CN108144588A - A kind of preparation method of L-Trp polymeric material - Google Patents
A kind of preparation method of L-Trp polymeric material Download PDFInfo
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- CN108144588A CN108144588A CN201711197055.6A CN201711197055A CN108144588A CN 108144588 A CN108144588 A CN 108144588A CN 201711197055 A CN201711197055 A CN 201711197055A CN 108144588 A CN108144588 A CN 108144588A
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- parts
- trp
- polymeric material
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- toluene
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
- B01J20/26—Synthetic macromolecular compounds
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
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- Organic Chemistry (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Abstract
The present invention relates to a kind of preparation methods of L tryptophans polymeric material.It is formed by specified weight number, including acrylate, polyvinyl alcohol, ammonium persulfate, toluene, polymerization monomer composition, temperature reaction, product is to obtain L tryptophan polymeric materials after processing.
Description
Technical field
The present invention relates to a kind of auxiliary agent of purifying L-tryptophan, especially a kind of preparation side of L-Trp polymeric material
Method.
Background technology
L-Trp is a kind of nutritional supplement for people.Antioxidant.Tryptophan is the important neurotransmitter -5- of human body
The precursor of hydroxytryptamine is one of essential amino acid of human body；For maternal nutritional tonic and the special milk powder of newborn child；For niacin
Deficiency disease（Pellagra）Medicine；As sedative, adjust the spiritual rhythm and pace of moving things, improve sleep；Animal can be promoted for animal
Feeding weakens stress reaction, improves animal sleep, can also increase the antibody of fetus and young baby, improve milk animal lactation.Reduce day
Grain high-quality protein dosage saves feed cost, reduces dietary protein feed dosage, saves formulation space etc..
CN101565396B discloses a kind of process for refining of L-Trp：By the use of the mixed solvent of water and propyl alcohol as molten
Matchmaker dissolves L-Trp crude product, and after L-Trp crude product is completely dissolved, 100~120min is reacted at 50~80 DEG C, filtered
Transparent, the clear solution containing product is obtained, solution removing moisture is obtained into wet L-Trp, drying later can obtain L-
Tryptophan fine work.
CN103709091A discloses a kind of method for extracting L-Trp, includes the following steps：1）L-Trp will be contained
Solution be concentrated by evaporation to every liter containing 30-95 grams of L-Trp；2）With the dosage of 4-12 moles of organic acid of every mole of L-Trp
Organic acid is added in, continues to be evaporated to every L containing 200-400 grams of L-Trp；3）It crystallizes and obtains L-Trp crude product, 4）To the L-
Tryptophan crude product adds water, and after high-temperature process, crystallization obtains L-Trp sterling.
Existing L-Trp purifying technique has the shortcomings that complicated for operation, when consumption energy consumption is big, therefore it provides a kind of available
In the high-efficiency adsorbent of L-Trp, arranging in pairs or groups other methods or is individually purified, and can play simplified purifying technique, section time
The effect of energy.
Invention content
The purpose of the present invention is：There is provided a kind of preparation method of L-Trp polymeric material, it is characterised in that prepare step
Suddenly include：
By weight, following components are uniformly mixed, are warming up to 75-95 DEG C, reacted 8-20h, remove pore after reaction
Agent toluene is to get to L-Trp polymeric material.
