CN108250157B - Method for synthesizing N- [2- (2-arylbenzothiazole) ] -amide under catalysis of rhodium - Google Patents
Method for synthesizing N- [2- (2-arylbenzothiazole) ] -amide under catalysis of rhodium Download PDFInfo
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- CN108250157B CN108250157B CN201810184866.0A CN201810184866A CN108250157B CN 108250157 B CN108250157 B CN 108250157B CN 201810184866 A CN201810184866 A CN 201810184866A CN 108250157 B CN108250157 B CN 108250157B
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- 238000000034 method Methods 0.000 title claims abstract description 15
- 238000006555 catalytic reaction Methods 0.000 title claims abstract description 8
- 229910052703 rhodium Inorganic materials 0.000 title claims abstract description 8
- 239000010948 rhodium Substances 0.000 title claims abstract description 8
- MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 title claims abstract description 8
- 230000002194 synthesizing effect Effects 0.000 title claims abstract description 8
- -1 silver hexafluoroantimonate Chemical compound 0.000 claims abstract description 37
- 238000006243 chemical reaction Methods 0.000 claims abstract description 22
- QVLTVILSYOWFRM-UHFFFAOYSA-L CC1=C(C)C(C)([Rh](Cl)Cl)C(C)=C1C Chemical class CC1=C(C)C(C)([Rh](Cl)Cl)C(C)=C1C QVLTVILSYOWFRM-UHFFFAOYSA-L 0.000 claims abstract description 17
- 238000003756 stirring Methods 0.000 claims abstract description 17
- IOJUPLGTWVMSFF-UHFFFAOYSA-N cyclobenzothiazole Natural products C1=CC=C2SC=NC2=C1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000003054 catalyst Substances 0.000 claims abstract description 7
- 239000000654 additive Substances 0.000 claims abstract description 3
- 230000000996 additive effect Effects 0.000 claims abstract description 3
- 239000000376 reactant Substances 0.000 claims abstract description 3
- 239000002904 solvent Substances 0.000 claims abstract description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 55
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 36
- 239000003208 petroleum Substances 0.000 claims description 18
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 17
- 238000007789 sealing Methods 0.000 claims description 17
- 239000000741 silica gel Substances 0.000 claims description 17
- 229910002027 silica gel Inorganic materials 0.000 claims description 17
- 239000012043 crude product Substances 0.000 claims description 16
- 239000003480 eluent Substances 0.000 claims description 16
- 239000003960 organic solvent Substances 0.000 claims description 16
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims description 16
- 239000004810 polytetrafluoroethylene Substances 0.000 claims description 16
- 238000010898 silica gel chromatography Methods 0.000 claims description 16
- XBHOUXSGHYZCNH-UHFFFAOYSA-N 2-phenyl-1,3-benzothiazole Chemical group C1=CC=CC=C1C1=NC2=CC=CC=C2S1 XBHOUXSGHYZCNH-UHFFFAOYSA-N 0.000 claims description 13
- 238000001816 cooling Methods 0.000 claims description 13
- SCYULBFZEHDVBN-UHFFFAOYSA-N 1,1-Dichloroethane Chemical compound CC(Cl)Cl SCYULBFZEHDVBN-UHFFFAOYSA-N 0.000 claims description 12
- 239000012295 chemical reaction liquid Substances 0.000 claims description 12
- 125000000217 alkyl group Chemical group 0.000 claims description 6
- 238000003786 synthesis reaction Methods 0.000 claims description 5
- 229910052736 halogen Inorganic materials 0.000 claims description 4
- 150000002367 halogens Chemical class 0.000 claims description 4
- 229910052739 hydrogen Inorganic materials 0.000 claims description 4
- 239000001257 hydrogen Substances 0.000 claims description 4
- 150000002431 hydrogen Chemical class 0.000 claims description 4
- 125000003342 alkenyl group Chemical group 0.000 claims description 2
- 125000003545 alkoxy group Chemical group 0.000 claims description 2
- 125000003118 aryl group Chemical group 0.000 claims description 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 2
- 125000003107 substituted aryl group Chemical group 0.000 claims description 2
- 230000015572 biosynthetic process Effects 0.000 claims 4
- 239000002245 particle Substances 0.000 claims 1
- 239000002994 raw material Substances 0.000 abstract description 7
- 125000000524 functional group Chemical group 0.000 abstract description 2
- 231100000053 low toxicity Toxicity 0.000 abstract 1
- 238000001308 synthesis method Methods 0.000 abstract 1
