CN108210134A - A kind of intravascular stent - Google Patents
A kind of intravascular stent Download PDFInfo
- Publication number
- CN108210134A CN108210134A CN201810161805.2A CN201810161805A CN108210134A CN 108210134 A CN108210134 A CN 108210134A CN 201810161805 A CN201810161805 A CN 201810161805A CN 108210134 A CN108210134 A CN 108210134A
- Authority
- CN
- China
- Prior art keywords
- section
- local
- intravascular stent
- stent
- intravascular
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010002329 Aneurysm Diseases 0.000 claims abstract description 28
- 208000031481 Pathologic Constriction Diseases 0.000 claims abstract description 19
- 230000036262 stenosis Effects 0.000 claims abstract description 19
- 208000037804 stenosis Diseases 0.000 claims abstract description 19
- 238000000034 method Methods 0.000 claims abstract description 13
- 230000002792 vascular Effects 0.000 claims abstract description 13
- 210000004204 blood vessel Anatomy 0.000 claims description 18
- 201000003808 Cystic echinococcosis Diseases 0.000 claims description 5
- 206010014096 Echinococciasis Diseases 0.000 claims description 5
- 208000009366 Echinococcosis Diseases 0.000 claims description 5
- 230000002440 hepatic effect Effects 0.000 claims description 5
- 208000037834 fusiform aneurysm Diseases 0.000 claims description 4
- 238000002513 implantation Methods 0.000 claims description 4
- 230000004323 axial length Effects 0.000 claims description 3
- 238000010146 3D printing Methods 0.000 claims description 2
- 239000011248 coating agent Substances 0.000 claims description 2
- 238000000576 coating method Methods 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 239000000463 material Substances 0.000 claims description 2
- 229910052751 metal Inorganic materials 0.000 claims description 2
- 239000002184 metal Substances 0.000 claims description 2
- 238000009941 weaving Methods 0.000 claims description 2
- 238000009434 installation Methods 0.000 claims 1
- 238000010147 laser engraving Methods 0.000 claims 1
- 229910052755 nonmetal Inorganic materials 0.000 claims 1
- 230000036770 blood supply Effects 0.000 abstract description 6
- 230000007812 deficiency Effects 0.000 abstract description 3
- 239000012530 fluid Substances 0.000 description 8
- 239000008280 blood Substances 0.000 description 6
- 210000001367 artery Anatomy 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 230000017531 blood circulation Effects 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 201000008450 Intracranial aneurysm Diseases 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 229910045601 alloy Inorganic materials 0.000 description 1
- 239000000956 alloy Substances 0.000 description 1
- 210000000709 aorta Anatomy 0.000 description 1
- 210000000702 aorta abdominal Anatomy 0.000 description 1
- 208000007474 aortic aneurysm Diseases 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 238000001361 intraarterial administration Methods 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 230000000873 masking effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- HLXZNVUGXRDIFK-UHFFFAOYSA-N nickel titanium Chemical compound [Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni] HLXZNVUGXRDIFK-UHFFFAOYSA-N 0.000 description 1
- 229910001000 nickel titanium Inorganic materials 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 229920000747 poly(lactic acid) Polymers 0.000 description 1
- 239000004626 polylactic acid Substances 0.000 description 1
- 238000005381 potential energy Methods 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0063—Three-dimensional shapes
Abstract
The invention discloses a kind of intravascular stents, belong to medical vascular stent technical field.The present invention cannot be effectively isolated the deficiency that branch vessel blood supply is hindered after aneurysm cavity pressure or bifurcated vessels intervention support for aneurysm stent, a kind of novel intravascular stent is provided, the intravascular stent is the intravascular stent that a kind of partial cross section becomes smaller or larger, with local stenosis section and local bulkiness section, the pressure value of intravascular part can be changed, and the operation difficulty of the existing implanted prosthetics of intravascular stent will not be increased by changing the method for intravascular stent local diameter.
Description
Technical field
The invention belongs to medical vascular stent technical field, more particularly to a kind of implantation aneurysm or vascular bifurcation position
Intravascular stent.
