calibration, from less to more, for the sample number of calibration More, estimation error is smaller, and effect is better.
As shown in Figure 6 b, what region (a) represented in figure is using single first pulse wave characteristic parameters proposed by the present invention The experimental result of diastolic pressure error mean that real-time continuous pressure value measurement obtains is carried out respectively；Region (b) represents in figure It is to carry out real-time continuous pressure value measurement respectively using single second pulse wave characteristic parameters that the prior art uses to obtain The experimental result of diastolic pressure error mean；What region (c) represented in figure is using single first pulse baud proposed by the present invention Pulse wave transmission time in the second pulse wave characteristic parameters that the sign parametric joint prior art uses carries out real-time continuous respectively The obtained experimental result of diastolic pressure error mean of pressure value measurement.Dark region is bigger in figure, represents that error is bigger, effect Fruit is poorer.It can be seen from the figure that the darker regions in region (b) are most in figure, the darker regions in region (a) are taken second place, region (c) Darker regions it is minimum.The longitudinal axis represents the sample number for calibration, from less to more, for the sample number of calibration More, estimation error is smaller, and effect is better.
As fig. 6 c, what region (a) represented in figure is using single first pulse wave characteristic parameters proposed by the present invention The experimental result of systolic pressure error to standard deviation that real-time continuous pressure value measurement obtains is carried out respectively；Region (b) represents in figure Be that single second pulse wave characteristic parameters used using the prior art carry out the receipts that real-time continuous pressure value measurement obtains The experimental result of contracting pressure error to standard deviation；What region (c) represented in figure is using single first pulse baud proposed by the present invention Pulse wave transmission time in the second pulse wave characteristic parameters that the sign parametric joint prior art uses carries out real-time continuous respectively The obtained experimental result of systolic pressure error to standard deviation of pressure value measurement.Dark region is bigger in figure, represents that error is bigger, Effect is poorer.It can be seen from the figure that the darker regions in region (b) are most in figure, the darker regions in region (a) are taken second place, region (c) darker regions are minimum.The longitudinal axis represents the sample number for calibration, from less to more, for the sample of calibration Number is more, and estimation error is smaller, and effect is better.
As shown in fig 6d, what region (a) represented in figure is using single first pulse wave characteristic parameters proposed by the present invention The experimental result of diastolic pressure error to standard deviation that real-time continuous pressure value measurement obtains is carried out respectively；Region (b) represents in figure Be that single second pulse wave characteristic parameters used using the prior art are carried out real-time continuous pressure value measurement and obtain respectively Diastolic pressure error to standard deviation experimental result；What region (c) represented in figure is using single first pulse proposed by the present invention Pulse wave transmission time in the second pulse wave characteristic parameters that the wave characteristic parametric joint prior art uses carries out in real time respectively The experimental result of diastolic pressure error to standard deviation that continuous pressure value measurement obtains.Dark region is bigger in figure, represents error Bigger, effect is poorer.It can be seen from the figure that the darker regions in region (b) are most in figure, the darker regions in region (a) are taken second place, The darker regions in region (c) are minimum.The longitudinal axis represents the sample number for calibration, from less to more, for the sampling of calibration Number of samples is more, and estimation error is smaller, and effect is better.
The above-mentioned method for illustrating the embodiment of the present invention, following for convenient for preferably implementing the embodiment of the present invention Said program correspondingly, is also provided below to coordinate the relevant device for implementing said program.
Refering to Fig. 7, Fig. 7 is a kind of structure diagram of continuous blood pressure measurer disclosed in the present invention is implemented.This implementation The continuous blood pressure measurer of example includes：Acquisition module 710, computing module 720, actual measurement module 730 and estimation block 740.
