CN108187212A - A kind of medicinal balloon - Google Patents
A kind of medicinal balloon Download PDFInfo
- Publication number
- CN108187212A CN108187212A CN201810209446.3A CN201810209446A CN108187212A CN 108187212 A CN108187212 A CN 108187212A CN 201810209446 A CN201810209446 A CN 201810209446A CN 108187212 A CN108187212 A CN 108187212A
- Authority
- CN
- China
- Prior art keywords
- drug
- balloon
- recessed portion
- balloon body
- medicinal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 claims abstract description 41
- 229940079593 drug Drugs 0.000 claims abstract description 38
- 150000004676 glycans Chemical class 0.000 claims abstract description 24
- 239000002872 contrast media Substances 0.000 claims description 14
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims description 3
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims description 3
- 229960002930 sirolimus Drugs 0.000 claims description 3
- 230000023597 hemostasis Effects 0.000 abstract description 4
- 230000002792 vascular Effects 0.000 abstract description 4
- 238000010586 diagram Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000000916 dilatatory effect Effects 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 239000002700 tablet coating Substances 0.000 description 1
- 238000009492 tablet coating Methods 0.000 description 1
- 229940043263 traditional drug Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/105—Balloon catheters with special features or adapted for special applications having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/1075—Balloon catheters with special features or adapted for special applications having a balloon composed of several layers, e.g. by coating or embedding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/1079—Balloon catheters with special features or adapted for special applications having radio-opaque markers in the region of the balloon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/1086—Balloon catheters with special features or adapted for special applications having a special balloon surface topography, e.g. pores, protuberances, spikes or grooves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/12—Blood circulatory system
Abstract
The present invention relates to a kind of medicinal balloon, the conduit being connect including balloon body and with the balloon body, the outer surface of the balloon body is provided with drug, and core glycan film is enclosed on the outside of the drug.Medicinal balloon provided by the invention, by setting core glycan film on the outside of drug, can effectively protect drug prevents drug to be largely lost in；In addition, there is hemostasis to the open sore part in operation since the expansion of air bag, core glycan film are attached on vascular wall when using.
Description
Technical field
The present invention relates to the field of medical instrument technology, especially with regard to a kind of medicinal balloon.
Background technology
Angiocardiopathy has been increasingly becoming the number one killer of the mankind, already as modern society's incidence, disability rate highest
Disease.China has caused people to pay much attention to there is a large amount of angiocardiopathy people at highest risk at present.
At present in the operation for the treatment of angiocardiopathy, medicinal balloon is a kind of common hemostasis device, traditional drug ball
Capsule is on the basis of dilating sacculus, and upper drug will be smeared on the balloon body of dilating sacculus and is made, this sacculus is being transported
During sending, drug can be caused largely to be lost in conveyance conduit wall and blood vessel wall friction, therefore, the medicine of traditional medicinal balloon
Object utilization rate is relatively low, and administering effect is poor.
Invention content
Therefore, the purpose of the present invention is to provide a kind of medicinal balloon, to solve the above problems.
The technical scheme is that：A kind of medicinal balloon is led including balloon body and with what the balloon body was connect
Pipe, the outer surface of the balloon body is provided with drug, core glycan film is enclosed on the outside of the drug.
Optionally, the core glycan film is layer 2-3.
Optionally, the drug is：Rapamycin and/or, derivative.
Optionally, it is provided with contrast agent between the outer surface of the balloon body and the core glycan film.
Optionally, the contrast agent is located at the inside of the drug.
Optionally, the outer surface of the balloon body is provided with the first recessed portion, and it is recessed that the contrast agent is located at described first
In concave portion, the drug is located at the surrounding of first recessed portion；Sacculus in the expanded state, the opening of first recessed portion
Diameter be less than the first recessed portion maximum gauge.
Optionally, the outer surface of the balloon body is provided with the second recessed portion, and the drug is located at the described second recess
In portion；In the expanded state, the diameter of the opening of second recessed portion is less than the maximum gauge of the second recessed portion to sacculus.
Medicinal balloon provided by the invention, by setting core glycan film on the outside of drug, can effectively protect drug prevents medicine
Object is largely lost in；In addition, there is hemostasis to the open sore part in operation since the expansion of air bag, core glycan film are attached on vascular wall when using
Effect.
Description of the drawings
Fig. 1 shows a kind of structure diagram of medicinal balloon provided by the invention；
Fig. 2 shows a kind of setting structure figures of the drug of medicinal balloon of Fig. 1；
Fig. 3 shows a kind of concrete structure schematic diagram of medicinal balloon provided by the invention；
Fig. 4 shows one of section structure diagram of balloon body；
Fig. 5 shows enlarged drawings of the Fig. 4 at A；
Fig. 6 shows the section second structural representation of balloon body；
Fig. 7 shows enlarged drawings of the Fig. 6 at B；
Wherein, conduit -11；Balloon body -12；Drug -13；Core glycan film -14；Intake valve -15；Tracheae -16；Seal wire-
17；First recessed portion -18；Contrast agent -19；Second recessed portion -20.
