CN108186802A - A kind of Chinese medicine composition for preventing or treating leukoplakia vulvae and preparation method thereof - Google Patents

A kind of Chinese medicine composition for preventing or treating leukoplakia vulvae and preparation method thereof Download PDF

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CN108186802A
CN108186802A CN201810189769.0A CN201810189769A CN108186802A CN 108186802 A CN108186802 A CN 108186802A CN 201810189769 A CN201810189769 A CN 201810189769A CN 108186802 A CN108186802 A CN 108186802A
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chinese medicine
medicine composition
fruit
radix
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CN108186802B (en
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尹巧芝
张吉仲
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Chengdu University of Traditional Chinese Medicine
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Abstract

The invention belongs to tcm fields, disclose a kind of Chinese medicine composition, and the bulk pharmaceutical chemicals comprising following parts by weight are made：10~30 parts of cultivated land, 10~30 parts of the fruit of Chinese wolfberry, 10~30 parts of Radix Astragali, 5~22 parts of Radix Angelicae Sinensis, 10~30 parts of Radix Salviae Miltiorrhizae, 10~30 parts of the fruit of summer cypress, 10~30 parts of the root bark of shaggy-fruited dittany.Chinese medicine composition of the present invention can be used for preventing or treat leukoplakia vulvae, while the invention also discloses a kind of method for preparing the Chinese medicine composition, be prepared with plant oil extract.Each herbal medicine influences each other, acts synergistically in Chinese medicine composition of the present invention, reaches kidney-replenishing blood-nourishing, promoting blood circulation itching-relieving action, and treating both manifestation and root cause of disease is significant in efficacy.Chinese medicine composition preparation method of the present invention is easy to operate, production cost is low, efficient.

Description

A kind of Chinese medicine composition for preventing or treating leukoplakia vulvae and preparation method thereof
Technical field
The invention belongs to tcm fields, and in particular to it is a kind of prevent or treatment leukoplakia vulvae Chinese medicine composition and Preparation method.
Background technology
Leukoplakia vulvae refers to that one group of chronic disease of denaturation and pigment alteration occurs for female vulva skin and mucous membrane tissue Disease.Be commonly called as leukoplakia vulvae, dystrophy of vulva, show as pruritus vulvue more, skin of vulva mucous membrane whitens, is coarse, thicken chap, Ulcer, elasticity attenuation or even big nymphae atresia, vagina stenostomia, dyspareunia, dyspareunia.Leukoplakia vulvae Any age can be betided, in the majority with the premenopausal rear women of 50 years old or so, the course of disease is different in size, and elder is up to many decades.Its The course of disease is long, high recurrence rate, is a kind of common Gynecological stubborn diseases, seriously affects the physical and mental health of patient, International Health Organization is Precancerous lesion is formally classified as, China Academy of TCM is classified as worldwide difficult treatment.
The cause of disease and pathogenesis of leukoplakia vulvae are still not clear, modern medicine think its with endocrine disorder, heredity, The factors such as wound, inflammation, complication are related, and symptomatic treatment is mainly used in terms for the treatment of to control itch, extra-nutrition, anti-sense Dye and the normal morphology for restoring skin of vulva, such as local topical cortin, sex hormone, multivitamin and antibiotic, hand Art or physiotherapy.Since the pathogenesis of leukoplakia vulvae is unclear, it is relatively inaccessible to preferably using above-mentioned therapeutic scheme Therapeutic effect.If glucocorticoid medicine is the drug that doctor trained in Western medicine first choice treats leukoplakia vulvae, although for main itch Symptom has certain mitigation, but histology is not improved, and long-term continuous use can cause local skin atrophy etc. is secondary to make With also some patientss hormone therapy is ineffective or even invalid.It is preferable that Triamcinolone acetonide curative effect is subcutaneously injected, but multiple injection, Increase pain and the financial burden of patient.There are the possibility of patient's late relapse for operative treatment, and wound is larger, and patient is difficult to Receive.
It is recorded in Chinese medical book without this name of disease, but symptom, sign according to this disease, yin disease is such as " cloudy before being divided into Itch ", " erosion of vulva ", the disease categories such as " erosion of vulva ".《The deficient the truth opinion of Plain Questions gold》：" kidney, have one's ideas straightened out Yu Eryin ".《Ling Shu Miraculous Pivot or Divine Axis passages through which vital energy circulates》： " the liver meridian of Foot-JUE YIN enters in hair, ring external genitals ".《Plain Questions is fainted opinion》：" external genitalia person, the institute of penis is poly-, and the bright institute of lunar sun closes ." Zhang Fuqin,《The cause of disease, the interpretation of the cause, onset and process of an illness and the pharmacotherapeutics progress of " leukoplakia vulvae "》, summarize the cause of disease disease of this sick theory of traditional Chinese medical science Reason, it is believed that the occurrence of this disease is in close relations with liver,spleen,kidney, and mechanism is：Liver Channel is around external genitals, main store blood；Kidney governing reproduction is had one's ideas straightened out In two the moon；Spleen governing muscles.Clinical manifestation can be divided into empty and real two kinds of symptoms.So-called void person refers to that the deficiency of blood loses flourish dryness-transformation, so that Punching appoint it is deficient, private parts lose support or it is warm caused by；So-called reality person, be due to liver depression gram spleen soil, liver heat and spleen is wet, it is wet with hot phase Mutually dipping, punching, which is appointed, to be damaged, and private parts is caused to be held back by wet and thermal resistance, causes this disease.Clinically based on the chronic diseases marked by deficiency of vital energy, even the case of a physically strong patient running a high fever is also This void is common to have deficiency of blood dryness-transformation, the deficiency of liver-yin and kidney-yin, the insufficiency of both the spleen and the kindey and dampness-heat of liver channel caused by by heresy.
Chinese patent CN 101129986A disclose a kind of Chinese medicine preparation for treating leukoplakia vulvae, the patent document Disclosed Chinese medicine preparation is made of the bulk pharmaceutical chemicals that following weight matches：1.5 ~ 6 parts of Semen Cuscutae, 1.5 ~ 6 parts of prepared rehmannia root, rhizoma anemarrhenae 1.5 ~ 6 parts, 1.0 ~ 4 parts of psoralea corylifolia, 1.0 ~ 4 parts of Radix Angelicae Sinensis, 0.1 ~ 2 part of Cortex Phellodendri, 1.0 ~ 4 parts of Semen Ziziphi Spinosae (parched), 0.1 ~ 2 part of tribulus terrestris, radix bupleuri 0.1 ~ 2 part, 1.0 ~ 4 parts of prepared fleece flower root, 0.1 ~ 2 part of the fruit of summer cypress, 0.1 ~ 2 part of Radix Curcumae.Cultivated land of the Chinese medicine preparation to tonify the liver and kidney Yellow, rhizoma anemarrhenae and Semen Cuscutae are monarch drug in a prescription, how first with kidney tonifying, antitoxic heart-soothing and sedative, the Cortex Phellodendri of clearing heat and detoxicating defecation, Radix Angelicae Sinensis, Semen Ziziphi Spinosae (parched), system Crow, radix bupleuri and psoralea corylifolia are ministerial drug, and using analgesic, antipruritic Radix Curcumae, tribulus terrestris and the fruit of summer cypress as adjuvant, all medicines share has altogether The effect of nourishing liver and kidney, ecchymose removing.The raw materials used medicine of the Chinese medicine preparation is more, and for oral preparations, daily 2-3 times, once It one bag, needs to take for a long time, formula is containing the fleece-flower root, it is possible to create toxic side effect.