Background technology
Aneurysm is disease multiple in arterial system, shows as artery local bulkiness, tube wall mechanical properties decrease.Artery
The rupture of knurl is by abnormally dangerous or even life-threatening.Common and dangerous two larger class aneurysms are main respectively in clinic
Aneurysm and intracranial aneurysm.Aortic aneurysm is mainly in aorta pectoralis and abdominal aorta, mostly in fusiform.Intracranial aneurysm is happened at
The hepatic hydatid disease that entocranial artery, mostly side expand.Interventional method be operation reduce aneurysm in pressure, prevent its increase and
One of main method of rupture.Aneurysm site intervention support can weaken work of the Intraarterial pressure to knurl to a certain extent
With, but effect unobvious sometimes.
Blood vessel intervention also has a kind of reluctant situation, exactly intervenes position and there are bifurcated vessels.Work as blood vessel
After the main blood vessel of stenter to implant, one side scaffolding thread can form bifurcated vessels entrance a degree of masking, on the other hand, stent
The shape of bifurcated vessels entrance can be changed during strutting.These two aspects is it is possible that influence the blood supply of bifurcated vessels, Jin Erying
Ring the organ-/ tissue normal physiological function in bifurcated vessels downstream.
Invention content
After the present invention cannot be effectively isolated aneurysm cavity pressure or bifurcated vessels intervention support for aneurysm stent
The deficiency of branch vessel blood supply is hindered, provides a kind of novel intravascular stent, the intravascular stent can both reduce aneurysm
Interior pressure value, and the effect of aneurysm interventional treatment can be improved；And for intervention position bifurcated after intravascular stent intervention
The deficiency of blood vessel blood supply reduction, intravascular stent provided by the invention can increase pressure and then the increase of bifurcated vessels inlet
Bifurcated vessels blood supply.
The present invention provides a kind of intravascular stent, and the intravascular stent is a kind of close middle section local radial section phase
For the intravascular stent that rack body radial section becomes smaller or larger, there is support blood vessels wall, reduction or increase local vascular pressure
The effect of power.The local radial section becomes fraction and is known as local stenosis section, and the local radial section becomes most of
Referred to as local bulkiness section.The length a and hepatic hydatid disease of the local stenosis section expire along between the Opening length b of blood vessel axial direction
Foot：0.8b<a<1.2b；The length a of the local stenosis section meets with fusiform aneurysm along the knurl length c of blood vessel axial direction：
0.8c<a<1.2c；The axial length of the local bulkiness section is 0.8-3 times of implantation punishment fork blood vessels caliber.
Intravascular stent provided by the invention, when for aneurysm treatment, the intravascular stent local diameter is less than stent
Ontology diameter.When for vascular bifurcation position interventional treatment, intravascular stent local diameter is more than rack body diameter.In order to suitable
Answer different shape, various sizes of aneurysm, can design different ontology diameters, different ontologies with it is narrow or expand position
Diameter than, it is different narrow or expand segment length.The intravascular stent of different size series can also be designed, is made for selection of clinical
With to meet clinical needs.
Preferably, the vascular stent material can be metal, as stainless steel, Nitinol, magnesium base alloy, iron-based close
It is golden etc. or nonmetallic, such as polylactic acid, the intravascular stent can be bare bracket or medicine coating blood vessel
Stent or degradable blood vessel bracket.
Preferably, the intravascular stent can be made by laser carving method or weaving method be made or
Person's 3D printing method obtains.
The advantage of the invention is that：
1st, intravascular stent provided by the invention can be changed intravascular by changing the method for intravascular stent local diameter
The pressure value of part.
2nd, the operation difficulty of the existing implanted prosthetics of intravascular stent will not be increased.
Description of the drawings
Figure 1A is the schematic shapes of the intravascular stent provided by the invention with local stenosis section；
Figure 1B is the schematic shapes of the intravascular stent provided by the invention with local bulkiness section；
Fig. 2 is that stent is put into fusiform aneurysm position schematic diagram in embodiment 1；
Fig. 3 is that stent is put into hepatic hydatid disease position schematic diagram in embodiment 2；
Fig. 4 is that stent is put into bifurcated vessels position schematic diagram in embodiment 3.
In figure：
1. vascular wall；2. intravascular stent.
