CN108239084A - The process units of neuritis medicine thiamine hydrochloride - Google Patents
The process units of neuritis medicine thiamine hydrochloride Download PDFInfo
- Publication number
- CN108239084A CN108239084A CN201711293270.6A CN201711293270A CN108239084A CN 108239084 A CN108239084 A CN 108239084A CN 201711293270 A CN201711293270 A CN 201711293270A CN 108239084 A CN108239084 A CN 108239084A
- Authority
- CN
- China
- Prior art keywords
- reaction kettle
- storage tank
- process units
- transmission pump
- thiamine hydrochloride
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The process units of neuritis medicine thiamine hydrochloride, mainly includes：Storage tank (F101), storage tank (F102), reaction kettle (D101), condenser (C101), transmission pump (J101), storage tank (F103), reaction kettle (D102), transmission pump (J102), storage tank (F104), reaction kettle (D103), wherein, transmission pump (J101) is connected respectively with reaction kettle (D101), reaction kettle (D102), transmission pump (J102) is connected respectively with reaction kettle (D102), reaction kettle (D103), wherein, 2.6 2.8m of storage tank (F102) total volume3。
Description
Technical field
The present invention relates to compound synthesis device more particularly to the process units of neuritis medicine thiamine hydrochloride.
Background technology
Thiamine hydrochloride is for auxiliary treatments such as peripheral neuritis, myocarditis, indigestion, congestive heart failures；For
The supplement of vitamin B1：Including burning, generating heat, long-term chronic infected patient；Malabsorption syndrome companion hepatobiliary system disease is (such as
Alcoholism is with hepatic sclerosis), disease of intestine (such as chylous diarrhea, persistent diarrhea), after gastrectomy, hyperthyroidism and into
The patient of row haemodialysis；Malnutrition caused by long-time parenteral nutrition or insufficiency of intake, heavy worker and pregnant woman,
Women breast-feeding their children.Existing process units is mostly more complicated, and for thiamine hydrochloride as neuritis medicine, process units is excellent
It is bad for improve product quality, reduce by-products content have Important Economic meaning.
Invention content
The purpose of the present invention is to provide the process units of neuritis medicine thiamine hydrochloride, mainly include：Storage tank
(F101), storage tank (F102), reaction kettle (D101), condenser (C101), transmission pump (J101), storage tank (F103), reaction kettle
(D102), transmission pump (J102), storage tank (F104), reaction kettle (D103), wherein, transmission pump (J101) respectively with reaction kettle
(D101), reaction kettle (D102) is connected, and transmission pump (J102) is connected respectively with reaction kettle (D102), reaction kettle (D103),
Wherein, storage tank (F102) total volume 2.6-2.8m3, condenser (C101) heat exchange tube diameter 0.013-0.014m, reaction kettle
(D102) interior pot diameter 800-900mm.
The process units of neuritis medicine thiamine hydrochloride, production procedure are：By ethenylamidine hydrochloride and alpha, alpha-dimethyl oxygroup first
Base-'beta '-methoxy methyl propionitrile is added in reaction kettle D101, and it is 3,6- dimethyl 1 to be condensed in alkaline intermediary, 2- dihydros -2,4,
5, the 7- petrins (II) then obtain intermediate product (III) through hydrolysis, then in alkalinity closed loop into 2- methyl 4- amino -5- ammonia first
Yl pyrimidines (IV) are imported in D102, continue to act on obtaining (V) with carbon disulfide and ammonium hydroxide, then with acetic acid-γ-chloro-γ
Propyl acetate is condensed and then hydrolysis and cyclization obtain thiothiamine hydrochloride in hydrochloric acid, D103 is pumped into, in ammonium hydroxide
With after hydrogen peroxide oxidation, then ammonium nitrate thiamines is converted into nitric acid, finally plus hydrochloric acid obtains product.Advantage of the present invention exists
In：Reduce reaction intermediate link, reduce reaction temperature and reaction time, improve reaction yield.
Description of the drawings
Fig. 1 is the process units of neuritis medicine thiamine hydrochloride, is mainly included：Storage tank (F101), storage tank (F102),
Reaction kettle (D101), condenser (C101), transmission pump (J101), storage tank (F103), reaction kettle (D102), transmission pump (J102),
Storage tank (F104), reaction kettle (D103).