Chinese patent CN104258232A discloses a kind of pharmaceutical preparation for being used to treat leukoplakia vulvae, the drug system Agent using the tuber of stemona, myrrh, cortex acanthopanacis etc. totally two ten Six-element Chinese medicines as bulk pharmaceutical chemicals, repeatedly add water to cook, filter after be prepared, the system Agent employ the dispelling wind and arresting itching drugs such as hundred steps, myrrh, Centipeda minima, the root bark of shaggy-fruited dittany, uncaria, pivots storage, the fruit of summer cypress, Chinese tamarisk tops and The drug of the nourshing blood and promoting blood circulation such as Caulis Spatholobi, madder, Radix Salviae Miltiorrhizae, Assorted Chinese Herbal Tea, cortex acanthopanacis, the fruit of glossy privet, eclipta, adenophora tetraphylla warm kidney strengthening the essence, But dosage is less, and the efficacy of a drug is relatively slow, and full side is using nourshing blood and promoting blood circulation, dispelling wind and arresting itching as the main principles of formulating prescriptions, and flavour of a drug are more, for itch Symptom carries out local application, does not take into account liver and spleen kidney this void and is treated, exists and be difficult to the risk for effecting a radical cure recurrent exerbation.It was administered Journey needs to daub into vagina using instrument auxiliary, and medication process is cumbersome.
Chinese patent CN103550544A discloses a kind of for treating the Chinese medicine composition of leukoplakia vulvae and tanning and right The device of diseased region atomization process, includes：Chinese medicine composition I is set as by 25-45 grams of kuh-seng, 55-75 grams of Radix Salviae Miltiorrhizae, Cortex Phellodendri 10-35 grams, 35-50 grams of frutus cnidii, 60-75 grams of the fruit of summer cypress, 7-9 grams of Radix Angelicae Sinensis, 6-8 grams of Radix Astragali, 10-15 grams of dragon's blood, Ramulus Taxilli 10- 15 grams, 5-9 grams of the Chinese bulbul, 35-40 grams of blackberry lily, 10-20 grams of radix rehmanniae recen, 30-40 grams of psoralea corylifolia, 20-25 grams of dipsacus root, Moschus 10- 50-70 grams of 35 grams, 5-8 grams of Asian puccoon, 6-9 grams of Eclipta prostrata, 10-15 grams of caulis bambusae in taenian and borneol form；Chinese medicine composition II be set as by 80-90 grams of cape jasmine, 50-70 grams of coix seed, 30-45 grams of akebi, 25-45 grams of Semen Cuscutae, 10-20 grams of oriental wormwood and siritch（Gu claims, That is sesame oil）Appropriate composition.Drug I is made of the drug of multi-flavor detoxifying and relieving itching, clearing heat and promoting diuresis, mainly for wet and hot mutual leaching The real example of stain is treated, and drug II is made of the drug of multi-flavor purging intense heat clearing damp, plays the role of clearing heat and detoxicating clearing damp；But two Group drug cooperation, still without liver kidney spleen this void is taken into account, exists and is difficult to the risk for effecting a radical cure recurrent exerbation.
Invention content
Flavour of a drug in the prior art are complicated, do not have the problems such as treating both manifestation and root cause of disease it is an object of the invention to overcoming, and facing On the basis of bed Couple herbs, using theory of traditional Chinese medical science as guidance, with reference to the asthenia in origin and asthenia in superficiality pathogenic characteristic of leukoplakia vulvae, in Cure treatment thinkings, it is proposed that the principle of reatment for the treatment of both manifestation and root cause of disease emphasized based on " benefit ", provides a kind of treat vulva on this basis The Chinese medicine composition of white lesions, is especially to provide that a kind of formula is simple, prepares convenient, safe and non-toxic, treating both manifestation and root cause of disease external application Chinese medicine preparation.
The traditional Chinese medical science thinks that this disease interpretation of the cause, onset and process of an illness is asthenia in origin and asthenia in superficiality.This void is liver and spleen kidney deficiency, asthenia of essence and blood；Mark is really in private parts Venation block.Blood stored in the liver, network are had mercy on external genitals.Kidney storing essence, post two are cloudy.If kidney deficiency and liver, spleen deficiency source is insufficient, blood and essence asthenia, cloudy Portion's failure of skin and muscle to be nourished causes private parts to dry up and bleaches；Asthenia of essence and blood, wind formation from blood deficiency dryness-transformation, dryness tending to desiccate, easy impairment of yin Tianjin；Liver depression with the passing of time, secretly Liver-yin or liver depression forming fire are consumed, cloudy blood of burning, cause liver blood is more empty, and private parts is difficult to support；Empty then more susceptible heresy forms simulataneous insufficiency and excessive. Its result causes essence and blood more to lose, and private parts more loses that Rong Ze colors are white, all diseases of chap are heavier；Sense is evil repeatedly, then the diseases difficulty such as itch is removed.
The present invention provides following technical scheme according to the characteristics of this disease asthenia in origin and asthenia in superficiality：
A kind of Chinese medicine composition is made of the bulk pharmaceutical chemicals comprising following parts by weight：
10~30 parts of cultivated land, 10~30 parts of the fruit of Chinese wolfberry, 10~30 parts of Radix Astragali, 5~22 parts of Radix Angelicae Sinensis,
10~30 parts of Radix Salviae Miltiorrhizae, 10~30 parts of the fruit of summer cypress, 10~30 parts of the root bark of shaggy-fruited dittany.
