CN108014416A - A kind of pre- aseptic infusion connector and preparation method thereof - Google Patents
A kind of pre- aseptic infusion connector and preparation method thereof Download PDFInfo
- Publication number
- CN108014416A CN108014416A CN201711476921.5A CN201711476921A CN108014416A CN 108014416 A CN108014416 A CN 108014416A CN 201711476921 A CN201711476921 A CN 201711476921A CN 108014416 A CN108014416 A CN 108014416A
- Authority
- CN
- China
- Prior art keywords
- linkage section
- piston
- horizontal segment
- infusion connector
- aseptic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/10—Tube connectors; Tube couplings
- A61M39/16—Tube connectors; Tube couplings having provision for disinfection or sterilisation
- A61M39/162—Tube connectors; Tube couplings having provision for disinfection or sterilisation with antiseptic agent incorporated within the connector
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/02—General characteristics of the apparatus characterised by a particular materials
- A61M2205/0205—Materials having antiseptic or antimicrobial properties, e.g. silver compounds, rubber with sterilising agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2207/00—Methods of manufacture, assembly or production
Abstract
The present invention relates to infusion connector technical field, more particularly to a kind of pre- aseptic infusion connector and preparation method thereof.The pre- aseptic infusion connector includes upper shell, the lower housing shell being connected with the upper shell and the piston containing anti-infectives, wherein the piston is arranged in the inner cavity of the upper shell.Pre- aseptic infusion connector of the present invention and preparation method thereof, can effectively prevent the generation of conduit related blood stream infections, simple in structure, and easily operated, self-closed effect is good, sterilize easy to be thorough.
Description
Technical field
The present invention relates to infusion connector technical field, more particularly to a kind of pre- aseptic infusion connector and its preparation side
Method.
Background technology
During clinical test, when patient needs long-term infusion, it will usually which non small cellCatheter is infused, existing
Needleless connection infusion techn has commonly to be connected with positive pressure.For common transfusion connector usually using 1~5 day, positive pressure connection was usually used
It is not easy to clean, it is necessary to often replace since bacterium easily invades within 15 days, cause patient's Yi Fasheng conduit related blood flow senses
Dye, and indwelling time is short, increases patient economy burden and the workload of medical staff.
The content of the invention
(1) technical problems to be solved
The object of the present invention is to provide a kind of pre- aseptic infusion connector and preparation method thereof, existing infusion connector is solved
Existing bacterium easily invades, not easy to clean, and indwelling time is short, it is necessary to often replace, and easily leads to the problem of patient infects.
(2) technical solution
In order to solve the above technical problem, the present invention provides a kind of pre- aseptic infusion connector, including upper shell, with
The lower housing shell that the upper shell is connected and the piston containing anti-infectives, wherein, the piston is arranged on the upper casing
In the inner cavity of body.
Further, the piston is equipped with yi word pattern, the cross or conical cut penetrated through from top to bottom, described anti-infective
Medicine is arranged in the notch.
Further, the upper shell is made of interconnected the first linkage section and the second linkage section, and described first connects
The outside for connecing section is equipped with external screw thread, and the internal diameter of first linkage section is less than the internal diameter of second linkage section.
Further, the lower housing shell is made of the 3rd linkage section being connected with each other and the 4th linkage section, and the described 3rd connects
Connect the outside that section is arranged on the 4th linkage section；3rd linkage section and second linkage section are tightly connected, and described the
The upper end of four linkage sections is arranged in the inner cavity of second linkage section, the lower end of the 4th linkage section stretch out be arranged at it is described
The outside of 3rd linkage section.
Specifically, the upper end of the 3rd linkage section is equipped with connection boss, and the 3rd linkage section is convex by the connection
Platform welds with second linkage section, be bonded or be connected together；The lower end inner wall of 3rd linkage section is equipped with internal thread.
Further, the piston is I-shaped structure, and the piston is by the first horizontal segment, first vertical that is connected with each other
Section and the second horizontal segment composition, wherein the length of the first horizontal segment is less than the length of second horizontal segment；Described second
Horizontal segment is arranged in the inner cavity of second linkage section, the upper end of the 4th linkage section and the lower end of second horizontal segment
It is in sealing contact；The first horizontal segment stretches out the inner cavity of first linkage section, and the upper surface of the first horizontal segment is higher than
1~5mm of upper surface of first linkage section.
