CN108037166A - A kind of glucagon test instrument - Google Patents
A kind of glucagon test instrument Download PDFInfo
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- CN108037166A CN108037166A CN201711264867.8A CN201711264867A CN108037166A CN 108037166 A CN108037166 A CN 108037166A CN 201711264867 A CN201711264867 A CN 201711264867A CN 108037166 A CN108037166 A CN 108037166A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
- G01N27/3273—Devices therefor, e.g. test element readers, circuitry
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- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
The present invention proposes a kind of glucagon test instrument, its glucagon test circuit includes enzyme electrode port Y, blood glucose signal conversion amplifying circuit, temperature observation circuit and MSP430 microcontrollers；Blood glucose signal conversion amplifying circuit includes resistance R2, R3, R4, R14, capacitance C8, C9, C21 and operational amplifier；R4, C9 and port Y connect operational amplifier end of oppisite phase, and R2, R3 and C8 connect operational amplifier in-phase end, and the R4 other ends, the C9 other ends and R14 connect operational amplifier output terminal；Microcontroller ADC module input port meets R14, and the R2 other ends connect microcontroller voltage stabilizing delivery outlet；Temperature observation circuit includes thermistor R9, resistance R10, capacitance C15 and voltage monitoring port；R9, R10 and C15 connect voltage monitoring port；The R9 other ends connect microcontroller voltage stabilizing delivery outlet.The advantage of the invention is that：Simple in structure, switch is few, stable, and response is rapid, and energy consumption is low；Influence of the reaction temperature to inspection result can be reduced to examining temperature to monitor in real time.
Description
Technical field
The present invention relates to a kind of medical inspection device, and in particular to a kind of glucagon test instrument.
Background technology
Glucagon test instrument is the common verifying attachment of hospital laboratory, coordinates glucagon test test paper to use, can be to blood
In blood sugar concentration be detected.At present, the glucagon test circuit structure of glucagon test instrument of the prior art is complicated, electronics member
Device and switch are numerous, its cost, energy consumption and maintenance cost are higher.Therefore, how to provide that a kind of structure is more simple, energy consumption
Lower glucagon test instrument, just solves the problems, such as into worth.
The content of the invention
The present invention is directed to above-mentioned technical problem, proposes a kind of glucagon test instrument, and be achieved through the following technical solutions.
The glucagon test instrument of the present invention, its glucagon test circuit include blood sugar test paper enzyme electrode connectivity port Y, blood glucose signal
Convert amplifying circuit, temperature observation circuit and MSP430 microcontrollers；
The blood glucose signal conversion amplifying circuit includes divider resistance R2, divider resistance R3, feedback amplification resistance R4, protective resistance
R14, electric capacity of voltage regulation C8, electric capacity of voltage regulation C9, filter capacitor C21 and operational amplifier；One end of R4, one end of C9 and blood glucose examination
The inverting input of paper enzyme electrode connectivity port Y while concatenation operation amplifier, one end of one end of R2, one end of R3 and C8
The in-phase input end of concatenation operation amplifier at the same time, one end concatenation operation at the same time of the other end of R4, the other end of C9 and R14
The output terminal of amplifier；One end of C21 and I/O mouthfuls of the input of MSP430 microcontroller ADC module connect the another of R14 at the same time
End, the other end of the other end of R3, the other end of C8 and C21 are grounded at the same time, the other end connection MSP430 Chip Microcomputer A/Ds C of R2
The voltage stabilizing delivery outlet of module；
The temperature observation circuit includes thermistor R9, high-precision resistance R10, electric capacity of voltage regulation C15 and voltage monitoring port；R9's
One end of one end, one end of R10 and C15 connects voltage monitoring port at the same time；The other end connection MSP430 Chip Microcomputer A/Ds C of R9
The voltage stabilizing delivery outlet of module, the other end of R10 and the other end of C15 are grounded at the same time.
The present invention can also be improved further by the following technical programs.