In above-mentioned Chinese medicine composition, cultivated land is monarch drug in a prescription, nourishing yin and supplementing blood, beneficial to spirit and marrow, to treat caused by blood and essence asthenia Private parts failure of skin and muscle to be nourished；The fruit of Chinese wolfberry, Radix Astragali, when being classified as ministerial drug, wherein fruit of Chinese wolfberry nourishing the kidney and the liver with strengthen monarch drug in a prescription effect embody it is " kind to mend Cloudy person, must be in treating YIN within YANG, then YIN matched with sufficient YANG making living things fully vivid " therapy, Radix Astragali acted on by benefiting qi and nourishing blood with strengthening monarch drug in a prescription, Chinese angelica blood supplementing and blood are acted on, while Radix Astragali, Radix Angelicae Sinensis compatibility with strengthening monarch drug in a prescription, can play the role of benefiting qi for promoting production of blood, and the monarch and his subjects coordinate, Invigorating liver and spleen kidney, fundamentally solves blood and essence asthenia, so that private parts loses this void caused by supporting or being warm；Radix Salviae Miltiorrhizae, the fruit of summer cypress, The root bark of shaggy-fruited dittany is assistant, then feels evil with treatment void, the accompanying symptoms such as caused itch, wherein Radix Salviae Miltiorrhizae nourshing blood and promoting blood circulation, and embodiment " controls wind first to control Blood, blood wind is from going out " therapy；The fruit of summer cypress, the root bark of shaggy-fruited dittany are clearing heat and detoxicating, dispelling wind and arresting itching, further mitigate pruritis, solve this Mark of the void caused by by heresy is real, and treating both manifestation and root cause of disease reaches healing purpose.
Further, the Chinese medicine composition is made of the bulk pharmaceutical chemicals comprising following parts by weight：
10~30 parts of cultivated land, 10~30 parts of Chinese yam, 10~30 parts of Fructus Corni,
10~30 parts of Semen Cuscutae, 10~30 parts of the fruit of Chinese wolfberry, 10~30 parts of Radix Astragali, 5~22 parts of Radix Angelicae Sinensis,
10~30 parts of Radix Salviae Miltiorrhizae, 10~30 parts of the fruit of summer cypress, 10~30 parts of the root bark of shaggy-fruited dittany.
In Traditional Chinese medicine composition formula of the present invention, cultivated land nourishing yin and supplementing blood, beneficial to spirit and marrow, to treat the moon caused by blood and essence asthenia Portion's failure of skin and muscle to be nourished；Chinese yam kidney and spleen invigorating nourishes kidney channel, the help deficiency of Yin；Fructus Corni tonifies the liver and kidney, and gram void is good for reality, beneficial to Liver Channel kidney Through strong；The effect of providing kidney tonifying essence, benefiting essence-blood from different channels and collaterals, three taste medicines are altogether monarch drug in a prescription, and efficacy effect is stronger；Semen Cuscutae, The fruit of Chinese wolfberry, Radix Astragali, when being classified as minister, wherein Semen Cuscutae and fruit of Chinese wolfberry nourishing the kidney and the liver embody that " kind tonifying yin person, must to strengthen monarch drug in a prescription effect The therapy of in treating YIN within YANG, then YIN matched with sufficient YANG making living things fully vivid ", Semen Cuscutae enhancing fruit of Chinese wolfberry nourishing effect, regulating yin and yang rise it is poly-, Radix Astragali is acted on by benefiting qi and nourishing blood with strengthening monarch drug in a prescription, and Chinese angelica blood supplementing and blood are acted on, while Radix Astragali, Radix Angelicae Sinensis compatibility with strengthening monarch drug in a prescription, It can play the role of benefiting qi for promoting production of blood.
Further, the Chinese medicine composition is made of the bulk pharmaceutical chemicals comprising following parts by weight：
10~30 parts of cultivated land, 10~30 parts of Chinese yam, 10~30 parts of Fructus Corni,
10~30 parts of Semen Cuscutae, 10~30 parts of the fruit of Chinese wolfberry, 10~30 parts of Radix Astragali, 5~22 parts of Radix Angelicae Sinensis,
10~30 parts of Radix Salviae Miltiorrhizae, 10~30 parts of the radix paeoniae rubrathe, 10~30 parts of the fruit of summer cypress,
10~30 parts of oldenlandia diffusa, 10~30 parts of the root bark of shaggy-fruited dittany.
In Traditional Chinese medicine composition formula of the present invention, on the basis of monarch drug in a prescription, ministerial drug, the connected applications radix paeoniae rubrathe, Radix Salviae Miltiorrhizae, the fruit of summer cypress, Oldenlandia diffusa, the root bark of shaggy-fruited dittany are assistant, then feel evil with treatment void, the accompanying symptoms, the wherein radix paeoniae rubrathe, Radix Salviae Miltiorrhizae heat-clearing solution such as caused itch Poison, promoting blood circulation to remove blood stasis embody the therapy of " control wind and first control blood, blood wind goes out certainly ", and the radix paeoniae rubrathe and Radix Salviae Miltiorrhizae are all clearing heat and detoxicating, promoting blood circulationization The stasis of blood, the two fit applications are good at mutual cooperation and promote external application heat-clearing toxin-expelling functions more prominent；It is the fruit of summer cypress, oldenlandia diffusa, white Fresh hide is clearing heat and detoxicating, dispelling wind and arresting itching.
Further, the proportioning of each bulk pharmaceutical chemicals is preferably in middle pharmaceutical composition：
10~20 parts of cultivated land, 10~20 parts of Chinese yam, 10~20 parts of Fructus Corni,
10~20 parts of Semen Cuscutae, 10~20 parts of the fruit of Chinese wolfberry, 10~20 parts of Radix Astragali, 6~18 parts of Radix Angelicae Sinensis,
10~20 parts of Radix Salviae Miltiorrhizae, 10~20 parts of the radix paeoniae rubrathe, 10~20 parts of the fruit of summer cypress,
10~20 parts of oldenlandia diffusa, 10~20 parts of the root bark of shaggy-fruited dittany.
Traditional Chinese medicine composition formula of the present invention passes through selected allotment, controls the mixing ratio relationship of various Chinese medicine compositions, excellent Change the mutual synergistic application ratio of design various composition so that efficacy of drugs effect collaboration promotion is more prominent outstanding, real Existing good synergistic function.The proportionate relationship of various traditional Chinese medicinal material raw materials pass through preferred design, monarch medicine material into Point can Each performs its own functions, mutually promote and heighten the effect of a treatment, drug total amount is lower, and therapeutic effect is more preferably prominent.
In order to or it is more preferable the effect of the present invention Chinese medicine composition ingredients Ingredient Amount number ratio can also be into One step is preferably following scheme：
Further, 13~18 parts of cultivated land.
Further, 13~18 parts of Chinese yam.
Further, 13~18 parts of Fructus Corni.
Further, 13~18 parts of Semen Cuscutae.
Further, 13~18 parts of the fruit of Chinese wolfberry.
Further, 13~18 parts of Radix Astragali.
Further, Radix Angelicae Sinensis 10-16 parts.
Further, 13~18 parts of Radix Salviae Miltiorrhizae.
Further, 13~18 parts of the radix paeoniae rubrathe.
Further, 13~18 parts of the fruit of summer cypress.
Further, 13~18 parts of oldenlandia diffusa.
Further, 13~18 parts of the root bark of shaggy-fruited dittany.