The acquisition module 710 is used to sample the pulse wave of measurand to obtain sample pulse characteristics parameter, And the reference pressure value of the measurand is obtained, wherein, the pulse characteristics parameter is the measurand in heart beat cycle In pulse wave characteristic parameter, the pulse characteristics parameter includes the first pulse characteristics parameter, first pulse characteristics ginseng Number includes：The slope of ascending branch, the amplitude difference of ascending branch, the area coverage of ascending branch, the slope of decent, decent amplitude At least one of difference and the area coverage of decent, the reference pressure value of the measurand is by accurate blood pressure measurement What apparatus measures obtained；
The computing module 720 is used to be calculated with reference to pressure value and the sample pulse characteristics parameter according to described The figure parameters of blood pressure appraising model；
The actual measurement module 730 is used to that the pulse wave of the measurand measure so as to obtain real-time pulse in real time Characteristic parameter；
The estimation block 740 is used to the figure parameters and the real-time pulse characteristics parameter inputting the blood pressure Appraising model, so as to estimate the continuous blood pressure value of often fighting in real time of the measurand.
Optionally, the slope of the ascending branchWherein, IPMaster for pulse wave in heart beat cycle The amplitude of wave wave crest point, IV1For the amplitude of the starting trough point of pulse wave in heart beat cycle, TPFor pulse wave in heart beat cycle The corresponding moment value of main wave wave crest point, TV1The corresponding moment value of starting trough point for pulse wave in heart beat cycle；
The amplitude difference PPG_AID=of the ascending branch | IP-IV1|, wherein, IPMain wave wave for pulse wave in heart beat cycle The amplitude of peak dot, IV1Amplitude for the starting trough point of pulse wave in heart beat cycle；
The area coverage of the ascending branchWherein, P is the master of pulse wave in heart beat cycle Wave wave crest point, V1For the starting trough point of pulse wave in heart beat cycle, i is free variable, IiFor the amplitude of i points,To terminate wave Valley point V1Amplitude；
The slope of the decentWherein, IPMain wave wave crest point for pulse wave in heart beat cycle Amplitude, IV2For the amplitude of the terminal trough point of pulse wave in heart beat cycle, TPMain wave wave crest for pulse wave in heart beat cycle The corresponding moment value of point, TV2The corresponding moment value of terminal trough point for pulse wave in heart beat cycle；
The amplitude difference PPG_DID=of the decent | IP-IV2|, wherein, IPMain wave wave for pulse wave in heart beat cycle The amplitude of peak dot, IV2Amplitude for the terminal trough point of pulse wave in heart beat cycle；
The area coverage of the decentWherein, P is the master of pulse wave in heart beat cycle Wave wave crest point, V2For the end trough point of pulse wave in heart beat cycle, i is free variable, IiFor the amplitude of i points,To terminate Trough point V2Amplitude.
Optionally, the blood pressure appraising model is linear regression model (LRM), nonlinear regression model (NLRM) or machine learning mould Type.
Optionally, the linear regression model (LRM) is y=Ax+B, wherein, A and B are the figure parameters of linear regression model (LRM), X is pulse characteristics parameter, and y is pressure value.
Optionally, the pulse characteristics parameter further includes the second pulse wave characteristic parameters, the second pulse wave characteristic ginseng Number includes：Pulse wave transmission time, pulse wave wave crest and trough Amplitude Ratio, main wave height, dicrotic notch height, dicrotic notch are relatively high Degree, dicrotic pulse wave height, dicrotic wave relative altitude, the minimum of pulse wave data waveform, the pulsation period, diastole it is lasting when Between, the time ratios of systole phase and diastole, area ratio, the pulse wave data of main wave rise time, systole phase and diastole At least one of rate of climb of the area of waveform, the slope of pulse wave wave crest to dicrotic notch and pulse wave.
Optionally, the linear regression model (LRM) is c=k1a+k2b+k3, wherein, k1、k2And k3It is linear regression model (LRM) Figure parameters, a are the first pulse characteristics parameter, and b is the second pulse characteristics parameter, and c is pressure value.
The continuous blood pressure measurer of the embodiment of the present invention can realize the side of the continuous BP measurement as shown in Fig. 2 to 5 Method, referring specifically to Fig. 2 to 5 and related embodiment, it is no longer repeated herein.
Referring to Fig. 8, continuous BP measurement equipment provided by the embodiments of the present application includes：Storage unit 810, communication interface 820 and the processor 830 that is coupled with the storage unit 810 and communication interface 820.The storage unit 810 refers to for storing Enable, the processor 820 for performing described instruction, the communication interface 820 be used under the control of the processor 830 with Other equipment communicates.It is above-mentioned can the application to be performed according to described instruction when the processor 830 is performing described instruction Any one blood pressure measuring method in embodiment.
