CN108132227A - The discrimination method and system of naproxen capsule agent - Google Patents
The discrimination method and system of naproxen capsule agent Download PDFInfo
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- CN108132227A CN108132227A CN201810204340.4A CN201810204340A CN108132227A CN 108132227 A CN108132227 A CN 108132227A CN 201810204340 A CN201810204340 A CN 201810204340A CN 108132227 A CN108132227 A CN 108132227A
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- CMWTZPSULFXXJA-UHFFFAOYSA-N Naproxen Natural products C1=C(C(C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-UHFFFAOYSA-N 0.000 title claims abstract description 166
- CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 title claims abstract description 166
- 229960002009 naproxen Drugs 0.000 title claims abstract description 166
- 239000002775 capsule Substances 0.000 title claims abstract description 141
- 239000003795 chemical substances by application Substances 0.000 title claims abstract description 138
- 238000012850 discrimination method Methods 0.000 title claims abstract description 24
- 238000010521 absorption reaction Methods 0.000 claims abstract description 76
- 238000001228 spectrum Methods 0.000 claims abstract description 37
- 239000000523 sample Substances 0.000 claims description 82
- 238000001328 terahertz time-domain spectroscopy Methods 0.000 claims description 22
- 230000003595 spectral effect Effects 0.000 claims description 20
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 12
- 239000013074 reference sample Substances 0.000 claims description 10
- BLXXJMDCKKHMKV-UHFFFAOYSA-N Nabumetone Chemical compound C1=C(CCC(C)=O)C=CC2=CC(OC)=CC=C21 BLXXJMDCKKHMKV-UHFFFAOYSA-N 0.000 claims description 9
- 229960004270 nabumetone Drugs 0.000 claims description 9
- 238000005259 measurement Methods 0.000 claims description 7
- 229910052757 nitrogen Inorganic materials 0.000 claims description 6
- 230000009466 transformation Effects 0.000 claims description 5
- 230000005540 biological transmission Effects 0.000 claims description 3
- 238000004364 calculation method Methods 0.000 claims description 3
- 238000009738 saturating Methods 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 19
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 description 8
- 239000003814 drug Substances 0.000 description 8
- 238000001514 detection method Methods 0.000 description 7
- 230000008569 process Effects 0.000 description 6
- 229940079593 drug Drugs 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 5
- 238000000862 absorption spectrum Methods 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 230000003111 delayed effect Effects 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 229910001218 Gallium arsenide Inorganic materials 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 206010002556 Ankylosing Spondylitis Diseases 0.000 description 1
- 201000005569 Gout Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000000571 coke Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 238000000407 epitaxy Methods 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000002329 infrared spectrum Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000006317 isomerization reaction Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000004570 mortar (masonry) Substances 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000010287 polarization Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- 238000004451 qualitative analysis Methods 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
- G01N21/3581—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using far infrared light; using Terahertz radiation
- G01N21/3586—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using far infrared light; using Terahertz radiation by Terahertz time domain spectroscopy [THz-TDS]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
- G01N21/88—Investigating the presence of flaws or contamination
- G01N21/95—Investigating the presence of flaws or contamination characterised by the material or shape of the object to be examined
- G01N21/9508—Capsules; Tablets
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/286—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q involving mechanical work, e.g. chopping, disintegrating, compacting, homogenising
- G01N2001/2866—Grinding or homogeneising
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- Spectroscopy & Molecular Physics (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Physics & Mathematics (AREA)
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- Life Sciences & Earth Sciences (AREA)
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- Investigating Or Analysing Materials By Optical Means (AREA)
Abstract
The present invention relates to a kind of discrimination method of naproxen capsule agent, this method includes：Acquire the terahertz time-domain waveform of naproxen capsule agent sample to be measured；The Terahertz frequency domain spectra of naproxen capsule agent sample to be measured is obtained according to terahertz time-domain waveform；The characteristic absorption peak of naproxen capsule agent sample to be measured is extracted according to Terahertz frequency domain spectra；Differentiate the type of naproxen capsule agent to be measured according to characteristic absorption peak.Above-mentioned naproxen capsule agent discrimination method, it is easy to operate quick, lossless to naproxen capsule agent and more efficient.