By the parts by weight ratio relationship of above-mentioned selected every raw medicinal material, a variety of different Chinese medicines can be preferably ensured The mutual mating reaction relationship of material so that Fang Xiezhong is played more for giving full play to expression expected from various medicinal material effects Mutual coordinated effect between kind medicinal material.
Further, the Chinese medicine composition is made of the bulk pharmaceutical chemicals comprising following parts by weight：15 parts of cultivated land, Chinese yam 15 Part, 15 parts of Fructus Corni, 15 parts of Semen Cuscutae, 15 parts of the fruit of Chinese wolfberry, 15 parts of Radix Astragali, 12 parts of Radix Angelicae Sinensis, 15 parts of Radix Salviae Miltiorrhizae, 15 parts of the radix paeoniae rubrathe, summer cypress 15 parts of son, 15 parts of oldenlandia diffusa, 15 parts of the root bark of shaggy-fruited dittany.
Further, externally-applied liniment is made with vegetable oil in the Chinese medicine composition.Preferably, the vegetable oil be rapeseed oil, One or more of peanut oil, sesame oil.Externally-applied liniment is made using vegetable oil etc. as solvent, vegetable oil can be with sterilizing cleaning Vulva, while fully dissolving helps Chinese medicine composition release effective component, vegetable oil is easily affine with skin, and drug is made to go directly disease Institute realizes good therapeutic efficiency effect.
More than prescription on the one hand by drugs such as cultivated land, Chinese yam, dogwood fruit, Semen Cuscutae, the fruit of Chinese wolfberry, Radix Astragali, Radix Angelicae Sinensis, is mended Kidney blood-nourishing, nourish private parts, treat leukoplakia vulvae basic pathogenesis in sheet " void " caused by private parts lose honor caused by private parts bleach, It chaps all diseases；On the other hand it is invigorated blood circulation antipruritic, controlled by the five tastes such as the radix paeoniae rubrathe, Radix Salviae Miltiorrhizae, the fruit of summer cypress, oldenlandia diffusa, root bark of shaggy-fruited dittany drug The diseases such as itch caused by treating the caused heresy of sense repeatedly of mark " reality " in leukoplakia vulvae basic pathogenesis；Furthermore pass through vegetable oil Characteristic gives full play to drug effect.Our treating both manifestation and root cause of disease, it is antipruritic that kidney-replenishing blood-nourishing, promoting blood circulation are played the role of by full side, thoroughly to treat vulva White lesions.
Preferably, liniment is made using sesame oil in the Chinese medicine composition.Sesame oil is both solvent and Chinese medicine composition In raw medicinal material ingredient simply, sesame oil, not only can be while easily affine with skin with help essence and blood, removing toxicity for detumescence to make, and makes Drug guides drugs to illness station.It is antipruritic that kidney-replenishing blood-nourishing, promoting blood circulation are played the role of by full side.
Another object of the present invention is to provide the preparation method of above-mentioned Chinese medicine composition and its administering mode.
A kind of preparation method of above-mentioned Chinese medicine composition：
（1）It weighs each bulk pharmaceutical chemicals to crush respectively, mix；
（2）It is impregnated 20~40 minutes with vegetable oil, 90-102 DEG C is heated 20~40 minutes, is removed slag and is taken supernatant to obtain the final product.
The present invention is using vegetable oil as the Extraction solvent of raw material pharmaceutically active ingredient, while as the figuration of the Chinese medicine composition Agent.The effect of vegetable oil, which has, to be moisturized, and is detoxified, myogenic.Preferably, the vegetable oil is in rapeseed oil, peanut oil, sesame oil It is one or more of.Vegetable oil contains more polyunsaturated fatty acid chain, good fluidity, and the effect for dissolving effective component is also more preferable.Choosing Take vegetable oil impregnate bulk pharmaceutical chemicals, first can promote myogenic, second because it can detoxify, can Rapid reversal itch, be conducive to Drug absorption is restored using promotion.Meanwhile vegetable oil has that boiling point is higher, nontoxic, lubrication, it is and easily special with the affine grade of skin Point contributes to the performance of drug effect.
Further, the vegetable oil is sesame oil.Sesame oil can help essence and blood, removing toxicity for detumescence, the present invention in impregnate drug It chooses " sesame oil ", first because it can be with help essence and blood, the sheet " void " in adjunctive therapy leukoplakia vulvae basic pathogenesis is caused Private parts caused by private parts loses honor bleaches, all diseases of chapping.Second because it can be with removing toxicity for detumescence, adjunctive therapy leukoplakia vulvae is basic The diseases such as itch caused by sense is evil repeatedly caused by mark " reality " in the interpretation of the cause, onset and process of an illness, while vegetable oil has that boiling point is high, nontoxic, lubrication, and appearance Easily with skin it is affine the features such as.
Preferably, step 2, it is heated to 90-102 DEG C using vapor to steam 20-40 minutes, vapor heating has temperature Temperature, the characteristics of being easy to control, the temperature range of heating can be effectively controlled, reach needs steams extraction purpose.
Chinese medicine composition of the present invention, which is recommended to prepare, becomes external preparation, administering mode：External application, before use, warm water cleaning is outer The moon is applied to affected skin, and massaged for a moment in favor of drug absorption, once in the morning and once at night, menstrual period with hand with Chinese medicine composition It is discontinued, medication treatment is made as a treatment course for one month.It embodies《The theoretical parallel prose》：" reason controlled outside, i.e., the interior reason controlled, the medicine controlled outside, The i.e. interior medicine controlled, the different person Fa Er of institute.”
Further, routinely formulation method is prepared into any clinically acceptable drug external application system to the Chinese medicine composition Agent.Can be single formulation drug such as paste, liniment, lotion, paste, gel, plastics, aerosol, spray, tincture, Mixing drug form can be made.
Preferably, the drug external preparation of the Chinese medicine composition is paste, lotion, liniment, spray or gelling agent etc..
Further, purposes of the Chinese medicine composition in prevention or treatment leukoplakia vulvae drug is prepared.
Further, the leukoplakia vulvae is the leukoplakia vulvae that hormone therapy does not tolerate.Preferably, it is described Leukoplakia vulvae refers to the vulvar disease ineffective or invalid to hormone therapy.
Chinese medicine composition of the present invention is preparing the ineffective or invalid leukoplakia vulvae for the treatment of hormone therapy Drug in purposes.
Chinese medicine composition of the present invention can also be applied to prepare the drug for treating other vulva diseases.
Compared with prior art, beneficial effects of the present invention：
The Chinese medicine composition of the present invention, using theory of traditional Chinese medical science as guidance, with reference to the pathogenic characteristic of this disease, in the dialectical base of Traditional Chinese Medicine On plinth, prescription external application without taking orally, directly acts on lesion and plays curative effect, each taste Chinese medicine influences each other, acts synergistically, reaches Kidney-replenishing blood-nourishing, promoting blood circulation itching-relieving action, treating both manifestation and root cause of disease are significant in efficacy.
