CN108159431A - A kind of phosphatide complexes and preparation method thereof - Google Patents
A kind of phosphatide complexes and preparation method thereof Download PDFInfo
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- CN108159431A CN108159431A CN201711467009.3A CN201711467009A CN108159431A CN 108159431 A CN108159431 A CN 108159431A CN 201711467009 A CN201711467009 A CN 201711467009A CN 108159431 A CN108159431 A CN 108159431A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
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Abstract
The present invention relates to food technology fields, more particularly to molecule complex technique, it specifically refers to different types of phosphatide, it is mixed with small-molecular peptides, polysaccharide, anthocyanidin solution, to be rich in the linseed oil of 3 aliphatic acid of omega as carrier, it is compound that molecule is carried out using superhigh pressure technique, a kind of phosphatide complexes are made, so as to improve the biological absorption of polysaccharide, aliphatic acid, anthocyanidin etc., promote body Green Tea Extract oxidation resistance.Function phosphatide, polysaccharide, small-molecular peptides and anthocyanidin in the compound, unrighted acid etc. forms complex compound, it can be helped to be efficiently entering human body cell, prevent ingredient breakdown or inactivation, there is activating cell, balancing human body cell component, improve immune, Green Tea Extract anti-aging.
Description
Technical field
The present invention relates to biotechnology, more particularly to a kind of phosphatide complexes and preparation method thereof.
Background technology
One of important morphological feature that primitive life is obtained to Cellular evolution is that a tunic occur outside living matter
Property structure, i.e. " cell membrane ".Cell membrane is located at cell surface, and thickness is usually 7~8nm, and human cell membrane is by 40% or so
Protein and 50% or so lipid and 2%~10% carbohydrate are formed, wherein, the main component of lipid is phosphatide.Cell membrane
Most important characteristic is semi permeability or selective penetrated property, there is very strong selective penetrated property to the substance for entering and exiting cell.Cell
Film and Endomembrane system are collectively referred to as biomembrane (biomembrane), have identical basic structural feature.
Phosphatide is important amphiphilic substance, they are the important components of biomembrane.Nitrogenous or phosphorus the hydrophilic head that one end is,
The other end is the hydrophobic side of long hydrocarbyl chain.Due to this, phospholipid molecule water-wet side is close to each other, and hydrophobic side is close to each other, often
The structure of lipid bilayer, i.e. cell membrane is collectively formed with other molecules such as protein, glycolipid, cholesterol.
Carbohydrate, protein, fat are three big basal nutrient substances of human body, assimilate situation and are ceased with organism metabolism breath
It is related.In addition, for cell membrane fluidity, cell is maintained to adjust, growth and reparation are all essential.Using phosphatide with it is more
Intermolecular complexing improves the absorptivity of three major nutrient between sugar, peptide molecule, unrighted acid, adjusts cell
Nutritional ingredient, it is significant to the conditioning of health and metabolic disease.
Invention content
The object of the present invention is to provide a kind of phosphatide complexes and preparation method thereof.This method is will be different types of
Phosphatide oil, linseed oil are mixed with polysaccharide, small-molecular peptides, anthocyanidin solution, and a kind of multi-functional phosphorus is made using superhigh pressure technique
Fat complexes, phospholipid molecule, polysaccharide molecule, small-molecular peptides and anthocyanidin, unrighted acid etc. form complex compound in compound,
Enhance intermolecular force, absorbed so as to improve its bioavailability and human body cell.
For this purpose, technical scheme is as follows：
A kind of phosphatide complexes are the component of following parts by weight：- 8 parts of phosphatidase 2,1-2 parts of small-molecular peptides, polysaccharide 1-2
Part, 1-5 parts of linseed oil, 0.1-1.0 parts of anthocyanidin, 0.1-0.5 parts of ascorbic acid, 0.05-0.1 parts of vitamin A, vitamin E
0.03-0.08 parts, 0.01-0.05 parts of tea polyphenols, 0.1-0.5 parts of cycloheptaamylose.