Description
Technical field
The present invention relates to drugs to differentiate field, more particularly to a kind of discrimination method and system of naproxen capsule agent.
Background technology
Naproxen (Naproxen) is anti inflammation and heat resolution antalgesic, is widely used in and alleviates rheumatism and rheumatoid arthritis, bone
Whole body fever caused by arthritis, ankylosing spondylitis, gout etc., part redness and pain symptom.Since different vendor produces
Naproxen capsule agent had differences in the addition of adjunct ingredient and additive amount, production technology, polymorph in pharmaceuticals etc., cause
There are larger difference on principal component content, efficacy of drugs and drug price, therefore, for the Nabumetone raw rubber of different vendor's production
The discriminating of wafer is distinguished particularly important.
Traditional naproxen qualitative analysis is mainly using mid-infrared light spectral technology, but in middle infrared spectrum reflection substance respectively
The vibration of functional group is difficult to chiral photo-isomerisation molecule to differentiate differentiation, and in the naproxen capsule agent of different vendor's production
Infrared spectrogram difference is small, so that it cannot effectively differentiating the naproxen capsule agent of different vendor's production.
Invention content
Based on this, it is necessary to provide a kind of discrimination method and system of naproxen capsule agent, can effectively differentiate Nabumetone
The type of raw rubber wafer.
A kind of discrimination method of naproxen capsule agent, including：
Acquire the terahertz time-domain waveform of naproxen capsule agent sample to be measured；
The Terahertz frequency domain spectra of the naproxen capsule agent sample to be measured is obtained according to the terahertz time-domain waveform；
The characteristic absorption peak of the naproxen capsule agent sample to be measured is extracted according to the Terahertz frequency domain spectra；
Differentiate the type of the naproxen capsule agent to be measured according to the characteristic absorption peak.
In one of the embodiments, the step of terahertz time-domain spectrum of acquisition naproxen capsule agent sample to be measured it
Before, it further includes：
Prepare the naproxen capsule agent sample to be measured.
The terahertz time-domain waveform is obtained by terahertz time-domain spectroscopy instrument device measurement in one of the embodiments,
The step of terahertz time-domain waveform of the acquisition naproxen capsule agent sample to be measured, includes：
Nitrogen is delivered in the sample bin of the terahertz time-domain spectroscopy instrument device；
Detect the relative humidity of the sample bin；
Judge whether the relative humidity is less than default relative humidity, if so, by the naproxen capsule agent sample to be measured
Product are placed in the sample bin；
The naproxen capsule agent sample to be measured is irradiated using terahertz light；
Acquire the terahertz time-domain waveform after the terahertz light transmission naproxen capsule agent sample to be measured.
It is described in one of the embodiments, that the naproxen capsule agent to be measured is obtained according to the terahertz time-domain waveform
The step of Terahertz frequency domain spectra of sample, includes：
The terahertz time-domain waveform of the naproxen capsule agent sample to be measured is subjected to Fourier transformation, is obtained accordingly too
Hertz frequency domain spectra.
The feature of the naproxen capsule agent sample is extracted according to the Terahertz frequency domain spectra in one of the embodiments,
The step of absorption peak, includes：
The terahertz time-domain waveform of reference sample is acquired, and obtains referring to frequency domain spectra accordingly；
Using described with reference to frequency domain spectra, and based on the Terahertz of the Lambert law acquisition naproxen capsule agent sample to be measured
The relative absorption coefficient of frequency domain spectral intensity；
The maximum value in the relative absorption coefficient is extracted, the characteristic absorption as the naproxen capsule agent sample to be measured
Peak.
