CN108226140A - A kind of medicine preparation process on-line measuring device - Google Patents
A kind of medicine preparation process on-line measuring device Download PDFInfo
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- CN108226140A CN108226140A CN201810312086.XA CN201810312086A CN108226140A CN 108226140 A CN108226140 A CN 108226140A CN 201810312086 A CN201810312086 A CN 201810312086A CN 108226140 A CN108226140 A CN 108226140A
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- probe
- preparation process
- medicine preparation
- controller
- measuring device
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/65—Raman scattering
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- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Abstract
The present invention relates to a kind of medicine preparation process on-line measuring devices, including reaction kettle, injection device, Raman spectrum detection system and controller, injection device injection reaction raw material into reaction kettle, injection device includes injection-tube, injection-tube is connected separately with storing unit and syringe pump, for holding reaction raw materials, syringe pump is connect storing unit with controller；Raman spectrum detection system includes laser, fibre optical sensor and Raman spectrometer, Raman spectrometer connects the controller, fibre optical sensor is popped one's head in including a light scattering, light scattering probe includes the detector of probe and face probe, probe passes through input optical fibre connecting laser, detector receives the laser from probe and sends out scattering light, probe collection, which scatters light and passes through output optical fibre, passes to Raman spectrometer, controller receives the output signal of Raman spectrometer, the substrate and the nano-array positioned at substrate surface that detector includes plane, nano-array is made of multiple carbon nanotubes.
Description
Technical field
The present invention relates to medicine production process detection technique fields more particularly to a kind of medicine preparation process on-line checking to fill
It puts.
Background technology
At present, during pharmaceutical synthesis, reactant usually feeds manually, and there are certain errors for feeding quantity, it is possible to right
Subsequent reactions cause very big influence, and the general way of detection for reacting the product in each stage is sampled from reaction vessel, so
Carry out chromatography again afterwards, but longer the time required to chromatography, for the detection of unstable product, the timeliness of detection
Property it is most important, if place the long period detect again, significant change, the standard of testing result can occur for the concentration or structure of product
True property is difficult to be guaranteed.And Raman spectrum, as a kind of analysis method, with its abundant information, sample preparation is simple, and the interference of water is small
Deng uniqueness the advantages of, in chemistry, biology, medicine and other fields are widely used.A but master of Raman spectrometry application
Limiting is, the Raman scattering signal obtained from micro- trace chemical is very weak, reduces it and detects the scope of application, increases
Detection difficulty.
Invention content
In order to solve the above technical problems, the object of the present invention is to provide a kind of medicine preparation process on-line measuring device, it should
Device can be during pharmaceutical synthesis, intelligent control reactant feeding quantity, at the same to the chemical reaction situation in reaction kettle with
And new product carries out on-line checking, and the raman spectral signal intensity of product is greatly enhanced in detection process.
A kind of medicine preparation process on-line measuring device of the present invention, including reaction kettle, injection device, Raman spectrum detection
System and controller, injection device injection reaction raw material into the reaction kettle, the injection device include injection-tube,
The injection-tube is connected separately with storing unit and syringe pump, and the storing unit is used to hold reaction raw materials, the syringe pump
It is connect with the controller；The Raman spectrum detection system includes laser, fibre optical sensor and Raman spectrometer, described
Raman spectrometer connects the controller, and the fibre optical sensor is popped one's head in including a light scattering, and the light scattering probe includes visiting
The detector popped one's head in described in head and face, the probe connect the laser by input optical fibre, and the detector, which receives, to be come
From the laser of probe and scattering light is sent out, light is scattered described in the probe collection and passes through output optical fibre passes to the Raman light
Spectrometer, the controller receive the output signal of the Raman spectrometer, and the detector includes the substrate of plane and is located at
The nano-array of the substrate surface, the nano-array are made of multiple carbon nanotubes.
Further, the reaction kettle includes autoclave body, and the autoclave body is connected with heating unit, and the heating unit includes adding
Hot component and multiple temperature sensors, the temperature sensor connect the controller.
Further, agitating unit is also associated in the reaction kettle, the stirrer paddle of the agitating unit is positioned at described
Autoclave body bottom.The setting of agitating unit, can either improve the uniformity of reaction mass mixing, and can prevent reactant and autoclave body
The bonding of inner wall, convenient for after reaction to the cleaning of autoclave body.
Further, the heating component is looped around in the shape of a spiral outside the autoclave body.
Further, heat transfer medium is equipped between the autoclave body and heating component, the heating component passes through the heat transfer
The autoclave body heating is connected between medium.
Further, multiple temperature sensors are arranged on the inner wall of the autoclave body, and multiple temperature sensor edges
The uniformly arrangement at equal intervals from top to bottom of the inner wall of the autoclave body.Autoclave body connects heating unit, and heating unit includes a temperature sensing
Device can monitor the temperature inside reaction kettle in real time.
