CN108186097A - Magnesium alloy bone plate and production method - Google Patents
Magnesium alloy bone plate and production method Download PDFInfo
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- CN108186097A CN108186097A CN201810011284.2A CN201810011284A CN108186097A CN 108186097 A CN108186097 A CN 108186097A CN 201810011284 A CN201810011284 A CN 201810011284A CN 108186097 A CN108186097 A CN 108186097A
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- bone plate
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- 210000000988 bone and bone Anatomy 0.000 title claims abstract description 74
- 229910000861 Mg alloy Inorganic materials 0.000 title claims abstract description 47
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 11
- 238000000576 coating method Methods 0.000 claims abstract description 36
- 239000011248 coating agent Substances 0.000 claims abstract description 35
- 239000011159 matrix material Substances 0.000 claims abstract description 33
- CPKVUHPKYQGHMW-UHFFFAOYSA-N 1-ethenylpyrrolidin-2-one;molecular iodine Chemical compound II.C=CN1CCCC1=O CPKVUHPKYQGHMW-UHFFFAOYSA-N 0.000 claims abstract description 20
- 229920000153 Povidone-iodine Polymers 0.000 claims abstract description 20
- 229960001621 povidone-iodine Drugs 0.000 claims abstract description 20
- 239000000956 alloy Substances 0.000 claims abstract description 8
- 238000010288 cold spraying Methods 0.000 claims abstract description 7
- 238000000034 method Methods 0.000 claims description 19
- 239000007789 gas Substances 0.000 claims description 14
- 239000007921 spray Substances 0.000 claims description 14
- 238000005507 spraying Methods 0.000 claims description 11
- 238000007788 roughening Methods 0.000 claims description 10
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 8
- 229910052749 magnesium Inorganic materials 0.000 claims description 8
- 239000011777 magnesium Substances 0.000 claims description 8
- 239000000843 powder Substances 0.000 claims description 8
- 238000010008 shearing Methods 0.000 claims description 4
- 238000005488 sandblasting Methods 0.000 claims description 3
- 238000004140 cleaning Methods 0.000 claims description 2
- 239000011261 inert gas Substances 0.000 claims description 2
- 238000005498 polishing Methods 0.000 claims description 2
- 238000000926 separation method Methods 0.000 claims description 2
- 239000004576 sand Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 22
- 238000002360 preparation method Methods 0.000 abstract description 5
- 230000015572 biosynthetic process Effects 0.000 abstract description 2
- 229940079593 drug Drugs 0.000 description 15
- 239000000463 material Substances 0.000 description 9
- 210000005069 ears Anatomy 0.000 description 6
- 239000010410 layer Substances 0.000 description 6
- 230000008569 process Effects 0.000 description 6
- 229910001069 Ti alloy Inorganic materials 0.000 description 5
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 3
- 102000001999 Transcription Factor Pit-1 Human genes 0.000 description 3
- 108010040742 Transcription Factor Pit-1 Proteins 0.000 description 3
- 238000003491 array Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 239000010936 titanium Substances 0.000 description 3
- 229910052719 titanium Inorganic materials 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 2
- 230000007797 corrosion Effects 0.000 description 2
- 238000005260 corrosion Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000009713 electroplating Methods 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 238000007747 plating Methods 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 208000010392 Bone Fractures Diseases 0.000 description 1
- 206010068052 Mosaicism Diseases 0.000 description 1
- 239000006004 Quartz sand Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000011247 coating layer Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-M iodide Chemical compound [I-] XMBWDFGMSWQBCA-UHFFFAOYSA-M 0.000 description 1
- 229940006461 iodide ion Drugs 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000010453 quartz Substances 0.000 description 1
- 210000003765 sex chromosome Anatomy 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 238000007910 systemic administration Methods 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/80—Cortical plates, i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/02—Inorganic materials
- A61L31/022—Metals or alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medical Informatics (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention discloses a kind of magnesium alloy bone plate and production method, wherein magnesium alloy bone plate includes the plate body for being provided at least two bone screw holes, the povidone iodine coating that the plate body includes the matrix of magnesium alloy material and formed in matrix surface cold spraying.Bone plate density and elasticity according to the present invention is closer with natural bone, and coating is simpler compared to coating preparation method, it is easier to which thickness is given needed for formation puts medicine layer.
