CN108020531A - It is a kind of to carry out dopamine and Al using fluorescent carbon point3+Detection method - Google Patents
It is a kind of to carry out dopamine and Al using fluorescent carbon point3+Detection method Download PDFInfo
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- CN108020531A CN108020531A CN201610959134.5A CN201610959134A CN108020531A CN 108020531 A CN108020531 A CN 108020531A CN 201610959134 A CN201610959134 A CN 201610959134A CN 108020531 A CN108020531 A CN 108020531A
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
- G01N2021/6432—Quenching
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Abstract
It is a kind of to carry out dopamine and Al using carbon quantum dot3+Detection method, include the following steps：1. with citric acid and 4,7,10 three oxygen, 1,13 tridecyl amine is as raw material, the fluorescent carbon point CNDs obtained by one step hydro thermal method；2. utilize detections of the fluorescent carbon point CNDs to dopamine-sensitive, selectivity and concentration；3. using fluorescent carbon point CNDs to Al3+The detection of sensitiveness, selectivity and concentration；4. the test influenced into the concentration of trip temperature, pH value, standing time and carbon dots on fluorescent carbon point fluorescence intensity；5. structure one kind is with dopamine and Al3+Based on logic gate.Present invention improves over existing method toxicity height, poor biocompatibility, water-soluble bad and the shortcomings that can only detect a kind of material, realizes using fluorescent carbon point to dopamine and Al3+Double check, and utilize this property carry out logic gate construction.
Description
Technical field：
The invention belongs to carry out dopamine and Al using carbon quantum dot in chemical field3+Detection, and bio-imaging and
The application of gate operation.
Background technology：
Biology, industry and environmentology have been widely used in for the hypersensitivity probe of target molecule and ion
Process, has been increasingly becoming important field of research.For example, it is because dopamine that dopamine probe, which is an important field of research,
It is to be discharged by nerve cell for sending signal to other nerve cells.But abnormal horizontal DOPA in the brain
Amine is associated with some diseases, such as Parkinson's and senile dementia.On the other hand, as Al3+Such metal ion
In many vital movements, such as in terms of the trace element of human body, the vital role of performer.It is many to study table
Bright, excessive Al3+Intake can cause renal failure, osteoporosis and neurological disorder.Therefore, dopamine and Al are detected3+
It is vital in terms of controlling the concentration in organism and environmental system.Up to the present, including liquid chromatography, chemistry are sent out
A variety of methods such as light, Capillary Electrophoresis and fluorescent technique have been used for the measure of dopamine.It is however, big in these methods
Majority can all be subject to the time to grow, and spend limitation that is high and needing complicated instrument.Such as to Al3+Detection, traditional detection
Method is all costly, complicated and inconvenient as flame atomic absorption method, inductively coupled plasma atomic emission spectrometry etc.
Quickly online sensing.
Fluorescence probe has been widely used in detection pollutant as a kind of effective instrument.Fluorescence probe can produce
Raw obvious signal intensity is used for the qualitative and quantitative analysis of material.According to the quantum dot (QDs) of semiconductor fabrication by with
Make a kind of strong fluorescence probe.But potential high toxicity and bad biocompatibility limit the wider of them
Using.The noncrystal carbon nano dot (CNDs) of fluorescence, another nano particle, there is good superior property, such as very high water
Dissolubility, very strong chemical inertness, is easier to carry out functionalization and good biocompatibility.Therefore, this carbon dots
(CNDs) in terms of being mainly used in bio-imaging, photoelectric device, medical diagnosis, photocatalysis and sensor.However, these methods
In most of be all only capable of detecting a kind of material.It is published on detection dopamine and Al3+This fluorescence probe almost
No.
The content of the invention：
The object of the present invention is to provide a kind of dopamine and Al are carried out using fluorescent carbon point3+Detection method, this method changes
Into existing method toxicity height, poor biocompatibility, water-soluble bad and the shortcomings that a kind of material can only be detected, profit is realized
With fluorescent carbon point to dopamine and Al3+Double check, and utilize this property carry out logic gate construction.