The terahertz that the naproxen capsule agent sample to be measured is obtained based on Lambert law in one of the embodiments,
Hereby the calculation formula of the relative absorption coefficient of frequency domain spectral intensity is：
Wherein, ω is Terahertz frequency, and α (ω) is the relative absorption coefficient,For the Nabumetone raw rubber to be measured
The Terahertz frequency domain spectral intensity of wafer sample,To refer to frequency domain spectral intensity.
The kind for differentiating the naproxen capsule agent to be measured according to the characteristic absorption peak in one of the embodiments,
The step of class, including：.
Obtain the characteristic absorption peak of naproxen standard items；
Compare the characteristic absorption peak of the naproxen standard items and the naproxen capsule agent to be measured, and obtain fiducial value；
Differentiate the type of the naproxen capsule agent to be measured according to the fiducial value.
The naproxen capsule agent to be measured includes the first naproxen capsule agent and the second Nabumetone in one of the embodiments,
Raw rubber wafer, and the characteristic absorption peak of the first naproxen capsule agent is more than the characteristic absorption peak of the naproxen standard items,
The characteristic absorption peak of the second naproxen capsule agent is less than the characteristic absorption peak of the naproxen standard items.
A kind of identification system of naproxen capsule agent, including：
Terahertz time-domain spectroscopy instrument device, for obtaining the terahertz time-domain waveform of naproxen capsule agent sample to be measured；
Electronic equipment, for performing the discrimination method of above-mentioned naproxen capsule agent.
The terahertz time-domain spectroscopy instrument device includes transmission-type terahertz time-domain spectroscopy instrument in one of the embodiments,
Device or reflective terahertz time-domain spectroscopy instrument device.
The discrimination method of above-mentioned naproxen capsule agent by acquiring the terahertz time-domain waveform of naproxen capsule agent, and obtains
The characteristic absorption peak in corresponding Terahertz frequency domain spectra and extraction Terahertz frequency domain spectra is taken, using characteristic absorption peak to Nabumetone to be measured
The type of raw rubber wafer is differentiated.This method is easy to operate quick, lossless to naproxen capsule agent and can effectively differentiate naphthalene
The type of general raw rubber wafer.
Description of the drawings
Fig. 1 is the naproxen capsule agent discrimination method flow chart of an embodiment；
Fig. 2 is the naproxen capsule agent discrimination method flow chart of another embodiment；
Fig. 3 is a kind of flow chart of implementation method of step S100 in Fig. 1；
Fig. 4 is a kind of flow chart of implementation method of step S300 in Fig. 1；
Fig. 5 is a kind of flow chart of implementation method of step S400 in Fig. 1；
Fig. 6 is the Terahertz absorption spectra schematic diagram of the naproxen capsule agent of an embodiment；
Fig. 7 is the identification system schematic diagram of the naproxen capsule agent of an embodiment.
Specific embodiment
In order to make the purpose , technical scheme and advantage of the present invention be clearer, with reference to the accompanying drawings and embodiments, it is right
The present invention is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, and
It is not used in the restriction present invention.On the contrary, the purpose that these embodiments are provided be make to disclose present disclosure it is more thorough complete
Face.
Fig. 1 is the naproxen capsule agent discrimination method flow chart of an embodiment, and this method includes the following contents.
Step S100：Acquire the terahertz time-domain waveform of naproxen capsule agent sample to be measured.Terahertz time-domain waveform reflects
Be absorbing state of the different time sections naproxen capsule agent sample to be measured to THz wave.
Step S200：The Terahertz frequency domain spectra of naproxen capsule agent sample to be measured is obtained according to terahertz time-domain waveform.Too
The reflection of hertz frequency domain spectra be in the unit interval sample to the absorbing state of different-waveband THz wave.
