CN108175863A - A kind of composition positioned for Lung neoplasm before Video-assisted mini-thoracectomy, preparation and preparation method thereof - Google Patents
A kind of composition positioned for Lung neoplasm before Video-assisted mini-thoracectomy, preparation and preparation method thereof Download PDFInfo
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- CN108175863A CN108175863A CN201711459252.0A CN201711459252A CN108175863A CN 108175863 A CN108175863 A CN 108175863A CN 201711459252 A CN201711459252 A CN 201711459252A CN 108175863 A CN108175863 A CN 108175863A
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Abstract
The present invention provides a kind of composition positioned for Lung neoplasm before Video-assisted mini-thoracectomy, preparation and preparation method thereof, and the composition includes following raw material：Methylene blue, contrast medium and medical glue, volume ratio 1:(0.8~1.2)：(2~4).Its formulation preparation method includes the following steps：Medical glue is placed in water-bath, is heated up with 0.2~0.4 DEG C/min rates, is slowly added to contrast medium, is warming up to 50~60 DEG C of holding 20~40min of heating water bath, obtains just mixed liquid；First mixed liquid is placed in mixing machine, 15~25Hz mixes 5~15min, obtains premixed liquid；Premixed liquid is added in homogenizer, methylene blue is added in, carries out second homogenate, 40~50 DEG C of first time homogenizing temperature, 10~20Mpa of homogenization pressure, 5~10min of homogenizing time, second 50~60 DEG C of homogenizing temperature, 3~8Mpa of homogenization pressure, 10~20min of homogenizing time, obtain capsule core material；Capsule core material is embedded into starch coating, targeting agent is made in compacting.Using bit combination object of the present invention, small pulmonary artery can be quickly and accurately found out, safely, effectively, economical, flexibly, can be widely applied to clinic.
Description
Technical field
The present invention relates to medical agent field, more particularly to a kind of composition positioned for Lung neoplasm before Video-assisted mini-thoracectomy,
Preparation and preparation method thereof.
Background technology
Small pulmonary artery (smallpulmonarynodules, SPN) is that pulmonary parenchyma interior diameter is less than 2cm, round or oval
Shape, usually without atelectasis and the increase in density shadow of enlargement of lymph nodes；Diameter≤1cm person is also known as sub- centimetre tubercle；It is focal
Property cloud increase in density shadow, blood vessel and the distinguishable person of bronchus clean mark are known as ground glass sample lesion (ground in tubercle
Glass opacity, GGO).With the raising of people's health consciousness and the extensive use of chest CT, small pulmonary artery especially GGO
Recall rate dramatically increase.It is reported that 60% is up to more than the pernicious rates of the SPN of 1cm, and the pernicious rates of GGO are up to 73%.Intrapulmonary is small
Tubercle even if only several millimeters of sizes, also there is the possibility of malignant change, and the SPN found in clinical position will be examined clearly as early as possible
It is disconnected.It is difficult to judge that small pulmonary artery is good pernicious according to patient clinical symptom and Features, the false negative rate of aspiration biopsy is very high,
For still considering the SPN row video assisted thoracic operations (video-assistedthoracoscopic of malignant change after clinical observation
Surgery, VATS) wedge excision is the current optimum way for obtaining small pulmonary artery pathological examination and same period radical cure.But due to lung
Lesser tubercle volume is too small, and GGO quality is softer, is difficult fast and accurately to find lesion during VATS, is visited in art so that increasing
Look into the time, in turn on chest rate, operation wound and average stay, deviated from the original idea of Minimally Invasive Surgery.It is found when in VATS arts
When difficult, preoperative positioning is carried out to Small pulmonary nodule to be particularly important.
Invention content
For mirror with this, the present invention proposes a kind of composition, preparation and its preparation side positioned for Lung neoplasm before Video-assisted mini-thoracectomy
Method solves above-mentioned technical problem.