The Chinese medicine composition of the present invention is by cultivated land, Chinese yam, Fructus Corni, Semen Cuscutae, the fruit of Chinese wolfberry, the radix paeoniae rubrathe, Radix Astragali, Radix Angelicae Sinensis, pellet The common 6-12 tastes Chinese medicine of ginseng, the fruit of summer cypress, oldenlandia diffusa, the root bark of shaggy-fruited dittany is bulk pharmaceutical chemicals, and raw materials used medicine meets Chinese people's republicanism The regulation of state's law of medicine management, nontoxic, no dependence, drug safety is reliable, and cheap, is easily accepted by patients, tool There is vast market prospect.
The present invention is using vegetable oil as the Extraction solvent of raw material pharmaceutically active ingredient, while as the figuration of the Chinese medicine composition Agent.On the one hand, preparation method is easy to operate, and production cost is low, efficient, and production process is environmentally friendly.On the other hand, vegetable oil （Particularly sesame oil）Private parts becomes caused by private parts caused by sheet " void " in adjunctive therapy leukoplakia vulvae basic pathogenesis loses honor In vain, all diseases of chap, while itch caused by sense heresy repeatedly caused by the mark " reality " in adjunctive therapy leukoplakia vulvae basic pathogenesis Wait diseases.Furthermore vegetable oil have boiling point it is high, it is nontoxic, lubricate, and easily with skin it is affine the features such as, contribute to the performance of drug effect.
Chinese medicine composition preparation method of the present invention is easy to operate, production cost is low, efficient, patient user Just.
Specific embodiment
In Chinese medicine composition of the present invention：
Prepared rehmannia root：Latin nameRehmannia glutinosa (Gaetn.) Libosch. ex Fisch. et Mey.Also known as Bosom celebrating glutinous rehmannia, cultivated land.It is sweet in flavor, slightly warm in nature.Return liver and kidney channel.With nourishing yin and supplementing blood, beneficial to spirit and marrow effect.For the deficiency of liver-yin and kidney-yin, waist Knees soreness, osteopyrexia and fever, night sweat seminal emission, Heat Diabetes, blood deficiency chlorosis, palpitation and severe palpitation, irregular menstruation, metrostaxis, dizziness, ear Ring, poliosis.
Chinese yam：Latin nameDioscorea opposite Thunb.Alias RHIIZOMA DIOSCOREAE from Henan of China, Chinese yam rhizome, native potato, sweet potato, sweet potato, Jade prolongs.It is sweet in flavor, it is mild-natured.Returns spleen, lung, kidney channel.With tonifying spleen nourishing the stomach, engender liquid and benefic lung, the puckery essence effect of kidney tonifying.For spleen eating less, Endless diarrhea, the deficiency syndrome of the lung are breathed with cough, emission due to the kidney deficiency, and under band, frequent micturition, abnormal heat is quenched one's thirst.
Fructus Corni：Latin nameCornusofficinalis.Also known as dogwood fruit, cornus.Puckery, acid, slightly warm in nature.Return liver, kidney Through.With tonifying the liver and kidney, puckery essence prevent prolapse acts on.For dizziness and tinnitus, soreness of waist and knee joint, impotence and seminal emission, profuse sweating collapse, interior heat disappears Yearningly.
Semen Cuscutae：Latin nameCuscuta chinensis.Also known as SEMEN CUSCUTAE, without ma rattan, dodder laurel, trailing plants silk.It is sweet in flavor, It is warm-natured.Returns spleen, liver and kidney channel.With nourishing liver and kidney, astringent sperm contracting urine, tocolysis, improving eyesight, anti-diarrhea effect.Have for impotence and seminal emission, urine The heeltap, enuresis frequent micturition, soreness and weakness of waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, fetal irritability, spleen kidney deficiency are rushed down；Externally treating leucoderma.
The fruit of Chinese wolfberry：Latin nameLycium chinense.Also known as lycium barbarum, Ningxia matrimony vine, in peaceful matrimony vine, western matrimony vine.Taste It is sweet；It is mild-natured.Return liver, kidney, lung channel.With nourishing the liver, nourshing kidney, moistening lung effect.For caused by liver and kidney deficiency；It has a dizzy spell；It is visually unclear；Waist Knees soreness；Impotence and seminal emission；Cough due to consumptive disease；It quenches one's thirst and draws drink
Radix Astragali：Latin nameLeguminosae.Also known as astragali or northern alpine yarrow.It is sweet in flavor, slightly warm in nature.Return lung, spleen, liver and kidney channel.With benefit Superficies-consolidating, arrest sweating admittedly take off, torr sore myogenic, inducing diuresis for removing edema effect.For treating treatment deficiency of vital energy weak, the sinking of qi of middle-jiao, rush down prolapse of the anus for a long time is had blood in stool Uterine bleeding, exterior deficiency spontaneous perspiration, ulcer is difficult to burst, burst for a long time and does not holds back, blood deficiency chlorosis, Heat Diabetes.
Radix Angelicae Sinensis：Latin nameAngelica sinensis.Also known as horse hair is returned, cloud is returned, western Radix Angelicae Sinensis, Min Radix Angelicae Sinensis, dry is returned.It is warm-natured, Acrid-sweet flavor.The thoughts of returning home, liver, the spleen channel.With benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturize laxation effect.For irregular menstruation, Amenorrhea abdominal pain, Abdominal mass knot gathers, uterine bleeding；Headache due to deficiency of blood, dizziness, Impotence numbness；Intestines are dry and shit is difficult, weight after dysentery characterized by blood in the stool；Ulcer sores, injury from falling down.
Radix Salviae Miltiorrhizae：Latin nameRadix Salviae Miltiorrhiae.Bitter, micro-pungent, cold nature.The thoughts of returning home, spleen, liver, kidney Through.With promoting blood circulation, nourishing blood and tranquilization, cool blood detumescence effect.For head caused by hemostasis, chest, the side of body, abdomen pain, accumulation, menstruation is not It adjusts, dysmenorrhoea Amenorrhea, postpartum stasis of blood, joint pain is beaten the stasis of blood swell, and warm disease is vexed, palpitation due to deficiency of blood, sore swollen toxin, red rash scabies Tinea.
The radix paeoniae rubrathe：Latin nameRadix Paeoniae Rubra.Also known as wooden Chinese herbaceous peony, red Chinese herbaceous peony, rose glorybower root.Bitter, it is cool in nature. Return liver, the spleen channel.With clearing heat and cooling blood, promoting blood circulation to remove blood stasis effect.For the stagnant Amenorrhea of the stasis of blood, the accumulation of hernia lump in the abdomen, abdominal pain, hypochondriac pain, bleeding from five sense organs or subcutaneous tissue, blood Dysentery, discharging fresh blood stool, hot eyes, carbuncle swells, injury from falling down.
