CN108053866B - Method, device and equipment for transmitting working curve and storage medium - Google Patents
Method, device and equipment for transmitting working curve and storage medium Download PDFInfo
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Abstract
The invention provides a method, a device, equipment and a storage medium for transmitting a working curve, and relates to the field of biotechnology. The transfer method of the working curve comprises the following steps: obtaining the bottle opening time of a target bottle reagent, and detecting whether the bottle opening time of the target bottle reagent exceeds a reagent characteristic safety time threshold value or not, wherein the target bottle reagent is one bottle of reagents in a plurality of bottles of reagents in the same batch; if the bottle opening time of the target bottle reagent exceeds the reagent characteristic safety time threshold, judging whether the reagent batch of the target bottle reagent corresponds to a reagent batch working curve; and if the reagent batch of the target bottle reagent corresponds to the reagent batch working curve, transferring the reagent batch working curve corresponding to the reagent batch of the target bottle reagent for use. By using the technical scheme of the invention, the accuracy of the detection result of the clinical specimen detection by using the reagent batch working curve can be improved.
Description
Technical Field
The invention relates to the field of biotechnology, in particular to a method, a device, equipment and a storage medium for transmitting a working curve.
Background
In the development of biotechnology, clinical specimen detection is generally required. A variety of reagents are used in clinical specimen testing. In order to ensure the accuracy of the clinical specimen detection, a standard specimen with a known concentration needs to be calibrated by using a reagent before the clinical specimen detection is performed, so as to obtain a working curve of the reagent, thereby obtaining the actual performance of the reagent in the current experimental environment and the instrument environment.
The composition ratios of the reagents of the same batch carrying out the same project are completely the same, that is, the working curves of the reagents of the same batch carrying out the same project are basically consistent, and it is not necessary to calibrate each bottle of the reagents of the same batch. When the detection is carried out in the same experimental environment and the same instrument, the working curve of any bottle of reagent in the same batch can be transmitted to other bottles of reagent in the same batch for use, and the transmission of the working curve of the reagent is realized. However, the reagent operating curve may vary due to different usage times of reagents of the same lot, i.e., different decap times of reagents of the same lot. Therefore, the working curve of any bottle of reagent in the same batch is used for transmission, and the accuracy of the detection result of clinical specimen detection by using the working curve is reduced.
Disclosure of Invention
The embodiment of the invention provides a method, a device, equipment and a storage medium for transmitting a working curve, which can improve the accuracy of transmitting a reagent batch working curve and further improve the accuracy of a detection result of clinical specimen detection by using the transmitted reagent batch working curve.
In a first aspect, an embodiment of the present invention provides a method for transferring a working curve, including: obtaining the bottle opening time of a target bottle reagent, and detecting whether the bottle opening time of the target bottle reagent exceeds a reagent characteristic safety time threshold value or not, wherein the target bottle reagent is one bottle of reagents in a plurality of bottles of reagents in the same batch; if the bottle opening time of the target bottle reagent exceeds the reagent characteristic safety time threshold, judging whether the reagent batch of the target bottle reagent corresponds to a reagent batch working curve; and if the reagent batch of the target bottle reagent corresponds to the reagent batch working curve, transferring the reagent batch working curve corresponding to the reagent batch of the target bottle reagent for use.
In a second aspect, an embodiment of the present invention provides an apparatus for transferring an operating curve, including: the first detection module is configured to acquire the bottle opening time of a target bottle of reagent, and detect whether the bottle opening time of the target bottle of reagent exceeds a reagent characteristic safety time threshold value, wherein the target bottle of reagent is one bottle of reagent in multiple bottles of reagents in the same batch; the first judgment module is configured to judge whether a reagent batch in which the target bottle reagent is located corresponds to a reagent batch working curve or not if the bottle opening time of the target bottle reagent exceeds a reagent characteristic safety time threshold; and the first determination module is configured to transfer the reagent batch working curve corresponding to the reagent batch in which the target bottle reagent is located for use if the reagent batch in which the target bottle reagent is located corresponds to the reagent batch working curve.
In a third aspect, an embodiment of the present invention provides a device for transferring an operating curve, including a memory, a processor, and a program stored in the memory and executable on the processor, where the processor implements the method for transferring an operating curve in the foregoing technical solution when executing the program.
In a fourth aspect, an embodiment of the present invention provides a storage medium, where a program is stored on the storage medium, and when the program is executed by a processor, the method for transferring an operating curve in the foregoing technical solution is implemented.