The technical proposal of the invention is realized in this way：A kind of composition positioned for Lung neoplasm before Video-assisted mini-thoracectomy, packet
Include following raw material：Methylene blue, contrast medium and medical glue, the volume ratio of the methylene blue, contrast medium and medical glue is 1:(0.8~
1.2)：(2~4).
Further, the composition includes the raw material of volumes below：Methylene blue 0.5ml, contrast medium 0.4ml~0.6ml and
Medical 1~2ml of glue.
Further, the composition includes the raw material of volumes below：Methylene blue 0.5ml, contrast medium 0.5ml and medical glue
1~2ml.
Further, the contrast medium is iodine contrast medium.
The present invention also provides a kind of targeting agent positioned for Lung neoplasm before Video-assisted mini-thoracectomy, comprising described in any one of the present invention
The composition positioned for Lung neoplasm before Video-assisted mini-thoracectomy.
Further, the dosage form of the targeting agent is capsule, and the film of the capsule is can dissolve coating.
Further, the film of the capsule is coated for starch.
The present invention also provides a kind of preparation method of the targeting agent positioned for Lung neoplasm before Video-assisted mini-thoracectomy, including following step
Suddenly：
S1, pre-treatment:Medical glue is placed in water-bath, is heated up with 0.2~0.4 DEG C/min rates, by weight
Ratio is slowly added to contrast medium, is warming up to 50~60 DEG C of holding 20~40min of heating water bath, obtains just mixed liquid；
S2, premix：The first mixed liquid of step S1 is placed in mixing machine, is mixed, mixed frequency is 15~25Hz, is mixed
Time is 5~15min, obtains premixed liquid；
S3, it always mixes：The premixed liquid of step S2 is added in homogenizer, adds in methylene blue by weight proportion, carries out second homogenate,
40~50 DEG C of first time homogenizing temperature, 10~20Mpa of homogenization pressure, 5~10min of homogenizing time, second of homogenizing temperature 50~
60 DEG C, 3~8Mpa of homogenization pressure, 10~20min of homogenizing time, obtain capsule core material；
S4, preparation：Capsule core material made from step S3 is embedded into starch coating, compacting, targeting agent, every positioning is made
Agent 0.4ml containing methylene blue~0.6ml, contrast medium 0.4ml~0.6ml and medical 1~2ml of glue.
Further, in the S2 steps, mixed frequency 20Hz, incorporation time 10min.
Further, in the S3 steps, first time homogenization pressure 15Mpa, homogenizing time 8min, second of homogenization pressure
5Mpa, homogenizing time 15min.
Compared with prior art, the beneficial effects of the invention are as follows：The composition of the present invention is combined using methylene blue, medical glue
Contrast medium, scientific matching make its good positioning effect, and conducive to assurance of the operation consent doctor to lesion situation, clinical application effect is good.
The composition of the lower injection present invention of CT guiding in the preoperative, is directly dissolved in lung and pleural surface, methylene blue, contrast medium and medical glue
Three kinds are closed liquid and are frozen into strip immediately and form reference substance in art, high-visible under image, specific location are assessed, with the three of lung neoplasm
Dimension relationship conducive to operation, can quickly and accurately find out small pulmonary artery, greatly shorten preoperative positioning time, improve the standard of positioning
True rate conducive to the assurance to lesion situation, accurately grasps pathological examination, and the lung tissue of more preferable accurate excision lesion reduces preoperative
Complication rate is positioned, reduces preoperative positioning expense, probe time in desmopyknosis shortens operating time, chest is turned in reduction
Rate shortens average stay.Composition and its preparation using the present invention, making is simple, expense is few, convenient and practical, safety,
Effectively, flexibly, it can be widely applied to clinic.Moreover, the composition of the present invention to be made to the targeting agent of capsule-type, when use, is put into
Puncture needle, needle injection, greatly shortens injection time, improves clinical application effect and location efficiency.Further, originally
Invention combines always mixed preparation method using pre-treatment, premix, and soft capsule targeting agent obtained has better applied to clinic
Effect.