Preferably, the operational amplifier is LM358 operational amplifiers.
Preferably, the R9 is ET833 type thermistors.
Preferably, the value of described R2, R3, R4, R10, R14, C8, C9, C15 and C21 are respectively 120 kilo-ohms, 30,000
Europe, 60 kilo-ohms, 83 kilo-ohms, 50 Europe, 0.1 microfarad, 0.1 microfarad, 1000 pico farads and 1000 pico farads.
Preferably, the MSP430 microcontrollers are MSP430F249 microcontrollers；The MSP430 microcontrollers ADC module
I/O mouthfuls of input is the P6.5 pins of MSP430F249 microcontrollers, and the voltage stabilizing delivery outlet of the MSP430 microcontrollers ADC module is
The VREF pins of MSP430F249 microcontrollers, the voltage monitoring port are the P6.1 pins of MSP430F249 microcontrollers.
Preferably, the glucagon test instrument of the present invention further includes inspection data storage circuit, the inspection data storage electricity
Road includes 24LC64 chips, protective resistance R6, protective resistance R7 and electric capacity of voltage regulation C20；A0 pins, the A1 of 24LC64 chips draw
Foot, A2 pins and VSS pins are grounded, VCC pin, WP pins, SCL pins and the SDA pins difference of 24LC64 chips
Connect P4.0 pins, P4.1 pins, P4.2 pins and the P4.3 pins of MSP430F249 microcontrollers；MSP430F249 microcontrollers
P4.2 pins and P4.0 pins between connect R6, connect between the P4.3 pins and P4.0 pins of MSP430F249 microcontrollers
It is grounded after the P4.0 pin serial connections C20 of R7, MSP430F249 microcontroller.
Preferably, the value of described R6, R7 and C20 are respectively 5 kilo-ohms, 5 kilo-ohms and 0.1 microfarad.
Compared with prior art, the advantages and positive effects of the present invention are：
1st, simple in structure, response is rapid, can accurately and fast examine blood sugar concentration；
2nd, electronic switch is few, stable, energy consumption is low；
3rd, influence of the reaction temperature to inspection result can be reduced to examining temperature to monitor in real time；
4th, possess data storage function, a large amount of inspection datas can be stored, reliable contrasting foundation is provided for follow-up diagnosis and treatment.
Brief description of the drawings
Fig. 1 is the structure diagram of glucagon test instrument embodiment one of the present invention；
Fig. 2 is the structure diagram of glucagon test instrument embodiment two of the present invention.
Embodiment
In order to be better understood from the present invention, illustrate with reference to the accompanying drawings and examples.
Embodiment one：
As shown in Figure 1, the glucagon test circuit of the present embodiment glucagon test instrument includes blood sugar test paper enzyme electrode connectivity port Y, blood
Sugar signal conversion amplifying circuit, temperature observation circuit and MSP430 microcontrollers；
The blood glucose signal conversion amplifying circuit includes divider resistance R2, divider resistance R3, feedback amplification resistance R4, protective resistance
R14, electric capacity of voltage regulation C8, electric capacity of voltage regulation C9, filter capacitor C21 and operational amplifier；One end of R4, one end of C9 and blood glucose examination
The inverting input of paper enzyme electrode connectivity port Y while concatenation operation amplifier, one end of one end of R2, one end of R3 and C8
The in-phase input end of concatenation operation amplifier at the same time, one end concatenation operation at the same time of the other end of R4, the other end of C9 and R14
The output terminal of amplifier；One end of C21 and I/O mouthfuls of the input of MSP430 microcontroller ADC module connect the another of R14 at the same time
End, the other end of the other end of R3, the other end of C8 and C21 are grounded at the same time, the other end connection MSP430 Chip Microcomputer A/Ds C of R2
The voltage stabilizing delivery outlet of module；
The temperature observation circuit includes thermistor R9, high-precision resistance R10, electric capacity of voltage regulation C15 and voltage monitoring port；R9's
One end of one end, one end of R10 and C15 connects voltage monitoring port at the same time；The other end connection MSP430 Chip Microcomputer A/Ds C of R9
The voltage stabilizing delivery outlet of module, the other end of R10 and the other end of C15 are grounded at the same time.
