CN108051577A - A kind of animal blood component detection apparatus - Google Patents

A kind of animal blood component detection apparatus Download PDF

Info

Publication number
CN108051577A
CN108051577A CN201711270849.0A CN201711270849A CN108051577A CN 108051577 A CN108051577 A CN 108051577A CN 201711270849 A CN201711270849 A CN 201711270849A CN 108051577 A CN108051577 A CN 108051577A
Authority
CN
China
Prior art keywords
animal blood
hollow stem
telescopic rod
liquid storage
detection apparatus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN201711270849.0A
Other languages
Chinese (zh)
Other versions
CN108051577B (en
Inventor
不公告发明人
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shaanxi BMW Biotechnology Co., Ltd.
Original Assignee
Xuzhou Fruit Pose Agel Ecommerce Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xuzhou Fruit Pose Agel Ecommerce Ltd filed Critical Xuzhou Fruit Pose Agel Ecommerce Ltd
Priority to CN201711270849.0A priority Critical patent/CN108051577B/en
Publication of CN108051577A publication Critical patent/CN108051577A/en
Application granted granted Critical
Publication of CN108051577B publication Critical patent/CN108051577B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0017Filtration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2202/00Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
    • A61L2202/20Targets to be treated
    • A61L2202/22Blood or products thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

A kind of animal blood component detection apparatus of the present invention discloses animal blood composition detection sampler a kind of by being filtered sterilization to animal blood in extraction process, and that interim storage heating is carried out after extracting.The activity of animal blood sample liquid inner cell can be effectively improved, improves the accuracy of blood constituent detection data.It is characterized in that main body set is placed in hollow stem, the both ends of the main body set are connected respectively with hollow stem, liquid storage cylinder is equipped between the main body set and hollow stem, screw thread is equipped on the main body set inner wall, fluid hole there are two symmetrically being opened in the hollow stem, and it is connected respectively with liquid storage cylinder, the diameter of the fluid hole is gradually increased from import to outlet, inlet opening there are two symmetrically being opened in the hollow stem, and it is connected respectively with liquid storage cylinder, the inlet opening is located at the top of fluid hole, the inlet opening it is narrow into mouth width, outlet.