Further, a kind of phosphatide complexes are the component of following parts by weight：- 7 parts of phosphatidase 3, small-molecular peptides 1.3-
1.7 parts, 1.3-1.7 parts of polysaccharide, 2-4 parts of linseed oil, 0.3-0.8 parts of anthocyanidin, 0.2-0.4 parts of ascorbic acid, vitamin A
0.07-0.09 parts, 0.05-0.07 parts of vitamin E, 0.02-0.04 parts of tea polyphenols, 0.2-0.4 parts of cycloheptaamylose.
Further, a kind of phosphatide complexes are the component of following parts by weight：Phosphatidase 5 part, 1.5 parts of small-molecular peptides,
1.5 parts of polysaccharide, 3 parts of linseed oil, 0.5 part of anthocyanidin, 0.3 part of ascorbic acid, 0.08 part of vitamin A, vitamin E 0.06
Part, 0.03 part of tea polyphenols, 0.3 part of cycloheptaamylose.
A kind of phosphatide complexes, the phosphatide are soybean lecithin, and yolk phospholipid is one or more in krill oil.
A kind of phosphatide complexes, the small-molecular peptides for molecular weight be less than 1000 dalton micromolecular collagen peptide or
Casein phosphopeptide.
A kind of phosphatide complexes, the polysaccharide refer in lactose, fructose, xylose, trehalose, chitosan, L-arabinose
It is one or more.
A kind of phosphatide complexes, preparation method are：
(1) phosphatide is uniformly mixed with small-molecular peptides, polysaccharide, linseed oil, anthocyanidin, 5-15 DEG C of homogeneous is made at vacuum
Reason, sealing, obtains mixture of phospholipids.
(2) vacuum packaging bag equipped with mixture of phospholipids is placed in 20-40 DEG C of extra-high tension unit made from taking in step (1)
Carry out ultra high pressure treatment, cooling.
(3) packaging bag crossed in step (2) through ultra high pressure treatment is sealed off, adds in ascorbic acid, vitamin A, vitamin
E, tea polyphenols, cycloheptaamylose are uniformly mixed to get phosphatide complexes.
Homogeneous described in step (1) is ultrasonic cell-break device Probe Ultrasonic Searching or homogenizer or colloid mill or microjet
Instrument.
Ultra high pressure treatment pressure described in step (2) is 400MPa-1000MPa.
The phosphatide complexes adjust aliphatic acid, peptide, carbohydrate, anthocyanidin, the absorption of curcumin and human body cell activation,
Application in Green Tea Extract anti-aging.
Beneficial effects of the present invention：
(1) it is compound using superhigh pressure technique progress phosphatide, change molecular polarity, strengthen intermolecular force and complexing work
With efficient quick is practical and convenient, and reaction is reversible；
(2) phosphatide is Life Base substance, has important meaning to human body cell and body health, phosphatide complex technique can
To improve the biological absorption of other nutriments, the exploitation for phosphatide Polyphenols drug or phosphatide flavonoids drug provides new think of
Road；
(3) phosphatide complexes of the present invention contain peptide, sugar, three big basal nutrient substance of protein, good absorption effect, to body
The dysbolisms such as glycometabolism, lipid metaboli, protein metabolism and the assist absorption for being metabolized patient are significant；
(4) super-pressure can realize sterilization while molecular complex, and the addition of ascorbic acid and vitamin E etc. is all prolonged
The shelf-life of phosphatide complexes of the present invention is grown.
Specific embodiment
The specific embodiment of form by the following examples makees further specifically the above of the present invention
It is bright.But the range that this should not be interpreted as to the above-mentioned theme of the present invention is only limitted to following embodiment.It is all to be based on the above of the present invention
The technology realized all belongs to the scope of the present invention.The implementation condition used in embodiment can be done further as the case may be
Adjustment, the implementation condition being not specified is usually the condition in routine experiment.
Embodiment 1
(1) by soybean lecithin 20kg and micromolecular collagen peptide 10kg, lactose 8kg, L-arabinose 2kg, linseed
Oily 10kg, anthocyanidin 1kg are uniformly mixed, and 5-15 DEG C of ultrasonic cell-break device Probe Ultrasonic Searching 15min makees vacuum processing, sealing,
Obtain mixture of phospholipids.
(2) vacuum packaging bag equipped with mixture of phospholipids is placed in 20-40 DEG C of extra-high tension unit made from taking in step (1)
Carry out 400MPa ultra high pressure treatments, cooling.