Description of the drawings
Fig. 1~3 are schemed using the CT before and after 1 composition of embodiment, wherein,
Fig. 1 is middle lobe of right lung pleura inferior thyroid tubercle stove lung window；
Fig. 2 injects puncture needle for 1 composition of middle lobe of right lung pleura inferior thyroid tubercle stove embodiment and positions lung window, intends in needle tip
The injectable composition at tubercle stove about 0.5cm；
Fig. 3 is 1 composition mediastinum window of middle lobe of right lung pleura inferior thyroid tubercle stove embodiment, is being noted at tubercle stove about 0.5cm
Composition is penetrated, can clearly show the three-dimensional situations such as lesion and the distance of composition；
Fig. 4~6 are schemed using the CT before and after 2 composition of embodiment, wherein,
Fig. 4 is superior lobe of right lung leading portion tubercle stove lung window；
Fig. 5 for 2 composition of superior lobe of right lung leading portion tubercle stove embodiment inject puncture needle position lung window, intend needle tip away from
From injectable composition at tubercle stove about 0.8cm；
Fig. 6 is 2 composition lung window of superior lobe of right lung leading portion tubercle stove embodiment, in the injection group at tubercle stove about 0.8cm
Object is closed, can clearly show the three-dimensional situations such as lesion and the distance of composition；
Fig. 7~10 are schemed using the CT before and after 3 composition of embodiment, wherein,
Fig. 7 is upper lobe of left lung tubercle stove lung window；
Fig. 8 is upper lobe of left lung tubercle stove mediastinum window；
Fig. 9 is 3 composition lung window of upper lobe of left lung tubercle stove embodiment, can in the injectable composition at tubercle stove about 1cm
The three-dimensional situations such as clear display lesion and the distance of composition；
Figure 10 is 3 composition mediastinum window of upper lobe of left lung tubercle stove embodiment, and combination is being injected at tubercle stove about 1cm
Object can clearly show the three-dimensional situations such as lesion and the distance of composition；
Figure 11~15 are schemed using the CT before and after 1 composition of comparative example, wherein,
Figure 11 is middle lobe of right lung tubercle stove lung window；
Figure 12 is middle lobe of right lung tubercle stove mediastinum window；
Figure 13 injects puncture needle for 1 composition of middle lobe of right lung tubercle stove comparative example and positions lung window, intends in needle tip distance
Injectable composition at tubercle stove about 0.5cm；
Figure 14 is lung window after the injection of 1 composition of upper lobe of left lung tubercle stove comparative example, is being injected at tubercle stove about 0.5cm
Composition only shows that tubercle, in tentiform protrusion, fails composition situation after display injection, can not be that clinical operation is cured adjacent to pleura
Teacher provides accurately preoperative reference, is unfavorable for assurance of the operation consent doctor to lesion situation；
Figure 15 injects posterior mediastinum window for 1 composition of upper lobe of left lung tubercle stove comparative example, is being noted at tubercle stove about 0.5cm
Composition is penetrated, only shows that tubercle, in tentiform protrusion, fails composition situation after display injection, can not be clinical operation adjacent to pleura
Doctor provides accurately preoperative reference, does not utilize assurance of the operation consent doctor to lesion situation.
Specific embodiment
In order to be best understood from the technology of the present invention content, specific embodiment is provided below, and with reference to attached drawing the present invention is done into
The explanation of one step.
Embodiment 1
A kind of composition positioned for Lung neoplasm before Video-assisted mini-thoracectomy, including following raw material：Methylene blue, contrast medium and medical adhesive
Water, the volume ratio of the methylene blue, contrast medium and medical glue is 1:0.8：2.