Description
Technical field
The present invention relates to a kind of magnesium alloy bones plate, and the invention further relates to a kind of production methods of the magnesium alloy bone plate.
Background technology
For internal fixation material used in clinic often based on titanium alloy material, which has excellent corrosion resistant at present
Corrosion energy and mechanical property, but its biocompatibility is poor, and expensive, density and elasticity differ larger with natural bone, easily
Stress shielding phenomenon is caused, influence the growth of bone tissue and extends healing time.
In addition, interior fixed implanted medical device usually induces the generation of infection, lead to operative failure, severe patient leads to limbs
Lose or even threat to life, and if Formulations for systemic administration, there are affected area drug concentration is too low, to liver, kidney, ear etc. other
There are the risks of latent lesion for histoorgan.Therefore, it is current more commonly used way to carry out putting medicine on such as bone plate.
Such as Chinese patent literature CN204562348U, setting load drug hole and load drug reservoir, profit on bone plate ontology
With carrying drug hole and carrying a certain amount of drug of drug storage function storage of drug reservoir, so as to promote the reparation of bone.However, although this
Kind mode solves the problems, such as drug storage, but the setting of load drug hole and load drug reservoir can make the shearing resistance section factor of bone plate ontology
It changes, and stress concentration can be generated in the place for being provided with hole or slot, and influence the overall mechanical properties of bone plate.
In addition, carry drug hole and carry drug reservoir no matter be distributed how uniformly, can not all accomplish really uniformly, drug only can be from example
As tapered at hole to extracellular concentration.
In view of this, can the prepares coating on bone plate or it is other kinds of put medicine layer by way of solve synthetism
The problem of onboard medicine uniformity, such as Chinese patent literature CN102416202A, to the synthetism using titanium and titanium alloy as ontology
Plate carries out anodized in electrolyte containing Iodophor, and surface forms one layer containing iodine, high adherency, porous anodic oxidation
Film, so as to obtain anti-microbial property.Its antibacterial mechanisms is that anode oxide film can be with slow release iodide ion, so as to effectively inhibit material
Surrounding and the bacterial reproduction on surface.Using titanium or titanium alloy as matrix, as previously mentioned, can there are of high cost, density be elasticity with
Natural bone differs bigger situation.And based on plating, it is relative complex from the point of view of technological angle, and with the deposition of coating,
Plating process can be suppressed, and can not often obtain relatively thick coating in a relatively short period of time.
Invention content
The purpose of the present invention is to provide a kind of magnesium alloy bone plate for being loaded with povidone iodine coating, the bone plate density and
Elasticity is closer with natural bone, and coating is simpler compared to coating preparation method, it is easier to thickness is given needed for formation
Put medicine layer.The present invention also provides a kind of preparation methods of magnesium alloy bone plate.
Embodiment according to the present invention provides a kind of magnesium alloy bone plate, the plate body including being provided at least two bone screw holes,
The povidone iodine coating that the plate body includes the matrix of magnesium alloy material and formed in matrix surface cold spraying.
Above-mentioned magnesium alloy bone plate, optionally, plate body is bar part, and otic placode is equipped on the both sides of bar part；
Bone screw holes include being arranged on the end bone screw holes at plate body both ends and the side seam nail hole being arranged on otic placode.
Optionally, in the length direction of plate body, side seam nail hole is arranged alternately successively on the both sides of plate body.
Optionally, multiple pit arrays are formed in plate body front and back.
Optionally, auxiliary hole is provided between adjacent pit array, for adjusting the shearing resistance section factor of plate body in the longitudinal direction.