Preferably, the operational amplifier is LM358 operational amplifiers of the prior art.
Preferably, the R9 is ET833 types thermistor of the prior art.
Preferably, the value of described R2, R3, R4, R10, R14, C8, C9, C15 and C21 are respectively 120 kilo-ohms, 30,000
Europe, 60 kilo-ohms, 83 kilo-ohms, 50 Europe, 0.1 microfarad, 0.1 microfarad, 1000 pico farads and 1000 pico farads.
Preferably, the MSP430 microcontrollers are MSP430F249 microcontrollers of the prior art；The MSP430 is mono-
I/O mouthfuls of the input of piece machine ADC module is the P6.5 pins of MSP430F249 microcontrollers, the MSP430 microcontrollers ADC module
Voltage stabilizing delivery outlet is the VREF pins of MSP430F249 microcontrollers, and the voltage monitoring port is MSP430F249 microcontrollers
P6.1 pins.
When examining blood glucose, by the blood sugar test paper enzyme electrode connectivity port Y of the present embodiment glucagon test instrument and in the prior art
Blood sugar test paper enzyme electrode connection, MSP430F249 microcontrollers VREF pins output 1.5V voltage stabilizings through R2 and R3 partial pressures
The driving voltage of 300mV is produced afterwards, which is applied to enzyme electrode both ends through operational amplifier；Instilled at enzyme electrode both ends
Blood to be tested, there are free electron in blood, under driving voltage effect, produces the orientation of μ A ranks between enzyme electrode both ends
Electric current, the directional current are directly proportional to the blood glucose concentration value in blood；The directional current turns through blood glucose signal conversion amplifying circuit
Changing voltage signal into and be amplified, amplified voltage signal inputs MSP430F249 microcontrollers through P6.5 pins,
The voltage signal received is converted into digital signal by the ADC module of MSP430F249 microcontrollers.
R4 plays the role of feedback amplification, and the output area of operational amplifier is limited to MSP430 Chip Microcomputer A/D C moulds by it
In the conversion range of block.
C21 plays a filtering role voltage signal, to reduce influence of the external interference to blood sugar test, it is ensured that the standard of measured value
Really.
R14 plays the role of isolating operational amplifier and capacitance, reduces operational amplifier and directly connects caused by capacitive load
Output concussion.Voltage signal can be influenced and changed by the pressure drop of R14 both ends, in order not to influence the precision of glucagon test, R14's
Resistance value should not be too large, and be preferably 50 Europe.
Since glucagon test is reacted using bioelectrochemistry, temperature is an important factor for influencing the reaction, different
At a temperature of, the activity of glucose oxidase is different；Even the blood of identical blood sugar concentration, using identical driving voltage,
Under different temperatures, the size of current produced by glucose oxidase is also different；When too high or too low for temperature, grape glycosyloxy
Changing enzyme will lose activity completely.Therefore, it is necessary to by temperature observation circuit to examining temperature to be monitored.
R9 is preferably ET833 thermistors, which has negative temperature characteristic.By the ginseng of MSP430 microcontroller ADC module
The 1.5V voltage stabilizings of voltage, the i.e. output of MSP430 microcontrollers ADC module voltage stabilizing delivery outlet are examined, R9 upper ends is connected on, ADC moulds can be eliminated
The caused transformed error of block reference voltage shake.By measuring the voltage of MSP430F249 microcontroller P6.1 pins, calculate
The size of thermistor R9, then according to the special type curve of ET833, you can extrapolate temperature value.