- HEDRZPFGACZZDS-MICDWDOJSA-N Trichloro(2H)methane Chemical compound [2H]C(Cl)(Cl)Cl HEDRZPFGACZZDS-MICDWDOJSA-N 0.000 description 40
- 235000019439 ethyl acetate Nutrition 0.000 description 18
- 238000001644 13C nuclear magnetic resonance spectroscopy Methods 0.000 description 10
- 238000005160 1H NMR spectroscopy Methods 0.000 description 10
- 239000000047 product Substances 0.000 description 10
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 9
- 238000010828 elution Methods 0.000 description 9
- 238000005481 NMR spectroscopy Methods 0.000 description 8
- 238000004949 mass spectrometry Methods 0.000 description 8
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 6
- 238000004821 distillation Methods 0.000 description 6
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 3
- WKRCOZSCENDENK-UHFFFAOYSA-N 4-(1,3-benzothiazol-2-yl)aniline Chemical compound C1=CC(N)=CC=C1C1=NC2=CC=CC=C2S1 WKRCOZSCENDENK-UHFFFAOYSA-N 0.000 description 2
- 206010006187 Breast cancer Diseases 0.000 description 2
- 208000026310 Breast neoplasm Diseases 0.000 description 2
- WTDHULULXKLSOZ-UHFFFAOYSA-N Hydroxylamine hydrochloride Chemical compound Cl.ON WTDHULULXKLSOZ-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 239000012299 nitrogen atmosphere Substances 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- UAKADWQYPAMUOJ-UHFFFAOYSA-N 2-(2-methoxyphenyl)-1,3-benzothiazole Chemical compound COC1=CC=CC=C1C1=NC2=CC=CC=C2S1 UAKADWQYPAMUOJ-UHFFFAOYSA-N 0.000 description 1
- GWTBGUYMQNKBQX-UHFFFAOYSA-N 2-(2-methoxyphenyl)-5-methyl-1,3-benzothiazole Chemical compound COC1=CC=CC=C1C1=NC2=CC(C)=CC=C2S1 GWTBGUYMQNKBQX-UHFFFAOYSA-N 0.000 description 1
- AMWVFOHECZHTQT-UHFFFAOYSA-N 2-(2-methylphenyl)-1,3-benzothiazole Chemical compound CC1=CC=CC=C1C1=NC2=CC=CC=C2S1 AMWVFOHECZHTQT-UHFFFAOYSA-N 0.000 description 1
- WPKWWUOUYBJTGE-UHFFFAOYSA-N 2-(3-methylphenyl)-1,3-benzothiazole Chemical compound CC1=CC=CC(C=2SC3=CC=CC=C3N=2)=C1 WPKWWUOUYBJTGE-UHFFFAOYSA-N 0.000 description 1
- SVTDXKPYBJXBJR-UHFFFAOYSA-N 5-chloro-2-phenyl-1,3-benzothiazole Chemical compound N=1C2=CC(Cl)=CC=C2SC=1C1=CC=CC=C1 SVTDXKPYBJXBJR-UHFFFAOYSA-N 0.000 description 1
- 229940124087 DNA topoisomerase II inhibitor Drugs 0.000 description 1
- 238000005863 Friedel-Crafts acylation reaction Methods 0.000 description 1
- 229930182559 Natural dye Natural products 0.000 description 1
- 239000000317 Topoisomerase II Inhibitor Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000001773 anti-convulsant effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 239000001961 anticonvulsive agent Substances 0.000 description 1
- 229960003965 antiepileptics Drugs 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 229940041181 antineoplastic drug Drugs 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 150000004982 aromatic amines Chemical class 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 150000001728 carbonyl compounds Chemical class 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- LFKYBJLFJOOKAE-UHFFFAOYSA-N imidazol-2-ylidenemethanone Chemical compound O=C=C1N=CC=N1 LFKYBJLFJOOKAE-UHFFFAOYSA-N 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229940043355 kinase inhibitor Drugs 0.000 description 1
- GMMDZGHGMAMEMV-UHFFFAOYSA-N n-[2-(1,3-benzothiazol-2-yl)phenyl]-4-methylbenzamide Chemical compound C1=CC(C)=CC=C1C(=O)NC1=CC=CC=C1C1=NC2=CC=CC=C2S1 GMMDZGHGMAMEMV-UHFFFAOYSA-N 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- UBAOFCNBCAZEBL-UHFFFAOYSA-N octanamide Chemical compound CCCCCCCC(N)=O.CCCCCCCC(N)=O UBAOFCNBCAZEBL-UHFFFAOYSA-N 0.000 description 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
- C07D277/66—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Catalysts (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
The invention discloses a method for synthesizing N- [2- (2-aryl benzothiazole) ] -amide by rhodium catalysis, which comprises the following steps: taking dichloro (pentamethylcyclopentadienyl) rhodium (III) dimer as a catalyst, silver hexafluoroantimonate as an additive, 2-arylbenzothiazole and 1,4, 2-bisoxazole-5-ketone as reactants, DCE as a solvent, stirring for 24h at the temperature of 110-120 ℃, and carrying out aftertreatment on a reaction solution after the reaction is finished to obtain N- [2- (2-arylbenzothiazole) ] -amide. The synthesis method has the characteristics of small catalyst dosage, low toxicity, easily-prepared raw materials, good functional group universality and the like.
