CN108236619A - Creat extract and its extracting method - Google Patents
Creat extract and its extracting method Download PDFInfo
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- CN108236619A CN108236619A CN201611207510.1A CN201611207510A CN108236619A CN 108236619 A CN108236619 A CN 108236619A CN 201611207510 A CN201611207510 A CN 201611207510A CN 108236619 A CN108236619 A CN 108236619A
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- Prior art keywords
- extract
- creat
- creat extract
- mother liquor
- extracting solution
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The present invention provides a kind of creat extract extremely extracting method, it is characterised in that：Include the following steps, S1, Herba Andrographitis prophyll crosses 200 mesh, add in medicinal alcohol adverse current and extract, filtering obtains extracting solution through ultramicro grinding；S2, extracting solution is interior to add in activated carbon decolorizing, and filtering obtains filtrate；S3, filtrate decompression concentration, crystallization, separation obtain crystal crude product and mother liquor；Condensing crystallizing process carries out under the conditions of existing for nitrogen；S4, mother liquor are concentrated under reduced pressure, and obtain solid-like creat extract.Creat extract is obtained using said extracted method.Herba Andrographitis raw material leaf ultramicro grinding can improve disengaging for effective ingredient into 200 mesh, and then improve the yield of creat extract.Edible ethanol and methanol is replaced to reduce ill-effect of the nuisance residual to human body with medicinal alcohol.Nitrogen is added in filtrate decompression concentration process, the generation that can reduce oxide in heating process not only improves product purity, also in a disguised form improves product yield.
Description
Technical field
Extracting method and thus obtained creat extract the present invention relates to creat extract.
Background technology
Creat extract acanthaceous plant Herba Andrographitis (circular cone palpus medicinal herbs) Andrographis paniculata
(Burm.f.) the processed extraction drying of the dry aerial parts of Nees is made, and is the addition product for producing creat lactone in itself,
Its ingredient is mainly remaining extract (the total lactones of Herba Andrographitis) in addition to creat lactone ingredient, has clearing heat and detoxicating, and cool blood disappears
The effect of swollen.At present to the extraction of creat extract mostly using edible ethanol or methanol, extracted, filtering, crystallization, divides at decoloration
From, be concentrated to give, but edible ethanol and methanol in process of production to human body there is a great harm for, particularly methanol, hazardous solvent
Residual play non-controllable risk to people's drug safety, and the yield of creat extract in the prior art is relatively low.Therefore, such as
Where reduce the presence of hazardous solvent in creat extract, improve drug safety, and improve the yield of product, becoming each producer will
It solves the problems, such as.
Invention content
It is an object of the present invention to provide a kind of creat extract extracting methods, it is therefore an objective to prior art problem is solved,
A kind of residual that can both reduce hazardous solvent is provided, improves drug safety, while improve the extracting method of product yield.
Second object of the present invention is to provide a kind of creat extract obtained using said extracted method.
It is of the present invention solve the problems, such as the technical solution adopted is that：
Creat extract extracting method, includes the following steps,
S1, Herba Andrographitis prophyll cross the sieve not less than 200 mesh through ultramicro grinding, add in medicinal alcohol adverse current and extract, filtering,
Obtain extracting solution.
Herba Andrographitis effective ingredient can be improved to Herba Andrographitis raw material leaf progress 200 mesh of ultramicro grinding to disengage, and improve Herba Andrographitis
The yield of medicinal extract.
Edible ethanol and methanol is replaced to reduce ill-effect of the nuisance residual to human body with medicinal alcohol.
S2, extracting solution is interior to add in activated carbon decolorizing, and filtering obtains filtrate；
S3, filtrate decompression concentration, crystallization, separation obtain crystal crude product and mother liquor；It is concentrated under reduced pressure and crystallization process is deposited in nitrogen
It carries out under the conditions.Reduced pressure carries out in a heated condition, and oxidation reaction easily occurs, and generates oxide impurity.And by
In the presence of nitrogen, filtrate is made to reduce oxidation reaction in reduced pressure, reduce the generation of oxide impurity, not only reduce color
Number, and reduce the follow-up impurity brought into creat extract, creat extract finished product purity is improved, improves medication peace
Entirely.
S4, mother liquor are concentrated under reduced pressure, and obtain solid-like creat extract.
Further, in S2 steps, extracting solution is heated to constantly be slowly stirred in boiling process, decoloration.