As above conceive, the technical scheme is that：It is a kind of to carry out dopamine and Al using carbon quantum dot3+Detection side
Method, it is characterised in that：Include the following steps：
1. with citric acid and 4,7,10- tri- oxygen -1,13- tridecyl amines are obtained glimmering as raw material by one step hydro thermal method
Light carbon dots CNDs；
2. utilize detections of the fluorescent carbon point CNDs to dopamine-sensitive, selectivity and concentration：
A, dopamine is added gradually in fluorescent carbon point solution according to concentration from 0 μM -200 μM, fluorescence intensity
Linear relationship between the dopamine between 20 μM -80 μM and fluorescent quenching efficiency F0/F -1 of change and concentration, as a result table
It is bright as the addition of dopamine, fluorescence intensity gradually decrease, illustrate this carbon dots for dopamine sensitiveness very well and have
There is 0.0078 μM of very low test limit；
B, influence tests of the fluorescent carbon point CNDs to fluorescent quenching is carried out：It is point-to-points to test the carbon for showing to be used in the present invention
Bar amine is selectively fine；
3. using fluorescent carbon point CNDs to Al3+The detection of sensitiveness, selectivity and concentration：
A, concentration is gradually added into the carbon dots solution of the dopamine containing 1mM from 0 μM -200 μM of Al3+It was observed that fluorescence
Intensity is significantly raised, designates CNDs- dopamine systems to Al3+Sensitiveness it is fine；
B, by fluorescence intensity and Al3+Relation data between concentration, wherein Al3+Concentration c scope 4 μM -40 μM it
Between, equation F0/F-1=-0.0058-0.0069c, wherein F0 are obtained not contain Al3+When fluorescence intensity, F Al3+Concentration
For c when fluorescence intensity, related coefficient 0.9928.Detection is limited to 0.0329 μM；
C, the carbon dots solution without dopamine is carried out to Al3+Sensitivity tests；
D, fluorescent carbon point is carried out to Al3+Selectivity test, the results show Al3+Fluorescence intensity is influenced maximum；
4. the test influenced into the concentration of trip temperature, pH value, standing time and carbon dots on fluorescent carbon point fluorescence intensity；
5. structure one kind is with dopamine and Al3+Based on logic gate:
Input signal：Contain dopamine or Al3+, it is worth for 1, is otherwise 0 output signal：Fluorescence recovers, and is worth for 1, fluorescence
Quenching value is 0 (excitation wavelength 423nm)
Only carbon dots when, dopamine=0Al3+=0 has fluorescence=1
In carbon dots dopamine system, dopamine=1Al3+=0 fluorescent quenching=0
Carbon dots and Al3+Dopamine=0Al in system3+=1 has fluorescence=1
Carbon dots dopamine, Al3+Dopamine=1Al in system3+=1 fluorescence recovers=1.
The present invention operation principle be：
1st, electronics transfer occurs after being combined using this fluorescent carbon point CNDs and dopamine causes the fluorescence of fluorescent carbon point
Quenching mechanism realizes the detection to dopamine.By can obtain equation to the data of different dopamine concentration and fluorescence intensity
F0/F-1=0.2328+0.0979c, wherein F0 are fluorescence intensity when being added without dopamine, and F is when dopamine concentration is c
Fluorescence intensity, related coefficient 0.9943.Dopamine concentration scope is at 20 μM to 80 μM.So as to extrapolate the inspection for dopamine
Survey is limited to 0.0078 μM.
2nd, using the carbon dots and the conjugate of dopamine in above-mentioned, CNDs- dopamines, are realized to Al3+Detection.Detection
Mechanism is：Al is added in CNDs- dopamines3+Afterwards, Al3+It can be combined with dopamine, so that having discharged has fluorescence
The CNDs of property, causes the recovery of fluorescence, and then the change of fluorescence intensity can be utilized to realize to Al3+Detection.By to glimmering
Luminous intensity and Al3+Relation data between concentration, obtains equation F0/F-1=-0.0058-0.0069c, wherein F0 not contain
Al3+When fluorescence intensity, F Al3+Fluorescence intensity when concentration is c, related coefficient 0.9928.Detection is limited to 0.0329 μM.
3rd, using above-mentioned property, one kind is constructed with dopamine and Al3+Based on logic gate, pass through dopamine and Al3+
Control to exporting signal is realized to the influence of fluorescence intensity.
The present invention has made intensive studies the disturbing factor in above-mentioned detection process, including temperature, pH value, when stablizing
Between and influence of the ionic strength to carbon dots fluorescence intensity.Interference test is carried out in phosphate buffer solution.Test knot
Fruit shows that temperature has little to no effect fluorescence intensity, in the test of pH value it was found that pH value be 7.0 when have most
High fluorescent emission intensity, the environment in this pH value and organism is much like, can be in biology this demonstrate this carbon dots
Apply in field.Stabilization time test result is shown：This carbon dots still remains very strong glimmering after exposing 30 days in atmosphere
Luminous intensity.Ionic strength test display：Also very little, this this carbon dots of explanation can carry out in practice for influences of the KCl to result
Application well.
Brief description of the drawings:
Detections of the fluorescent carbon point CNDs to the Study of Sensitivity and concentration of dopamine in Fig. 1 (a) present invention；Abscissa is
Wavelength (nm), ordinate is fluorescence intensity, (b) fluorescent carbon point CNDs is to the selectivity test figure of dopamine.
Carbon dots CNDs in Fig. 2 (a) (b) present invention is to Al3+Study of Sensitivity and the detection of concentration, (c) be free of DOPA
The carbon dots of amine is to Al3+Sensitivity tests, (d) carbon dots CNDs is to Al3+The test of selectivity.