Specific embodiment
Technical scheme of the present invention is described in detail below in conjunction with the accompanying drawings.
Embodiment 1, the present invention provides a kind of medicinal balloon, referring to Fig. 1 and Fig. 2, including balloon body 12 and with it is described
The conduit 11 of balloon body connection, the outer surface of the balloon body is provided with drug 13, core is enclosed on the outside of the drug
Glycan film 14, as a preferred solution, the core glycan film are layer 2-3, and the drug is：Rapamycin and/or,
Derivative.
Medicinal balloon provided by the invention, by setting core glycan film on the outside of drug, can effectively protect drug prevents medicine
Object is largely lost in；In addition, there is hemostasis to the open sore part in operation since the expansion of air bag, core glycan film are attached on vascular wall when using
Effect, in addition, by the outside of drug set core glycan film, residence time of the drug at the open sore part can be extended, slow down trouble
Person's vessel endothelialisation speed.
In the application, in order to facilitate the operation, referring to Fig. 3, seal wire 17 in the conduit is installed and is connected with balloon body
Tracheae 16, the tracheae and the seal wire expose the described one end of conduit far from the balloon body, and the tracheae exposes institute
It states the one end of conduit far from the balloon body and is provided with intake valve 15, inflated with facilitating to balloon body.
Embodiment 2, on the basis of embodiment 1, for the ease of observing internal surgery situation, the appearance of the balloon body
Contrast agent is provided between face and the core glycan film, the setting of contrast agent can use existing mode, generally, described make
Shadow agent is located at the inside of the drug.As a kind of plan of establishment, referring to Fig. 4 and Fig. 5, the outer surface setting of the balloon body
There is the first recessed portion 18, the contrast agent 19 is located in first recessed portion, and the drug 13 is located at first recessed portion
Surrounding；In the expanded state, the diameter of the opening of first recessed portion is less than the maximum of first recessed portion directly to sacculus
Diameter can also set in the opening of the first recessed portion and be provided with protective film, and degradable film generally can be used in protective film, certainly
Core glycan film can also be directly used, i.e. core glycan film is more than the thickness of other positions in the position thickness of the opening of the first recessed portion
Degree in this way, at the open sore part, since the core glycan film of drug package is thinner than the core glycan film that contrast agent wraps up, is more easily damaged, because
This drug can reach open sore part position prior to contrast agent, prevent contrast agent from first reaching open sore part position and influencing dispenser, this structure, when
During inflated, recessed portion deformation ejects the contrast agent in recessed portion, and the package of core glycan film is this field skill
Known to art personnel, for example the technology of tablet coating is applicable in, details are not described herein again.
Embodiment 3, on the basis of embodiment 1, referring to Fig. 6 and Fig. 7, the outer surface of the balloon body is provided with second
Recessed portion 20, the drug 13 are located in second recessed portion；Sacculus in the expanded state, the opening of second recessed portion
Diameter be less than second recessed portion maximum gauge, this structure, sacculus in a contracted state, since balloon body is that have
Elasticity, therefore the opening contraction of the first recessed portion almost wraps drug, is more advantageous to preventing drug wastage, be filled when to sacculus
During gas, depressed deformation ejects the drug in recess, is contacted with vascular wall, in the process, core glycan film is also easy
Swelling fracture, more conducively dispenser.
Above-described embodiment is the illustration invented, and it is special should not to describe limitation with the exemplary embodiments of specification and attached drawing
The protection domain of economic rights.
The preferred embodiments of the disclosure and embodiment are explained in detail above in conjunction with attached drawing, but it is of the invention
The above-described embodiment and examples are not limited to, in the knowledge having in those skilled in the art, can also not taken off
Various changes can be made under the premise of from present inventive concept.In the claims, should not will between bracket it is any with reference to symbol
Number be used as limitations on claims.Word "comprising" does not exclude the presence of element or step not listed in the claims.
Claims (7)
1. a kind of medicinal balloon, including balloon body (12) and the conduit (11) being connect with the balloon body, which is characterized in that
The outer surface of the balloon body is provided with drug (13), and core glycan film (14) is enclosed on the outside of the drug.
2. medicinal balloon according to claim 1, which is characterized in that the core glycan film is layer 2-3.
3. medicinal balloon according to claim 1, which is characterized in that the drug is：
Rapamycin and/or,
Its derivative.
4. medicinal balloon according to claim 1, which is characterized in that the outer surface of the balloon body and the core glycan
Contrast agent is provided between film.
5. medicinal balloon according to claim 4, which is characterized in that the contrast agent is located at the inside of the drug.