Specific embodiment
With reference to specific embodiment, the present invention is further illustrated.It should be understood that these embodiments are merely to illustrate the present invention
Rather than it limits the scope of the invention.In addition, it should also be understood that, after reading the content taught by the present invention, people in the art
Member can make various changes or modifications the present invention, and such equivalent forms equally fall within the application the appended claims and limited
Range.
According to Bernoulli equation, in the case where height factor is ignored, fluids within pipes flowing velocity and flowing pressure are in
Shifting changing rule (i.e. kinetic energy is mutually converted with pressure potential).
Bernoulli equation (Bernoulli equation) or bernoulli principle (Bernoulli principle) are
Fundamental equation and principle in hydrodynamics.The principles illustrated is for perfect fluid, i.e. non-sticky incompressible fluid, in weight
When steady flow is done in the field of force, the functional relationship of perfect fluid.Formula is expressed as：
Wherein：P is local pressure, and ρ is fluid density, and v is fluid linear velocity, and g is acceleration of gravity, and h is position height
Value, footnote 1,2 represent position 1 and 2 respectively.
When can be regarded as perfect fluid and doing steady flow, at the arbitrary section of same flow tube, at this pressure potential energy (pressure) and
The sum of kinetic energy, gravitional force in unit volume are a constant.
Blood flow in arteries is approximately to meet Bernoulli equation by the present invention, for the blood of intravascular stent intervention
Pipe part, gravitional force item (ρ gh) are varied less, can be ignored.Then it is constant the sum of first two only to be remained in formula.In blood flow
When caliber attenuates, flowing velocity (v) can rise, the kinetic energy of streamwise unit volume bloodIncrease, pressure
(p) will decline therewith.Similarly, when flowing caliber is increased, pressure will rise therewith.
For the intravascular stent 2 with local stenosis section, as shown in Figure 1A, at the position that local diameter d becomes smaller, according to stream
Body continuity equation and Bernoulli equation, flow velocity can increase in the position, and pressure declines therewith.When 1 adaptability of vascular wall is grown
It fits on the outside of intravascular stent outer surface or intravascular stent after forming thrombus, this Bernoulli effect can be more obvious.When blood
When pipe holder narrow section is placed on corresponding aneurysm site, pressure can also decrease in knurl, play protection aneurysm, inhibit
It increases or the trend of rupture.The intravascular stent of the local stenosis type can be used for fusiform aneurysm, it can also be used to capsule artery
Knurl while can causing impact to aneurysm using intravascular stent blocking blood flow, further utilizes Bernoulli equation principle to drop
Pressure in low aneurysm reduces the risk of aneurysm increase and rupture.
For the intravascular stent 2 with local bulkiness section, as shown in Figure 1B, in the local bulkiness section of intravascular stent, equally
According to fluid continuity equation and Bernoulli equation, flow velocity can reduce in the position, and pressure increases.Can will have in this way
The intravascular stent of local bulkiness section is used at bifurcated vessels, is conducive to the blood supply of bifurcated vessels at this.
Embodiment 1
As shown in Fig. 2, by conventional intravascular stent interventional method, by the blood provided by the invention with local stenosis section
Pipe holder 2 is placed into hepatic hydatid disease position, and local stenosis section is located at aneurysm inlet, the conventional section outer wall of intravascular stent 2
It is bonded with vascular wall 1.Perfect condition is：The length a and Opening length b of the aneurysm along blood vessel axial direction of the local stenosis section
Equal or 0.8b<a<1.2b can also set a as array of sizes, in order to which selection of clinical uses.The local stenosis section it is narrow
Narrow sectional area is not more than the 30% of the position normal vessel lumen sectional area.The intravascular stent ontology diameter being commonly designed with it is required
The vessel diameter at intravascular stent position is equal or slightly larger than vessel diameter.
Embodiment 2
As shown in figure 3, by conventional intravascular stent interventional method, by the blood provided by the invention with local stenosis section
Pipe holder is placed into netraneurysm position, and the local stenosis section is located at aneurysm site, outside the conventional section of intravascular stent 2
Wall is bonded with vascular wall 1.Perfect condition is：The length a of local stenosis section and knurl of the aneurysm along blood vessel axial direction on intravascular stent
Body length c is equal or 0.8c<a<1.2c can also set a as array of sizes, in order to which selection of clinical uses.Local stenosis section
30% of stenosed section product no more than the position normal vessel lumen sectional area.The intravascular stent ontology diameter being commonly designed and institute
Need the vessel diameter at intravascular stent position equal or slightly larger than vessel diameter.
