CN108148144A - A kind of improvement of the preparation method of medicinal pregelatinized starch - Google Patents
A kind of improvement of the preparation method of medicinal pregelatinized starch Download PDFInfo
- Publication number
- CN108148144A CN108148144A CN201611095337.0A CN201611095337A CN108148144A CN 108148144 A CN108148144 A CN 108148144A CN 201611095337 A CN201611095337 A CN 201611095337A CN 108148144 A CN108148144 A CN 108148144A
- Authority
- CN
- China
- Prior art keywords
- pregelatinized starch
- preparation
- starch
- mixed
- medicinal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B30/00—Preparation of starch, degraded or non-chemically modified starch, amylose, or amylopectin
- C08B30/12—Degraded, destructured or non-chemically modified starch, e.g. mechanically, enzymatically or by irradiation; Bleaching of starch
- C08B30/14—Cold water dispersible or pregelatinised starch
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Inorganic Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Fodder In General (AREA)
- General Preparation And Processing Of Foods (AREA)
Abstract
The present invention is a kind of improvement of the preparation method of medicinal pregelatinized starch.The preparation method of the improved medicinal pregelatinized starch of the present invention includes：1st, material is weighed；2nd, the pretreatment of material；3rd, the mixing of material；The extrusion of 4 materials；5th, the drying of material；6th, the cutting and grinding of material.The preparation method is simple for process, easy to operate, and the structure for the pregelatinized starch produced is more uniformly distributed, water-soluble higher, the more preferable and splendid mobility of compressibility.And the preparation method is environmentally protective, and three wastes generate, and are conducive to environmental protection.
Description
Technical field
The invention belongs to starch physical modification fields, are related to a kind of modified starch, particularly improve a kind of medicinal pregelatinated
The preparation method of starch.
Background technology
Starch（starch）It is a kind of polysaccharide, is one of the natural polymer of nature yield maximum, is higher plant master
The carbohydrate component wanted, minor (C6H10O5) n, it can be by the amyloid substances such as corn, sweet potato, wild acorn nut and pueraria lobata
It extracts and obtains.Starch can be regarded as the high polymer of glucose.Starch is commercially used for paste producing essence, maltose, Portugal in addition to edible
Grape sugar, alcohol etc. are also used for modulation printing paste, the starching of textile, the gluing of paper, compacting of medicinal tablet etc..Therefore, it is
Preferably play the role of these, certain special natures of starch（Such as water solubility, stability, mobility, viscosity, gelatification
And shear strength etc.）It is indispensable.
Pregelatinized starch is the derivative of starch, also known as amylum pregelatinisatum, belongs to two class of pharmaceutic adjuvant.Pregelatinized starch
Preparation method be to be obtained some or all of rupture of starch granules with chemical method or Physical, only change its physical property
Without changing original chemical constitution.Therefore pregelatinized starch has good mobile performance and mouldability energy, and with good
Good lubricating action, can share the lubricant in direct powder compression with other auxiliary materials in drug production process, can also use
Make the adhesive of wet granulation, it may also be used for the auxiliary material of other solid materials such as capsule.
Pregelatinized starch on open market can be divided into full pregelatinized starch and part pregelatinated according to pregelatinated degree
Starch.Pregelatinated degree is different, then function is also different.The product of major part company is part pre-gel both at home and abroad, wherein
That more well-known is the product Starch1500 of the happy Kanggong department of card.France Roquette Freres then have all with part pregelatinated
Two kinds of products of starch.It has significant advantage in the world market share of pregelatinized starch.Full pregelatinized starch can be complete
Fully dissolved directly prepares starch slurry in water, for that can not be heated during wet granulation, therefore can together add with main ingredient, excipient
Enter in facility for granulating, then plus water is as wetting agent.Partially pregelatinized starch contains soluble（Gelation）With can not melt into
Point, because with disintegration properties are had concurrently in addition to stickiness, and with good mobility.