A kind of preparation method of the targeting agent positioned for Lung neoplasm before Video-assisted mini-thoracectomy, includes the following steps：
S1, pre-treatment:Medical glue is placed in water-bath, is heated up with 0.3 DEG C/min rates, by above-mentioned composition
Weight ratio is slowly added to contrast medium, is warming up to 55 DEG C of holding heating water bath 30min, obtains just mixed liquid；
S2, premix：The first mixed liquid of step S1 is placed in mixing machine, is mixed, mixed frequency 20Hz, incorporation time
For 10min, premixed liquid is obtained；
S3, it always mixes：The premixed liquid of step S2 is added in homogenizer, methylene blue is added in by above-mentioned composition weight ratio, into
Row second homogenate, 45 DEG C of first time homogenizing temperature, homogenization pressure 15Mpa, homogenizing time 8min, second of 55 DEG C of homogenizing temperature,
Homogenization pressure 5Mpa, homogenizing time 15min, obtain capsule core material；
S4, preparation：Capsule core material made from step S3 is embedded into starch coating, strip soft capsule is made, i.e., in compacting
Obtain targeting agent, every targeting agent 0.5ml containing methylene blue, contrast medium 0.4ml and medical glue 1ml.
Using the CT figures before and after the present embodiment composition as shown in Figures 1 to 3,
Fig. 1 is middle lobe of right lung pleura inferior thyroid tubercle stove lung window；
Fig. 2 injects puncture needle for 1 composition of middle lobe of right lung pleura inferior thyroid tubercle stove embodiment and positions lung window, intends in needle tip
The injectable composition at tubercle stove about 0.5cm；
Fig. 3 is 1 composition mediastinum window of middle lobe of right lung pleura inferior thyroid tubercle stove embodiment, is being noted at tubercle stove about 0.5cm
Composition is penetrated, can clearly show the three-dimensional situations such as lesion and the distance of composition.
Embodiment 2
A kind of composition positioned for Lung neoplasm before Video-assisted mini-thoracectomy, including following raw material：Methylene blue, contrast medium and medical adhesive
Water, the volume ratio of the methylene blue, contrast medium and medical glue is 1:1.2：4.
A kind of preparation method of the targeting agent positioned for Lung neoplasm before Video-assisted mini-thoracectomy, includes the following steps：
S1, pre-treatment:Medical glue is placed in water-bath, is heated up with 0.3 DEG C/min rates, by above-mentioned composition
Weight ratio is slowly added to contrast medium, is warming up to 55 DEG C of holding heating water bath 30min, obtains just mixed liquid；
S2, premix：The first mixed liquid of step S1 is placed in mixing machine, is mixed, mixed frequency 20Hz, incorporation time
For 10min, premixed liquid is obtained；
S3, it always mixes：The premixed liquid of step S2 is added in homogenizer, methylene blue is added in by above-mentioned composition weight ratio, into
Row second homogenate, 45 DEG C of first time homogenizing temperature, homogenization pressure 15Mpa, homogenizing time 8min, second of 55 DEG C of homogenizing temperature,
Homogenization pressure 5Mpa, homogenizing time 15min, obtain capsule core material；
S4, preparation：Capsule core material made from step S3 is embedded into starch coating, strip soft capsule is made, i.e., in compacting
Obtain targeting agent, every targeting agent 0.5ml containing methylene blue, contrast medium 0.6ml and medical glue 2ml.
Using the CT figures before and after the present embodiment composition as shown in figures 4-6,
Fig. 4 is superior lobe of right lung leading portion tubercle stove lung window；
Fig. 5 for 2 composition of superior lobe of right lung leading portion tubercle stove embodiment inject puncture needle position lung window, intend needle tip away from
From injectable composition at tubercle stove about 0.8cm；
Fig. 6 is 2 composition lung window of superior lobe of right lung leading portion tubercle stove embodiment, in the injection group at tubercle stove about 0.8cm
Object is closed, can clearly show the three-dimensional situations such as lesion and the distance of composition.
Embodiment 3
A kind of composition positioned for Lung neoplasm before Video-assisted mini-thoracectomy, including following raw material：Methylene blue, contrast medium and medical adhesive
Water, the volume ratio of the methylene blue, contrast medium and medical glue is 1:1：3.
