CN108101827A - A kind of synthetic method of pabishta key intermediate - Google Patents
A kind of synthetic method of pabishta key intermediate Download PDFInfo
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- CN108101827A CN108101827A CN201711489659.8A CN201711489659A CN108101827A CN 108101827 A CN108101827 A CN 108101827A CN 201711489659 A CN201711489659 A CN 201711489659A CN 108101827 A CN108101827 A CN 108101827A
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- Prior art keywords
- methyl
- synthetic method
- crude product
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- water
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- ZBJZNHMRSGUKFA-UHFFFAOYSA-N COC(CCc1ccc(C=O)cc1)O Chemical compound COC(CCc1ccc(C=O)cc1)O ZBJZNHMRSGUKFA-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
Abstract
The invention belongs to pharmaceutical synthesis fields, more particularly to a kind of synthetic method of pabishta key intermediate, the key intermediate is (E) 3 [4 [[[2 (2 methyl 1H indoles, 3 base) ethyl] amino] methyl] phenyl] methyl acrylate hydrochloride, the method of the present invention yield may be up to more than 85%, and impurity is few, purity more than 99.5%, at the same it is easy to operate.
Description
Technical field
The invention belongs to pharmaceutical synthesis fields, and in particular to a kind of synthetic method of pabishta key intermediate.
Background technology
Pabishta, the drug for being used to treat Huppert's disease (MM) of Novartis Co., Ltd's exploitation, U.S.'s food and drug
Supervision Bureau (FDA) is N- hydroxyls -3- [4- [[[2- (2- methyl-1 H- Yin in approval listing on 2 23rd, 2015, chemical name
Diindyl -3- bases)-ethyl]-amino] methyl] phenyl] -2E-2- acrylamides, chemical constitution is shown in formula I：
Novartis Co., Ltd discloses pabishta compound and preparation method thereof in international application for patent WO02/22577A2,
Using 2- methyl -3- indoles-oxamides as raw material, after Lithium Aluminium Hydride reduces to obtain 2- methyltryptamines, with 4- formyls-cinnamic acid first
Ester reaction, rehydrated hydrazinolysis obtain pabishta, and reaction scheme is as follows：
Novartis Co., Ltd discloses the synthesis side of another pabishta in international application for patent WO2007/146718A2
Method, this method use phenylhydrazine as raw material, through 2- methyltryptamines are obtained by the reaction with the chloro- 2 pentanones of 5-, with 4- formyls-methyl cinnamate
Reaction, rehydrated hydrazinolysis obtain pabishta, and reaction scheme is as follows：
Which, no matter using route preparation pabishta, it is required for using key intermediate (E) -3- [4- [[[2- (2- first
Base -1H- indol-3-yls) ethyl] amino] methyl] phenyl] methyl acrylate hydrochloride, structure as shown in Formula II,
But the purity and yield of the intermediate is not high always, becomes the obstacle of high-purity pabishta preparation, is also pa ratio
It takes charge of his bulk pharmaceutical chemicals quality control and improves difficulty.
The content of the invention
The object of the present invention is to provide one kind (E) -3- [4- [[[2- (2- Methyl-1H-indole -3- bases) ethyl] amino] first
Base] phenyl] methyl acrylate hydrochloride preparation method, the method yield may be up to more than 85%, and impurity is few, purity
More than 99.5%, at the same it is easy to operate.
For achieving the above object, the present invention provides following technical scheme：
A kind of synthetic method of pabishta key intermediate, comprises the following steps：
Step (1)：Using 2- methyltryptamines and (E) -3- (4- Fonnylphenyls) methyl acrylate as raw material, react and Asia is made
After amine compounds, reduced under pd-C/H2 and (E) -3- [4- [[[2- (2- Methyl-1H-indole -3- bases) ethyl] amino] first is made
Base] phenyl] methyl acrylate crude product；
Step (2)：By crude product obtained by step (1) in alcohols solvent with hydrogen chloride into salt, add in ketones solvent and water weight
It crystallizes to obtain the final product, the volume ratio of the alcohols solvent, ketones solvent and water is 10-15:5-10:1, in terms of crude product obtained by step (1),
It is 2-10ml that crude product obtained by per g steps (1), which needs the total volume of the alcohols solvent, ketones solvent and water,.