Processor 830 can also claim central processing unit (CPU, Central Processing Unit).Storage unit 810 It can include read-only memory and random access memory, and instruction and data etc. is provided to processor 830.Storage unit 810 A part may also include nonvolatile RAM.Each component of the device of wallpaper is replaced in specific application for example It is coupled by bus system.Bus system can also include power bus, control other than it may include data/address bus Bus and status signal bus in addition etc..But for the sake of clear explanation, various buses are all designated as bus system 840 in figure. The method that the embodiments of the present invention disclose can be applied to realize in processor 830 or by processor 830.Processor 830 may It is a kind of IC chip, the processing capacity with signal.During realization, each step of the above method can pass through place It manages the integrated logic circuit of the hardware in device 830 or the instruction of software form is completed.Wherein, above-mentioned processor 830 can be General processor, digital signal processor, application-specific integrated circuit, ready-made programmable gate array or other programmable logic devices Part, discrete gate or transistor logic, discrete hardware components.Implementation of the present invention can be realized or be performed to processor 830 Disclosed each method, step and logic diagram in example.General processor can be that microprocessor or the processor can also It is any conventional processor etc..The step of method with reference to disclosed in the embodiment of the present invention, can be embodied directly in hardware decoding Processor performs completion or performs completion with the hardware in decoding processor and software module combination.Software module can position In random access memory, flash memory, read-only memory, programmable read only memory or electrically erasable programmable memory, register In the storage medium for waiting this fields maturation.The storage medium is located at storage unit 810, such as storage list can be read in processor 830 Information in member 810, with reference to the step of its hardware completion above method.
The pulse wave of measurand is sampled to obtain sample pulse characteristics parameter, and obtain the measurand With reference to pressure value, wherein, the pulse characteristics parameter is the characteristic parameter of pulse wave of the measurand in heart beat cycle, The pulse characteristics parameter includes the first pulse characteristics parameter, and the first pulse characteristics parameter includes：The slope of ascending branch, on The amplitude difference of ascending branch, the area coverage of ascending branch, the slope of decent, the amplitude difference of decent and decent area coverage At least one of, the reference pressure value of the measurand is obtained by accurate blood pressure measuring instrument measurement；
According to the coefficient that blood pressure appraising model is calculated with reference to pressure value and the sample pulse characteristics parameter Parameter；
The pulse wave of the measurand measure in real time so as to obtain real-time pulse characteristics parameter；
The figure parameters and the real-time pulse characteristics parameter are inputted into the blood pressure appraising model, so as to estimate State the continuous blood pressure value of often fighting in real time of measurand.
Optionally, the slope of the ascending branchWherein, IPMaster for pulse wave in heart beat cycle The amplitude of wave wave crest point, IV1For the amplitude of the starting trough point of pulse wave in heart beat cycle, TPFor pulse wave in heart beat cycle The corresponding moment value of main wave wave crest point, TV1The corresponding moment value of starting trough point for pulse wave in heart beat cycle；
The amplitude difference PPG_AID=of the ascending branch | IP-IV1|, wherein, IPMain wave wave for pulse wave in heart beat cycle The amplitude of peak dot, IV1Amplitude for the starting trough point of pulse wave in heart beat cycle；
The area coverage of the ascending branchWherein, P is the master of pulse wave in heart beat cycle Wave wave crest point, V1For the starting trough point of pulse wave in heart beat cycle, i is free variable, IiFor the amplitude of i points,To terminate wave Valley point V1Amplitude；
The slope of the decentWherein, IPMain wave wave crest point for pulse wave in heart beat cycle Amplitude, IV2For the amplitude of the terminal trough point of pulse wave in heart beat cycle, TPMain wave wave crest for pulse wave in heart beat cycle The corresponding moment value of point, TV2The corresponding moment value of terminal trough point for pulse wave in heart beat cycle；
The amplitude difference PPG_DID=of the decent | IP-IV2|, wherein, IPMain wave wave for pulse wave in heart beat cycle The amplitude of peak dot, IV2Amplitude for the terminal trough point of pulse wave in heart beat cycle；
The area coverage of the decentWherein, P is the master of pulse wave in heart beat cycle Wave wave crest point, V2For the end trough point of pulse wave in heart beat cycle, i is free variable, IiFor the amplitude of i points,To terminate Trough point V2Amplitude.