A kind of preparation method of the targeting agent positioned for Lung neoplasm before Video-assisted mini-thoracectomy, includes the following steps：
S1, pre-treatment:Medical glue is placed in water-bath, is heated up with 0.3 DEG C/min rates, by above-mentioned composition
Weight ratio is slowly added to contrast medium, is warming up to 55 DEG C of holding heating water bath 30min, obtains just mixed liquid；
S2, premix：The first mixed liquid of step S1 is placed in mixing machine, is mixed, mixed frequency 20Hz, incorporation time
For 10min, premixed liquid is obtained；
S3, it always mixes：The premixed liquid of step S2 is added in homogenizer, methylene blue is added in by above-mentioned composition weight ratio, into
Row second homogenate, 45 DEG C of first time homogenizing temperature, homogenization pressure 15Mpa, homogenizing time 8min, second of 55 DEG C of homogenizing temperature,
Homogenization pressure 5Mpa, homogenizing time 15min, obtain capsule core material；
S4, preparation：Capsule core material made from step S3 is embedded into starch coating, strip soft capsule is made, i.e., in compacting
Obtain targeting agent, every targeting agent 0.5ml containing methylene blue, contrast medium 0.5ml and medical glue 1.5ml.
Schemed as shown in Fig. 7~10 using the CT before and after the present embodiment composition,
Fig. 7 is upper lobe of left lung tubercle stove lung window；
Fig. 8 is upper lobe of left lung tubercle stove mediastinum window；
Fig. 9 is 3 composition lung window of upper lobe of left lung tubercle stove embodiment, can in the injectable composition at tubercle stove about 1cm
The three-dimensional situations such as clear display lesion and the distance of composition；
Figure 10 is 3 composition mediastinum window of upper lobe of left lung tubercle stove embodiment, and combination is being injected at tubercle stove about 1cm
Object can clearly show the three-dimensional situations such as lesion and the distance of composition.
Embodiment 4
A kind of composition positioned for Lung neoplasm before Video-assisted mini-thoracectomy, including following raw material：Methylene blue, contrast medium and medical adhesive
Water, the volume ratio of the methylene blue, contrast medium and medical glue is 1:1：3.
A kind of preparation method of the targeting agent positioned for Lung neoplasm before Video-assisted mini-thoracectomy, includes the following steps：
S1, pre-treatment:Medical glue is placed in water-bath, is heated up with 0.2 DEG C/min rates, by above-mentioned composition
Weight ratio is slowly added to contrast medium, is warming up to 50 DEG C of holding heating water bath 40min, obtains just mixed liquid；
S2, premix：The first mixed liquid of step S1 is placed in mixing machine, is mixed, mixed frequency 15Hz, incorporation time
For 15min, premixed liquid is obtained；
S3, it always mixes：The premixed liquid of step S2 is added in homogenizer, methylene blue is added in by above-mentioned composition weight ratio, into
Row second homogenate, 40 DEG C of first time homogenizing temperature, homogenization pressure 10Mpa, homogenizing time 10min, second of 50 DEG C of homogenizing temperature,
Homogenization pressure 3Mpa, homogenizing time 20min, obtain capsule core material；
S4, preparation：Capsule core material made from step S3 is embedded into starch coating, strip soft capsule is made, i.e., in compacting
Obtain targeting agent, every targeting agent 0.5ml containing methylene blue, contrast medium 0.5ml and medical glue 1.5ml.
Embodiment 5
A kind of composition positioned for Lung neoplasm before Video-assisted mini-thoracectomy, including following raw material：Methylene blue, contrast medium and medical adhesive
Water, the volume ratio of the methylene blue, contrast medium and medical glue is 1:1：3.