What production pregelatinized starch generally used at present is all wet method processing technology to prepare.However conventional machining process is given birth to
The pregelatinized starch poor quality of production, the scope of application are small.The pregelatinized starch prepared with method of chemical treatment, which easily generates, human body
Harmful substance, and production technology is complicated, unstable product quality is uniform.
Invention content
The primary and foremost purpose of the present invention is to overcome the difficulty and deficiency of the prior art, improves a kind of medicinal pregelatinized starch
Preparation method, the problem of can effectively solve the problem that stickiness, mobility, stability and the poorly water-soluble of existing pregelatinized starch,
The deficiencies of uniform existing production technology unstable product quality, poor fluidity, uncontrollable pregelatinated degree can effectively be overcome it
Place, and the application performance of medicinal pregelatinized starch can be effectively improved.
The present invention is handled starch, and at low temperature using grinding, ultrasonic vibration mixed method and extruding technology
It is molded after cooling is dry using cutting machine pelletizing.The quality for making pregelatinized starch by ultrasonic vibration mixed method is more uniform steady
Fixed, mobility improves, and compressibility can be more preferable, and the process conditions such as the rotating speed of the proportioning of control material and extruder, temperature are come
Control the pregelatinated degree of starch.
Ultrasonic vibration hybrid technology refers to material under the conditions of existing for certain frequency ultrasonic wave, using high-speed mixer machine
What group was mixed, enable material more uniform, stable in the process of mixing.
It is an object of the invention to for existing for insufficient and pregelatinized starch properties of product existing for existing production technology
Ultrasonic vibration mixed method is applied in starch conversion, improves a kind of method for preparing medicinal pregelatinized starch by defect.Packet
Include following steps：
A, material is weighed：Weigh a certain amount of food-grade starches and purified water；
B, the pretreatment of material：Load weighted material is placed in 40 ~ 60min of grinding in grinder；
C, the mixing of material：Ground material is placed in mixed at high speed unit, and mixed at high speed unit is made to be placed in ultrasonic wave ring
Under border, 30 ~ 50min is mixed, the moisture of material is 10% ~ 40% after control mixing；
D, the extrusion of material：The material mixed is added into extruder charging hopper, opens extruder, controls extruder temperature,
It is squeezed out at a temperature of 60 DEG C ~ 100 DEG C；
E, material is cooled down into drying under the conditions of 0 DEG C ~ 10 DEG C；
F, dried material will be cooled down and carry out cutting and grinding with pelleter, pulverizer is crushed to grain needed for medicinal pregelatinized starch
Diameter range.
Further, the source of raw foods grade starch of the present invention is potato or cereal starch.
Further, the quality proportioning of starch of the present invention and purified water is 1:0.06~0.32.
Further, need to heat 1 ~ 3h in the present invention before ground material mixing under the conditions of infrared, temperature is 80 ~
120℃。
Further, the frequency of ultrasonic wave is 30000Hz ~ 800000Hz in the present invention.
Further, the draw ratio of extruder screw is 16 in the present invention, and rotating speed is 120 ~ 160r/min.
The present invention uses cold water solubility（Solution temperature is 25 DEG C）Characterize the pregelatinated degree of pregelatinized starch.
For the present invention using the mobility of angle of repose characterization pregelatinized starch, angle of repose typically refers to the freedom of powder stack layer
The maximum angular that inclined-plane is formed with horizontal plane.Angle of repose is smaller, and frictional force is smaller, and mobility is better, it is considered that during θ≤30 degree
Good fluidity, whens θ≤40 degree, can meet the need for liquidity in production process.The mobility of powder to granule, capsule,
The weight differential of the preparations such as tablet and normal operating are affected.Angle of repose is tested using powder tester for overall characteristic.
The present invention characterizes the compressibility of pregelatinized starch using carr coefficients（compressibility index）, Carr
Index=（Tap density-bulk density）/ tap density, it has reacted compressibility, it is considered that, 5~15% compressibility are very
Good, 12~16% compressibility are good, and 18~21% compressibility are general, and 23~35% compressibility are poor,>40% compressibility is very poor.