Specific embodiment
With reference to specific implementation example, the invention will be further described：
Example 1：
Raw materials for production and dosage
The process units of neuritis medicine thiamine hydrochloride, mainly includes：Storage tank (F101), storage tank (F102), reaction
Kettle (D101), condenser (C101), transmission pump (J101), storage tank (F103), reaction kettle (D102), transmission pump (J102), storage tank
(F104), reaction kettle (D103), wherein, transmission pump (J101) is connected respectively with reaction kettle (D101), reaction kettle (D102), passes
Pump (J102) is sent to be connected respectively with reaction kettle (D102), reaction kettle (D103), wherein, storage tank (F102) total volume 2.6m3, it is cold
Condenser (C101) heat exchange tube diameter 0.013m, the interior pot diameter 800mm of reaction kettle (D102).
The process units of neuritis medicine thiamine hydrochloride, production procedure are：By ethenylamidine hydrochloride and alpha, alpha-dimethyl oxygroup first
Base-'beta '-methoxy methyl propionitrile is added in reaction kettle D101, and it is 3,6- dimethyl 1 to be condensed in alkaline intermediary, 2- dihydros -2,4,
5, the 7- petrins (II) then obtain intermediate product (III) through hydrolysis, then in alkalinity closed loop into 2- methyl 4- amino -5- ammonia first
Yl pyrimidines (IV) are imported in D102, continue to act on obtaining (V) with carbon disulfide and ammonium hydroxide, then with acetic acid-γ-chloro-γ
Propyl acetate is condensed and then hydrolysis and cyclization obtain thiothiamine hydrochloride in hydrochloric acid, D103 is pumped into, in ammonium hydroxide
With after hydrogen peroxide oxidation, then ammonium nitrate thiamines is converted into nitric acid, finally plus hydrochloric acid obtains product.
Product quality
Example 2：
Raw materials for production and dosage
The process units of neuritis medicine thiamine hydrochloride, mainly includes：Storage tank (F101), storage tank (F102), reaction
Kettle (D101), condenser (C101), transmission pump (J101), storage tank (F103), reaction kettle (D102), transmission pump (J102), storage tank
(F104), reaction kettle (D103), wherein, transmission pump (J101) is connected respectively with reaction kettle (D101), reaction kettle (D102), passes
Pump (J102) is sent to be connected respectively with reaction kettle (D102), reaction kettle (D103), wherein, storage tank (F102) total volume 2.8m3, it is cold
Condenser (C101) heat exchange tube diameter 0.014m, the interior pot diameter 900mm of reaction kettle (D102).
The process units of neuritis medicine thiamine hydrochloride, production procedure are：By ethenylamidine hydrochloride and alpha, alpha-dimethyl oxygroup first
Base-'beta '-methoxy methyl propionitrile is added in reaction kettle D101, and it is 3,6- dimethyl 1 to be condensed in alkaline intermediary, 2- dihydros -2,4,
5, the 7- petrins (II) then obtain intermediate product (III) through hydrolysis, then in alkalinity closed loop into 2- methyl 4- amino -5- ammonia first
Yl pyrimidines (IV) are imported in D102, continue to act on obtaining (V) with carbon disulfide and ammonium hydroxide, then with acetic acid-γ-chloro-γ
Propyl acetate is condensed and then hydrolysis and cyclization obtain thiothiamine hydrochloride in hydrochloric acid, D103 is pumped into, in ammonium hydroxide
With after hydrogen peroxide oxidation, then ammonium nitrate thiamines is converted into nitric acid, finally plus hydrochloric acid obtains product.
Product quality
It described in above example, is merely preferred embodiments of the present invention, but protection scope of the present invention not office
Be limited to this, any one skilled in the art in the technical scope disclosed by the present invention, the technique according to the invention
Scheme and its inventive concept are subject to equivalent substitution or change, should be covered by the protection scope of the present invention.
Claims (3)
1. the process units of neuritis medicine thiamine hydrochloride, which is characterized in that mainly include：Storage tank (F101), storage tank
(F102), reaction kettle (D101), condenser (C101), transmission pump (J101), storage tank (F103), reaction kettle (D102), transmission pump
(J102), storage tank (F104), reaction kettle (D103), wherein, transmission pump (J101) respectively with reaction kettle (D101), reaction kettle
(D102) it is connected, transmission pump (J102) is connected respectively with reaction kettle (D102), reaction kettle (D103), wherein, storage tank
(F102) total volume 2.6-2.8m3。
2. the process units of neuritis medicine thiamine hydrochloride according to claim 1, which is characterized in that the condensation
Device (C101) heat exchange tube diameter 0.013-0.014m.