Description
Technical Field
The invention belongs to the field of organic synthesis, and particularly relates to a method for synthesizing N- [2- (2-aryl benzothiazole) ] -amide by rhodium catalysis.
Background
Benzothiazole compounds have a wide range of biological activities, such as anticancer, antibacterial, anti-inflammatory, anticonvulsant and antioxidant effects, and also have topoisomerase II inhibitors, and some have been shown to have kinase inhibitors. For example, 2- (4-aminophenyl) benzothiazole (CJM-126) and derivatives thereof have high selective toxicity to breast cancer cells, half inhibition rate reaches nanomolar level, and structure-effect relation research shows that the biological structure of the CJM-126 is simply modified, so that the cytotoxic activity of the obtained compound (5F-203) to the breast cancer cells is improved by 2-3 times, and the two compounds enter a clinical research stage and are expected to become novel antitumor drugs. In addition, the obtained 2-aryl benzothiazole compound (GW610) also has good antitumor activity. In addition, carbonyl compounds are ubiquitous in functional molecules and are widely found in the natural products, dyes and pharmaceutical industries. The reactivity of the carbonyl group allows the introduction of other diverse functional groups, and efficient development of methods for providing carbonyl groups in molecules has attracted the interest of chemists. The traditional Friedel-Crafts acylation reaction has the limitation, so the invention of the raw material which is cheap and easy to obtain and utilizes a trace catalyst to synthesize the N- [2- (2-arylbenzothiazole) ] -amide has important value.
Disclosure of Invention
The invention aims to provide a method for synthesizing N- [2- (2-aryl benzothiazole) ] -amide by rhodium catalysis, which has the advantages of cheap and easily obtained raw materials, small catalyst dosage, simple and convenient reaction operation, good industrial application prospect and the like.
In order to achieve the purpose, the invention adopts the following technical scheme:
a method for synthesizing N- [2- (2-aryl benzothiazole) ] -amide by rhodium catalysis takes dichloro (pentamethyl cyclopentadienyl) rhodium (III) dimer as a catalyst, silver hexafluoroantimonate as an additive, 2-aryl benzothiazole and 1,4, 2-bisoxazole-5-ketone as reactants, and N- [2- (2-aryl benzothiazole) ] -amide is prepared by reaction in a DCE solvent, wherein the chemical reaction formula is as follows:
wherein R is1Selected from alkyl, cycloalkyl, alkenyl, aryl, substituted aryl; r2Selected from hydrogen, alkyl, halogen; r3Selected from hydrogen, alkyl, hydroxyl, halogen, alkoxy, nitro and amino.
Preferably, the 1,4, 2-bisoxazol-5-one is any one of the following formulas 1 to 14, and the 2-arylbenzothiazole is any one of the following formulas 15 to 43:
most preferably, the N- [2- (2-phenyl benzothiazole) ] -benzamide is prepared by using 3-phenyl-1, 4, 2-bisoxazole-5-ketone and 2-phenyl benzothiazole.
The method for synthesizing the N- [2- (2-aryl benzothiazole) ] -amide by rhodium catalysis comprises the following specific steps:
adding dichloro (pentamethylcyclopentadienyl) rhodium (III) dimer, silver hexafluoroantimonate, 2-arylbenzothiazole, 1,4, 2-bisoxazole-5-ketone and dichloroethane into a pressure-resistant tube, adding a polytetrafluoroethylene magnet, sealing, stirring at 120 ℃ for reaction for 24 hours, cooling to room temperature, detecting by TLC to finish the reaction, completely transferring the reaction liquid into a round-bottomed flask, adding a proper amount of 200-mesh silica gel, carrying out reduced pressure distillation to remove an organic solvent, carrying out silica gel column chromatography on the obtained crude product, and eluting by using ethyl acetate and petroleum ether as eluents to obtain N- [2- (2-arylbenzothiazole) ] -amide.
The mol ratio of dichloro (pentamethylcyclopentadienyl) rhodium (III) dimer, silver hexafluoroantimonate, 2-arylbenzothiazole and 1,4, 2-bisoxazole-5-ketone is 0.05:0.2:1: 1.5.
The invention has the beneficial effects that: the preparation of the raw materials of the 2-aryl benzothiazole and the 1,4, 2-bisoxazole-5-ketone is very easy, the dosage of the catalyst is very small, the general yield is good, the operation is simple, and the method has good industrial application prospect.
Detailed Description
In order to make the present invention more comprehensible, the present invention will be further described with reference to the following embodiments, but the present invention is not limited thereto.