Step S300：The characteristic absorption peak of naproxen capsule agent sample to be measured is extracted according to Terahertz frequency domain spectra.Naproxen
Many Common drugs such as capsule in Terahertz frequency domain spectra there are apparent characteristic absorption, and different naproxen capsule agent samples
Characteristic absorption peak it is different.Therefore, using naproxen capsule agent sample terahertz wave band characteristic absorption peak, to naproxen
The structure and its type of capsule sample are analyzed and are differentiated.
Step S400：Differentiate the type of naproxen capsule agent to be measured according to characteristic absorption peak.Specifically, naproxen capsule agent
Sample in terahertz wave band existing characteristics absorption peak, according to the peak value size of characteristic absorption peak or according to characteristic absorption peak near
The slope size of absorption curve can realize the type discriminating to naproxen capsule agent to be measured.
In the present embodiment, THz wave is commonly referred to as 0.1THz to the electromagnetic wave of 10THz frequency ranges, between far infrared and micro-
Between wave, the phonon of the low-frequency vibration of the intramolecular of many biomolecule, intermolecular weak interaction (such as hydrogen bond) and lattice
Vibration mode etc. is in terahertz wave band.Therefore, (refer in the terahertz wave band absorption spectra that has different characteristics using substance
Line is composed) Qualitive test analysis is carried out to it.In addition, THz wave has photon energy low, in detection process, will not generate harmful
Photoionization the advantages that.Terahertz light spectral technology is raw on basis as near-infrared and the useful supplement of mid-infrared light spectral technology
It is all rising in terms of object science, medicine and material science, have especially in terms of Western medicine qualitative detection boundless
Application prospect.
The discrimination method of above-mentioned naproxen capsule agent by acquiring the terahertz time-domain waveform of naproxen capsule agent, and obtains
The characteristic absorption peak in corresponding Terahertz frequency domain spectra and extraction Terahertz frequency domain spectra is taken, using characteristic absorption peak to Nabumetone to be measured
The type of raw rubber wafer is differentiated.This method is easy to operate quick, lossless to naproxen capsule agent and can effectively differentiate naphthalene
The type of general raw rubber wafer.
In one of the embodiments, before step S100, further include：
Step S100'：Prepare naproxen capsule agent sample to be measured.
Specifically, naproxen capsule agent to be measured is ground into and with the mesh screen mistake of 200 mesh by fine powdered using agate mortar
Sieve；The powder 0.25g after sieving is weighed, is suppressed using oil-pressure jack, and 20MPa pressure is kept to suppress 2 minutes.By upper
Processing procedure is stated, finally obtains the naproxen capsule agent sample of clean smooth thin rounded flakes, thickness is about 2.61mm, diameter
About 13mm.
Terahertz time-domain waveform is obtained by terahertz time-domain spectroscopy instrument device measurement in one of the embodiments, step
The realization method of S100 specifically includes：
Step S110：Nitrogen is delivered in the sample bin of terahertz time-domain spectroscopy instrument device.
Specifically, temperature of the sample bin before nitrogen is inputted be generally 23 DEG C, relative humidity be generally 48%.To prevent
The interference of steam signal in detection process need to lead to the high pure nitrogen that purity is 99.9%, to reduce the phase of sample bin to sample bin
To humidity.Optionally, the flow set of nitrogen input is 15L/min.
Step S120：Detect the relative humidity of sample bin.
Specifically, humidity sensor is equipped in sample bin.Humidity sensor can directly acquire relatively wet in sample bin
Analog signals are spent, and are input to terahertz time-domain spectroscopy instrument device, obtain rh value.
Step S130：Judge whether relative humidity is less than default relative humidity, if so, performing step S240；Otherwise it returns
Return step S120.Relative humidity is excessive, to dehumidify to sample bin, prevents the interference of steam signal.This step can perform
Repeatedly, to ensure the accuracy of Humidity Detection result.
Specifically, default relative humidity is set as 1%.
Step S140：Naproxen capsule agent sample to be measured is placed in sample bin.