The embodiment of the invention provides a transmission method, a transmission device, equipment and a storage medium of a working curve, and whether the bottle opening time of a reagent exceeds a safety time threshold of the reagent characteristic is considered in the process of judging the reagent batch working curve of the reagent of the same batch. Under the condition that the reagent batch of the target bottle reagent corresponds to the reagent batch working curve and the bottle opening time of the target bottle reagent exceeds the reagent characteristic safety time threshold, the reagent batch working curve of the reagent batch of the target bottle reagent is preferentially adopted and is used as the latest reagent batch working curve of the reagent batch of the target bottle reagent. The current calibration working curve of the reagent with the bottle opening time exceeding the safety time threshold of the reagent characteristic is prevented from being used as the latest reagent batch working curve; namely, the working curve of the reagent with the difference change generated by the working curve compared with other reagents with the bottle opening time not exceeding the safety time threshold of the reagent characteristic is avoided to be used as the latest working curve of the reagent batch. Therefore, the transmission of the working curve which is not accurately used is avoided, the transmission accuracy of the reagent batch working curve is improved, and the accuracy of the detection result of the clinical specimen detection by using the reagent batch working curve is improved.
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The invention will be better understood from the following description of specific embodiments thereof, taken in conjunction with the accompanying drawings. Wherein like or similar reference numerals refer to like or similar features.
FIG. 1 is a flow chart of a method for transferring a working curve according to an embodiment of the present invention;
FIG. 2 is a flow chart of a method for transferring an operation curve according to another embodiment of the present invention;
FIG. 3 is a flow chart of a method for transferring an operation curve according to another embodiment of the present invention;
FIG. 4 is a schematic structural diagram of a device for transferring an operating curve according to an embodiment of the present invention;
FIG. 5 is a schematic structural diagram of a device for transferring an operating curve according to another embodiment of the present invention;
FIG. 6 is a schematic structural diagram of a device for transferring an operating curve according to another embodiment of the present invention;
fig. 7 is a schematic hardware structure diagram of an operation curve transmission device according to an embodiment of the present invention.
Detailed Description
Features and exemplary embodiments of various aspects of the present invention will be described in detail below. In the following detailed description, numerous specific details are set forth in order to provide a thorough understanding of the present invention. It will be apparent, however, to one skilled in the art that the present invention may be practiced without some of these specific details. The following description of the embodiments is merely intended to provide a better understanding of the present invention by illustrating examples of the present invention. The present invention is in no way limited to any specific configuration and algorithm set forth below, but rather covers any modification, replacement or improvement of elements, components or algorithms without departing from the spirit of the invention. In the drawings and the following description, well-known structures and techniques are not shown in order to avoid unnecessarily obscuring the present invention.
References in the present application to "one embodiment," "an embodiment," "various embodiments," "an example," etc., indicate that the embodiment(s) or example(s) described may include a particular feature, structure, or characteristic, but every embodiment or example need not necessarily include the particular feature, structure, or characteristic. Moreover, repeated usage of the phrase "in one example" does not necessarily refer to the same example, although it may.
In order to improve the accuracy of transferring the clinical specimen detection obtained by using the operation curves when the bottle opening times of the reagents in the same batch are different, embodiments of the present invention provide an operation curve transfer method and apparatus that can confirm the reagent batch operation curve of the reagents in the same batch and the reagent bottle operation curve of any one of the reagents in the same batch in consideration of the bottle opening times of the reagents. The reagent batch working curve and the reagent bottle working curve are working curves. In one example, the working curve may be a curve with the known concentration of the standard sample on the abscissa and the signal value from the test of the unknown reagent at the known concentration on the standard sample of the known concentration on the ordinate. The reagent batch working curve can be transferred and used in the same batch of reagents. The reagent batch working curves of different batches of reagents cannot be used in mutual communication. For example, the same batch has 10 bottles of reagents, and the labels of the 10 bottles of reagents are a1 to a10, respectively, so that the working curves of the corresponding reagent batch of the batch can be transferred and used in the reagents a1 to a 10.
Fig. 1 is a flowchart of a method for transferring a working curve according to an embodiment of the present invention. As shown in fig. 1, the method for transferring the operation curve includes steps 101 to 103.
In step 101, the bottle opening time of the target bottle reagent is obtained, and whether the bottle opening time of the target bottle reagent exceeds a reagent characteristic safety time threshold value is detected.
Wherein, the target bottle reagent is one bottle of reagent in a plurality of bottles of reagents in the same batch. The decap time is the length of time that the reagent is first opened to the current time. The reagent itself can change over time and the change is sufficient to cause a differential change in the working curve. In the embodiment of the invention, whether the bottle opening time of the target bottle reagent exceeds the reagent characteristic safety time threshold value needs to be detected. The reagent characteristic safety time threshold is a limit for judging whether the working curve of the reagent can be subjected to differential change. Specifically, the reagent characteristic safety time threshold may be set according to experimental experience, work requirements, and the like, and is not limited herein. For example, the reagent characteristic safety time threshold may be set to 48 hours, i.e. the reagent changes greatly after the default 48 hours, so that the working curve obtained by calibration at this time changes differentially compared with the working curve within 48 hours of the bottle opening time.
In step 102, if the bottle opening time of the target bottle reagent exceeds the reagent characteristic safety time threshold, it is determined whether the reagent lot in which the target bottle reagent is located corresponds to the reagent lot working curve.