Preparation of raw material 2-aryl benzothiazole: placing a polytetrafluoroethylene magnet into a 250mL round-bottom flask, adding 25mmol arylamine, 12.5mmol KI and 25mmol I2，37.5mmol NaHCO3，65mLH2O, 2.6mL of toluene, sealing, stirring in an ice bath at 0 ℃ for 8h, detecting by TLC, extracting, adding a proper amount of 200-mesh silica gel with 300 meshes, distilling under reduced pressure to remove the organic solvent, carrying out silica gel column chromatography on the obtained crude product, and eluting by using ethyl acetate and petroleum ether as eluents to obtain the O-iodoarylamine. Putting a polytetrafluoroethylene magnet into a 250mL round-bottom flask, adding 10mmol of o-iodoarylamine, 12mmol of aryl formyl chloride and 100mL of dichloromethane, sealing, stirring at normal temperature under nitrogen atmosphere for reaction for 2h, carrying out TLC detection reaction, carrying out reduced pressure distillation to remove dichloromethane, adding 6mmol of Lawson reagent, 0.05mmol of CuI and 100mL of toluene, sealing, refluxing at 110 ℃ under nitrogen atmosphere for 8h, cooling to room temperature, carrying out TLC detection reaction, extracting, adding a proper amount of 200-mesh 300-mesh silica gel, carrying out reduced pressure distillation to remove an organic solvent, carrying out silica gel column chromatography on an obtained crude product, and eluting by using ethyl acetate and petroleum ether as eluents to obtain the raw material 2-arylbenzothiazole.
Preparation of raw material 1,4, 2-bisoxazole-5-ketone: placing a polytetrafluoroethylene magnet into a 250mL round-bottom flask, adding 10mmol of aryl formyl chloride, 12mmol of hydroxylamine hydrochloride and 20mmol of K2CO3，50mL H2O and 50mL ethyl acetate, sealing, stirring at normal temperature for reaction for 8h, detecting by TLC, extracting, and adding a proper amount of 200-300 mesh silica gel, reduced pressure distillation to remove organic solvent, silica gel column chromatography of the obtained crude product, and elution with ethyl acetate and petroleum ether as eluent to obtain aryl hydroxamic acid. Putting a polytetrafluoroethylene magnet into a 250mL round-bottom flask, adding 5mmol of arylhydroxamic acid, 5mmol of carbonylimidazole and 100mL redistilled dichloromethane, sealing, stirring at normal temperature for reaction for 1h, detecting by TLC, adding a proper amount of 200-mesh silica gel and 300-mesh silica gel, distilling under reduced pressure to remove an organic solvent, carrying out silica gel column chromatography on the obtained crude product, and eluting by using ethyl acetate and petroleum ether as eluents to obtain the 1,4, 2-bisoxazole-5-one.
Example 1
Putting a polytetrafluoroethylene magnet into a 10mL pressure resistant tube, adding 0.01mmol of dichloro (pentamethylcyclopentadienyl) rhodium (III) dimer, 0.04mmol of silver hexafluoroantimonate, 0.2mmol of 2-phenylbenzothiazole, 0.3mmol of 3-phenyl-1, 4, 2-bisoxazole-5-ketone, finally adding 2mL of dichloroethane, sealing, stirring and reacting at 120 ℃ for 24h, cooling to room temperature, detecting by TLC, completely transferring the reaction liquid into a round-bottomed flask, adding a proper amount of 200-mesh 300-mesh silica gel, removing the organic solvent by reduced pressure distillation, and carrying out silica gel column chromatography on the obtained crude product and eluting by using ethyl acetate and petroleum ether as eluents to obtain N- [2- (2-phenylbenzothiazole) ] -benzamide (the separation yield is 94%). The following are the nmr characterization data for the product:
1H NMR(400MHz,CDCl3)δ13.38(s,1H),9.05(d,J＝8.4Hz,1H),8.24-8.22(m,2H),7.98 (d,J＝8.0Hz,1H),7.91(t,J＝8.4Hz,2H),7.61-7.51(m,5H),7.43(t,J＝7.6Hz,1H),7.19(t,J＝ 7.6Hz,1H).13C NMR(101MHz,CDCl3)δ169.02,166.30,152.74,138.46,135.62,133.35, 132.21,131.88,129.91,128.67,127.83,126.74,125.88,123.28,122.23,121.58,120.87,119.37.
