CN108113696A - Detector, depth survey detector cells and its depth of interaction computational methods - Google Patents
Detector, depth survey detector cells and its depth of interaction computational methods Download PDFInfo
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Abstract
The present invention is suitable for field of medical device, disclose depth survey detector cells, the depth of interaction computational methods and detector of depth survey detector cells, wherein, depth survey detector cells include two and are spaced the scintillation crystal being arranged side by side and two photodetectors for being respectively arranged on two scintillation crystal one end, gap between two scintillation crystals is included close to the first layer space of photodetector, second away from photodetector is layered space and positioned at first, the 3rd layering space between two layering spaces, the first reflectance coating is filled in first layer space, optical coupled body is filled in second layering space, air is filled in 3rd layering space.The present invention to scintillation crystal in the case of need not carry out complex process, it is read by single-ended photodetector, realize the measurement of continuous depth of interaction, the realization difficulty and cost of detector depth of interaction measurement are reduced, and its depth resolution is high, temporal resolution is high, uniformity is good.
Description
Technical field
The present invention relates to field of medical device more particularly to depth survey detector cells, the depth survey detector lists
The depth of interaction computational methods of member and the detector with the depth survey detector cells.
Background technology
PET (Positron Emission Tomography, positron emission tomography) is a kind of advanced core doctor
Learn Image-forming instrument.Detector is the core component of PET system, mainly brilliant by flicker for detecting the position of gamma ray generation
Body and photodetector composition.Silicon photomultiplier (SiPM) array is a kind of photodetector for being usually used in PET system.PET
The scintillation crystal of detector is usually made of the small long crystal in many sections, since gamma ray is had an effect in scintillation crystal
The uncertainty of depth (depth of interaction, DOI), PET system resolution ratio can degenerate at deviation central region;
Same effect is present in the axial direction of detector, and for oblique line of response, the axial direction of detector is longer, PET spatial resolutions
Degree of susceptibility can be more serious.In clinical panorama PET scanner, big, the axial visual field of diameter of detector rings is long, axial to differentiate
Rate is influenced very serious by the uncertain effect of depth of interaction, uses the PET system of the non-depth survey detector of tradition
It can not realize high-resolution.And the uncertainty of depth of interaction will also result in the inhomogeneities of PET resolution ratio.
In recent years, with the development of scintillation crystal technique and silicon photomultiplier technology and the reduction of cost, to research and develop valency
The moderate panorama PET instruments of lattice (the clinical PET of the axial visual field about 200cm) create advantage.Due to traditional clinical PET
Detector does not possess depth of interaction measurement capability, therefore, technical staff can only obtain gamma ray by detector and be happened at
In which crystal, and it can not know and be happened at which of crystal depth, therefore be difficult to realize and obtain full visual field high-resolution
The clinical panorama PET system of rate.
To solve the problems, such as above-mentioned traditional technology, the prior art proposes a kind of pet detector with depth survey ability,
Embodiments thereof is:Netted cutting process is carried out to scintillation crystal predetermined depth using laser, scintillation crystal item occurs more
A different layer, then the top layer of two scintillation crystals is subjected to coupling composition detector cells by optical cement, rest part is adopted
Isolated with enhanced optical reflection film (ESR), gather the output energy of each scintillation crystal respectively by two photodetectors, led to
The information that different layers are calculated in energy ratio is crossed, so as to obtain depth of interaction information.The embodiment needs brilliant to flicker
Body strip adoption laser sub-surface cutting technique is handled so that crystal section generates netted layering, and does not cut off, shortcoming
It is that scintillation crystal cutting technique difficulty is big, of high cost, time-consuming, and uniformity is difficult to control, and depth of interaction information does not connect
It is continuous.
The content of the invention
First of the present invention is designed to provide a kind of depth survey detector cells, aims to solve the problem that existing depth is surveyed
There are scintillation crystal cutting technique difficulty is big, of high cost, time-consuming, uniformity is difficult to control, interacts deeply in amount detector
Spend the discontinuous technical problem of information.