If the bottle opening time of the target bottle reagent exceeds the reagent characteristic safety time threshold, the working curve obtained by calibrating the target bottle reagent at the moment is shown to be changed in difference with the working curve of the same batch of reagents of which the bottle opening time does not exceed the reagent characteristic safety time threshold. Therefore, it is necessary to determine whether the reagent lot of the target vial corresponds to the reagent lot operating curve. The reagent batch working curve is a working curve which can be used by transferring the reagent in the same batch.
In step 103, if the reagent lot of the target bottle reagent corresponds to the reagent lot working curve, the reagent lot working curve corresponding to the reagent lot of the target bottle reagent is transferred to be used, and the working curve obtained by calibrating the target bottle reagent at present is only used as the reagent bottle working curve of the target bottle reagent.
Under the condition that the reagent in the same batch has a reagent batch working curve, the working curve obtained by calibrating the target bottle reagent with the bottle opening time exceeding the reagent characteristic safety time threshold is transmitted to other reagents with the bottle opening time not exceeding the reagent characteristic safety time threshold, so that the accuracy of the detection result is reduced. Therefore, under the condition that the reagent lot in which the target bottle reagent is located corresponds to the reagent lot working curve and the bottle opening time of the target bottle reagent exceeds the reagent characteristic safety time threshold, the reagent lot working curve of the reagent lot in which the target bottle reagent is located is adopted and transmitted and used as the latest reagent lot working curve of the reagent lot in which the target bottle reagent is located.
In the embodiment of the invention, the current calibration working curve of the reagent with the bottle opening time exceeding the safety time threshold of the reagent characteristic is avoided being used as the latest reagent batch working curve; namely, the working curve of the reagent with the difference change generated by the working curve compared with other reagents with the bottle opening time not exceeding the safety time threshold of the reagent characteristic is avoided to be used as the latest working curve of the reagent batch. Therefore, the transmission of the working curve which is not accurately used is avoided, the transmission accuracy of the reagent batch working curve is improved, and the accuracy of the detection result of the clinical specimen detection by using the transmitted reagent batch working curve is further improved.
Fig. 2 is a flowchart of a method for transferring an operation curve according to another embodiment of the present invention. Fig. 2 is different from fig. 1 in that the method for transferring the operation curve shown in fig. 2 may further include steps 104 to 109
In step 104, the target vial reagent is calibrated to determine whether the calibration of the target vial reagent was successful.
And calibrating the target bottle reagent, namely detecting the standard sample with known concentration by using the target bottle reagent, and acquiring a monitoring signal of the target bottle reagent on the standard sample with known concentration by using the probe. The working curve of the target bottle reagent can be obtained by detecting the standard sample with a plurality of different known concentrations. And if the working curve of the target bottle reagent can be obtained through fitting, and the deviation between the working curve of the target bottle reagent obtained through fitting and the main standard curve brought by the leaving factory of the target bottle reagent is within the acceptance range, the calibration of the target bottle reagent is considered to be successful. And if the working curve of the target bottle reagent is not obtained through fitting, or the deviation between the working curve of the target bottle reagent obtained through fitting and the main standard curve brought by the factory leaving of the target bottle reagent is out of the receiving range, determining that the calibration of the target bottle reagent fails.
In step 105, if the calibration of the target bottle reagent fails, it is determined whether the reagent lot in which the target bottle reagent is located corresponds to the reagent lot operating curve.
If the calibration of the target bottle reagent fails, the current working curve of the target bottle reagent cannot be obtained. However, if the working curve is required for the experimental detection, the experimental detection can be performed using the reagent lot working curve corresponding to the reagent lot in which the target bottle of reagent is located, and thus it can be determined whether or not the reagent lot in which the target bottle of reagent is located corresponds to the reagent lot working curve. The experimental detection comprises the detection of clinical specimens.
If the calibration of the target vial reagent is successful, the calibration can be used to obtain a working curve to participate in the execution of steps 101 to 103 in the above embodiment.
In step 106, if the reagent lot to which the target vial reagent belongs corresponds to the reagent lot operation curve, the reagent lot operation curve corresponding to the reagent lot to which the target vial reagent belongs is used as the operation curve of the target vial reagent.
And if the calibration of the target bottle reagent fails and the reagent batch of the target bottle reagent corresponds to the reagent batch working curve, taking the reagent batch working curve as the working curve of the target bottle reagent and using the reagent batch working curve. Since the reagent lot working curve is not calibrated according to the target vial reagent, it cannot be used as the reagent vial working curve of the target vial reagent. For example, when the target bottle reagent is used for the experimental detection, the reagent lot operation curve may be used as the operation curve of the target bottle reagent. That is, the transfer use of the reagent batch working curve in the reagent of the same batch is realized.
In step 107, if the reagent lot of the target bottle reagent does not correspond to the reagent lot working curve, the reagent in the reagent lot of the target bottle reagent is rejected from being used for the experimental detection.
And if the calibration of the target bottle reagent fails and the reagent batch where the target bottle reagent is located does not correspond to the reagent batch working curve, determining that the target bottle reagent has no usable reagent batch working curve and reagent bottle working curve. Even if the target bottle reagent and the reagent in the same batch with the target bottle reagent are used for experimental detection, an accurate detection result cannot be obtained. Therefore, the experimental tests were rejected using the reagents in the reagent lot in which the target vial of reagents was located. In one example, the target vial reagent may also be calibrated again until the calibration is successful.