example 2
Putting a polytetrafluoroethylene magnet into a pressure-resistant tube with the volume of 10mL, adding 0.01mmol of dichloro (pentamethylcyclopentadienyl) rhodium (III) dimer, 0.04mmol of silver hexafluoroantimonate, 0.2mmol of 2-phenylbenzothiazole, 0.3mmol of 3- (m-methyl) phenyl-1, 4, 2-bisoxazole-5-ketone, finally adding 2mL of dichloroethane, sealing, stirring and reacting at 120 ℃ for 24 hours, cooling to room temperature, detecting by TLC, completely transferring the reaction liquid into a round-bottom flask, adding a proper amount of 200-mesh and 300-mesh silica gel, distilling under reduced pressure to remove the organic solvent, performing silica gel column chromatography on the obtained crude product, elution was carried out using ethyl acetate and petroleum ether as eluents to give N- [2- (2-phenylbenzothiazole) ] - (m-methyl) benzamide (isolated yield 82%). The following are the nmr experimental data for the product:
1H NMR(400MHz,CDCl3)δ13.25(s,1H),9.04(d,J＝8.4Hz,1H),8.02-7.95(m,3H), 7.90-7.84(m,2H),7.52-7.38(m,5H),7.18-7.14(m,1H),2.52(s,3H)；13C NMR(100MHz, CDCl3)δ169.01,166.46,152.79,138.44,135.56,133.36,132.62,132.16,129.90,128.49,126.65, 125.82,124.92,123.20,122.20,121.55,120.90,119.35,21.60；HRMS(ESI):m/z[M+H]+calcd for C21H17N2OS+:345.1056；found:345.1060.
example 3
Putting a polytetrafluoroethylene magnet into a 10mL pressure resistant tube, adding 0.01mmol of dichloro (pentamethylcyclopentadienyl) rhodium (III) dimer, 0.04mmol of silver hexafluoroantimonate, 0.2mmol of 2-phenylbenzothiazole, 0.3mmol of 3-heptane-1, 4, 2-bisoxazole-5-ketone, finally adding 2mL of dichloroethane, sealing, stirring and reacting at 120 ℃ for 24h, cooling to room temperature, detecting by TLC, completely transferring the reaction liquid into a round-bottomed flask, adding a proper amount of 200-mesh 300-mesh silica gel, removing the organic solvent by reduced pressure distillation, and carrying out silica gel column chromatography on the obtained crude product and eluting by using ethyl acetate and petroleum ether as eluents to obtain N- [2- (2-phenylbenzothiazole) ] -heptylamide (the separation yield is 86%). The following are the nmr and mass spectroscopy experimental data for the product:
N-(2-(benzo[d]thiazol-2-yl)phenyl)octanamide(4f),white solid,yield 60.9mg(86％),Rf＝ 0.5(petroleum ether/EtOAc＝10:1).1H NMR(400MHz,CDCl3)δ12.40(s,1H),8.82(d,J＝8.4 Hz,1H),7.97(d,J＝8.0Hz,1H),7.89(d,J＝8.0Hz,1H),7.81(dd,J＝8.0,1.2Hz,1H),7.52-7.39 (m,3H),7.13-7.09(m,1H),2.53(t,J＝7.6Hz,2H),1.89-1.80(m,2H),1.46-1.25(m,9H), 0.88-0.84(m,3H)；13C NMR(100MHz,CDCl3)δ172.58,168.80,152.85,138.18,133.34,131.99, 129.81,126.57,125.76,122.95,122.51,121.47,120.86,118.92,39.00,31.73,29.34,29.11,25.70, 22.64,14.08；HRMS(ESI):m/z[M+H]+calcd for C21H25N2OS+:353.1682；found:353.1693.
example 4
Putting a polytetrafluoroethylene magnet into a pressure-resistant tube with the volume of 10mL, adding 0.01mmol of dichloro (pentamethylcyclopentadienyl) rhodium (III) dimer, 0.04mmol of silver hexafluoroantimonate, 0.2mmol of 2- (2-methylphenyl) benzothiazole, 0.3mmol of 3-phenyl-1, 4, 2-bisoxazole-5-ketone, finally adding 2mL of dichloroethane, sealing, stirring and reacting at 120 ℃ for 24 hours, cooling to room temperature, detecting the reaction by TLC, completely transferring the reaction liquid into a round-bottom flask, adding a proper amount of 200-mesh and 300-mesh silica gel, distilling under reduced pressure to remove the organic solvent, performing silica gel column chromatography on the obtained crude product, elution with ethyl acetate and petroleum ether as eluent gave N- [2- (2-methylphenyl) benzothiazole ] -benzamide (isolated yield 70%). The following are the nmr and mass spectroscopy experimental data for the product:
1H NMR(400MHz,CDCl3)δ11.34(s,1H),8.59(d,J＝8.4Hz,1H),8.13(d,J＝8.0Hz,1H), 7.94(d,J＝8.0Hz,1H),7.89-7.87(m,2H)7.58-7.54(m,1H),7.48-7.40(m,5H),7.11(d,J＝7.6 Hz,1H),2.62(s,3H)；13C NMR(100MHz,CDCl3)δ165.76,165.30,151.86,137.31,137.30, 135.36,135.20,131.73,130.86,128.62,127.30,126.84,126.67,125.80,122.64,122.19,121.53, 119.69,22.75；HRMS(ESI):m/z[M+H]+calcd for C21H17N2OS+:345.1056；found:345.1049.