Description

A kind of animal blood component detection apparatus
Technical field
A kind of animal blood component detection apparatus of the present invention is related to and a kind of uses when being detected to animal blood ingredient Sampler belongs to field of food detection.It is more particularly to a kind of to be killed by being filtered in extraction process to animal blood Bacterium, and the animal blood composition detection sampler of interim storage heating is carried out after extracting.
Background technology
At present, animal blood is good for because iron-holder is higher, the micro- abundant and utilization that is easily absorbed by the body beneficial to human body Health is largely used as processing raw material, before being produced and processed, it usually needs the ingredient in animal blood is examined It surveys, to identify whether its quality complies with standard, when being detected, to being detected with a batch of fresh animal blood using sampling Method be sampled, when being sampled, traditional method is that a certain amount of animal blood is taken to be put into container, passes through gauze Etc. being filtered, the animal blood of acquisition is detected, is performed in this operating process, animal new blood increases with standing time Add, activity reduces haemocyte to the cold, the problem of solidification, affects for subsequent detection, detection data are not smart Really, effect is bad.
The content of the invention
In order to improve the above situation, a kind of animal blood component detection apparatus of the present invention provides one kind by decimated Sterilization is filtered in journey to animal blood, and the animal blood composition detection sampling of interim storage heating is carried out after extracting Device.The activity of animal blood sample liquid inner cell can be effectively improved, improves the accuracy of blood constituent detection data.
A kind of animal blood component detection apparatus of the present invention is realized in:A kind of animal blood composition detection of the present invention Device is made of agent set and sampler, and agent set is by inlet opening, main body set, hollow stem, liquid storage cylinder and fluid hole group Into main body set is placed in hollow stem, and the both ends of the main body set are connected respectively with hollow stem, the main body set and hollow stem Between be equipped with liquid storage cylinder, is equipped with screw thread on the main body set inner wall, is symmetrically opened in the hollow stem there are two fluid hole, and respectively Be connected with liquid storage cylinder, the diameter of the fluid hole is gradually increased from import to outlet, symmetrically opened in the hollow stem there are two Inlet opening, and being connected respectively with liquid storage cylinder, the inlet opening are located at the top of fluid hole, the inlet opening into mouth width, go out Mouth is narrow, and sampler is by thermal conductive network, heating wire, horn cover, filter screen, sterilizing layer, fixed cylinder, sealing piston, fixed spring, company Extension bar, telescopic rod, liquid outlet channel, conduit and spacing ring composition, telescopic rod one end is placed in hollow stem one end, during the other end is placed in Outside empty bar, the telescopic rod and two fluid holes are corresponding, and liquid outlet channel is provided on the telescopic rod, and the liquid outlet channel is Y Type structure is equipped with annular slab on the telescopic rod other end, and tube at one end is placed on the telescopic rod other end, and with liquid outlet channel phase Connection, spacing ring are placed on hollow stem inner wall, and positioned at the top of telescopic rod, connecting rod is placed in hollow stem, and one end passes through Spacing ring is connected with the telescopic rod other end, and sealing piston is placed on the connecting rod other end, put in the sealing piston there are two Sheet rubber, and it is corresponding with two inlet openings respectively, fixed spring is placed in connecting rod, and positioned at spacing ring and sealing piston Between, fixed cylinder is placed in the hollow stem other end, and the fixed cylinder is built-in with sterilizing layer, and the outer middle side part of horn cover is placed in fixed cylinder On, and be connected with fixed cylinder, filter screen is placed in horn cover, and thermal conductive network is placed in liquid storage cylinder, and the thermal conductive network is made of copper, Multiple heating wire are respectively placed in liquid storage cylinder.
In use, when being detected to animal blood ingredient, horn cover is put into animal blood first, then along Hollow stem pulls out telescopic rod, and telescopic rod drives sealing piston to move by connecting rod, and fixed spring is compressed, and then will be dynamic Object blood is pumped into horn cover, and the animal blood in horn cover enters after strainer filtering into fixed cylinder, then through fixation It is entered after stenlizing layer sterilizing in cylinder in hollow stem, and between sealing piston and fixed cylinder, when sealing piston is moved When moving to the lower section of two inlet openings, two inlet openings are no longer blocked by sealing piston, and then the animal blood in hollow stem leads to It crosses two inlet openings to enter in liquid storage cylinder, be stored, when a certain amount of animal blood of liquid storage cylinder memory storage, stopped drag Telescopic rod, the heating wire work in liquid storage cylinder, heats the blood in liquid storage cylinder, improves blood inner cell activity, heat conduction Net is transferred heat in the animal blood in liquid storage cylinder, animal blood heating effect is improved, when needing to carry out follow-up animal blood During liquid composition detection, continue to pull out telescopic rod, make liquid outlet channel on telescopic rod company corresponding with two fluid holes respectively It is logical, and then the animal blood in liquid storage cylinder is flowed by two fluid holes in liquid outlet channel, is then flowed out by conduit, after progress Continuous detection work;