Synthetic method according to the present invention, the dosage of pd-C is the 0.01-0.1 times of weight of 2- methyltryptamines in step (1)；
Preferably, in step (1) dosage of pd-C be 2- methyltryptamines 0.05-0.1 times of weight.
Synthetic method according to the present invention, the alcohols solvent described in step (2) are selected from methanol, ethyl alcohol, propyl alcohol, isopropanol
With the one or more in butanol；Preferably, the one kind or more of the alcohols solvent described in step (2) in methanol and ethyl alcohol
Kind；It is further preferred that the alcohols solvent described in step (2) is the one or more in methanol.
Synthetic method according to the present invention, the ketones solvent described in step (2) are selected from acetone, methyl ethyl ketone, cyclohexanone, first
Base butanone and methylisobutylketone；Preferably, the ketones solvent described in step (2) is selected from acetone, methyl ethyl ketone and espeleton；Into
Preferably, the ketones solvent described in step (2) is acetone to one step.
Synthetic method according to the present invention, the volume ratio of alcohols solvent, ketones solvent and water described in step (2) are
10-15:5:1；Preferably, the volume ratio of the alcohols solvent described in step (2), ketones solvent and water is 12:5:1.
Synthetic method according to the present invention, in terms of crude product obtained by step (1), crude product needs the alcohols obtained by per g steps (1)
The total volume of solvent, ketones solvent and water is 2-5ml.
Specific embodiment
Raw material 2- methyltryptamine reference literatures CN201110062948 is prepared, (E) -3- (4- Fonnylphenyls) propylene
Sour methyl esters and other reagents are commercially available.
Embodiment 1 (E) -3- [4- [[[2- (2- Methyl-1H-indole -3- bases) ethyl] amino] methyl] phenyl] acrylic acid
The preparation of methyl ester hydrochloride
It weighs 5.0g 2- methyltryptamines and 5.75g (E) -3- (4- Fonnylphenyls) methyl acrylate in reaction bulb, adds
Entering methanol 50ml dissolvings, stir 1h at room temperature, add in palladium carbon 0.05g, continue to stir 4h under room temperature, atmosphere of hydrogen, reaction terminates,
Diatomite filters, and removes solvent under reduced pressure and obtains (E) -3- [4- [[[2- (2- Methyl-1H-indole -3- bases) ethyl] amino] methyl] benzene
Base] methyl acrylate crude product.
Weigh (E) -3- [4- [[[2- (2- Methyl-1H-indole -3- bases) ethyl] amino] methyl] phenyl] third obtained by 4.5g
E pioic acid methyl ester crude product is dissolved in 10ml methanol, and hydrogen chloride methanol solution 2.4g is added dropwise, and stirs 0.5h at room temperature, adds in acetone 5ml,
Water 1ml places 8h at 0-4 DEG C, obtains title compound 5.53g, yield 90%, HPLC detection purity 99.8%.
Embodiment 2 (E) -3- [4- [[[2- (2- Methyl-1H-indole -3- bases) ethyl] amino] methyl] phenyl] acrylic acid
The preparation of methyl ester hydrochloride
It weighs 5.0g 2- methyltryptamines and 5.75g (E) -3- (4- Fonnylphenyls) methyl acrylate in reaction bulb, adds
Entering methanol 50ml dissolvings, stir 1h at room temperature, add in palladium carbon 0.25g, continue to stir 4h under room temperature, atmosphere of hydrogen, reaction terminates,
Diatomite filters, and removes solvent under reduced pressure and obtains (E) -3- [4- [[[2- (2- Methyl-1H-indole -3- bases) ethyl] amino] methyl] benzene
Base] methyl acrylate crude product.
Weigh (E) -3- [4- [[[2- (2- Methyl-1H-indole -3- bases) ethyl] amino] methyl] phenyl] third obtained by 3.0g
E pioic acid methyl ester crude product is dissolved in 12ml ethyl alcohol, and hydrogen chloride methanol solution 1.6g is added dropwise, and stirs 0.5h at room temperature, adds in acetone 5ml,
Water 1ml places 8h at 0-4 DEG C, obtains title compound 3.1g, yield 88%, HPLC detection purity 99.8%.