example 5
Putting a polytetrafluoroethylene magnet into a pressure-resistant tube with the volume of 10mL, adding 0.01mmol of dichloro (pentamethylcyclopentadienyl) rhodium (III) dimer, 0.04mmol of silver hexafluoroantimonate, 0.2mmol of 2- (3-methylphenyl) benzothiazole, 0.3mmol of 3-phenyl-1, 4, 2-bisoxazole-5-ketone, finally adding 2mL of dichloroethane, sealing, stirring and reacting at 120 ℃ for 24 hours, cooling to room temperature, detecting the reaction by TLC, completely transferring the reaction liquid into a round-bottom flask, adding a proper amount of 200-mesh and 300-mesh silica gel, distilling under reduced pressure to remove the organic solvent, performing silica gel column chromatography on the obtained crude product, elution with ethyl acetate and petroleum ether as eluent gave N- [2- (3-methylphenyl) benzothiazole ] -benzamide (isolated yield 81%). The following are the nmr and mass spectroscopy experimental data for the product:
1H NMR(400MHz,CDCl3)δ13.14(s,1H),8.86(d,J＝8.4Hz,1H),8.16-8.14(m,2H),7.83 (d,J＝8.0Hz,1H),7.77(d,J＝8.0Hz,1H),7.55-7.52(m,4H),7.42(t,J＝7.6Hz,1H),7.32(t,J ＝7.6Hz,1H),7.24(d,J＝8.4Hz,1H),2.33(s,3H)；13C NMR(100MHz,CDCl3)δ168.92, 165.89,152.63,136.07,135.60,133.24,132.90,132.68,131.70,129.99,128.57,127.75,126.57, 125.68,122.04,121.44,120.74,119.06,20.82；HRMS(ESI):m/z[M+H]+calcd for C21H17N2OS+: 345.1056；found:345.1053.
example 6
Putting a polytetrafluoroethylene magnet into a pressure-resistant tube with the volume of 10mL, adding 0.01mmol of dichloro (pentamethylcyclopentadienyl) rhodium (III) dimer, 0.04mmol of silver hexafluoroantimonate, 0.2mmol of 2- (2-methoxyphenyl) benzothiazole, 0.3mmol of 3-phenyl-1, 4, 2-bisoxazole-5-ketone, finally adding 2mL of dichloroethane, sealing, stirring and reacting at 120 ℃ for 24 hours, cooling to room temperature, detecting the reaction by TLC, completely transferring the reaction liquid into a round-bottom flask, adding a proper amount of 200-mesh and 300-mesh silica gel, distilling under reduced pressure to remove the organic solvent, performing silica gel column chromatography on the obtained crude product, elution with ethyl acetate and petroleum ether as eluent gave N- [2- (2-methoxyphenyl) benzothiazole ] -benzamide (isolated 92% yield). The following are the nmr and mass spectroscopy experimental data for the product:
1H NMR(400MHz,CDCl3)δ14.37(s,1H),8.71(d,J＝8.4Hz,1H),8.20-8.18(m,2H), 7.84-7.79(m,2H),7.60-7.54(m,3H),7.43-7,29(m,3H),6.69(d,J＝8.4Hz,1H),3.95(s,3H)；13C NMR(100MHz,CDCl3)δ166.52,163.88,158.00,149.73,140.37,136.08,134.19,132.01,131.74, 128.58,127.95,126.09,125.10,121.32,120.86,113.45,109.25,105.71,55.67；HRMS(ESI):m/z [M+H]+calcd for C21H17N2O2S+:361.1005；found:361.0989.
example 7
Putting a polytetrafluoroethylene magnet into a pressure-resistant tube with the volume of 10mL, adding 0.01mmol of dichloro (pentamethylcyclopentadienyl) rhodium (III) dimer, 0.04mmol of silver hexafluoroantimonate, 0.2mmol of 5-chloro-2-phenylbenzothiazole, 0.3mmol of 3-phenyl-1, 4, 2-bisoxazole-5-ketone, finally adding 2mL of dichloroethane, sealing, stirring and reacting at 120 ℃ for 24 hours, cooling to room temperature, detecting by TLC, completely transferring the reaction liquid into a round-bottom flask, adding a proper amount of 200-mesh and 300-mesh silica gel, distilling under reduced pressure to remove the organic solvent, performing silica gel column chromatography on the obtained crude product, elution with ethyl acetate and petroleum ether as eluent gave N- [ 5-chloro-2-phenylbenzothiazole ] -benzamide (isolated yield 79%). The following are the nmr and mass spectroscopy experimental data for the product:
1H NMR(400MHz,CDCl3)δ13.13(s,1H),9.02(d,J＝8.4Hz,1H),8.17(d,J＝6.8Hz, 2H),7.85-7.81(m,3H),7.61-7.44(m,5H),7.16(t,J＝7.6Hz,1H)；13C NMR(100MHz,CDCl3)δ 169.47,166.19,151.24,138.45,135.52,134.50,132.52,131.96,131.83,129.84,128.68,127.74, 127.55,123.32,122.84,121.20,120.90,118.92,29.73；HRMS(ESI):m/z[M+H]+calcd for C20H14ClN2OS+:365.0510；found:365.0513.
