CN108210168A - A kind of chitosan sustained-release microsphere gel adhesive bandage - Google Patents
A kind of chitosan sustained-release microsphere gel adhesive bandage Download PDFInfo
- Publication number
- CN108210168A CN108210168A CN201711324055.8A CN201711324055A CN108210168A CN 108210168 A CN108210168 A CN 108210168A CN 201711324055 A CN201711324055 A CN 201711324055A CN 108210168 A CN108210168 A CN 108210168A
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- China
- Prior art keywords
- chitosan
- adhesive bandage
- sustained
- adhesive tape
- gel
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000000853 adhesive Substances 0.000 title claims abstract description 32
- 230000001070 adhesive effect Effects 0.000 title claims abstract description 32
- 229920001661 Chitosan Polymers 0.000 title claims abstract description 30
- 239000004005 microsphere Substances 0.000 title claims abstract description 21
- 238000013268 sustained release Methods 0.000 title claims abstract description 21
- 239000012730 sustained-release form Substances 0.000 title claims abstract description 21
- 239000002390 adhesive tape Substances 0.000 claims abstract description 19
- 239000000758 substrate Substances 0.000 claims abstract description 15
- 229920002521 macromolecule Polymers 0.000 claims abstract description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 229940079593 drug Drugs 0.000 claims description 10
- 239000003814 drug Substances 0.000 claims description 10
- 239000008157 edible vegetable oil Substances 0.000 claims description 6
- 239000003921 oil Substances 0.000 claims description 6
- 235000019198 oils Nutrition 0.000 claims description 6
- 238000004132 cross linking Methods 0.000 claims description 4
- ABTOQLMXBSRXSM-UHFFFAOYSA-N silicon tetrafluoride Chemical compound F[Si](F)(F)F ABTOQLMXBSRXSM-UHFFFAOYSA-N 0.000 claims description 4
- WTEVQBCEXWBHNA-UHFFFAOYSA-N Citral Natural products CC(C)=CCCC(C)=CC=O WTEVQBCEXWBHNA-UHFFFAOYSA-N 0.000 claims description 3
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 3
- 150000001299 aldehydes Chemical class 0.000 claims description 3
- 229940043350 citral Drugs 0.000 claims description 3
- WTEVQBCEXWBHNA-JXMROGBWSA-N geranial Chemical compound CC(C)=CCC\C(C)=C\C=O WTEVQBCEXWBHNA-JXMROGBWSA-N 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 3
- 229960001699 ofloxacin Drugs 0.000 claims description 3
- 239000004006 olive oil Substances 0.000 claims description 3
- 235000008390 olive oil Nutrition 0.000 claims description 3
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 3
- 238000010557 suspension polymerization reaction Methods 0.000 claims description 3
- 239000003292 glue Substances 0.000 claims description 2
- 239000000575 pesticide Substances 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 abstract description 33
- 206010052428 Wound Diseases 0.000 abstract description 27
- 208000015181 infectious disease Diseases 0.000 abstract description 7
- 206010039509 Scab Diseases 0.000 abstract description 6
- 230000006378 damage Effects 0.000 abstract description 6
- 208000014674 injury Diseases 0.000 abstract description 6
- 244000052769 pathogen Species 0.000 abstract description 5
- 230000001717 pathogenic effect Effects 0.000 abstract description 5
- 230000002209 hydrophobic effect Effects 0.000 abstract description 4
- 239000002086 nanomaterial Substances 0.000 abstract description 4
- 230000035876 healing Effects 0.000 description 3
- 206010061926 Purulence Diseases 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000005251 gamma ray Effects 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- -1 5th Substances 0.000 description 1
- 241000193449 Clostridium tetani Species 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 238000007792 addition Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 239000011859 microparticle Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 241001148471 unidentified anaerobic bacterium Species 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/023—Adhesive bandages or dressings wound covering film layers without a fluid retention layer
- A61F13/0243—Adhesive bandages or dressings wound covering film layers without a fluid retention layer characterised by the properties of the skin contacting layer, e.g. air-vapor permeability
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/0246—Adhesive bandages or dressings characterised by the skin-adhering layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/07—Stiffening bandages
- A61L15/10—Stiffening bandages containing organic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/24—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00089—Wound bandages
- A61F2013/00314—Wound bandages with surface treatments
- A61F2013/00319—Wound bandages with surface treatments to make surface hydrophobic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00655—Plasters adhesive
- A61F2013/00676—Plasters adhesive hydrogel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/216—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
- A61L2300/406—Antibiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
- A61L2300/622—Microcapsules
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Materials Engineering (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention relates to a kind of chitosan sustained-release microsphere gel adhesive bandages, and including the double thin substrate adhesive tape layers of bottom and the high-molecular gel slow release layer on double thin substrate adhesive tape layers, the high-molecular gel slow release layer is inlays chitosan drug-loading microballoon on Macromolecule glue-line.Customization different sizes and shapes can be realized according to the wound size of patient using the gel adhesive bandage, use is more convenient, contributes to the secondary injury that faster heals and prevent scab from bringing of the wound in wet environment；The adhesive bandage can quickly form one layer of overlay film in wound surface, be equivalent to and play the role of temporary skin, and the micro-nano structure of sustained-release micro-spheres is but also script hydrophilic film becomes hydrophobic（Prevent pathogen infection）.