In step 108, if the bottle opening time of the target bottle reagent does not exceed the reagent characteristic safety time threshold, the operation curve obtained by the current calibration of the target bottle reagent is used as the latest reagent lot operation curve of the reagent lot in which the target bottle reagent is located, and the operation curve obtained by the current calibration of the target bottle reagent is used as the latest reagent bottle operation curve of the target bottle reagent.
If the bottle opening time of the target bottle reagent does not exceed the reagent characteristic safety time threshold, the difference between the work curve obtained by the current calibration of the target bottle reagent and the work curve of the same batch of reagents does not change, so that the work curve obtained by the current calibration of the target bottle reagent can be used as the latest reagent batch work curve of the reagent batch in which the target bottle reagent is located and transferred for use.
The currently calibrated working curve of the target vial reagent in step 108 may also be used as the latest reagent vial working curve of the target vial reagent.
In step 109, if the reagent lot in which the target bottle reagent is located does not correspond to the reagent lot working curve, the working curve obtained by currently calibrating the target bottle reagent is used as the latest reagent bottle working curve of the target bottle reagent, and the working curve obtained by currently calibrating the target bottle reagent is used as the latest reagent lot working curve of the reagent lot in which the target bottle reagent is located.
And if the bottle opening time of the target bottle reagent exceeds the reagent characteristic safety time threshold and the reagent batch where the target bottle reagent is located does not correspond to the reagent batch working curve, taking the working curve obtained by current calibration of the target bottle reagent as the latest reagent bottle working curve of the target bottle reagent.
Although the decap time of the target vial reagent has exceeded the reagent characteristic safety time threshold, the difference between the target vial reagent whose decap time exceeds the reagent characteristic safety time threshold and other vial reagents of the same batch whose decap time does not exceed the reagent characteristic safety time threshold is also related to environmental, instrument, user usage habit, etc., and does not cause a difference change in consideration that the time during which the decap time exceeds the reagent characteristic safety time threshold may be short. And under the condition that the bottle opening time of the target bottle reagent exceeds the reagent characteristic safety time threshold and the reagent batch of the target bottle reagent does not correspond to the reagent batch working curve, transferring the working curve obtained by the current calibration of the target bottle reagent as the latest reagent batch working curve of the reagent batch for use. When clinical specimen detection is carried out, the reagent to be used is subjected to quality control every day, if the quality control does not pass, the reagent is subjected to recalibration, and the reagent batch working curve obtained above cannot be used for clinical specimen detection. However, if the quality control is passed, the clinical specimen detection can be performed using the reagent batch working curve obtained above. Thereby avoiding the need to calibrate all reagents in the reagent lot in which the target vial reagent is located in sequence, while being able to transfer the working curve of the reagent lot in use. The time spent on calibrating the reagent before clinical specimen detection and the cost generated by calibrating the reagent are reduced as much as possible.
This will be explained below by way of a specific example. Assume that the same batch of reagents has three bottles of reagents, a bottle of reagents, B bottle of reagents, and C bottle of reagents. The reagent property safety time threshold is 48 hours, i.e. two days. Table one shows the transfer process of the operation curves of the reagent bottles a, B and C using the transfer method of the operation curves in the example of the present invention.
Watch 1
The reagent in bottle A is used for the first time by opening the bottle at 1 month and 1 day, and the calibration is carried out at 1 month and 1 day to generate a working curve C1, wherein the working curve C1 is used as the reagent batch working curve of the reagent batch of the reagent and the reagent bottle working curve of the reagent in bottle A. The working curve C1 can be transferred to the B bottle reagent used for the first bottle opening in 1 month and 20 days to be used as the working curve of the reagent batch. Vial a of reagent was calibrated at 1 month and 15 days to give a working curve C2. Since the time for opening the a bottle of reagent exceeds two days at 15 days after 1 month, the working curve C2 cannot be used as the working curve of the reagent batch, but the working curve C2 is the working curve obtained by the latest calibration of the a bottle of reagent, and the working curve C2 can be used as the latest working curve of the reagent bottle of the a bottle.
Bottle B reagent was first used by decapping on 20 am 1 month, but not calibrated on 20 am 1 month. The B vial reagent can be tested experimentally using the transferred batch working curve on 1 month 20 am. The B vial was used again at 1 month 20 pm and was calibrated at 1 month 20 pm to obtain a working curve C3. Since the opening time of the B bottle reagent in afternoon of 1 month and 20 days does not exceed two days, the working curve C3 can be used as the latest reagent batch working curve of the reagent batch, and the working curve C3 can also be used as the latest reagent bottle working curve of the B bottle. The B vial was reused on day 1, 23 and was calibrated on day 1, 23 to obtain the working curve C4. However, since the time for opening the reagent bottle B exceeds two days in 23 days of 1 month, the operation curve C4 cannot be used as the operation curve of the reagent bottle batch of the reagent bottle, but the operation curve C4 is the operation curve obtained by the latest calibration of the reagent bottle B, and the operation curve C4 can be used as the latest operation curve of the reagent bottle B.
