CN108209992A - Ligament fixing screws - Google Patents
Ligament fixing screws Download PDFInfo
- Publication number
- CN108209992A CN108209992A CN201810065188.6A CN201810065188A CN108209992A CN 108209992 A CN108209992 A CN 108209992A CN 201810065188 A CN201810065188 A CN 201810065188A CN 108209992 A CN108209992 A CN 108209992A
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- CN
- China
- Prior art keywords
- nail
- cover
- fixing screws
- barbed
- sliding block
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0401—Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0401—Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors
- A61B2017/0408—Rivets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0401—Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors
- A61B2017/0427—Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors having anchoring barbs or pins extending outwardly from the anchor body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0401—Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors
- A61B2017/0464—Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors for soft tissue
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Surgical Instruments (AREA)
Abstract
The present invention provides a kind of ligament fixing screws, comprising nail lid (1) and nail pin (2), multiple nail pins (2) are connected to nail lid (1) in axial direction on one of end face of two end faces；Multiple nail pins (2) are arranged along nail lid (1) circumferential direction, and threading gap (3) is formed between multiple nail pins (2)；In projection in axial direction, the projection of the nail pin (2) is located in the projection outer profile of nail lid (1) in whole or in part；In the both ends of nail pin (2) in axial direction with respect to nail lid (1) institute at one end the other end formation tip；Hangnail (4) is provided in nail pin (2).The present invention is designed using bidentate (hangnail), on the one hand can effectively increase resisting pull out forces, on the other hand, also avoids leading to the defects of trepanning is excessive on bone using annular barb structure.
Description
Technical field
The present invention relates to medical instruments fields, and in particular, to a kind of ligament fixing screws.
Background technology
In ligament reconstructive operation, by the way that ligament fixing screws can be used, for the both ends of ligament are directly or indirectly solid
It is scheduled on ligament attachment bone.In the prior art, ligament fixing screws use helicitic texture more, but in use, easily
Thread failure or screw thread self-locking insufficient strength occur leads to situation about circumferentially rotating.There is also use the tough of barb structure at present
Band fixing screws, but such screw general diameter is larger, adheres to the bone cavity space that trepanning is formed on bone and also increases therewith, both increased
The workload of operation is added, but also the wound increase of Shu Zhong patient autologous tissue.
Invention content
For the defects in the prior art, the object of the present invention is to provide a kind of ligament fixing screws.
According to ligament fixing screws provided by the invention, comprising nail lid and nail pin, it is axial that multiple nail pins are connected to nail cover rim
On one of end face of direction Liang Ge end faces；
Multiple nail pins are arranged along nail lid circumferential direction, and threading gap is formed between multiple nail pins；In axial direction
In projection, the projection of the nail pin is located in the projection outer profile of nail lid in whole or in part；
In the both ends of nail pin in axial direction with respect to nail lid institute at one end the other end formation tip；It is provided with down in nail pin
Thorn.
Preferably, the nail pin includes sleeve and barbed sliding block, and the hangnail is located on barbed sliding block；
The sleeve is covered tightly with nail to be solidly connected, and barbed sliding block relative sleeve, which slides, to do well this in hidden state and thorn
It is converted between two states：
Under the hidden state, barbed sliding block is integrally located in sleeve；
The thorn does well down, and the hangnail of barbed sliding block reaches the exterior space of sleeve.
Preferably, the nail lid includes the first cover and the second cover, and the first cover is rotatablely connected with the second cover；
The barbed sliding block includes guidance part and thorn conjunction portion, and guidance part is fastenedly connected with thorn conjunction portion；
Arc driver slot is provided in first cover, radial direction guide groove is provided in the second cover, guidance part slides wear simultaneously
It is located in arc driver slot and radial direction guide groove；
Arc driver slot along the first cover circumferential direction extend when radial position in the first cover there is variation.
Preferably, the both ends of the arc driver slot along its length are respectively formed minor axis end and major diameter end, radially side
Upwards, minor axis end with respect to major diameter end close to the central shaft of the first cover；
Card hole is provided on major diameter end, card hole is interconnected with arc driver slot.