3. the process units of neuritis medicine thiamine hydrochloride according to claim 1, which is characterized in that the reaction
The interior pot diameter 800-900mm of kettle (D102).
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711293270.6A CN108239084A (en) | 2017-12-08 | 2017-12-08 | The process units of neuritis medicine thiamine hydrochloride |
| GBGB1722019.5A GB201722019D0 (en) | 2017-12-08 | 2017-12-28 | Neuritis treatment drug thiamine hydrochloride production plant |
| AU2018101877A AU2018101877A4 (en) | 2017-12-08 | 2018-11-30 | Neuritis treatment drug thiamine hydrochloride production plant |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711293270.6A CN108239084A (en) | 2017-12-08 | 2017-12-08 | The process units of neuritis medicine thiamine hydrochloride |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108239084A true CN108239084A (en) | 2018-07-03 |
Family
ID=61158061
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711293270.6A Withdrawn CN108239084A (en) | 2017-12-08 | 2017-12-08 | The process units of neuritis medicine thiamine hydrochloride |
Country Status (3)
| Country | Link |
|---|---|
| CN (1) | CN108239084A (en) |
| AU (1) | AU2018101877A4 (en) |
| GB (1) | GB201722019D0 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116283952A (en) * | 2022-09-09 | 2023-06-23 | 复旦大学 | Vitamin B 1 Is a fully continuous flow preparation method |
-
2017
- 2017-12-08 CN CN201711293270.6A patent/CN108239084A/en not_active Withdrawn
- 2017-12-28 GB GBGB1722019.5A patent/GB201722019D0/en not_active Ceased
-
2018
- 2018-11-30 AU AU2018101877A patent/AU2018101877A4/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU2018101877A4 (en) | 2019-01-24 |
| GB201722019D0 (en) | 2018-02-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108239084A (en) | The process units of neuritis medicine thiamine hydrochloride | |
| CN105440035B (en) | A kind of low energy consumption synthesizes high-purity folic acid preparation method | |
| CN102351795A (en) | Edaravone compound with stable crystal form | |
| CN105712984A (en) | Preparation method of Azilsartan | |
| CN101139280B (en) | Preparation method of sodium acetate anhydrous | |
| CN102241632A (en) | Preparation method of ozagrel bulk drug | |
| CN104447477B (en) | A kind of preparation method of Sulpiride | |
| CN106176585A (en) | A kind of preparation method of ornidazole injection | |
| IE20180523U1 (en) | Neuritis treatment drug thiamine hydrochloride production plant | |
| CN107011288A (en) | A kind of preparation method of aripiprazole intermediate 1 (2,3 dichlorophenyl) piperazine hydrochloride | |
| CN108236894A (en) | The process units of flocculating agent anhydrous slufuric acid ammonium aluminium | |
| CN111349098A (en) | Preparation method of sitagliptin intermediate | |
| CN105061327A (en) | Synthetic method of long-acting sulfonamide | |
| IES20180523A2 (en) | Neuritis treatment drug thiamine hydrochloride production plant | |
| CN104311550B (en) | Preparation method of 6-hydroxytropinone | |
| CN108236909A (en) | The process units of cationic softener ES | |
| CN108239533A (en) | The process units of CT1-6 acid liquor gellants | |
| AU2018101408A4 (en) | Zinc organic strengthener zinc α-hydroxypropionate production plant | |
| CN102603570B (en) | Preparation method for 2,3,4-trimethoxy benzonitrile | |
| CN107235873A (en) | A kind of preparation method of high-purity mesna | |
| CN108238849A (en) | The process units of antiseptic tert-butyl hydroquinone drug | |
| CN108239877A (en) | The process units of waterproofing agent stearoyl chromium chloride | |
| CN105017349B (en) | A kind of glycosyl indole derivatives and its preparation and application | |
| CN104086389A (en) | Synthetic method of ethyl vanillin | |
| CN108239462A (en) | The process units of urea-formaldehyde condensates coating |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20180703 |