Optionally, the blood pressure appraising model is linear regression model (LRM), nonlinear regression model (NLRM) or machine learning mould Type.
Optionally, the linear regression model (LRM) is y=Ax+B, wherein, A and B are the figure parameters of linear regression model (LRM), X is pulse characteristics parameter, and y is pressure value.
Optionally, the pulse characteristics parameter further includes the second pulse wave characteristic parameters, the second pulse wave characteristic ginseng Number includes：Pulse wave transmission time, pulse wave wave crest and trough Amplitude Ratio, main wave height, dicrotic notch height, dicrotic notch are relatively high Degree, dicrotic pulse wave height, dicrotic wave relative altitude, the minimum of pulse wave data waveform, the pulsation period, diastole it is lasting when Between, the time ratios of systole phase and diastole, area ratio, the pulse wave data of main wave rise time, systole phase and diastole At least one of rate of climb of the area of waveform, the slope of pulse wave wave crest to dicrotic notch and pulse wave.
Optionally, the linear regression model (LRM) is c=k1a+k2b+k3, wherein, k1、k2And k3It is linear regression model (LRM) Figure parameters, a are the first pulse characteristics parameter, and b is the second pulse characteristics parameter, and c is pressure value.
One of ordinary skill in the art will appreciate that realizing all or part of flow in above-described embodiment method, being can be with Relevant hardware is instructed to complete by computer program, the program can be stored in a computer read/write memory medium In, the program is when being executed, it may include such as the flow of the embodiment of above-mentioned each method.Wherein, the storage medium can be magnetic Dish, CD, read-only memory (Read-Only Memory, ROM) or random access memory (Random Access Memory, RAM) etc..
Above disclosed is only a kind of preferred embodiment of the present invention, cannot limit the power of the present invention with this certainly Sharp range one of ordinary skill in the art will appreciate that realizing all or part of flow of above-described embodiment, and is weighed according to the present invention Profit requires made equivalent variations, still falls within and invents covered range.

Claims (13)

  1. A kind of 1. continuous BP measurement method, which is characterized in that include the following steps：
    Continuous BP measurement equipment samples the pulse wave of measurand to obtain sample pulse characteristics parameter, and obtains institute The reference pressure value of measurand is stated, wherein, the pulse characteristics parameter is pulse of the measurand in heart beat cycle The characteristic parameter of wave, the pulse characteristics parameter include the first pulse characteristics parameter, and the first pulse characteristics parameter includes：On The slope of ascending branch, the amplitude difference of ascending branch, the area coverage of ascending branch, the slope of decent, decent amplitude difference and under At least one of area coverage of descending branch, the reference pressure value of the measurand are measured by accurate blood pressure measuring instrument It obtains；
    Continuous BP measurement equipment is calculated blood pressure and estimates according to described with reference to pressure value and the sample pulse characteristics parameter Calculate the figure parameters of model；
    Continuous BP measurement equipment to the pulse wave of the measurand measure in real time joins so as to obtain real-time pulse characteristics Number；
    The figure parameters and the real-time pulse characteristics parameter are inputted the blood pressure and estimate mould by continuous BP measurement equipment Type, so as to estimate the continuous blood pressure value of often fighting in real time of the measurand.
