CN108143771A - A kind of Chinese medicine composition for preventing and treating cold - Google Patents
A kind of Chinese medicine composition for preventing and treating cold Download PDFInfo
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- CN108143771A CN108143771A CN201611107207.4A CN201611107207A CN108143771A CN 108143771 A CN108143771 A CN 108143771A CN 201611107207 A CN201611107207 A CN 201611107207A CN 108143771 A CN108143771 A CN 108143771A
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- chinese medicine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/59—Menispermaceae (Moonseed family), e.g. hyperbaena or coralbead
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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- Natural Medicines & Medicinal Plants (AREA)
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- Animal Behavior & Ethology (AREA)
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Abstract
The present invention provides a kind of Chinese medicine for preventing and treating cold, is made of the component of following masses part：3400 ~ 4400 parts of copper coin root, 240 ~ 340 parts of Radix Glycyrrhizae, 25 ~ 45 parts of radix scutellariae.Copper coin root is worn into fine powder and coarse powder respectively；Coarse powder is mixed with radix scutellariae, Radix Glycyrrhizae, is added water to cook twice, and then collecting decoction filters, then be condensed into thick paste, is finally uniformly mixed with above-mentioned fine powder, obtains the Chinese medicine composition of prevention and treatment cold.The Chinese medicine composition curative effect significant curative effect without side-effects of prevention and treatment cold provided by the invention, and it is at low cost, it is simple for production.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition more particularly to a kind of Chinese medicine compositions for preventing and treating cold, belong to
Biotechnology.
Background technology
Common cold, the traditional Chinese medical science claim " to catch cold ", are a kind of respiratory tract common diseases as caused by a variety of viruses, wherein 30~50%
It is to be caused by the rhinovirus of certain serotype.Popularity cold, is the Acute respiratory infectious disease as caused by influenza virus；Virus
It is present in the respiratory tract of patient, others is given through droplet infection in patient's cough, sneezing.
Common cold medicine is mostly Western medicine at present, take after these medicines can only headache caused by respite cold, chilly,
The symptoms such as fever, runny nose, cough, while the side effects such as convulsions and angiocarpy, breathing, nervous system can be also accompanied by, be not suitable for
Human body is long-term or repeatedly takes.
Invention content
The problems such as to overcome drug of the prior art that cannot reach curative effect and big side effect, it is an object of the invention to carry
Supplied it is a kind of prevent and treat cold Chinese medicine composition, for prevent and treat cold, bronchitis, laryngitis, stomatitis,
Angina.
The present invention is realized by following technical proposal：A kind of Chinese medicine for preventing and treating cold, it is characterised in that including under
The component of row mass parts：
3400~4400 parts of copper coin root
240~340 parts of Radix Glycyrrhizae
25~45 parts of radix scutellariae.
The present invention provides a kind of Chinese medicine for preventing and treating cold, is made of the component of following masses part：
3950 parts of copper coin root
280 parts of Radix Glycyrrhizae
35 parts of radix scutellariae.
Wherein, copper coin root, nature and flavor：It is cool, bitter；Enter Liver Channel.With the effect of clearing heat and detoxicating, wind dispelling relieves pain.Radix Glycyrrhizae：Property
Taste：It is flat, it is sweet in flavor；Return 12 warps.There are removing toxic substances, eliminating the phlegm, analgesic, spasmolysis so that the pharmacological actions such as anticancer.Radix scutellariae：Nature and flavor：Hardship is trembled with fear；
Return lung, courage, spleen, large intestine, small intestinl channel.It cures mainly：Heat-clearing and damp-drying drug, purging intense heat and detonicating, hemostasis, tocolysis, blood pressure lowering.
The Chinese medicine of prevention and treatment cold of the present invention is made by following method：
（1）By following mass parts feeding：
3400~4400 parts of copper coin root
240~340 parts of Radix Glycyrrhizae
25~45 parts of radix scutellariae；
（2）Take step（1）1/20 part of standby copper coin root total amount, be ground into 100 targeted fine powders；Remaining copper coin root is crushed again
Into coarse powder；By the coarse powder and step（1）Standby radix scutellariae, Radix Glycyrrhizae mixing, by the amount that solid-liquid mass ratio is 1 ︰ 7.5, water is added to carry out
It decocts, decocting liquid is poured out after boiling 2 hours, then by the amount that solid-liquid mass ratio is 1 ︰ 5, water is added to be decocted again, after boiling 2 hours
Decocting liquid is poured out, merges decocting liquid twice, filtering is condensed into thick paste, is finally uniformly mixed with above-mentioned copper coin root fine powder, obtains prevention
With the Chinese medicine for the treatment of cold.
Suitable customary adjuvant is added in the present invention provides said medicine, doctor is made by conventional method of the prior art
Acceptable any preparation on medicine, such as tablet, decoction, capsule, soft capsule, particle electuary, pill, oral liquid preparation.