Specifically, the naproxen capsule agent sample prepared by step S100' is placed in tableting clamp, then fixture is put into
On the specimen holder of the sample bin of terahertz time-domain spectroscopy instrument.
Step S150：Naproxen capsule agent sample to be measured is irradiated using terahertz light.
Specifically, terahertz time-domain spectroscopy instrument is equipped with femto-second laser, emits terahertz light arteries and veins using femto-second laser
Naproxen capsule agent sample to be measured is irradiated in punching.
Step S160：Acquire the terahertz time-domain waveform after terahertz light transmission naproxen capsule agent sample to be measured.
Specifically, it treats steam blackout, after signal stabilization, obtains the time domain waveform of naproxen capsule agent sample.
In the present embodiment, it carries out needing through tera-hertz spectra system software program before naproxen capsule agent sample detection
Panel measures parameter setting.Measurement parameter includes the scan frequency of spectral resolution and terahertz pulse.For example, spectral resolution
It is set as 0.94cm-1；Scan frequency is set as 900/min (i.e. continuous 900 acquisition average value used times about 1min of scanning).By this
Measurement parameter is set, and data processing can be made simple, reproducible, measurement result is accurate.
The realization method of step S200 includes in one of the embodiments,：
The terahertz time-domain waveform of naproxen capsule agent sample to be measured is subjected to Fourier transformation, obtains corresponding Terahertz
Frequency domain spectra.
Specifically, Fourier transformation process is represented by：
Wherein, Es(t) the terahertz time-domain waveform signal of naproxen capsule agent sample to be measured is represented；Represent to be measured
The Terahertz frequency domain spectral intensity of naproxen capsule agent sample；As(ω) represents the Terahertz frequency domain of naproxen capsule agent sample to be measured
Spectral amplitude；φs(ω) represents the Terahertz frequency domain spectra phase of naproxen capsule agent sample to be measured；ω represents Terahertz frequency.
The realization method of step S300 includes in one of the embodiments,：
Step S310：The terahertz time-domain waveform of reference sample is acquired, and obtains referring to frequency domain spectra accordingly.
Specifically, Fourier transformation can be carried out by the terahertz time-domain waveform of reference sample with reference to frequency domain spectra to obtain, specifically
Conversion process is represented by：
Wherein, Er(t) the terahertz time-domain waveform signal of reference sample is represented；Represent the Terahertz of reference sample
Frequency domain spectral intensity；Ar(ω) represents the Terahertz frequency domain spectral amplitude of reference sample；φr(ω) represents the Terahertz frequency of reference sample
Compose phase in domain；ω represents Terahertz frequency.
Optionally, reference sample is air.The gatherer process of the terahertz time-domain waveform of reference sample and naproxen to be measured
The gatherer process of capsule is identical, does not just repeat here.
Step S320：Using with reference to frequency domain spectra, and obtain based on Lambert law the terahertz of naproxen capsule agent sample to be measured
The hereby relative absorption coefficient of frequency domain spectral intensity.
Specifically, the calculation formula of relative absorption coefficient represents as follows：
Wherein, ω represents Terahertz frequency；α (ω) represents relative absorption coefficient；Represent naproxen capsule agent to be measured
The Terahertz frequency domain spectral intensity of sample；It represents with reference to frequency domain spectral intensity.
Step S330：The maximum value in the relative absorption coefficient is extracted, as the naproxen capsule agent sample to be measured
Characteristic absorption peak.
Specifically, the characteristic absorption peak of naproxen capsule agent sample to be measured is located at 1.21THz and 1.67THz.
The realization method of step S400 includes in one of the embodiments,：.
Step S410：Obtain the characteristic absorption peak of naproxen standard items.Standard items are a kind of measurement standard, are used as drug side
Face is then the standard content in assay.
Specifically, the obtaining step of the characteristic absorption peak of naproxen standard items is identical with naproxen capsule agent to be measured, here
Just do not repeat.