The design that the diameter of the fluid hole is gradually increased from import to outlet, convenient for the animal blood outflow in fluid hole;
The design narrow into mouth width, outlet of the inlet opening, flows into inlet opening convenient for the animal blood in hollow stem, prevents hollow Animal blood in bar is excessive, it is impossible to flow into time in liquid storage cylinder;
The design of annular slab is equipped on the telescopic rod other end, can to telescopic rod carry out /V, prevent telescopic rod entirely into Enter into hollow stem, be not easy to the pulling to telescopic rod;
It is put in the sealing piston there are two sheet rubber, and can be improved to two with two corresponding designs of inlet opening respectively The sealing effect of a inlet opening;
The design that the thermal conductive network is made of copper, the heat conductivility of copper is preferable, can improve and animal blood in liquid storage cylinder is added The thermal efficiency;
The heating wire and thermal conductive network cooperation, to the design that the animal blood in liquid storage cylinder is heated, can keep animal blood The activity of liquid inner cell improves the accuracy of detection data;
The filter screen and stenlizing layer fitted seal piston and telescopic rod to the design that animal blood is extracted, can taken out Sterilization is filtered during taking to animal blood, improves the efficiency sampled during animal blood detection;
Reach by being filtered sterilization to animal blood in extraction process, and interim storage heating is carried out after extracting Purpose.
Advantageous effect.
First, it is simple in structure, it is convenient and practical.
The efficiency of blood sampling when animal blood composition detection the 2nd, can be effectively improved.
3rd, the activity of animal blood sample liquid inner cell can be effectively improved, improves the accuracy of blood constituent detection data.
Description of the drawings
Fig. 1 is a kind of structure diagram of animal blood component detection apparatus of the present invention.
In attached drawing
Wherein part is:Thermal conductive network(1), heating wire(2), inlet opening(3), horn cover(4), filter screen(5), sterilize layer(6)Gu Safety barrel(7), sealing piston(8), main body set(9), hollow stem(10), fixed spring(11), connecting rod(12), telescopic rod(13), Liquid outlet channel(14), conduit(15), liquid storage cylinder(16), fluid hole(17), spacing ring(18).
Specific embodiment:
A kind of animal blood component detection apparatus of the present invention, which is achieved in that in use, working as, examines animal blood ingredient During survey, first by horn cover(4)It is put into animal blood, then along hollow stem(10)Pull out telescopic rod(13), stretch Bar(13)Pass through connecting rod(12)Drive sealing piston(8)It is mobile, fixed spring(11)It is compressed, and then animal blood is pumped into Horn cover(4)It is interior, horn cover(4)Interior animal blood passes through strainer(5)Fixed cylinder is entered after filtering(7)It is interior, then through solid Safety barrel(7)Hollow stem is entered after interior stenlizing layer sterilizing(10)It is interior, and positioned at sealing piston(8)And fixed cylinder(7)It Between, work as sealing piston(8)It is moved to two inlet openings(3)Lower section when, two inlet openings(3)No longer by sealing piston(8)Envelope It is stifled, and then hollow stem(10)Interior animal blood passes through two inlet openings(3)Enter liquid storage cylinder(16)It is interior, it is stored, when Liquid storage cylinder(16)During a certain amount of animal blood of memory storage, telescopic rod is stopped drag(13), liquid storage cylinder(16)Interior heating wire(2) Work, to liquid storage cylinder(16)Interior blood is heated, and improves blood inner cell activity, thermal conductive network(1)Transfer heat to storage Sap cavity(16)In interior animal blood, animal blood heating effect is improved, when needing to carry out follow-up animal blood composition detection, Continue to pull out telescopic rod(13), make telescopic rod(13)On liquid outlet channel(14)Respectively with two fluid holes(17)It is corresponding Connection, and then liquid storage cylinder(16)Interior animal blood passes through two fluid holes(17)Flow into liquid outlet channel(14)It is interior, then pass through Conduit(15)Outflow, carries out subsequent detection work;
The fluid hole(17)Diameter from import to the design that gradually increases of outlet, convenient for fluid hole(17)Interior animal blood Outflow;
The inlet opening(3)Into mouth width, the narrow design in outlet, convenient for hollow stem(10)Interior animal blood flows into inlet opening (3), prevent hollow stem(10)Interior animal blood is excessive, it is impossible to flow into liquid storage cylinder in time(16)It is interior;
The telescopic rod(13)The design of annular slab is equipped on the other end, it can be to telescopic rod(13)/V is carried out, prevents from stretching Bar(13)Entirely enter hollow stem(10)It is interior, it is not easy to telescopic rod(13)Pulling;
The sealing piston(8)On put there are two sheet rubber, and respectively with two inlet openings(3)Corresponding design, Neng Gouti Height is to two inlet openings(3)Sealing effect;
The thermal conductive network(1)The design being made of copper, the heat conductivility of copper is preferable, can improve to liquid storage cylinder(16)Interior animal blood The efficiency of heating surface of liquid;
The heating wire(2)And thermal conductive network(1)Cooperation, to liquid storage cylinder(16)The design that interior animal blood is heated, can The activity of animal blood inner cell is kept, improves the accuracy of detection data;
The filter screen(5)With stenlizing layer fitted seal piston(8)And telescopic rod(13), set to what animal blood was extracted Meter can be filtered animal blood in extraction process sterilization, improve the efficiency sampled during animal blood detection;
Reach by being filtered sterilization to animal blood in extraction process, and interim storage heating is carried out after extracting Purpose.