The effect and advantage that the present invention has：
Traditional Chinese medicine thinks, cold, bronchitis, laryngitis, angina these diseases are mostly because the perverse trends such as diseases caused by external factors ailment said due to cold or exposure or heat toxin are invaded
Violate body and cause.The Chinese medicine composition of prevention and treatment cold provided by the invention is as the main component with copper coin root, has heat-clearing
Removing toxic substances, wind-expelling pain-stopping, inflammation-diminishing and cough-controlling and other effects；Can be used for prevention and treatment cold can play unique effect, and radix scutellariae, Radix Glycyrrhizae are
Ministerial drug energy principal drug assistance copper coin root is clearing heat and detoxicating, expelling phlegm and arresting coughing；Have to common common cold virus and popular common cold virus stronger
Antivirus action for treating the symptoms such as caused headache, chilly, fever, runny nose, cough of catching cold, and can be used to prevent and control
It cures the wound wind, bronchitis, laryngitis, stomatitis, angina.It is and low, safe, without side-effects with fast, recurrence rate is restored
Significant curative effects are waited, and at low cost, it is simple for production.
（1）By following mass parts feeding：
3950 parts of copper coin root, 280 parts of Radix Glycyrrhizae, 35 parts of radix scutellariae；
（2）Take step（1）Standby 158 parts of the copper coin root of institute, is ground into 100 targeted fine powders；Remaining copper coin root is ground into coarse powder again；
Coarse powder and step（1）The standby radix scutellariae of institute, Radix Glycyrrhizae mix, and by the amount that solid-liquid mass ratio is 1 ︰ 7.5, water are added to be decocted, is boiled 2 hours
After pour out decocting liquid, then by the amount that solid-liquid mass ratio is 1 ︰ 5, water is added to be decocted again, decocting liquid is poured out after boiling 2 hours, merging
Then decocting liquid twice filters, then be condensed into thick paste, with above-mentioned fine powder after mixing finally, adds in suitable customary adjuvant, presses
Chinese medicine tablet of the tablet to get prevention and treatment cold is made in conventional method of the prior art.
Embodiment 2
（1）By following mass parts feeding：
3500 parts of copper coin root, 320 parts of Radix Glycyrrhizae, 40 parts of radix scutellariae；
（2）Take step（1）Standby 140 parts of the copper coin root of institute, is ground into 100 targeted fine powders；Remaining copper coin root is ground into coarse powder again；
Coarse powder and step（1）The standby radix scutellariae of institute, Radix Glycyrrhizae mix, and by the amount that solid-liquid mass ratio is 1 ︰ 7.5, water are added to be decocted, is boiled 2 hours
After pour out decocting liquid, then by the amount that solid-liquid mass ratio is 1 ︰ 5, water is added to be decocted again, decocting liquid is poured out after boiling 2 hours, merging
Then decocting liquid twice filters, then be condensed into thick paste, with above-mentioned fine powder after mixing finally, adds in suitable customary adjuvant, presses
Capsule of the capsule to get prevention and treatment cold is made in conventional method of the prior art.
As a result the Chinese medicine of prevention and treatment cold that the embodiment of the present invention 1 provides shows its toxicity through acute toxicity test
It is very low, LD50 is not measured, therefore carries out the maximal tolerance dose of disposable gavage（MTD）It measures, MTD>7.5g/kg（It is equivalent to copper
Money root 98.75g/kg）, reached clinical recommended amounts 0.048g/kg/d（Copper coin root 0.63g/kg/d）156 times or more.
Test objective：After observing the disposable gavage of Chinese medicine of prevention and treatment cold that the embodiment of the present invention 1 provides, to small
Acute toxic reaction produced by mouse and death condition.
For reagent product：The Chinese medicine tablet of the prevention and treatment cold of the embodiment of the present invention 1, every gram is equivalent to root containing copper coin
13.2g。
Experimental animal：ICR mouse, half male and half female, by Yunnan Province's natural drug pharmacology emphasis reality
Room offer is provided（Quality certification number：Yunnan is dynamic in fact to demonstrate,prove word 9806）.
Test method：
1st, the preparation of drug：The Chinese medicine tablet 8.0g of the prevention and treatment cold of the embodiment of the present invention 1 is taken, adding in mass concentration is
0.5% sodium carboxymethylcellulose obtains suspension to 20mL；
2nd, the acute toxicity test of gastric infusion：Healthy ICR kind mouse 20 of the weight for 18~22g is selected, half male and half female is used
The liquid that above-mentioned 1 step is configured to is by maximum volume 0.3mL/10g, as 7.5g/kg（It is equivalent to copper coin root 98.75g/kg）,
Disposable gavage when noon 5, fasting 8h before administration are observed continuously 14 days after administration, record animal poisoning and death condition.Experiment
As a result it see the table below 1：
As a result：It after 20 intragastric administration on mice administrations, is observed continuously within 14 days, has no that any toxic reaction occurs in animal, all animals are deposited
Living, freely, feed drinking-water and stool and urine are normal, and ordinary circumstance is good for activity.
Conclusion：The maximal tolerance dose of intragastric administration on mice tablet for preventing common cold is more than 7.5g/kg（It is equivalent to copper coin root 98.75g/kg）,
Recommend bed dosage 0.048g/kg/d up to facing（Copper coin root 0.63g/kg/d）156 times or more, also have no overt toxicity react.It says
The Chinese native medicine security of bright human oral's prevention and treatment cold provided by the invention is big.