Optionally, the auxiliary hole between adjacent pit array is a pair, and corresponding two auxiliary hole separations are in plate body length direction
The both sides of section.
Optionally, pit array is line-column matrix；
Pit depth is not more than 1/7th of plate body plate thickness, and not less than 1/10th of plate body plate thickness；
Pit bore is 1.5 ~ 2.5 times of pit depth.
Embodiment according to the present invention additionally provides a kind of production method of aforementioned magnesium alloy bone plate, the production method
Include the following steps：
1）Pretreatment：Surface polishing, cleaning are carried out, and then dry to the matrix of given magnesium alloy material, then to matrix into
The roughening treatment of row surface；
2）Spraying：Using cold spraying method, granularity is sprayed into matrix surface for 80-150 μm of povidone iodine and forms coating.
Above-mentioned production method, optionally, the surface roughening treatment to matrix are at the sandblasting roughening using 50 mesh quartz sands
Reason.
Optionally, inert gas is used during spraying as working gas, and by adjusting air pressure and powder feeding pressure
Power and the mode of spray distance obtain the coating of different-thickness.
Embodiment according to the present invention substitutes titanium or titanium alloy using magnesium alloy, and the density of pure magnesium is 1.74g/cm3,
Be in all metals with skeleton density（Generally 1.75 g/cm3）Immediate metal.The elasticity modulus of magnesium alloy is about
Twice of skeleton less than the half of titanium alloy, is more nearly with the elasticity modulus of skeleton, being capable of effective link stress
Occlusion effect.In biomethanics, magnesium alloy is best suited for the material as bone plate.
In addition, magnesium is one of element needed by human, as long as controlling the degradation speed of magnesium alloy bone plate in kidney generation
Within the scope of thanking to ability, sex chromosome mosaicism safe to use would not be generated.It should be noted that used magnesium closes in the present invention
Gold is medical magnesium alloy, and mainly including WE43, AZ31, Mg-Ca, MgZnCa, engineering properties is also all relatively.
In an embodiment of the present invention, also there is a povidone iodine in the surface spraying using magnesium or magnesium alloy as matrix, and shape
Into coating, coating layer thickness can be adjusted according to process conditions, be limited in itself by technique smaller, however, it would be possible to be molded
The coating of required various thickness, technological flexibility are more preferable.
And povidone iodine is a kind of disinfection sanitizer of wide spectrum, the sterilizing of povidone iodine and the sustained release of magnesium alloy can be with
Respectively play respective advantage.In addition, it is to compare to can adapt to spray in disinfection sanitizer to screen povidone iodine by inventor
The drug of technique, cold spray process are also smaller to the detraction of medicine effect.
Description of the drawings
Fig. 1 is magnesium alloy bone plate dimensional structure diagram in an embodiment.
Fig. 2 is a kind of magnesium alloy bone plate main structure diagram.
Fig. 3 is the A-A sectional views of Fig. 2.
Fig. 4 is the B-B sectional views of Fig. 2.
Fig. 5 is the I portions enlarged drawing of Fig. 3.
Fig. 6 is the II portions enlarged drawing of Fig. 4.
Fig. 7 is a kind of backsight structural representation of magnesium alloy bone plate.
In figure：1. plate body, 2. back side pits, 3. auxiliary holes, 4. end bone screw holes, 5. pick up the ears, 6. side mounting holes, 7. counterbores, and 8.
Front pit.
11. matrix, 12. coatings.
Specific embodiment
Embodiment according to the present invention is further processed using conventional magnesium alloy bone plate as matrix 11, is accepted
Aforementioned content, magnesium alloy herein is the magnesium alloy for being capable of bearing bone plate, belongs to one kind of medical magnesium alloy, about matrix
11 components made of known elements or known material, additional say no longer is carried out for material in the present invention in itself
It is bright.