In order to achieve the above objectives, scheme provided by the invention is:Depth survey detector cells, including two intervals side by side
The scintillation crystal of setting and two spacing side by side set and are respectively arranged on the photodetector of two described scintillation crystal one end, two
Gap between the scintillation crystal is included close to the first layer space of the photodetector, away from the photodetector
Second layering space and positioned at the first layer space and it is described second layering space between the 3rd layering space, it is described
Filled with the first reflectance coating in first layer space, optical coupled body is filled in the second layering space, described 3rd point
Air is filled in sheaf space.
Optionally, the 3rd layering space is stuffed entirely with air.
Alternatively, it is filled with air and the second reflectance coating in the 3rd layering space.
Optionally, second reflectance coating extends to the optical coupled body in triangular shape from first reflectance coating;And/
Or,
First reflectance coating and second reflectance coating are made of identical material.
Optionally, the scintillation crystal has the signal output part towards the photodetector, and the depth survey is visited
It surveys device unit and further includes that be coated on two scintillation crystals outer and avoid the 3rd reflectance coating of the signal output part, described the
Three reflectance coatings are made with first reflectance coating of identical material.
Optionally, the shape of the scintillation crystal is cuboid.
Optionally, there are two respectively close to the first layer space and the described second layering space for the scintillation crystal tool
End face and four respectively connect two end faces four edges side, two polished processing in end face, four institutes
Side is stated without polishing treatment;And/or
The size of the scintillation crystal is 3mm*3mm*20mm.
Optionally, the photodetector is silicon photomultiplier either more pixel photon counters or photomultiplier
Or avalanche photodiode;And/or
The material of the optical coupled body is optical cement or optic grease;And/or
The material of the scintillation crystal is yttrium luetcium silicate either silicic acid lutetium or sodium iodide or lanthanum bromide;And/or
First reflectance coating is ESR;And/or
The first layer space, the second layering space and the 3rd layering space are all rectangular.
Second object of the present invention is to provide a kind of depth of interaction computational methods of depth survey detector cells,
Embodiment is:Energy signal acquisition is carried out to two scintillation crystals respectively using two photodetectors, is defined described in two
The energy signal that photodetector collects is respectively the depth of interaction information of E1 and E2, then the two scintillation crystals
Difference can be obtained by E1/ (E1+E2), E2/ (E1+E2).
Third object of the present invention is to provide a kind of detector, including multiple above-mentioned depth survey detector lists
Member, each depth survey detector cells are by photodetector towards being divided into several rows and several columns arrangement in a manner of consistent.
The depth of interaction of depth survey detector cells provided by the invention, detector and depth survey detector cells
Computational methods are respectively coupled in by using the first reflectance coating, air and optical coupled body between two identical scintillation crystals
Different position, so as to realize that crystal different depth light shares the area of degree by different length and shape combined methods
Point.In concrete application, the passage of scintillation light of two scintillation crystals is acquired and is converted to respectively using two photodetectors
Then energy information can obtain depth of interaction of the gamma ray in crystal by calculating the energy ratio of two photodetectors
Information.Compared with prior art, depth survey detector cells provided by the invention, detector and depth survey detector list
The depth of interaction computational methods of member need not carry out laser treatment, so as to effectively reduce with depth survey to scintillation crystal
The realization difficulty and cost of the detector of ability;And its depth of interaction information is continuous, uniformity is more preferable, temporal resolution
More preferably.
Description of the drawings
It in order to illustrate more clearly about the embodiment of the present invention or technical scheme of the prior art, below will be to embodiment or existing
There is attached drawing needed in technology description to be briefly described, it should be apparent that, the accompanying drawings in the following description is only this
Some embodiments of invention, for those of ordinary skill in the art, without creative efforts, can be with
Structure according to these attached drawings obtains other attached drawings.
Fig. 1 is the volume rendering schematic diagram for the depth survey detector cells that the embodiment of the present invention one provides;
Fig. 2 is the coupled structure schematic diagram between two scintillation crystals that the embodiment of the present invention one provides;
Fig. 3 is the volume rendering schematic diagram for the detector that the embodiment of the present invention one provides;
Fig. 4 is the coupled structure schematic diagram between two scintillation crystals provided by Embodiment 2 of the present invention.