Further, the piston is inverted T font structures, and the piston is by the second vertical section being connected with each other and
Three horizontal segments form, wherein the 3rd horizontal segment is arranged in the inner cavity of second linkage section, the 4th linkage section
Upper end and the lower end of the 3rd horizontal segment are in sealing contact；Second vertical section is arranged on the inner cavity of first linkage section
In, and the upper surface of the 3rd horizontal segment is concordant with the upper surface of first linkage section.
Specifically, the piston is made of medical silica-gel or medical elastic polyurethane material.
Present invention also offers a kind of pre- aseptic infusion connector preparation method, include the following steps：
Two kinds of solvents of methanol and ethyl acetate, be placed in a glass container by S1, uses blender to stir 5~20 points
Clock, anti-infectives are added in the glass container and continue to stir, until fully dissolving is prepared as anti-infective liquid；
S2, heat the anti-infective liquid using constent temperature heater, the anti-infective fluid temperature is reached 30~60
Spend and remain stable；
Piston carrier, be completely soaked 10~60 minutes in the anti-infective liquid after heating and take out by S3, clear with purified water
The anti-infective liquid in addition to notch on the piston carrier is washed, then dries the piston carrier, is obtained containing anti-infective
The piston of medicine；
Piston containing anti-infectives, be installed in upper shell by S4, then the upper shell pacified with lower housing shell
Dress, makes the upper shell be connected to form sealing infusion channel with the lower housing shell, obtains pre- aseptic infusion connector.
Further, the anti-infectives are the mixture of minocycline hydrochloride, rifampin or both, wherein every milliliter
Contain 0.5~100mg of minocycline hydrochloride, 0.25~100mg of rifampin in the anti-infective liquid.
Further, the methanol uses the methanol of concentration >=99%, and the ethyl acetate uses the second of concentration >=98%
Acetoacetic ester, wherein the content of methanol described in the anti-infectious agent liquid is 12~40%, the content of the ethyl acetate for 60~
88%.
(3) beneficial effect
The above-mentioned technical proposal of the present invention has the following advantages that：
Pre- aseptic infusion connector provided by the invention and preparation method thereof, upper shell is connected with lower housing shell to be formed
Infusion channel is sealed, by setting the piston containing anti-infectives in upper shell, effectively prevents conduit related blood flow sense
The generation of dye, simple in structure, easily operated, self-closed effect is good, sterilizes easy to be thorough.
Pre- aseptic infusion connector provided by the invention and preparation method thereof, before infusion, the work containing anti-infectives
Plug is completely in air-tight state, effectively prevents from inhibiting bacteria and foreign matter intrusion double insurance；During infusion, by pre- connected device tool from work
End insertion, piston and pre- connected device tool tight fit are filled in, effectively pre- liquid-leakage preventing leakage blood；At the end of infusion, pre- connected device tool is extracted
Piston can close completely automatically, while be connected in upper shell with lower housing shell in the sealing infusion channel to be formed and automatically generate just
Pressure, effectively avoids due to extracting leakage caused by pre- connected device tool, leakage blood phenomenon, infection prevention effect is more preferable.
Brief description of the drawings
Fig. 1 is the structure diagram of the pre- aseptic infusion connector of the embodiment of the present invention one；
Fig. 2 is the first sectional view of the pre- aseptic infusion connector of the embodiment of the present invention one；
Fig. 3 is second of sectional view of the pre- aseptic infusion connector of the embodiment of the present invention one；
Fig. 4 is the upper shell structure diagram of the pre- aseptic infusion connector of the embodiment of the present invention one；
Fig. 5 is the lower housing shell structure diagram of the pre- aseptic infusion connector of the embodiment of the present invention one；
Fig. 6 is the first piston structure figure of the pre- aseptic infusion connector of the embodiment of the present invention one；
Fig. 7 is second of piston structure figure of the pre- aseptic infusion connector of the embodiment of the present invention one.