Embodiment two：
As shown in Fig. 2, the difference between this embodiment and the first embodiment lies in：The glucagon test instrument of the present embodiment further includes inspection data
Storage circuit, the inspection data storage circuit include 24LC64 chips, protective resistance R6, protective resistance R7 and electric capacity of voltage regulation
C20；A0 pins, A1 pins, A2 pins and the VSS pins of 24LC64 chips are grounded, VCC pin, the WP of 24LC64 chips
Pin, SCL pins and SDA pins connect respectively the P4.0 pins, P4.1 pins, P4.2 pins of MSP430F249 microcontrollers with
And P4.3 pins；Connect R6 between the P4.2 pins of MSP430F249 microcontrollers and P4.0 pins, MSP430F249 microcontrollers
Connect R7 between P4.3 pins and P4.0 pins, is grounded after the P4.0 pin serial connections C20 of MSP430F249 microcontrollers.
Preferably, the value of described R6, R7 and C20 are respectively 5 kilo-ohms, 5 kilo-ohms and 0.1 microfarad.
In order to record the glucagon test data of patient in case whens follow-up diagnosis and treatment contrasts, the glucagon test instrument of the present embodiment can be with
It is equipped with inspection data storage circuit.24LC64 chips have 8KB memory spaces, store the glucagon test number of more than 1000 enough
According to.
P4.0~P4.3 is digital I/O mouthfuls of MSP430F249 microcontrollers.P4.1 is write-protect pin, for avoid by
In the mistake write operation that external disturbance or program malfunction to 24LC64 chips.P4.2 pins and P4.3 pins be 24LC64 chips and
Communication serial port between MSP430F249 microcontrollers.P4.0 pins are used for 24LC64 chip power supplies, using I/O mouthfuls to 24LC64
Chip power supply, can not only reduce overall power, additionally it is possible to save electronic switch, reduce cost, and be conducive to connect up.
The above described is only a preferred embodiment of the present invention, being not the limitation for making other forms to the present invention, appoint
What those skilled in the art changed or be modified as possibly also with the technology contents of the disclosure above equivalent variations etc.
Effect embodiment is applied to other fields, but every without departing from technical solution of the present invention content, the technical spirit according to the present invention
Any simple modification, equivalent variations and the remodeling made to above example, still fall within the protection domain of technical solution of the present invention.
Claims (7)
- A kind of 1. glucagon test instrument, it is characterised in that：Its glucagon test circuit includes blood sugar test paper enzyme electrode connectivity port Y, blood Sugar signal conversion amplifying circuit, temperature observation circuit and MSP430 microcontrollers；The blood glucose signal conversion amplifying circuit includes divider resistance R2, divider resistance R3, feedback amplification resistance R4, protective resistance R14, electric capacity of voltage regulation C8, electric capacity of voltage regulation C9, filter capacitor C21 and operational amplifier；One end of R4, one end of C9 and blood glucose examination The inverting input of paper enzyme electrode connectivity port Y while concatenation operation amplifier, one end of one end of R2, one end of R3 and C8 The in-phase input end of concatenation operation amplifier at the same time, one end concatenation operation at the same time of the other end of R4, the other end of C9 and R14 The output terminal of amplifier；One end of C21 and I/O mouthfuls of the input of MSP430 microcontroller ADC module connect the another of R14 at the same time End, the other end of the other end of R3, the other end of C8 and C21 are grounded at the same time, the other end connection MSP430 Chip Microcomputer A/Ds C of R2 The voltage stabilizing delivery outlet of module；The temperature observation circuit includes thermistor R9, high-precision resistance R10, electric capacity of voltage regulation C15 and voltage monitoring port；R9's One end of one end, one end of R10 and C15 connects voltage monitoring port at the same time；The other end connection MSP430 Chip Microcomputer A/Ds C of R9 The voltage stabilizing delivery outlet of module, the other end of R10 and the other end of C15 are grounded at the same time.
- 2. glucagon test instrument according to claim 1, it is characterised in that：The operational amplifier is LM358 operation amplifiers Device.
