CN108142948A - One kind loosens sleeping composition and preparation method thereof and preparation - Google Patents
One kind loosens sleeping composition and preparation method thereof and preparation Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/065—Microorganisms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/21—Streptococcus, lactococcus
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a kind of preparation methods for loosening sleeping composition, are by carrying out subcritical abstraction and fermentation operation to tealeaves, carrying out infusion extraction, then be evaporated under reduced pressure and be spray-dried respectively to traditional Chinese medicine ingredients such as spina date seeds, obtain loosening sleeping composition.The preparation method is safe, controllability is strong, and the obtained sleeping composition that loosens substantially has no toxic side effect, and has effects that preferably to loosen, sleeping.
Description
Technical field
The invention belongs to healthy food fields, and in particular to one kind loosens sleeping composition and preparation method thereof and preparation.
Background technology
With the quickening of modern life rhythm, the exacerbation of life and work pressure, social insomniac is increasing now, loses
Dormancy has become a kind of potential threat for health.2017 Chinese sleep quality reports --- based on Huawei's sport health big data
It has been shown that, Chinese generally face sleeping problems, and 67% user's sound sleep is insufficient, also have sleep is too short, fall asleep too late, dreaminess, night it is easy
It wakes up, situation irregular, that sleep-respiratory quality is bad of working and resting.Due to being chronically at dyssomnia state, it be easy to cause immune work(
Can decline, is digestive function and hypogona dism, decrease of memory, short-tempered, also easily induce hypertension, coronary heart disease, apoplexy,
The problems such as diseases such as diabetes, women is then also easy to produce dry skin, menstrual disorder.The traditional Chinese medical science thinks that the etiology and pathogenesis of insomnia is defended for battalion
It becomes estranged, imbalance of yin and yang, sick position and the heart, liver, courage, spleen, stomach, kidney are in close relations.
Brain wave can be used for the sleep relaxation state of appraiser.Human brain launches frequency in 0.5-3Hz under the state of sleeping soundly
δ waves, θ wave of the frequency in 4-7Hz is launched under doze state, launches the α waves of 8-13Hz under ground state waking to loosen,
Launch the β waves of 14Hz under the excitedly state that wakes.When α wave brain wave quantity increases, show that people is in " loosening " state.
When people, which are in, regains consciousness, thinks deeply or take active action state, brains will send out β E.E.Gs.Research confirms that L-thiamine can promote
Brain surface α waves generate, θ wave number amounts when human body being made to generate happy, pleasant feeling, but not being caused in sleep state
Increase.L-thiamine is taken, can allow people's " brains is very awake ", " mood becomes stable ", " be easy to generate inspiration ".Absorb GABA
When, there is the phenomenon that apparent increase of α waves but significantly suppressed β waves, so taking GABA, the calm brain of meeting reduces pressure, stresses
It is calm.
Suanzaoren decoction is documented in《Synopsis Golden Chamber》, complete is just spina date seed 30g, Radix Glycyrrhizae 3g, rhizoma anemarrhenae 9g, Poria cocos 6g, Rhizoma Chuanxiong 6g,
With nourishing blood and tranquilization, the effect of clearing heat and relieving fidgetness.Main ingredient：Spina date seed, nourishing the liver blood, tranquilizing mind；Adjuvant：Rhizoma Chuanxiong raises liver blood, pungent to dissipate
It is soothing the liver；Adjutant：Poria cocos, rhizoma anemarrhenae, tonifying spleen calming heart, nourishing Yin and clearing heat.Make medicine：Radix Glycyrrhizae, coordinating the drug actions of a prescription.Curing mainly consumptive disease with restlessness must not sleep,
Palpitation and night sweat is had a dizzy spell, dry throat.The party has long edible history, and wherein Rhizoma Chuanxiong and rhizoma anemarrhenae is unusable in commonly
In food.
Chinese patent CN201410501131 discloses a kind of antitoxic heart-soothing and sedative, the health products for helping sleep, which provides one
Kind antitoxic heart-soothing and sedative, the health products for helping sleep, have the advantages that pure plant or extract combination form, without any toxicity and side effects, together
When to calm the nerves and assisting sleep have preferable effect.But the research of no extracting method is had no, also without animal or human experimentation work(
It can evaluation.