Embodiment 3 (E) -3- [4- [[[2- (2- Methyl-1H-indole -3- bases) ethyl] amino] methyl] phenyl] acrylic acid
The preparation of methyl ester hydrochloride
It weighs 5.0g 2- methyltryptamines and 5.75g (E) -3- (4- Fonnylphenyls) methyl acrylate in reaction bulb, adds
Entering methanol 50ml dissolvings, stir 1h at room temperature, add in palladium carbon 0.25g, continue to stir 4h under room temperature, atmosphere of hydrogen, reaction terminates,
Diatomite filters, and removes solvent under reduced pressure and obtains (E) -3- [4- [[[2- (2- Methyl-1H-indole -3- bases) ethyl] amino] methyl] benzene
Base] methyl acrylate crude product.
Weigh (E) -3- [4- [[[2- (2- Methyl-1H-indole -3- bases) ethyl] amino] methyl] phenyl] third obtained by 3.0g
E pioic acid methyl ester crude product is dissolved in 10ml methanol, and hydrogen chloride methanol solution 1.6g is added dropwise, and stirs 0.5h at room temperature, adds in methyl ethyl ketone
5ml, water 1ml place 8h at 0-4 DEG C, obtain title compound 3.55g, yield 93%, HPLC detection purity 99.5%.
Although being described in detail above to the present invention, however it is understood by skilled practitioners that without departing from this hair
The present invention can be carry out various modifications and changed on the premise of bright spirit and scope.The interest field of the present invention is not limited to
The detailed description made above, and claims should be belonged to.
Claims (6)
1. a kind of synthetic method of pabishta key intermediate, comprises the following steps：
Step (1)：Using 2- methyltryptamines and (E) -3- (4- Fonnylphenyls) methyl acrylate as raw material, react and imidization is made
After closing object, reduced under pd-C/H2 and (E) -3- [4- [[[2- (2- Methyl-1H-indole -3- bases) ethyl] amino] methyl] are made
Phenyl] methyl acrylate crude product；
Step (2)：Crude product obtained by step (1) is recrystallized in alcohols solvent with hydrogen chloride into salt, addition ketones solvent and water
To obtain the final product, the volume ratio of the alcohols solvent, ketones solvent and water is 10-15:5-10:1, in terms of crude product obtained by step (1), per g
It is 2-10ml that crude product obtained by step (1), which needs the total volume of the alcohols solvent, ketones solvent and water,.
2. synthetic method according to claim 1, it is characterised in that：The dosage of pd-C is 2- methyltryptamines in step (1)
0.01-0.1 times of weight；Preferably, in step (1) dosage of pd-C be 2- methyltryptamines 0.05-0.1 times of weight.
3. synthetic method according to claim 1, it is characterised in that：Alcohols solvent described in step (2) be selected from methanol,
One or more in ethyl alcohol, propyl alcohol, isopropanol and butanol；Preferably, the alcohols solvent described in step (2) be selected from methanol and
One or more in ethyl alcohol；It is further preferred that the alcohols solvent described in step (2) is the one or more in methanol.
4. synthetic method according to claim 1, it is characterised in that：Ketones solvent described in step (2) be selected from acetone,
Methyl ethyl ketone, cyclohexanone, espeleton and methylisobutylketone；Preferably, the ketones solvent described in step (2) is selected from acetone, first
Ethyl ketone and espeleton；It is further preferred that the ketones solvent described in step (2) is acetone.
5. synthetic method according to claim 1, it is characterised in that：Alcohols solvent, ketones solvent described in step (2)
Volume ratio with water is 10-15:5:1；Preferably, the volume ratio of the alcohols solvent described in step (2), ketones solvent and water is
12:5:1。
6. synthetic method according to claim 1, it is characterised in that：In terms of crude product obtained by step (1), per g step (1) institute
It is 2-5ml to obtain crude product and need the total volume of the alcohols solvent, ketones solvent and water.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711489659.8A CN108101827A (en) | 2017-12-30 | 2017-12-30 | A kind of synthetic method of pabishta key intermediate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711489659.8A CN108101827A (en) | 2017-12-30 | 2017-12-30 | A kind of synthetic method of pabishta key intermediate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108101827A true CN108101827A (en) | 2018-06-01 |
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| CN201711489659.8A Withdrawn CN108101827A (en) | 2017-12-30 | 2017-12-30 | A kind of synthetic method of pabishta key intermediate |
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2017
- 2017-12-30 CN CN201711489659.8A patent/CN108101827A/en not_active Withdrawn
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