Preferably, it is provided with injection orifice in the barbed sliding block；Injection orifice includes main aperture and branch hole, and main aperture and branch hole are mutual
Connection；
The main aperture extends along barbed length extending direction, and branch hole is through the circumferential end faces in thorn conjunction portion.
Preferably, along on end to the direction at tip, the aperture in multiple branch holes is sequentially increased where nail lid.
Preferably, screw rod is provided in the first cover, internal thread hole is provided in the second cover, screw rod is threaded through in described
In threaded hole.
Preferably, it is connected on the other end in the both ends of the screw rod in axial direction with respect to end where the first cover seamed
Line holdfast；
Ligament mounting hole is provided in the suture holdfast.
Preferably, the suture holdfast includes the first suture and the second suture；
There are different on degradation rate from the second suture for first suture.
Preferably, the nail covers and is provided with cable hole, the wall surface of the hole and the end face of head cover in axial direction of cable hole it
Between seamlessly transit.
Compared with prior art, the present invention has following advantageous effect：
1st, the present invention is designed using bidentate (hangnail), on the one hand can effectively increase resisting pull out forces, on the other hand, is also avoided
The defects of trepanning is excessive on bone is led to using annular barb structure；
2nd, the present invention can be fully implanted in by way of percussion in bone, simple operation, while avoids local convex protrusion shadow
Ring joint motion and appearance；
3rd, the barbed slide position of the present invention can be adjusted, and reduce implant procedure difficulty when hiding, in implant angle or position
There are being adjusted after fixing screws can also be taken out during deviation, after fixing screws implantation in place, barbed sliding block is ejected,
It realizes and is reliably fixed under the action of hangnail；
4th, be provided with the channel injected for bone cement in barbed sliding block, by bone cement preferably by the present invention with bone it
Between be fixed；
5th, it is empty full of bone cavity by squeezing suture holdfast for being provided with suture holdfast in the fixed space of ligament
Between, playing the role of secondary fixed while soft suture holdfast to ligament can also prevent that ligament is caused to hurt.
Description of the drawings
Upon reading the detailed description of non-limiting embodiments with reference to the following drawings, other feature of the invention,
Objects and advantages will become more apparent upon：
Fig. 1 adheres to pore structure schematic diagram on bone for ligament；
Fig. 2 is ligament fixing screws structure diagram in embodiment；
Fig. 3 is ligament fixing screws vertical view in change case；
Fig. 4 is ligament fixing screws front section view in change case；
Fig. 5 is barbed sliding block cross-section structure schematic detail view in change case.
It is shown in figure：
Specific embodiment
With reference to specific embodiment, the present invention is described in detail.Following embodiment will be helpful to the technology of this field
Personnel further understand the present invention, but the invention is not limited in any way.It should be pointed out that the ordinary skill to this field
For personnel, without departing from the inventive concept of the premise, various modifications and improvements can be made.These belong to the present invention
Protection domain.
In the description of the present invention, it is to be understood that term " on ", " under ", "front", "rear", "left", "right", " perpendicular
Directly ", the orientation of the instructions such as " level ", " top ", " bottom ", " interior ", " outer " or position relationship are based on orientation shown in the drawings or position
Relationship is put, be for only for ease of the description present invention and simplifies description rather than instruction or implies that signified device or element are necessary
With specific orientation, with specific azimuth configuration and operation, therefore be not considered as limiting the invention.
As shown in Fig. 2, in embodiment, ligament fixing screws provided by the invention include nail lid 1 and nail pin 2, multiple nail pins 2
Nail lid 1 is connected in axial direction on one of end face of two end faces, multiple nail pins 2 are along nail 1 circumferential direction cloth of lid
It puts, threading gap 3 is formed between multiple nail pins 2, in projection in axial direction, the projection of the nail pin 2 is in whole or in part
In the projection outer profile of nail lid 1, in the both ends of nail pin 2 in axial direction it is opposite follow closely lid 1 the other end at one end formed
Tip is provided with hangnail 4 in nail pin 2.In actual use, bone cavity as shown in Figure 1 is first accomplished fluently on ligament attachment bone, it will
The present invention is directly knocked in bone cavity, and nail pin 2 is entered in corresponding osseous tunnel, and threading is threaded through for the artificial ligament of reconstruction
In gap 3, under the action of hangnail 4, the present invention is effectively prevent to deviate from from bone cavity, and since 2 cross-sectional area of nail pin is smaller,
Correspondingly, the osseous tunnel chiseled is needed also to become smaller on bone, reduces operating difficulty and wound.Head cover has a smooth surface transition,
On the one hand incised wound artificial ligament is prevented, local convex protrusion is on the other hand also prevented from and causes to wear with the scraping between its hetero-organization.