After tealeaves is generally considered with sedative action, but part drinking person takes tealeaves, easily causes and have difficulty in going to sleep, is spiritual
Phenomena such as excited, reason may be with the ingredient partly calmed the nerves while also with alkaloids such as caffeines to nerve in tealeaves
There is the ingredient of stimulation.Chinese patent CN201510230130 is disclosed extracts biology from low-grade tea and tea making leftover bits and pieces
The method of active material, the method which extracts bioactive substance from low-grade tea and tea making leftover bits and pieces, including following
Step：1）Caffeine is extracted from raw material；2）Extract tea polyphenols；3）Extract tea polysaccharide；4）Extract mono- amino fourth of theanine and γ
Acid；5）Extract extract and extract remainder protein feed；6）Extract separation obtains high-purity lutein ester and chlorophyll.The present invention
Method is at low cost, environmentally protective, is suitble to large-scale production.But extraction of substance type is more, and L-thiamine and γ-aminobutyric acid carry
It takes rate low, and yield cannot be controlled.It is used in extraction process to poisonous and harmful reagent, is not suitable for field of food.
Invention content
It is high, safe one of the objects of the present invention is to provide a kind of controllability for overcome the deficiencies in the prior art
The preparation method for loosening sleeping composition.
An object of the present invention is achieved through the following technical solutions：
A kind of preparation method for loosening sleeping composition, includes the following steps：
1）Using solid-liquid ratio as 1:（5-10）PH=7 water for solvent, subcritical abstraction operation and fermentation operation are carried out to tealeaves,
Obtain the first crude extract；Fermenting microbe is one or more in galactococcus, streptococcus and lactobacillus；Wherein, subcritical abstraction
Process conditions be：Pressure is 0.6-0.8MPa, temperature is 45-55 DEG C；The process conditions of fermentation are：The inoculum concentration of strain is 1-
5%, 32 DEG C -37 DEG C of fermentation temperature；
2）Take 30 parts of spina date seed, 2.5-3.5 parts of Radix Glycyrrhizae, 8-10 parts of lily, 4-8 parts of Poria cocos, 4-8 parts of peach kernel, 4-8 parts of cape jasmine, with
Solid-liquid ratio is 1:（5-10）PH=7 water be solvent infusion extraction, obtain the second crude extract；
3）First crude extract and the second crude extract respectively at 80-90 DEG C are evaporated under reduced pressure, are spray-dried, with（1-10）: 3
Ratio mixing, obtain loosening sleeping composition；The technological parameter being wherein spray-dried is：100-120 DEG C of inlet air temperature, outlet air
70-80 DEG C of temperature.
Further, step 1）In, fermentation operation is carried out again after first carrying out subcritical abstraction operation.
Further, step 1）In, subcritical abstraction operation is carried out after first being fermented again.
Further, step 1）In, the sodium glutamate for adding in tealeaves weight 5-20wt% ferments.
Further, step 1）In, strain is pressed by galactococcus, streptococcus and lactobacillus（1-2）:（1-2）:10 weight ratio
Composition.
The second object of the present invention is to provide that above-mentioned preparation method obtains loosens sleeping composition.
The third object of the present invention is to provide a kind of preparation for loosening sleeping composition.
The third object of the present invention adopts the following technical scheme that realization：
One kind loosens sleeping preparation, is made including following components by weight：4-8 parts above-mentioned to loosen sleeping composition, 1-3
Part maltodextrin and 1-3 parts of microcrystalline celluloses.