Carr coefficients also reflect the mobility of pregelatinized starch simultaneously.
The present invention uses《Chinese Pharmacopoeia》The 2010 editions second pregelatinized starch quality standard included carries out comprehensive matter
Amount is examined.
It is of the invention to be had the following advantages compared with existing pregelatinized starch production technology and significant progress：
（1）Material is pre-processed using grinding hair.In process of lapping, starch granules becomes more tiny uniform, makes shallow lake
Powder is easier to be uniformly mixed, while decline the crystallinity of starch in mixed process.
（2）It can effectively solve the problem that present in currently employed single mixed at high speed unit mixing using ultrasonic vibration hybrid technology
Mixing is not uniform enough, the problem of quality is unstable, obtained material particles stable structure is uniform after mixing, and mobility is more
It is high.
（3）By infrared, ultrasonic mixing processing, gained pregelatinized starch has higher plasticity, is conducive to produce
Various products.
（4）This preparation method also have it is simple for process, it is easy to operate, the advantages that energy conservation and environmental protection.
Specific embodiment：
Further details of theory is made to other goals of the invention, technical solution and the advantageous effect of the present invention below in conjunction with embodiment
It is bright, but embodiment should not be considered as the restriction of right of the present invention.
Embodiment 1
100g food-grades cereal starch and 6g purified waters are weighed, is placed in mill and grinds 40min, infrared processing 1h, temperature is
80 DEG C, the mixed at high speed unit mixing 30min being placed under 30000Hz Ultrasonic Conditions is then transferred to, after mixing by object
Material is added in extruder, and control screw speed is 120r/min, is squeezed out at 60 DEG C, then by extruded material at 0 DEG C
It is molded after lower cooling is dry with cutting machine pelletizing, is crushed to required particle size range, finally obtain cooling water solubility is 55.2%
Pregelatinized starch.
Embodiment 2
200g food-grades cereal starch and 64g purified waters are weighed, is placed in mill and grinds 60min, infrared processing 1.5h, temperature
It is 85 DEG C, is then transferred to the mixed at high speed unit mixing 50min being placed under 40000Hz Ultrasonic Conditions, after mixing will
Material is added in extruder, and control screw speed is 120r/min, is squeezed out at 60 DEG C, then by extruded material 10
It is molded after drying is cooled down at DEG C with cutting machine pelletizing, is crushed to required particle size range, finally obtain cooling water solubility
89.7% pregelatinized starch.
Embodiment 3
300g food-grades cereal starch and 60g purified waters are weighed, is placed in mill and grinds 50min, infrared processing 1h, temperature is
100 DEG C, the mixed at high speed unit mixing 50min being placed under 50000Hz Ultrasonic Conditions is then transferred to, after mixing by object
Material is added in extruder, and control screw speed is 160r/min, is squeezed out at 100 DEG C, then by extruded material 10
It is molded after drying is cooled down at DEG C with cutting machine pelletizing, is crushed to required particle size range, finally obtain cooling water solubility is 91%
Pregelatinized starch.
Embodiment 4
200g food-grades cereal starch and 20g purified waters are weighed, is placed in mill and grinds 40min, infrared processing 2h, temperature is
90 DEG C, the mixed at high speed unit mixing 50min being placed under 80000Hz Ultrasonic Conditions is then transferred to, after mixing by object
Material is added in extruder, and control screw speed is 140r/min, is squeezed out at 100 DEG C, then by extruded material 10
It is molded after drying is cooled down at DEG C with cutting machine pelletizing, is crushed to required particle size range, finally obtain cooling water solubility
88.1% pregelatinized starch.