The test that Fig. 3 temperature, pH value, the concentration of standing time and carbon dots CNDs influence fluorescence intensity.
The principle schematic of carbon dots CNDs construction logic doors in Fig. 4 present invention.
Embodiment：
Referring to the drawings 1-4, the present invention is described further：
It is a kind of to carry out dopamine and Al using fluorescent carbon point3+Detection method, include the following steps：
1st, obtained with citric acid and 4,7,10- tri- oxygen -1,13- tridecyl amines as raw material by one step hydro thermal method glimmering
Light carbon dots CNDs；
2nd, using detections of the fluorescent carbon point CNDs to dopamine-sensitive, selectivity and concentration.
(a) dopamine is added gradually in carbon dots solution according to concentration from 0 μM of 200 μM of to, fluorescence intensity
Linear relationship between change and different dopamine concentrations (20 μM to 80 μM) and fluorescent quenching efficiency F0/F -1.The result shows that
With the addition of dopamine, fluorescence intensity gradually decreases, and illustrates that this carbon dots is fine for the sensitiveness of dopamine and has
0.0078 μM of very low test limit.
(b) influence control of the different material to fluorescent quenching.A. blank sample B. catechols C. hydroquinones D. isophthalic
The diphenol E. bisphenols carbon dots that F.5- test of methyl -3- benzenediols G. dopamines shows to use in the present invention is to dopamine selectivity
Very well
3rd, using fluorescent carbon point CNDs to Al3+The detection of sensitiveness, selectivity and concentration.
(a) it is gradually added into Al in the carbon dots solution of the dopamine containing 1mM3+(concentration is from 0 μM to 200 μM) is observed glimmering
Luminous intensity is significantly raised, designates CNDs- dopamine systems to Al3+Sensitiveness it is fine.
(b) fluorescent quenching efficiency and Al3+The linear relationship of concentration, wherein Al3+Concentration range is between 4 μM of 40 μM of to
Meet good linear relationship.Extrapolate with 0.0329 μM relatively low of test limit.
(c) carbon dots solution without dopamine is to Al3+Sensitivity tests.The results show is free of the carbon dots pair of dopamine
Al3+Sensitiveness it is very poor, fluorescence intensity change very little.
(d) carbon dots is to Al3+Selectivity test.The change of fluorescence intensity is observed by adding different metal ions.Wherein
1:CNDs- dopamine 2s:Co2+；3:Ba2+；4:Zn2+；5:Ce3+；6:Al3+；7:Ni2+；8:Cr3+；9:Hg2+；10:Mn2
+；11:Cu2+；12:Ag+；13:La3+；14:Na+；15:Ca2+；16:Mg2+；17:Pb2+；18:K+；19:Pd2+；20:Fe3
+；21:Cd2+. the results show Al3+Maximum is influenced on fluorescence intensity, indicates this carbon dots to Al3+There is good selectivity.
4th, the test influenced into the concentration of trip temperature, pH value, standing time and carbon dots on fluorescence intensity.
(a) relation between different temperatures and fluorescence intensity shows, temperature influences very little to fluorescence intensity.
(b) relation curve of pH value and fluorescence intensity shows：Fluorescence intensity highest when pH is 7, due to organism
The pH value of interior environment is about 7 or so, it is possible to is applied using this property in biological field.
(c) time illustrates with fluorescence intensity change curve：What fluorescence intensity declined within 30 days is seldom, still keeps
Higher fluorescence intensity
(d) relation curve of different KCl concentration and fluorescence intensity illustrates：In the KCl concentration constant intervals of 0-2M
Fluorescence intensity knots modification very little.This advantage in practical application to being very helpful.
5th, fluorescent carbon point CNDs is used as logic gate on a molecular scale.
Input signal：Contain dopamine or Al3+, it is worth for 1, is otherwise 0 output signal：Fluorescence recovers, and is worth for 1, fluorescence
Quenching value is 0 (excitation wavelength 423nm)
Only carbon dots when, dopamine=0Al3+=0 has fluorescence=1
In carbon dots dopamine system, dopamine=1Al3+=0 fluorescent quenching=0
Carbon dots and Al3+Dopamine=0Al in system3+=1 has fluorescence=1
Carbon dots dopamine, Al3+Dopamine=1Al in system3+=1 fluorescence recovers=1
Exercisable logic gate can be built according to this principle.