Compared with prior art, the beneficial effects of the present invention are：
1）Sleeping preparation provided by the invention is to loosen sleeping ingredient, i.e. L-thiamine and gamma-amino in selective extraction tealeaves
Butyric acid also known as 4-Aminobutanoicacid with reference to integration of drinking and medicinal herbs, loosen and determine the traditional Chinese medicine ingredients of gas, can effectively improve the sleep matter of user
Amount；Experiencing experiment display through human body, there is good sleeping to loosen effect；
2）The present invention makes by using fermentation and the mode of subcritical abstraction in active ingredient and the suanzaoren decoction side in tealeaves
The mutually auxiliary phase separation of active ingredient improves the effect of this loosens sleeping composition and acts on；
3）The controllability of the preparation method provided by the invention for loosening sleeping composition is higher, can be by controlling zymotechnique and Asia
The sequencing and design parameter of critical extraction process controls the relative amount of L-thiamine and γ-aminobutyric acid, so as to
Selectively stress sleeping or loosen effect.
Specific embodiment
In the following, with reference to specific embodiment, the present invention is described further, it should be noted that is do not collided
Under the premise of, new embodiment can be formed between various embodiments described below or between each technical characteristic in any combination.
The present invention provides a kind of preparation method for loosening sleeping composition, includes the following steps：
1）Using solid-liquid ratio as 1:（5-10）PH=7 water for solvent, subcritical abstraction operation and fermentation operation are carried out to tealeaves,
Obtain the first crude extract；Fermenting microbe is one or more in galactococcus, streptococcus and lactobacillus；Wherein, subcritical abstraction
Process conditions be：Pressure is 0.6-0.8MPa, temperature is 45-55 DEG C；The process conditions of fermentation are：The inoculum concentration of strain is 1-
5%, 32 DEG C -37 DEG C of fermentation temperature；
2）Take 30 parts of spina date seed, 2.5-3.5 parts of Radix Glycyrrhizae, 8-10 parts of lily, 4-8 parts of Poria cocos, 4-8 parts of peach kernel, 4-8 parts of cape jasmine, with
Solid-liquid ratio is 1:（5-10）PH=7 water be solvent infusion extraction, obtain the second crude extract；
3）First crude extract and the second crude extract respectively at 80-90 DEG C are evaporated under reduced pressure, are spray-dried, with（1-10）:3
Ratio mixes, and obtains loosening sleeping composition；The technological parameter being wherein spray-dried is：100-120 DEG C of inlet air temperature, goes out wind-warm syndrome
70-80 DEG C of degree.
The preparation method extracts tealeaves by using fermentation and the matched mode of subcritical abstraction mode, can effectively improve
The extraction efficiency of L-thiamine and γ-aminobutyric acid, and reduce the precipitation of the ingredients such as the theophylline for being unfavorable for loosening, so as to make
User, which experiences, to be loosened, is pleasant；The preparation method passes through to improving《Synopsis Golden Chamber》In suanzaoren decoction formula, select medicine food same
The component in source substitutes the component that can not apply ordinary food and adds in lily, can make consumer more on the basis of loosening,
Heat-clearing is except dry etc., so as to play the role of improving sleep quality.
L-thiamine belongs to amides compound, is the primary amino acid in tealeaves, typically constitutes from 50 % of free amino acid
More than, the 1 %-2 % of content in stem tea, content can be more than 2 % in certain green tea.Leucine carrier can be passed through in 30min
Movement system reaches cerebral tissue, will not accumulate in vivo.
γ-aminobutyric acid also known as 4-Aminobutanoicacid (4-Aminobutanoic acid, 4-AB, abbreviation GABA) and γ-ammonia
Butyric acid is widely present in nature, by glutamic acid (Glutamic acid, Glu) through glutamate decarboxylase（Glutamate
Decarboxylase, EC4.1.1.15, abbreviation GAD or GDC）Catalysis, is the weight in mammalian central nervous system
The inhibitory neurotransmitter wanted.With important physiological function, the physiological activity reported, which has, to be adjusted blood pressure, promotes spiritual peace
Fixed, promotion brain blood flow promotes brain vigor, trophic nerve cell, increases growth hormone secretion, strong liver profit kidney, pre- preventing obesity, rush
Into alcohol metabolism（It sobers up）, improve the multiple efficacies such as climacteric syndrome.