The fruit of summer cypress：Latin nameFructus Kochiae Scopariae.It is cold in nature, acrid flavour, hardship.Also known as ground certain herbaceous plants with big flowers, wheat, fall Broom.With clearing heat and promoting diuresis, dispelling wind and arresting itching effect.For under difficulty and pain in micturition, pruritus vulvae band, rubella, eczema, pruitus.
Oldenlandia diffusa：Latin nameHedyotisdiffusa.Also known as：A, two leaf humulus, brother's dysentery, chun spicebush root, sheep Moss, tang Huang, snakeweed, madder.It is cold in nature, taste is slightly sour.With removing heat from blood, Xiaofeng San gas, removing toxic substances detumescence, analgesic effect.For Lung heat, intestines heat, heat accumulating in the large intestine, laryngalgia, sore swells, snake sore.
The root bark of shaggy-fruited dittany：Latin nameCortex Dictamni.Also known as dittany bark, stereotyped writing ox, seguin argyreia herb, sheep fresh grass.It is cold in nature, taste It is bitter.Returns spleen, stomach, bladder, small intestinl channel.Detoxify with heat-clearing and damp-drying drug, wind-dispelling, insecticidal action.For damp and hot sore, rubella mange, Jaundice, damp and hot numbness pain.
With reference to test example and specific embodiment, the present invention is described in further detail.But this should not be understood Range for the above-mentioned theme of the present invention is only limitted to following embodiment, all to belong to this based on the technology that the content of present invention is realized The range of invention.
<Embodiment 1>
Chinese medicine composition, every part is made of the following raw material medicine：Cultivated land 15g, Chinese yam 15g, Fructus Corni 15g, Semen Cuscutae 15g, matrimony vine Sub- 15g, Radix Astragali 15g, Radix Angelicae Sinensis 12g, Radix Salviae Miltiorrhizae 15g, radix paeoniae rubrathe 15g, fruit of summer cypress 15g, oldenlandia diffusa 15g, root bark of shaggy-fruited dittany 15g.It prepares Method：Above-mentioned raw materials medicinal material is taken, respectively low-temperature grinding, mixing, at normal temperatures plus the sesame oil of 5 times of weight impregnates 30 minutes, water Steam heats（It referred to as steams, similarly hereinafter）It 30 minutes, removes slag and takes supernatant, obtain the smearing external application edible vegetable oil preparation of drug containing.
<Clinical treatment application>
Case is from January, 2008 in December, 2015 in the second affiliated hospital of Chengdu University of Traditional Chinese Medicine department of traditional Chinese medicine outpatient clinic Patient.
Diagnostic criteria：With reference to《New Chinese medicine guideline of clinical investigations》With《Gynecotokology》Formulate diagnostic criteria.
Exclusion criteria：Exclude other vulvas and cervical disease, exclude whole body pathology, for example, tumour, diabetes, itself, exempt from Epidemic disease disease etc..
Meet the patient totally 20, course of disease 1-20 of diagnostic criteria, age 40-65 Sui.
Administering mode and therapy：Before drug, warm water cleaning vulva, with 1 Chinese medicine composition of the embodiment of the present invention It is applied to affected skin, and 3-8min is massaged in favor of drug absorption with hand, once in the morning and once at night.Menstrual period is discontinued.Treatment one Make as a treatment course, three courses for the treatment of observation curative effects of continuous use the moon.
Curative effect determinate standard：
Recovery from illness：Without pruritis, the color and elasticity of skin of vulva mucous membrane restore normal, and hyperplasia/moss sample epidermis disappears；
Effectively：Pruritis mitigates, and accumulation range is obviously reduced, color perfecting, subtracts before other related symptoms and sign relatively treatment Gently；
In vain：Itch, color and extent of disease are not all obviously improved.
Treatment results：
The patient of 20 leukoplakia vulvaes is after the Chinese medicinal liniment for giving the preparation of embodiment 1, and keeping under strict supervision close inspection patient is according to specification Treatment is administered, follow-up result is as follows：
It after three course of therapy, fully recovers 9, improves 10, invalid 1, total effective rate is up to 95%.Patient is without any bad anti- Should, three big routines and hepatic and renal function detection are no abnormal.
<Model case>
Traditional Chinese medicine composition for treating model case 1
King XX, female 60 years old, go to a doctor in March, 2008, pruritus vulvue 6 years or more, and because of scratching, many places scratch, red occurs in vulva Swollen, a small amount of bleeding, and skin color bleaches.Patient is ineffective using glucocorticoid treatment in locality, using of the invention real Example 4 Chinese medicine composition external application, three courses for the treatment of are applied, clinical symptoms completely disappear, and follow-up in 1 year is not recurred.
Traditional Chinese medicine composition for treating model case 2
All XX, female 55 years old, go to a doctor in April, 2009, pruritus vulvue 4 years or more, when have scorching hot, feeling of pain, in locality, medical treatment makes Invalid with external application corticosteroid drug, pathologic finding makes a definite diagnosis kraurosis vulcae.Patient is used outside 5 Chinese medicine preparation of the embodiment of the present invention With three courses for the treatment of, clinical symptoms completely disappear, and follow-up in 1 year is not recurred.
Traditional Chinese medicine composition for treating model case 3
Hu XX, female 53 years old, go to a doctor in June, 2010, pruritus vulvue, and when has scorching hot, and pars affecta skin is coarse, bleaches, and has chap. Ineffective with hormone Prednisone Therapy in locality, pathologic finding makes a definite diagnosis this disease.Patient uses 8 Chinese medicine preparation of the embodiment of the present invention Three courses for the treatment of of external application, clinical symptoms completely disappear, and follow-up in 1 year is not recurred.
<Embodiment 2>
Chinese medicine composition is made of following raw material medicine：Cultivated land 15g, fruit of Chinese wolfberry 15g, Radix Astragali 15g, Radix Angelicae Sinensis 12g, Radix Salviae Miltiorrhizae 15g, fruit of summer cypress 15g, root bark of shaggy-fruited dittany 15g.
Preparation method：Above-mentioned raw materials medicinal material is taken, respectively low-temperature grinding, mixing adds the sesame oil immersion of 5 times of weight at normal temperatures Bubble 30 minutes steams 30 minutes, removes slag and take supernatant, obtain the external application edible vegetable oil preparation of drug containing.
Screening meets《Gynecotokology》The patient of diagnostic criteria is formulated, gives the preparation for impregnating this sesame oil, is accused Know that medication according to the same manner as in Example 1 is treated, continuously treat 3 courses for the treatment of.Treatment results：10 leukoplakia vulvaes Patient fully recovers 3 after three course of therapy, improves 6, invalid 1, and total effective rate is up to 90%.Patient is without any bad anti- Should, three big routines and hepatic and renal function detection are no abnormal.