Specific embodiment
Below in conjunction with the attached drawing in the embodiment of the present invention, the technical solution in the embodiment of the present invention is carried out clear, complete
Site preparation describes, it is clear that described embodiment is only the part of the embodiment of the present invention, instead of all the embodiments.Base
Embodiment in the present invention, those of ordinary skill in the art obtained without creative efforts it is all its
His embodiment, belongs to the scope of protection of the invention.
It is to be appreciated that the directional instruction (such as up, down, left, right, before and after ...) of institute is only used in the embodiment of the present invention
In explaining relative position relation, motion conditions under a certain particular pose (as shown in drawings) between each component etc., if should
When particular pose changes, then directionality instruction also correspondingly changes correspondingly.
It should also be noted that, when element is referred to as on " being fixed on " or " being arranged at " another element, it can be straight
It is connected on another element or may be simultaneously present centering elements.When an element is known as " connection " another element,
It can be directly connected to another element or may be simultaneously present centering elements.
In addition, the description for being related to " first ", " second " etc. in the present invention is only used for description purpose, and it is not intended that referring to
Show or imply its relative importance or imply the quantity of the technical characteristic indicated by indicating." first ", " are defined as a result,
At least one this feature can be expressed or be implicitly included to two " feature.In addition, the technical solution between each embodiment can
To be combined with each other, but must can be implemented as basis with those of ordinary skill in the art, when the combination of technical solution occurs
Conflicting or can not realize when, will be understood that the combination of this technical solution is not present, also not the present invention claims protection model
Within enclosing.
Embodiment one:
As shown in Figs. 1-3, the depth survey detector cells 100 that the embodiment of the present invention one provides, including two intervals simultaneously
It arranges the scintillation crystal 1 set and two spacing side by side sets and are respectively arranged on the photodetector 2 of two scintillation crystals, 1 one end, two
Gap between a scintillation crystal 1 is included close to the first layer space of photodetector 2, second away from photodetector 2
Space and the 3rd layering space between first layer space and the second layering space are layered, is filled in first layer space
There is the first reflectance coating 3, optical coupled body 4 is filled in the second layering space, air 5 is filled in the 3rd layering space.This reality
The depth survey detector cells 100 of example offer are provided, distinguish coupling by using the first reflectance coating 3, air 5 and optical coupled body 4
The different position between two identical scintillation crystals 1 is closed, so as to be realized by different length and shape combined methods
Crystal different depth light shares the differentiation of degree.In concrete application, using two photodetectors 2 respectively to two scintillation crystals
1 passage of scintillation light is acquired and is converted to energy information, then can be obtained by calculating the energy ratio of two photodetectors 2
To depth-of-interaction information of the gamma ray in crystal.Depth survey detector cells 100 provided in this embodiment, need not pair
Scintillation crystal 1 carries out laser treatment, so as to effectively reduce the realization difficulty of the detector with depth survey ability and cost;
And its depth of interaction information is continuous, uniformity is very good, and temporal resolution is also very good.
Preferably, the material of scintillation crystal 1 is yttrium luetcium silicate.Yttrium luetcium silicate scintillation crystal 1 (LYSO) have High Light Output,
Fast decay of luminescence, effective atomic number is more, physico-chemical property is stable, not characteristics such as deliquescence, efficient to gamma-ray detection.Certainly
, in concrete application, scintillation crystal 1 can also be used other materials and be made, such as silicic acid lutetium (LSO), sodium iodide (NaI), bromination
Lanthanum (LaBr3) etc..
Preferably, the shape of scintillation crystal 1 is cuboid, regular shape, simple in structure, easily fabricated.
Preferably, the size of scintillation crystal 1 is 3mm*3mm*20mm.It of courses, in concrete application, the ruler of scintillation crystal 1
It is very little without being limited thereto.
Preferably, scintillation crystal 1 has the signal output part towards photodetector 2, and the signal of two scintillation crystals 1 is defeated
Outlet is located at the same side, and two photodetectors 2 align with the signal output part of two scintillation crystals 1 set respectively.Scintillation crystal 1
There are two respectively close to end face of the first layer space with the second layering space and four four sides for being connected two end faces respectively for tool
The side of edge, two polished processing in end face, four sides are without polishing treatment.Herein, scintillation crystal 1 there are two end face into
Row polishing treatment, four sides need not all be processed by shot blasting, dramatically reduce scintillation crystal 1 manufacture difficulty and
Manufacture cost.