Embodiment 1：
A kind of preparation method for loosening sleeping composition, includes the following steps：
1）Using the water of 0.7L pH=7 as solvent, subcritical abstraction operation is carried out to 100g tealeaves；The process conditions of subcritical abstraction
For：Pressure is 0.7MPa, temperature is 50 DEG C；
The fermenting microbe of 1wt% is added in the extracting solution that subcritical abstraction is obtained, in 36 DEG C of fermentations for 24 hours；First is obtained slightly to carry
Liquid；Fermenting microbe presses 1 by galactococcus, streptococcus and lactobacillus:1:8 weight ratio composition；
2）Take spina date seed 30g, 3 g of Radix Glycyrrhizae, 9 g of lily, 6 g of Poria cocos, 6 g of peach kernel, 6 g of cape jasmine, using the water of 0.42L pH=7 as
10h is extracted in solvent infusion, obtains the second crude extract；
3）First crude extract and the second crude extract are evaporated under reduced pressure and are spray-dried respectively at 85 DEG C, wherein the first crude extract
Weight is 7.8g after drying, and weight is 6.2g after the drying of the second crude extract；First crude extract dried object and the second crude extract dried object with
3:1 ratio mixing, obtains loosening sleeping composition；The technological parameter being wherein spray-dried is：110 DEG C of inlet air temperature, outlet air
75 DEG C of temperature.
Embodiment 2：
A kind of preparation method for loosening sleeping composition, includes the following steps：
1）Using the water of 0.7L pH=7 as solvent, 10g sodium glutamates are added in, to the strain of access 5% in 100g tealeaves, in 36 DEG C of hairs
Ferment 60h, obtains zymotic fluid；Wherein strain presses 1 by galactococcus, streptococcus and lactobacillus:1:8 weight ratio composition；
To zymotic fluid pressure is 0.7MPa, temperature is 50 DEG C of subcritical abstraction 10h, the first crude extract is obtained；
2）Spina date seed 30g, 3 g of Radix Glycyrrhizae, 9 g of lily, 6 g of Poria cocos, 6 g of peach kernel, 6 g of cape jasmine are taken, with the water of 0.42L pH=neutrality
10h is extracted for solvent infusion, obtains the second crude extract；
3）First crude extract and the second crude extract are evaporated under reduced pressure and are spray-dried respectively at 85 DEG C, wherein the first crude extract
Weight is 8.1g after drying, and weight is 6.3g after the drying of the second crude extract；First crude extract dried object and the second crude extract dried object with
1:3 ratio mixing, obtains loosening sleeping composition；The technological parameter being wherein spray-dried is：110 DEG C of inlet air temperature, outlet air
75 DEG C of temperature.
Embodiment 3：
A kind of preparation method for loosening sleeping composition, includes the following steps：
1）Using the water of 0.7L pH=7 as solvent, subcritical abstraction operation is carried out to 100g tealeaves；The process conditions of subcritical abstraction
For：Pressure is 0.6MPa, temperature is 55 DEG C；
The fermenting microbe of 1wt% is added in the extracting solution that subcritical abstraction is obtained, in 35 DEG C of fermentations for 24 hours；First is obtained slightly to carry
Liquid；Fermenting microbe is lactobacillus；
2）Spina date seed 30g, 3 g of Radix Glycyrrhizae, 9 g of lily, 6 g of Poria cocos, 6 g of peach kernel, 6 g of cape jasmine are taken, with the water of 0.42L pH=neutrality
10h is extracted for solvent infusion, obtains the second crude extract；
3）First crude extract and the second crude extract are evaporated under reduced pressure and are spray-dried respectively at 85 DEG C, wherein the first crude extract
Weight is 7.2g after drying, and weight is 6.2g after the drying of the second crude extract；First crude extract dried object and the second crude extract dried object with
2:1 ratio mixing, obtains loosening sleeping composition；The technological parameter being wherein spray-dried is：110 DEG C of inlet air temperature, outlet air