Step S420：Compare the characteristic absorption peak of the naproxen standard items and the naproxen capsule agent to be measured, and obtain
Take fiducial value.Although naproxen standard items are identical with the position of the characteristic absorption peak of naproxen capsule agent to be measured, different treats
The of different sizes of the characteristic absorption peak of resistance to general raw rubber wafer is surveyed, the size of their characteristic absorption peaks with naproxen standard items is not yet
Together.
Specifically, it is obtained by comparing the size of naproxen standard items and the characteristic absorption peak of naproxen capsule agent to be measured
Fiducial value.
Step S430：Differentiate the type of the naproxen capsule agent to be measured according to fiducial value.
Specifically, naproxen capsule agent to be measured includes the first naproxen capsule agent and the second naproxen capsule agent, and first
The characteristic absorption peak of naproxen capsule agent is more than the characteristic absorption peak of naproxen standard items, and the feature of the second naproxen capsule agent is inhaled
Receive the characteristic absorption peak that peak is less than naproxen standard items.The fiducial value of this step is naproxen capsule agent to be measured and naproxen standard
The size of the characteristic absorption peak of product compares.When fiducial value is more than zero, naproxen capsule agent to be measured is the first naproxen capsule agent；
When fiducial value is less than zero, naproxen capsule agent to be measured is the second naproxen capsule agent.
Further, as shown in fig. 6, the first naproxen capsule agent is：The people's pharmacy of naproxen nation；Second naproxen capsule
Agent is：(trade name is the pharmacy of naproxen grace China：Suitable Luo Te).L0 is the Terahertz absorption curve of naproxen standard items；L1
Terahertz absorption curve for the first naproxen capsule agent (people's pharmacy of naproxen nation)；L2 is the second naproxen capsule agent (naphthalene
Pu Shengenhua pharmacy) Terahertz absorption curve.Wherein, the characteristic absorption peak of L0 is most strong, and two kinds of naproxen capsule agent are too
The characteristic absorption peak intensity of hertz absorption curve (L1 and L2) is different (because the percentage of naproxen contains in different naproxen capsule agent
Amount is different), and the characteristic absorption peak of L1 is higher than the characteristic absorption peak of L0, the characteristic absorption peak of L0 is higher than the characteristic absorption peak of L2.
Wherein, the slope of L2 and naphthalene L0 are basically identical, and the slope of L1 is larger.It therefore can be according to the characteristic absorption of Terahertz absorption curve
The height at peak and the slope difference of absorption curve distinguish different types of naproxen capsule agent.
Fig. 7 is the identification system of the kind naproxen capsule agent of an embodiment, which includes：Terahertz time-domain spectroscopy
Instrument device 100, for obtaining the terahertz time-domain waveform of naproxen capsule agent sample to be measured；Electronic equipment 200, for execution
The discrimination method of naproxen capsule agent stated.Wherein, electronic equipment 200 include computer and tera-hertz spectra (including Time Domain Spectrum,
Frequency domain spectra, absorption spectra and refractive index) processing equipment.
Terahertz time-domain spectroscopy instrument device 100 includes transmission-type terahertz time-domain spectroscopy instrument in one of the embodiments,
Device or reflective terahertz time-domain spectroscopy instrument device.
Specifically, referring to Fig. 7, when terahertz time-domain spectroscopy instrument device 100 is transmission-type terahertz time-domain spectroscopy instrument device
When, including：It femto-second laser 110, beam splitting chip 120, sample bin 130, delayed time system 140 and is set in sample bin 130
Terahertz emission end 131, paraboloidal mirror 132, objective table 133, Terahertz receiving terminal 134.Wherein, femto-second laser 100 is sent out
Femto-second laser pulse be divided into orthogonal two beam in polarization direction after beam splitting chip 120, wherein the light intensity penetrated is stronger
It is a branch of as pump light, and that Shu Zuowei detection light that the light intensity that reflects is weaker.