Embodiment 5
250g food-grades cereal starch and 25g purified waters are weighed, is placed in mill and grinds 40min, infrared processing 1.5h, temperature
It is 110 DEG C, is then transferred to the mixed at high speed unit mixing 50min being placed under 30000Hz Ultrasonic Conditions, after mixing will
Material is added in extruder, and control screw speed is 150r/min, is squeezed out at 100 DEG C, then by extruded material 0
It is molded after drying is cooled down at DEG C with cutting machine pelletizing, is crushed to required particle size range, finally obtain cooling water solubility
91.9% pregelatinized starch.
Embodiment 6
500g food-grades cereal starch and 160g purified waters are weighed, is placed in mill and grinds 60min, infrared processing 3h, temperature
It is 100 DEG C, is then transferred to the mixed at high speed unit mixing 50min being placed under 80000Hz Ultrasonic Conditions, after mixing will
Material is added in extruder, and control screw speed is 160r/min, is squeezed out at 100 DEG C, then by extruded material 0
It is molded after drying is cooled down at DEG C with cutting machine pelletizing, is crushed to required particle size range, finally obtain cooling water solubility
99.7% pregelatinized starch.
Embodiment 7
100g food-grades cereal starch and 20g purified waters are weighed, is placed in mill and grinds 50min, infrared processing 2.5h, temperature
It is 120 DEG C, is then transferred to the mixed at high speed unit mixing 50min being placed under 30000Hz Ultrasonic Conditions, after mixing will
Material is added in extruder, and control screw speed is 140r/min, is squeezed out at 80 DEG C, then by extruded material 10
It is molded after drying is cooled down at DEG C with cutting machine pelletizing, is crushed to required particle size range, finally obtain cooling water solubility
96.5% pregelatinized starch.
Embodiment 8
300g food-grades cereal starch and 96g purified waters are weighed, is placed in mill and grinds 30min, infrared processing 1.5h, temperature
It is 100 DEG C, is then transferred to the mixed at high speed unit mixing 40min being placed under 40000Hz Ultrasonic Conditions, after mixing will
Material is added in extruder, and control screw speed is 120r/min, is squeezed out at 60 DEG C, then by extruded material 10
It is molded after drying is cooled down at DEG C with cutting machine pelletizing, is crushed to required particle size range, finally obtain cooling water solubility
88.9% pregelatinized starch.
Embodiment 9
100g food-grades cereal starch and 20g purified waters are weighed, is placed in mill and grinds 40min, infrared processing 2.5h, temperature
It is 90 DEG C, is then transferred to the mixed at high speed unit mixing 40min being placed under 40000Hz Ultrasonic Conditions, after mixing will
Material is added in extruder, and control screw speed is 120r/min, is squeezed out at 60 DEG C, then by extruded material 10
It is molded after drying is cooled down at DEG C with cutting machine pelletizing, is crushed to required particle size range, finally obtain cooling water solubility
86.2% pregelatinized starch.
Embodiment 10
400g food-grades cereal starch and 80g purified waters are weighed, is placed in mill and grinds 60min, infrared processing 3.0h, temperature
It is 110 DEG C, is then transferred to the mixed at high speed unit mixing 50min being placed under 50000Hz Ultrasonic Conditions, after mixing will
Material is added in extruder, and control screw speed is 160r/min, is squeezed out at 100 DEG C, then extruded material exists
It is molded after drying is cooled down at 10 DEG C with cutting machine pelletizing, is crushed to required particle size range, finally obtain cooling water solubility
98.4% pregelatinized starch.
Embodiment 11
100g food-grades cereal starch and 60g purified waters are weighed, is placed in mill and grinds 60min, infrared processing 3h, temperature is
120 DEG C, the mixed at high speed unit mixing 50min being placed under 800000Hz Ultrasonic Conditions is then transferred to, after mixing will
Material is added in extruder, and control screw speed is 160r/min, is squeezed out at 100 DEG C, then extruded material exists
It is molded after drying is cooled down at 10 DEG C with cutting machine pelletizing, is crushed to required particle size range, finally obtain cooling water solubility
43.2% pregelatinized starch.