As shown in Figure 3, Figure 4, in change case, the nail pin 2 includes sleeve 5 and barbed sliding block 6, and the hangnail 4 is located at band
It pierces on sliding block 6, the sleeve 5 is fastenedly connected with nail lid 1, and barbed 6 relative sleeve 5 of sliding block slip can be in hidden state with piercing out
It is converted between both states of state, under the hidden state, barbed sliding block 6 is integrally located in sleeve 5, and the thorn does well
Under, the hangnail 4 of barbed sliding block 6 reaches the exterior space of sleeve 5.By the above-mentioned design present invention in the mistake for being implanted to bone cavity
Cheng Zhong reduces the friction between bone, and operation is more laborsaving, in addition, there are also be able to during deviation when implant angle and position
It is finely adjusted, hangnail 4 is ejected after being implanted into place, is conducive to the present invention and is fixed firmly in bone cavity, prevent from coming off.To drive
Dynamic, the nail lid 1 includes the first cover 7 and the second cover 8, and the first cover 7 is rotatablely connected with the second cover 8, the barbed cunning
Block 6 includes guidance part 9 and thorn conjunction portion 10, and guidance part 9 is fastenedly connected with thorn conjunction portion 10, and arc driving is provided in the first cover 7
Slot 11, radial direction guide groove 12 is provided in the second cover 8, and guidance part 9 slides be threaded through arc driver slot 11 and radial direction guide groove simultaneously
In 12, arc driver slot 11 along 7 circumferential direction of the first cover extend when radial position in the first cover 7 there is variation.It is logical
The first cover 7 of rotation is crossed, barbed sliding block 6 is driven to move in radial directions, so as to stretch out 4 relative sleeve 5 of hangnail or retract.
Preferably, the both ends of the arc driver slot 11 along its length are respectively formed minor axis end and major diameter end, radially on, it is short
Diameter end is provided with card hole 13, card hole 13 and arc driver slot 11 with respect to major diameter end on the central shaft of the first cover 7, major diameter end
It is interconnected, when the first cover 7 turns to certain angle, in bone cavity wall under the active force in thorn conjunction portion 10, guidance part 9 enters
It into card hole 13, can not circumferentially rotate again, it is integrally-built sealed to complete the present invention itself.
In preference, as shown in figure 5, being provided with injection orifice 14 in the barbed sliding block 6；Injection orifice 14 include main aperture 15 with
Branch hole 16, main aperture 15 are interconnected with branch hole 16, and the main aperture 15 extends along barbed 6 length extending direction of sliding block, and branch hole 16 is passed through
Puncture the circumferential end faces in conjunction portion 10.Along along 1 place end to the direction at tip of nail lid, the aperture in multiple branch holes 16 increases successively
Greatly.Bone cement can be injected in nail pin 2 by injection orifice 14, the space in sleeve 5 on the one hand can be filled, make entire nail pin
2 structures are more stablized, and on the other hand can also will be further fixed between nail pin 2 and bone, increase fixing intensity.Preferably,
Screw rod 17 is provided in first cover 7, internal thread hole is provided in the second cover 8, screw rod 17 is threaded through in the internal thread hole.