<Embodiment 3>
On the basis of embodiment 1 prepares Chinese medicine composition, research is improved, is proposed made of following raw material medicine Chinese medicine composition：Cultivated land 15g, Chinese yam 15g, Fructus Corni 15g, Semen Cuscutae 15g, fruit of Chinese wolfberry 15g, Radix Astragali 15g, Radix Angelicae Sinensis 12g, Radix Salviae Miltiorrhizae 15g, fruit of summer cypress 15g, root bark of shaggy-fruited dittany 15g.
Preparation method：Above-mentioned raw materials medicinal material is taken, respectively low-temperature grinding, mixing adds the sesame oil immersion of 4 times of weight at normal temperatures Bubble 25 minutes steams 35 minutes, removes slag and take supernatant, obtain the external application edible vegetable oil preparation of drug containing.
Screening meets《Gynecotokology》The patient of diagnostic criteria is formulated, gives the preparation for impregnating this sesame oil, is accused Know that medication according to the same manner as in Example 1 is treated, continuously treat 3 courses for the treatment of.Treatment results：10 leukoplakia vulvaes Patient fully recovers 4 after three course of therapy, improves 5, invalid 1, total effective rate about 90%.Patient is without any bad anti- Should, three big routines and hepatic and renal function detection are no abnormal.
<Embodiment 4>
Chinese medicine composition is made of the following raw material medicine：Cultivated land 12g, Chinese yam 15g, Fructus Corni 10g, Semen Cuscutae 10g, the fruit of Chinese wolfberry 10g, Radix Astragali 10g, Radix Angelicae Sinensis 6g, Radix Salviae Miltiorrhizae 10g, radix paeoniae rubrathe 10g, fruit of summer cypress 10g, oldenlandia diffusa 10g, root bark of shaggy-fruited dittany 10g.
Preparation method crushes respectively for above-mentioned raw materials medicine, mixes, at normal temperatures mixing plus 5 times of vegetable seed oil immersions by weight ratio Bubble 30 minutes, steam heating contain the rapeseed oil 30 minutes immersed with Chinese medicine, remove slag and take supernatant, the external application for obtaining drug containing is clear Oil formulation.
<Embodiment 5>
Chinese medicine composition is made of the following raw material medicine：Cultivated land 20g, Chinese yam 30g, Fructus Corni 22g, Semen Cuscutae 30g, the fruit of Chinese wolfberry 12g, Radix Astragali 15g, Radix Angelicae Sinensis 15g, Radix Salviae Miltiorrhizae 15g, radix paeoniae rubrathe 30g, fruit of summer cypress 30g, oldenlandia diffusa 30g, root bark of shaggy-fruited dittany 30g.
Preparation method crushes respectively for above-mentioned raw materials medicine, mixes, and mixes the sesame for adding 5 times of weight by weight ratio at normal temperatures Sesame oil impregnates 30 minutes, is heated to 99 DEG C, keeps the temperature 30 minutes, removes slag and take supernatant, obtain the external application edible vegetable oil preparation of drug containing.
<Embodiment 6>
Take cultivated land 15g, Chinese yam 20g, Fructus Corni 20g, Semen Cuscutae 15g, fruit of Chinese wolfberry 12g, Radix Astragali 15g, Radix Angelicae Sinensis 10g, Radix Salviae Miltiorrhizae 10g, Radix paeoniae rubrathe 30g, fruit of summer cypress 10g, oldenlandia diffusa 15g, root bark of shaggy-fruited dittany 10g are uniformly mixed.Add in the peanut oil of 1.5 times of weight, dipping It 40 minutes, after heating steams 25 minutes, removes slag and takes supernatant spare.
Separately stearic acid, atoleine, lanolin is taken to be heated to melting in a water bath, continue to be heated to 75 DEG C；Separately by three ethyl alcohol Amine, methyl hydroxybenzoate and distilled water 25ml, are heated to 75 DEG C, slowly pour into the mixtures such as stearic acid, with adding with stirring, add After continue stirring to 40 DEG C to get emulsifiable paste matrix.Above-mentioned supernatant is added in appropriate emulsifiable paste matrix, is stirred to get this product.
<Embodiment 7>
Take cultivated land 20g, Chinese yam 10g, Fructus Corni 15g, Semen Cuscutae 20g, fruit of Chinese wolfberry 12g, Radix Astragali 10g, Radix Angelicae Sinensis 15g, Radix Salviae Miltiorrhizae 20g, Radix paeoniae rubrathe 10g, fruit of summer cypress 10g, oldenlandia diffusa 15g, root bark of shaggy-fruited dittany 10g are uniformly mixed.Add in 2 times of weight ratio rapeseed oils, dipping 22 Minute, after heating steams 35 minutes, remove slag and take supernatant spare.
Separately stearic acid, atoleine, lanolin is taken to be heated to melting in a water bath, continue to be heated to 78 DEG C；Separately by three ethyl alcohol Amine, methyl hydroxybenzoate and distilled water 25ml, are heated to 80 DEG C, slowly pour into the mixtures such as stearic acid, with adding with stirring, add After continue stirring to 45 DEG C to get emulsifiable paste matrix.Above-mentioned supernatant is added in appropriate emulsifiable paste matrix, is stirred to get this product.
<Embodiment 8>
Take cultivated land 20g, Chinese yam 10g, Fructus Corni 20g, Semen Cuscutae 15g, fruit of Chinese wolfberry 10g, Radix Astragali 20g, Radix Angelicae Sinensis 15g, Radix Salviae Miltiorrhizae 10g, Radix paeoniae rubrathe 10g, fruit of summer cypress 10g, oldenlandia diffusa 15g, root bark of shaggy-fruited dittany 15g are uniformly mixed.Add in 1.75 times of weight sesame oil, dipping It 30 minutes, after heating steams 35 minutes, removes slag and takes supernatant spare.
Separately stearic acid, atoleine, lanolin is taken to be heated to melting in a water bath, continue to be heated to 75 DEG C；Separately by three ethyl alcohol Amine, methyl hydroxybenzoate and distilled water 25ml, are heated to 75 DEG C, slowly pour into the mixtures such as stearic acid, with adding with stirring, add After continue stirring to 42 DEG C to get emulsifiable paste matrix.Above-mentioned supernatant is added in appropriate emulsifiable paste matrix, is stirred to get this product.
<Embodiment 9>
Take cultivated land 15g, Chinese yam 14g, Fructus Corni 18g, Semen Cuscutae 15g, fruit of Chinese wolfberry 10g, Radix Astragali 15g, Radix Angelicae Sinensis 12g, Radix Salviae Miltiorrhizae 10g, Radix paeoniae rubrathe 15g, fruit of summer cypress 20g, oldenlandia diffusa 10g, root bark of shaggy-fruited dittany 12g are uniformly mixed.The sesame oil of 2 weight is added in, impregnates 30 points Clock after heating steams 30 minutes, removes slag and takes supernatant spare.