The capsule of the prevention and treatment cold of above-described embodiment 2 is taken, for following clinical：
The capsule of the prevention and treatment cold of above-described embodiment 2 is taken, for following clinical：
First, observation plan
1st, observing time：Annual selection winter, three months spring are observed, i.e. the cold before census and registration medication in December and stream
Feel number of the infected, in second year one, two, March for medication observing time.
2nd, subjects：Select the men and women, old and young in the similar area of weather conditions.
3rd, observation method：To drug prophylaxis group or blank control group registration cold, flu episode number of cases before medication, and
Observation cold and incidence during influenza during medication.
4th, it is grouped：First group of totally 481 people：239 people of drug prophylaxis group, 242 people of blank control group；Second group of totally 571 people：In advance
Anti- 214 people of medication group, 357 people of eucalyptus leaves soup control group.
5th, make drug prophylaxis observation during influenza pandemic.
2nd, instructions of taking
1st, in drug prophylaxis group, do not occur symptom by preventive dose：Everyone takes orally the glue containing Chinese medicine 16g every time 2 times a day
Capsule takes once for every 10 days, if in the influenza pandemic phase, even served 5~10；There is symptom and press treatment dosage：3 times a day, every time
The oral capsule containing Chinese medicine 16g.
2nd, blank control group：Everyone is daily with 25 grams of copper coin root, radix berberidis（Nature and flavor：Hardship is trembled with fear.Enter liver, stomach, large intestine
Through.It cures mainly：Heat-clearing and damp-drying drug, purging intense heat and detonicating have antibacterial or bactericidal effect）The decoction of 5 grams of mixing decoctings, takes once for every 10 days；If
In the influenza pandemic phase, 5~7 days are even served.
3rd, eucalyptus leaves soup control group：Everyone is daily with eucalyptus leaves（There is disinfection）5 grams of 15 grams, Radix Glycyrrhizae mixing decoctings
Decoction, take once within every 10 days；If in the influenza pandemic phase, 5~7 days are even served.
3rd, result is observed
Through 18 batches of medication observations in 6 months, no matter catch cold in drug prophylaxis group of the invention, the moon incidence and total incidence of influenza
It is markedly inferior to control group, during observation, it was found that under tracheitis number of the infected is gradual in drug prophylaxis group of the invention
Drop.
4th, conclusion
It is observed by long term clinical results, two groups of curative effects compare, and drug prophylaxis group curative effect is high, average attack rate 15.0%, eucalyptus
Leaf soup control group average attack rate is 99.4% person-time.From clinical testing data it could be assumed that：It is provided by the invention to prevent and control
Cure the wound wind Chinese medicine composition have remarkable result.
Claims (3)
1. a kind of Chinese medicine for preventing and treating cold, it is characterised in that be made of the component of following masses part：
3400~4400 parts of copper coin root
240~340 parts of Radix Glycyrrhizae
25~45 parts of radix scutellariae.
A kind of 2. method for preparing the Chinese medicine that cold is prevented and treated described in claim 1, it is characterised in that pass through following each step
Suddenly：
（1）By following mass parts feeding：
3400~4400 parts of copper coin root
240~340 parts of Radix Glycyrrhizae
25~45 parts of radix scutellariae；
（2）Take step（1）1/20 part of standby copper coin root gross mass, be ground into 100 targeted fine powders；Again by remaining copper coin root powder
It is broken into coarse powder；By the coarse powder and step（1）Standby radix scutellariae, Radix Glycyrrhizae mixing, by the amount that solid-liquid mass ratio is 1 ︰ 7.5, add water into
Row decocts, and decocting liquid is poured out after boiling 2 hours, then by the amount that solid-liquid mass ratio is 1 ︰ 5, water is added to be decocted again, is boiled 2 hours
After pour out decocting liquid, merge decocting liquid twice, filtering is condensed into thick paste, is finally uniformly mixed, obtains pre- with above-mentioned copper coin root fine powder
Anti- and treatment cold Chinese medicine.
3. according to the method described in claim 2, it is characterized in that：In step（2）In the Chinese medicine of gained prevention and treatment cold,
Suitable customary adjuvant is added in, pharmaceutically acceptable preparation is made by conventional method of the prior art.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611107207.4A CN108143771A (en) | 2016-12-06 | 2016-12-06 | A kind of Chinese medicine composition for preventing and treating cold |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611107207.4A CN108143771A (en) | 2016-12-06 | 2016-12-06 | A kind of Chinese medicine composition for preventing and treating cold |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108143771A true CN108143771A (en) | 2018-06-12 |
Family
ID=62469707
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611107207.4A Pending CN108143771A (en) | 2016-12-06 | 2016-12-06 | A kind of Chinese medicine composition for preventing and treating cold |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108143771A (en) |
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2016
- 2016-12-06 CN CN201611107207.4A patent/CN108143771A/en active Pending
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Application publication date: 20180612 |
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| WD01 | Invention patent application deemed withdrawn after publication |