Suture holdfast 18, institute are connected on the other end in the both ends of the screw rod 17 in axial direction with respect to 7 place end of the first cover
It states and ligament mounting hole is provided in suture holdfast 18.The suture holdfast 18 includes the first suture and the second suture, the first suture
There are different on degradation rate from the second suture.Screw rod 17 plays the role of a rotation central axis, prevents the first cover 7 and
It is radially slided between two covers 8.Suture holdfast 18 is the holdfast made of suture, and advantage is, due to suture itself material compared with
Softness will not cause to hurt, and knocking in ligament fixing screws to artificial ligament, and bone cavity space reduces, by suture
Holdfast 18 is extruded in bone cavity, plays the role of the secondary anchoring to artificial ligament.In preference, the suture holdfast 18 can be with
It is integrally fixed in the second cover 8.During degradation, tissue can grow to artificial ligament for first suture and the second suture
On, the first suture has differences with the second suture degradation rate, it is ensured that enough fixing intensities are kept in degradation process, are prevented
Only increase causes artificial ligament to loosen suddenly in gap.In preference, cable hole 19 is provided on the nail lid 1, cable hole 19
Wall surface of the hole and head cover seamlessly transit between end face in axial direction, prevent incised wound artificial ligament.The setting of cable hole 19, is convenient for
Artificial ligament is pierced by, and for the ligament fixing screws structure that change case provides, the edge of the first cover 7 sets arcuate socket, the
A smaller trepanning is only separately provided in two covers 8 enables artificial ligament to be pierced by, when rotating the first cover 7 in this way, no
Artificial ligament can be affected to circumferentially rotate.
Specific embodiments of the present invention are described above.It is to be appreciated that the invention is not limited in above-mentioned
Particular implementation, those skilled in the art can make various deformations or amendments within the scope of the claims, this not shadow
Ring the substantive content of the present invention.In the absence of conflict, the feature in embodiments herein and embodiment can arbitrary phase
Mutually combination.
Claims (10)
1. a kind of ligament fixing screws, which is characterized in that comprising nail lid (1) and nail pin (2), multiple nail pins (2) are connected to nail lid
(1) in axial direction on one of end face of two end faces；
Multiple nail pins (2) are arranged along nail lid (1) circumferential direction, and threading gap (3) is formed between multiple nail pins (2)；Along axis
Into the projection in direction, the projection of the nail pin (2) is located in the projection outer profile of nail lid (1) in whole or in part；
In the both ends of nail pin (2) in axial direction with respect to nail lid (1) institute at one end the other end formation tip；Nail pin is set on (2)
It is equipped with hangnail (4).
2. ligament fixing screws according to claim 1, which is characterized in that the nail pin (2) comprising sleeve (5) with it is barbed
Sliding block (6), the hangnail (4) is on barbed sliding block (6)；
The sleeve (5) is fastenedly connected with nail lid (1), and barbed sliding block (6) relative sleeve (5) is slided can be in hidden state and thorn
It is converted between both states that do well：
Under the hidden state, barbed sliding block (6) is integrally located in sleeve (5)；
The thorn does well down, and the hangnail (4) of barbed sliding block (6) reaches the exterior space of sleeve (5).
3. ligament fixing screws according to claim 2, which is characterized in that it is described nail lid (1) comprising the first cover (7) with
Second cover (8), the first cover (7) are rotatablely connected with the second cover (8)；
The barbed sliding block (6) includes guidance part (9) and thorn conjunction portion (10), and guidance part (9) is fastenedly connected with thorn conjunction portion (10)；
Arc driver slot (11) is provided in first cover (7), radial direction guide groove (12), guidance part are provided in the second cover (8)
(9) while slip is threaded through in arc driver slot (11) and radial direction guide groove (12)；
Arc driver slot (11) along the first cover (7) circumferential direction extend when radial position in the first cover (7) exist and become
Change.
4. ligament fixing screws according to claim 3, which is characterized in that the arc driver slot (11) is along its length
Both ends be respectively formed minor axis end and major diameter end, radially on, minor axis end is with respect to major diameter end in the first cover (7)
Mandrel；
Card hole (13) is provided on major diameter end, card hole (13) is interconnected with arc driver slot (11).
5. ligament fixing screws according to claim 4, which is characterized in that be provided with injection in the barbed sliding block (6)
Hole (14)；Injection orifice (14) includes main aperture (15) and branch hole (16), and main aperture (15) is interconnected with branch hole (16)；
The main aperture (15) extends along barbed sliding block (6) length extending direction, and branch hole (16) are through the circumferential end of thorn conjunction portion (10)
Face.