On magnesium alloy bone plate shown in Fig. 1, elongate in shape is about, and with certain curvature, the curvature table
Now on the face perpendicular with the length direction of elongate in shape, generally it is used to match the structure of bone contours physiological camber.
Several bone screw holes are provided on the plate body 1 of bone plate shown in Fig. 1, had both been included positioned at the end at bone plate both ends in figure
Bone screw holes 4 also include the side seam nail hole 6 positioned at bone plate both sides, for fixation of the plate body 1 on bone.
Wherein plate body 1 is equivalent on traditional magnesium or the bone plate of magnesium alloy material and increases a figure layer, such as
Shown in Figures 5 and 6, povidone iodine coating is formed by cold spray process in magnesium or the matrix of magnesium alloy material 11, i.e., shown in figure
Coating 12.
Cold spray process is different from electroplating technology, and electroplating technology is with the thickening of coating, by coating material and basic material
The difference of property, it is difficult to accomplish that comparison is thick that can lead to coating.And cold spray process is then different, the compatibility of institute's coating materials itself
More preferably, it is easily formed relatively thick stenlizing layer.And the speed of cold spraying is related with the technological parameter of cold spraying, with matrix 11
Property relationship it is little.
Povidone iodine belongs to wide spectrum disinfective agent, and can be sustained in the coating, therefore, according to its slow releasing function,
The coating to form given thickness can be sprayed, to adapt to the different courses for the treatment of.
Referring to Figure of description 1 ~ 3 and 7, as it can be seen that the main outline of plate body 1 is bar part, in its length direction in figure
Both sides are set there are four picking up the ears 5, and are picking up the ears to be provided with side seam nail hole 6 on 5.
Visible in fig. 2, the presence of side seam nail hole 6 can be distributed in the pit on 1 surface of plate body, such as 2 He of back side pit
Front pit 8 is distributed relatively uniform, i.e., does not influence it and put medicine.
In addition, 5 being extended outwardly certain distance by picking up the ears, plate body 1 has relatively large equivalent span, fixation
Property can be more preferable.
It is directly opened on strip structure part if located in the side seam nail hole 6 of 1 side of plate body, to meet preferable fixed effect
Fruit needs to be adapted to the larger width of plate body 1, causes larger to bone covering surface area, and influences blood fortune.
By 5 width for extending outwardly certain distance rather than the entire plate body 1 of increase of picking up the ears, in the condition for saving materials
Under, the negative effect restored to bone is also relatively small.
Further, referring to Figure of description 2, can clearly find out in attached drawing 2, side seam nail hole 6 there are 4, but in horizontal stroke
To, the two not on a same row, but the certain distance that is staggered, be equivalent to side seam nail hole 6 and adopted in the longitudinal direction on plate body 1
It sets with the following methods：
One side seam nail hole 6 is set in side, one is set to the opposite side of plate body at set a distance 1 on 1 length direction of plate body
Side seam nail hole 6, and so on, generate the situation that side seam nail hole 6 is alternately present successively on the both sides of plate body 1.
Thus, the bone screw holes of side, are in triangular distribution with opposite side between bone screw holes adjacent thereto, Neng Gouman
The fixed reliability of foot, and in contrast, it is possible to reduce the open cell content of bone screw holes.
Merely with regard to attached drawing 2 from the point of view of, four side seam nail hole 6 are equivalent to four rows, according to traditional boring method, every row are needed to have
A pair, and in fig. 2, then every row one is equivalent to, reduces open cell content, difficulty of processing reduces, and decreases useful to plate body 1
The occupancy of area.
In addition, by the way of picking up the ears 5 to set side seam nail hole 6, reduce the contact area of plate body and bone, to bone
The blood fortune of bone influences smaller.
Further, as shown in Figures 2 and 4, multiple pit arrays are formed in 1 front and back of plate body, as shown in FIG.