Description
Technical field
The invention belongs to field of medical article technology, and in particular to a kind of chitosan sustained-release microsphere gel adhesive bandage.
Background technology
There are following technical disadvantages for common adhesive bandage, and 1. the gas permeability of adhesive tape is bad, most common adhesive bandages
Gas permeability is very poor, this means that environment of the wound always in an intimate anaerobic.Two problems can be brought in this way, when
Certain anaerobic bacterias may obtain the chance of breeding, such as our common clostridium tetanis；Second is that wound is difficult healing（Wound
Cell after the stimulation of air is experienced, a series of reaction can be made, if superficial cell can necrosis, incrustation, internal is thin
Born of the same parents understand the healing that hyperplasia accelerates tissue）.So common people can take away adhesive bandage after wound is not bled, but in this way
The wound repeated infection pathogen of healing not yet is may result in, causes secondary inflammation.It is too small that 2. area is effectively treated, very
The shape of more wounds is irregular, as large area abrades.This when standby adhesive bandage be just entangled with very much, slight adhesive bandage root
This patch does not live.This wound is not deep when in fact a lot of, but since area is larger, the possibility of infection is quite big, this
Wound is very disagreeable, not serious but be easy to repeated infection.
Invention content
In order to solve the above technical problem, the present invention provides a kind of chitosan sustained-release microsphere gel adhesive bandages, solidifying using this
Glue adhesive bandage can realize customization different sizes and shapes according to the wound size of patient, and use is more convenient, contributes to wound
The secondary injury faster to heal and prevent scab from bringing in wet environment；The adhesive bandage can be quickly formed in wound surface
One layer of overlay film, is equivalent to and plays the role of temporary skin, and the micro-nano structure of sustained-release micro-spheres is but also script hydrophilic film becomes
It is hydrophobic（Prevent pathogen infection）.
The present invention is achieved through the following technical solutions, and the present invention provides a kind of chitosan sustained-release microsphere gel wound can
Patch, including the double thin substrate adhesive tape layers of bottom and the high-molecular gel slow release layer on double thin substrate adhesive tape layers, the macromolecule
Gel rubber sustained-release layer is inlays chitosan drug-loading microballoon on Macromolecule glue-line.
Preferably, it by polyvinyl alcohol water solution and citral is base material that the high-molecular gel slow release layer, which is, simultaneously
Chitosan drug-loading microballoon is added, is crosslinked to obtain the slow release layer being embedded on Macromolecule glue-line by gamma-ray irradiation.
Preferably, the chitosan drug-loading microballoon is using inverse suspension polymerization, it is water-soluble to contain using edible oil as oil phase
Property drug chitosan acid solution for water phase, water phase is added drop-wise in oil phase, after agitated mixing, edible aldehyde is added dropwise, crosslinking
Curing obtains.
Preferably, the water soluble drug is lavo-ofloxacin hydrochloride.
Preferably, the edible oil is olive oil.
Preferably, double thin substrate adhesive tape layers are that double tissue layers for dredging processing are carried out to adhesive tape layer using silicon fluoride.