Further, a concentration of 75%-95% of the medicinal alcohol.
Creat extract is obtained using said extracted method.
Beneficial effects of the present invention：
It is disengaged 1. carrying out ultramicro grinding to Herba Andrographitis raw material leaf and can effectively improve Herba Andrographitis effective ingredient into 200 mesh, into
And improve the yield of creat extract.
2. edible ethanol and methanol is replaced to reduce ill-effect of the nuisance residual to human body with medicinal alcohol.
3. filtrate decompression concentration process is heating reaction, nitrogen is added in heating reaction, can reduce in heating process and aoxidize
The generation of object.Oxide is a kind of impurity, harm is generated to human body, therefore reduce the generation of oxide, can not only reduce and wear
The content of oxide, improves drug safety in heart lotus medicinal extract, also reduces active principle and is transformed into oxide impurity, covert to improve
The yield of creat extract.
Specific embodiment
The present invention is described in further details below in conjunction with specific embodiment.
Embodiment 1
The extraction of creat extract：
S1 by Herba Andrographitis prophyll ultramicro grinding, crosses 200 mesh.It adds in 95% medicinal alcohol adverse current to extract, filtering is (with stainless
Steel plate carries out press filtration), the isolated dregs of a decoction, extracting solution.
S2, the interior activated carbon that adds in of extracting solution decolourize, and wherein extracting solution is heated to constantly be slowly stirred in boiling process,
Press filtration is carried out with stainless steel plate after decoloration, obtains filtrate.
Filtrate decompression is concentrated, crystallized by S3, is detached after standing 12 hours, isolated crystal crude product and mother liquor.Wherein subtract
Nitrogen is added in pressure concentration and crystallization process, in reative cell full of entire space, oxidation reaction can be reduced, reduce color number.It obtains
Crystal crude product for producing creat lactone, mother liquor is for producing creat extract.
S4, mother liquor are concentrated under reduced pressure, and being heated to boiling makes its dehydration, the final creat extract for obtaining solid-like.
Embodiment 2
The extraction of creat extract：
S1 by Herba Andrographitis prophyll ultramicro grinding, crosses 300 mesh.It adds in 75% medicinal alcohol adverse current to extract, filtering is (with stainless
Steel plate carries out press filtration), the isolated dregs of a decoction, extracting solution.
S2, the interior activated carbon that adds in of extracting solution decolourize, and wherein extracting solution is heated to constantly be slowly stirred in boiling process,
Press filtration is carried out with stainless steel plate after decoloration, obtains filtrate.
Filtrate decompression is concentrated, crystallized by S3, is detached after standing 12 hours, isolated crystal crude product and mother liquor.Wherein subtract
Nitrogen is added in pressure concentration and crystallization process, in reative cell full of entire space, oxidation reaction can be reduced, reduce color number.It obtains
Crystal crude product for producing creat lactone, mother liquor is for producing creat extract.
S4, mother liquor are concentrated under reduced pressure, and being heated to boiling makes its dehydration, the final creat extract for obtaining solid-like.
Embodiment 3
The extraction of creat extract：
S1 by Herba Andrographitis prophyll ultramicro grinding, crosses 200 mesh.It adds in 85% medicinal alcohol adverse current to extract, filtering is (with stainless
Steel plate carries out press filtration), the isolated dregs of a decoction, extracting solution.
S2, the interior activated carbon that adds in of extracting solution decolourize, and wherein extracting solution is heated to constantly be slowly stirred in boiling process,
Press filtration is carried out with stainless steel plate after decoloration, obtains filtrate.
Filtrate decompression is concentrated, crystallized by S3, is detached after standing 12 hours, isolated crystal crude product and mother liquor.Wherein subtract
Nitrogen is added in pressure concentration and crystallization process, in reative cell full of entire space, oxidation reaction can be reduced, reduce color number.It obtains
Crystal crude product for producing creat lactone, mother liquor is for producing creat extract.
S4, mother liquor are concentrated under reduced pressure, and being heated to boiling makes its dehydration, the final creat extract for obtaining solid-like.
Comparative example
The extraction of creat extract：
S1 crushes Herba Andrographitis prophyll, adds in 95% edible ethanol adverse current and extracts, filtering (is pressed with stainless steel plate
Filter), the isolated dregs of a decoction, extracting solution.