example 8
Putting a polytetrafluoroethylene magnet into a pressure-resistant tube with the volume of 10mL, adding 0.01mmol of dichloro (pentamethylcyclopentadienyl) rhodium (III) dimer, 0.04mmol of silver hexafluoroantimonate, 0.2mmol of 5-fluoro-2- (2-methoxyphenyl) benzothiazole, 0.3mmol of 3-phenyl-1, 4, 2-bisoxazole-5-ketone, finally adding 2mL of dichloroethane, sealing, stirring at 120 ℃ for reaction for 24 hours, cooling to room temperature, detecting the reaction by TLC, completely transferring the reaction liquid into a round-bottom flask, adding a proper amount of 200-mesh and 300-mesh silica gel, distilling under reduced pressure to remove the organic solvent, performing silica gel column chromatography on the obtained crude product, elution with ethyl acetate and petroleum ether as eluent gave N- [ 5-fluoro-2- (2-methoxyphenyl) benzothiazole ] -benzamide (84% isolated yield). The following are the nmr and mass spectroscopy experimental data for the product:
1H NMR(400MHz,CDCl3)δ14.22(s,1H),8.73(d,J＝8.4Hz,1H),8.18-8.16(m,2H),7.79 (dd,J＝8.8,4.4Hz,1H),7.61-7.49(m,4H),7.43(t,J＝8.4Hz,1H),7.20-7.15(m,1H),6.75(d,J ＝8.0Hz,1H),4.01(s,3H)；13C NMR(100MHz,CDCl3)δ166.50,163.80,162.70(d,1JCF＝244.3 Hz),159.18,157.87,146.38,140.21,136.05,135.36(d,3JCF＝10.8Hz),132.19,131.82,128.60, 127.86,122.36(d,3JCF＝9.3Hz),114.91(d,2JCF＝24.9Hz),113.47,109.01,106.92(d,2JCF＝26.3 Hz),105.68,55.74；HRMS(ESI):m/z[M+H]+calcd for C21H16FN2O2S+:379.0911；found: 379.0905.
example 9
Putting a polytetrafluoroethylene magnet into a pressure-resistant tube with the volume of 10mL, adding 0.01mmol of dichloro (pentamethylcyclopentadienyl) rhodium (III) dimer, 0.04mmol of silver hexafluoroantimonate, 0.2mmol of 5-methyl-2- (2-methoxyphenyl) benzothiazole, 0.3mmol of 3-phenyl-1, 4, 2-bisoxazole-5-ketone, finally adding 2mL of dichloroethane, sealing, stirring at 120 ℃ for reaction for 24 hours, cooling to room temperature, detecting the reaction by TLC, completely transferring the reaction liquid into a round-bottomed flask, adding a proper amount of 200-mesh and 300-mesh silica gel, distilling under reduced pressure to remove the organic solvent, performing silica gel column chromatography on the obtained crude product, elution with ethyl acetate and petroleum ether as eluent gave N- [ 5-methyl-2- (2-methoxyphenyl) benzothiazole ] -benzamide (isolated yield 82%). The following are the nmr and mass spectroscopy experimental data for the product:
1H NMR(400MHz,CDCl3)δ14.37(s,1H),8.75(d,J＝8.4Hz,1H),8.23-8.22(m,2H),7.72 (d,J＝8.0Hz,1H),7.60-7.57(m,4H),7.39(t,J＝8.4Hz,1H),7.22(d,J＝8.0Hz,1H),6.71(d,J ＝8.0Hz,1H),3.96(s,3H),2.45(s,3H)；13C NMR(100MHz,CDCl3)δ166.40,162.79,157.83, 147.85,140.25,136.07,135.20,134.38,131.65,128.50,127.95,127.70,120.79,120.43,113.40, 109.34,105.67,55.60,21.62.HRMS(ESI):m/z[M+H]+calcd for C22H19N2O2S+:375.1162； found:375.1158.