75 DEG C of temperature.
Embodiment 4：
A kind of preparation method for loosening sleeping composition, includes the following steps：
1）Using the water of 0.7L pH=7 as solvent, 10g sodium glutamates are added in, to accessing the lactobacillus of 5wt% in 100g tealeaves, in 35
DEG C fermentation 55h, obtain zymotic fluid；
To zymotic fluid pressure is 0.7MPa, temperature is 50 DEG C of subcritical abstraction 10h, the first crude extract is obtained；
2）Spina date seed 30g, 3 g of Radix Glycyrrhizae, 9 g of lily, 6 g of Poria cocos, 6 g of peach kernel, 6 g of cape jasmine are taken, with the water of 0.42L pH=neutrality
10h is extracted for solvent infusion, obtains the second crude extract；
3）First crude extract and the second crude extract are evaporated under reduced pressure and are spray-dried respectively at 85 DEG C, wherein the first crude extract
Weight is 8.0g after drying, and weight is 6.3g after the drying of the second crude extract；First crude extract dried object and the second crude extract dried object with
1:3 ratio mixing, obtains loosening sleeping composition；The technological parameter being wherein spray-dried is：110 DEG C of inlet air temperature, outlet air
75 DEG C of temperature.
Embodiment 5：
A kind of preparation for loosening sleeping composition, by the gained of 6g embodiments 1 to loosen sleeping composition, 2g maltodextrins and 2g micro-
Crystalline cellulose mixes, and tabletting is made.
Embodiment 6：
A kind of preparation for loosening sleeping composition, by the gained of 6g embodiments 2 to loosen sleeping composition, 2g maltodextrins and 2g micro-
Crystalline cellulose mixes, and tabletting is made.
Embodiment 7：
A kind of preparation for loosening sleeping composition, by the gained of 6g embodiments 3 to loosen sleeping composition, 2g maltodextrins and 2g micro-
Crystalline cellulose mixes, and tabletting is made.
Embodiment 8：
A kind of preparation for loosening sleeping composition, by the gained of 6g embodiments 4 to loosen sleeping composition, 2g maltodextrins and 2g micro-
Crystalline cellulose mixes, and tabletting is made.
Performance detection and effect assessment
1. analysis of effective component
To in embodiment 1-4, L-thiamine and γ-aminobutyric acid in the first crude extract are tested by area normalization method using HPLC
Content, the results are shown in table below：
Analysis of effective component in 1 first crude extract of table
| Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | |
| L-thiamine (g/L) | 10.2 | 6.5 | 9.6 | 6.2 |
| γ-aminobutyric acid (g/L) | 5.0 | 11.9 | 5.1 | 11.7 |
By table 1 it is found that fermenting again after first carrying out subcritical abstraction, the concentration of L-thiamine is relatively high, and first carries out
Subcritical abstraction is carried out after fermentation again, the content of γ-aminobutyric acid is relatively high.
2. relaxation effect detects
To the preparation that embodiment 5-8 is obtained, using double-blind study, 1 is pressed with maltodextrin and microcrystalline cellulose:1 weight ratio tabletting
Product after rest state 30min, uses wet electrode as reference substance, oral test-meal（Ag/AgCl）Monitoring test person's brain wave
Situation and the performance state of record volunteer.
5 groups of brain wave detection datas of embodiment show that α waves and β wave number amounts significantly increase, and the ratio of α waves and β waves is
0.9:1, apparent δ waves and θ waves are not monitored.Volunteer is visited in observation and inquiry, and volunteer, which experiences, to be loosened, is pleasant, illustrates to implement
The preparation of example 5, which has, significantly loosens effect；
6 groups of brain wave detection datas of embodiment show that the quantity of α waves, δ waves and θ waves significantly increases, and α waves/β waves are 1.4:1, β wave
It is suppressed.Volunteer is visited in observation and inquiry, and volunteer has sleepy sense, quickly enters sleep state, illustrates the preparation tool of embodiment 6
There is apparent function for assisting sleep.