(3) packaging bag crossed in step (2) through ultra high pressure treatment is sealed off, add in ascorbic acid 1kg, vitamin A 500g,
Vitamin E 300g, tea polyphenols 100g, cycloheptaamylose 1kg are uniformly mixed to get phosphatide complexes.
Embodiment 2
(1) by soybean lecithin 30kg, yolk phospholipid 20kg, micromolecular collagen peptide 10kg, casein phosphopeptide 5kg,
Fructose 10kg, xylose 5kg, linseed oil 30kg, anthocyanidin 5kg are uniformly mixed, and 5-15 DEG C of homogenizer homogeneous 15min makees vacuum
Processing, sealing, obtains mixture of phospholipids.
(2) vacuum packaging bag equipped with mixture of phospholipids is placed in 20-40 DEG C of extra-high tension unit made from taking in step (1)
Carry out 600MPa ultra high pressure treatments, cooling.
(3) packaging bag crossed in step (2) through ultra high pressure treatment is sealed off, add in ascorbic acid 3kg, vitamin A 800g,
Vitamin E 600g, tea polyphenols 300g, cycloheptaamylose 3kg are uniformly mixed to get phosphatide complexes.
Embodiment 3
(1) by soybean lecithin 40kg, yolk phospholipid 30kg, micromolecular collagen peptide 12kg, casein phosphopeptide 5kg,
Trehalose 10kg, fructose 7kg, linseed oil 40kg, anthocyanidin 8kg are uniformly mixed, and 5-15 DEG C is crossed colloid mill 15min, makees vacuum
Processing, sealing, obtains mixture of phospholipids.
(2) vacuum packaging bag equipped with mixture of phospholipids is placed in 20-40 DEG C of extra-high tension unit made from taking in step (1)
Carry out 800MPa ultra high pressure treatments, cooling.
(3) packaging bag crossed in step (2) through ultra high pressure treatment is sealed off, add in ascorbic acid 4kg, vitamin A 900g,
Vitamin E 700g, tea polyphenols 400g, cycloheptaamylose 4kg are uniformly mixed to get phosphatide complexes.
Embodiment 4
(1) by soybean lecithin 50kg, krill oil 30kg, micromolecular collagen peptide 10kg, casein phosphopeptide 10kg, shell
Glycan 5kg, fructose 15kg, linseed oil 50kg, anthocyanidin 10kg are uniformly mixed, and 5-15 DEG C of microjet instrument handles 15min, later
Make vacuum processing, seal, obtain mixture of phospholipids.
(2) vacuum packaging bag equipped with mixture of phospholipids is placed in 20-40 DEG C of extra-high tension unit made from taking in step (1)
Carry out 1000MPa ultra high pressure treatments, cooling.
(3) packaging bag crossed in step (2) through ultra high pressure treatment is sealed off, add in ascorbic acid 5kg, retinol1 kg,
Vitamin E 800g, tea polyphenols 500g, cycloheptaamylose 5kg are uniformly mixed to get phosphatide complexes.
Claims (10)
1. a kind of phosphatide complexes, which is characterized in that be the component of following parts by weight：
- 8 parts of phosphatidase 1,1-2 parts of small-molecular peptides, 1-2 parts of polysaccharide, 1-5 parts of linseed oil, 0.1-1.0 parts of anthocyanidin, ascorbic acid
0.1-0.5 parts, 0.05-0.1 parts of vitamin A, 0.03-0.08 parts of vitamin E, 0.01-0.05 parts of tea polyphenols, cycloheptaamylose
0.1-0.5 parts.
2. a kind of phosphatide complexes according to claim 1, which is characterized in that be the component of following parts by weight：
- 7 parts of phosphatidase 2,1.3-1.7 parts of small-molecular peptides, 1.3-1.7 parts of polysaccharide, 2-4 parts of linseed oil, 0.3-0.8 parts of anthocyanidin,
0.2-0.4 parts of ascorbic acid, 0.07-0.09 parts of vitamin A, 0.05-0.07 parts of vitamin E, 0.02-0.04 parts of tea polyphenols,
0.2-0.4 parts of cycloheptaamylose.