S2, the interior activated carbon that adds in of extracting solution decolourize, and wherein extracting solution is heated to constantly be slowly stirred in boiling process,
Press filtration is carried out with stainless steel plate after decoloration, obtains filtrate.
Filtrate decompression is concentrated, crystallized by S3, is detached after standing 12 hours, isolated crystal crude product and mother liquor.It obtains
For producing creat lactone, mother liquor is used to produce creat extract crystal crude product.
S4, mother liquor are concentrated under reduced pressure, and being heated to boiling makes its dehydration, the final creat extract for obtaining solid-like.
The comparison of the indices of creat extract in table 1 to be obtained in embodiment 1-3 and comparative example.
Table 1
No matter from table 1 it follows that by the creat extract that technique in embodiment 1 obtains from purity or yield
The creat extract obtained in upper better than comparative example.Since in filtrate decompression concentration and crystallization process, reaction is in nitrogen
In compression ring border, reduce the generation of oxide impurity, and extract and other impurities can be more detached in each link,
So the more original production technology of yield and purity of creat extract has promotion, the yield of creat extract improves 20%
More than.
Claims (4)
1. creat extract extracting method, it is characterised in that：Include the following steps,
S1, Herba Andrographitis prophyll are crossed and are sieved not less than 200 mesh, add in medicinal alcohol adverse current and extract, filtering must extract through ultramicro grinding
Liquid；
S2, extracting solution is interior to add in activated carbon decolorizing, and filtering obtains filtrate；
S3, filtrate decompression concentration, crystallization, separation obtain crystal crude product and mother liquor；It is concentrated under reduced pressure and crystallization process is existing for nitrogen
Under the conditions of carry out；
S4, mother liquor are concentrated under reduced pressure, and obtain solid-like creat extract.
2. creat extract extracting method as described in claim 1, it is characterised in that：In S2 steps, extracting solution is heated to
It is constantly slowly stirred, decolourizes in boiling process.
3. creat extract extracting method as described in claim 1, it is characterised in that：The medicinal alcohol is a concentration of
75%-95%.
4. creat extract is obtained using extracting method any in such as claim 1-3.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611207510.1A CN108236619A (en) | 2016-12-23 | 2016-12-23 | Creat extract and its extracting method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611207510.1A CN108236619A (en) | 2016-12-23 | 2016-12-23 | Creat extract and its extracting method |
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| Publication Number | Publication Date |
|---|---|
| CN108236619A true CN108236619A (en) | 2018-07-03 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611207510.1A Pending CN108236619A (en) | 2016-12-23 | 2016-12-23 | Creat extract and its extracting method |
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| CN (1) | CN108236619A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109985416A (en) * | 2019-03-01 | 2019-07-09 | 临泉县清华地产中药材有限责任公司 | A kind of device for refining of Herba Andrographitis |
Citations (2)
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|---|---|---|---|---|
| CN102382083A (en) * | 2010-09-01 | 2012-03-21 | 天津天士力现代中药资源有限公司 | Preparation method of andrographolide |
| CN103145660A (en) * | 2013-03-25 | 2013-06-12 | 成都天台山制药有限公司 | Andrographolide and preparation method thereof |
-
2016
- 2016-12-23 CN CN201611207510.1A patent/CN108236619A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102382083A (en) * | 2010-09-01 | 2012-03-21 | 天津天士力现代中药资源有限公司 | Preparation method of andrographolide |
| CN103145660A (en) * | 2013-03-25 | 2013-06-12 | 成都天台山制药有限公司 | Andrographolide and preparation method thereof |
Non-Patent Citations (6)
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| 中国生物器材网: "常用浓缩方法介绍", 《中国生物器材网》 * |
| 刘洪娜: "穿心莲超微粉有效成分溶出及药物代谢动力学研究", 《中国优秀硕士学位论文全文数据库》 * |
| 崔炎路等: "穿心莲内酯及穿心莲总内酯提取工艺的改进实验 ", 《中成药》 * |
| 王大林: "穿心莲母液浸膏片的试制研究", 《中成药研究》 * |
| 谢平: "《天然药物化学实验技术》", 31 December 1993, 江西科学技术出版社 * |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109985416A (en) * | 2019-03-01 | 2019-07-09 | 临泉县清华地产中药材有限责任公司 | A kind of device for refining of Herba Andrographitis |
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