7 groups of brain wave detection datas of embodiment show that α waves and β wave number amounts significantly increase, and the ratio of α waves and β waves is
0.8:1, apparent δ waves and θ waves are not monitored.Volunteer is visited in observation and inquiry, and volunteer, which experiences, to be loosened, is pleasant, illustrates to implement
The preparation of example 7, which has, significantly loosens effect；
8 groups of brain wave detection datas of embodiment show that the quantity of α waves, δ waves and θ waves significantly increases, and α waves/β waves are 1.5:1, β wave
It is suppressed.Volunteer is visited in observation and inquiry, and volunteer has sleepy sense, quickly enters sleep state, illustrates the preparation tool of embodiment 8
There is apparent function for assisting sleep.
The above embodiment is only the preferred embodiment of the present invention, it is impossible to the scope of protection of the invention is limited with this,
The variation and replacement for any unsubstantiality that those skilled in the art is done on the basis of the present invention belong to institute of the present invention
Claimed range.
Claims (7)
1. a kind of preparation method for loosening sleeping composition, which is characterized in that include the following steps：
1）Using solid-liquid ratio as 1:（5-10）PH=7 water for solvent, subcritical abstraction operation and fermentation operation are carried out to tealeaves,
Obtain the first crude extract；Fermenting microbe is one or more in galactococcus, streptococcus and lactobacillus；Wherein, subcritical abstraction
Process conditions be：Pressure is 0.6-0.8MPa, temperature is 45-55 DEG C；The process conditions of fermentation are：The inoculum concentration of strain is 1-
5%, 32 DEG C -37 DEG C of fermentation temperature；
2）Take 30 parts of spina date seed, 2.5-3.5 parts of Radix Glycyrrhizae, 8-10 parts of lily, 4-8 parts of Poria cocos, 4-8 parts of peach kernel, 4-8 parts of cape jasmine, with
Solid-liquid ratio is 1:（5-10）PH=7 water be solvent infusion extraction, obtain the second crude extract；
3）First crude extract and the second crude extract respectively at 80-90 DEG C are evaporated under reduced pressure, are spray-dried, with（1-10）: 3
Ratio mixing, obtain loosening sleeping composition；The technological parameter being wherein spray-dried is：100-120 DEG C of inlet air temperature, outlet air
70-80 DEG C of temperature.
2. preparation method as described in claim 1, which is characterized in that step 1）In, after first progress subcritical abstraction operation again
Carry out fermentation operation.
3. preparation method as described in claim 1, which is characterized in that step 1）In, it is carried out again after first being fermented subcritical
Extracting operation.
4. preparation method as claimed in claim 3, which is characterized in that step 1）In, the paddy ammonia of addition tealeaves weight 5-20wt%
Sour sodium ferments.
5. preparation method as described in claim 1, which is characterized in that step 1）In, strain is by galactococcus, streptococcus and newborn bar
Bacterium is pressed（1-2）:（1-2）:10 weight ratio composition.
It is 6. a kind of as what claim 1-4 any one of them preparation methods obtained loosens sleeping composition.
7. a kind of preparation for loosening sleeping composition, which is characterized in that be made including following components by weight：4-8 parts
Loosen sleeping composition, 1-3 portion maltodextrin and 1-3 parts of microcrystalline celluloses described in claim 6.
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|---|---|---|---|---|
| CN102488826A (en) * | 2011-12-14 | 2012-06-13 | 哈药集团中药二厂 | Method for preparing freeze-dried oral preparation of spina date seed decoction |
| CN105077477A (en) * | 2015-08-12 | 2015-11-25 | 北京晚安科技有限责任公司 | Sleeping-aid beverage |
| CN107197966A (en) * | 2017-05-18 | 2017-09-26 | 华南农业大学 | A kind of method of microorganism ferment making GABA tea |
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| CN102488826A (en) * | 2011-12-14 | 2012-06-13 | 哈药集团中药二厂 | Method for preparing freeze-dried oral preparation of spina date seed decoction |
| CN105077477A (en) * | 2015-08-12 | 2015-11-25 | 北京晚安科技有限责任公司 | Sleeping-aid beverage |
| CN107197966A (en) * | 2017-05-18 | 2017-09-26 | 华南农业大学 | A kind of method of microorganism ferment making GABA tea |
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