A kind of preparation method of the targeting agent positioned for Lung neoplasm before Video-assisted mini-thoracectomy, includes the following steps：
S1, pre-treatment:Medical glue is placed in water-bath, is heated up with 0.4 DEG C/min rates, by above-mentioned composition
Weight ratio is slowly added to contrast medium, is warming up to 60 DEG C of holding heating water bath 20min, obtains just mixed liquid；
S2, premix：The first mixed liquid of step S1 is placed in mixing machine, is mixed, mixed frequency 25Hz, incorporation time
For 5min, premixed liquid is obtained；
S3, it always mixes：The premixed liquid of step S2 is added in homogenizer, methylene blue is added in by above-mentioned composition weight ratio, into
Row second homogenate, 50 DEG C of first time homogenizing temperature, homogenization pressure 20Mpa, homogenizing time 5min, second of 60 DEG C of homogenizing temperature,
Homogenization pressure 8Mpa, homogenizing time 10min, obtain capsule core material；
S4, preparation：Capsule core material made from step S3 is embedded into starch coating, strip soft capsule is made, i.e., in compacting
Obtain targeting agent, every targeting agent 0.5ml containing methylene blue, contrast medium 0.5ml and medical glue 1.5ml.
Embodiment 6
A kind of composition positioned for Lung neoplasm before Video-assisted mini-thoracectomy, including following raw material：Methylene blue, contrast medium and medical adhesive
Water, the volume ratio of the methylene blue, contrast medium and medical glue is 1:1：3.
A kind of preparation method of the targeting agent positioned for Lung neoplasm before Video-assisted mini-thoracectomy, includes the following steps：
S1, mixing:Medical glue, contrast medium, methylene blue in above-mentioned composition ratio are mixed, obtain capsule core material；
S2, preparation：Capsule core material made from step S3 is embedded into starch coating, strip soft capsule is made, i.e., in compacting
Obtain targeting agent, every targeting agent 0.5ml containing methylene blue, contrast medium 0.5ml and medical glue 1.5ml.
Comparative example 1
A kind of composition positioned for Lung neoplasm before Video-assisted mini-thoracectomy, including following raw material：Methylene blue and medical glue, it is described
The volume ratio of methylene blue and medical glue is 1:3.
A kind of preparation method of the targeting agent positioned for Lung neoplasm before Video-assisted mini-thoracectomy, includes the following steps：
S1, pre-treatment:Medical glue is placed in water-bath, is heated up with 0.3 DEG C/min rates, is warming up to 55 DEG C of guarantors
Hold heating water bath 30min；
S2, mixing：Premixed liquid is added in homogenizer, methylene blue is added in by above-mentioned composition weight ratio, is carried out secondary equal
Matter, 45 DEG C of first time homogenizing temperature, homogenization pressure 15Mpa, homogenizing time 8min, second 55 DEG C of homogenizing temperature, homogenization pressure
5Mpa, homogenizing time 15min, obtain capsule core material；
S3, preparation：Capsule core material made from step S3 is embedded into starch coating, strip soft capsule is made, i.e., in compacting
Obtain targeting agent, every targeting agent 0.5ml containing methylene blue and medical glue 1.5ml.
Schemed as shown in Figure 11~15 using the CT before and after this comparative example composition,
Figure 11 is middle lobe of right lung tubercle stove lung window；
Figure 12 is middle lobe of right lung tubercle stove mediastinum window；
Figure 13 injects puncture needle for 1 composition of middle lobe of right lung tubercle stove comparative example and positions lung window, intends in needle tip distance
Injectable composition at tubercle stove about 0.5cm；
Figure 14 is lung window after the injection of 1 composition of upper lobe of left lung tubercle stove comparative example, is being injected at tubercle stove about 0.5cm
Composition only shows that tubercle, in tentiform protrusion, fails composition situation after display injection, can not judge composition adjacent to pleura
Specific location also can not judge whether composition drains to thoracic cavity, accurate preoperative reference can not be provided for clinical operation doctor, no
Conducive to assurance of the operation consent doctor to lesion situation；
Figure 15 injects posterior mediastinum window for 1 composition of upper lobe of left lung tubercle stove comparative example, is being noted at tubercle stove about 0.5cm
Composition is penetrated, only shows that tubercle, in tentiform protrusion, fails composition situation after display injection, can not judge composition adjacent to pleura
Specific location, also can not judge whether composition drains to thoracic cavity, accurate preoperative reference can not be provided for clinical operation doctor,
Assurance of the operation consent doctor to lesion situation is not utilized.