In figure：1：Upper shell；101：First linkage section；102：Second linkage section；2：Lower housing shell；201：3rd linkage section；
202：4th linkage section；203：Boss；3：Piston；301：First horizontal segment；302：First vertical section；303：Second horizontal segment；
304：Second vertical section；305：3rd horizontal segment；306：Notch.
Embodiment
To make the purpose, technical scheme and advantage of the embodiment of the present invention clearer, below in conjunction with the embodiment of the present invention
In attached drawing, the technical solution in the embodiment of the present invention is clearly and completely described, it is clear that described embodiment is
The part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, ordinary skill people
Member's all other embodiments obtained on the premise of creative work is not made, belong to the scope of protection of the invention.
Embodiment one
As shown in figs. 1-7, the embodiment of the present invention provides a kind of pre- aseptic infusion connector, including upper shell 1 and upper casing
The lower housing shell 2 that body 1 is connected and the piston 3 containing anti-infectives, wherein, piston 3 is arranged in the inner cavity of upper shell 1.
Furthermore, it is understood that anti-infectives are the mixture of minocycline hydrochloride, rifampin or both.
Wherein, minocycline hydrochloride be a kind of wide spectrum, efficient, quick-acting, long-acting semi-synthetic antibacterial tetracycline class antibiotic,
Disturb albumen to synthesize by the retardance combined to the proper upper acceptor site of Aminoacyl transfer RNA and mRNA ribose, therefore play
Bacteriostasis, has good bacteriostatic activity and longer half-life period.
Wherein, rifampin is a kind of common broad-spectrum antibiotic medicine, can firmly be tied with the b for the RNA polymerases for relying on DNA
Close, inhibit bacteria the synthesis of RNA, prevent the enzyme to be connected with DNA, so as to block rna transcription process, make the synthesis of DNA and albumen
Stop.
If minocycline hydrochloride and sharp good fortune are used in mixed way, reduce the drug resistance of independent medication, enhance infusion
The antibacterial bacterium spectrum of connector, so that effectively prevention infection, is reduced to incidence at least.
Specifically, piston 3 is made of medical silica-gel or medical elastic polyurethane material, is equipped with piston 3 from upper
To the notch 306 of lower perforation, notch 306 is yi word pattern, cross or taper, and anti-infectives are arranged in notch 306, pass through
Anti-infectives are set in notch 306, then can be infused after pre- connected device tool is inserted at notch 306, it is easy to operate, automatically
Sealing effect is good, can effectively prevent the generation of conduit related blood stream infections, sterilizes easy to be thorough.
Specifically, upper shell 1 is made of interconnected the first linkage section 101 and the second linkage section 102, the first connection
The internal diameter of section 101 is less than the internal diameter of the second linkage section 102.
Wherein, the outside of the first linkage section 101 is equipped with external screw thread, for connecting external lug.
Specifically, lower housing shell 2 is made of the 3rd linkage section 201 being connected with each other and the 4th linkage section 202, the 3rd connection
Section 201 is arranged on the outside of the 4th linkage section 202.
Wherein, the 3rd linkage section 201 is tightly connected with the second linkage section 102, so that between upper shell 1 and lower housing shell 2
Form the infusion channel being fully sealed.
Specifically, the upper end of the 3rd linkage section 201 is equipped with connection boss 203, and the 3rd linkage section 201 is by connecting boss
203 welded with the second linkage section 102, is be bonded or be connected together.
Wherein, the upper end of the 4th linkage section 202 is arranged in the inner cavity of the second linkage section 102, under the 4th linkage section 202
The outside for being arranged at the 3rd linkage section 201 is stretched out at end.
Wherein, internal thread is equipped with the lower end inner wall of the 3rd linkage section 201, for connecting external lug.
Specifically, piston 3 has following two structures：
The first, piston 3 be I-shaped structure, piston 3 is by the first horizontal segment 301, the first vertical section 302 that are connected with each other
Formed with the second horizontal segment 303, wherein the length of first horizontal segment 301 is less than the length of the second horizontal segment 303.Second horizontal segment
303 are arranged in the inner cavity of the second linkage section 102, and the upper end of the 4th linkage section 202 and the lower end sealing of the second horizontal segment 303 connect
Touch.First horizontal segment 301 can be stretched out to the inner cavity of the first linkage section 101, and make the upper surface of first horizontal segment 301 higher than the
1~5mm of upper surface of one linkage section 101, if Fig. 6 is the first piston structure figure, if Fig. 2 is after being mounted with the first piston
Infusion connector structure chart.