  2. 2. according to the method described in claim 1, it is characterized in that,
    The slope of the ascending branchWherein, IPWidth for the main wave wave crest point of pulse wave in heart beat cycle Value, IV1For the amplitude of the starting trough point of pulse wave in heart beat cycle, TPMain wave wave crest point pair for pulse wave in heart beat cycle Value at the time of answering, TV1The corresponding moment value of starting trough point for pulse wave in heart beat cycle；
    The amplitude difference PPG_AID=of the ascending branch | IP-IV1|, wherein, IPFor the main wave wave crest point of pulse wave in heart beat cycle Amplitude, IV1Amplitude for the starting trough point of pulse wave in heart beat cycle；
    The area coverage of the ascending branchWherein, P is the main wave wave of pulse wave in heart beat cycle Peak dot, V1For the starting trough point of pulse wave in heart beat cycle, i is free variable, IiFor the amplitude of i points,To terminate trough point V1Amplitude；
    The slope of the decentWherein, IPWidth for the main wave wave crest point of pulse wave in heart beat cycle Value, IV2For the amplitude of the terminal trough point of pulse wave in heart beat cycle, TPMain wave wave crest point pair for pulse wave in heart beat cycle Value at the time of answering, TV2The corresponding moment value of terminal trough point for pulse wave in heart beat cycle；
    The amplitude difference of the decentWherein, IPMain wave wave crest point for pulse wave in heart beat cycle Amplitude, IV2Amplitude for the terminal trough point of pulse wave in heart beat cycle；
    The area coverage of the decentWherein, P is the main wave wave of pulse wave in heart beat cycle Peak dot, V2For the end trough point of pulse wave in heart beat cycle, i is free variable, IiFor the amplitude of i points,To terminate trough Point V2Amplitude.
  3. 3. according to the method described in claim 1, it is characterized in that, the blood pressure appraising model include linear regression model (LRM), it is non- Linear regression model (LRM) or machine learning model.
  4. 4. according to the method described in claim 3, it is characterized in that, the linear regression model (LRM) be y=Ax+B, wherein, A and B It is the figure parameters of linear regression model (LRM), x is pulse characteristics parameter, and y is pressure value.
  5. 5. according to the method described in claim 3, it is characterized in that, the pulse characteristics parameter further includes the second pulse wave characteristic Parameter, second pulse wave characteristic parameters include：Pulse wave transmission time, pulse wave wave crest and trough Amplitude Ratio, main wave height Degree, dicrotic notch height, dicrotic notch relative altitude, dicrotic pulse wave height, dicrotic wave relative altitude, pulse wave data waveform it is minimum Value, pulsation period, the duration of diastole, systole phase and the time ratios of diastole, the main wave rise time, the systole phase and relax The area ratio of phase, the area of pulse wave data waveform, pulse wave wave crest to dicrotic notch slope and pulse wave rising At least one of speed.
  6. 6. according to the method described in claim 5, it is characterized in that, the linear regression model (LRM) is c=k1a+k2b+k3, wherein, k1、k2And k3It is the figure parameters of linear regression model (LRM), a is the first pulse characteristics parameter, and b is special for second pulse Parameter is levied, c is pressure value.
  7. 7. a kind of continuous blood pressure measurer, which is characterized in that including acquisition module, computing module, actual measurement module and estimation Module,
    The acquisition module is used to sample the pulse wave of measurand to obtain sample pulse characteristics parameter, and obtain institute The reference pressure value of measurand is stated, wherein, the pulse characteristics parameter is pulse of the measurand in heart beat cycle The characteristic parameter of wave, the pulse characteristics parameter include the first pulse characteristics parameter, and the first pulse characteristics parameter includes：On The slope of ascending branch, the amplitude difference of ascending branch, the area coverage of ascending branch, the slope of decent, decent amplitude difference and under At least one of area coverage of descending branch, the reference pressure value of the measurand are measured by accurate blood pressure measuring instrument It obtains；
    The computing module is used to that blood pressure to be calculated and estimate with reference to pressure value and the sample pulse characteristics parameter according to described Calculate the figure parameters of model；
    The actual measurement module is used to that the pulse wave of the measurand measure in real time so as to obtain real-time pulse characteristics to join Number；
    The estimation block is used to the figure parameters and the real-time pulse characteristics parameter inputting the blood pressure estimation mould Type, so as to estimate the continuous blood pressure value of often fighting in real time of the measurand.