Comparative example 2
A kind of composition positioned for Lung neoplasm before Video-assisted mini-thoracectomy, including following raw material：Methylene blue, contrast medium and medical adhesive
Water, the volume ratio of the methylene blue, contrast medium and medical glue is 1:2：1.Preparation method is same as Example 3.
Above-described embodiment 1~6 and 1~2 obtained targeting agent of comparative example are applied to clinic：
Collect 180 SPN patients, age 33-75 Sui, average (52.34 ± 10.49) year, lesion diameter 5-15mm is averaged
(9.53±2.43)mm.SPN patient's inclusion criteria：1. all selected cases meet the diagnostic criteria of small pulmonary artery；②5mm≤
Diameter≤15mm and 10mm≤apart from visceral pleura distance≤30mm；3. patient agrees to video assisted thoracic operation and with reference to iconography
Feature considers to find difficulty person in art；4. case-data is complete；5. Solitary nodules.Exclusion criteria：1. diameter>15mm or<5mm；
2. apart from visceral pleura distance>30mm or<10mm；3. Pulmonary Vascular venereal disease becomes or close to Pulmonary vascular disease；4. serious cardio-pulmonary function
It is incomplete or have hemorrhagic tendency patient；5. respiratory tract acute infection, fever, the uncontrolled person of cough；6. the imperfect person of case-data；
7. two and more than two tubercles.It is randomly divided into 9 test groups, every group 20, wherein, test group 1~8 is in the preoperative under CT guiding
The targeting agent of corresponding injection Examples 1 to 6 and comparative example 1~2 respectively, is put into puncture needle by strip capsule targeting agent, makes
Used time, one needle was injected under intrapulmonary and pleura, was injected at around 0.5~1cm of lesion, was directly dissolved in lung and pleural surface；
Test group 9 uses traditional preoperative positioning mode of spring ring, and spring ring end should be placed under pleura.
The effect of 1~2 obtained targeting agent clinical practice of above-described embodiment 1~6 and comparative example is as follows：
The above results show the composition of the lower injection embodiment of the present invention 1~6 of CT guiding in the preoperative, can quickly, accurately
Find small pulmonary artery, greatly shorten preoperative positioning time, improve the accuracy rate of positioning, it is accurate conducive to the assurance to lesion situation
Pathological examination is really grasped, the lung tissue of more preferable accurate excision lesion reduces preoperative positioning complication rate, reduces preoperative positioning
Expense, probe time in desmopyknosis shorten operating time, and chest rate is turned in reduction, shorten average stay.Using the present invention
Composition and its preparation, make that simple, expense is few, convenient and practical, safely, effectively, flexibly, can be widely applied to clinic.It will
The composition of the present invention makes the targeting agent of capsule-type, and when use is put into puncture needle, needle injection, when greatly shortening injection
Between, improve location efficiency.Wherein, the preoperative positioning mode of traditional spring ring is compared, clinical application effect is relatively poor, expense
It is high；Comparative example 1~2 is compared with embodiment 3, shows the present invention using methylene blue, medical glue combination contrast medium, scientific matching makes
Its clinical application effect is good, good positioning effect, more conducively assurance of the operation consent doctor to lesion situation.In addition, Examples 1 to 2
It is compared with embodiment 3, the clinical application effect of embodiment 3 is best, has more preferably locating effect, more conducively operation consent doctor couple
The assurance of lesion situation, the composition proportioning for showing embodiment 3 is best；Embodiment 6 is compared with embodiment 3~5, embodiment
3~5 clinical application effect is relatively preferable, shows that the present invention combines always mixed preparation method using pre-treatment, premix, obtained
Soft capsule targeting agent has better effect applied to clinic；Embodiment 4~5 is compared with embodiment 3, and the clinic of embodiment 3 should
With best results, show that the preparation method technological parameter of embodiment 3 is best.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention
With within principle, any modification, equivalent replacement, improvement and so on should all be included in the protection scope of the present invention god.