Further, distance of the carbon nanotube top apart from the upper surface of substrate is 50nm-200nm.
Further, the focusing of multiple scattered light signals for being used to enhance detector is equipped between the probe and detector
Mirror.
Further, the shape of the carbon nanotube is tapered or cylindrical.
Further, the syringe pump is connected with flow controlling unit, and the syringe pump passes through the flow controlling unit
It is connect with the controller.
According to the above aspect of the present invention, the present invention has at least the following advantages：
By setting injection device, the automation to feed in reaction process can be realized, reduce the error artificially to feed；
The nano-array on detector base surface, nano-array are made of multiple tapered carbon nanotubes, and the setting of carbon nanotube carries
The high intensity of the Raman scattering light signal of detector reflection, and it is transferred to probe so that detection process is more efficient, quickly,
Accuracy rate is high.
Above description is only the general introduction of technical solution of the present invention, in order to better understand the technological means of the present invention,
And can be implemented in accordance with the contents of the specification, below with presently preferred embodiments of the present invention and after attached drawing is coordinated to be described in detail such as.
Description of the drawings
Fig. 1 is the structure diagram of reaction kettle and injection device of the present invention；
Fig. 2 is reaction kettle cross-sectional view of the present invention；
Fig. 3 is the structure diagram of Raman spectrum detection system of the present invention；
Reference sign：
1- autoclave bodies；2- heat transfer mediums；3- heating components；4- injection-tubes；5- storing units；6- controllers；7- syringe pumps；8-
Temperature sensor；9- stirrer paddles；10- lasers；11- input optical fibres；12- output optical fibres；13- Raman spectrometers；14- carbon is received
Mitron；15- substrates；16- pops one's head in；17- focus lamps.
Specific embodiment
With reference to the accompanying drawings and examples, the specific embodiment of the present invention is described in further detail.Implement below
Example is used to illustrate the present invention, but be not limited to the scope of the present invention.
Embodiment 1
Referring to Fig. 1-3, a kind of medicine preparation process on-line measuring device of the invention, including reaction kettle, injection device, drawing
Graceful spectral detection system and controller.
Reaction kettle includes autoclave body 1, and the autoclave body 1 is connected with heating unit, and the heating unit includes heating component 3 and more
A temperature sensor 8, the temperature sensor 8 connect the controller 6.Multiple temperature sensors 8 are arranged on the kettle
On the inner wall of body 1, and inner wall from top to bottom at equal intervals uniformly arrangement of the multiple temperature sensors 8 along the autoclave body.Heating component 3
It is looped around in the shape of a spiral outside the autoclave body 1.Heat transfer medium 2 is equipped between autoclave body 1 and heating component 3, the heating component 3 is logical
It crosses between the heat transfer medium 2 and is connected in the autoclave body 1 and heats.
Agitating unit is also associated in reaction kettle, the stirrer paddle 9 of agitating unit is located at 1 bottom of autoclave body.Stirring is single
The setting of member, can either improve the uniformity of reaction mass mixing, and can prevent the bonding of reactant and inner wall of kettle, be convenient for
After reaction to the cleaning of autoclave body.
Injection device injection reaction raw material into the reaction kettle, the injection device include injection-tube 4, the injection-tube
4 are connected separately with storing unit 5 and syringe pump 7, the storing unit 5 for holding reaction raw materials, the syringe pump 7 with it is described
Controller 6 connects.Syringe pump 7 is connected with flow controlling unit, and the syringe pump 7 passes through the flow controlling unit and the control
Device 6 processed connects.
Raman spectrum detection system includes laser 10, fibre optical sensor and Raman spectrometer 13, the Raman spectrum
Instrument 13 connects the controller 6, and the fibre optical sensor is popped one's head in including a light scattering, and the light scattering probe includes 16 Hes of popping one's head in
The detector of probe 16 described in face is equipped with multiple scattered light signals for being used to enhance detector between probe 16 and detector
Focus lamp 17.The probe 16 connects the laser 10 by input optical fibre 11, and the detector is received from probe 16
Laser simultaneously sends out scattering light, and the probe 16, which collects the scattering light and passes through output optical fibre 12, passes to the Raman spectrometer
13, the controller 6 receives the output signal of the Raman spectrometer 13, and the detector includes substrate 15 and the position of plane
Nano-array in 15 surface of substrate, the nano-array are made of multiple carbon nanotubes 14, the shape of carbon nanotube 14
Tapered or cylindrical, distance of 14 top of carbon nanotube apart from 15 upper surface of substrate is 50nm-200nm.