Preferably, first layer space, the second layering space and the 3rd layering space are all rectangular.First layer space,
3rd layering space and the second layering space are vertically continuously distributed successively.
Preferably, the first reflectance coating 3 is enhanced optical reflection film (Enhanced Specular Reflector, abbreviation
ESR), reflectivity is high.ESR is silver-colored reflectance coating, is to have to use PET systems resin as multi-layer film structure made of raw material, together
When be also the optical thin film for having very high reflectivity in visible wavelength range, and ESR is in addition to high reflectance
It is unlikely to have apparent colour cast.It of courses, in concrete application, ESR also can be replaced the higher layer of reflective material of other reflectance factors.
Preferably, the material of optical coupled body 4 is optical cement.Herein, optical coupled body 4 uses high light transmittance and refractive index
With scintillation crystal 1 similar in optical cement coupled, beneficial to realize passage of scintillation light good transmission.It of courses, in concrete application, light
Other high light transmittances can also be used for coupling body 4 and refractive index is made with material similar in scintillation crystal 1, such as optic grease
Deng.
Preferably, photodetector 2 is silicon photomultiplier (Silicon photomultiplier, abbreviation SiPM),
Have the characteristics that high gain, high sensitivity, biased electrical are forced down, are insensitive to magnetic field, is compact-sized.It of courses, in concrete application,
Other Instruments replacement, such as more pixel photon counters (Multi Pixel Photo can also be used in silicon photomultiplier
Counter, abbreviation MPPC) either photomultiplier (Photomultiplier Tube abbreviation PMT) or avalanche photodiode
(Avalanche Photo Diode, abbreviation APD) etc..
Preferably, the 3rd layering space is stuffed entirely with air 5.In this preferred embodiment, between two scintillation crystals 1
It reads close to signal and is isolated at end using the reflecting material of high reflectance, while be bonded using optical cement;It is intermediate
Part does not process, and is only isolated by air 5;Top is using high light transmittance and refractive index and light similar in scintillation crystal 1
It learns coupling body 4 to be coupled, realizes the good transmission of passage of scintillation light.It of courses, in concrete application, is grown for the coupling of different materials
Degree can be adjusted as needed.
Preferably, depth survey detector cells 100, which further include, is coated on outside two scintillation crystals 1 and avoids signal output
3rd reflectance coating at end, the 3rd reflectance coating material identical with 3 use of the first reflectance coating are made.Depth survey detector cells
100 in addition to outer surface where signal output part, remaining has all coated the 3rd reflectance coating.Herein, the first reflectance coating 3 and the 3rd
Reflectance coating is made of identical material, in this way, beneficial to the manufacture difficulty and cost that reduce depth survey detector cells 100.
As a preferred embodiment of the present embodiment, the size of scintillation crystal 1 is 3mm*3mm*20mm, the first reflectance coating
3 be the cuboid ESR reflectance coatings of 6mm high, and the 3rd is layered cuboid air 5 layer of the air 5 in space for 8mm high, optics coupling
Zoarium 4 is the cuboid optical cement of 6mm high;Through carrying out detection experiment using the photodetector 2 of 3mm, obtained mean depth
Good resolution is in 4mm.
Further, the present embodiment additionally provides the depth of interaction computational methods of depth survey detector cells 100, in fact
The mode of applying is:Energy signal acquisition is carried out to two scintillation crystals 1 respectively using two photodetectors 2, defines two photoelectricity
The energy signal that detector 2 collects is respectively E1And E2, then the depth of interaction information of the two scintillation crystals 1 respectively can
By E1/(E1+E2)、E2/(E1+E2) obtain.The depth of interaction calculating side of depth survey detector cells 100 provided in this embodiment
Method, as a result of above-mentioned depth survey detector cells 100, therefore, the feelings of laser treatment can not be being carried out to scintillation crystal 1
Under shape, the survey calculation of continuous depth of interaction is realized, the realization for effectively reducing the calculating of detector depth of interaction is difficult
Degree and cost, and its depth resolution is high, temporal resolution is high, uniformity is good.