3. a kind of phosphatide complexes according to claim 1, which is characterized in that be the component of following parts by weight：
Phosphatidase 5 part, 1.5 parts of small-molecular peptides, 1.5 parts of polysaccharide, 3 parts of linseed oil, 0.5 part of anthocyanidin, 0.3 part of ascorbic acid, dimension
Raw 0.08 part of element A, 0.06 part of vitamin E, 0.03 part of tea polyphenols, 0.3 part of cycloheptaamylose.
4. according to a kind of phosphatide complexes of claim 1-3 any one of them, which is characterized in that the phosphatide is soybean phosphorus
Fat, yolk phospholipid are one or more in krill oil.
5. according to a kind of phosphatide complexes of claim 1-3 any one of them, which is characterized in that the small-molecular peptides are molecule
Amount is less than the micromolecular collagen peptide or casein phosphopeptide of 1000 dalton.
6. according to a kind of phosphatide complexes of claim 1-3 any one of them, which is characterized in that the polysaccharide is lactose, fruit
It is one or more in sugar, xylose, trehalose, chitosan, L-arabinose.
A kind of a kind of 7. preparation method of phosphatide complexes of claim 1-3 any one of them, which is characterized in that the system
Preparation Method is：
(1) phosphatide is uniformly mixed with small-molecular peptides, polysaccharide, linseed oil, anthocyanidin, 5-15 DEG C of homogeneous makees vacuum processing, close
Envelope, obtains mixture of phospholipids；
(2) vacuum packaging bag equipped with mixture of phospholipids, which is placed in 20-40 DEG C of extra-high tension unit, made from taking in step (1) carries out
Ultra high pressure treatment, postcooling；
(3) packaging bag crossed in step (2) through ultra high pressure treatment is sealed off, adds in ascorbic acid, VitAVitE, tea
Polyphenol, cycloheptaamylose are uniformly mixed to get phosphatide complexes.
8. the preparation method of a kind of phosphatide complexes according to claim 7, which is characterized in that the homogeneous is ultrasonic wave
Cell Disruptor Probe Ultrasonic Searching or homogenizer or colloid mill or microjet instrument.
A kind of 9. preparation method of phosphatide complexes according to claim 7, which is characterized in that the ultra high pressure treatment pressure
Power is 400MPa-1000MPa.
10. claim 1-3 any one of them phosphatide complexes are adjusting aliphatic acid, peptide, carbohydrate, anthocyanidin, curcumin
It absorbs and the application in human body cell activation, Green Tea Extract anti-aging.
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| CN201711467009.3A CN108159431A (en) | 2017-12-28 | 2017-12-28 | A kind of phosphatide complexes and preparation method thereof |
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| CN201711467009.3A CN108159431A (en) | 2017-12-28 | 2017-12-28 | A kind of phosphatide complexes and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109430875A (en) * | 2018-11-26 | 2019-03-08 | 荣海生物科技有限公司 | A kind of linseed oil microcapsules and preparation method thereof containing small-molecular peptides |
| CN113842370A (en) * | 2021-11-01 | 2021-12-28 | 石家庄四药有限公司 | Arbidol hydrochloride tablet and preparation method thereof |
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|---|---|---|---|---|
| EP0162414A2 (en) * | 1984-05-15 | 1985-11-27 | Research Corporation | Amphipathic peptides and pharmaceutical compositions containing same |
| CN101537187A (en) * | 2008-03-18 | 2009-09-23 | 沈阳皓天万嘉医药科技有限公司 | Anthocyanin phospholipids compound and preparation method thereof |
| CN101715913A (en) * | 2008-12-02 | 2010-06-02 | 天津天狮生物发展有限公司 | Vivocon capsule and production process thereof |
| CN102688501A (en) * | 2012-06-20 | 2012-09-26 | 浙江萧山医院 | Proanthocyanidin B2 phospholipid compound, and preparation method and application thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109430875A (en) * | 2018-11-26 | 2019-03-08 | 荣海生物科技有限公司 | A kind of linseed oil microcapsules and preparation method thereof containing small-molecular peptides |
| CN113842370A (en) * | 2021-11-01 | 2021-12-28 | 石家庄四药有限公司 | Arbidol hydrochloride tablet and preparation method thereof |
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