Back side pit 2 and front pit 8, the presence of pit on the one hand can reduce the contact area of plate body 1 and bone, with reduction pair
The influence of blood fortune.On the other hand, the presence of pit can increase the area of spraying, be conducive to deposit more povidone iodine.
All it is line-column matrix as it can be seen that pit has multiple arrays in the structure shown in Fig. 1,2 and 7, between adjacent pit array
Auxiliary hole 3 is provided with, for adjusting the shearing resistance section factor of plate body 1 in the longitudinal direction, to reduce stress concentration, is mitigated to plate body 1
The influence of integral strength.
Auxiliary hole 3 is a pair between adjacent pit array, and corresponding two auxiliary holes 3 are lived apart in 1 length direction midship section of plate body
Both sides.
Auxiliary hole 3 is through-hole, can reduce difficulty of processing, single side time processing.
For pit, as previously mentioned, it is needed with certain aperture, to reduce the influence that plate body 1 transports blood, and its
Certain depth is needed to have, a certain amount of povidone iodine can be accommodated.One opposite factor is that pit depth is not easy to
It is excessive, it crosses conference and generates bigger flow resistance, spraying is also sprayed less than bottom hole, is acted on without practical receiving.And pit depth
Crossing conference causes the strength reduction of plate body 1 larger, to sum up considerations above, and pit depth is not more than 1/7th of plate body plate thickness,
And not less than 1/10th of plate body plate thickness.
And for pit bore, it is 1.5 ~ 2.5 times of pit depth.
Pit, back side pit 2 and front pit 8 as shown in Fig. 1,2 and 4, are all circular pits.
In addition, as shown in figure 4, the bore in the relative aperture front awkward-sounding 8 of back side pit 2 is big, on the one hand for arcuate structure
Plate body 1, the back side have larger area, are also suitable for out larger pit, and on the other hand, the back side is not directly contacted with bone,
With larger slow-release capability, therefore thicker coating 12 and the larger accommodating ability to drug can be adapted to.
About magnesium alloy bone plate, mainly Degradable bone fracture plate, therefore, the nail being adapted to also uses degradable bone
Nail, from without taking out bone plate by second operation.
To the embodiment of magnesium alloy bone plate making side：
Embodiment 1：
The matrix 11 of magnesium alloy bone plate is pre-processed first, is mainly polished the surface of matrix 11, cleaned simultaneously
Then drying carries out roughening treatment, to improve the bond strength of coating 12 and matrix 11 to matrix 11.
Roughening treatment is that 11 surface of matrix uses granularity to carry out sandblasting roughening treatment for the quartz sand of 50 mesh.
Followed by the matrix 11 after roughening treatment is sprayed：Using cold spray technique by particle diameters be 80 μm
Povidone iodine spray to the surface of matrix 11, can prepare and be loaded with povidone iodine coating magnesium alloy bone plate.
The technological parameter of spraying is：Working gas and powder feeding gas are N2, wherein air pressure and powder feeding gas
Pressure is respectively 1MPa and 1.5MPa, and working gas temperature is 100 DEG C, spray distance 20mm.
Thicknesses of layers, suppressed zero before measurement are measured using TT260 coating thickness detectors.6 are equably selected in specimen surface
A test point, the thickness value averaged as coating 12, it is 300 μm to measure thickness.
Embodiment 2：
11 surface of matrix is pre-processed using method same as Example 1.
The povidone iodine that particle diameters are 120 μm is sprayed into 11 surface of matrix using cold spray technique, it can
Preparation is loaded with povidone iodine coating magnesium alloy bone plate.
The technological parameter of spraying is：Working gas and powder feeding gas are N2, wherein air pressure and powder feeding gas
Pressure is respectively 1.5MPa and 2MPa, and working gas temperature is 150 DEG C, spray distance 25mm.
Identical method is used to measure the thickness of coating 12 as 436 μm.
Embodiment 3：
Plate surface is pre-processed using method same as Example 1.