The C vial reagent was used first by decapping on day 1, 24, but was not calibrated on day 1, 24. The C bottle reagent can be tested by using the latest reagent batch working curve, namely the working curve C3, of the transferred batch of reagent.
If the working curve transfer method in the prior art is used for transferring the working curves of the reagent bottles A, B and C. Then vial a of reagent is reused at day 1 month and 15, and when the calibration and working curve C2 are obtained, the working curve C2 is transferred to the other vials of reagent as the latest batch working curve for that batch. For example, in the morning of 20 months and 1 month, the test is performed using the working curve C2 under the condition that the reagent in the bottle B is used for the first time and is not calibrated. Since the working curve C2 is obtained from the calibration after the decap time of the a vial reagent exceeds two days, it is not applicable to the other reagents in the batch. The experimental detection using the working curve C2 causes the accuracy of the detection result to decrease.
In the embodiment of the invention, the working curve C2 can be obtained after the bottle opening time exceeds two days and can not be used as the working curve of the reagent batch, so that the error of the working curve C2 in the experimental detection of other reagents in the batch is avoided, and the accuracy of the detection result is improved.
It should be noted that, on the basis that the bottle opening time exceeds the reagent characteristic safety time threshold, the latest reagent bottle operation curve of the target bottle reagent should adopt the operation curve obtained by currently calibrating the target bottle reagent, regardless of whether the reagent in the same batch as the target reagent bottle has the reagent batch operation curve. The working curve of the target vial reagent calibrated at this time is differentially changed from the working curve of the same batch of reagents at the time of opening the vial without exceeding the safety time threshold of the reagent characteristic. Therefore, in order to ensure the accuracy of the monitoring result of the detection using the target bottle reagent, the operation curve obtained by the current calibration of the target bottle reagent should be used as the latest reagent bottle operation curve of the target bottle reagent. For any one vial of reagent, the reagent vial work curve is used in preference to the reagent batch work curve.
Fig. 3 is a flowchart of a method for transferring an operation curve according to another embodiment of the present invention. Fig. 3 is different from fig. 1 in that the method for transferring the operating curve shown in fig. 3 may further include steps 110 to 114 (the steps 101 to 103, and the steps 105 to 109 are not shown in fig. 3).
In step 110, it is detected whether the target vial reagent has a reagent vial operating curve.
In one example, when a new reagent, i.e., a target bottle reagent, is put in a scene during the experimental detection, or the target bottle reagent is calibrated and fails to be calibrated, in order to ensure that a working curve ensuring the accuracy of the experimental detection can be used, it is necessary to detect whether the target bottle reagent has a reagent bottle working curve.
In step 111, if the target bottle reagent does not have the reagent bottle operating curve, it is determined whether the reagent lot in which the target bottle reagent is located corresponds to the reagent lot operating curve.
If the target bottle reagent does not have the reagent bottle working curve, the experimental detection can be performed by using the reagent batch working curve corresponding to the reagent batch of the transferred target bottle reagent. Therefore, it is necessary to determine whether the reagent lot of the target vial corresponds to the reagent lot operating curve.
In step 112, if the reagent lot to which the target bottle reagent belongs corresponds to the reagent lot operation curve, the reagent lot operation curve of the reagent lot to which the target bottle reagent belongs is used as the operation curve of the target bottle reagent.
In step 113, if the reagent lot of the target bottle reagent does not correspond to the reagent lot working curve, the reagent in the reagent lot of the target bottle reagent is rejected from being used for the experimental detection.
In step 114, if the target bottle reagent has the reagent bottle operating curve, the reagent bottle operating curve of the target bottle reagent is used for performing the experimental detection.
If the target bottle reagent has a reagent bottle operating curve and the reagent lot in which the target bottle reagent is located corresponds to the reagent lot operating curve, the reagent bottle operating curve of the target bottle reagent is selected for the experimental detection.
In the embodiment of the invention, when a new reagent is put in the experimental detection, a working curve which ensures high accuracy of the detection result can be selected to be used as the working curve of the new reagent, so that the accuracy of the detection result of the experimental detection of the new reagent is improved.
Fig. 4 is a schematic structural diagram of an operation curve transmission device 200 according to an embodiment of the present invention. As shown in fig. 4, the apparatus 200 for transferring an operation curve may include a first detecting module 201, a first determining module 202, and a first determining module 203.
The first detection module 201 is configured to obtain a bottle opening time of a target bottle of reagent, and detect whether the bottle opening time of the target bottle of reagent exceeds a reagent characteristic safety time threshold, where the target bottle of reagent is one bottle of reagents in multiple bottles of reagents of the same batch.
The first determining module 202 is configured to determine whether a reagent lot in which the target vial reagent is located corresponds to a reagent lot working curve if the vial opening time of the target vial reagent exceeds the reagent characteristic safety time threshold.