Ingredients weight parts
100 parts of acrylate
8-20 parts of monomer composition of polymerization
1-5 parts of ammonium lauryl sulfate
0.5-2 parts of ammonium persulfate
400-800 parts of water
25-45 parts of toluene
By weight, the polymerization monomer composition, consisting of：
Ingredients weight parts
100 parts of ethyl alcohol
0.01-0.1 parts of -3 (2H) -one of 4- pi-allyl -6- methyl -4,5- dihydrogen dazins
1-5 parts of 1,4- dially phthalates
N- (4- sulfoamidos phenyl) 0.1-0.5 parts of acrylamide
0.1-0.5 parts of 2- trimethylsiloxy group -1,1,1,5,5,5- hexafluoros amyl- 2- alkene -4- ketone
.5-1.5 parts of tristyrylphenol polyoxyethylene ether phosphoesterase 30
The acrylate, polyvinyl alcohol, ammonium persulfate, toluene, 4- pi-allyl -6- methyl -4,5- dihydrogen dazins -3 (2H) -
Ketone, Isosorbide-5-Nitrae-dially phthalate, N- (4- sulfoamidos phenyl) acrylamide,-trimethylsiloxy group -1,1,1,5,5,5-
The amyl- 2- alkene -4- ketone of hexafluoro, tristyrylphenol polyoxyethylene ether phosphate is commercial product.
The product of the present invention has the advantages that：
The adsorbent product that the present invention is produced has preferable heat-resisting endurance, not mutability, can stablize permanent performance and inhale
Attached effect；Adsorption rate is fast, and adsorption capacity is big, and the L-Trp product of high-purity can be made.
Specific embodiment
Following instance is only to further illustrate the present invention, and is not limitation the scope of protection of the invention.
Embodiment 1
Step 1. prepares polymerization monomer composition, and every part represents 1Kg mass, consisting of：
Ingredients weight parts
100 parts of ethyl alcohol
- 3 0.05 part of (2H) -one of 4- pi-allyl -6- methyl -4,5- dihydrogen dazins
2.5 parts of 1,4- dially phthalates
N- (4- sulfoamidos phenyl) 0.2 part of acrylamide
0.3 part of the amyl- 2- alkene -4- ketone of 2- trimethylsiloxy group -1,1,1,5,5,5- hexafluoros
1 part of tristyrylphenol polyoxyethylene ether phosphate
Step 2. prepares adsorbent product, and every part represents 1Kg mass, consisting of：
Ingredients weight parts
100 parts of acrylate
14 parts of monomer composition of polymerization
1.5 parts of ammonium lauryl sulfate
0.75 part of ammonium persulfate
600 parts of water
35 parts of toluene
Said components are uniformly mixed, are warming up to 85 DEG C, react 14h, remove pore-foaming agent toluene after reaction to get to L- colors
Propylhomoserin polymeric material.
Embodiment 2
Step 1. prepares polymerization monomer composition, and every part represents 1Kg mass, consisting of：
Ingredients weight parts
100 parts of ethyl alcohol
- 3 0.01 part of (2H) -one of 4- pi-allyl -6- methyl -4,5- dihydrogen dazins
1 part of 1,4- dially phthalates
N- (4- sulfoamidos phenyl) 0.1 part of acrylamide
0.1 part of the amyl- 2- alkene -4- ketone of 2- trimethylsiloxy group -1,1,1,5,5,5- hexafluoros
.5 parts of tristyrylphenol polyoxyethylene ether phosphoesterase 30
Step 2. prepares adsorbent product, and every part represents 1Kg mass, consisting of：
Ingredients weight parts
100 parts of acrylate
8 parts of monomer composition of polymerization
1 part of ammonium lauryl sulfate
0.5 part of ammonium persulfate
400 parts of water
25 parts of toluene
Said components are uniformly mixed, are warming up to 75 DEG C, react 8h, remove pore-foaming agent toluene after reaction to get to L- colors
Propylhomoserin polymeric material.
Embodiment 3
Step 1. prepares polymerization monomer composition, and every part represents 1Kg mass, consisting of：
Ingredients weight parts
100 parts of ethyl alcohol
- 3 0.1 part of (2H) -one of 4- pi-allyl -6- methyl -4,5- dihydrogen dazins
5 parts of 1,4- dially phthalates
N- (4- sulfoamidos phenyl) 0.5 part of acrylamide
0.5 part of the amyl- 2- alkene -4- ketone of 2- trimethylsiloxy group -1,1,1,5,5,5- hexafluoros
1.5 parts of tristyrylphenol polyoxyethylene ether phosphate
Step 2. prepares adsorbent product, and every part represents 1Kg mass, consisting of：
Ingredients weight parts
100 parts of acrylate
20 parts of monomer composition of polymerization
5 parts of ammonium lauryl sulfate
2 parts of ammonium persulfate
800 parts of water
45 parts of toluene
Said components are uniformly mixed, are warming up to 95 DEG C, react 20h, remove pore-foaming agent toluene after reaction to get to L- colors
Propylhomoserin polymeric material.