The povidone iodine that particle diameters are 150 μm is sprayed into 11 surface of matrix using cold spray technique, it can
Preparation is loaded with povidone iodine coating magnesium alloy bone plate.
The technological parameter of spraying is：Working gas and powder feeding gas are N2, wherein air pressure and powder feeding gas
Pressure is respectively 2MPa and 2.5MPa, and working gas temperature is 200 DEG C, spray distance 30mm.
Identical method is used to measure the thickness of coating 12 as 527 μm.
In conclusion by adjusting the technological parameter of spraying, the coating 12 of different thickness, technological flexibility ratio can be obtained
Preferably.
Claims (10)
1. a kind of magnesium alloy bone plate, the plate body including being provided at least two bone screw holes, which is characterized in that the plate body includes magnesium
Or magnesium alloy material matrix and matrix surface cold spraying formed povidone iodine coating.
2. magnesium alloy bone plate according to claim 1, which is characterized in that plate body is bar part, in bar part
Both sides are equipped with otic placode；
Bone screw holes include being arranged on the end bone screw holes at plate body both ends and the side seam nail hole being arranged on otic placode.
3. magnesium alloy bone plate according to claim 2, which is characterized in that in the length direction of plate body, side seam nail hole exists
The both sides of plate body are arranged alternately successively.
4. magnesium alloy bone plate according to claim 3, which is characterized in that formed in plate body front and back multiple recessed
Cheat array.
5. magnesium alloy bone plate according to claim 4, which is characterized in that auxiliary hole is provided between adjacent pit array, is used for
Adjust the shearing resistance section factor of plate body in the longitudinal direction.
6. magnesium alloy bone plate according to claim 5, which is characterized in that the auxiliary hole between adjacent pit array is a pair,
Corresponding two auxiliary hole separations are in the both sides of plate body length direction midship section.
7. according to any magnesium alloy bone plate of claim 4 ~ 6, which is characterized in that pit array is line-column matrix；
Pit depth is not more than 1/7th of plate body plate thickness, and not less than 1/10th of plate body plate thickness；
Pit bore is 1.5 ~ 2.5 times of pit depth.
A kind of 8. production method of magnesium alloy bone plate as described in claim 1 ~ 7 is any, which is characterized in that the production method
Include the following steps：
1）Pretreatment：Surface polishing, cleaning are carried out, and then dry to the matrix of given magnesium or magnesium alloy material, then to base
Body carries out surface roughening treatment；
2）Spraying：Using cold spraying method, granularity is sprayed into matrix surface for 80-150 μm of povidone iodine and forms coating.
9. production method according to claim 8, which is characterized in that the surface roughening treatment to matrix is using 50 mesh stones
The sandblasting roughening treatment of sand.
10. production method according to claim 8, which is characterized in that using inert gas as working gas during spraying,
And obtain the coating of different-thickness by adjusting air pressure and powder feeding pressure and the mode of spray distance.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810011284.2A CN108186097B (en) | 2018-01-05 | 2018-01-05 | Magnesium alloy bone fracture plate and manufacturing method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810011284.2A CN108186097B (en) | 2018-01-05 | 2018-01-05 | Magnesium alloy bone fracture plate and manufacturing method thereof |
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| CN109171935A (en) * | 2018-10-15 | 2019-01-11 | 济南大学 | Magnesium alloy fracture of tibia bone plate |
| CN109316233A (en) * | 2018-11-07 | 2019-02-12 | 济南大学 | Tibia bone plate |
| CN109330674A (en) * | 2018-09-07 | 2019-02-15 | 西安卓恰医疗器械有限公司 | A kind of internal fixation system and its usage mode |
| CN111150476A (en) * | 2019-03-13 | 2020-05-15 | 郭占林 | Degradable rib bone fracture plate |
| CN113456898A (en) * | 2021-07-08 | 2021-10-01 | 济南大学 | Preparation method of medical titanium alloy surface-loaded iodine |
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