Claims (1)
1. a kind of carry out dopamine and Al using carbon quantum dot3+Detection method, it is characterised in that：Include the following steps：
1. with citric acid and 4,7,10- tri- oxygen -1,13- tridecyl amines are as raw material, the fluorescent carbon obtained by one step hydro thermal method
Point CNDs；
2. utilize detections of the fluorescent carbon point CNDs to dopamine-sensitive, selectivity and concentration：
A, dopamine is added gradually in fluorescent carbon point solution according to concentration from 0 μM -200 μM, the change of fluorescence intensity
And linear relationship of the concentration between the dopamine between 20 μM -80 μM and fluorescent quenching efficiency F0/F -1, the results showed that with
The addition of dopamine, fluorescence intensity gradually decreases, and illustrates sensitiveness of this carbon dots for dopamine very well and with very
0.0078 μM of low test limit；
B, influence tests of the fluorescent carbon point CNDs to fluorescent quenching is carried out：The carbon dots for showing to use in the present invention is tested to dopamine
Selectivity is very well；
3. using fluorescent carbon point CNDs to Al3+The detection of sensitiveness, selectivity and concentration：
A, concentration is gradually added into the carbon dots solution of the dopamine containing 1mM from 0 μM -200 μM of Al3+It was observed that fluorescence intensity
It is significantly raised, CNDs- dopamine systems are designated to Al3+Sensitiveness it is fine；
B, by fluorescence intensity and Al3+Relation data between concentration, wherein Al3+Concentration c scope obtains between 4 μM -40 μM
To equation F0/F-1=-0.0058-0.0069c, wherein F0 is not contain Al3+When fluorescence intensity, F Al3+When concentration is c
Fluorescence intensity, related coefficient 0.9928.Detection is limited to 0.0329 μM；
C, the carbon dots solution without dopamine is carried out to Al3+Sensitivity tests；
D, fluorescent carbon point is carried out to Al3+Selectivity test, the results show Al3+Fluorescence intensity is influenced maximum；
4. the test influenced into the concentration of trip temperature, pH value, standing time and carbon dots on fluorescent carbon point fluorescence intensity；
5. structure one kind is with dopamine and Al3+Based on logic gate:
Input signal：Contain dopamine or Al3+, it is worth for 1, is otherwise 0 output signal：Fluorescence recovers, and is worth for 1, fluorescent quenching
It is worth for 0 (excitation wavelength 423nm)
Only carbon dots when, the Al of dopamine=03+=0 has fluorescence=1
In carbon dots dopamine system, the Al of dopamine=13+=0 fluorescent quenching=0
Carbon dots and Al3+The Al of dopamine in system=03+=1 has fluorescence=1
Carbon dots dopamine, Al3+The Al of dopamine in system=13+=1 fluorescence recovers=1.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610959134.5A CN108020531A (en) | 2016-11-03 | 2016-11-03 | It is a kind of to carry out dopamine and Al using fluorescent carbon point3+Detection method |
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| CN201610959134.5A CN108020531A (en) | 2016-11-03 | 2016-11-03 | It is a kind of to carry out dopamine and Al using fluorescent carbon point3+Detection method |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106855514A (en) * | 2016-11-15 | 2017-06-16 | 天津工业大学 | One kind is applied to detect dopamine and Al3+, the carbon point of cell imaging and gate operation |
| CN109913200A (en) * | 2019-03-28 | 2019-06-21 | 汤新红 | A kind of nano material and preparation method thereof with magnetism and fluorescent dual function |
| CN111208101A (en) * | 2020-01-15 | 2020-05-29 | 湖南农业大学 | Method for conveniently detecting aluminum ions based on carbon quantum dots synthesized by flavonoid glycoside and derivatives thereof |
| CN112920190A (en) * | 2021-01-27 | 2021-06-08 | 重庆师范大学 | Reaction product of dopamine and resorcinol, preparation method and application thereof |
-
2016
- 2016-11-03 CN CN201610959134.5A patent/CN108020531A/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| FANYONG YAN ET. AL.: "Carbon nanodots prepared for dopamine and Al3+ sensing, cellular imaging and logic gate operation", 《MATERIAL SCIENCE AND ENGINEERING C》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106855514A (en) * | 2016-11-15 | 2017-06-16 | 天津工业大学 | One kind is applied to detect dopamine and Al3+, the carbon point of cell imaging and gate operation |
| CN109913200A (en) * | 2019-03-28 | 2019-06-21 | 汤新红 | A kind of nano material and preparation method thereof with magnetism and fluorescent dual function |
| CN111208101A (en) * | 2020-01-15 | 2020-05-29 | 湖南农业大学 | Method for conveniently detecting aluminum ions based on carbon quantum dots synthesized by flavonoid glycoside and derivatives thereof |
| CN111208101B (en) * | 2020-01-15 | 2022-03-04 | 湖南农业大学 | Method for conveniently detecting aluminum ions based on carbon quantum dots synthesized by flavonoid glycoside and derivatives thereof |
| CN112920190A (en) * | 2021-01-27 | 2021-06-08 | 重庆师范大学 | Reaction product of dopamine and resorcinol, preparation method and application thereof |
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Application publication date: 20180511 |