Embodiment 12
100g food-grades cereal starch and 15g purified waters are weighed, is placed in mill and grinds 40min, infrared processing 3h, temperature is
115 DEG C, the mixed at high speed unit mixing 30min being placed under 80000Hz Ultrasonic Conditions is then transferred to, after mixing by object
Material is added in extruder, and control screw speed is 160r/min, is squeezed out at 100 DEG C, then by extruded material at 0 DEG C
It is molded after lower cooling is dry with cutting machine pelletizing, is crushed to required particle size range, finally obtain cooling water solubility is 98.9%
Pregelatinized starch.
Comparative example 1
According to implementation described in Chinese patent CN CN102614518A embodiments, pregelatinized starch finished product is obtained.
Embodiment 13
The pregelatinized starch sample of Example 2,4,6,8,10,12 and comparative example 1,2, foundation《Chinese Pharmacopoeia 2015
Version two》The content carries out quality full inspection, the results are shown in Table 1.
Embodiment 14
Powder fluidity is tested, test method：Using powder tester for overall characteristic in whole embodiments and comparative example
Pregelatinized starch powder angle of repose be measured, the results are shown in Table 2.
Powder compressibility is tested, test method：Using use powder tester for overall characteristic to whole embodiments and comparison
Pregelatinized starch powder compressibility in embodiment is measured, and the results are shown in Table 2.
The quality test results of 1 pregelatinized starch of table
2 powder fluidity of table and compressibility test result
。
The above, the quality test results of medicinal pregelatinized starch that the present invention is produced are qualified, powder fluidity
The product prepared by other production methods can be all significantly better than with compressibility, there is significant advantage.
Claims (6)
1. a kind of preparation method of medicinal pregelatinized starch, which is characterized in that include the following steps：
A, material is weighed：Weigh a certain amount of food-grade starches and purified water；
B, the pretreatment of material：Load weighted material is placed in 40 ~ 60min of grinding in mill；
C, the mixing of material：Then ground material is placed in mixed at high speed unit, and mixed at high speed unit is made to be placed in ultrasound
Under wave environment, 30 ~ 50min is mixed, the moisture of material is 15% ~ 35% after control mixing；
D, the extrusion of material：The material mixed is added into extruder charging hopper, opens extruder, controls extruder temperature,
60oC~100oIt is squeezed out at a temperature of C；
E, by material 0oC~10oDrying is cooled down under the conditions of C；
F, dried material will be cooled down to be cut with pelleter, pulverizer is crushed to grain size model needed for medicinal pregelatinized starch
It encloses.
2. the preparation method of medicinal pregelatinized starch according to claim 1, which is characterized in that the starch for potato,
Cereal starch or their mixture.
3. the preparation method of medicinal pregelatinized starch according to claim 1, which is characterized in that the matter of starch and purified water
Amount proportioning is 1:0.06~0.32.
4. according to the preparation method of medicinal pregelatinized starch according to claim 1, it is characterised in that ground material
1 ~ 3h is heated before mixing under the conditions of infrared, temperature is 80 ~ 120oC。
5. according to the preparation method of medicinal pregelatinized starch according to claim 1, which is characterized in that the frequency of ultrasonic wave
For 30000Hz ~ 800000Hz.
