CN108129555B - Design of a peptide that specifically binds to the immune protein of Pseudomonas aeruginosa type VI secretion system and validation of its antibacterial activity - Google Patents
Design of a peptide that specifically binds to the immune protein of Pseudomonas aeruginosa type VI secretion system and validation of its antibacterial activity Download PDFInfo
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- CN108129555B CN108129555B CN201710811434.3A CN201710811434A CN108129555B CN 108129555 B CN108129555 B CN 108129555B CN 201710811434 A CN201710811434 A CN 201710811434A CN 108129555 B CN108129555 B CN 108129555B
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Abstract
本发明公开了一类特异性结合铜绿假单胞菌六型分泌系统免疫蛋白的多肽的设计及其抗菌活性的验证。本发明首先保护一种多肽,为序列表的序列3所示的多肽或序列表的序列4所示的多肽。编码所述多肽的基因也属于本发明的保护范围。本发明还保护所述多肽的应用:结合细菌Ⅵ型分泌系统中的免疫蛋白;富集细菌Ⅵ型分泌系统中的免疫蛋白;检测细菌Ⅵ型分泌系统中的免疫蛋白。本发明提供的功能短肽可以与效应蛋白竞争性结合免疫蛋白,从而破坏TplE‑TplEi互作,从而促使效应蛋白裂解细菌自身的的细胞膜引发细菌自我死亡,这将是一个最有力的以T6SS效应蛋白为靶点的新型抗菌策略,为临床耐药菌株的治疗提供新方向。The invention discloses the design of a class of polypeptides that specifically binds to the immune protein of Pseudomonas aeruginosa type VI secretion system and the verification of its antibacterial activity. The present invention first protects a polypeptide, which is the polypeptide shown in Sequence 3 of the Sequence Listing or the polypeptide shown in Sequence 4 of the Sequence Listing. The gene encoding the polypeptide also belongs to the protection scope of the present invention. The invention also protects the application of the polypeptide: combining immune proteins in bacterial type VI secretion system; enriching immune proteins in bacterial type VI secretion system; detecting immune proteins in bacterial type VI secretion system. The functional short peptide provided by the present invention can compete with the effector protein to bind the immune protein, thereby destroying the TplE-TplEi interaction, thereby prompting the effector protein to lyse the cell membrane of the bacteria and trigger the self-death of the bacteria, which will be the most powerful T6SS effect. Protein-targeted novel antibacterial strategies provide new directions for the treatment of clinical drug-resistant strains.
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CN109517046B (en) * | 2018-11-28 | 2021-09-14 | 福建师范大学 | Antibacterial polypeptide based on outer membrane protein generation mechanism and application thereof |
CN109825464B (en) * | 2019-01-17 | 2021-06-15 | 浙江海洋大学 | An Attenuated Fish Vaccine for Pseudomonas Pseudomonas Ayusan Knockout of T6SS-1 Gene Cluster |
CN114540377B (en) * | 2022-02-17 | 2023-11-17 | 中国科学院水生生物研究所 | Effector molecules of Flavobacterium columnar type VI secretion system and their immune proteins and their applications |
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CN101897951A (en) * | 2009-05-31 | 2010-12-01 | 中国人民解放军第二军医大学 | Anti-inflammatory effect, implementation method and application of a novel anti-inflammatory molecule DRP |
US9580509B2 (en) * | 2011-11-07 | 2017-02-28 | Medimmune, Llc | Multispecific and multivalent binding proteins and uses thereof |
CN106814124A (en) * | 2015-11-30 | 2017-06-09 | 上海交通大学 | A kind of system and method for glycoprotein solid phase enrichment coupling Mass Spectrometer Method |
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