6. ligament fixing screws according to claim 5, which is characterized in that along end where nail lid (1) to the direction at tip
On, the aperture of multiple branch holes (16) is sequentially increased.
7. ligament fixing screws according to claim 3, which is characterized in that screw rod (17) is provided in the first cover (7),
Internal thread hole is provided in second cover (8), screw rod (17) is threaded through in the internal thread hole.
8. ligament fixing screws according to claim 7, which is characterized in that the both ends of the screw rod (17) in axial direction
In be connected with suture holdfast (18) on the other end with respect to end where the first cover (7)；
Ligament mounting hole is provided in the suture holdfast (18).
9. ligament fixing screws according to claim 8, which is characterized in that the suture holdfast (18) includes the first suture
With the second suture；
There are different on degradation rate from the second suture for first suture.
10. according to the ligament fixing screws described in claim 1,2 or 3, which is characterized in that be provided with away on the nail lid (1)
String holes (19), the wall surface of the hole and head cover of cable hole (19) seamlessly transit between end face in axial direction.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810065188.6A CN108209992B (en) | 2018-01-23 | 2018-01-23 | Ligament fixation screw |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810065188.6A CN108209992B (en) | 2018-01-23 | 2018-01-23 | Ligament fixation screw |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108209992A true CN108209992A (en) | 2018-06-29 |
| CN108209992B CN108209992B (en) | 2023-06-20 |
Family
ID=62667455
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810065188.6A Active CN108209992B (en) | 2018-01-23 | 2018-01-23 | Ligament fixation screw |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108209992B (en) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4263903A (en) * | 1979-01-08 | 1981-04-28 | Richards Manufacturing Co., Inc. | Medical staple means |
| US4454875A (en) * | 1982-04-15 | 1984-06-19 | Techmedica, Inc. | Osteal medical staple |
| FR2682587A1 (en) * | 1991-10-21 | 1993-04-23 | Laboureau Jacques Philippe | Surgical ligamentary nail and associated ancillary instrumentation |
| FR2715290A1 (en) * | 1994-01-25 | 1995-07-28 | Newpact Eurl | Surgical staple for ligaments |
| CN107348978A (en) * | 2017-07-07 | 2017-11-17 | 上海利格泰生物科技有限公司 | Full suture holdfast and implanted mechanism |
| CN206681766U (en) * | 2017-03-13 | 2017-11-28 | 山东科技大学 | A kind of new winding shape secondary grouting anchor pole |
| CN208625778U (en) * | 2018-01-23 | 2019-03-22 | 上海利格泰生物科技有限公司 | Ligament fixing screws |
-
2018
- 2018-01-23 CN CN201810065188.6A patent/CN108209992B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4263903A (en) * | 1979-01-08 | 1981-04-28 | Richards Manufacturing Co., Inc. | Medical staple means |
| US4454875A (en) * | 1982-04-15 | 1984-06-19 | Techmedica, Inc. | Osteal medical staple |
| FR2682587A1 (en) * | 1991-10-21 | 1993-04-23 | Laboureau Jacques Philippe | Surgical ligamentary nail and associated ancillary instrumentation |
| FR2715290A1 (en) * | 1994-01-25 | 1995-07-28 | Newpact Eurl | Surgical staple for ligaments |
| CN206681766U (en) * | 2017-03-13 | 2017-11-28 | 山东科技大学 | A kind of new winding shape secondary grouting anchor pole |
| CN107348978A (en) * | 2017-07-07 | 2017-11-17 | 上海利格泰生物科技有限公司 | Full suture holdfast and implanted mechanism |
| CN208625778U (en) * | 2018-01-23 | 2019-03-22 | 上海利格泰生物科技有限公司 | Ligament fixing screws |
Also Published As
| Publication number | Publication date |
|---|---|
| CN108209992B (en) | 2023-06-20 |
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Address after: 201700 Room 301, Building 1, No. 508 Tianchen Road, Qingpu District, Shanghai Applicant after: Shanghai Ligetai Biotechnology Co.,Ltd. Address before: 201700 Room 301, Building 1, No. 508 Tianchen Road, Qingpu District, Shanghai Applicant before: SHANGHAI LIGETAI BIOLOGICAL TECHNOLOGY Co.,Ltd. |
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