6. the preparation method of medicinal pregelatinized starch according to claim 1, which is characterized in that the major diameter of extruder screw
Than being 16, rotating speed is 120 ~ 160r/min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611095337.0A CN108148144A (en) | 2016-12-02 | 2016-12-02 | A kind of improvement of the preparation method of medicinal pregelatinized starch |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611095337.0A CN108148144A (en) | 2016-12-02 | 2016-12-02 | A kind of improvement of the preparation method of medicinal pregelatinized starch |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108148144A true CN108148144A (en) | 2018-06-12 |
Family
ID=62469639
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611095337.0A Pending CN108148144A (en) | 2016-12-02 | 2016-12-02 | A kind of improvement of the preparation method of medicinal pregelatinized starch |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108148144A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112076166A (en) * | 2020-09-21 | 2020-12-15 | 湖州展望药业有限公司 | Direct-pressed starch and production method thereof |
| CN113121713A (en) * | 2021-03-31 | 2021-07-16 | 湖北人福药用辅料股份有限公司 | Pregelatinized starch and preparation method and application thereof |
Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5176931A (en) * | 1992-03-13 | 1993-01-05 | Wenger Manufacturing, Inc. | Preparation of masa flour |
| US5652010A (en) * | 1984-12-14 | 1997-07-29 | Nabisco, Inc. | Production of masa corn-based products |
| US5696186A (en) * | 1995-03-21 | 1997-12-09 | Roquette Freres | Process for improving the mutual compatibility of polymers |
| CN1610699A (en) * | 2001-12-21 | 2005-04-27 | 拜尔作物科学有限责任公司 | Pregelatinized starches and method for producing the same |
| CN102134281A (en) * | 2011-01-30 | 2011-07-27 | 广西大学 | Method for producing high-flowability pregelatinized starch |
| CN102617743A (en) * | 2012-03-31 | 2012-08-01 | 青岛明药堂医药科技开发有限公司 | Preparation method for hydroxyethyl starch |
| CN102614518A (en) * | 2012-02-04 | 2012-08-01 | 安徽山河药用辅料股份有限公司 | Method for preparing medicinal adjuvant high viscosity pregelatinized starch through physical method |
| CN104193834A (en) * | 2014-09-05 | 2014-12-10 | 湖南尔康制药股份有限公司 | Preparation method of medicinal pregelatinized starch |
| CN104262493A (en) * | 2014-09-05 | 2015-01-07 | 湖南尔康制药股份有限公司 | Preparation method and use of medicinal pregelatinized hydroxypropyl starch |
| CN105504073A (en) * | 2016-01-27 | 2016-04-20 | 河南正弘药用辅料有限公司 | Novel production technology for pregelatinized starch |
| CN106117373A (en) * | 2016-06-22 | 2016-11-16 | 陕西科技大学 | A kind of method improving starch reaction activity |
-
2016
- 2016-12-02 CN CN201611095337.0A patent/CN108148144A/en active Pending
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5652010A (en) * | 1984-12-14 | 1997-07-29 | Nabisco, Inc. | Production of masa corn-based products |
| US5176931A (en) * | 1992-03-13 | 1993-01-05 | Wenger Manufacturing, Inc. | Preparation of masa flour |
| US5696186A (en) * | 1995-03-21 | 1997-12-09 | Roquette Freres | Process for improving the mutual compatibility of polymers |
| CN1610699A (en) * | 2001-12-21 | 2005-04-27 | 拜尔作物科学有限责任公司 | Pregelatinized starches and method for producing the same |
| CN102134281A (en) * | 2011-01-30 | 2011-07-27 | 广西大学 | Method for producing high-flowability pregelatinized starch |
| CN102614518A (en) * | 2012-02-04 | 2012-08-01 | 安徽山河药用辅料股份有限公司 | Method for preparing medicinal adjuvant high viscosity pregelatinized starch through physical method |
| CN102617743A (en) * | 2012-03-31 | 2012-08-01 | 青岛明药堂医药科技开发有限公司 | Preparation method for hydroxyethyl starch |
| CN104193834A (en) * | 2014-09-05 | 2014-12-10 | 湖南尔康制药股份有限公司 | Preparation method of medicinal pregelatinized starch |
| CN104262493A (en) * | 2014-09-05 | 2015-01-07 | 湖南尔康制药股份有限公司 | Preparation method and use of medicinal pregelatinized hydroxypropyl starch |