- 3. glucagon test instrument according to claim 2, it is characterised in that：The R9 is ET833 type thermistors.
- 4. glucagon test instrument according to claim 1, it is characterised in that：Described R2, R3, R4, R10, R14, C8, C9, C15 And the value of C21 is respectively 120 kilo-ohms, 30 kilo-ohms, 60 kilo-ohms, 83 kilo-ohms, 50 Europe, 0.1 microfarad, 0.1 microfarad, 1000 pico farads and 1000 pico farads.
- 5. the glucagon test instrument according to claim 1 ~ 4, it is characterised in that：The MSP430 microcontrollers are MSP430F249 Microcontroller；I/O mouthfuls of the input of the MSP430 microcontrollers ADC module is the P6.5 pins of MSP430F249 microcontrollers, described The voltage stabilizing delivery outlet of MSP430 microcontroller ADC module be MSP430F249 microcontrollers VREF pins, the voltage monitoring port For the P6.1 pins of MSP430F249 microcontrollers.
- 6. glucagon test instrument according to claim 5, it is characterised in that：Further include inspection data storage circuit, the inspection Testing data storage circuitry includes 24LC64 chips, protective resistance R6, protective resistance R7 and electric capacity of voltage regulation C20；24LC64 chips A0 pins, A1 pins, A2 pins and VSS pins be grounded, the VCC pins of 24LC64 chips, WP pins, SCL pins with And SDA pins connect P4.0 pins, P4.1 pins, P4.2 pins and the P4.3 pins of MSP430F249 microcontrollers respectively； Connect R6 between the P4.2 pins of MSP430F249 microcontrollers and P4.0 pins, the P4.3 pins of MSP430F249 microcontrollers with Connect R7 between P4.0 pins, is grounded after the P4.0 pin serial connections C20 of MSP430F249 microcontrollers.
- 7. glucagon test instrument according to claim 6, it is characterised in that：The value of described R6, R7 and C20 are respectively 5,000 Europe, 5 kilo-ohms and 0.1 microfarad.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711264867.8A CN108037166A (en) | 2017-12-05 | 2017-12-05 | A kind of glucagon test instrument |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711264867.8A CN108037166A (en) | 2017-12-05 | 2017-12-05 | A kind of glucagon test instrument |
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| CN108037166A true CN108037166A (en) | 2018-05-15 |
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| CN201711264867.8A Pending CN108037166A (en) | 2017-12-05 | 2017-12-05 | A kind of glucagon test instrument |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102297709A (en) * | 2011-05-19 | 2011-12-28 | 常州大学 | Wireless industrial flow transducer |
| CN204129004U (en) * | 2014-10-23 | 2015-01-28 | 徐建民 | Intelligent blood sugar monitor |
| US9147144B2 (en) * | 2012-09-28 | 2015-09-29 | General Electric Company | Systems and methods for monitoring sensors |
| CN105184111A (en) * | 2015-11-06 | 2015-12-23 | 李良 | Fault identification system for direct current transmission line |
| CN106855576A (en) * | 2015-12-09 | 2017-06-16 | 江苏天正电气有限公司 | A kind of portable glucose meter |
-
2017
- 2017-12-05 CN CN201711264867.8A patent/CN108037166A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102297709A (en) * | 2011-05-19 | 2011-12-28 | 常州大学 | Wireless industrial flow transducer |
| US9147144B2 (en) * | 2012-09-28 | 2015-09-29 | General Electric Company | Systems and methods for monitoring sensors |
| CN204129004U (en) * | 2014-10-23 | 2015-01-28 | 徐建民 | Intelligent blood sugar monitor |
| CN105184111A (en) * | 2015-11-06 | 2015-12-23 | 李良 | Fault identification system for direct current transmission line |
| CN106855576A (en) * | 2015-12-09 | 2017-06-16 | 江苏天正电气有限公司 | A kind of portable glucose meter |
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Application publication date: 20180515 |