The present embodiment at work, is first put the reaction raw materials prepared into storing unit 5, is then controlled by controller 6
Syringe pump 7 processed so that syringe pump 7 provides power, and the reaction raw materials in storing unit 5 are injected into autoclave body 1 by injection-tube 4
Interior, flow controlling unit is capable of the flow of auxiliary adjustment raw material.
Reaction is carried out to when sometime putting, and reactant is contacted with the substrate 15 of detector, opens laser 10, laser
10 light sources sent out are transferred to probe 16 by input optical fibre 11, and detector receives the laser from probe 16 and sends out scattering
Light, the carbon nanotube 14 in the substrate 15 of detector can enhance scattered light intensity, these scattering light pass through probe 16, output again
Optical fiber 12 passes to Raman spectrometer 13, and Raman spectrometer 13 works, signal is analyzed, the spectral signal in Raman spectrum
It is identified, and be compared with the database of the spectral signal containing different kinds of molecules, find out corresponding standard substance, determine its title and
Structure, is then passed to controller 6, and testing result exports on the screen of controller 6.
The above is only the preferred embodiment of the present invention, is not intended to restrict the invention, it is noted that for this skill
For the those of ordinary skill in art field, without departing from the technical principles of the invention, can also make it is several improvement and
Modification, these improvements and modifications also should be regarded as protection scope of the present invention.
Claims (10)
1. a kind of medicine preparation process on-line measuring device, it is characterised in that：Including reaction kettle, injection device, Raman spectrum inspection
Examining system and controller, injection device injection reaction raw material into the reaction kettle, the injection device include injection
Pipe, the injection-tube are connected separately with storing unit and syringe pump, and the storing unit is used to hold reaction raw materials, the injection
Pump is connect with the controller；The Raman spectrum detection system includes laser, fibre optical sensor and Raman spectrometer, institute
It states Raman spectrometer and connects the controller, the fibre optical sensor is popped one's head in including a light scattering, and the light scattering probe includes
The detector popped one's head in described in probe and face, the probe connect the laser by input optical fibre, and the detector receives
Laser from probe simultaneously sends out scattering light, and light is scattered described in the probe collection and passes through output optical fibre and passes to the Raman
Spectrometer, the controller receive the output signal of the Raman spectrometer, and the detector includes substrate and the position of plane
In the nano-array of the substrate surface, the nano-array is made of multiple carbon nanotubes.
2. medicine preparation process on-line measuring device according to claim 1, it is characterised in that：The reaction kettle includes kettle
Body, the autoclave body are connected with heating unit, and the heating unit includes heating component and multiple temperature sensors, and the temperature passes
Sensor connects the controller.
3. medicine preparation process on-line measuring device according to claim 1, it is characterised in that：Also connect in the reaction kettle
Agitating unit is connected to, the stirrer paddle of the agitating unit is located at the autoclave body bottom.
4. medicine preparation process on-line measuring device according to claim 2, it is characterised in that：The heating component is in spiral shell
Rotation shape is looped around outside the autoclave body.
5. medicine preparation process on-line measuring device according to claim 2, it is characterised in that：The autoclave body and heating group
Heat transfer medium is equipped between part, the heating component is heated by being connected in the autoclave body between the heat transfer medium.
6. medicine preparation process on-line measuring device according to claim 2, it is characterised in that：Multiple temperature sensing
Device is arranged on the inner wall of the autoclave body, and multiple temperature sensors are uniformly arranged at equal intervals from top to bottom along the inner wall of the autoclave body
Cloth.
7. medicine preparation process on-line measuring device according to claim 1, it is characterised in that：The carbon nanotube top
Distance apart from the upper surface of substrate is 50nm-200nm.
8. medicine preparation process on-line measuring device according to claim 1, it is characterised in that：The probe and detector
Between be equipped with it is multiple for enhance detector scattered light signals focus lamp.
9. medicine preparation process on-line measuring device according to claim 1, it is characterised in that：The shape of the carbon nanotube
Shape is tapered or cylindrical.
10. medicine preparation process on-line measuring device according to claim 1, it is characterised in that：The syringe pump connection
There is flow controlling unit, the syringe pump is connect by the flow controlling unit with the controller.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810312086.XA CN108226140A (en) | 2018-04-09 | 2018-04-09 | A kind of medicine preparation process on-line measuring device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810312086.XA CN108226140A (en) | 2018-04-09 | 2018-04-09 | A kind of medicine preparation process on-line measuring device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108226140A true CN108226140A (en) | 2018-06-29 |
Family
ID=62657564
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810312086.XA Withdrawn CN108226140A (en) | 2018-04-09 | 2018-04-09 | A kind of medicine preparation process on-line measuring device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108226140A (en) |
-
2018
- 2018-04-09 CN CN201810312086.XA patent/CN108226140A/en not_active Withdrawn
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| PB01 | Publication | ||
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Application publication date: 20180629 |