On the one hand, Terahertz receiving terminal 134 is converged at after detection light elapsed time delay system 140；On the other hand, it pumps
Light is incident in terahertz emission end 131, and terahertz emission end 131 is equipped with transmitting crystal GaAs (the GaAs light of low-temperature epitaxy
Lead antenna) on, it is excited by optical rectification effect and generates terahertz pulse, the terahertz pulse launched is gathered by paraboloidal mirror 132
On naproxen capsule agent sample to be measured on coke to objective table 133, terahertz pulse is loaded with naproxen capsule agent after penetrating sample
Sample message, and focused in Terahertz receiving terminal 134 by another axis paraboloidal mirror.Terahertz receiving terminal 134 is in two-way terahertz
Faint current signal is generated under the driving of hereby pulse.
Electronic equipment 200 connects Terahertz receiving terminal 134 and delayed time system 140.On the one hand, electronic equipment 200, which receives, comes
From the current signal of Terahertz receiving terminal 134, and Terahertz absorption spectra is obtained after carrying out respective handling.On the other hand, electronics is set
The delay time of standby 200 control delayed time system 140, so as to the current signal that Terahertz receiving terminal 134 is controlled to generate.
The discrimination method and system of above-mentioned naproxen capsule agent, by the terahertz time-domain wave for acquiring naproxen capsule agent
Shape, and the characteristic absorption peak in corresponding Terahertz frequency domain spectra and extraction Terahertz frequency domain spectra is obtained, utilize characteristic absorption peak pair
The type of naproxen capsule agent to be measured is differentiated.This method is easy to operate quick, lossless to naproxen capsule agent and can have
Effect differentiates the type of naproxen capsule agent.
Each technical characteristic of embodiment described above can be combined arbitrarily, to make description succinct, not to above-mentioned reality
It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, it is all considered to be the range of this specification record.
Embodiment described above only expresses the several embodiments of the present invention, and description is more specific and detailed, but simultaneously
It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that those of ordinary skill in the art are come
It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to the protection of the present invention
Range.Therefore, the protection domain of patent of the present invention should be determined by the appended claims.
Claims (10)
1. a kind of discrimination method of naproxen capsule agent, which is characterized in that including：
Acquire the terahertz time-domain waveform of naproxen capsule agent sample to be measured；
The Terahertz frequency domain spectra of the naproxen capsule agent sample to be measured is obtained according to the terahertz time-domain waveform；
The characteristic absorption peak of the naproxen capsule agent sample to be measured is extracted according to the Terahertz frequency domain spectra；
Differentiate the type of the naproxen capsule agent to be measured according to the characteristic absorption peak.
2. discrimination method according to claim 1, which is characterized in that the acquisition naproxen capsule agent sample to be measured is too
Before the step of hertz Time Domain Spectrum, further include：
Prepare the naproxen capsule agent sample to be measured.
3. discrimination method according to claim 1, which is characterized in that the terahertz time-domain waveform is by terahertz time-domain light
The step of spectrometer apparatus measurement obtains, the terahertz time-domain waveform of the acquisition naproxen capsule agent sample to be measured includes：
Nitrogen is delivered in the sample bin of the terahertz time-domain spectroscopy instrument device；
Detect the relative humidity of the sample bin；
Judge whether the relative humidity is less than default relative humidity, if so, the naproxen capsule agent sample to be measured is put
Enter in the sample bin；
The naproxen capsule agent sample to be measured is irradiated using terahertz light；
Acquire the terahertz time-domain waveform after the terahertz light transmission naproxen capsule agent sample to be measured.
4. discrimination method according to claim 3, which is characterized in that described that institute is obtained according to the terahertz time-domain waveform
The step of Terahertz frequency domain spectra for stating naproxen capsule agent sample to be measured, includes：
The terahertz time-domain waveform of the naproxen capsule agent sample to be measured is subjected to Fourier transformation, obtains corresponding Terahertz
Frequency domain spectra.