Comparative example 1
- 3 (2H) -one of 4- pi-allyl -6- methyl -4,5- dihydrogen dazin is added without, other conditions are the same as embodiment 1.
Comparative example 2
Isosorbide-5-Nitrae-dially phthalate is added without, other conditions are the same as embodiment 1.
Comparative example 3
N- (4- sulfoamidos phenyl) acrylamide is added without, other conditions are the same as embodiment 1.
Comparative example 4
2- trimethylsiloxy groups -1,1 are added without, the amyl- 2- alkene -4- ketone of 1,5,5,5- hexafluoro, other conditions are the same as embodiment 1.
Comparative example 5
Tristyrylphenol polyoxyethylene ether phosphate is added without, other conditions are the same as embodiment 1.
Embodiment 4
L-Trp crude product after the decoloration for being about 95% by mass percent concentration is passed through equipped with 500g embodiments 1-3 and right
The 1000mL exchange columns of ratio 1-5L- tryptophan polymeric materials, temperature 70 C, flow velocity 0.5BV/h, under the conditions of adsorb purification,
With the mass percentage of gas chromatographic detection efflux, it is shown in Table 1.
Table 1：The L-Trp that different process is produced adsorbed with polymeric material after L-Trp product purity.
Claims (3)
1. a kind of preparation method of L-Trp polymeric material, it is characterised in that composition is by weight：
Ingredients weight parts
100 parts of acrylate
8-20 parts of monomer composition of polymerization
1-5 parts of ammonium lauryl sulfate
0.5-2 parts of ammonium persulfate
400-800 parts of water
25-45 parts of toluene.
2. a kind of preparation method of L-Trp polymeric material according to claim 1, it is characterised in that by weight,
The polymeric monomer composite forms：
Ingredients weight parts
100 parts of ethyl alcohol
0.01-0.1 parts of -3 (2H) -one of 4- pi-allyl -6- methyl -4,5- dihydrogen dazins
1-5 parts of 1,4- dially phthalates
N- (4- sulfoamidos phenyl) 0.1-0.5 parts of acrylamide
0.1-0.5 parts of 2- trimethylsiloxy group -1,1,1,5,5,5- hexafluoros amyl- 2- alkene -4- ketone
.5-1.5 parts of tristyrylphenol polyoxyethylene ether phosphoesterase 30.
A kind of 3. preparation method of L-Trp polymeric material according to claim 1, it is characterised in that preparation method
For：Said components are uniformly mixed, are warming up to 75-95 DEG C, react 8-20h, remove after reaction pore-foaming agent toluene to get to
L-Trp polymeric material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711197055.6A CN108144588A (en) | 2017-11-25 | 2017-11-25 | A kind of preparation method of L-Trp polymeric material |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711197055.6A CN108144588A (en) | 2017-11-25 | 2017-11-25 | A kind of preparation method of L-Trp polymeric material |
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| Publication Number | Publication Date |
|---|---|
| CN108144588A true CN108144588A (en) | 2018-06-12 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711197055.6A Withdrawn CN108144588A (en) | 2017-11-25 | 2017-11-25 | A kind of preparation method of L-Trp polymeric material |
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| Country | Link |
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| CN (1) | CN108144588A (en) |
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2017
- 2017-11-25 CN CN201711197055.6A patent/CN108144588A/en not_active Withdrawn
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| PB01 | Publication | ||
| PB01 | Publication | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20180612 |