Embodiment 3
As shown in figure 4, by conventional intravascular stent interventional method, by the blood provided by the invention with local bulkiness section
Pipe holder is placed into bifurcated vessels position, and the conventional section outer wall of intravascular stent 2 is bonded with vascular wall 1.Perfect condition is：Part is swollen
Big section is placed on bifurcated vessels inlet, and local bulkiness section expands sectional area no more than the main vascular cross-section product of crotch
30%, the axial length a of local bulkiness section are 0.8-3 times of implantation punishment fork blood vessels caliber d, can also set a as array of sizes,
In order to which selection of clinical uses.
Claims (4)
1. a kind of intravascular stent, it is characterised in that：The intravascular stent is provided with local radial section phase close to middle section
Part is become smaller or larger for intravascular stent ontology radial section, the local radial section becomes fraction and is known as local stenosis
Section, the local radial section become most of and are known as local bulkiness section；The length a and hepatic hydatid disease of the local stenosis section
Meet along between the Opening length b of blood vessel axial direction：0.8b<a<1.2b；The length a and fusiform aneurysm of the local stenosis section
Meet along the knurl length c of blood vessel axial direction：0.8c<a<1.2c；The axial length of the local bulkiness section is implantation punishment fork
0.8-3 times of blood vessels caliber.
2. a kind of intravascular stent according to claim 1, it is characterised in that：The vascular stent material is metal or non-
Metal, the intravascular stent are bare bracket or medicine coating blood vessel support or degradable blood vessel bracket.
3. a kind of intravascular stent according to claim 1, it is characterised in that：The intravascular stent passes through laser engraving side
Method, which is made, to be either made using weaving method or is made using 3D printing method.
4. a kind of intravascular stent according to claim 1, it is characterised in that：The local stenosis section or local bulkiness section
Sectional area variable quantity is not more than the 30% of institute's installation position normal vessel lumen sectional area.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810161805.2A CN108210134A (en) | 2018-02-27 | 2018-02-27 | A kind of intravascular stent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810161805.2A CN108210134A (en) | 2018-02-27 | 2018-02-27 | A kind of intravascular stent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108210134A true CN108210134A (en) | 2018-06-29 |
Family
ID=62662206
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810161805.2A Pending CN108210134A (en) | 2018-02-27 | 2018-02-27 | A kind of intravascular stent |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108210134A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030100945A1 (en) * | 2001-11-23 | 2003-05-29 | Mindguard Ltd. | Implantable intraluminal device and method of using same in treating aneurysms |
| US20090043187A1 (en) * | 2007-06-08 | 2009-02-12 | Siemens Aktiengesellschaft | Method for assessing a rupture risk of an aneurysm of a patient and associated system |
| US20100318175A1 (en) * | 2007-12-31 | 2010-12-16 | C.R. Bard, Inc. | Vascular graft prosthesis with selective flow reduction |
| CN208435872U (en) * | 2018-02-27 | 2019-01-29 | 北京航空航天大学 | A kind of intravascular stent |
-
2018
- 2018-02-27 CN CN201810161805.2A patent/CN108210134A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050010281A1 (en) * | 2001-07-09 | 2005-01-13 | Ofer Yodfat | Implantable intraluminal device and method of using same in treating aneurysms |
| US20030100945A1 (en) * | 2001-11-23 | 2003-05-29 | Mindguard Ltd. | Implantable intraluminal device and method of using same in treating aneurysms |
| US20090043187A1 (en) * | 2007-06-08 | 2009-02-12 | Siemens Aktiengesellschaft | Method for assessing a rupture risk of an aneurysm of a patient and associated system |
| US20100318175A1 (en) * | 2007-12-31 | 2010-12-16 | C.R. Bard, Inc. | Vascular graft prosthesis with selective flow reduction |
| CN208435872U (en) * | 2018-02-27 | 2019-01-29 | 北京航空航天大学 | A kind of intravascular stent |
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