example 10
Putting a polytetrafluoroethylene magnet into a pressure-resistant tube with the volume of 10mL, adding 0.01mmol of dichloro (pentamethylcyclopentadienyl) rhodium (III) dimer, 0.04mmol of silver hexafluoroantimonate, 0.2mmol of 2-phenylbenzothiazole, 0.3mmol of 3- (p-methyl) phenyl-1, 4, 2-bisoxazole-5-ketone, finally adding 2mL of dichloroethane, sealing, stirring and reacting at 120 ℃ for 24 hours, cooling to room temperature, detecting by TLC, completely transferring the reaction liquid into a round-bottom flask, adding a proper amount of 200-mesh and 300-mesh silica gel, distilling under reduced pressure to remove the organic solvent, performing silica gel column chromatography on the obtained crude product, elution was carried out using ethyl acetate and petroleum ether as eluents to give N- [2- (2-phenylbenzothiazole) ] - (p-methyl) benzamide (isolated yield 71%). The following are the nmr and mass spectroscopy experimental data for the product:
N-(2-(benzo[d]thiazol-2-yl)phenyl)-4-methylbenzamide(4d),white solid,yield 48.9mg (71％),Rf＝0.5(petroleum ether/EtOAc＝10:1).1H NMR(400MHz,CDCl3)δ13.28(s,1H), 9.04(d,J＝8.4Hz,1H),8.13(d,J＝8.0Hz,2H),8.00(d,J＝8.0Hz,1H),7.92-7.87(m,2H), 7.55-7.50(m,2H),7.44-7.37(m,3H),7.17(t,J＝7.6Hz,1H),2.48(s,3H)；13C NMR(100MHz, CDCl3)δ169.06,166.26,152.81,142.35,138.60,133.38,132.81,132.17,129.88,129.32,127.85, 126.70,125.83,123.10,122.24,121.54,120.87,119.31,21.55.HRMS(ESI):m/z[M+H]+calcd for C21H17N2OS+:345.1056；found:345.1051.
Claims (5)
1. a method for synthesizing N- [2- (2-aryl benzothiazole) ] -amide by rhodium catalysis is characterized in that: taking dichloro (pentamethylcyclopentadienyl) rhodium (III) dimer as a catalyst, silver hexafluoroantimonate as an additive, and 2-arylbenzothiazole and 1,4, 2-bisoxazole-5-ketone as reactants, and reacting in a DCE solvent to prepare N- [2- (2-arylbenzothiazole) ] -amide; the structural general formulas of the 1,4, 2-bisoxazole-5-ketone and the 2-aryl benzothiazole are respectively as follows:
wherein R is1Selected from alkyl, cycloalkyl, alkenyl, aryl, substituted aryl; r2Selected from hydrogen, alkyl, halogen; r3Selected from hydrogen, alkyl, hydroxyl, nitro, halogen, alkoxy and amino.
The specific reaction equation is shown below.
2. A rhodium-catalyzed process for the synthesis of N- [2- (2-arylbenzothiazole) ] -amides as set forth in claim 1 wherein: 1,4, 2-bisoxazol-5-one is represented by any one of the following formulae 1 to 14, and 2-arylbenzothiazole is represented by any one of the following formulae 15 to 43.
3. A rhodium-catalyzed process for the synthesis of N- [2- (2-arylbenzothiazole) ] -amides as claimed in claim 1 or 2 wherein: the 1,4, 2-bisoxazol-5-one is 3-phenyl-1, 4, 2-bisoxazol-5-one and the 2-arylbenzothiazole is 2-phenylbenzothiazole.
4. A rhodium-catalyzed process for the synthesis of N- [2- (2-arylbenzothiazole) ] -amides as claimed in claim 1 or 2 wherein: the molar ratio of dichloro (pentamethylcyclopentadienyl) rhodium (III) dimer, silver hexafluoroantimonate, 2-phenylbenzothiazole and 3-phenyl-1, 4, 2-bisoxazol-5-one was 0.05:0.2:1: 1.5.
5. A rhodium-catalyzed process for the synthesis of N- [2- (2-arylbenzothiazole) ] -amides of claim 4 wherein: the method comprises the following specific steps: adding dichloro (pentamethylcyclopentadienyl) rhodium (III) dimer, silver hexafluoroantimonate, 2-phenylbenzothiazole, 3-phenyl-1, 4, 2-bisoxazole-5-ketone and dichloroethane into a pressure-resistant tube according to the proportion in claim 4, adding a polytetrafluoroethylene magnet particle, sealing, stirring at 120 ℃ for reaction for 24 hours, cooling to room temperature, detecting by TLC to finish the reaction, completely transferring the reaction liquid into a round-bottomed flask, adding a proper amount of 200-mesh 300-mesh silica gel, distilling under reduced pressure to remove the organic solvent, carrying out silica gel column chromatography on the obtained crude product, and eluting by using ethyl acetate and petroleum ether as eluents to obtain N- [2- (2-arylbenzothiazole) ] -amide.
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| CN106632086A (en) * | 2016-12-30 | 2017-05-10 | 江西省林业科学院 | 2-(2-iodoaryl)quinazoline compound and preparation method thereof |
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| CN106632086A (en) * | 2016-12-30 | 2017-05-10 | 江西省林业科学院 | 2-(2-iodoaryl)quinazoline compound and preparation method thereof |
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| Title |
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| Mechanochemical Rhodium(III)-Catalyzed C-H Bond Amidation of Arenes with Dioxazolones under Solventless Conditions in a Ball Mill;Gary N.Hermann等;《ACS Catalysis》;20170605;第7卷;第4592-4596页 * |
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