Claims (9)

1. a kind of animal blood component detection apparatus, it is characterized in that:Be made of agent set and sampler, agent set by into Fluid apertures, main body set, hollow stem, liquid storage cylinder and fluid hole composition, main body set are placed in hollow stem, the both ends point of the main body set It is not connected with hollow stem, liquid storage cylinder is equipped between the main body set and hollow stem, is equipped with screw thread on the main body set inner wall, institute State and symmetrically opened in hollow stem there are two fluid hole, and be connected respectively with liquid storage cylinder, symmetrically opened in the hollow stem there are two into Fluid apertures, and being connected respectively with liquid storage cylinder, the inlet opening are located at the top of fluid hole, sampler by thermal conductive network, heating wire, Horn cover, filter screen, sterilizing layer, fixed cylinder, sealing piston, fixed spring, connecting rod, telescopic rod, liquid outlet channel, conduit and limit Position ring composition, telescopic rod one end are placed in hollow stem one end, and the other end is placed in outside hollow stem, the telescopic rod and two fluid holes It is corresponding, annular slab is equipped on the telescopic rod other end, tube at one end is placed on the telescopic rod other end, and with liquid outlet channel phase Connection, spacing ring are placed on hollow stem inner wall, and positioned at the top of telescopic rod, connecting rod is placed in hollow stem, and one end passes through Spacing ring is connected with the telescopic rod other end, and sealing piston is placed on the connecting rod other end, and fixed spring is placed in connecting rod, And between spacing ring and sealing piston, fixed cylinder is placed in the hollow stem other end, and the fixed cylinder is built-in with sterilizing layer, loudspeaker The outer middle side part of cover is placed in fixed cylinder, and is connected with fixed cylinder, and filter screen is placed in horn cover, and thermal conductive network is placed in liquid storage cylinder Interior, multiple heating wire are respectively placed in liquid storage cylinder.
A kind of 2. animal blood component detection apparatus according to claim 1, it is characterised in that the diameter of the fluid hole It is gradually increased from import to outlet.
A kind of 3. animal blood component detection apparatus according to claim 1, it is characterised in that the import of the inlet opening Width, outlet are narrow.
4. a kind of animal blood component detection apparatus according to claim 1, it is characterised in that be provided on the telescopic rod Liquid outlet channel, the liquid outlet channel are y-type structure.
5. a kind of animal blood component detection apparatus according to claim 1, it is characterised in that put in the sealing piston There are two sheet rubber, and it is corresponding with two inlet openings respectively.
6. a kind of animal blood component detection apparatus according to claim 1, it is characterised in that the thermal conductive network is by copper Into.
7. a kind of animal blood component detection apparatus according to claim 1, it is characterised in that the heating wire and heat conduction Net cooperation, heats the animal blood in liquid storage cylinder, can keep the activity of animal blood inner cell.
8. a kind of animal blood component detection apparatus according to claim 1, it is characterised in that the filter screen and sterilization Layer fitted seal piston and telescopic rod, extract animal blood.
9. a kind of animal blood component detection apparatus according to claim 1, it is characterised in that animal in extraction process Blood is filtered sterilization, and interim storage heating is carried out after extracting.
CN201711270849.0A 2017-12-05 2017-12-05 A kind of animal blood component detection apparatus Active CN108051577B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201711270849.0A CN108051577B (en) 2017-12-05 2017-12-05 A kind of animal blood component detection apparatus

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201711270849.0A CN108051577B (en) 2017-12-05 2017-12-05 A kind of animal blood component detection apparatus

Publications (2)

Publication Number Publication Date
CN108051577A true CN108051577A (en) 2018-05-18
CN108051577B CN108051577B (en) 2019-10-11

Family

ID=62122255

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201711270849.0A Active CN108051577B (en) 2017-12-05 2017-12-05 A kind of animal blood component detection apparatus

Country Status (1)

Country Link
CN (1) CN108051577B (en)