  8. 8. device according to claim 7, which is characterized in that the slope of the ascending branchIts In, IPFor the amplitude of the main wave wave crest point of pulse wave in heart beat cycle, IV1For the starting trough point of pulse wave in heart beat cycle Amplitude, TPFor the corresponding moment value of main wave wave crest point of pulse wave in heart beat cycle, TV1Starting for pulse wave in heart beat cycle The corresponding moment value of trough point；
    The amplitude difference PPG_AID=of the ascending branch | IP-IV1|, wherein, IPFor the main wave wave crest point of pulse wave in heart beat cycle Amplitude, IV1Amplitude for the starting trough point of pulse wave in heart beat cycle；
    The area coverage of the ascending branchWherein, P is the main wave wave of pulse wave in heart beat cycle Peak dot, V1For the starting trough point of pulse wave in heart beat cycle, i is free variable, IiFor the amplitude of i points,To terminate trough point V1Amplitude；
    The slope of the decentWherein, IPWidth for the main wave wave crest point of pulse wave in heart beat cycle Value, IV2For the amplitude of the terminal trough point of pulse wave in heart beat cycle, TPMain wave wave crest point pair for pulse wave in heart beat cycle Value at the time of answering, TV2The corresponding moment value of terminal trough point for pulse wave in heart beat cycle；
    The amplitude difference PPG_DID=of the decent | IP-IV2|, wherein, IPFor the main wave wave crest point of pulse wave in heart beat cycle Amplitude, IV2Amplitude for the terminal trough point of pulse wave in heart beat cycle；
    The area coverage of the decentWherein, P is the main wave wave of pulse wave in heart beat cycle Peak dot, V2For the end trough point of pulse wave in heart beat cycle, i is free variable, IiFor the amplitude of i points,To terminate trough Point V2Amplitude.
  9. 9. device according to claim 7, which is characterized in that the blood pressure appraising model includes linear regression model (LRM), non- Linear regression model (LRM) or machine learning model.
  10. 10. device according to claim 9, which is characterized in that the linear regression model (LRM) is y=Ax+B, wherein, A and B It is the figure parameters of linear regression model (LRM), x is pulse characteristics parameter, and y is pressure value.
  11. 11. device according to claim 9, which is characterized in that the pulse characteristics parameter further includes the second pulse baud Parameter is levied, second pulse wave characteristic parameters include：Pulse wave transmission time, pulse wave wave crest and trough Amplitude Ratio, main wave Highly, dicrotic notch height, dicrotic notch relative altitude, dicrotic pulse wave height, dicrotic wave relative altitude, pulse wave data waveform it is minimum Value, pulsation period, the duration of diastole, systole phase and the time ratios of diastole, the main wave rise time, the systole phase and relax The area ratio of phase, the area of pulse wave data waveform, pulse wave wave crest to dicrotic notch slope and pulse wave rising At least one of speed.
  12. 12. according to the devices described in claim 11, which is characterized in that the linear regression model (LRM) is c=k1a+k2b+k3, In, k1、k2And k3It is the figure parameters of linear regression model (LRM), a is the first pulse characteristics parameter, and b is second pulse Characteristic parameter, c are pressure value.
  13. 13. a kind of continuous BP measurement equipment, which is characterized in that the equipment includes interface circuit, memory and processor, Wherein, batch processing code is stored in memory, and processor is used to call the program code stored in memory, for performing It operates below：
    The pulse wave of measurand is sampled to obtain sample pulse characteristics parameter, and obtain the reference of the measurand Pressure value, wherein, the pulse characteristics parameter is the characteristic parameter of pulse wave of the measurand in heart beat cycle, described Pulse characteristics parameter includes the first pulse characteristics parameter, and the first pulse characteristics parameter includes：Slope, the ascending branch of ascending branch Amplitude difference, the area coverage of ascending branch, the slope of decent, the amplitude difference of decent and decent area coverage in At least one, the reference pressure value of the measurand is obtained by accurate blood pressure measuring instrument measurement；According to the ginseng It examines pressure value and the figure parameters of blood pressure appraising model is calculated in the sample pulse characteristics parameter；To the measurand Pulse wave carry out in real time measure so as to obtain real-time pulse characteristics parameter；The figure parameters and the real-time pulse are special It levies parameter and inputs the blood pressure appraising model, so as to obtain the continuous blood pressure value of often fighting in real time of the measurand.
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CN116458845A (en) * 2023-04-07 2023-07-21 电子科技大学 Wearable traditional chinese medical science physique evaluation system of intelligence

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