Secondth, piston 3 is inverted T font structures, and piston 3 is by the second vertical section 304 being connected with each other and the 3rd water
Flat section 305 forms, wherein the 3rd horizontal segment 305 is arranged in the inner cavity of the second linkage section 102, the upper end of the 4th linkage section 202
It is in sealing contact with the lower end of the 3rd horizontal segment 305.Second vertical section 304 is arranged in the inner cavity of the first linkage section 101, can be incited somebody to action
The upper surface of 3rd horizontal segment 305 is concordant with the upper surface of the first linkage section 101 to be set, if Fig. 7 is second of piston structure figure,
If Fig. 3 is to be mounted with the infusion connector structure chart after second of piston.
Before infusion, piston 3 is completely in air-tight state, is combined by the closed in itself of piston 3 with anti-infectives, double
Weight is securely effectively prevented from inhibiting bacteria and invaded with foreign matter.During infusion, pre- connected device tool is inserted at the notch 306 of piston 3, it is living
Plug 3 and pre- connected device tool tight fit, effectively pre- liquid-leakage preventing leakage blood.At the end of infusion, piston 3 with the extraction of pre- connected device tool and from
Dynamic closure, while be connected in upper shell 1 with lower housing shell 2 in the sealing infusion channel to be formed and automatically generate positive pressure completely, effectively
Avoid due to extracting leakage caused by pre- connected device tool, leakage blood phenomenon.
In Clinical practice, anti-infectives can be sustained around piston 3 and to prevent infusion connector infected, so as to keep away
Exempt to cause patient to infect since infusion connector infects.
Embodiment two
The embodiment of the present invention provides a kind of pre- aseptic infusion connector preparation method, is used to prepare described in embodiment one
Pre- aseptic infusion connector, this method specifically comprise the following steps：
S1, by two kinds of solvents of ethyl acetate of the methanol of concentration >=99% and concentration >=98% be placed in a glass container
In, stirred 5~20 minutes using blender, anti-infectives are added in glass container and continue to stir, until fully dissolving is made
Standby is anti-infective liquid.
S2, heat anti-infective liquid using constent temperature heater, anti-infective fluid temperature is reached 30~60 degree and maintains
Stablize.
Piston carrier, be completely soaked 10~60 minutes in the anti-infective liquid after heating and take out by S3, clear with purified water
Remaining anti-infective liquid in addition to notch is washed on piston carrier, piston carrier is then placed in fume hood and is dried within 1~2 day, is obtained
Obtain the piston containing anti-infectives.
Piston containing anti-infectives, be installed in upper shell by S4, then upper shell and lower housing shell installed, and makes
Upper shell is connected to form sealing infusion channel with lower housing shell, obtains pre- aseptic infusion connector.
In the present embodiment, anti-infectives are minocycline hydrochloride, contain hydrochloric acid minot in every milliliter of anti-infective liquid
0.5~100mg of ring element.
In the present embodiment, the content of methanol is 40% in anti-infective liquid, and the content of ethyl acetate is 60%.
Embodiment three
The embodiment of the present invention provides a kind of pre- aseptic infusion connector preparation method, is used to prepare described in embodiment one
Pre- aseptic infusion connector, this method specifically comprise the following steps：
S1, by two kinds of solvents of ethyl acetate of the methanol of concentration >=99% and concentration >=98% be placed in a glass container
In, stirred 5~20 minutes using blender, anti-infectives are added in glass container and continue to stir, until fully dissolving is made
Standby is anti-infective liquid.
S2, heat anti-infective liquid using constent temperature heater, anti-infective fluid temperature is reached 30~60 degree and maintains
Stablize.
Piston carrier, be completely soaked 10~60 minutes in the anti-infective liquid after heating and take out by S3, clear with purified water
Remaining anti-infective liquid in addition to notch is washed on piston carrier, then piston carrier will be placed in 30~60 degree of baking ovens and dried in the air
It is dry, obtain the piston containing anti-infectives.