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU816458A1 (en) * 1979-04-23 1981-03-30 Научно-Исследовательский Институттранспланталогии И Искусственных Op-Ганов Triggering mechanism of thermal converter for artificial heart
CN86209213U (en) * 1986-11-19 1987-08-12 纪昂 Twenty-microlitre-specimen blood taking instrument
JP5872444B2 (en) * 2012-04-11 2016-03-01 株式会社昭和螺旋管製作所 Pressure detector
CN205101219U (en) * 2015-11-09 2016-03-23 中石化石油工程技术服务有限公司 Plunger pump, plunger pump fluid end and sealed combination valve thereof
CN105709309A (en) * 2016-01-06 2016-06-29 徐昊华 Intelligent safe injection syringe
CN205635633U (en) * 2016-05-26 2016-10-12 清远泰盛生物科技有限公司 A retort for preparation of blood cell albumen powder
CN206167485U (en) * 2016-07-29 2017-05-17 武汉仝干医疗科技股份有限公司 Trinity wool knitting yarn formula bioartificial liver on -line monitoring and integrative system of constant temperature heating

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU816458A1 (en) * 1979-04-23 1981-03-30 Научно-Исследовательский Институттранспланталогии И Искусственных Op-Ганов Triggering mechanism of thermal converter for artificial heart
CN86209213U (en) * 1986-11-19 1987-08-12 纪昂 Twenty-microlitre-specimen blood taking instrument
JP5872444B2 (en) * 2012-04-11 2016-03-01 株式会社昭和螺旋管製作所 Pressure detector
CN205101219U (en) * 2015-11-09 2016-03-23 中石化石油工程技术服务有限公司 Plunger pump, plunger pump fluid end and sealed combination valve thereof
CN105709309A (en) * 2016-01-06 2016-06-29 徐昊华 Intelligent safe injection syringe
CN205635633U (en) * 2016-05-26 2016-10-12 清远泰盛生物科技有限公司 A retort for preparation of blood cell albumen powder
CN206167485U (en) * 2016-07-29 2017-05-17 武汉仝干医疗科技股份有限公司 Trinity wool knitting yarn formula bioartificial liver on -line monitoring and integrative system of constant temperature heating

Also Published As

Publication number Publication date
CN108051577B (en) 2019-10-11

Similar Documents

Publication Publication Date Title
CN207481276U (en) A kind of Chinese medicine dreg squeezes filter device
CN208436479U (en) A kind of traditional Chinese medicine liquid fine filtering apparatus
CN108051577A (en) A kind of animal blood component detection apparatus
CN110478972A (en) A kind of food processing rapeseed oil High-cfficiency Filtration equipment
CN207899072U (en) A kind of tcm internal medicine traditional Chinese medicine filtration device
CN105363239A (en) Traditional Chinese medicine extraction device for detecting extraction rate in real time
CN208060224U (en) A kind of water quality detection collecting device
CN204654997U (en) A kind of saliva sample collection container
CN208210699U (en) A kind of agricultural drop irrigation device of Chinese medicine medicament extracting solution
CN208627362U (en) A kind of biological medicine rack for test tube
CN211326037U (en) High-efficient hypothermia device
CN208405168U (en) A kind of medical care bed faecal collecting device
CN108852840A (en) A kind of Chinese medicine ceramic medicine decoction device
CN205124624U (en) Extrusion press is used to goat
CN214821118U (en) Grass industry science extraction element
CN208595762U (en) A kind of Chinese medicinal granule drying equipment
CN209422661U (en) A kind of Self-body fat transplanting fat-cell acquisition screening syringe
CN207342249U (en) A kind of heavy dose traditional Chinese medicine extraction liquid preparing system
CN202699785U (en) Self-venting precise bag type infusion apparatus
CN209322884U (en) A kind of menses stem cell collection device
CN206043141U (en) A kind of raising petss case clean filtering device under water
CN208505724U (en) Clenbuterol hydrochloride pretreating device in a kind of tissue
CN215026156U (en) Plant herbal antibacterial ingredient extraction device
CN205107702U (en) Blood sampling device
CN203861591U (en) Chinese herbal medicine decocting and extruding all-in-one machine

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
TA01 Transfer of patent application right

Effective date of registration: 20190909

Address after: 721000 Qianyang County, Baoji, Shaanxi Province

Applicant after: Shaanxi BMW Biotechnology Co., Ltd.

Address before: 221008 Jiangsu province Xuzhou Quanshan avenue of science and technology science and technology building students Pioneering Park Room 207

Applicant before: Xuzhou fruit pose Agel Ecommerce Ltd

TA01 Transfer of patent application right
GR01 Patent grant
GR01 Patent grant