5. discrimination method according to claim 1, which is characterized in that the Nabumetone is extracted according to the Terahertz frequency domain spectra
The step of characteristic absorption peak of raw rubber wafer sample, includes：
The terahertz time-domain waveform of reference sample is acquired, and obtains referring to frequency domain spectra accordingly；
Using described with reference to frequency domain spectra, and based on the Terahertz frequency domain of the Lambert law acquisition naproxen capsule agent sample to be measured
The relative absorption coefficient of spectral intensity；
The maximum value in the relative absorption coefficient is extracted, the characteristic absorption peak as the naproxen capsule agent sample to be measured.
6. discrimination method according to claim 5, which is characterized in that described that the Nabumetone to be measured is obtained based on Lambert law
The calculation formula of the relative absorption coefficient of the Terahertz frequency domain spectral intensity of raw rubber wafer sample is：
Wherein, ω is Terahertz frequency, and α (ω) is the relative absorption coefficient,For the naproxen capsule agent to be measured
The Terahertz frequency domain spectral intensity of sample,To refer to frequency domain spectral intensity.
7. discrimination method according to claim 1, which is characterized in that described to be treated according to differentiating the characteristic absorption peak
The step of surveying the type of naproxen capsule agent, including：.
Obtain the characteristic absorption peak of naproxen standard items；
Compare the characteristic absorption peak of the naproxen standard items and the naproxen capsule agent to be measured, and obtain fiducial value；
Differentiate the type of the naproxen capsule agent to be measured according to the fiducial value.
8. discrimination method according to claim 7, which is characterized in that the naproxen capsule agent to be measured includes the first Nabumetone
Raw rubber wafer and the second naproxen capsule agent, and the characteristic absorption peak of the first naproxen capsule agent is more than the naproxen mark
The characteristic absorption peak of quasi- product, the characteristic absorption peak of the second naproxen capsule agent are less than the feature suction of the naproxen standard items
Receive peak.
9. a kind of identification system of naproxen capsule agent, which is characterized in that including：
Terahertz time-domain spectroscopy instrument device, for obtaining the terahertz time-domain waveform of naproxen capsule agent sample to be measured；
Electronic equipment, for the discrimination method of the naproxen capsule agent described in any claim in perform claim requirement 1 to 8.
10. identification system according to claim 9, which is characterized in that the terahertz time-domain spectroscopy instrument device includes saturating
Penetrate formula terahertz time-domain spectroscopy instrument device or reflective terahertz time-domain spectroscopy instrument device.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810204340.4A CN108132227A (en) | 2018-03-13 | 2018-03-13 | The discrimination method and system of naproxen capsule agent |
| PCT/CN2019/074051 WO2019174427A1 (en) | 2018-03-13 | 2019-01-31 | Method and system for identifying naproxen capsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201810204340.4A CN108132227A (en) | 2018-03-13 | 2018-03-13 | The discrimination method and system of naproxen capsule agent |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019174427A1 (en) * | 2018-03-13 | 2019-09-19 | 深圳市太赫兹科技创新研究院 | Method and system for identifying naproxen capsule |
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| CN108132227A (en) * | 2018-03-13 | 2018-06-08 | 深圳市太赫兹科技创新研究院 | The discrimination method and system of naproxen capsule agent |
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| CN103822884A (en) * | 2013-12-19 | 2014-05-28 | 中国矿业大学 | Classified identification method for tea based on terahertz time-domain spectroscopy |
| CN104266993A (en) * | 2014-08-28 | 2015-01-07 | 北京环境特性研究所 | Article characteristic extraction method and device based on terahertz frequency band |
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| WO2019174427A1 (en) * | 2018-03-13 | 2019-09-19 | 深圳市太赫兹科技创新研究院 | Method and system for identifying naproxen capsule |
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| WO2019174427A1 (en) | 2019-09-19 |
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