Piston containing anti-infectives, be installed in upper shell by S4, then upper shell and lower housing shell installed, and makes
Upper shell is connected to form sealing infusion channel with lower housing shell, obtains pre- aseptic infusion connector.
In the present embodiment, anti-infectives are rifampin, in every milliliter of anti-infective liquid containing rifampin 0.25~
100mg。
In the present embodiment, the content of methanol is 12% in anti-infective liquid, and the content of ethyl acetate is 88%.
Example IV
The embodiment of the present invention provides a kind of pre- aseptic infusion connector preparation method, is used to prepare described in embodiment one
Pre- aseptic infusion connector, this method specifically comprise the following steps：
S1, by two kinds of solvents of ethyl acetate of the methanol of concentration >=99% and concentration >=98% be placed in a glass container
In, stirred 5~20 minutes using blender, anti-infectives are added in glass container and continue to stir, until fully dissolving is made
Standby is anti-infective liquid.
S2, heat anti-infective liquid using constent temperature heater, anti-infective fluid temperature is reached 30~60 degree and maintains
Stablize.
Piston carrier, be completely soaked 10~60 minutes in the anti-infective liquid after heating and take out by S3, clear with purified water
Remaining anti-infective liquid in addition to notch is washed on piston carrier, then piston carrier will be placed in 30~60 degree of baking ovens and dried in the air
It is dry, obtain the piston containing anti-infectives.
Piston containing anti-infectives, be installed in upper shell by S4, then upper shell and lower housing shell installed, and makes
Upper shell is connected to form sealing infusion channel with lower housing shell, obtains pre- aseptic infusion connector.
In the present embodiment, anti-infectives are minocycline hydrochloride and the mixture of rifampin, wherein every milliliter of anti-sense
Contain 0.5~100mg of minocycline hydrochloride, 0.25~100mg of rifampin in dye liquid.
In the present embodiment, the content of methanol is 15% in anti-infective liquid, and the content of ethyl acetate is 85%.
In conclusion pre- aseptic infusion connector described in the embodiment of the present invention and preparation method thereof, by by upper casing
Body is connected to form sealing infusion channel with lower housing shell, and the piston containing anti-infectives, Neng Gouyou are set in upper shell
The generation of effect prevention conduit related blood stream infections, simple in structure, easily operated, self-closed effect is good, sterilizes easy to be thorough.
Finally it should be noted that：The above embodiments are merely illustrative of the technical solutions of the present invention, rather than its limitations；Although
The present invention is described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that：It still may be used
To modify to the technical solution described in foregoing embodiments, or equivalent substitution is carried out to which part technical characteristic；
And these modification or replace, do not make appropriate technical solution essence depart from various embodiments of the present invention technical solution spirit and
Scope.
Claims (10)
- A kind of 1. pre- aseptic infusion connector, it is characterised in that the lower casing being connected including upper shell, with the upper shell Body and the piston containing anti-infectives, wherein, the piston is arranged in the inner cavity of the upper shell.
- 2. pre- aseptic infusion connector according to claim 1, it is characterised in that the piston is equipped with and passes through from top to bottom Logical yi word pattern, cross or conical cut, the anti-infectives are arranged in the notch.
- 3. pre- aseptic infusion connector according to claim 1, it is characterised in that the upper shell by be interconnected First linkage section and the second linkage section composition, the outside of first linkage section are equipped with external screw thread, first linkage section it is interior Footpath is less than the internal diameter of second linkage section；The lower housing shell is made of the 3rd linkage section being connected with each other and the 4th linkage section, and the 3rd linkage section is arranged on described The outside of 4th linkage section；3rd linkage section is tightly connected with second linkage section, the upper end of the 4th linkage section It is arranged in the inner cavity of second linkage section, the lower end of the 4th linkage section, which is stretched out, is arranged at the outer of the 3rd linkage section Portion.
- 4. pre- aseptic infusion connector according to claim 3, it is characterised in that the upper end of the 3rd linkage section is set There is a connection boss, the 3rd linkage section welded by the connection boss with second linkage section, be bonded or be connected together； The lower end inner wall of 3rd linkage section is equipped with internal thread.