6. medicinal balloon according to claim 4, which is characterized in that it is recessed that the outer surface of the balloon body is provided with first
Concave portion (18), for the contrast agent (19) in first recessed portion, the drug is located at the surrounding of first recessed portion；
In the expanded state, the diameter of the opening of first recessed portion is less than the maximum gauge of first recessed portion to sacculus.
7. medicinal balloon according to claim 1, which is characterized in that it is recessed that the outer surface of the balloon body is provided with second
Concave portion (20), the drug are located in second recessed portion；
In the expanded state, the diameter of the opening of second recessed portion is less than the maximum gauge of second recessed portion to sacculus.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810209446.3A CN108187212B (en) | 2018-03-14 | 2018-03-14 | Medicine balloon |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810209446.3A CN108187212B (en) | 2018-03-14 | 2018-03-14 | Medicine balloon |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108187212A true CN108187212A (en) | 2018-06-22 |
| CN108187212B CN108187212B (en) | 2022-07-15 |
Family
ID=62595748
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810209446.3A Expired - Fee Related CN108187212B (en) | 2018-03-14 | 2018-03-14 | Medicine balloon |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108187212B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108853690A (en) * | 2018-08-14 | 2018-11-23 | 张海军 | A kind of film envelope drug storage sacculus and preparation method |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6585926B1 (en) * | 2000-08-31 | 2003-07-01 | Advanced Cardiovascular Systems, Inc. | Method of manufacturing a porous balloon |
| GB2400804B (en) * | 2003-03-29 | 2006-03-15 | Smiths Group Plc | Medical devices |
| US20090227949A1 (en) * | 2008-03-06 | 2009-09-10 | Boston Scientific Scimed, Inc. | Balloon catheter devices with folded balloons |
| CN101564571A (en) * | 2001-09-10 | 2009-10-28 | 艾博特公司 | Medical apparatus containing rapamycin analogue |
| CN101785900A (en) * | 2010-03-10 | 2010-07-28 | 成都维德医疗器械有限责任公司 | Medicinal balloon catheter and preparation method thereof |
| CN102512747A (en) * | 2011-12-27 | 2012-06-27 | 微创医疗器械(上海)有限公司 | Medicine eluting balloon catheter |
| CN103764218A (en) * | 2011-07-26 | 2014-04-30 | 美敦力瓦斯科尔勒公司 | Textured dilatation balloon |
| CN203763644U (en) * | 2014-03-21 | 2014-08-13 | 深圳脉动医学技术有限公司 | Multi-curative-effect balloon catheter |
| CN205698848U (en) * | 2016-04-15 | 2016-11-23 | 上海康德莱医疗器械股份有限公司 | A kind of drug coated balloon catheter |
| CN206560590U (en) * | 2016-11-29 | 2017-10-17 | 美昕医疗器械（上海）有限公司 | Sustained-release administration catheter |
-
2018
- 2018-03-14 CN CN201810209446.3A patent/CN108187212B/en not_active Expired - Fee Related
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6585926B1 (en) * | 2000-08-31 | 2003-07-01 | Advanced Cardiovascular Systems, Inc. | Method of manufacturing a porous balloon |
| CN101564571A (en) * | 2001-09-10 | 2009-10-28 | 艾博特公司 | Medical apparatus containing rapamycin analogue |
| GB2400804B (en) * | 2003-03-29 | 2006-03-15 | Smiths Group Plc | Medical devices |
| US20090227949A1 (en) * | 2008-03-06 | 2009-09-10 | Boston Scientific Scimed, Inc. | Balloon catheter devices with folded balloons |
| CN101785900A (en) * | 2010-03-10 | 2010-07-28 | 成都维德医疗器械有限责任公司 | Medicinal balloon catheter and preparation method thereof |
| CN103764218A (en) * | 2011-07-26 | 2014-04-30 | 美敦力瓦斯科尔勒公司 | Textured dilatation balloon |
| CN102512747A (en) * | 2011-12-27 | 2012-06-27 | 微创医疗器械(上海)有限公司 | Medicine eluting balloon catheter |
| CN203763644U (en) * | 2014-03-21 | 2014-08-13 | 深圳脉动医学技术有限公司 | Multi-curative-effect balloon catheter |
| CN205698848U (en) * | 2016-04-15 | 2016-11-23 | 上海康德莱医疗器械股份有限公司 | A kind of drug coated balloon catheter |
| CN206560590U (en) * | 2016-11-29 | 2017-10-17 | 美昕医疗器械（上海）有限公司 | Sustained-release administration catheter |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108853690A (en) * | 2018-08-14 | 2018-11-23 | 张海军 | A kind of film envelope drug storage sacculus and preparation method |
Also Published As
| Publication number | Publication date |
|---|---|
| CN108187212B (en) | 2022-07-15 |
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| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20220715 |
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| CF01 | Termination of patent right due to non-payment of annual fee |