As a preferred embodiment of the present embodiment, the depth of interaction computational methods of depth survey detector cells 100
Embodiment be:Two sizes is used to carry out energy signal to above-mentioned depth survey detector cells 100 for the SiPM of 3mm to adopt
Collection defines the energy that two SiPM and SiPM are collected and corresponds to E respectively1And E2, pass through the energy of one end and the ratio of gross energy
E1/(E1+E2)、E2/(E1+E2) depth of interaction (Depth of interaction, abbreviation DOI) information is obtained, different depth obtains
To DOI ratios will the different and different of degree be shared due to light.
The depth of interaction computational methods of depth survey detector cells 100 provided in this embodiment are visited using single-ended photoelectricity
Device 2 and individual layer scintillation crystal 1 are surveyed, the method shared by 1 light of scintillation crystal realizes the measurement of continuous depth of interaction,
Its consistency is good, and temporal resolution is low;And since it need not carry out laser treatment to scintillation crystal 1, therefore, effectively reduce reality
Existing difficulty and cost.
Further, the present embodiment additionally provides detector, including multiple above-mentioned depth survey detector cells
100, each depth survey detector cells 100 are by photodetector 2 towards being divided into several rows and several columns arrangement in a manner of consistent.
Detector provided in this embodiment, as a result of above-mentioned depth survey detector cells 100, therefore, it can realize continuous
The measurement of depth of interaction, and its depth resolution is high, temporal resolution is high, uniformity is good, and its is compact-sized, manufacture is difficult
Spend it is low, manufacture it is at low cost.
Preferably, depth survey detector cells 100 are equipped with 32, the quantity of scintillation crystal and photodetector 2
All it is 64.Herein, detector is composed of the scintillation crystal 1 of 8*8 arrays and the photodetector 2 of 8*8 arrays,
The SiPM arrays that 8*8 can be achieved carry out signal reading.It of courses, in concrete application, the quantity of depth survey detector cells 100
It is without being limited thereto.
Detector provided in this embodiment is measured mutually by the principle that light between crystal is shared using SiPM arrays
The single-ended reading single layer crystal detector array of depth of interaction (Depth of interaction, abbreviation DOI), structure are tight
It gathers, manufacture difficulty is low, and manufacture is at low cost, and with continuous high depth resolution and high time resolution.
Embodiment two:
The effect of depth survey detector provided in this embodiment, detector and depth survey detector cells 100 is deep
Computational methods are spent, the filler that the difference with embodiment one is essentially consisted in the 3rd layering space is different, embodies
:As shown in Figs. 1-3, in embodiment one, air 5 is stuffed entirely in the 3rd layering space, i.e. between two scintillation crystals 1 in
Between part do not process, only isolated by air 5;And as shown in figure 4, in the present embodiment, it is filled in the 3rd layering space
There is 5 and second reflectance coating 6 of air, i.e. center section between two scintillation crystals 1 is also additional while isolating using air 5
It is additionally arranged the 3rd reflectance coating.In the present embodiment, due to being also to be respectively coupled in two identical flicker crystalline substances by using different materials
Different position between body 1, therefore, it can realize that crystal different depth light is shared by different length and shape combined methods
The differentiation of degree, and laser treatment is carried out also without to scintillation crystal 1 in the present embodiment, therefore, realize difficulty and cost
It is very low, and its depth of interaction information is also continuous, uniformity is also very good, and temporal resolution is also very good.
Preferably, the second reflectance coating 6 extends to optical coupled body 4 in triangular shape from the first reflectance coating 3.Specifically, second
Reflectance coating 6 extends to optical coupled body 4 in the form of width is gradually reduced from the first reflectance coating 3, and the 3rd is layered remaining in space
Part is air 5.
Preferably, the first reflectance coating 3 and the second reflectance coating 6 are made of identical material, in this way, being surveyed beneficial to depth is reduced
Measure the manufacture difficulty and cost of detector cells 100.
Preferably, the first reflectance coating 3 and the second reflectance coating 6 are all the enhanced optical reflection film (ESR) of high reflectance.Certainly
, in concrete application, the higher reflector material system of other reflectance factors can also be used in the first reflectance coating 3 and the second reflectance coating 6
Into.