The first determining module 203 is configured to transfer the reagent batch working curve corresponding to the reagent batch in which the target bottle reagent is located for use if the reagent batch in which the target bottle reagent is located corresponds to the reagent batch working curve.
In the embodiment of the invention, whether the bottle opening time of the reagent exceeds the safety time threshold of the reagent characteristic is considered in the process of judging the reagent batch working curve of the same batch of reagent. And under the condition that the reagent batch of the target bottle reagent corresponds to the reagent batch working curve and the bottle opening time of the target bottle reagent exceeds the reagent characteristic safety time threshold, the reagent batch working curve of the reagent batch of the target bottle reagent is used as the latest reagent batch working curve of the reagent batch of the target bottle reagent. The current calibration working curve of the reagent with the bottle opening time exceeding the safety time threshold of the reagent characteristic is prevented from being used as the latest reagent batch working curve; namely, the working curve of the reagent with the difference change generated by the working curve compared with other reagents with the bottle opening time not exceeding the safety time threshold of the reagent characteristic is avoided to be used as the latest working curve of the reagent batch. Thereby avoiding transmitting and using inaccurate working curves, improving the accuracy of transmitting the reagent batch working curves, and improving the accuracy of the detection result of clinical specimen detection by using the reagent batch working curves
Fig. 5 is a schematic structural diagram of an operation curve transmission device 200 according to another embodiment of the present invention. Fig. 5 differs from fig. 4 in that the transfer device 200 of the operation curve shown in fig. 5 may further include a second determination module 204, a second detection module 205, a second judgment module 206, a third determination module 207, and a fourth determination module 208.
The second determining module 204 is configured to, if the bottle opening time of the target bottle reagent does not exceed the reagent characteristic safety time threshold, take the currently calibrated working curve of the target bottle reagent as the latest reagent batch working curve of the reagent batch in which the target bottle reagent is located and transfer the working curve for use; and using the current calibration working curve of the target bottle reagent as the latest reagent bottle working curve of the target bottle reagent.
A second detection module 205 configured to calibrate the target vial of reagent, determining whether the calibration of the target vial of reagent was successful;
a second determining module 206, configured to determine whether the reagent lot of the target bottle reagent corresponds to the reagent lot working curve if the calibration of the target bottle reagent fails;
a third determining module 207 configured to use the reagent batch working curve corresponding to the reagent batch in which the target bottle reagent is located as the working curve of the target bottle reagent if the reagent batch in which the target bottle reagent is located corresponds to the reagent batch working curve;
the fourth determining module 208 is configured to reject the experimental detection using the reagent in the reagent lot of the target bottle of reagent if the reagent lot of the target bottle of reagent does not correspond to the reagent lot working curve.
Fig. 6 is a schematic structural diagram of an operation curve transmission device 200 according to another embodiment of the present invention. Fig. 6 is different from fig. 5 in that the transfer device 200 of the operation curve shown in fig. 6 may further include a third detection module 209, a third judgment module 210, a fifth determination module 211, a sixth determination module 212, a seventh determination module 213, and an eighth determination module 214.
A third detection module 209 configured to detect whether the target vial reagent has a reagent vial operating curve;
a third determining module 210, configured to determine whether the reagent batch in which the target bottle reagent is located corresponds to the reagent batch working curve if the target bottle reagent does not have the reagent bottle working curve;
a fifth determining module 211, configured to use the reagent batch working curve of the reagent batch in which the target bottle reagent is located as the working curve of the target bottle reagent if the reagent batch in which the target bottle reagent is located corresponds to the reagent batch working curve;
the sixth determining module 212 is configured to refuse to perform the experiment detection using the reagent in the reagent lot of the target bottle reagent if the reagent lot of the target bottle reagent does not correspond to the reagent lot working curve.
A seventh determining module 213 configured to perform an experimental test using the reagent bottle operating curve of the target bottle reagent if the target bottle reagent has the reagent bottle operating curve.
The eighth determining module 214 is configured to select the reagent bottle working curve of the target bottle reagent for performing the experimental detection if the target bottle reagent has the reagent bottle working curve and the reagent batch in which the target bottle reagent is located corresponds to the reagent batch working curve.
The method and apparatus for transferring an operation curve according to the embodiment of the present invention described with reference to fig. 1 to 6 may be implemented by the apparatus 300 for transferring an operation curve. Fig. 7 is a schematic hardware configuration diagram of an operation curve transmission apparatus 300 according to an embodiment of the present invention.
The transfer device 300 of the working curve comprises a memory 301, a processor 302 and a computer program stored on the memory 301 and executable on the processor 302.
In one example, the processor 302 described above may include a Central Processing Unit (CPU), or A Specific Integrated Circuit (ASIC), or one or more integrated circuits that may be configured to implement embodiments of the present invention.