| CN105504073A (en) * | 2016-01-27 | 2016-04-20 | 河南正弘药用辅料有限公司 | Novel production technology for pregelatinized starch |
| CN106117373A (en) * | 2016-06-22 | 2016-11-16 | 陕西科技大学 | A kind of method improving starch reaction activity |
Non-Patent Citations (8)
| Title |
|---|
| DAUD BARAKA ABDALLAH等: ""Assessment of Pregelatinized Sorghum and Maize Starches as Superior Multi-functional Excipients"", 《J PHARM INNOV》 * |
| W.R.MORRISON等: ""Properties of Damaged Starch Granules. II. Crystallinity, Molecular Order and Gelatinisation of Ball-milled Starches"", 《JOURNAL OF CEREAL SCIENCE》 * |
| 何小维等主编: "《医药用碳水化合物》", 31 January 2016, 中国轻工业出版社 * |
| 徐忠等编著: "《功能性变性淀粉》", 30 April 2010, 中国轻工业出版社 * |
| 曹志强等: ""预糊化淀粉的研究进展"", 《大众科技》 * |
| 李庭龙等: ""物理法淀粉改性研究进展"", 《广西民族大学学报（自然科学版）》 * |
| 童丹等编著: "《马铃薯变性淀粉加工技术》", 31 October 2015, 武汉大学出版社 * |
| 郑俊民等: "《药用高分子材料学》", 31 January 2009, 中国医科出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112076166A (en) * | 2020-09-21 | 2020-12-15 | 湖州展望药业有限公司 | Direct-pressed starch and production method thereof |
| CN113121713A (en) * | 2021-03-31 | 2021-07-16 | 湖北人福药用辅料股份有限公司 | Pregelatinized starch and preparation method and application thereof |
| CN113121713B (en) * | 2021-03-31 | 2023-08-15 | 湖北人福药用辅料股份有限公司 | Pregelatinized starch and preparation method and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Huang et al. | Effects of superfine grinding on properties of sugar beet pulp powders | |
| CN102134281A (en) | Method for producing high-flowability pregelatinized starch | |
| CN105732827B (en) | A kind of preparation method that rice starch is nanocrystalline | |
| US20140017319A1 (en) | Process for producing cellulose derivatives of high bulk density and good flowability | |
| CN108433113A (en) | A kind of method that ultrasonication prepares citrus fruit fibres | |
| CN108853038A (en) | A kind of paracetamol tablets and its preparation process | |
| CN104193834B (en) | A kind of preparation method of medicinal pregelatinized Starch | |
| CN108148144A (en) | A kind of improvement of the preparation method of medicinal pregelatinized starch | |
| KR20180066723A (en) | Method of manufacturing carboxymethyl cellulose particles, carboxymethyl cellulose particles and absorbent articles including the same | |
| CN101390840B (en) | Production method of high-assay calcium ascorbate granules capable of directly being compressed | |
| CN102772446A (en) | Industrialized production process of anti-tumor medicine lentinan capsules | |
| CN103202817B (en) | Preparation method for mannitol grains capable of being directly pressed | |
| CN115671299A (en) | Preparation method of microcrystalline cellulose anhydrous calcium hydrophosphate co-processed product | |
| CN110004195A (en) | A kind of method that enzymatic assisted extrusion prepares starch octenyl succinate anhydride | |
| CN104263782B (en) | A kind of drug excipient and preparation method thereof | |
| CN102294033A (en) | Production process of spherical lactose particle | |
| CN106084078A (en) | A kind of method using dry process of preparation of cationic starch | |
| CN108517713A (en) | The preparation method of papermaking special-purpose nanometer talcum powder | |
| CN104055821B (en) | A kind of preparation method of Herba Epimedii broken wall preparation | |
| CN109288952A (en) | Smilax china L ball and its preparation process | |
| CN104055835B (en) | A kind of beautiful millettia root broken wall preparation | |
| CN104055819B (en) | A kind of chrysanthemum broken wall preparation | |
| CN109315691A (en) | A kind of coarse cereals recombination rice of hypoglycemia patient and preparation method thereof | |
| CN107669652A (en) | A kind of preparation method for extracting species high-viscosity material particle | |
| CN113121713B (en) | Pregelatinized starch and preparation method and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20180612 |
|
| WD01 | Invention patent application deemed withdrawn after publication |