The chitosan drug-loading microballoon plays the role of slowly releasing the drug；Macromolecule glue-line, chitosan sustained-release microsphere and double
Substrate adhesive tape layer composition is dredged, the environment of slightly sour micro- oxygen, the speed that wound heals under wet environment can be formed in wound surface
It is faster than dryness environment, prevents from forming a scab, avoids because incrustation brings the secondary injury to wound, while plays the work of temporary skin
With.
Beneficial effects of the present invention are：
1）Customization different sizes and shapes can be realized according to the wound size of patient using the gel adhesive bandage, use is more square
Just, contribute to the secondary injury that faster heals and prevent scab from bringing of the wound in wet environment.
2）General adhesive bandage uses 3-4 hour, and the adhesive bandage can use 8-24 hour, and effectively inhale purulence
It is antibacterial.
3）The adhesive bandage can quickly form one layer of overlay film in wound surface, be equivalent to and play the role of temporary skin,
And the micro-nano structure of sustained-release micro-spheres is but also script hydrophilic film becomes hydrophobic（Prevent pathogen infection）.
Description of the drawings
In order to illustrate more clearly about the embodiment of the present invention or technical scheme of the prior art, to embodiment or will show below
There is attached drawing needed in technology description to be briefly described, it should be apparent that, the accompanying drawings in the following description is only this
Some embodiments of invention, for those of ordinary skill in the art, without creative efforts, can be with
Other attached drawings are obtained according to these attached drawings.
Fig. 1 is inventive gel adhesive bandage structure top view；
Fig. 2 is inventive gel adhesive bandage cross-sectional view of the structure；
Fig. 3 is inventive gel adhesive bandage structural side view；
Fig. 4 is the bottom view of double thin substrate adhesive tape layers；
Fig. 5 is gel rubber sustained-release layer drug release schematic diagram；
In figure：1st, chitosan drug-loading microballoon, 2, Macromolecule glue-line, 3, double thin substrate adhesive tape layers, 4, silicon fluoride micro-and nano-particles,
5th, fabric warp and weft.
Specific embodiment
In order to make the purpose , technical scheme and advantage of the present invention be clearer, with reference to embodiments, to the present invention
It is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not used to
Limit the present invention.
With reference to and specific embodiment to the present invention application principle be further described.
Embodiment 1, such as Fig. 1-5, a kind of chitosan sustained-release microsphere gel adhesive bandage, including the double thin substrate adhesive tape layers 3 of bottom
With the high-molecular gel slow release layer on double thin substrate adhesive tape layers 3, the high-molecular gel slow release layer is in high-molecular gel
Chitosan drug-loading microballoon 1 is inlayed on layer 2.
The high-molecular gel slow release layer is is base material, while add chitosan by polyvinyl alcohol water solution and citral
Drug bearing microsphere is crosslinked to obtain the slow release layer being embedded on Macromolecule glue-line 2 by gamma-ray irradiation.
The chitosan drug-loading microballoon 1 is using inverse suspension polymerization, using edible oil as oil phase, with containing water-soluble drug
Chitosan acid solution is water phase, and water phase is added drop-wise in oil phase, after agitated mixing, edible aldehyde is added dropwise, crosslinking curing obtains.
The water soluble drug is lavo-ofloxacin hydrochloride.The edible oil is olive oil.Double thin substrate adhesive tape layers 3
For silicon fluoride is used to carry out double tissue layers for dredging processing to adhesive tape layer.
The chitosan drug-loading microballoon 1 plays the role of slowly releasing the drug；Macromolecule glue-line 2,1 and of chitosan sustained-release microsphere
Double thin substrate adhesive tape layers 3 form, and the environment of slightly sour micro- oxygen, the speed that wound heals under wet environment can be formed in wound surface
Degree is faster than dryness environment, prevents from forming a scab, and avoids because incrustation brings the secondary injury to wound, while plays the work of temporary skin
With.
The present invention 1）Customization different sizes and shapes can be realized according to the wound size of patient using the gel adhesive bandage,
Using more convenient, contribute to the secondary injury that faster heals and prevent scab from bringing of the wound in wet environment.
2）General adhesive bandage uses 3-4 hour, and the adhesive bandage can use 8-24 hour, and effectively inhale purulence
It is antibacterial.