- 5. pre- aseptic infusion connector according to claim 4, it is characterised in that the piston is I-shaped structure, The piston is made of the first horizontal segment, the first vertical section and the second horizontal segment being connected with each other, wherein the first horizontal segment Length be less than second horizontal segment length；Second horizontal segment is arranged in the inner cavity of second linkage section, institute Upper end and the lower end of second horizontal segment for stating the 4th linkage section are in sealing contact；The first horizontal segment is stretched out described first and is connected The inner cavity of section is connect, and the upper surface of the first horizontal segment is higher than 1~5mm of upper surface of first linkage section.
- 6. pre- aseptic infusion connector according to claim 4, it is characterised in that the piston is inverted T fonts Structure, the piston are made of the second vertical section being connected with each other and the 3rd horizontal segment, wherein the 3rd horizontal segment is arranged on In the inner cavity of second linkage section, the upper end and the lower end of the 3rd horizontal segment of the 4th linkage section are in sealing contact；Institute State the second vertical section to be arranged in the inner cavity of first linkage section, and the upper surface of the 3rd horizontal segment connects with described first The upper surface for connecing section is concordant.
- 7. pre- aseptic infusion connector according to claim 1, it is characterised in that the piston using medical silica-gel or Medical elastic polyurethane material is made.
- It is 8. a kind of such as the pre- aseptic infusion connector preparation method of claim 1-7 any one of them, it is characterised in that including Following steps：Two kinds of solvents of methanol and ethyl acetate, be placed in a glass container by S1, uses blender to stir 5~20 minutes, will Anti-infectives, which are added in the glass container, to be continued to stir, until fully dissolving is prepared as anti-infective liquid；S2, heat the anti-infective liquid using constent temperature heater, the anti-infective fluid temperature is reached 30~60 degree simultaneously Maintain to stablize；Piston carrier, be completely soaked 10~60 minutes in the anti-infective liquid after heating and take out by S3, and institute is cleaned with purified water The anti-infective liquid in addition to notch on piston carrier is stated, then dries the piston carrier, acquisition contains anti-infectives Piston；Piston containing anti-infectives, be installed in upper shell by S4, then the upper shell installed with lower housing shell, makes The upper shell is connected to form sealing infusion channel with the lower housing shell, obtains pre- aseptic infusion connector.
- 9. pre- aseptic infusion connector preparation method according to claim 8, it is characterised in that the anti-infectives For the mixture of minocycline hydrochloride, rifampin or both, wherein containing hydrochloric acid minot ring in every milliliter of anti-infective liquid Element 0.5~100mg, 0.25~100mg of rifampin.
- 10. pre- aseptic infusion connector preparation method according to claim 8, it is characterised in that the methanol uses The methanol of concentration >=99%, the ethyl acetate uses the ethyl acetate of concentration >=98%, wherein institute in the anti-infectious agent liquid The content for stating methanol is 12~40%, and the content of the ethyl acetate is 60~88%.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201711476921.5A CN108014416A (en) | 2017-12-29 | 2017-12-29 | A kind of pre- aseptic infusion connector and preparation method thereof |
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| CN201711476921.5A CN108014416A (en) | 2017-12-29 | 2017-12-29 | A kind of pre- aseptic infusion connector and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115217277A (en) * | 2022-08-19 | 2022-10-21 | 上海兴筑建筑设计有限公司 | Glass curtain wall structure with self-cleaning function |
| CN115260730A (en) * | 2022-07-29 | 2022-11-01 | 珠海金导医疗科技有限公司 | Antibacterial infusion joint and preparation method thereof |
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| CN104203194A (en) * | 2012-02-02 | 2014-12-10 | 碧迪股份有限公司 | Adaptor for coupling with a medical container |
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| US20160089530A1 (en) * | 2014-09-29 | 2016-03-31 | Becton, Dickinson And Company | Medical Device Cap for Drug Transfer Assembly |
| CN204181950U (en) * | 2014-10-23 | 2015-03-04 | 北京天地和协科技有限公司 | A kind of Needleless seal formula infusion connector |
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