Claims (10)
1. a kind of composition positioned for Lung neoplasm before Video-assisted mini-thoracectomy, which is characterized in that including following raw material：Methylene blue, comparison
Agent and medical glue, the volume ratio of the methylene blue, contrast medium and medical glue is 1:(0.8~1.2)：(2~4).
2. a kind of composition positioned for Lung neoplasm before Video-assisted mini-thoracectomy as described in claim 1, which is characterized in that including with
The raw material of lower volume：Methylene blue 0.5ml, contrast medium 0.4ml~0.6ml and medical 1~2ml of glue.
3. a kind of composition positioned for Lung neoplasm before Video-assisted mini-thoracectomy as claimed in claim 2, which is characterized in that including with
The raw material of lower volume：Methylene blue 0.5ml, contrast medium 0.5ml and medical 1~2ml of glue.
4. a kind of composition positioned for Lung neoplasm before Video-assisted mini-thoracectomy as described in claim 1, which is characterized in that described right
It is iodine contrast medium than agent.
5. a kind of targeting agent positioned for Lung neoplasm before Video-assisted mini-thoracectomy as described in claim 1, which is characterized in that include power
Profit requires composition of 1~4 any one of them for Lung neoplasm positioning before Video-assisted mini-thoracectomy.
6. a kind of targeting agent positioned for Lung neoplasm before Video-assisted mini-thoracectomy as claimed in claim 5, which is characterized in that described fixed
The dosage form of position agent is capsule, and the film of the capsule is can dissolve coating.
A kind of 7. targeting agent positioned for Lung neoplasm before Video-assisted mini-thoracectomy as claimed in claim 6, which is characterized in that the glue
The film of wafer is coated for starch.
8. a kind of preparation method of targeting agent positioned for Lung neoplasm before Video-assisted mini-thoracectomy as claimed in claim 5, feature
It is, includes the following steps：
S1, pre-treatment:Medical glue is placed in water-bath, is heated up with 0.2~0.4 DEG C/min rates, by weight proportion
Contrast medium is slowly added to, is warming up to 50~60 DEG C of holding 20~40min of heating water bath, obtains just mixed liquid；
S2, premix：The first mixed liquid of step S1 is placed in mixing machine, is mixed, mixed frequency be 15~25Hz, incorporation time
For 5~15min, premixed liquid is obtained；
S3, it always mixes：The premixed liquid of step S2 is added in homogenizer, adds in methylene blue by weight proportion, carries out second homogenate, first
Secondary 40~50 DEG C of homogenizing temperature, 10~20Mpa of homogenization pressure, 5~10min of homogenizing time, second of 50~60 DEG C of homogenizing temperature,
3~8Mpa of homogenization pressure, 10~20min of homogenizing time, obtain capsule core material；
S4, preparation：Capsule core material made from step S3 is embedded into starch coating, targeting agent is made in compacting, and every targeting agent contains
Methylene blue 0.4ml~0.6ml, contrast medium 0.4ml~0.6ml and medical 1~2ml of glue.
9. a kind of preparation method of targeting agent positioned for Lung neoplasm before Video-assisted mini-thoracectomy as claimed in claim 8, feature
It is, in the S2 steps, mixed frequency 20Hz, incorporation time 10min.
10. a kind of preparation method of targeting agent positioned for Lung neoplasm before Video-assisted mini-thoracectomy as claimed in claim 8, feature
It is, in the S3 steps, first time homogenization pressure 15Mpa, homogenizing time 8min, when second homogenization pressure 5Mpa, homogeneous
Between 15min.
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