Separately stearic acid, atoleine, lanolin is taken to be heated to melting in a water bath, continue to be heated to 75 DEG C；Separately by three ethyl alcohol Amine, methyl hydroxybenzoate and distilled water 25ml, are heated to 75 DEG C, slowly pour into the mixtures such as stearic acid, with adding with stirring, add After continue stirring to 43 DEG C to get emulsifiable paste matrix.Above-mentioned supernatant is added in appropriate emulsifiable paste matrix, is stirred to get this product.
<Embodiment 10>
According to 3 composition of raw materials ratio of embodiment, raw material is weighed, the 90v% ethanol waters for adding in 3 times of weight carry out refluxing extraction, Extraction 3 times is repeated, extracts 3h, 1h, 1h respectively, merges extraction solution, recycles ethyl alcohol, be concentrated into every 1mL and correspond to 3g raw medicinal herbs, use Dimethyl ether is configured to content of dispersion 6.75wt% sprays.
<Embodiment 11>
Traditional Chinese medicine composite ingredient according to the medicinal material formula rate of embodiment 9 is weighed, is shredded, with 80v% alcohol refluxs Extraction obtains effective component, concentrates, and adds in common drug auxiliary material poloxamer188, PLURONICS F87, glycerine, ethylparaben And water, corresponding exterior-applied gel is made.
<Embodiment 12>
Traditional Chinese medicine composite ingredient according to the medicinal material formula rate of embodiment 9 is weighed, is shredded, with 80v% alcohol refluxs Extraction obtains effective component, concentrates, and adjusts pH=6-8, adds water, 1000mL traditional Chinese medicine lotions are obtained by filtration.
<Embodiment 13>
Traditional Chinese medicine composite ingredient according to the medicinal material formula rate of embodiment 9 is weighed, is shredded, tea oil immersion is added in and floods Not yet, it impregnates 5 days at 40-50 DEG C, filters while hot（300 mesh sieve）, filtrate let cool to room temperature, then with 400 mesh screens, and filtrate adds Tea oil is settled to 400mL to get liniment.

Claims (10)

1. a kind of Chinese medicine composition, which is characterized in that be made of the bulk pharmaceutical chemicals comprising following parts by weight：
10~30 parts of cultivated land, 10~30 parts of the fruit of Chinese wolfberry, 10~30 parts of Radix Astragali, 5~22 parts of Radix Angelicae Sinensis,
10~30 parts of Radix Salviae Miltiorrhizae, 10~30 parts of the fruit of summer cypress, 10~30 parts of the root bark of shaggy-fruited dittany.
2. Chinese medicine composition as described in claim 1, which is characterized in that the Chinese medicine composition, by including following parts by weight Bulk pharmaceutical chemicals be made：
10~30 parts of cultivated land, 10~30 parts of Chinese yam, 10~30 parts of Fructus Corni,
10~30 parts of Semen Cuscutae, 10~30 parts of the fruit of Chinese wolfberry, 10~30 parts of Radix Astragali, 5~22 parts of Radix Angelicae Sinensis,
10~30 parts of Radix Salviae Miltiorrhizae, 10~30 parts of the fruit of summer cypress, 10~30 parts of the root bark of shaggy-fruited dittany.
3. Chinese medicine composition as claimed in claim 2, which is characterized in that the middle pharmaceutical composition, by including following weight The bulk pharmaceutical chemicals of part are made：
10~30 parts of cultivated land, 10~30 parts of Chinese yam, 10~30 parts of Fructus Corni,
10~30 parts of Semen Cuscutae, 10~30 parts of the fruit of Chinese wolfberry, 10~30 parts of Radix Astragali, 5~22 parts of Radix Angelicae Sinensis,
10~30 parts of Radix Salviae Miltiorrhizae, 10~30 parts of the radix paeoniae rubrathe, 10~30 parts of the fruit of summer cypress,
10~30 parts of oldenlandia diffusa, 10~30 parts of the root bark of shaggy-fruited dittany.
4. Chinese medicine composition as claimed in claim 3, which is characterized in that the Chinese medicine composition, by including following parts by weight Bulk pharmaceutical chemicals be made：
10~20 parts of cultivated land, 10~20 parts of Chinese yam, 10~20 parts of Fructus Corni, 10~20 parts of Semen Cuscutae,
10~20 parts of the fruit of Chinese wolfberry, 10~20 parts of Radix Astragali, 6~20 parts of Radix Angelicae Sinensis, 10~20 parts of Radix Salviae Miltiorrhizae,
10~20 parts of the radix paeoniae rubrathe, 10~20 parts of the fruit of summer cypress, 10~20 parts of oldenlandia diffusa, 10~20 parts of the root bark of shaggy-fruited dittany.
5. routinely formulation method is prepared into and any can clinically connect Chinese medicine composition as described in claim any one of 1-4 The drug external preparation received.
6. drug external preparation as claimed in claim 5 is paste, lotion, liniment, spray or gelling agent.
7. the preparation method of any one of the claim 1-4 Chinese medicine compositions：
（1）It weighs each bulk pharmaceutical chemicals to crush respectively, mix；
（2）It is impregnated 20~40 minutes with vegetable oil, 90-102 DEG C is heated 20~40 minutes, is removed slag and is taken supernatant to obtain the final product.
8. preparation method as claimed in claim 7, which is characterized in that the vegetable oil is sesame oil.
9. use of the Chinese medicine composition in prevention or treatment leukoplakia vulvae drug is prepared as described in claim any one of 1-4 On the way.
10. purposes as claimed in claim 9, which is characterized in that the leukoplakia vulvae refers to hormone therapy effect not Good or invalid vulvar disease.
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108969697A (en) * 2018-08-31 2018-12-11 河南科大外阴白斑研究院有限公司 A kind of pharmaceutical formulation that treating leukoplakia vulvae and its preparation process

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101637540A (en) * 2008-07-30 2010-02-03 高光 Chinese medicament for treating ichthyosis
CN105560842A (en) * 2016-03-28 2016-05-11 姜群群 Traditional Chinese medicine preparation for treating leucoderma caused by liver and kidney deficiency and wind-damp collateral blockage

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101637540A (en) * 2008-07-30 2010-02-03 高光 Chinese medicament for treating ichthyosis
CN105560842A (en) * 2016-03-28 2016-05-11 姜群群 Traditional Chinese medicine preparation for treating leucoderma caused by liver and kidney deficiency and wind-damp collateral blockage

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
谢普: "《验方新编》", 30 April 2017, 中医古籍出版社 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108969697A (en) * 2018-08-31 2018-12-11 河南科大外阴白斑研究院有限公司 A kind of pharmaceutical formulation that treating leukoplakia vulvae and its preparation process
CN108969697B (en) * 2018-08-31 2021-06-18 河南科大外阴白斑研究院有限公司 Medicine formula for treating leukoplakia vulvae and preparation process thereof

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