Memory 301 may include mass storage for data or instructions. By way of example, and not limitation, memory 301 may include a hard disk drive (i.e., HDD), a floppy disk drive, flash memory, an optical disk, a magneto-optical disk, magnetic tape, or a universal serial bus (i.e., USB) drive or a combination of two or more of these. Memory 301 may include removable or non-removable or fixed media, where appropriate. The memory 301 may be internal or external to the transfer device 300 of the operating curve, where appropriate. In a particular embodiment, the memory 301 is a non-volatile solid-state memory. In particular embodiments, memory 301 includes read only memory (i.e., ROM). Where appropriate, the ROM may be mask-programmed ROM, programmable ROM (i.e., PROM), erasable PROM (i.e., EPROM), electrically erasable PROM (i.e., EEPROM), electrically rewritable ROM (i.e., EAROM), or flash memory, or a combination of two or more of these.
The processor 302 runs a program corresponding to the executable program code by reading the executable program code stored in the memory 301, for executing the transfer method of the operation curve in the above-described embodiment.
In one example, the operational profile delivery device 300 may also include a communication interface 303 and a bus 304. As shown in fig. 7, the memory 301, the processor 302, and the communication interface 303 are connected via a bus 304 to complete communication therebetween.
The communication interface 303 is mainly used for implementing communication between modules, apparatuses, units and/or devices in the embodiment of the present invention. The communication interface 303 may also access input devices and/or output devices.
The bus 304 includes hardware, software, or both to couple the components of the operational curve passing device 300 to one another. By way of example, and not limitation, bus 304 may comprise an accelerated graphics port (i.e., AGP) or other graphics bus, an enhanced industry standard architecture (i.e., EISA) bus, a front-side bus (i.e., FSB), a hypertransport (i.e., HT) interconnect, an industry standard architecture (i.e., ISA) bus, an infiniband interconnect, a low pin count (i.e., LPC) bus, a memory bus, a micro channel architecture (i.e., MCA) bus, a peripheral component interconnect (i.e., PCI) bus, a PCI-Express (i.e., PCI-X) bus, a serial advanced technology attachment (i.e., SATA) bus, a video electronics standards association local (i.e., VLB) bus, or other suitable bus or a combination of two or more. Bus 304 may include one or more buses, where appropriate. Although specific buses have been described and shown in the embodiments of the invention, any suitable buses or interconnects are contemplated by the invention.
An embodiment of the present invention further provides a storage medium, where the storage medium stores a program, and the program, when executed by a processor, implements the method for transferring the working curve in the foregoing embodiment.
It should be clear that the embodiments in this specification are described in a progressive manner, and the same or similar parts in the embodiments are referred to each other, and each embodiment focuses on the differences from the other embodiments. For apparatus embodiments, device embodiments and storage medium embodiments, reference may be made to the description of the method embodiments for relevant points. The present invention is not limited to the specific steps and structures described above and shown in the drawings. Those skilled in the art may make various changes, modifications and additions or change the order between the steps after appreciating the spirit of the invention. Also, a detailed description of known process techniques is omitted herein for the sake of brevity.
Claims (8)
1. A method for transferring an operating curve, comprising:
obtaining the bottle opening time of a target bottle reagent, and detecting whether the bottle opening time of the target bottle reagent exceeds a reagent characteristic safety time threshold value or not, wherein the target bottle reagent is one bottle of reagents in a plurality of bottles of reagents in the same batch;
if the bottle opening time of the target bottle reagent exceeds the reagent characteristic safety time threshold, judging whether the reagent batch of the target bottle reagent corresponds to a reagent batch working curve;
if the reagent batch of the target bottle reagent corresponds to the reagent batch working curve, transferring the reagent batch working curve corresponding to the reagent batch of the target bottle reagent for use;
the method further comprises the following steps:
if the bottle opening time of the target bottle reagent does not exceed the reagent characteristic safety time threshold, taking a working curve obtained by current calibration of the target bottle reagent as a latest reagent batch working curve of the reagent batch where the target bottle reagent is located, and transferring the working curve for use;
and taking the working curve obtained by the current calibration of the target bottle reagent as the latest reagent bottle working curve of the target bottle reagent and using the working curve;
the method further comprises the following steps:
detecting whether the target bottle reagent has a reagent bottle working curve;
if the target bottle reagent has a reagent bottle working curve, performing experimental detection by using the reagent bottle working curve of the target bottle reagent;
if the target bottle reagent does not have the reagent bottle working curve, judging whether the reagent batch of the target bottle reagent corresponds to the reagent batch working curve;
if the reagent batch of the target bottle reagent corresponds to the reagent batch working curve, taking the reagent batch working curve of the reagent batch of the target bottle reagent as the working curve of the target bottle reagent and using the reagent batch working curve;
and if the reagent batch of the target bottle reagent does not correspond to the reagent batch working curve, refusing to use the reagent in the reagent batch of the target bottle reagent for experimental detection.
2. The method of claim 1, further comprising:
calibrating the target bottle reagent, and determining whether the calibration of the target bottle reagent is successful;
if the calibration of the target bottle reagent fails, judging whether a reagent batch in which the target bottle reagent is located corresponds to a reagent batch working curve;
if the reagent batch of the target bottle reagent corresponds to the reagent batch working curve, taking the reagent batch working curve corresponding to the reagent batch of the target bottle reagent as the working curve of the target bottle reagent and using the reagent batch working curve;
and if the reagent batch of the target bottle reagent does not correspond to the reagent batch working curve, refusing to use the reagent in the reagent batch of the target bottle reagent for experimental detection.