As a preferred embodiment of the present embodiment, the size of scintillation crystal 1 is 3mm*3mm*20mm, the first reflectance coating
3 be the cuboid ESR reflectance coatings of 6mm high, and the second reflectance coating 6 is the triangle ESR reflectance coatings of 9mm high, and optical coupled body 4 is
The optical cement of 5mm high, the 3rd rest part for being layered in space in addition to the second reflectance coating 6 is air 5.Through the light using 3mm
Electric explorer 2 carries out detection experiment, and obtained mean depth good resolution is in 3.5mm.
Except it is above-mentioned it is different in addition to, depth survey detector provided in this embodiment, detector and depth survey detection
Other set-up modes of the depth of interaction computational methods of device unit 100 all can refer to embodiment one and carry out corresponding optimization design,
This is no longer described in detail.
The foregoing is merely the preferred embodiment of the present invention, are not intended to limit the scope of the invention, every at this
The equivalent structure transformation made under the inventive concept of invention using description of the invention and accompanying drawing content or directly/utilization indirectly
It is included in other related technical areas in the scope of patent protection of the present invention.
Claims (10)
1. depth survey detector cells, which is characterized in that be spaced the scintillation crystal that is arranged side by side and two side by side including two
It is arranged at intervals and is respectively arranged on the photodetector of two described scintillation crystal one end, the gap bag between two scintillation crystals
It includes second close to the first layer space of the photodetector, away from the photodetector and is layered space and positioned at described
The 3rd between first layer space and the second layering space is layered space, and first is filled in the first layer space
Reflectance coating, described second is layered in space filled with optical coupled body, and the described 3rd is layered in space filled with air.
2. depth survey detector cells as described in claim 1, which is characterized in that the 3rd layering space is stuffed entirely with
Air.
3. depth survey detector cells as described in claim 1, which is characterized in that be filled in the 3rd layering space
Air and the second reflectance coating.
4. depth survey detector cells as claimed in claim 3, which is characterized in that second reflectance coating in triangular shape from
First reflectance coating extends to the optical coupled body;And/or
First reflectance coating and second reflectance coating are made of identical material.
5. depth survey detector cells as described in claim 1, which is characterized in that the scintillation crystal has described in
The signal output part of photodetector, the depth survey detector cells further include be coated on two scintillation crystals it is outer and
The 3rd reflectance coating of the signal output part is avoided, the 3rd reflectance coating uses identical material system with first reflectance coating
Into.
6. such as depth survey detector cells described in any one of claim 1 to 5, which is characterized in that the scintillation crystal
Shape is cuboid.
7. depth survey detector cells as claimed in claim 6, which is characterized in that there are two respectively for the scintillation crystal tool
Close to end face of the first layer space with the described second layering space and four four sides for being connected two end faces respectively
The side of edge, two polished processing in end face, four sides are without polishing treatment;And/or
The size of the scintillation crystal is 3mm*3mm*20mm.
8. such as depth survey detector cells described in any one of claim 1 to 5, which is characterized in that the photodetector
For silicon photomultiplier either more pixel photon counters or photomultiplier or avalanche photodiode;And/or
The material of the optical coupled body is optical cement or optic grease;And/or
The material of the scintillation crystal is yttrium luetcium silicate either silicic acid lutetium or sodium iodide or lanthanum bromide;And/or
First reflectance coating is ESR;And/or
The first layer space, the second layering space and the 3rd layering space are all rectangular.
9. the depth of interaction computational methods of depth survey detector cells as described in any one of claim 1 to 7, feature exist
In embodiments thereof is:Energy signal acquisition is carried out to two scintillation crystals respectively using two photodetectors, defines two
The energy signal that the photodetector collects is respectively E1And E2, then the depth of interaction of the two scintillation crystals
Information respectively can be by E1/(E1+E2)、E2/(E1+E2) obtain.
10. detector, which is characterized in that including multiple depth survey detector lists as described in any one of claim 1 to 7
Member, each depth survey detector cells are by photodetector towards being divided into several rows and several columns arrangement in a manner of consistent.
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