3）The adhesive bandage can quickly form one layer of overlay film in wound surface, be equivalent to and play the role of temporary skin,
And the micro-nano structure of sustained-release micro-spheres is but also script hydrophilic film becomes hydrophobic（Prevent pathogen infection）.
Certainly, above description is also not limited to the example above, the technical characteristic of the invention without description can by or
It is realized using the prior art, details are not described herein；It is not to this that above example, which is merely to illustrate technical scheme of the present invention,
The limitation of invention is described in detail the present invention with reference to preferred embodiment, and those of ordinary skill in the art should
Understand, the variations, modifications, additions or substitutions that those skilled in the art are made in the essential scope of the present invention
Without departure from spirit of the invention, it should also belong to the claims of the present invention.
Claims (6)
1. a kind of chitosan sustained-release microsphere gel adhesive bandage, it is characterised in that：Including the double thin substrate adhesive tape layers of bottom（3）With positioned at
Double thin substrate adhesive tape layers（3）On high-molecular gel slow release layer, the high-molecular gel slow release layer be in Macromolecule glue-line（2）
On inlay chitosan drug-loading microballoon（1）.
2. a kind of chitosan sustained-release microsphere gel adhesive bandage according to claim 1, it is characterised in that：The Macromolecule
Glue slow release layer passes through gamma-rays to be base material, while add chitosan drug-loading microballoon by polyvinyl alcohol water solution and citral
Cross-linking radiation obtains being embedded in Macromolecule glue-line（2）On slow release layer.
3. a kind of chitosan sustained-release microsphere gel adhesive bandage according to claim 1 or 2, it is characterised in that：The shell gathers
Sugared drug bearing microsphere（1）It is using inverse suspension polymerization, using edible oil as oil phase, with the chitosan acid solution of containing water-soluble drug
For water phase, water phase is added drop-wise in oil phase, after agitated mixing, edible aldehyde is added dropwise, crosslinking curing obtains.
4. a kind of chitosan sustained-release microsphere gel adhesive bandage according to claim 3, it is characterised in that：The water-soluble pesticide
Object is lavo-ofloxacin hydrochloride.
5. a kind of chitosan sustained-release microsphere gel adhesive bandage according to claim 3, it is characterised in that：The edible oil is
Olive oil.
6. a kind of chitosan sustained-release microsphere gel adhesive bandage according to claim 1, it is characterised in that：Double thin substrates
Adhesive tape layer（3）For silicon fluoride is used to carry out double tissue layers for dredging processing to adhesive tape layer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711324055.8A CN108210168A (en) | 2017-12-13 | 2017-12-13 | A kind of chitosan sustained-release microsphere gel adhesive bandage |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711324055.8A CN108210168A (en) | 2017-12-13 | 2017-12-13 | A kind of chitosan sustained-release microsphere gel adhesive bandage |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108210168A true CN108210168A (en) | 2018-06-29 |
Family
ID=62649462
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711324055.8A Pending CN108210168A (en) | 2017-12-13 | 2017-12-13 | A kind of chitosan sustained-release microsphere gel adhesive bandage |
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| Country | Link |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109966053A (en) * | 2019-04-24 | 2019-07-05 | 四川省乐至贵均卫生材料有限公司 | A kind of aloe band-aid |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1067251A (en) * | 1991-05-25 | 1992-12-23 | 上海科学技术大学 | The synthetic method of chemicals slow-release type hydrogel film |
| US20020122771A1 (en) * | 2000-09-23 | 2002-09-05 | Troy Holland | Spray hydrogel wound dressings |
| CN102010515A (en) * | 2010-10-21 | 2011-04-13 | 浙江大学 | Method for preparing natural hydrophobic and oleophobic cellulose material |
| CN102302458A (en) * | 2011-09-15 | 2012-01-04 | 中国人民解放军军事医学科学院卫生装备研究所 | Long-acting sustained-release wound dressing containing levofloxacin sustained-release microspheres, and preparation method thereof |
| CN204839932U (en) * | 2015-07-14 | 2015-12-09 | 嘉恒医药（江苏）有限公司 | Scar dressing |
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2017
- 2017-12-13 CN CN201711324055.8A patent/CN108210168A/en active Pending
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Application publication date: 20180629 |