3. The method of claim 1 or 2, further comprising:
and if the target bottle reagent has a reagent bottle working curve and the reagent batch where the target bottle reagent is located corresponds to the reagent batch working curve, selecting the reagent bottle working curve of the target bottle reagent for carrying out experimental detection.
4. A device for transferring an operating curve, comprising:
the first detection module is configured to acquire the bottle opening time of a target bottle of reagent, and detect whether the bottle opening time of the target bottle of reagent exceeds a reagent characteristic safety time threshold, wherein the target bottle of reagent is one bottle of reagent in multiple bottles of reagents in the same batch;
the first judgment module is configured to judge whether a reagent batch in which the target bottle reagent is located corresponds to a reagent batch working curve or not if the bottle opening time of the target bottle reagent exceeds a reagent characteristic safety time threshold;
the first determination module is configured to transfer the reagent batch working curve corresponding to the reagent batch of the target bottle reagent for use if the reagent batch of the target bottle reagent corresponds to the reagent batch working curve;
the device further comprises:
the second determination module is configured to, if the bottle opening time of the target bottle reagent does not exceed the reagent characteristic safety time threshold, take the currently calibrated working curve of the target bottle reagent as the latest reagent batch working curve of the reagent batch where the target bottle reagent is located and transfer the working curve for use; and taking the working curve obtained by the current calibration of the target bottle reagent as the latest reagent bottle working curve of the target bottle reagent and using the working curve;
the device further comprises:
a third detection module configured to detect whether the target vial reagent has a reagent vial operating curve;
the third judging module is configured to judge whether a reagent batch in which the target bottle reagent is located corresponds to a reagent batch working curve if the target bottle reagent does not have the reagent bottle working curve;
a fifth determining module, configured to use the reagent batch working curve of the reagent batch in which the target bottle reagent is located as the working curve of the target bottle reagent if the reagent batch in which the target bottle reagent is located corresponds to the reagent batch working curve;
the sixth determining module is configured to refuse to perform experimental detection by using the reagent in the reagent batch of the target bottle reagent if the reagent batch of the target bottle reagent does not correspond to the reagent batch working curve;
a seventh determination module configured to perform an experimental test using the reagent bottle operating curve of the target bottle reagent if the target bottle reagent has the reagent bottle operating curve.
5. The apparatus of claim 4, further comprising:
a second detection module configured to calibrate the target vial of reagent, determining whether the calibration of the target vial of reagent was successful;
the second judgment module is configured to judge whether the reagent batch in which the target bottle reagent is located corresponds to a reagent batch working curve or not if the calibration of the target bottle reagent fails;
a third determining module, configured to, if the reagent batch in which the target bottle reagent is located corresponds to the reagent batch working curve, use the reagent batch working curve corresponding to the reagent batch in which the target bottle reagent is located as the working curve of the target bottle reagent;
and the fourth determination module is configured to refuse to perform experimental detection by using the reagent in the reagent batch of the target bottle reagent if the reagent batch of the target bottle reagent does not correspond to the reagent batch working curve.
6. The apparatus of claim 4 or 5, further comprising:
and the eighth determining module is configured to select the reagent bottle working curve of the target bottle reagent to perform experimental detection if the target bottle reagent has the reagent bottle working curve and the reagent batch where the target bottle reagent is located corresponds to the reagent batch working curve.
7. An operational curve transmission apparatus, comprising a memory, a processor, and a program stored in the memory and executable on the processor, wherein the processor executes the program to implement the operational curve transmission method according to any one of claims 1 to 3.
8. A storage medium, characterized in that the storage medium has stored thereon a program which, when executed by a processor, implements the transfer method of an operation curve according to any one of claims 1 to 3.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103048464A (en) * | 2012-10-17 | 2013-04-17 | 武汉生之源生物科技有限公司 | Neutrophile granulocyte gelatinase related lipid transport protein detection kit and preparation method thereof |
| CN103175964A (en) * | 2013-02-21 | 2013-06-26 | 武汉华美生物工程有限公司 | Neuron specific enolase content detection kit and preparation method thereof |
-
2017
- 2017-12-12 CN CN201711321411.0A patent/CN108053866B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103048464A (en) * | 2012-10-17 | 2013-04-17 | 武汉生之源生物科技有限公司 | Neutrophile granulocyte gelatinase related lipid transport protein detection kit and preparation method thereof |
| CN103175964A (en) * | 2013-02-21 | 2013-06-26 | 武汉华美生物工程有限公司 | Neuron specific enolase content detection kit and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| （"分析测试中测量不确定度及评定 第三部分分析测试中主要不确定度分量的评定";曹宏燕;《冶金分析》;20050331(第3期);第1-10节 * |
| "尿碘检测实验室的质量控制分析";孙亚维等;《中国卫生检验杂志》;20110430(第4期);第1-3节 * |
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